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22 results on '"Irwin, Beth"'

1. The use of parent‐completed questionnaires to investigate developmental outcomes in large populations of children exposed to antiseizure medications in pregnancy

Author

Bluett‐Duncan, Matthew, primary, Bullen, Philip, additional, Campbell, Ellen, additional, Clayton‐Smith, Jill, additional, Craig, John, additional, García‐Fiñana, Marta, additional, Hughes, David M., additional, Ingham, Amy, additional, Irwin, Beth, additional, Jackson, Cerian, additional, Kelly, Teresa, additional, Morrow, James, additional, Rushton, Sarah, additional, Winterbottom, Janine, additional, Wood, Amanda G., additional, Yates, Laura M., additional, and Bromley, Rebecca L., additional

Published
2024
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2. Neurodevelopment of babies born to mothers with epilepsy: A prospective observational cohort study

Author

Bromley, Rebecca, Bullen, Philip, Campbell, Ellen, Craig, John, Ingham, Amy, Irwin, Beth, Jackson, Cerain, Kelly, Teresa, Morrow, James, Rushton, Sarah, García-Fiñana, Marta, Hughes, David M., Winterbottom, Janine, Wood, Amanda, Yates, Laura M., Clayton-Smith, Jill, the NaME Study Group, Bromley, Rebecca, Bullen, Philip, Campbell, Ellen, Craig, John, Ingham, Amy, Irwin, Beth, Jackson, Cerain, Kelly, Teresa, Morrow, James, Rushton, Sarah, García-Fiñana, Marta, Hughes, David M., Winterbottom, Janine, Wood, Amanda, Yates, Laura M., Clayton-Smith, Jill, and the NaME Study Group

Abstract

Objective: Despite widespread monotherapy use of lamotrigine or levetiracetam during pregnancy, prospectively collected, blinded child development data are still limited. The NaME (Neurodevelopment of Babies Born to Mothers With Epilepsy) Study prospectively recruited a new cohort of women with epilepsy and their offspring for longitudinal follow-up. Methods: Pregnant women of <21 weeks gestation (n = 401) were recruited from 21 hospitals in the UK. Data collection occurred during pregnancy (recruitment, trimester 3) and at 12 and 24 months of age. The primary outcome was blinded assessment of infant cognitive, language, and motor development on the Bayley Scales of Infant and Toddler Development (3rd edition) at 24 months of age with supplementary parent reporting on the Vinelands Adaptive Behavior Scales (2nd edition). Results: There were 394 live births, with 277 children (70%) completing the Bayley assessment at 24 months. There was no evidence of an association of prenatal exposure to monotherapy lamotrigine (−.74, SE = 2.9, 95% confidence interval [CI] = −6.5 to 5.0, p =.80) or levetiracetam (−1.57, SE = 3.1, 95% CI = −4.6 to 7.7, p =.62) with poorer infant cognition, following adjustment for other maternal and child factors in comparison to nonexposed children. Similar results were observed for language and motor scores. There was no evidence of an association between increasing doses of either lamotrigine or levetiracetam. Nor was there evidence that higher dose folic acid supplementation (≥5 mg/day) or convulsive seizure exposure was associated with child development scores. Continued infant exposure to antiseizure medications through breast milk was not associated with poorer outcomes, but the number of women breastfeeding beyond 3 months was low. Significance: These data are reassuring for infant development following in utero exposure to monotherapy lamotrigine or levetiracetam, but child development is dynamic, and future follow-up is required to rule o

Published
2023

3. Neurodevelopment of babies born to mothers with epilepsy: A prospective observational cohort study.

Author

Bromley, Rebecca L., Bullen, Philip, Campbell, Ellen, Craig, John, Ingham, Amy, Irwin, Beth, Jackson, Cerain, Kelly, Teresa, Morrow, James, Rushton, Sarah, García‐Fiñana, Marta, Hughes, David M., Winterbottom, Janine, Wood, Amanda, Yates, Laura M., Clayton‐Smith, Jill, Bromley, Rebecca, Jackson, Cerian, Bullen, Phil, and Riley, Lauren

Subjects
TODDLERS development, MOTHERS, COHORT analysis, INFANT development, EPILEPSY
Abstract

Objective: Despite widespread monotherapy use of lamotrigine or levetiracetam during pregnancy, prospectively collected, blinded child development data are still limited. The NaME (Neurodevelopment of Babies Born to Mothers With Epilepsy) Study prospectively recruited a new cohort of women with epilepsy and their offspring for longitudinal follow‐up. Methods: Pregnant women of <21 weeks gestation (n = 401) were recruited from 21 hospitals in the UK. Data collection occurred during pregnancy (recruitment, trimester 3) and at 12 and 24 months of age. The primary outcome was blinded assessment of infant cognitive, language, and motor development on the Bayley Scales of Infant and Toddler Development (3rd edition) at 24 months of age with supplementary parent reporting on the Vinelands Adaptive Behavior Scales (2nd edition). Results: There were 394 live births, with 277 children (70%) completing the Bayley assessment at 24 months. There was no evidence of an association of prenatal exposure to monotherapy lamotrigine (−.74, SE = 2.9, 95% confidence interval [CI] = −6.5 to 5.0, p =.80) or levetiracetam (−1.57, SE = 3.1, 95% CI = −4.6 to 7.7, p =.62) with poorer infant cognition, following adjustment for other maternal and child factors in comparison to nonexposed children. Similar results were observed for language and motor scores. There was no evidence of an association between increasing doses of either lamotrigine or levetiracetam. Nor was there evidence that higher dose folic acid supplementation (≥5 mg/day) or convulsive seizure exposure was associated with child development scores. Continued infant exposure to antiseizure medications through breast milk was not associated with poorer outcomes, but the number of women breastfeeding beyond 3 months was low. Significance: These data are reassuring for infant development following in utero exposure to monotherapy lamotrigine or levetiracetam, but child development is dynamic, and future follow‐up is required to rule out later emerging effects. [ABSTRACT FROM AUTHOR]

Published
2023
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9. U.K. Epilepsy and Pregnancy Group

Author

Russell, Aline J.C., Craig, John J., Morrison, Patrick, Irwin, Beth, Waddell, Ruth, Parsons, Linda, Robertson, Iain, Guthrie, Eleanor, and Morrow, Jim I.

Published
2004

10. Changing antiepilepsy drug-prescribing trends in women with epilepsy in the UK and Ireland and the impact on major congenital malformations

Author

Kinney, Michael O, primary, Morrow, James, additional, Patterson, Chris C, additional, Campbell, Ellen, additional, Russell, Aline, additional, Smithson, Henry W, additional, Parsons, Linda, additional, Morrison, Patrick J, additional, Bromley, Rebecca, additional, Liggan, Brenda, additional, Delanty, Norman, additional, Irwin, Beth, additional, Hunt, Stephen J, additional, and Craig, John J, additional

Published
2018
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12. Child development following in utero exposure:levetiracetam vs sodium valproate

Author

Shallcross, R, Bromley, R L, Irwin, B, Bonnett, L J, Morrow, J, Baker, G A, Fryer, Alan, Kneen, Rachel, Banka, Siddharth, Briggs, Maria, Clayton-Smith, Jill, Mawer, George, Baker, Gus, Bromley, Rebecca, Dixon, Pete, Gummery, Alison, Shallcross, Rebekah, Kerr, Loretta, Craig, John, Hunt, Stephen, Irwin, Beth, Morrison, Patrick, Morrow, James, Delanty, Norman, Liggan, Brenda, Russell, Aline, Smithson, Henry, Parsons, Linda, and Robertson, Iain

Subjects
Pediatrics, medicine.medical_specialty, Levetiracetam, Population, Clinical Neurology, Epilepsy, Child Development, Cognition, Pregnancy, Humans, Medicine, education, Maternal-Fetal Exchange, Retrospective Studies, Valproic Acid, education.field_of_study, business.industry, Infant, Articles, medicine.disease, Piracetam, Child development, Pregnancy Complications, El Niño, Maternal Exposure, In utero, Child, Preschool, Prenatal Exposure Delayed Effects, Anticonvulsants, Female, Neurology (clinical), business, medicine.drug
Abstract

Children born to women with epilepsy (WWE), exposed in utero to levetiracetam (LEV, n = 51), were assessed for early cognitive development and compared to children exposed to sodium valproate in utero (VPA, n = 44) and a group of children representative of the general population (n = 97).Children were recruited prospectively from 2 cohorts in the United Kingdom and assessed using the Griffiths Mental Development Scale (1996), aged24 months. Information regarding maternal demographics were collected and controlled for. This is an observational study with researchers not involved in the clinical management of the WWE.On overall developmental ability, children exposed to LEV obtained higher developmental scores when compared to children exposed to VPA (p0.001). When compared, children exposed to LEV did not differ from control children (p = 0.62) on overall development. Eight percent of children exposed to LEV in utero fell within the below average range (DQ score of84), compared with 40% of children exposed to VPA. After controlling for maternal epilepsy and demographic factors using linear regression analysis, exposure to LEV in utero was not associated with outcome (p = 0.67). Conversely, when compared with VPA exposure, LEV exposure was associated with higher scores for the overall developmental quotient (p0.001).Children exposed to LEV in utero are not at an increased risk of delayed early cognitive development under the age of 24 months. LEV may therefore be a preferable drug choice, where appropriate, for WWE prior to and of childbearing age.

Published
2011
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14. Malformation Risks Of Antiepileptic Drug Monotherapies In Pregnancy: An Update From The UK and Ireland Epilepsy and Pregnancy Registers (I8-2.005)

Author

Campbell, Ellen, primary, Kennedy, Fiona, additional, Russell, Aline, additional, Smithson, W, additional, Linda, Parsons, additional, Irwin, Beth, additional, Liggan, Brenda, additional, Delanty, Norman, additional, Morrison, Patrick, additional, Hunt, Stephen, additional, Craig, John, additional, and Morrow, Jim, additional

Published
2014
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16. Malformation Risks Of Antiepileptic Drug Monotherapies In Pregnancy: An Update From The UK and Ireland Epilepsy and Pregnancy Registers (S59.001)

Author

Campbell, Ellen, primary, Kennedy, Fiona, additional, Russell, Aline, additional, Smithson, W, additional, Linda, Parsons, additional, Irwin, Beth, additional, Liggan, Brenda, additional, Delanty, Norman, additional, Morrison, Patrick, additional, Hunt, Stephen, additional, Craig, John, additional, and Morrow, Jim, additional

Published
2014
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21. Levetiracetam in pregnancy.

Author

Mawhinney, Ellen, Craig, John, Morrow, Jim, Russell, Aline, Smithson, W. Henry, Parsons, Linda, Morrison, Patrick J., Liggan, Brenda, Irwin, Beth, Delanty, Norman, and Hunt, Stephen J.

Published
2013

22. Seizing control.

Author

Irwin B

Subjects
Epilepsy complications, Epilepsy psychology, Female, Humans, Midwifery, Pregnancy, Pregnancy Complications psychology, Epilepsy nursing, Pregnancy Complications nursing
Published
2010

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