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Introduction. Today, there is an increase in the risks of involving minors in various forms of deviant behaviour, among the varieties of which addictive behavioural models are particularly dangerous. In this regard, proactive preventive measures are becoming particularly relevant, among which one of the key areas is the timely identification of potential addicts, including among students of educational organisations.Aim. The aim of the study was to identify the actual socio-psychological characteristics of the personality of underage students who are prone to addictive behaviour.Methodology and research methods. The comparative-analytical method of working with scientific literature presented in eLIBRARY.RU, Scopus, Web of Science and Google Scholar databases was used as the main theoretical method. When organising the study, the authors relied on a number of methodological provisions: the structural method, when the research material is interpreted in accordance with the specific characteristics of the object of study; the method of comparisons, which consists in comparing individual results with each other. The main empirical method was the testing method. To obtain the results of the study, the authors employed a unified methodology of socio-psychological testing aimed at the identification of the risk of formation of addictive behaviour in minors. For mathematical and statistical data processing, the Statistics SPSS 19.0 package was applied: the Kolmogorov-Smirnov Dmax criterion (for boys and girls separately and jointly), the Mann-Whitney U test, regression analysis, analysis of averages, confidence and percentile intervals. Also, the factor analysis method was used – the principal component method, Varimax rotation. The stability of factors was calculated using the Lewandowski’s method. The study was conducted in different regions of Russia in 2019–2020. The sample consisted of 6,300 people.Results. Based on the analysis of scientific sources, the authors described the epidemiological picture of various forms of addictive behaviour of minors, the differences between male and female samples (young men demonstrate a greater desire for leadership, protest reactions, rivalry, and girls are more anxious, frustrated, focused on internal experiences), the interrelationships between the scales of the methodology and the poles of the selected factor structure from the point of view of asociality and prosociality of juvenile behaviour (desire for risk, social maladjustment, avoidance of conflict and others).Scientific novelty. The scientific novelty of the results is due to the receipt of relevant data on the specifics of the socio-psychological characteristics of modern adolescents and young men prone to addictive behaviour.Practical significance. The practical significance lies in the fact that the identified socio-psychological characteristics of the behaviour of a person prone to addictive behaviour can become the main planning work on the early detection of a tendency to addictive behaviour, organisation of preventive work with imperfect-year-olds, as well as for the organisation of psychological work with students at risk.

Introduction. The relevance of this study is determined, on the one hand, by the need for prevention and early identification of deviant behaviors among minors against the background of the growth of epidemiology and forms of addictive behaviors among other forms of risk behaviors of schoolchildren and students, on the other hand, by the lack of appropriate diagnostic tools that have been validated by the appropriate psychometric procedures. Currently, in the Russian Federation, a unified method of socio-psychological assessment of minors (hereinafter ‘UM-SPT’) is being massively implemented. It is aimed at identifying the latent and obvious risks within socio-psychological conditions that determine psychological readiness for addictive behaviors in adolescents and young people. The aim of this study was to conduct an empirical analysis of the psychometric indicators within "UM-SPT" (e.g. reliability, validity, discriminativeness) in order to reveal the limitations of the methodology and its application in the regions. Materials and Methods. The data were processed using parametric and nonparametric criteria for communication, differences, consistency (Pearson, Student, Kolmogorov-Smirnov, Mann-Whitney, Fisher, Cronbach, and Spearman). Various types of statistical data analysis (correlation, regression, variance, factor) were used. Statistical data processing was carried out both manually and using the Statistica software package. The research was conducted in different regions of the Russian Federation. The sample consisted of 5100 people. Results. The authors found that all three forms of the technique have high indicators of synchronicity, internal consistency, and stability of the results. On the other hand, the study revealed factors of result distortion associated with the age, gender and region of residence of the subjects. An analysis of descriptive statistics showed a fairly high percentage of monotonous and stereotyped responses. When comparing the results of factor analysis with the content of the basic components of an addictive personality (‘self-control of behavior’, ‘attitude to norms’, ‘focus’, ‘conflict’, ‘strategies for overcoming cultural pressure’, ‘emotional sphere’, ‘a conflict with the social environment’), ameaningful coincidence of the factor structure with the content of these components was found. A disproportionate ratio of risk and protection factors in all three forms of the technique introduces significant distortions in the diagnostic results. Conclusions. The authors revealed and described the limitations of the methodology and risk areas of its application in the regions. The main indicators of reliability, validity, discriminativeness were identified on representative samples. Recommendations for improving the inventory were proposed.

Today’s youth are characterized by the diversification and turnover of collective actors claiming their interests, rights, and needs. ‘Dispersed’ politicization of youth is also manifested in the extending range of socio-political activities, which at the moment may take place not only in the vertical structure of official state institutions, but also in the horizontal plane of autonomous ‘grassroots’ initiatives according to D.I.Y pattern (Do It Yourself), which raises the issue of describing and systematizing these phenomena. The objective of this paper is to compile the outcomes of 2019 studies aimed at creating and testing the tools to describe the current phenomena of institutional and self-organized politicization of youth, namely, to develop the concept of sociological and political strategy and to determine the range of such strategies in the youth milieu. The paper presents the concept of the sociological and political strategy, including a methodological framework, a model and typology of sociological and political strategies of the Russian youth, comprising 10 main types with the focus on the institutional and self-organized patterns of political activities along with the main risks identified. The research methods: the content analysis of statements on the Internet (on thematic resources and social networks), the analysis of essays by students and school pupils (n = 21) regarding the issue of self-determination with respect to politics, interviews comprising the elements of case studies (n = 10) conducted in 2019 as well as the analysis of interview findings for 2017—2018 (n = 17). The diagnostic method – ‘Determination of the youth political strategy type’ was appraised (n = 55). The Delphi approach and brainstorming with elements of technology foresight were used at the phase of developing recommendations to work with the young.

One of the major goals in cardiac regeneration research is to replace lost ventricular tissue with new cardiomyocytes. However, cardiomyocyte proliferation drops to low levels in neonatal hearts and is no longer efficient in compensating for the loss of functional myocardium in heart disease. We generated a human induced pluripotent stem cell (iPSC)-derived cardiomyocyte-specific cell cycle indicator system (TNNT2-FUCCI) to characterize regular and aberrant cardiomyocyte cycle dynamics. We visualized cell cycle progression in TNNT2-FUCCI and found G2 cycle arrest in endoreplicating cardiomyocytes. Moreover, we devised a live-cell compound screening platform to identify pro-proliferative drug candidates. We found that the alpha-adrenergic receptor agonist clonidine induced cardiomyocyte proliferation in vitro and increased cardiomyocyte cell cycle entry in neonatal mice. In conclusion, the TNNT2-FUCCI system is a valuable tool to characterize cardiomyocyte cell cycle dynamics and identify pro-proliferative candidates with regenerative potential in the mammalian heart.

One of the major goals in cardiac regeneration research is to replace lost ventricular tissue with new cardiomyocytes. However, cardiomyocyte proliferation drops to low levels in neonatal hearts and is no longer efficient in compensating for the loss of functional myocardium in heart disease. We generated a human induced pluripotent stem cell (iPSC)-derived cardiomyocyte-specific cell cycle indicator system (TNNT2-FUCCI) to characterize regular and aberrant cardiomyocyte cycle dynamics. We visualized cell cycle progression in TNNT2-FUCCI and found G2 cycle arrest in endoreplicating cardiomyocytes. Moreover, we devised a live-cell compound screening platform to identify pro-proliferative drug candidates. We found that the alpha-adrenergic receptor agonist clonidine induced cardiomyocyte proliferation

Physiological liver cell replacement is central to maintaining the organ's high metabolic activity, although its characteristics are difficult to study in humans. Using retrospective radiocarbon (C-14) birth dating of cells, we report that human hepatocytes show continuous and lifelong turnover, allowing the liver to remain a young organ (average age