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El cambio climático ha afectado de manera desproporcionada a los sectores más vulnerables, y la eficiencia energética en edificaciones emerge como clave para mitigar y adaptarse a estos efectos. En México, los climas cálidos secos predominan en el 53% del territorio, especialmente en el norte, y aunque existe normativa para la eficiencia energética en la edificación, ésta tiene un impacto limitado. El estudio evalúa los costos y beneficios de dicha normativa que considera viviendas comunes en distintos climas de un estado del norte de México donde se analizaron 180 modelos y se concluyó que cumplir con la normativa aumentaría el costo de la vivienda en 1.93%, reduciría el consumo eléctrico en 26% y disminuiría las emisiones de CO2e en 16.95%. Estos beneficios se obtuvieron sin cambiar los sistemas constructivos más utilizados y se priorizó sistemas de sombreado. Los resultados podrían orientar a políticas públicas más adecuadas a los contextos locales.

Abstract Background In body-mind relationship field, eating disorders (ED) are considered disabling disorders that can alter physical health status, inducing profound alterations in psychosocial, cognitive and emotional dimensions. These disorders, characterized by a strong comorbidity with other diseases, usually begin during childhood or adolescence, and include anorexia nervosa, bulimia nervosa and binge eating. Aim of this study was to investigate the associations between eating disorders perception and dimensions of health-related quality of life (HRQoL) and well-being perception (WBP) in school-dropout adolescents. Methods Data were collected in 450 adolescents (19 ± 2 years, male 308), and HRQoL, WBP, and ED were assessed by means a battery of standardized questionnaire. Results EDs are more pronounced in females than in males (p

Caring for a child with an acute/life threatening disease exposes parents to multiple stressors and challenges, resulting in a physical and psychological burden. Parents experience many health-related issues and worries that often remain underestimated. The aims of the study were: (a) to explore the associations between needs/disease-related issues and burden in parents of children with leukemia or Hodgkin’s disease; (b) to estimate predictors of parents’ burden using a stepwise linear regression analysis. Children (N = 33) followed an active therapy protocol (48.5%), or they were off therapy (51.5%). Forty-four parents completed surveys on caregiver burden levels and needs to cope with the child’s illness. Parental factors impacting burden (personal resources, loss of control, depression) and child’s quality of life (QoL) were also assessed. Among the needs, information about the illness/resources were the most urgently expressed by parents, followed by reassurance against fears for the child’s development and future well-being. Parents reported severe (27.3%) and moderate (22.7%) burden, with a higher percentage of caregivers with severe burden in the off-therapy phase (18.2%) than in the active-therapy phase (9.1%). The child’s decreased physical QoL and parent’s loss of control predicted higher levels of burden. The implications for supportive interventions aimed at responding to parental needs and preventing caregiver burden are discussed.

Cold storage of platelets has been suggested as an alternative approach to reduce the risk of bacterial contamination and to improve the cell quality as well as functionality compared to room temperature storage. However, cold-stored platelets (CSP) are rapidly cleared from the circulation. Among several possible mechanisms, apoptosis has been recently proposed to be responsible for the short half-life of refrigerated platelets. In the present study, we investigated the impact of apoptosis inhibition on the hemostatic functions and survival of CSP. We found that blocking the transduction of the apoptotic signal induced by glycoprotein Ib (GPIb)-α clustering or the activation of caspase 9 does not impair CSP functionality. In fact, the inhibition of GPIb-α clustering mediated-apoptotic signal by a RhoA inhibitor better conserved δ granule release, platelet aggregation, adhesion and the ability to form stable clots, compared to untreated CSP. In contrast, upregulation of the protein kinase A caused a drastic impairment of platelet functions and whole blood clot stability. More importantly, we observed a significant improvement of the half-life of CSP upon inhibition of the intracellular signal induced by GPIb-α clustering. In conclusion, our study provides novel insights on the in vitro hemostatic functions and half-life of CSP upon inhibition of the intracellular cold-induced apoptotic pathway. Our data suggest that the combination of cold storage and apoptosis inhibition might be a promising strategy to prolong the storage time without impairing hemostatic functions or survival of refrigerated platelets.

Background: Bullying is a hostile behavior repeated over a time period, affecting children and adolescents in different social settings, mainly small and stable ones like school, with negative effects on mental and physical health. In this study, we aimed to provide the degree of impairment of different variables related to health and well-being in bullying conditions, with attention to sex differences. Methods: Data were obtained from 5390 adolescents (mean age 13.08 ± 1.89; male 2729), and health-related quality of life (HRQoL) was assessed using the KIDSCREEN-52 questionnaire. Results: In all students, mood and emotion, self-perception, and parental relationships are the dimensions more compromised in bullying conditions, while lifestyle habit is the variable less involved. Bullied girls show a significant impairment of all HRQoL variables both with respect to the socially accepted counterpart and to the male population. Conclusions: Our study highlights the strict association between bullying and emotional and social dimensions, suggesting that enhancing them preventively could facilitate earlier detection of problems, thereby reducing health risks.

Several therapeutic agents can cause thrombocytopenia by either immune-mediated or non-immune-mediated mechanisms. Non-immune-mediated thrombocytopenia is due to direct toxicity of drug molecules to platelets or megakaryocytes. Immune-mediated thrombocytopenia, on the other hand, involves the formation of antibodies that react to platelet-specific glycoprotein complexes, as in classic drug-induced immune thrombocytopenia (DITP), or to platelet factor 4, as in heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombotic thrombocytopenia (VITT). Clinical signs include a rapid drop in platelet count, bleeding or thrombosis. Since the patient's condition can deteriorate rapidly, prompt diagnosis and management are critical. However, the necessary diagnostic tests are only available in specialized laboratories. Therefore, the most demanding step in treatment is to identify the agent responsible for thrombocytopenia, which often proves difficult because many patients are taking multiple medications and have comorbidities that can themselves also cause thrombocytopenia. While DITP is commonly associated with an increased risk of bleeding, HIT and VITT have a high mortality rate due to the high incidence of thromboembolic complications. A structured approach to drug-associated thrombocytopenia/thrombosis can lead to successful treatment and a lower mortality rate. In addition to describing the treatment of DITP, HIT, VITT, and vaccine-associated immune thrombocytopenia, this review also provides the pathophysiological and clinical information necessary for correct patient management.

BackgroundHealth and well-being promotions are key points of educational programs for adolescents within schools. There are several health education programs mainly based on lifestyle habit changes; however, social and emotional dimensions should be considered within these educational strategies. ObjectiveThis study aimed to (1) develop a new web-based school support system to assess and analyze individual, classroom, and scholastic institute data on lifestyle habits, social context, emotional status, and scholastic performance; (2) create a web tool for managing the well-being of adolescents through a dynamic and personalized interface that provides immediate feedback that allows the school to monitor progress; and (3) evaluate, in a pilot study, the feasibility of this web-based school support system in order to build health programs that are specific to the needs of the studied population. MethodsThe AVATAR (a new purpose for the promotion and evaluation of health and well-being among healthy teenagers) method consists of integrating the information coming from different questionnaires. In particular, to allow planning didactic and educational actions based on the results obtained, the AVATAR approach allows subdivision of the results of the different observed variables and the 4 components into the following 3 percentile categories: modify, improve, and maintain. The AVATAR web platform was designed to collect data on lifestyle, emotional status, and social context from junior high schools in terms of the fundamental aspects of adolescent daily life, with free use by the scholastic community (scholars, teachers, and parents). In this pilot/feasibility study, data from 331 students were acquired between 2018 and 2019 at the beginning of the scholastic year (pre) and at the end following the school-based program (post). ResultsPreliminary results showed that after school planning and specific program implementation, defined after AVATAR feedback, students reported better well-being perception characterized by higher perception in psychological well-being (P=.001), mood (P=.001), self-perception (P=.006), and autonomy (P=.001), and an increase in the perception of financial resources (P=.001), which helped in developing healthy lifestyle habits (P=.007). In the social context assessment, students reported stronger relationships with family (P=.02) and peers (P=.001), and a lower perception of bullying (P=.001). ConclusionsThe AVATAR web-based platform is a feasible and flexible tool for the health and well-being management of adolescents from epidemiological, preventive, and educational points of view. In particular, it can be used to (1) promote information campaigns aimed at modifying risk behaviors in the student population, (2) sensitize students and put them at the center of their growth path, (3) inform institutions about the health and well-being of the school population, (4) ensure health programs are acceptable and feasible to users before launching on a large scale, and (5) improve the relationship of users (school) and educational agencies with research groups.

Objective: During the last decades, advances in computing power, structured data, and algorithm development, developed a technology based on Artificial intelligence (AI) which is currently applied in medicine. Nowadays, the main use of AI in breast imaging is in decision support in mammography, where it facilitates human decision-making as opposed to replacing radiologists. In this paper, we analyze how AI is currently involved in radiological decision-making and how will change both interpretation efficacy and workflow efficiency in breast imaging. Mechanism: We performed a non-systematic review on Pubmed and Scopus and Web of Science electronic databases from January 2001 to January 2022, using the following keywords: artificial intelligence, machine and deep learning, breast imaging and mammography. Findings in Brief: Many retrospective studies showed that AI can match or even enhance performances of radiologists in mammography interpretation. However, to assess the real role of AI in clinical practice compelling evidence from accurate perspective studies in large cohorts is needed. Breast imaging must face with the exponential growth in imaging requests (and consequently higher costs) and a predicted reduced number of trained radiologists to read imaging and provide reports. To mitigate these urges, solution is being sought with increasing investments in the application of AI to improve the radiology workflow efficiency as well as patient outcomes. Conslusions: This paper show the background on the evolution and the application of AI in breast imaging in 2022, in addition to exploring advantages and limitations of this innovative technology, as well as ethical and legal issues that have been identified so far.

The present paper focuses on the analysis of large data sets from public transport networks, more specifically, on how to predict urban bus passenger demand. A series of steps are proposed to ease the understanding of passenger demand. First, given the large number of stops in the bus network, these are divided into clusters and then different models are fitted for a representative of each of the clusters. The aim is to compare and combine the predictions associated with traditional methods, such as exponential smoothing or ARIMA, with machine learning methods, such as support vector machines or artificial neural networks. Moreover, support vector machine predictions are improved by incorporating explanatory variables with temporal structure and moving averages. Finally, through cointegration techniques, the results obtained for the representative of each group are extrapolated to the rest of the series within the same cluster. A case study in the city of Salamanca (Spain) is presented to illustrate the problem.

(1) Background: here is a growing need for integrated and multidimensional approaches to health, especially in a particular category of populations, school-dropout (SD) adolescents, who are traditionally more prone to risky behavior. This study aimed to describe the association between possible risk factors (substance use, eating disorders, social addiction) and well-being perception through the application of a personalized well-being index (PWBI) in SD youths. (2) Methods: Data were collected in 450 school-dropout adolescents (19 ± 2 years, male 308); the health-related quality of life (HRQoL) and risk behaviors were assessed by means of a battery of standardized questions. (3) Results: The results revealed an altered perception of well-being in association with eating disorders (p < 0.001), the use of psychotropic drugs (p < 0.001), and the amount of their consumption (p < 0.05). In particular, there was a decrease in emotional state (p < 0.001) and PWBI (p < 0.001) in the presence of eating disorders, and an impairment in all PWBI components, emotional states (p < 0.001), lifestyle habits (p < 0.05), and social contexts (p < 0.001) when taking psychotropic drugs. (4) Conclusions: risk or unhealthy behaviors significantly worsen individual well-being. This study highlights the change of paradigm from a disease-oriented model to an educationally strength-based model when monitoring psychosocial well-being in order to define preventive and health promotion strategies in a vulnerable category of the population.

In recent years, a growing number of large, densely populated cities have emerged, which need urban traffic planning and therefore knowledge of mobility patterns. Knowledge of space-time distribution of passengers in cities is necessary for effective urban traffic planning and restructuring, especially in large cities. In this paper, the inbound ridership in the Barcelona metro is modelled into a three-way tensor so that each element contains the number of passenger in the ith station at the jth time on the kth day. Tucker3 decomposition is used to discover spatial clusters, temporal patterns, and the relationships between them. The results indicate that travel patterns differ between weekdays and weekends; in addition, rush and off-peak hours of each day have been identified, and a classification of stations has been obtained.

El presente artículo ahonda en las relaciones mujer-arte entre los siglos XIX y XX en España, etapas de transición hacia una participación femenina como sujeto creador inédita por su temática y significación. Se trata de mostrar la evolución que se registra en el panorama artístico femenino desde la condescendencia decimonónica que permitía un acercamiento de las mujeres a la pintura como elemento de distracción, hasta su conquista, ya en las primeras décadas del siglo XX, por parte de un nuevo prototipo de mujer que desafió la estructura patriarcal a través de transgresiones estéticas y sociales sin precedentes. Para ilustrar esta realidad se ha escogido el ejemplo paradigmático de la artista zamorana Delhy Tejero, reflejo de la vanguardia española en apariencia, implicación y trayectoria profesional.

El artículo que aquí se presenta contiene reflexiones pedagógicas en torno a experiencias de integración que se suscitan al interior de la carrera de Arquitectura de la Universidad Abierta Interamericana —UAI—, sede Rosario. Dos líneas de trabajo interesa resaltar en términos pedagógicos: proyectos de integración centrados en un pensamiento acerca de los lenguajes de la arquitectura y sus modos de expresión y transmisión, por un lado, y, por el otro, propuestas de integración curricular caracterizadas por producir experiencias pedagógicas que ocasionen rupturas en los ritmos habituales del aula. Se presentarán para ello registros de observación de clase y documentos internos institucionales. Consideramos que estas reflexiones sobre la experiencia permitirán alcanzar hipótesis acerca de la transmisión propia de la época que nos toca vivir.

Immune thrombocytopenia is a common bleeding disease caused by autoantibody-mediated accelerated platelet clearance and impaired thrombopoiesis. Accumulating evidence suggests that desialylation affects platelet life span in immune thrombocytopenia. Herein, we report on novel effector functions of autoantibodies from immune thrombocytopenic patients which might interfere with the clinical picture of the disease. Data from our study show that a subgroup of autoantibodies is able to induce cleave of sialic acid residues from the surface of human platelets and megakaryocytes. Moreover, autoantibody-mediated desialylation interferes with the interaction between cells and extracellular matrix proteins leading to impaired platelet adhesion and megakaryocyte differentiation. Using a combination of ex vivo model of thrombopoiesis, a humanized animal model, and a clinical cohort study, we demonstrate that cleavage of sialic acid induces significant impairment in production, survival as well as function of human platelets. These data may indicate that prevention of desialylation should be investigated in the future in clinical studies as a potential therapeutic approach to treat bleeding in immune thrombocytopenia.

Platelet autoantibody-induced platelet clearance represents a major pathomechanism in immune thrombocytopenia (ITP). There is growing evidence for clinical differences between anti-glycoprotein IIb/IIIa and anti-glycoprotein Ib/IX mediated ITP. Glycoprotein V is a well characterized target antigen in Varicella-associated and drug-induced thrombocytopenia. We conducted a systematic study assessing the prevalence and functional capacity of autoantibodies against glycoprotein V. A total of 1140 patients were included. In one-third of patients, platelet-bound autoantibodies against glycoproteins Ib/IX, IIb/IIIa, or V were detected in a monoclonal antibody immobilization of platelet antigen assay; platelet-bound autoantiglycoprotein V was present in the majority of samples (222 out of 343, 64.7%). Investigation of patient sera revealed the presence of free autoantibodies against glycoprotein V in 13.5% of these patients by an indirect monoclonal antibody immobilization of platelet antigen assay, but in 39.6% by surface plasmon resonance technology. These antibodies showed significantly lower avidity (association/dissociation ratio 0.32±0.13 vs. 0.73±0.14; P

An accelerated life test of a product or material consists of the observation of its failure time when it is subjected to conditions that stress the usual ones. The purpose is to obtain the parameters of the distribution of the time-to-failure for usual conditions through the observed failure times. A widely used method to provoke an early failure in a mechanism is to modify the temperature at which it is used. In this paper, the statistically optimal plan for Accelerated Failure Time (AFT) models, when the accelerated failure process is described making use of Arrhenius or Eyring equations, was calculated. The result was a design that had only two stress levels, as is common in other AFT models and that is not always practical. A new compromise plan was presented as an alternative to the widely used “4:2:1 plan”. The three-point mixture design proposed specified a support point in the interval that was optimal for the estimation of the parameters in AFT models, rather than simply the middle point. It was studied in comparison to different commonly used designs, and it proved to have a higher D-efficiency than the others.

Platelet transfusion has become essential therapy in modern medicine. Although the clinical advantage of platelet transfusion has been well established, adverse reactions upon transfusion, especially transmission of bacterial infection, still represent a major challenge. While bacterial contamination is favored by the storage of platelets at room temperature, cold storage may represent a solution for this important clinical issue. In this study, we aimed to clarify whether plasma has protective or detrimental effects on cold-stored platelets. We investigated the impact of different residual plasma contents in apheresis-derived platelet concentrates, stored at 4°C or room temperature, on platelet function and survival. We found that platelets stored at 4°C have higher expression of apoptosis marker compared to platelets stored at room temperature, leading to accelerated clearance from the circulation in a humanized animal model. While cold-induced apoptosis was independent of the residual plasma concentration, cold storage was associated with better adhesive properties and higher response to activators. Interestingly, delta (δ) granule-related functions, such as ADP-mediated aggregation and CD63 release, were better preserved at 4°C, especially in 100% plasma. An extended study to assess cold-stored platelet concentrates produced under standard care Good Manufacturing Practice conditions showed that platelet function, metabolism and integrity were better compared to those stored at room temperature. Taken together, our results show that residual plasma concentration does not have a cardinal impact on the cold storage lesions of apheresis-derived platelet concentrates and indicate that the current generation of additive solutions represent suitable substitutes for plasma to store platelets at 4°C.

Mesenchymal stem cells (MSCs) are currently exploited as gene delivery systems for transient in situ expression of cancer therapeutics. As an alternative to the prevailing viral expression, we here describe a murine MSC line stably expressing a therapeutic protein for up to 42 passages, yet fully maintaining MSC features. Because of superior antitumoral activity of hexavalent TNF-related apoptosis-inducing ligand (TRAIL) formats and the advantage of a tumor-targeted action, we choose expression of a dimeric EGFR-specific diabody single-chain TRAIL (Db-scTRAIL) as a model. The bioactivity of Db-scTRAIL produced from an isolated clone (MSC.TRAIL) was revealed from cell death induction in Colo205 cells treated with either culture supernatants from or cocultured with MSC.TRAIL. In vivo, therapeutic activity of MSC.TRAIL was shown upon peritumoral injection in a Colo205 xenograft tumor model. Best antitumor activity in vitro and in vivo was observed upon combined treatment of MSC.TRAIL with bortezomib. Importantly, in vivo combination treatment did not cause apparent hepatotoxicity, weight loss, or behavioral changes. The development of well characterized stocks of stable drug-producing human MSC lines has the potential to establish standardized protocols of cell-based therapy broadly applicable in cancer treatment.

Este trabajo presenta las concepciones docentes acerca de su formación permanente. Se identificaron distintos puntos de análisis relacionados con la antigüedad en la profesión, intereses metodológicos, intereses de actualización de conocimientos, intereses de incorporación de nuevos saberes y, por último, el lugar que ocupa la formación en la subjetividad docente. En los inicios de la docencia, la formación permanente funciona y se concibe como un modo de mantenerse activos mientras se insertan en el mercado laboral. En cambio, para los docentes que ya tienen una trayectoria, esta se concibe como una fuga del trabajo, un recurso que en ocasiones le otorga sentido al trabajo, asumiendo de este modo un lugar subjetivo importante en el quehacer docente. Pero, cualquiera que sea la motivación, la adquisición de nuevos saberes es la razón más antigua que los docentes asumen para formarse.Este trabalho apresenta as concepções docentes sobre sua formação permanente. Identificaram-se diferentes pontos de análise relacionados com a antiguidade na profissão, interesses metodológicos, interesses de atualização de conhecimentos, interesses de incorporação de novos saberes e, por último, o lugar que a formação ocupa na subjetividade docente. No início da docência, a formação permanente funciona e se concebe como um modo de se manterem ativos enquanto se inserem no mercado de trabalho. Em compensação, para os docentes que já têm uma trajetória, esta se concebe como uma fuga do trabalho, um recurso que em ocasiões outorga sentido ao trabalho e assume, desse modo, um lugar subjetivo importante no fazer docente. Contudo, qualquer que seja a motivação, a aquisição de novos saberes é a razão mais antiga que os docentes assumem para se formar.This study delves into what teachers think about their own continuing education. Different points of analysis are identified with respect to seniority in the profession, methodological interests, interest in updating know-how, interest in incorporating new knowledge and, finally, the place training occupies in the teacher's subjective thinking. At the onset of teaching, continuing education works and is conceived as a way to stay active while entering the job market. In contrast, for teachers who already have a history in the profession, it is viewed as an escape from work or a recourse that occasionally gives meaning to work, thus assuming an important subjective place in the teacher's vocation. Yet, regardless of the motivation, the acquisition of new knowledge is the most enduring reason teachers draw on to further their training.

Este artículo se enmarca en un proceso de investigación que se viene llevando a cabo desde el año 2006. En el mismo abordamos los nuevos requerimientos de trabajo y formación docentes que plantean las políticas públicas educativas de los 90 hasta nuestros días, desde las concepciones docentes. En esta presentación nos interesa plantear un recorrido por las diversas leyes, documentos y resoluciones que dieron materialidad a las reformas educativas argentinas de las últimas décadas con respecto a la formación docente. Por tanto, el objetivo de este trabajo es enmarcar los procesos de transformación de la formación docente argentina en los procesos históricos, políticos y sociales tanto a nivel regional como mundial, a través de sus expresiones documentales.

This essay presents an overview of different perspectives of the risk-taking construct in the development of speaking skills in the second language classroom. Its main purpose is to examine the role of risk taking in the acquisition of a foreign or second language and the improvement of oral proficiency. The first section introduces the concept of risk taking from markedly different perspectives of several authors. The second section focuses on the particular traits that characterize risk takers in the language learning scenario. The third section explains the distinctive variables, namely, situational, social and individual, which are responsible for differences in risk-taking levels. The last section compares and contrasts the high and low use of risk-taking behaviors which leads to a final discussion and reflection on some pedagogical issues concerning risk taking in the second language classroom.

The aim of this work was to (i) determine the chemical composition of the essential oils of three spices widely cultivated in Spain from organic growth: Foeniculum vulgare, Petroselium crispum, and Lavandula officinalis; (ii) determine the total phenolic content; (iii) determine the antioxidant activity of the essentials oils by means of three different antioxidant tests and (iv) determine the effectiveness of these essentials oils on the inhibition of Listeria innocua CECT 910 and Pseudomonas fluorescens CECT 844. There is a great variability in the chemical composition of the essential oils. Parsley had the highest phenolic content. Overall, parsley presented the best antioxidant profile, given its highest % of inhibition of DPPH radical (64.28%) and FRAP (0.93 mmol/L Trolox), but had a pro-oxidative behavior by TBARS. Lavender essential oil showed the highest antibacterial activity against L. innocua (>13 mm of inhibition at 20–40 μL oil in the discs), followed by parsley with an inhibition zone of 10 mm (when more than 5 μL oil in the discs), and fennel 10 mm (when more than 40 μL oil in the discs). P. fluorescens was not inhibited by the tested essential oils.

El presente estudio analiza la utilidad de la repetición y los códigos de colores para ayudar a un grupo de estudiantes avanzados de inglés a pronunciar el sufijo morfológico -(e)d en las formas verbales regulares del pasado y el participio pasado. Para el estudio, se eligieron tres profesores de ingeniería de la Universidad de Costa Rica. Los resultados indican que la identificación y la pronunciación de los alomorfos /t/ y /d/ presentan mayor dificultad que el alomorfo /Id/. La repetición fue efectiva para identificar las realizaciones de -(e)d; no obstante, ésta no promovió la autonomía de los estudiantes en la producción de los sonidos. El código de colores ayudó a los estudiantes a auto corregirse. Asimismo, el número de errores disminuyó cuando se utilizó dicha técnica. A pesar de las ventajas del código de colores, se concluye que es necesario practicar y reciclar ambas técnicas en la clase para promover el aprendizaje de una segunda lengua.

Recently, the term of digital university has been a buzzword or trend in different contexts in Spanish-speaking countries. However, there is no available clear definition of the concept that helps us specify its implementation further. Therefore, this study was aimed at analyzing the different existing conceptions of digital university in Ibero-America, via a systematic literature review and the analysis of the semantic field through a network analysis. This enabled us to identify what was understood by being a digital university from the perspective of different Ibero-American universities. Spanish keywords derived from the thesaurus -including “digital university”- were used in the search through diverse catalogs and databases, and documents of different kinds were found between 2007 and 2017. The literature review was based on the abstracts of the documents and we considered the creation of categories with diverse topics that represent how Ibero-America understands the digital university and with which restrictions has to deal with. The discussion incorporates the integration of those categories and topics into the digital university models that were previously identified. As a conclusion, a summary on the concept of digital university is presented and we point towards some remarks so that the conception is made a reality in its practice.