Search

Cotton fibre maturity is the measure of cotton’s secondary cell wall thickness. Both immature and over-mature fibres are undesirable in textile industry due to the various problems caused during different manufacturing processes. The determination of cotton fibre maturity is of vital importance and various methods and techniques have been devised to measure or calculate it. Artificial neural networks have the power to model the complex relationships between the input and output variables. Therefore, a model was developed for the prediction of cotton fibre maturity using the fibre characteristics. The results of predictive modelling showed that mean absolute error of 0.0491 was observed between the actual and predicted values, which show a high degree of accuracy for neural network modelling. Moreover, the importance of input variables was also defined.

Alzheimer's disease (AD) is a progressive neurological disorder characterized by memory loss, cognitive decline, and behavioral changes. Immunotherapy aims to harness the immune system to target the underlying pathology of AD and has shown promise as a disease-modifying treatment for AD. By focusing on the underlying disease pathogenesis and encouraging the removal of abnormal protein aggregates in the brain, immunotherapy shows promise as a potential treatment for AD. The development of immunotherapy for AD began with early attempts to use antibodies to target beta-amyloid. The amyloid hypothesis which suggests that the accumulation of beta-amyloid in the brain triggers the pathological cascade that leads to AD has been a driving force behind the development of immunotherapy for AD. However, recent clinical trials of monoclonal antibodies targeting amyloid-β have shown mixed results, highlighting the need for further research into alternative immunotherapy approaches. Additionally, the safety and efficacy of immunotherapy for AD remain an area of active investigation. Some immunotherapeutic approaches have shown promise, while others have been associated with significant side effects, including inflammation of the brain. Sleep has a significant impact on various physiological processes, including the immune system, and has been linked to the pathogenesis of AD. Thus, improving sleep quality and duration may benefit the immune system and potentially enhance the effectiveness of immunotherapeutic approaches for AD. In this review, we discussed the promises of immunotherapy as a disease-modifying treatment for AD as well as possible methods to improve the efficacy and safety of immunotherapy to achieve better therapeutic outcomes. [ABSTRACT FROM AUTHOR]

Cervical cancer (CC) is themost common cancer in women and poses a serious threat to health. Despite familiaritywith the factors affecting its etiology, initiation, progression, treatment strategies, and even resistance to therapy, it is considered a significant problem for women. However, several factors have greatly affected the previous aspects of CC progression and treatment in recent decades. miRNAs are short noncoding RNA sequences that regulate gene expression by inhibiting translation of the targetmRNA. miRNAs play a crucial role in CCpathogenesis by promoting cancer stem cell (CSC) proliferation, postponing apoptosis, continuing the cell cycle, and promoting invasion, angiogenesis, and metastasis. Similarly, miRNAs influence important CCrelated molecular pathways, such as the PI3K/AKT/mTOR signaling pathway, Wnt/ß-catenin system, JAK/STAT signaling pathway, and MAPK signaling pathway. Moreover, miRNAs affect the response of CC patients to chemotherapy and radiotherapy. Consequently, this review aims to provide an acquainted summary of onco miRNAs and tumor suppressor (TS) miRNAs and their potential role in CC pathogenesis and therapy responses by focusing on the molecular pathways that drive them. [ABSTRACT FROM AUTHOR]

The seminar on "Ethics in Islam" was held in Faridabad, Haryana, on July 30-31 1988, sponsored by the Institute of Objective Studies, New Delhi and the Department of Philosophy at Aligarh Muslim University, Aligarh, India. Mr. Muqimuddin, the seminar organizer, opened the proceedings by remarking at the outset that the seminar's theme was of prime importance in the context of the present world. Justifying any aspect of Islamic Ethics is both tricky and difficult. According to him, ethics has developed in the West in the form of philosophical theories but classical philosophers did not give much attention to the theoretical aspects of Islamic Ethics and virtually no effort has been made toward the documentation of ethics in Islam. The keynote address, delivered by Dr. Mohammed Abdul Haq Ansari entitled "Islamic Ethics: Concept and Prospect," (presently a professor at Imam Muhammad Islamic University, Riyadh, Saudi Arabia), reviewed different streams of writing in the spheres of Islamic philosophy, Sufism, theology, jurisprudence, politics, and economy, and highlighted the contribution each has made to the subject. He asserted that in view of the material available in these writings, Islamic scholars of our time can develop a veritable chronicle of Islamic Ethics in a period shorter than the Islamic econoll}ists have taken to develop Islamic Economics. According to Prof. Ansari, there is a wellformulated system of morality in the Qur'an, but there is no such theorization in the field of ethics. He pointed out that there are several ethical problems which need our attention while proceeding towards theorization of Islamic Ethics, e.g., determinism, freedom of will, distinction between good and evil, etc. The keynote address was followed by a lively discussion. Prof. Fazlur Rahman Ginnori was of the opinion that Islam has provided a complete code of morality obliviating the need for theorizing about Islamic Ethics. Other participants were of the opinion that in order to convince the world of the feasibility of Islamic Ethics, especially because of its identification with most aspects of science, there is a need for an ethical theory of Islam. Dr. Sanaullah Mir of Aligarh Muslim University, Aligarh, India, read a paper on "Philosophical Justification of the Islamic Ethical Standard: the Ontological and Deontological Standards." While discussing the nature of ...

Liver cancer is the second leading cause of cancer-related death worldwide. However, treatment options, including surgical resection, transplantation, and molecular drug therapies, are of limited effectiveness. Recent studies have demonstrated that suppressing ferroptosis might be a pivotal signal for liver cancer initiation, thus providing a new way to combat liver cancer. Ferroptosis is a distinct form of controlled cell death that differs from conventional cell death routes like apoptosis, necrosis, and pyroptosis. It results from intracellular iron overload, which raises iron-dependent reactive oxygen species. This, in turn, leads to the accumulation of lipid peroxides that further result in oxidative damage to cell membranes, disrupt normal functioning, and ultimately speed up the ferroptosis phenomenon. Ferroptosis regulation is intricately linked to cellular physiological processes, encompassing iron metabolism, lipid metabolism, and the equilibrium between oxygen-free radical reactions and lipid peroxidation. This review intends to summarize the natural compounds targeting ferroptosis in liver cancer to offer new therapeutic ideas for liver cancer. Furthermore, it serves as the foundation for identifying and applying chemical medicines and natural chemicals that target ferroptosis to treat liver cancer efficiently. [ABSTRACT FROM AUTHOR]

Currently, statins, the β-hydroxy-β-methyl-glutaryl-CoA reductase (HMG-R) inhibitors, are widely used to lower cholesterol, nevertheless, they have several side effects. Consequently, the present study is designed to unravel the cardioprotective role of selected natural monoterpenoids (carvacrol and geraniol) via in-vitro targeting and molecular informatics study of HMG-R. Computational molecular informatics study revealed that carvacrol and geraniol efficiently occupies the catalytic site of HMG-R with the binding affinity (ΔG) of −4.60, and −1.99 Kcal/mol, respectively, and molecular mechanical-generalized Born surface area (MM-GBSA) free binding energy was depicted as −17.05 and −29.48 Kcal/mol, respectively. Further, molecular dynamics simulation was carried out for 100 ns. Carvacrol and geraniol potentially and competitively inhibit the in-vitro HMG-R activity with an IC50 value of 78.23 ± 2.21 μM, and 72.91 ± 2.92 μM, respectively. Thus, both carvacrol and geraniol exhibited significant anti-hypercholesterolemic activity while the molecular simulation studies depicted that the GR complex showed better stability than the carvacrol complex. [ABSTRACT FROM AUTHOR]

The most practical method of drug delivery is oral administration because it has a high rate of patient compliance. However, there are significant obstacles to effective oral medication delivery, including low drug enzymatic/metabolic stability and poor water solubility. Especially in the development of drug formulations for the treatment of obesity and hypertension. This research article aims to formulate solid lipid nanoparticles (SLN) of Fucoxanthin and Ramipril by the emulsification and ultrasonication methods. The nanoparticles size, polydispersity index, and the zeta potential, among other parameters, were computed. In addition, FT-IR analysis of compatibility tests between the SLNs and the loaded drug and in vitro drug release experiments were carried out. Lipid-based nano preparations have drawn plenty of interest as efficient vehicles to increase the oral bioavailability of these kinds of medications. We observed that lipid nanoparticles, have enhanced the oral bioavailability of poorly water-soluble drugs used for obesity and hypertension. Provided the above information, formulated SLNs should be further investigated using cutting-edge scientific methodologies to improve its bioavailability. [ABSTRACT FROM AUTHOR]