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16 results on '"Ippolito, Elio"'

1. The IL-8-CXCR1/2 axis contributes to diabetic kidney disease

Author

Loretelli, Cristian, Rocchio, Francesca, D'Addio, Francesca, Ben Nasr, Moufida, Castillo-Leon, Eduardo, Dellepiane, Sergio, Vergani, Andrea, Abdelsalam, Ahmed, Assi, Emma, Maestroni, Anna, Usuelli, Vera, Bassi, Roberto, Pastore, Ida, Yang, Jun, El Essawy, Basset, Elased, Khalid M., Fadini, Gian Paolo, Ippolito, Elio, Seelam, Andy Joe, Pezzolesi, Marcus, Corradi, Domenico, Zuccotti, Gian Vincenzo, Gallieni, Maurizio, Allegretti, Marcello, Niewczas, Monika Anna, and Fiorina, Paolo

Published
2021
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2. Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection

Author

Montefusco, Laura, Ben Nasr, Moufida, D’Addio, Francesca, Loretelli, Cristian, Rossi, Antonio, Pastore, Ida, Daniele, Giuseppe, Abdelsalam, Ahmed, Maestroni, Anna, Dell’Acqua, Marco, Ippolito, Elio, Assi, Emma, Usuelli, Vera, Seelam, Andy Joe, Fiorina, Roberta Maria, Chebat, Enrica, Morpurgo, Paola, Lunati, Maria Elena, Bolla, Andrea Mario, Finzi, Giovanna, Abdi, Reza, Bonventre, Joseph V., Rusconi, Stefano, Riva, Agostino, Corradi, Domenico, Santus, Pierachille, Nebuloni, Manuela, Folli, Franco, Zuccotti, Gian Vincenzo, Galli, Massimo, and Fiorina, Paolo

Published
2021
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3. Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children

Author

Vecchione, Andrea, Di Fonte, Roberta, Gerosa, Jolanda, Jofra, Tatiana, Cicalese, Maria Pia, Napoleone, Vincenzo, Ippolito, Elio, Galvani, Giuseppe, Ragogna, Francesca, Stabilini, Angela, Bianconi, Eleonora, Grogan, Pauline, Bonura, Clara, Bonfanti, Riccardo, Frontino, Giulio, Nano, Rita, Melzi, Raffaela, De Pellegrin, Maurizio, Laurenzi, Andrea, Meschi, Franco, Barera, Graziano, Rigamonti, Andrea, Indirli, Rita, Bosi, Emanuele, Piemonti, Lorenzo, Aiuti, Alessandro, Battaglia, Manuela, and Fousteri, Georgia

Published
2020
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4. Embryonic stem cell extracts improve wound healing in diabetic mice

Author

Loretelli, Cristian, Ben Nasr, Moufida, Giatsidis, Giorgio, Bassi, Roberto, Lancerotto, Luca, D’Addio, Francesca, Valderrama-Vasquez, Alessandro, Scherer, Saja Sandra, Salvatore, Luca, Madaghiele, Marta, Abdelsalam, Ahmed, Ippolito, Elio, Assi, Emma, Usuelli, Vera, El Essawy, Basset, Sannino, Alessandro, Pietramaggiori, Giorgio, Zuccotti, Gian Vincenzo, Orgill, Dennis Paul, and Fiorina, Paolo

Published
2020
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5. Indirect and Direct Effects of SARS-CoV-2 on Human Pancreatic Islets

Author

Nasr, Moufida Ben, primary, D’Addio, Francesca, primary, Montefusco, Laura, primary, Usuelli, Vera, primary, Loretelli, Cristian, primary, Rossi, Antonio, primary, Pastore, Ida, primary, Abdelsalam, Ahmed, primary, Maestroni, Anna, primary, Dell’Acqua, Marco, primary, Ippolito, Elio, primary, Assi, Emma, primary, Seelam, Andy Joe, primary, Fiorina, Roberta Maria, primary, Chebat, Enrica, primary, Morpurgo, Paola, primary, Lunati, Maria Elena, primary, Bolla, Andrea Mario, primary, Abdi, Reza, primary, Bonventre, Joseph V., primary, Rusconi, Stefano, primary, Riva, Agostino, primary, Corradi, Domenico, primary, Santus, Pierachille, primary, Clark, Pamela, primary, Nebuloni, Manuela, primary, Baldi, Gabriella, primary, Finzi, Giovanna, primary, Folli, Franco, primary, Zuccotti, Gian Vincenzo, primary, Galli, Massimo, primary, Herold, Kevan C., primary, and Fiorina, Paolo, primary

Published
2022
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6. Indirect and Direct Effects of SARS-CoV-2 on Human Pancreatic Islets

Author

Ben Nasr, Moufida, primary, D’Addio, Francesca, additional, Montefusco, Laura, additional, Usuelli, Vera, additional, Loretelli, Cristian, additional, Rossi, Antonio, additional, Pastore, Ida, additional, Abdelsalam, Ahmed, additional, Maestroni, Anna, additional, Dell’Acqua, Marco, additional, Ippolito, Elio, additional, Assi, Emma, additional, Seelam, Andy Joe, additional, Fiorina, Roberta Maria, additional, Chebat, Enrica, additional, Morpurgo, Paola, additional, Lunati, Maria Elena, additional, Bolla, Andrea Mario, additional, Abdi, Reza, additional, Bonventre, Joseph V., additional, Rusconi, Stefano, additional, Riva, Agostino, additional, Corradi, Domenico, additional, Santus, Pierachille, additional, Clark, Pamela, additional, Nebuloni, Manuela, additional, Baldi, Gabriella, additional, Finzi, Giovanna, additional, Folli, Franco, additional, Zuccotti, Gian Vincenzo, additional, Galli, Massimo, additional, Herold, Kevan C., additional, and Fiorina, Paolo, additional

Published
2022
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7. PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response

Author

Loretelli, Cristian, primary, Abdelsalam, Ahmed, additional, D’Addio, Francesca, additional, Ben Nasr, Moufida, additional, Assi, Emma, additional, Usuelli, Vera, additional, Maestroni, Anna, additional, Seelam, Andy Joe, additional, Ippolito, Elio, additional, Di Maggio, Stefania, additional, Loreggian, Lara, additional, Radovanovic, Dejan, additional, Vanetti, Claudia, additional, Yang, Jun, additional, El Essawy, Basset, additional, Rossi, Antonio, additional, Pastore, Ida, additional, Montefusco, Laura, additional, Lunati, Maria Elena, additional, Bolla, Andrea M., additional, Biasin, Mara, additional, Antinori, Spinello, additional, Santus, Pierachille, additional, Riva, Agostino, additional, Zuccotti, Gian Vincenzo, additional, Galli, Massimo, additional, Rusconi, Stefano, additional, and Fiorina, Paolo, additional

Published
2021
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8. Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes

Author

Vecchione, Andrea, primary, Jofra, Tatiana, primary, Gerosa, Jolanda, primary, Shankwitz, Kimberly, primary, Fonte, Roberta Di, primary, Galvani, Giuseppe, primary, Ippolito, Elio, primary, Cicalese, Maria Pia, primary, Schultz, Andrew R., primary, Seay, Howie R., primary, Favellato, Mariagrazia, primary, Milardi, Giulia, primary, Stabilini, Angela, primary, Ragogna, Francesca, primary, Grogan, Pauline, primary, Bianconi, Eleonora, primary, Laurenzi, Andrea, primary, Caretto, Amelia, primary, Nano, Rita, primary, Melzi, Raffaela, primary, Danzl, Nichole, primary, Bosi, Emanuele, primary, Piemonti, Lorenzo, primary, Aiuti, Alessandro, primary, Brusko, Todd, primary, Petrovas, Constantinos, primary, Battaglia, Manuela, primary, and Fousteri, Georgia, primary

Published
2021
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9. Anti-diabetic drugs and weight loss in patients with type 2 diabetes

Author

Lazzaroni, Elisa, primary, Ben Nasr, Moufida, additional, Loretelli, Cristian, additional, Pastore, Ida, additional, Plebani, Laura, additional, Lunati, Maria Elena, additional, Vallone, Luciana, additional, Bolla, Andrea Mario, additional, Rossi, Antonio, additional, Montefusco, Laura, additional, Ippolito, Elio, additional, Berra, Cesare, additional, D’Addio, Francesca, additional, Zuccotti, Gian Vincenzo, additional, and Fiorina, Paolo, additional

Published
2021
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10. Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study

Author

Solerte, Sebastiano Bruno, primary, D’Addio, Francesca, additional, Trevisan, Roberto, additional, Lovati, Elisabetta, additional, Rossi, Antonio, additional, Pastore, Ida, additional, Dell’Acqua, Marco, additional, Ippolito, Elio, additional, Scaranna, Cristiana, additional, Bellante, Rosalia, additional, Galliani, Silvia, additional, Dodesini, Alessandro Roberto, additional, Lepore, Giuseppe, additional, Geni, Francesca, additional, Fiorina, Roberta Maria, additional, Catena, Emanuele, additional, Corsico, Angelo, additional, Colombo, Riccardo, additional, Mirani, Marco, additional, De Riva, Carlo, additional, Oleandri, Salvatore Endrio, additional, Abdi, Reza, additional, Bonventre, Joseph V., additional, Rusconi, Stefano, additional, Folli, Franco, additional, Di Sabatino, Antonio, additional, Zuccotti, Gianvincenzo, additional, Galli, Massimo, additional, and Fiorina, Paolo, additional

Published
2020
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11. Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes.

Author

Vecchione, Andrea, Jofra, Tatiana, Gerosa, Jolanda, Shankwitz, Kimberly, Di Fonte, Roberta, Galvani, Giuseppe, Ippolito, Elio, Cicalese, Maria Pia, Schultz, Andrew R., Seay, Howie R., Favellato, Mariagrazia, Milardi, Giulia, Stabilini, Angela, Ragogna, Francesca, Grogan, Pauline, Bianconi, Eleonora, Laurenzi, Andrea, Caretto, Amelia, Nano, Rita, and Melzi, Raffaela

Subjects
REGULATORY T cells, TYPE 1 diabetes, LYMPH nodes, SPLEEN, LABORATORY mice, AUTOIMMUNE diseases, PANCREAS, RESEARCH, CELL culture, ANIMAL experimentation, RESEARCH methodology, CASE-control method, EVALUATION research, COMPARATIVE studies, RESEARCH funding, LYMPHOCYTE count, MICE
Abstract

In the attempt to understand the origin of autoantibody (AAb) production in patients with and at risk for type 1 diabetes (T1D), multiple studies have analyzed and reported alterations in T follicular helper (Tfh) cells in presymptomatic AAb+ subjects and patients with T1D. Yet, whether the regulatory counterpart of Tfh cells, represented by T follicular regulatory (Tfr) cells, is similarly altered is still unclear. To address this question, we performed analyses in peripheral blood, spleen, and pancreatic lymph nodes (PLN) of organ donor subjects with T1D. Blood analyses were also performed in living AAb- and AAb+ subjects. While negligible differences in the frequency and phenotype of blood Tfr cells were observed among T1D, AAb-, and AAb+ adult subjects, the frequency of Tfr cells was significantly reduced in spleen and PLN of T1D as compared with nondiabetic control subjects. Furthermore, adoptive transfer of Tfr cells delayed disease development in a mouse model of T1D, a finding that could indicate that Tfr cells play an important role in peripheral tolerance and regulation of autoreactive Tfh cells. Together, our findings provide evidence of Tfr cell alterations within disease-relevant tissues in patients with T1D, suggesting a role for Tfr cells in defective humoral tolerance and disease pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Quality of medicine falling

Author

Ippolito, Elio and Hollow, Sleepy

Subjects
Health
Abstract

The article on recent reductions in physicians' work hours did not take into consideration the enormous decreases in the quality of those hours since more time is spent in paperwork, [...]

Published
2010

16. Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes

Author

Andrea Vecchione, Maria Pia Cicalese, Mariagrazia Favellato, Raffaela Melzi, Constantinos Petrovas, Elio Ippolito, Giuseppe Galvani, Kimberly Shankwitz, Eleonora Bianconi, Alessandro Aiuti, Angela Stabilini, Nichole Danzl, Manuela Battaglia, Roberta Di Fonte, Lorenzo Piemonti, Georgia Fousteri, Francesca Ragogna, Pauline Grogan, Emanuele Bosi, Rita Nano, Andrea Laurenzi, Todd M. Brusko, Jolanda Gerosa, Giulia Milardi, Tatiana Jofra, Howie R Seay, Amelia Caretto, Andrew R Schultz, Vecchione, Andrea, Jofra, Tatiana, Gerosa, Jolanda, Shankwitz, Kimberly, Di Fonte, Roberta, Galvani, Giuseppe, Ippolito, Elio, Cicalese, Maria Pia, Schultz, Andrew R, Seay, Howie R, Favellato, Mariagrazia, Milardi, Giulia, Stabilini, Angela, Ragogna, Francesca, Grogan, Pauline, Bianconi, Eleonora, Laurenzi, Andrea, Caretto, Amelia, Nano, Rita, Melzi, Raffaela, Danzl, Nichole, Bosi, Emanuele, Piemonti, Lorenzo, Aiuti, Alessandro, Brusko, Todd, Petrovas, Constantino, Battaglia, Manuela, and Fousteri, Georgia

Subjects
Adult, Adoptive cell transfer, endocrine system, Endocrinology, Diabetes and Metabolism, Cell, Spleen, Mice, SCID, T-Lymphocytes, Regulatory, Pancreatic Lymph Node, Mice, Mice, Inbred NOD, Follicular phase, Internal Medicine, medicine, Animals, Humans, Lymphocyte Count, Pancreas, Cells, Cultured, Type 1 diabetes, business.industry, Autoantibody, Peripheral tolerance, medicine.disease, Mice, Inbred C57BL, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Case-Control Studies, Immunology, Lymph Nodes, Immunology and Transplantation, business
Abstract

In the attempt to understand the origin of autoantibody (AAb) production in patients with and at-risk for T1D, multiple studies have analyzed and reported alterations in follicular helper T cells (Tfh) in presymptomatic AAb-positive subjects and patients with T1D. Yet, it is still not clear whether the regulatory counterpart of Tfh cells, represented by follicular regulatory T cells (Tfr), is similarly altered. To address this question, we performed analyses in peripheral blood, spleen and pancreatic lymph nodes (PLN) of organ donor subjects with T1D. Blood analyses were also performed in living AAb-negative and -positive subjects. While negligible differences in the frequency and phenotype of blood Tfr cells were observed between T1D, AAb-negative and AAb-positive adult subjects, the frequency of Tfr cells was significantly reduced in spleen and PLN of T1D as compared to non-diabetic controls. Furthermore, adoptive transfer of Tfr cells delayed disease development in a mouse model of T1D, a finding that could indicate that Tfr cells play an important role in peripheral tolerance and regulation of autoreactive Tfh cells. Together, our findings provide evidence of Tfr cell alterations within disease-relevant tissues in patients with T1D suggesting a role for Tfr cells in defective humoral tolerance and disease pathogenesis.

Published
2021

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