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4. Micro-nanoplastics and cardiovascular diseases: evidence and perspectives.

Author

Prattichizzo, Francesco, Ceriello, Antonio, Pellegrini, Valeria, Grotta, Rosalba La, Graciotti, Laura, Olivieri, Fabiola, Paolisso, Pasquale, D'Agostino, Bruno, Iovino, Pasquale, Balestrieri, Maria Luisa, Rajagopalan, Sanjay, Landrigan, Philip J, Marfella, Raffaele, and Paolisso, Giuseppe

Subjects
EPICARDIAL adipose tissue, ADIPOSE tissues, CELLULAR aging, BLOOD platelet aggregation, CHEMICAL decomposition, ATHEROSCLEROTIC plaque
Abstract

Emerging evidence indicates that chemical exposures in the environment are overlooked drivers of cardiovascular diseases (CVD). Recent evidence suggests that micro- and nanoplastic (MNP) particles derived largely from the chemical or mechanical degradation of plastics might represent a novel CVD risk factor. Experimental data in preclinical models suggest that MNPs can foster oxidative stress, platelet aggregation, cell senescence, and inflammatory responses in endothelial and immune cells while promoting a range of cardiovascular and metabolic alterations that can lead to disease and premature death. In humans, MNPs derived from various plastics, including polyethylene and polyvinylchloride, have been detected in atherosclerotic plaques and other cardiovascular tissues, including pericardia, epicardial adipose tissues, pericardial adipose tissues, myocardia, and left atrial appendages. MNPs have measurable levels within thrombi and seem to accumulate preferentially within areas of vascular lesions. Their presence within carotid plaques is associated with subsequent increased incidence of cardiovascular events. To further investigate the possible causal role of MNPs in CVD, future studies should focus on large, prospective cohorts assessing the exposure of individuals to plastic-related pollution, the possible routes of absorption, the existence of a putative safety limit, the correspondence between exposure and accumulation in tissues, the timing between accumulation and CVD development, and the pathophysiological mechanisms instigated by pertinent concentrations of MNPs. Data from such studies would allow the design of preventive, or even therapeutic, strategies. Meanwhile, existing evidence suggests that reducing plastic production and use will produce benefits for the environment and for human health. This goal could be achieved through the UN Global Plastics Treaty that is currently in negotiation. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Microplastics and Nanoplastics in Atheromas and Cardiovascular Events

Author

Marfella, Raffaele, primary, Prattichizzo, Francesco, additional, Sardu, Celestino, additional, Fulgenzi, Gianluca, additional, Graciotti, Laura, additional, Spadoni, Tatiana, additional, D’Onofrio, Nunzia, additional, Scisciola, Lucia, additional, La Grotta, Rosalba, additional, Frigé, Chiara, additional, Pellegrini, Valeria, additional, Municinò, Maurizio, additional, Siniscalchi, Mario, additional, Spinetti, Fabio, additional, Vigliotti, Gennaro, additional, Vecchione, Carmine, additional, Carrizzo, Albino, additional, Accarino, Giulio, additional, Squillante, Antonio, additional, Spaziano, Giuseppe, additional, Mirra, Davida, additional, Esposito, Renata, additional, Altieri, Simona, additional, Falco, Giovanni, additional, Fenti, Angelo, additional, Galoppo, Simona, additional, Canzano, Silvana, additional, Sasso, Ferdinando C., additional, Matacchione, Giulia, additional, Olivieri, Fabiola, additional, Ferraraccio, Franca, additional, Panarese, Iacopo, additional, Paolisso, Pasquale, additional, Barbato, Emanuele, additional, Lubritto, Carmine, additional, Balestrieri, Maria L., additional, Mauro, Ciro, additional, Caballero, Augusto E., additional, Rajagopalan, Sanjay, additional, Ceriello, Antonio, additional, D’Agostino, Bruno, additional, Iovino, Pasquale, additional, and Paolisso, Giuseppe, additional

Published
2024
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16. Formulation of Solid Lipid Nanoparticles Loaded with Nociceptin/Orphanin FQ (N/OFQ) and Characterization in a Murine Model of Airway Hyperresponsiveness

Author

Mirra, Davida, primary, Spaziano, Giuseppe, additional, Esposito, Renata, additional, Santonocito, Debora, additional, Filosa, Rosanna, additional, Roviezzo, Fiorentina, additional, Malgieri, Gaetano, additional, D’Abrosca, Gianluca, additional, Iovino, Pasquale, additional, Gallelli, Luca, additional, Fattorusso, Roberto, additional, Puglia, Carmelo, additional, and D’Agostino, Bruno, additional

Published
2022
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37. Evidence of Macromolecular Structure of Humic Acids from Compost.

Author

Capasso, Sante, Salvestrini, Stefano, and Iovino, Pasquale

Subjects
ELEMENTAL analysis, HUMIC acid, MOLECULAR structure, GLOBULAR proteins, SMALL molecules, MONOCARBOXYLIC acids
Abstract

Humic acids (HA) from compost of domestic-waste origin were characterized by IR and UV-Vis spectra and by elemental analysis. The molecular structure was investigated by treatment with the monocarboxylic acid HCOOH and CH3COOH, dialysis experiments and size-exclusion chromatography (SEC). In contrast to former reports, HCOOH and CH3COOH caused the simple precipitation of HA. SEC experiments gave chromatograms with a broad peak, with an elution volume at the maximum height of the peak very close to that of the globular protein bovine serum albumin, a value slightly above the fractional range of the gel used for SEC tests. The chromatogram profile was found to be independent on HA concentration. The eluted fractions exhibited sharper peaks than the pristine HA sample. It can be concluded that the HA extracted from compost do not consist of relatively small molecules held together by weak intermolecular interactions (as reported in the literature), but rather have a canonical macromolecular structure. The simple approach employed here is proposed as a reference procedure for testing the chemical structure of humic acids of any origin. [ABSTRACT FROM AUTHOR]

Published
2021

40. Photolysis treatment of Triclosan in water

Author

IOVINO, Pasquale, MUSMARRA, Dino, Chianese, Simeone, Leone, Vincenzo, Prisciandaro, Marina, AA.VV., Iovino, Pasquale, Chianese, Simeone, Leone, Vincenzo, Prisciandaro, Marina, and Musmarra, Dino

Published
2016

41. Sorption of organic pollutants onto a humic acids-zeolitic tuff adduct

Author

Leone, Vincenzo, IOVINO, Pasquale, Capasso, Santo, Chianese, Simeone, MUSMARRA, Dino, AA.VV., Leone, Vincenzo, Iovino, Pasquale, Capasso, Santo, Chianese, Simeone, and Musmarra, Dino

Subjects
Isosteric enthalpy, Sorption, Non-ionic organic pollutant, Humic acids-zeolitic tuff adduct
Published
2016

42. Diclofenac nelle acque: fotolisi e rimozione mediante processi di adsorbimento

Author

Claudia Esposito, Leone Vincenzo, Paola Vanore, SALVESTRINI, Stefano, CAPASSO, Sante, IOVINO, Pasquale, Claudia Esposito, Stefano Salvestrini, Leone Vincenzo, Paola Vanore, Sante Capasso, Pasquale Iovino, Claudia, Esposito, Salvestrini, Stefano, Leone, Vincenzo, Paola, Vanore, Capasso, Sante, and Iovino, Pasquale

Published
2015

43. New Perspectives for Smart Water Network monitoring, partitioning and protection with innovative On-line Measuring Sensors

Author

DI NARDO, Armando, CAPASSO, Sante, CASCETTA, Furio, DI NATALE, Michele, GRECO, Roberto, IOVINO, Pasquale, MUSMARRA, Dino, SOLDOVIERI, Francesco, VENTICINQUE, Salvatore, Alcocer Yamanaka, V. H., Altucci, C., Battaglia, R., Bernini, R., Bodini, S., Bortone, I., Bourguett Orti, V. J., Cammissa, A., Cocco, M., D’Acunto, M., Della Ventura, B., De Martino, F, Di Mauro, A., Doveri, M., El Mansouri, B., Funari, R., Gesuele, F., Koenig, R., Korakis, T., Laspidou, C. S., Lupi, L., Maietta, M., Paleari, O., Santonastaso, G. F., Savic, D., Scozzari, A., Smorra, F., Tuccinardi, F. P., Tzatchkov, V. G., Vamvakeridou lyroudia, L. S., Velotta, R., Vetrano, B., AAVV, DI NARDO, Armando, Alcocer Yamanaka, V. H., Altucci, C., Battaglia, R., Bernini, R., Bodini, S., Bortone, I., Bourguett Orti, V. J., Cammissa, A., Capasso, Sante, Cascetta, Furio, Cocco, M., D’Acunto, M., Della Ventura, B., De Martino, F, Di Mauro, A., DI NATALE, Michele, Doveri, M., El Mansouri, B., Funari, R., Gesuele, F., Greco, Roberto, Iovino, Pasquale, Koenig, R., Korakis, T., Laspidou, C. S., Lupi, L., Maietta, M., Musmarra, Dino, Paleari, O., Santonastaso, G. F., Savic, D., Scozzari, A., Soldovieri, Francesco, Smorra, F., Tuccinardi, F. P., Tzatchkov, V. G., Vamvakeridou lyroudia, L. S., Velotta, R., Venticinque, Salvatore, and Vetrano, B.

Published
2015

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