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2 results on '"Ionova, Klavdiya P."'

1. Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer

Author

Semkina, Alevtina S., primary, Abakumov, Maxim A., additional, Skorikov, Alexander S., additional, Abakumova, Tatiana O., additional, Melnikov, Pavel A., additional, Grinenko, Nadejda F., additional, Cherepanov, Sergey A., additional, Vishnevskiy, Daniil A., additional, Naumenko, Victor A., additional, Ionova, Klavdiya P., additional, Majouga, Alexander G., additional, and Chekhonin, Vladimir P., additional

Published
2018
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2. Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer.

Author

Semkina AS, Abakumov MA, Skorikov AS, Abakumova TO, Melnikov PA, Grinenko NF, Cherepanov SA, Vishnevskiy DA, Naumenko VA, Ionova KP, Majouga AG, and Chekhonin VP

Subjects
Animals, Antibiotics, Antineoplastic administration & dosage, Antibiotics, Antineoplastic chemistry, Doxorubicin administration & dosage, Doxorubicin chemistry, Drug Delivery Systems, Female, Magnetite Nanoparticles chemistry, Mammary Neoplasms, Experimental metabolism, Mammary Neoplasms, Experimental pathology, Mice, Mice, Inbred BALB C, Multimodal Imaging, Rats, Rats, Wistar, Antibiotics, Antineoplastic pharmacology, Doxorubicin pharmacology, Magnetite Nanoparticles administration & dosage, Mammary Neoplasms, Experimental drug therapy, Theranostic Nanomedicine methods, Vascular Endothelial Growth Factor A antagonists & inhibitors
Abstract

In presented paper we have developed new system for cancer theranostics based on vascular endothelial growth factor (VEGF) targeted magnetic nanoparticles. Conjugation of anti-VEGF antibodies with bovine serum albumin coated PEGylated magnetic nanoparticles allows for improved binding with murine breast adenocarcinoma 4T1 cell line and facilitates doxorubicin delivery to tumor cells. It was shown that intravenous injection of doxorubicin loaded VEGF targeted nanoparticles increases median survival rate of mice bearing 4T1 tumors up to 50%. On the other hand magnetic resonance imaging (MRI) of 4T1 tumors 24 h after intravenous injection showed accumulation of nanoparticles in tumors, thus allowing simultaneous cancer therapy and diagnostics., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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