88 results on '"Iolanda Cioffi"'
Search Results
2. Lentils based pasta affect satiation, satiety and food intake in healthy volunteers
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Iolanda Cioffi, Daniela Martini, Cristian Del Bo’, Antonella Brusamolino, Maria Cristina Casiraghi, Marisa Porrini, and Patrizia Riso
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Pulses ,Appetite ,Satiation ,Overweight ,Eating behavior ,Sex difference ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Plant-based diets represent a valid strategy to improve human health and increase food sustainability. The availability of legume-based products, a good source of proteins and fibers, could help consumers to promote healthy dietary patterns. The aim of this study was to examine the impact of different legume-based pastas on energy intake and appetite in healthy volunteers. Four ad libitum (protocol 1) and iso-caloric pre-load meals (protocol 2) were tested using a randomized repeated measure design. The test meals consisted of lentils pasta (LP), chickpeas pasta (CP); durum wheat pasta (DWP) and gluten free pasta (GFP), served with tomato sauce. Protocol 1: the ad libitum lunch meal was consumed then EI registered. Protocol 2: subjective appetite was assessed by visual analogue scale before and after the pre-load meal for 2 h until an ad libitum buffet was served to assess EI. Twenty (age: 39.2 ± 8.41 years; BMI: 23.4 ± 3.4 kg/m2) and 40 (age: 42.6 ± 8.7 years; BMI: 23.8 ± 4.2 kg/m2) healthy subjects were respectively recruited for each protocol. ANCOVA analysis showed an overall effect of meals and sex on EI within meal and at the subsequent meal, resulting in a lower EI after LP compared to DWP (p
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- 2024
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3. Amino acid profiles, disease activity, and protein intake in adult patients with Crohn’s disease
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Iolanda Cioffi, Olivia Di Vincenzo, Nicola Imperatore, Mariagrazia Fisco, Anna Testa, Filippo Scialò, Fabiana Castiglione, Margherita Ruoppolo, Fabrizio Pasanisi, and Lidia Santarpia
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glutamine ,tryptophan ,interleukin-1 ,inflammatory bowel disease ,nutritional status ,Nutrition. Foods and food supply ,TX341-641 - Abstract
IntroductionCrohn’s disease (CD) is an immune-mediated inflammatory disorder of the gastrointestinal tract with a relapsing–remitting course. Amino acids (AAs) may play critical roles in the intestinal manifestations of disease, due to their involvement in many metabolic and immune functions. The present study aimed to explore serum AA concentrations in adult patients with CD, looking into their variations due to disease activity, surgery and protein content of diet. Eventually, the link between AAs and inflammatory markers was also assessed.MethodsConsecutive adult patients aged 18–65 years with diagnosis of CD were recruited. All participants underwent anthropometry and were instructed to fill in a 3-day food record to assess protein intake. Disease activity was clinically defined using the Crohn’s Disease Activity Index (CDAI), while blood samples were taken to analyze serum AA profile and inflammatory markers.ResultsA total of 103 patients with CD (61 men and 42 women; age:39.9 ± 13.9 years, BMI: 23.4 ± 3.51 kg/m2) were included. Tryptophan levels were found to be remarkably decreased in most subjects, unrelated to disease activity. On the contrary, concentration of lysine, leucine, valine and glutamine decreased in active versus quiescent CD patients, while aspartic acid, glutamate and glycine increased. The latter AAs were also directly correlated with CDAI and serum interleukin (IL)- 1β concentration. Considering the total protein intake, expressed as g/kg/body weight, we observed a reduction in some essential AAs in patients with unmet protein requirements compared to patients who met the recommendation.DiscussionIn conclusion, specific AAs varied according to disease activity and protein intake, adjusted to body weight and disease status. Glu and Asp concentrations raised with increasing IL-1β. However, extensive research is needed to understand the mechanisms underpinning the link between variation in serum AAs, disease activity and protein intake in patients with CD.
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- 2023
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4. Berry Dietary Interventions in Metabolic Syndrome: New Insights
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Samuele Venturi, Mirko Marino, Iolanda Cioffi, Daniela Martini, Cristian Del Bo’, Simone Perna, Patrizia Riso, Dorothy Klimis-Zacas, and Marisa Porrini
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blueberry ,raspberry ,strawberry ,cranberry ,humans ,dietary intervention ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Metabolic Syndrome (MetS) is characterized by a group of dysmetabolic conditions, including abdominal obesity, dyslipidemia, glucose intolerance and/or insulin resistance, and hypertension. Generally, MetS is accompanied by an exacerbation of oxidative stress, inflammation, and vascular dysfunction. Increasing evidence suggests that berries and berry bioactives could play a potential role in the prevention and mitigation of the risk factors associated with MetS. The present systematic review summarizes the more recently available evidence deriving from human intervention studies investigating the effect of berries in subjects with at least three out of five MetS parameters. The PubMed, Scopus, and Embase databases were systematically searched from January 2010 until December 2022. A total of 17 human intervention trials met the inclusion criteria. Most of them were focused on blueberry (n = 6), cranberry (n = 3), and chokeberry (n = 3), while very few or none were available for the other berries. If considering MetS features, the main positive effects were related to lipid profile (low and high-density lipoproteins, cholesterol, and triglycerides) following blueberries and chokeberries, while conflicting results were documented for anthropometric parameters, blood pressure, and fasting blood glucose levels. Other markers analyzed within the studies included vascular function, oxidative stress, and inflammation. Here, the main positive effects were related to inflammation with a reduction in interleukin 6 and tumor necrosis factor-alpha following the intake of different berries. In conclusion, although limited, the evidence seems to support a potential role for berries in the modulation of lipid profile and inflammation in subjects with MetS. Furthermore, high-quality intervention trials are mandatory to demonstrate the role of berries in reducing risk factors for MetS and related conditions. In the future, such a demonstration could bring the adoption of berries as a potential dietary strategy to prevent/counteract MetS and related risk factors.
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- 2023
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5. Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn’s Disease
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Iolanda Cioffi, Filippo Scialò, Olivia Di Vincenzo, Monica Gelzo, Maurizio Marra, Anna Testa, Fabiana Castiglione, Maria Vitale, Fabrizio Pasanisi, and Lidia Santarpia
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inflammatory bowel disease ,malnutrition ,CONUT score ,phase angle ,c reactive protein ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Crohn’s disease (CD) is a chronic inflammatory disorder that may occur in any segment of the gastrointestinal tract. Asymptomatic or untreated inflammation along with malnutrition can often coexist in patients with CD, impairing clinical outcomes, therefore the aim of this study was to assess the relationship between inflammation, malnutrition risk and nutritional status in CD patients. Consecutive adult CD outpatients aged 18-65 years were recruited. Disease activity was clinically defined by the Crohn’s Disease Activity Index (CDAI), whilst anthropometry and phase angle (PhA) were measured. The Controlling Nutritional Status (CONUT) score was retrospectively calculated for screening malnutrition risk and blood samples were taken. A total of 140 CD patients with a mean age of 38.8 ± 13.9 years and an average weight of 64.9 ± 12.0 kg were included. Serum interleukin (IL)-6 concentration was increased in active-CD patients, unrelated to medical treatment, which was associated with CDAI and PhA. Based on the CONUT score, the prevalence of patients with moderate/severe malnutrition risk (score ≥ 5) was 10%, showing lower age, body mass index and fat mass, but higher IL-6 and IL-1β levels than subjects classified as not at risk (score 0–1). Finally, increased IL-6 levels and reduced PhA values were identified as independent predictors of moderate/severe malnutrition risk (p < 0.05). In conclusion, IL-6 increased in active-CD patients, which was inversely correlated with PhA. Although the CONUT score might be helpful for identifying CD patients at moderate/severe risk of malnutrition, larger studies are needed to verify these results in different settings.
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- 2023
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6. Resting energy expenditure in elite athletes: development of new predictive equations based on anthropometric variables and bioelectrical impedance analysis derived phase angle
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Maurizio Marra, Olivia Di Vincenzo, Iolanda Cioffi, Rosa Sammarco, Delia Morlino, and Luca Scalfi
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athletes ,energy expenditure ,predictive equations ,bia ,phase angle ,accuracy ,Nutrition. Foods and food supply ,TX341-641 ,Sports medicine ,RC1200-1245 - Abstract
Background An accurate estimation of athletes’ energy needs is crucial in diet planning to improve sport performance and to maintain an appropriate body composition. This study aimed to develop and validate in elite athletes new equations for estimating resting energy expenditure (REE) based on anthropometric parameters as well as bioimpedance analysis (BIA)-derived raw variables and to validate the accuracy of selected predictive equations. Methods Adult elite athletes aged 18–40 yrs were studied. Anthropometry, indirect calorimetry and BIA were performed in all subjects. The new predictive equations were generated using different regression models. The accuracy of the new equations was assessed at the group level (bias) and at the individual level (precision accuracy), and then compared with the one of five equations used in the general population or three athletes-specific formulas. Results One-hundred and twenty-six male athletes (age 26.9 ± 9.1 yrs; weight 71.3 ± 10.9 kg; BMI 22.8 ± 2.7 kg/m2) from different sport specialties were randomly assigned to the calibration (n = 75) or validation group (n = 51). REE was directly correlated with individual characteristics, except for age, and raw BIA variables. Most of the equations from the literature were reasonably accurate at the population level (bias within ±5%). The new equations showed a mean bias −0.3% (Eq. A based on anthropometric parameters) and −0.6% (Eq. B based on BIA-derived raw variables). Precision accuracy (individual predicted-measured differences within ±5%) was ~75% in six out of eight of the selected equations and even higher for Eq. A (82.4%) and Eq. B (92.2%). Conclusion In elite athletes, BIA-derived phase angle is a significant predictor of REE. The new equations have a very good prediction accuracy at both group and individual levels. The use of phase angle as predictor of REE requires further research with respect to different sport specialties, training programs and training level.
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- 2021
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7. Intermittent versus continuous energy restriction on weight loss and cardiometabolic outcomes: a systematic review and meta-analysis of randomized controlled trials
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Iolanda Cioffi, Andrea Evangelista, Valentina Ponzo, Giovannino Ciccone, Laura Soldati, Lidia Santarpia, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo, and Simona Bo
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Continuous energy restriction ,Intermittent energy restriction ,Fasting glucose ,Triglycerides ,Weight loss ,Medicine - Abstract
Abstract Background This systematic review and meta-analysis summarized the most recent evidence on the efficacy of intermittent energy restriction (IER) versus continuous energy restriction on weight-loss, body composition, blood pressure and other cardiometabolic risk factors. Methods Randomized controlled trials were systematically searched from MEDLINE, Cochrane Library, TRIP databases, EMBASE and CINAHL until May 2018. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). Results Eleven trials were included (duration range 8–24 weeks). All selected intermittent regimens provided ≤ 25% of daily energy needs on “fast” days but differed for type of regimen (5:2 or other regimens) and/or dietary instructions given on the “feed” days (ad libitum energy versus balanced energy consumption). The intermittent approach determined a comparable weight-loss (WMD: − 0.61 kg; 95% CI − 1.70 to 0.47; p = 0.87) or percent weight loss (WMD: − 0.38%, − 1.16 to 0.40; p = 0.34) when compared to the continuous approach. A slight reduction in fasting insulin concentrations was evident with IER regimens (WMD = − 0.89 µU/mL; − 1.56 to − 0.22; p = 0.009), but the clinical relevance of this result is uncertain. No between-arms differences in the other variables were found. Conclusions Both intermittent and continuous energy restriction achieved a comparable effect in promoting weight-loss and metabolic improvements. Long-term trials are needed to draw definitive conclusions.
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- 2018
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8. Prevalence of Sarcopenia in Women with Breast Cancer
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Delia Morlino, Maurizio Marra, Iolanda Cioffi, Lidia Santarpia, Pietro De Placido, Mario Giuliano, Carmine De Angelis, Simone Carrano, Annarita Verrazzo, Giuseppe Buono, Marianna Naccarato, Olivia Di Vincenzo, Enza Speranza, Sabino De Placido, Grazia Arpino, and Fabrizio Pasanisi
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breast cancer ,sarcopenia ,body composition ,bioimpedance analysis (BIA) ,hand grip strength (HGS) ,phase angle (PhA) ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Sarcopenia is a common finding in patients with cancer and potentially influences the patient’s outcome. The aim of this study was to evaluate the prevalence of sarcopenia, according to the European Working Group on Sarcopenia in Older People, in a sample of women with breast cancer (BC) and a BMI lower than 30 kg/m2. This cross-sectional study was conducted in patients with BC, stage 0-III, and receiving therapy for BC; the women were recruited at the Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. A control group with similar age and BMI was selected from the internal database. Anthropometry, bioimpedance analysis (BIA) and hand grip strength (HGS) were measured to detect sarcopenia. A total of 122 patients (mean age 49.3 ± 11.0 years, BMI 24.6 ± 3.0 kg/m2) and 80 healthy controls were analyzed. Sarcopenia was found in 13.9% patients with BC, while none of the subjects in the control group was sarcopenic. By comparing BC patients with and without sarcopenia and the control group, the fat-free mass of sarcopenic BC patients were significantly lower than those of both non-sarcopenic BC patients and the control (p < 0.05). The phase angle was also significantly lower in sarcopenic patients (−0.5 degrees, p = 0.048) than in the control group. Considering the prevalence of sarcopenia in patients with BC, our findings suggest the usefulness of body composition and HGS evaluation for early screening of sarcopenia to reduce the risk of associated complications.
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- 2022
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9. Association between Health-Related Quality of Life and Nutritional Status in Adult Patients with Crohn’s Disease
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Iolanda Cioffi, Nicola Imperatore, Olivia Di Vincenzo, Lidia Santarpia, Antonio Rispo, Maurizio Marra, Anna Testa, Franco Contaldo, Fabiana Castiglione, and Fabrizio Pasanisi
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quality of life ,muscle strength ,nutritional assessment ,inflammatory bowel disease ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This study aimed to assess health related quality of life (HRQoL) in adult patients with Crohn’s disease (CD), considering disease severity and gender differences, and also its relationship with nutritional status. Consecutive adult patients aged 18−65 years with CD were recruited. Disease activity was clinically defined by the Crohn’s Disease Activity Index (CDAI) in active and quiescent phases. HRQoL was evaluated using the validated short form (SF)-36 questionnaire for the Italian population. Additionally, anthropometry, bioimpedance analysis, and handgrip-strength (HGS) were performed. Findings showed that 135 patients (79 men and 56 women) were included, having a mean age of 38.8 ± 14 years and a BMI of 23.2 ± 3.7 kg/m2. Overall, active CD patients had a lower perception of their QoL compared to those clinically quiescent, while gender differences emerged mostly in the quiescent group. Interestingly, HRQoL was significantly associated with many nutritional variables, and muscle strength was the main predictor. Therefore, HRQoL is perceived lower in active compared to quiescent patients, but women experienced poorer QoL than men, especially in the quiescent phase. Finally, higher QoL scores were found in subjects being in clinical remission phase with a preserved muscle function. However, further studies are still required to verify these findings.
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- 2020
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10. Macronutrients in Parenteral Nutrition: Amino Acids
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Roberto Iacone, Clelia Scanzano, Lidia Santarpia, Iolanda Cioffi, Franco Contaldo, and Fabrizio Pasanisi
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amino acid ,parenteral nutrition ,essential amino acid ,amino acid requirement ,nitrogen balance ,energy requirement ,Nutrition. Foods and food supply ,TX341-641 - Abstract
The right amount and quality of amino acids (AAs) supplied to patients on parenteral nutrition (PN) reduces muscle mass loss, may preserve or even increase it, with significant clinical benefits. Several industrial PN mixtures are available so that nutrition specialists can choose the product closest to the patient’s needs. In selected cases, there is the possibility of personalizing compounded mixtures in a hospital pharmacy that completely meets the individual nutritional needs of PN patients. This narrative review deals with the AA solutions used in PN mixtures. The physiology, the methods to calculate the AA needs, and the AA and energy requirements suggested by scientific guidelines for each patient type are also reported.
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- 2020
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11. Nutrition Transition and Cancer
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Franco Contaldo, Lidia Santarpia, Iolanda Cioffi, and Fabrizio Pasanisi
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nutrition ,non-communicable diseases ,cancer ,human health ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Urbanization, population aging, and climatic changes have mostly contributed to nutrition transition and, consequently, to effects of food habits on the epidemic of chronic non-communicable diseases (NCDs), especially cancer. Climatic changes are negatively affecting crop production, particularly biodiversity, leading to reduced food choices and, consequently, nutritional value and the protection conferred from consumption of a variety of nutrients essential in a healthy diet. This brief review analyzes the possible link between rapid demographic changes, climatic and environmental crises, and the current food system as possible factors contributing to the role of nutrition transition in the onset of cancer.
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- 2020
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12. Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study
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Enza Speranza, Iolanda Cioffi, Lidia Santarpia, Concetta Del Piano, Carmela De Caprio, Marianna Naccarato, Maurizio Marra, Emilia De Filippo, Franco Contaldo, and Fabrizio Pasanisi
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anorexia nervosa ,SCFA ,malnutrition ,energy expenditure ,diet ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Nutritional disorders such as Anorexia Nervosa (AN) can shape the composition of gut microbiota and its metabolites such as short chain fatty acid (SCFA). This study aims to compare fecal SCFA along with dietary intake of women with restrictive AN (r-AN = 10) and those of sex-matched lean controls (C = 8). The main fecal short chain fatty acids (SCFA) were assessed by gas chromatography equipped with a flame ionization detector. All participants completed 7-day food record and underwent indirect calorimetry for measuring resting energy expenditure (REE). Butyrate and propionate fecal concentrations were significantly reduced in r-AN patients compared to controls. The intake of carbohydrate and fat was significantly lower in r-AN patients than controls as well as energy intake and REE; whereas the amount of protein and fiber did not differ between groups. These preliminary results showed that r-AN patients had a reduced excretion of fecal SCFA, likely as a mechanism to compensate for the lower energy and carbohydrate intake observed between groups. Therefore, further studies need to be performed in patients with AN to explore the link between nutritional disorders, gut microbiota and its metabolites.
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- 2018
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13. Are Raw BIA Variables Useful for Predicting Resting Energy Expenditure in Adults with Obesity?
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Maurizio Marra, Iolanda Cioffi, Rosa Sammarco, Lidia Santarpia, Franco Contaldo, Luca Scalfi, and Fabrizio Pasanisi
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obesity ,basal metabolic rate ,body composition ,phase angle ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This study aimed to develop and validate new predictive equations for resting energy expenditure (REE) in a large sample of subjects with obesity also considering raw variables from bioimpedance-analysis (BIA). A total of 2225 consecutive obese outpatients were recruited and randomly assigned to calibration (n = 1680) and validation (n = 545) groups. Subjects were also split into three subgroups according to their body mass index (BMI). The new predictive equations were generated using two models: Model 1 with age, weight, height, and BMI as predictors, and Model 2 in which raw BIA variables (bioimpedance-index and phase angle) were added. Our results showed that REE was directly correlated with all anthropometric and raw-BIA variables, while the correlation with age was inverse. All the new predictive equations were effective in estimating REE in both sexes and in the different BMI subgroups. Accuracy at the individual level was high for specific group-equation especially in subjects with BMI > 50 kg/m2. Therefore, new equations based on raw-BIA variables were as accurate as those based on anthropometry. Equations developed for BMI categories did not substantially improve REE prediction, except for subjects with a BMI > 50 kg/m2. Further studies are required to verify the application of those formulas and the role of raw-BIA variables for predicting REE.
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- 2019
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14. Relationship between Handgrip Strength, Anthropometric and Body Composition Variables in Different Athletes.
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Olivia Di Vincenzo, Maurizio Marra, Delia Morlino, Enza Speranza, Rosa Sammarco, Iolanda Cioffi, and Luca Scalfi
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- 2020
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15. Resting Energy Expenditure in Elite Female Athletes of Different Sports.
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Olivia Di Vincenzo, Maurizio Marra, Delia Morlino, Enza Speranza, Rosa Sammarco, Iolanda Cioffi, and Luca Scalfi
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- 2020
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16. Global fertility in 204 countries and territories, 1950-2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
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V Bhattacharjee, N, E Schumacher, A, Aali, A, Habtegiorgis Abate, Y, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abd-Elsalam, S, Abdollahi, M, Abdollahifar, M, Abdoun, M, Abdullahi, A, Abebe, M, Shawel Abebe, S, Abiodun, O, Abolhassani, H, Abolmaali, M, Abouzid, M, Beressa Aboye, G, Guimarães Abreu, L, Aberhe Abrha, W, M Abrigo, M, Abtahi, D, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Me Abu-Rmeileh, N, Girum Girum Adal, T, Molla Adane, M, Atanda Adeagbo Adeagbo, O, Adesoji Adedoyin, R, Adekanmbi, V, Aden, B, Victor Adepoju, A, O Adetokunboh, O, Bunmi Adetunji, J, Adedayo Adeyinka, D, Israel Adeyomoye, O, Estiningtyas Sakilah Adnani, Q, Adra, S, Felix Afolabi, R, Afyouni, S, Sohail Afzal, M, Afzal, S, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Opoku Ahinkorah, B, J Ahlstrom, A, Ahmad, A, Ahmad, D, Ahmad, F, M Ahmad, M, Ahmad, S, Ahmad, T, Ahmed, A, Ahmed, H, A Ahmed, L, Saleh Ahmed, M, Anees Ahmed, S, Ajami, M, Aji, B, Taddesse Akalu, G, Akbarialiabad, H, Olusola Akinyemi, R, Ahmed Akkaif, M, Akkala, S, Al Hamad, H, Mahfuz Al Hasan, S, Al Qadire, M, Mohammed Ali Al-Ahdal, T, O Alalalmeh, S, A Alalwan, T, Al-Aly, Z, Alam, K, Mustafa Al-Amer, R, Mashhour Alanezi, F, M Alanzi, T, Albakri, A, Albashtawy, M, T AlBataineh, M, Alemi, H, Alemi, S, Mulugeta Alemu, Y, Al-Eyadhy, A, Ali Saeed Al-Gheethi, A, F Alhabib, K, Alhajri, N, Alhalaiqa Naji Alhalaiqa, F, Kaba Alhassan, R, Ali, A, Abdulqadir Ali, B, Ali, L, Usman Ali, M, Ali, R, Shujait Shujait Ali, S, Mohammad Alif, S, Aligol, M, Alijanzadeh, M, M Aljasir, M, Mohamed Aljunid, S, Al-Marwani, S, Uy Almazan, J, M Al-Mekhlafi, H, Almidani, O, A Alomari, M, Al-Omari, B, S Alqahtani, J, Yaseen Alqutaibi, A, M Al-Raddadi, R, Khalifah Al-Sabah, S, Altaf, A, A Al-Tawfiq, J, A Altirkawi, K, Oyine Aluh, D, Jawad Alvi, F, Alvis-Guzman, N, Alwafi, H, Mohammed Al-Worafi, Y, Aly, H, Aly, S, H Alzoubi, K, Kwabena Ameyaw, E, Tawfik Amin, T, Amindarolzarbi, A, Amini-Rarani, M, Amiri, S, Gyamfuah Ampomah, I, A Amugsi, D, Adeniyi Amusa, G, Ancuceanu, R, Anderlini, D, Prata Andrade, P, Liliana Andrei, C, Andrei, T, Anil, A, Anil, S, Ansar, A, Ansari-Moghaddam, A, M Antony, C, Antriyandarti, E, Anvari, S, Anwar, S, Anwer, R, Edward Anyasodor, A, Arabloo, J, Arabzadeh Bahri, R, A Arafa, E, Arafat, M, Margarida Araújo, A, Y Aravkin, A, Aremu, A, Aripov, T, Arkew, M, Armocida, B, Ärnlöv, J, Arooj, M, A Artamonov, A, Arulappan, J, Taiwo Aruleba, R, Arumugam, A, Asadi-Lari, M, Asemi, Z, Asgary, S, Asghariahmadabad, M, Asghari-Jafarabadi, M, Yesse Ashemo, M, Ashraf, M, Ashraf, T, O Asika, M, Shamsadin Athari, S, Moh'd Wahbi Atout, M, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Mulat Aweke, A, Melaku Ayele, G, Mohammad Ayyoubzadeh, S, Azadnajafabad, S, S Azevedo, R, Y Azzam, A, Badar, M, D Badiye, A, Baghdadi, S, Bagheri, N, Bagherieh, S, Bahmanziari, N, Bai, R, Amin Baig, A, L Baker, J, T Bako, A, Kaur Bakshi, R, Balasubramanian, M, Constantin Baltatu, O, Bam, K, Banach, M, 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Saravi, Yaser Sarikhani, Tanmay Sarkar, Rodrigo Sarmiento-Suárez, Gargi Sachin Sarode, Sachin C Sarode, Arash Sarveazad, Brijesh Sathian, Thirunavukkarasu Sathish, Anudeep Sathyanarayan, Abu Sayeed, Md Abu Sayeed, Nikolaos Scarmeas, Winfried Schlee, Art Schuermans, David C Schwebel, Falk Schwendicke, Siddharthan Selvaraj, Pallav Sengupta, Subramanian Senthilkumaran, Sadaf G Sepanlou, Dragos Serban, Edson Serván-Mori, Yashendra Sethi, SeyedAhmad SeyedAlinaghi, Seyed Arsalan Seyedi, Allen Seylani, Mahan Shafie, Jaffer Shah, Pritik A Shah, Ataollah Shahbandi, Samiah Shahid, Moyad Jamal Shahwan, Ahmed Shaikh, Masood Ali Shaikh, Muhammad Aaqib Shamim, Mehran Shams-Beyranvand, Mohammad Anas Shamsi, Mohd Shanawaz, Abhishek Shankar, Mohammed Shannawaz, Medha Sharath, Sadaf Sharfaei, Amin Sharifan, Javad Sharifi-Rad, Manoj Sharma, Rajesh Sharma, Ujjawal Sharma, Vishal Sharma, Rajesh P Shastry, Amin Shavandi, David H Shaw, Amir Mehdi Shayan, Maryam Shayan, Amr Mohamed Elsayed Shehabeldine, Aziz Sheikh, Rahim Ali Sheikhi, Manjunath Mala Shenoy, Pavanchand H Shetty, Peilin Shi, Desalegn Shiferaw, Mika Shigematsu, Rahman Shiri, Reza Shirkoohi, Aminu Shittu, Velizar Shivarov, Farhad Shokraneh, Sina Shool, Seyed Afshin Shorofi, Kanwar Hamza Shuja, Kerem Shuval, Emmanuel Edwar Siddig, João Pedro Silva, Luís Manuel Lopes Rodrigues Silva, Soraia Silva, Biagio Simonetti, Anjali Singal, Abhinav Singh, Balbir Bagicha Singh, Jasvinder A Singh, Md Shahjahan Siraj, Georgia Smith, Bogdan Socea, Anton Sokhan, Ranjan Solanki, Shipra Solanki, Hamidreza Soleimani, Sameh S M Soliman, Yonatan Solomon, Yimeng Song, Reed J D Sorensen, Michael Spartalis, Chandrashekhar T Sreeramareddy, Vijay Kumar Srivastava, Muhammad Haroon Stanikzai, Vladimir I Starodubov, Antonina V Starodubova, Simona Cătălina Stefan, Paschalis Steiropoulos, Mark A Stokes, Vetriselvan Subramaniyan, Muhammad Suleman, Rizwan Suliankatchi Abdulkader, Abida Sultana, Jing Sun, Chandan Kumar Swain, Bryan L Sykes, Lukasz Szarpak, Mindy D Szeto, Miklós Szócska, Payam Tabaee Damavandi, Rafael Tabarés-Seisdedos, Ozra Tabatabaei Malazy, Seyed-Amir Tabatabaeizadeh, Shima Tabatabai, Karen M Tabb, Mohammad Tabish, Moslem Taheri Soodejani, Jabeen Taiba, Ardeshir Tajbakhsh, Iman M Talaat, Ashis Talukder, Mircea Tampa, Jacques Lukenze Tamuzi, Ker-Kan Tan, Haosu Tang, Derbie Alemu DA Tareke, Mengistie Kassahun Tariku, Vivian Y Tat, Seyed Mohammad Tavangar, Mojtaba Teimoori, Mohamad-Hani Temsah, Reem Mohamad Hani Temsah, Masayuki Teramoto, Dufera Rikitu Terefa, Riki Tesler, Enoch Teye-Kwadjo, Ramna Thakur, Pugazhenthan Thangaraju, Kavumpurathu Raman Thankappan, Rekha Thapar, Samar Tharwat, Rasiah Thayakaran, Nihal Thomas, Ales Tichopad, Jansje Henny Vera Ticoalu, Tenaw Yimer Tiruye, Mariya Vladimirovna Titova, Marcello Tonelli, Marcos Roberto Tovani-Palone, Eugenio Traini, Jasmine T Tran, Nghia Minh Tran, Indang Trihandini, Samuel Joseph Tromans, Thien Tan Tri Tai Truyen, Aristidis Tsatsakis, Evangelia Eirini Tsermpini, Munkhtuya Tumurkhuu, Stefanos Tyrovolas, Sayed Mohammad Nazim Uddin, Aniefiok John Udoakang, Arit Udoh, Atta Ullah, Saeed Ullah, Sana Ullah, Srikanth Umakanthan, Chukwuma David Umeokonkwo, Brigid Unim, Bhaskaran Unnikrishnan, Era Upadhyay, Jibrin Sammani Usman, Marco Vacante, Seyed Mohammad Vahabi, Asokan Govindaraj Vaithinathan, Rohollah Valizadeh, Jef Van den Eynde, Elena Varavikova, Orsolya Varga, Priya Vart, Shoban Babu Varthya, Tommi Juhani Vasankari, Balachandar Vellingiri, Deneshkumar Venugopal, Nicholas Alexander Verghese, Madhur Verma, Massimiliano Veroux, Georgios-Ioannis Verras, Dominique Vervoort, Jorge Hugo Villafañe, Manish Vinayak, Francesco S Violante, Mukesh Vishwakarma, Sergey Konstantinovitch Vladimirov, Vasily Vlassov, Bay Vo, Simona Ruxandra Volovat, Theo Vos, Isidora S Vujcic, Hatem A Wafa, Yasir Waheed, Elias Bekele Wakwoya, Cong Wang, Denny Wang, Fang Wang, Shu Wang, Yanzhong Wang, Yuan-Pang Wang, Paul Ward, Emebet Gashaw Wassie, Stefanie Watson, Marcia R Weaver, Kosala Gayan Weerakoon, Daniel J Weiss, Katherine M Wells, Yi Feng Wen, Ronny Westerman, Taweewat Wiangkham, Dakshitha Praneeth Wickramasinghe, Nuwan Darshana Wickramasinghe, Peter Willeit, Yohannes Addisu Wondimagegene, Felicia Wu, Juan Xia, Hong Xiao, Gelin Xu, Suowen Xu, Xiaoyue Xu, Ali Yadollahpour, Shirin Yaghoobpoor, Tina Yaghoobpour, Sajad Yaghoubi, Zwanden Sule Yahaya, Danting Yang, Lin Yang, Yuichiro Yano, Habib Yaribeygi, Pengpeng Ye, Renjulal Yesodharan, Subah Abderehim Yesuf, Saber Yezli, Amanuel Yigezu, Paul Yip, Dong Keon Yon, Naohiro Yonemoto, Yuyi You, Mustafa Z Younis, Zabihollah Yousefi, Chuanhua Yu, Yong Yu, Chun-Wei Yuan, Nima Zafari, Fathiah Zakham, Nazar Zaki, Giulia Zamagni, Milad Zandi, Ghazal G Z Zandieh, Moein Zangiabadian, Mikhail Sergeevich Zastrozhin, Haijun Zhang, Meixin Zhang, Yunquan Zhang, Chenwen Zhong, Juexiao Zhou, Bin Zhu, Lei Zhu, Magdalena Zielińska, Zhiyong Zou, Samer H Zyoud, Christopher J L Murray, Amanda E Smith, and Stein Emil Vollset
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Background: Accurate assessments of current and future fertility-including overall trends and changing population age structures across countries and regions-are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 produced up-to-date and comprehensive demographic assessments of key fertility indicators at global, regional, and national levels from 1950 to 2021 and forecast fertility metrics to 2100 based on a reference scenario and key policy-dependent alternative scenarios. Methods: To estimate fertility indicators from 1950 to 2021, mixed-effects regression models and spatiotemporal Gaussian process regression were used to synthesise data from 8709 country-years of vital and sample registrations, 1455 surveys and censuses, and 150 other sources, and to generate age-specific fertility rates (ASFRs) for 5-year age groups from age 10 years to 54 years. ASFRs were summed across age groups to produce estimates of total fertility rate (TFR). Livebirths were calculated by multiplying ASFR and age-specific female population, then summing across ages 10-54 years. To forecast future fertility up to 2100, our Institute for Health Metrics and Evaluation (IHME) forecasting model was based on projections of completed cohort fertility at age 50 years (CCF50; the average number of children born over time to females from a specified birth cohort), which yields more stable and accurate measures of fertility than directly modelling TFR. CCF50 was modelled using an ensemble approach in which three sub-models (with two, three, and four covariates variously consisting of female educational attainment, contraceptive met need, population density in
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- 2024
17. The Relationship between Body Composition and Physical Activity in Patients with Crohn's Disease.
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Maurizio Marra, Olivia Di Vincenzo, Iolanda Cioffi, Rosa Sammarco, Luca Scalfi, and Fabrizio Pasanisi
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- 2019
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18. Athletes with different habitual fluid intakes differ in hydration status but not in body water compartments
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Rúben Francisco, Filipe Jesus, Catarina L. Nunes, Iolanda Cioffi, Marta Alvim, Goncalo V. Mendonca, Henry Lukaski, Luís B. Sardinha, and Analiza M. Silva
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Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Published
- 2023
19. Comparison of bioelectrical impedance analysis–derived phase angle in individuals with different weight status
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Olivia Di Vincenzo, Maurizio Marra, Valentina Antognozzi, Rosa Sammarco, Giada Ballarin, Iolanda Cioffi, Luca Scalfi, Fabrizio Pasanisi, Di Vincenzo, Olivia, Marra, Maurizio, Antognozzi, Valentina, Sammarco, Rosa, Ballarin, Giada, Cioffi, Iolanda, Scalfi, Luca, and Pasanisi, Fabrizio
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BMI ,Phase angle ,Age ,Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Control ,Obesity ,Bioimpedance analysi ,Weight - Abstract
Objective: Obesity is characterized not only by an increase of fat mass but also by alterations in skeletal muscle. Bioimpedance analysis (BIA)-derived phase angle (PhA) may provide specific information on the inherent characteristics of fat-free mass, and is widely used as an index of poor nutritional status. The aim of this study was to describe whether and to what extent PhA varies depending on age, sex, and body mass index (BMI) in individuals with different weight status. Methods: We selected 1877 participants for this retrospective study (two weight status groups): 983 individuals with obesity (age 40 ± 13.9 y; BMI 39.5 ± 7.2 kg/m²) and 894 controls (age 40 ± 13.3 y; BMI 24.6 ± 2.7 kg/m²). Anthropometry and PhA at 50 kHz for the whole body were performed in all participants. Results: PhA was greater in men than in women, although a decline of PhA was observed with age, which was linear in women and occurred in men after 40 y of age. On the other hand, no significant differences were observed with increasing BMI in either sex; lower values might be observed when BMI >50 kg/m². Conclusions: A more detailed appraisal of BIA-derived PhA in obesity is reported in the present study, providing basic data that might be taken into consideration in prevention and clinical nutrition. Further studies are needed to explore differences of PhA in individuals with different weight status.
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- 2023
20. Bioelectrical Phase Angle in Patients with Breast Cancer: A Systematic Review
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Delia Morlino, Iolanda Cioffi, Maurizio Marra, Olivia Di Vincenzo, Luca Scalfi, Fabrizio Pasanisi, Morlino, D., Cioffi, I., Marra, M., Di Vincenzo, O., Scalfi, L., and Pasanisi, F.
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Cancer Research ,Oncology ,fat ma ,bioimpedance-analysi ,muscle strength ,chemotherapy ,survival - Abstract
Breast cancer (BC) is the most common cancer diagnosed among women worldwide. Phase angle (PhA), a proxy measure of membrane integrity and function, has gained relevance in clinical practice and it has been suggested to be a prognostic and nutritional indicator. This systematic review aimed to explore PhA and its relationship with nutritional status and survival in BC patients. Four databases (PubMed, EMBASE, Web of Science, and CINAHL) were systematically searched until September 2021 for studies evaluating PhA in BC patients. A total of 16 studies met the inclusion criteria, where 11 were observational studies and 5 were interventional studies. Baseline PhA-value varied from 4.9 to 6.30 degrees, showing a great variability and heterogeneity across the selected studies. Available data suggested that PhA decreased by 5–15% after completing chemotherapy, and those effects might persist in the long term. However, the use of tailored nutritional and/or exercise programs during and after therapy could prevent PhA reduction and body derangement. High PhA values were found in women displaying a better nutritional status, while inconsistent data were found on survival. Therefore, further studies are needed to focus on the clinical relevance of PhA in BC patients, evaluating its association with disease outcomes and survival.
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- 2022
21. New Predictive Equations for Estimating Resting Energy Expenditure in Adults With Crohn's Disease
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Nicola Imperatore, Luca Scalfi, Maria Carmen Pagano, Maurizio Marra, D. Morlino, Olivia Di Vincenzo, Iolanda Cioffi, Fabrizio Pasanisi, Lidia Santarpia, Lucia Alfonsi, Fabiana Castiglione, Marra, M, Cioffi, I, Morlino, D, Vincenzo, Od, Pagano, Mc, Imperatore, N, Alfonsi, L, Santarpia, L, Castiglione, F, Scalfi, L, and Pasanisi, F.
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Adult ,Male ,Adolescent ,Population level ,030309 nutrition & dietetics ,Population ,dietary advice ,Medicine (miscellaneous) ,Body Mass Index ,predictive equations ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,GTP-Binding Proteins ,Predictive Value of Tests ,Weight loss ,Statistics ,energy expenditure ,medicine ,Humans ,Resting energy expenditure ,education ,Aged ,Mathematics ,0303 health sciences ,Crohn's disease ,education.field_of_study ,Nutrition and Dietetics ,Original Communication ,accuracy ,Reproducibility of Results ,Calorimetry, Indirect ,Regression analysis ,Middle Aged ,Anthropometry ,medicine.disease ,Individual level ,Original Communications ,Female ,030211 gastroenterology & hepatology ,Basal Metabolism ,medicine.symptom ,Energy Metabolism - Abstract
Background Increased resting energy expenditure (REE) has been hypothesized to be a potential cause of weight loss in individuals with Crohn's disease (CD). This study aimed to develop and validate new predictive equations for estimating REE in adults with CD. Methods Adults, ages 18–65 years, with CD were recruited. Anthropometry, indirect calorimetry, and bioimpedance analysis were performed in all patients. Disease activity was assessed by Crohn's Disease Activity Index. The new predictive equations were generated using different regression models. Prediction accuracy of the new equations was assessed and compared with the most commonly used equations. Results A total of 270 CD patients (159 males, 111 females) were included and randomly assigned to the calibration (n = 180) and validation groups (n = 90). REE was directly correlated with weight and bioimpedance index, whereas the relation with both age and disease activity was inverse. The new equations were suitable for estimating REE at population level (bias: −0.2 and −0.3, respectively). Individual accuracy was good in both models (≥80%, respectively), especially in females; and similar results were shown by some of the selected equations. But, when accuracy was set within ±5%, the new equations gave the highest prediction. Conclusion The new, disease‐specific, equations for predicting REE in individuals with CD give a good prediction accuracy as far as those proposed in the literature for the general population. However, the new ones performed better at the individual level. Further studies are needed to verify the reliability and usefulness of these new equations.
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- 2020
22. Evaluation of nutritional adequacy in adult patients with Crohn’s disease: a cross-sectional study
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Anna Testa, Olivia Di Vincenzo, L. Pellegrini, Nicola Imperatore, Fabrizio Pasanisi, Maurizio Marra, Iolanda Cioffi, Franco Contaldo, Fabiana Castiglione, Lidia Santarpia, and Maria Carmen Pagano
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0301 basic medicine ,Crohn’s disease ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Cross-sectional study ,Medicine (miscellaneous) ,Nutritional Status ,Inadequate oral intake ,Inflammatory bowel disease ,03 medical and health sciences ,Eating ,Young Adult ,0302 clinical medicine ,Crohn Disease ,Internal medicine ,medicine ,Micronutrient ,Humans ,Micronutrients ,Dietary Reference Values ,Aged ,Crohn's disease ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Dietary intake ,Original Contribution ,Anthropometry ,Middle Aged ,medicine.disease ,Nutritional assessment ,Diet ,Malnutrition ,Cross-Sectional Studies ,Italy ,030211 gastroenterology & hepatology ,Female ,business ,Energy Intake - Abstract
PurposeInadequate oral intake may play an important role in the onset of malnutrition in patients with Crohn’s disease (CD). The aims of this cross-sectional study were: (1) to compare dietary intake in clinically active and quiescent CD patients, and (2) to assess patients’ nutritional adequacy relative to the dietary reference values (DRVs) for the Italian population using LARN (Livelli di Assunzione di Riferimento di Nutrienti ed energia per la popolazione italiana).MethodsPatients aged between 18 and 65 years with a diagnosis of CD were recruited.All participants underwent anthropometry and were instructed to fill in a 3-day food record. Disease activity was clinically defined using the Crohn’s disease activity index (CDAI).ResultsOverall, 117 patients, 71 males and 46 females, with a mean age of 39.6 ± 13.8 years and a mean body weight of 65.4 ± 11.8 kg, were ultimately included. Our findings showed that the amount of nutrients was similar between patients with active and quiescent disease. The mean intake of macronutrients was adequate, except for fiber, while dietary micronutrients were insufficient. Median intakes of sodium, phosphorus, and fluorine met LARN recommendations in both sexes, and the DRVs were accomplished by many patients (53/117; 104/117 and 98/117, respectively). Interestingly, dietary amounts of iron and zinc were barely acceptable in males but not in females. However, a few of the patients (ConclusionsThis study showed that the assessment of dietary intake can be crucial for optimizing dietary intervention with focused nutrition counseling, to improve nutritional status in CD patients.
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- 2020
23. Prevalence of Vitamin D deficiency and its association with disease activity in adult patients with Crohn’s disease
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Lucia Alfonsi, Fabiana Castiglione, O. Di Vincenzo, C. Pagano, Iolanda Cioffi, D. Morlino, Nicola Imperatore, Fabrizio Pasanisi, and Lidia Santarpia
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Disease activity ,medicine.medical_specialty ,Crohn's disease ,Nutrition and Dietetics ,Adult patients ,business.industry ,Endocrinology, Diabetes and Metabolism ,Internal medicine ,Medicine ,business ,medicine.disease ,Gastroenterology ,vitamin D deficiency - Published
- 2021
24. The incidence of the refeeding syndrome. A systematic review and meta-analyses of literature
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Simona Bo, Valentina Ponzo, Marianna Pellegrini, Iolanda Cioffi, Giovannino Ciccone, Fabrizio Pasanisi, Andrea Evangelista, Ezio Ghigo, Fabio Bioletto, Cioffi, I., Ponzo, V., Pellegrini, M., Evangelista, A., Bioletto, F., Ciccone, G., Pasanisi, F., Ghigo, E., and Bo, S.
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0301 basic medicine ,medicine.medical_specialty ,Consensus ,Hypophosphatemia ,Population ,030209 endocrinology & metabolism ,Refeeding syndrome ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Intensive care ,medicine ,Artificial nutritional support ,Humans ,Refeeding Syndrome ,skin and connective tissue diseases ,education ,Critically ill ,Cohort studies ,Eating disorders ,Inpatients ,education.field_of_study ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Incidence (epidemiology) ,Incidence ,Eating disorder ,medicine.disease ,Confidence interval ,Observational Studies as Topic ,Parenteral nutrition ,Practice Guidelines as Topic ,Observational study ,business ,Cohort studie ,Cohort study - Abstract
Summary Background & aims The refeeding syndrome (RFS) has been recognized as a potentially life-threatening metabolic complication of re-nutrition, but the definition widely varies and, its incidence is unknown. The aim of this systematic review and meta-analyses was to estimate the incidence of RFS in adults by considering the definition used by the authors as well as the recent criteria proposed by the American Society of Parenteral and Enteral Nutrition (ASPEN) consensus. Furthermore, the incidence of refeeding hypophosphatemia (RH) was also assessed. Methods Four databases were systematically searched until September 2020 for retrieving trials and observational studies. The incidences of RFS and RH were expressed as percentage and reported with 95% confidence intervals (CI). Results Thirty-five observational studies were included in the analysis. The risk of bias was serious in 16 studies and moderate in the remaining 19. The incidence of RFS varied from 0% to 62% across the studies. No substantial change in the originally reported incidence of RFS was found by applying the ASPEN criteria. Similarly, the incidence of RH ranged between 7% and 62%. In the subgroup analyses, inpatients from Intensive Care Units (ICUs) and those initially fed with >20 kcal/kg/day seemed to have a higher incidence of both RFS (pooled incidence = 44%; 95% CI 36%–52%) and RH (pooled incidence = 27%; 95% CI 21%–34%). However, due to the high heterogeneity of data, summary incidence measures are meaningless. Conclusion The incidence rate of both RFS and RH greatly varied according to the definition used and the population analyzed, being higher in ICU inpatients and in those with increased initial caloric supply. Therefore, a universally accepted definition for RFS, taking different clinical contexts and groups of patients into account, is still needed to better characterize the syndrome and its approach.
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- 2021
25. Impact of Refeeding Syndrome on Short- and Medium-Term All-Cause Mortality: A Systematic Review and Meta-Analysis
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Ezio Ghigo, Iolanda Cioffi, Antonella De Francesco, Valentina Ponzo, Marianna Pellegrini, Fabio Bioletto, and Simona Bo
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medicine.medical_specialty ,Time Factors ,Population ,Subgroup analysis ,030204 cardiovascular system & hematology ,Cochrane Library ,Refeeding syndrome ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Statistical significance ,medicine ,Humans ,Nutritional support team ,030212 general & internal medicine ,Mortality ,education ,Meta-analysis ,Systematic review ,education.field_of_study ,business.industry ,Mortality rate ,General Medicine ,medicine.disease ,Confidence interval ,business - Abstract
Background The refeeding syndrome has been described as a potentially life-threatening complication of renutrition. However, moving from single reports to larger population studies, the real impact of refeeding syndrome on all-cause mortality is still unknown. Methods PubMed/Medline, EMBASE, Cochrane library, and CINAHL databases were systematically searched until September 2020 for studies reporting mortality rates in patients who developed the syndrome at renutrition compared with those who did not develop it. Effect sizes were pooled through a random-effect model. Results Thirteen studies were finally considered in the meta-analysis, for a total of 3846 patients (mean age 64.5 years; 58% males). Pooled data showed a nonsignificant trend toward an increased short-term (≤1 month) mortality in patients developing the refeeding syndrome (odds ratio = 1.27, 95% confidence interval 0.93-1.72), mostly driven by studies in which renutrition was not prescribed and supervised by a nutritional support team (P = .01 at subgroup analysis) and by studies published in previous years (P = .04 at meta-regression). When examining medium-term (≤6 month) mortality, an overall statistical significance toward higher risk was observed (odds ratio = 1.54, 95% confidence interval 1.04-2.28). Conclusion This was the first meta-analysis that specifically assessed the impact of refeeding syndrome on mortality. Our results suggested a nonsignificant trend toward increased mortality in the short term but a significantly increased mortality in the medium term. The supervision/management of the refeeding process by a nutrition specialist might be a key factor for the limitation of this mortality excess.
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- 2021
26. Resting energy expenditure in elite athletes: development of new predictive equations based on anthropometric variables and bioelectrical impedance analysis derived phase angle
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Olivia Di Vincenzo, Iolanda Cioffi, D. Morlino, R. Sammarco, Luca Scalfi, Maurizio Marra, Marra, Maurizio, Di Vincenzo, Olivia, Cioffi, Iolanda, Sammarco, Rosa, Morlino, Delia, and Scalfi, Luca
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Adult ,Male ,Adolescent ,Rest ,Population ,Regression Analysi ,Young Adult ,Athlete ,Predictive equation ,Retrospective Studie ,BIA ,Statistics ,Electric Impedance ,Humans ,Resting energy expenditure ,education ,Accuracy ,Retrospective Studies ,Mathematics ,Sport ,education.field_of_study ,Nutrition and Dietetics ,Models, Statistical ,biology ,Anthropometry ,Athletes ,Phase angle ,Training level ,Regression analysis ,Calorimetry, Indirect ,Predictive equations ,biology.organism_classification ,Regression Analysis ,Energy expenditure ,Energy Metabolism ,Bioelectrical impedance analysis ,Sports ,Research Article ,Food Science ,Human - Abstract
Background An accurate estimation of athletes’ energy needs is crucial in diet planning to improve sport performance and to maintain an appropriate body composition. This study aimed to develop and validate in elite athletes new equations for estimating resting energy expenditure (REE) based on anthropometric parameters as well as bioimpedance analysis (BIA)-derived raw variables and to validate the accuracy of selected predictive equations. Methods Adult elite athletes aged 18–40 yrs were studied. Anthropometry, indirect calorimetry and BIA were performed in all subjects. The new predictive equations were generated using different regression models. The accuracy of the new equations was assessed at the group level (bias) and at the individual level (precision accuracy), and then compared with the one of five equations used in the general population or three athletes-specific formulas. Results One-hundred and twenty-six male athletes (age 26.9 ± 9.1 yrs; weight 71.3 ± 10.9 kg; BMI 22.8 ± 2.7 kg/m2) from different sport specialties were randomly assigned to the calibration (n = 75) or validation group (n = 51). REE was directly correlated with individual characteristics, except for age, and raw BIA variables. Most of the equations from the literature were reasonably accurate at the population level (bias within ±5%). The new equations showed a mean bias −0.3% (Eq. A based on anthropometric parameters) and −0.6% (Eq. B based on BIA-derived raw variables). Precision accuracy (individual predicted-measured differences within ±5%) was ~75% in six out of eight of the selected equations and even higher for Eq. A (82.4%) and Eq. B (92.2%). Conclusion In elite athletes, BIA-derived phase angle is a significant predictor of REE. The new equations have a very good prediction accuracy at both group and individual levels. The use of phase angle as predictor of REE requires further research with respect to different sport specialties, training programs and training level.
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- 2021
27. Prediction of resting energy expenditure in healthy older adults: A systematic review
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Maurizio Marra, Iolanda Cioffi, Fabrizio Pasanisi, Luca Scalfi, Cioffi, I., Marra, M., Pasanisi, F., and Scalfi, L.
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0301 basic medicine ,Aging ,Resting metabolic rate ,Population ,Energy requirement ,030209 endocrinology & metabolism ,Indirect calorimetry ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Overnutrition ,Predictive Value of Tests ,Reference Values ,Statistics ,Humans ,Medicine ,Resting energy expenditure ,education ,Geriatric Assessment ,Group level ,Aged ,education.field_of_study ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Reproducibility of Results ,Calorimetry, Indirect ,Healthy elderly ,Individual level ,medicine.disease ,Basal metabolic rate ,Basal Metabolism ,business - Abstract
Summary Background & aims Estimates of energy requirements, based on measured or predicted resting energy expenditure (REE), are needed to avoid undernutrition or overnutrition (and their clinical consequences) in elderly subjects. The aims of this systematic review were to evaluate the prediction accuracy of REE in healthy elderly subjects and to ascertain which equation is more reliable at group level and/or individual level. Methods Studies assessing prediction of REE in general elderly population were systematically searched using PubMed, EMBASE, Web of Science and CINAHL until March 2020. Prediction accuracy of REE was assessed at both group (bias) and individual (precision) level for each equation. Results Fourteen studies met the inclusion criteria of this systematic review. Bias was reported in 8 papers and calculated in another 5 from absolute values. There was a prevalent tendency towards an overestimation of REE across the studies. The least bias was observed for the Mifflin (−0.3%) and Harris–Benedict (+2.6%) equations, with values above 5% for the FAO/WHO/UNU, Fredrix and Muller equations. Precision widely varied between studies for the same equation. The higher precision was observed using the Harris–Benedict equation (~70%), while the Henry and Mifflin equations provided estimates within 10% of measured values in 65% and 61% of elderly individuals, respectively. Conclusions None of the prediction equations considered provides accurate and precise REE estimates in healthy older adults. However, the best prediction is given by the Mifflin equation at group level and by the Harris–Benedict equation at individual level. Further studies with strong quality design are needed to evaluate the variability and accuracy of REE in the elderly general population.
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- 2021
28. A proposal for reference values of hand grip strength in women with different body mass indexes
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Fabrizio Pasanisi, D. Morlino, Emilia De Filippo, Carmela De Caprio, Olivia Di Vincenzo, R. Sammarco, Iolanda Cioffi, Maurizio Marra, E. Speranza, Morlino, D., Marra, M., Cioffi, I., Sammarco, R., Speranza, E., Di Vincenzo, O., De Caprio, C., De Filippo, E., and Pasanisi, F.
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0301 basic medicine ,Adult ,Adolescent ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Body weight ,Handgrip strength ,Body Mass Index ,BMI ,03 medical and health sciences ,Grip strength ,Young Adult ,0302 clinical medicine ,Age groups ,Reference Values ,Bayesian multivariate linear regression ,Medicine ,Humans ,Women ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Hand Strength ,business.industry ,Anthropometry ,Middle Aged ,Phase angle ,Cross-Sectional Studies ,Italy ,Bioimpedance Analysis ,Reference values ,Female ,Bioimpedance analysi ,business ,Body mass index ,Demography - Abstract
Objective Hand grip strength (HGS) is frequently used in clinical practice, resulting in a potential marker of nutritional status. This study aimed to develop reference values of HGS in Italian women with different categories of body mass index (BMI). Additionally, the main predictors of HGS were identified. Methods A cross-sectional study was conducted in Italian women between ages 16 and 55 y with different categories of BMI at the Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples Italy. The whole sample was divided into tertiles according to BMI: 15 to 17.29 kg/m2 (T1), 17.3 to 19.9 kg/m2 (T2), and 20 to 25 kg/m2 (T3). Anthropometry, bioimpedance analysis, and muscle strength by an HGS test were evaluated. The cut-off values for HGS were developed for all participants and stratified by age group. Finally, a multivariate linear regression analysis was performed to assess the main predictors of HGS. Results A total of 529 women with a mean age of 23.2 ± 7.0 y and an average BMI of 18.9 ± 2.5 kg/m2 were analyzed. HGS was higher for the dominant hand than for the non-dominant hand in all BMI tertiles. On both sides, according to age groups, HGS increased with increasing age in T1 and T3, whereas it increased in the women between ages 20 and 30 y in T2 only. Multivariate linear regression analysis showed that predictors of HGS varied according to tertiles. Specifically, we found that body weight (R2 = 0.252) was the main predictor in T1, whereas phase angle (PhA) was the main determinant in both T2 (R2 = 0.240) and T3 (R2 = 0.216). Conclusion This study defined the normal reference values of HGS in Italian women with different BMI ranges, stratifying the sample group by age. Additionally, the main predictors of HGS were assessed for each BMI tertile. In primary malnutrition (T1), the main predictor of HGS was body weight, whereas in the other two tertiles (T2, T3), the PhA was the main predictor of HGS.
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- 2020
29. The Refeeding Syndrome: a neglected but potentially serious condition for inpatients. A narrative review
- Author
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Valentina Ponzo, Marianna Pellegrini, Simona Bo, Luca Scaglione, and Iolanda Cioffi
- Subjects
medicine.medical_specialty ,Critical Care ,030309 nutrition & dietetics ,Hypophosphatemia ,Hypokalemia ,Hypomagnesemia ,Malnutrition ,Refeeding syndrome ,Thiamine ,Fluid shift ,Risk Assessment ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Standard definition ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Intensive care medicine ,Monitoring, Physiologic ,0303 health sciences ,Inpatients ,business.industry ,Nutritional Support ,Incidence (epidemiology) ,medicine.disease ,Im - Review ,Parenteral nutrition ,Emergency Medicine ,Narrative review ,business - Abstract
The Refeeding Syndrome (RFS) is a potentially serious, but still overlooked condition, occurring in individuals who are rapidly fed after a period of severe undernourishment. RFS derives from an abnormal electrolyte and fluid shifts leading to many organ dysfunctions. Symptoms generally appear within 2–5 days of re-feeding and may be absent/mild or severe and life threating, depending on the pre-existing degree of malnutrition and comorbidities. The lack of a standard definition and the nonspecificity of the symptoms make both incidence estimate and diagnosis difficult. In 2020, the American Society for Parenteral and Enteral Nutrition (ASPEN) proposed a unifying definition for the RFS and its severity classification. The awareness of the condition is crucial for identifying patients at risk, preventing its occurrence, and improving the management. The objectives of this narrative review were to summarize the current knowledge and recommendations about the RFS and to provide useful tips to help physicians to recognize and prevent the syndrome. Electronic supplementary material The online version of this article (10.1007/s11739-020-02525-7) contains supplementary material, which is available to authorized users.
- Published
- 2020
30. Body composition, segmental bioimpedance phase angle and muscular strength in professional volleyball players compared to a control group
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Luca Scalfi, Iolanda Cioffi, E. Speranza, Olivia Di Vincenzo, Maurizio Marra, R. Sammarco, DI VINCENZO, Olivia, Marra, Maurizio, Sammarco, Rosa, Speranza, Enza, Cioffi, Iolanda, and Scalfi, Luca
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Physical Therapy, Sports Therapy and Rehabilitation ,Athletic Performance ,Physical strength ,Young Adult ,03 medical and health sciences ,Grip strength ,0302 clinical medicine ,Hand strength ,medicine ,Humans ,Orthopedics and Sports Medicine ,030109 nutrition & dietetics ,Hand Strength ,business.industry ,Phase angle ,Nutritional status ,030229 sport sciences ,Hand ,Control Groups ,Skinfold Thickness ,Volleyball ,Skinfold thickness ,Athletes ,Body Composition ,Physical therapy ,Female ,business ,human activities ,Bioelectrical impedance analysis - Abstract
Background: The assessment of body composition is central in evaluating athletes' nutritional status and the effects of training. The aim of this study was to evaluate body composition and the relation between bioimpedance phase angle (PhA) and muscular strength in elite female volleyball players. Methods: Twelve volleyball players (age 23.8±3.6 years; weight 63.0±5.1 kg; height 170±4 cm; BMI 21.9±1.3 kg/m2) and 22 non-athletic females, who served as a control group (age 23.6±2.0 years; weight 60.7±4.8 kg; height 167±5 cm; BMI 21.9±1.3 kg/m2), participating in the study. Skinfold thickness measures were used and segmental bioelectrical impedance analysis (BIA) was performed. Additionally, hand grip strength was used to evaluate muscular strength. Results: Volleyball players had lower FM and higher FFM than controls (FM(kg)=15.7±2.7 vs. 18.0±3.0, P=0.036; FM(%)=24.8±3.0 vs. 29.5±3.8, P=0.001; FFM(kg)=47.4±3.5 vs. 42.8±3.6, P=0.001). Both whole-body and segmental PhA were higher in volleyball players (P
- Published
- 2020
31. Association between Health-Related Quality of Life and Nutritional Status in Adult Patients with Crohn’s Disease
- Author
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Franco Contaldo, Nicola Imperatore, Olivia Di Vincenzo, Lidia Santarpia, Fabiana Castiglione, Anna Testa, Fabrizio Pasanisi, Maurizio Marra, Antonio Rispo, Iolanda Cioffi, Cioffi, I., Imperatore, N., Di Vincenzo, O., Santarpia, L., Rispo, A., Marra, M., Testa, A., Contaldo, F., Castiglione, F., and Pasanisi, F.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Inflammatory bowel disease ,Muscle strength ,Nutritional assessment ,Quality of life ,Nutritional Status ,lcsh:TX341-641 ,Disease ,Severity of Illness Index ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,Risk Factors ,inflammatory bowel disease ,Internal medicine ,medicine ,Humans ,Body Weights and Measures ,Public Health Surveillance ,030212 general & internal medicine ,Settore MED/49 - Scienze Tecniche Dietetiche Applicate ,Health related quality of life ,Crohn's disease ,Nutrition and Dietetics ,Adult patients ,business.industry ,Nutritional status ,Middle Aged ,Anthropometry ,medicine.disease ,digestive system diseases ,humanities ,Cross-Sectional Studies ,Nutrition Assessment ,quality of life ,nutritional assessment ,muscle strength ,Female ,030211 gastroenterology & hepatology ,business ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
This study aimed to assess health related quality of life (HRQoL) in adult patients with Crohn&rsquo, s disease (CD), considering disease severity and gender differences, and also its relationship with nutritional status. Consecutive adult patients aged 18&ndash, 65 years with CD were recruited. Disease activity was clinically defined by the Crohn&rsquo, s Disease Activity Index (CDAI) in active and quiescent phases. HRQoL was evaluated using the validated short form (SF)-36 questionnaire for the Italian population. Additionally, anthropometry, bioimpedance analysis, and handgrip-strength (HGS) were performed. Findings showed that 135 patients (79 men and 56 women) were included, having a mean age of 38.8 ±, 14 years and a BMI of 23.2 ±, 3.7 kg/m2. Overall, active CD patients had a lower perception of their QoL compared to those clinically quiescent, while gender differences emerged mostly in the quiescent group. Interestingly, HRQoL was significantly associated with many nutritional variables, and muscle strength was the main predictor. Therefore, HRQoL is perceived lower in active compared to quiescent patients, but women experienced poorer QoL than men, especially in the quiescent phase. Finally, higher QoL scores were found in subjects being in clinical remission phase with a preserved muscle function. However, further studies are still required to verify these findings.
- Published
- 2020
32. Macronutrients in Parenteral Nutrition: Amino Acids
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Lidia Santarpia, C. Scanzano, Iolanda Cioffi, Franco Contaldo, Fabrizio Pasanisi, Roberto Iacone, Iacone, R., Scanzano, C., Santarpia, L., Cioffi, I., Contaldo, F., and Pasanisi, F.
- Subjects
0301 basic medicine ,medicine.medical_specialty ,030209 endocrinology & metabolism ,parenteral nutrition ,lcsh:TX341-641 ,Review ,nitrogen balance ,Muscle mass ,Energy requirement ,03 medical and health sciences ,Patient type ,0302 clinical medicine ,amino acid requirement ,Amino acid ,Amino acid requirement ,Essential amino acid ,Nitrogen balance ,Parenteral nutrition ,medicine ,Humans ,Settore MED/49 - Scienze Tecniche Dietetiche Applicate ,Amino Acids ,Intensive care medicine ,essential amino acid ,chemistry.chemical_classification ,Parenteral Nutrition Solutions ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,energy requirement ,Nutritional Requirements ,Nutrients ,chemistry ,Narrative review ,Parenteral Nutrition, Total ,business ,lcsh:Nutrition. Foods and food supply ,amino acid ,Food Science - Abstract
The right amount and quality of amino acids (AAs) supplied to patients on parenteral nutrition (PN) reduces muscle mass loss, may preserve or even increase it, with significant clinical benefits. Several industrial PN mixtures are available so that nutrition specialists can choose the product closest to the patient’s needs. In selected cases, there is the possibility of personalizing compounded mixtures in a hospital pharmacy that completely meets the individual nutritional needs of PN patients. This narrative review deals with the AA solutions used in PN mixtures. The physiology, the methods to calculate the AA needs, and the AA and energy requirements suggested by scientific guidelines for each patient type are also reported.
- Published
- 2020
33. Assessment of bioelectrical phase angle as a predictor of nutritional status in patients with Crohn's disease: A cross sectional study
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Fabiana Castiglione, Nicola Imperatore, Anna Testa, R. Sammarco, Maurizio Marra, Franco Contaldo, Lidia Santarpia, Lucia Alfonsi, Fabrizio Pasanisi, Maria Carmen Pagano, Iolanda Cioffi, Cioffi, I., Marra, M., Imperatore, N., Pagano, M. C., Santarpia, L., Alfonsi, L., Testa, A., Sammarco, R., Contaldo, F., Castiglione, F., and Pasanisi, F.
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Cross-sectional study ,030209 endocrinology & metabolism ,Disease ,Critical Care and Intensive Care Medicine ,Gastroenterology ,Inflammatory bowel disease ,Body composition ,Handgrip strength ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,Nutritional status ,Internal medicine ,Electric Impedance ,medicine ,Humans ,Crohn's disease ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Anthropometry ,business.industry ,Phase angle ,Middle Aged ,medicine.disease ,Malnutrition ,Cross-Sectional Studies ,Nutrition Assessment ,Case-Control Studies ,Female ,Bioimpedance analysi ,business ,Biomarkers - Abstract
The assessment of body composition (BC) can be used to identify malnutrition in patients with Crohn's disease (CD). The aim of this study was to evaluate the nutritional status of CD patients by assessing BC, phase angle (PhA) and muscle strength. Differences in disease duration and medications were also considered.Consecutive adult CD patients aged 18-65 years were enrolled in this cross-sectional study. Disease activity was clinically defined by the Crohn's Disease Activity Index (CDAI) in the active and quiescent phases. All participants underwent anthropometry, BC and handgrip-strength (HGS) measurements; additionally, blood samples were taken. Data from CD patients were also compared with age-, sex- and BMI-matched healthy people.A total of 140 CD patients with a mean age of 38.8 ± 13.9 years and a mean body weight of 64.9 ± 12 kg were recruited and compared to controls. The findings showed that all nutritional parameters, especially PhA and HGS, were lower in CD patients than in controls, and these parameters were substantially impaired as disease activity increased. Active CD patients had a lower body weight and fat mass than both the quiescent and control groups. PhA was negatively correlated with age (r = -0.362; p = 0.000) and CDAI (r = -0.135; p = 0.001) but was positively associated with fat free mass (FFM) (r = 0.443; p = 0.000) and HGS (r = 0.539; p = 0.000). Similarly, serum protein markers were lower in the active CD group than in the quiescent group (p 0.05). Disease duration and medications did not significantly affect nutritional status.BIA-derived PhA is a valid indicator of nutritional status in CD patients, and its values decreased with increasing disease activity. Additionally, small alterations in BC, such as low FFM, and reduced HGS values can be considered markers of nutritional deficiency. Therefore, the assessment of BC should be recommended in clinical practice for screening and monitoring the nutritional status of CD patients.
- Published
- 2020
34. Relationship between Handgrip Strength, Anthropometric and Body Composition Variables in Different Athletes
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E. Speranza, Iolanda Cioffi, R. Sammarco, Maurizio Marra, Luca Scalfi, Olivia Di Vincenzo, and D. Morlino
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Athletes ,Physical therapy ,Medicine ,Anthropometry ,business ,biology.organism_classification - Published
- 2020
35. Resting Energy Expenditure in Elite Female Athletes of Different Sports
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D. Morlino, Olivia Di Vincenzo, R. Sammarco, Iolanda Cioffi, Maurizio Marra, Luca Scalfi, and E. Speranza
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medicine.medical_specialty ,biology ,Athletes ,business.industry ,Elite ,Physical therapy ,medicine ,Resting energy expenditure ,biology.organism_classification ,business - Published
- 2020
36. Acute assessment of subjective appetite and implicated hormones after a hypnosis-induced hallucinated meal: a randomized cross-over pilot trial
- Author
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Fabrizio Pasanisi, Rosalba Rosato, Simona Bo, Roberto Gambino, Giuseppe Regaldo, Bice Properzi, Valentina Ponzo, Franco Contaldo, Ezio Ghigo, Marianna Pellegrini, Iolanda Cioffi, Cioffi, I., Gambino, R., Rosato, R., Properzi, B., Regaldo, G., Ponzo, V., Pellegrini, M., Contaldo, F., Pasanisi, F., Ghigo, E., and Bo, S.
- Subjects
Blood Glucose ,Leptin ,medicine.medical_specialty ,Hallucinations ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Appetite ,030209 endocrinology & metabolism ,Pilot Projects ,Hypnosis ,Obesity ,Orexin, Neuropeptide-Y ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Glucagon-Like Peptide 1 ,Internal medicine ,Medicine ,Humans ,Insulin ,Peptide YY ,Meals ,media_common ,Breakfast ,Meal ,Orexins ,Cross-Over Studies ,business.industry ,Hypnosi ,digestive, oral, and skin physiology ,Repeated measures design ,Neuropeptide-Y ,Middle Aged ,Postprandial Period ,Crossover study ,Ghrelin ,Hormones ,Postprandial ,Italy ,Hallucinating ,alpha-MSH ,Orexin ,Female ,Sample collection ,business - Abstract
The use of hypnosis can generate hallucinatory phenomena, which ranged from vivid/auditory imagery to fully developed “hallucinations” in selected people. The aim of this pilot trial was investigating the acute effects of a hypnosis-induced hallucinated breakfast (HB) compared to those of a real breakfast (RB) on subjective appetite and appetite-regulating hormones in highly hypnotizable individuals. Eight healthy post-menopausal women were recruited to consume two meals: the HB and the RB in a randomized crossover design. Participants underwent appetite sensations measurements (before meal and each 30-min until 270-min) and blood sample collection (at 0, 20, 60, 90, 180-min). A 3-day food-record was filled after each meal. The adjusted repeated measures ANCOVA did not show any meal×time interactions on subjective appetite postprandially. As expected, significantly higher glucose (p < 0.001), insulin (p < 0.001), and lower free fatty acid (p < 0.001) concentrations were found after the RB, but not following HB. Furthermore, RB significantly increased postprandial levels of glucagon-like-peptide-1 and peptide-YY at 20, 60, 90 and 180-min, whereas acylated-ghrelin and leptin levels did not differ. Postprandial neuropeptide-Y and orexin-A values significantly increased at different time-points after RB, but not following HB, while α-melanocyte-stimulating hormone levels enhanced after HB only. Energy intakes were significantly lower after HB on the test-day only (HB = 1146.6 ± 343.8 vs RB = 1634.7 ± 274.2 kcal/d; p = 0.003). Appetite sensation might be modulated by fully developed meal “hallucination” induced by hypnosis, likely affecting brain-peptides implicated in the appetite regulation. However, further studies are needed to verify these results obtained in a highly selected group of individuals. NCT03934580.
- Published
- 2020
37. Assessment of serum amino acids profile in adult patients with Crohn’s disease
- Author
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Fabiana Castiglione, Lidia Santarpia, D. Morlino, M. Caterino, Fabrizio Pasanisi, M. Fisco, M. Ruoppolo, O. Di Vincenzo, Nicola Imperatore, and Iolanda Cioffi
- Subjects
medicine.medical_specialty ,Crohn's disease ,Nutrition and Dietetics ,Adult patients ,Serum amino acids ,business.industry ,Endocrinology, Diabetes and Metabolism ,Internal medicine ,Medicine ,business ,medicine.disease ,Gastroenterology - Published
- 2021
38. LONG TERM NUTRITIONAL AND METABOLIC COMPLICATIONS AFTER MALABSORPTIVE BARIATRIC SURGERY
- Author
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D. Morlino, Lidia Santarpia, C. Bongiorno, Iolanda Cioffi, Fabrizio Pasanisi, Maurizio Marra, E. Speranza, M.L. Santopaolo, and Lucia Alfonsi
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,medicine.disease ,Surgery ,Osteopenia ,Malnutrition ,Parenteral nutrition ,Weight loss ,Sarcopenia ,medicine ,In patient ,medicine.symptom ,Densitometry ,business - Abstract
Objective Bariatric surgery is the most effective treatment for weight reducing and weight loss maintaining in patients with severe obesity. Malabsorptive interventions, in particular, may be responsible of severe long term complications. Methods and procedures Twenty-one patients (9 M, 12 F; 50,8 ± 10,3 years) already followed up at the outpatient unit for secondary malnutrition were evaluated. Results The time from surgery was 14,6 ± 6,64 years (min 3 – max 25). Seven patients (2 M, 5 F) received Roux-en-Y Gastric Bypass (GBP) and 14 (5 M, 7 F) Bilio-pancreatic diversion (BPD). Eight patients received oral nutritional supplements (2 GBP - 6 BPD) and 6 (1 GBP – 5 BPD) intravenous hydroelectrolitic supplementation up to parenteral nutrition. Bone densitometry (Dual energy X ray absorpimetry, DXA) on lumbar spine and left femur neck showed osteoporosis in 8 patients (38%), osteopenia in 9 (43%) and normal bone mineral densitometry in 4 patients (19%). Body composition was measured by bioimpedenziometry (BIA). According to the criteria of the European Working Group on Sarcopenia 2010, seven (33%) patients had severe sarcopenia, 12 (57%) moderate sarcopenia and 2 (10%) normal body composition Conclusion The obtained results highlight high rates of bone and muscle mass depletion in these patients, despite they were already followed up and supplemented. An accurate pre-surgical evaluation to unmask and correct possible nutritional deficiencies and a regular post-surgery follow up are recommended, in order to prevent possible long term complications of bariatric malabsorptive procedure.
- Published
- 2021
39. Prediction and evaluation of resting energy expenditure in a large group of obese outpatients
- Author
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M. Naccarato, Maurizio Marra, V. Amato, Franco Contaldo, Fabrizio Pasanisi, Concetta Montagnese, R. Sammarco, Iolanda Cioffi, Marra, Maurizio, Cioffi, Iolanda, Sammarco, Rosa, Montagnese, Concetta, Naccarato, M, Amato, Valeria, Contaldo, Franco, and Pasanisi, Fabrizio
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Rest ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,White People ,Body Mass Index ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,Outpatients ,Statistics ,medicine ,Humans ,Resting energy expenditure ,Obesity ,Mathematics ,Analysis of Variance ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Reproducibility of Results ,Calorimetry, Indirect ,Middle Aged ,Models, Theoretical ,medicine.disease ,Endocrinology ,Standard error ,Italy ,Predictive value of tests ,Basal metabolic rate ,Original Article ,Female ,Basal Metabolism ,Analysis of variance ,medicine.symptom ,Body mass index ,Weight gain - Abstract
Background/Objectives: The aim of this study was to compare resting energy expenditure (REE) measured (MREE) by indirect calorimetry (IC) and REE predicted (PREE) from established predictive equations in a large sample of obese Caucasian adults. Subjects/Methods: We evaluated 1851 obese patients (body mass index (BMI)>30 kg m−2) aged between 18a and 65 years. Data were obtained by comparing MREE with PREE, derived from different equations, within and between normal weight and obese groups. The mean differences between PREE and MREE as well as the accuracy prediction within ±10% level were investigated in the whole sample and in three subgroups, classified by BMI (Group 1=30–39.9 kg m−2; Group 2=40–49.9 kg m−2; Group 3>50 kg m−2). Results: We observed that FAO, Henry and Muller3 (body composition (BC)) equations provided good mean PREE–MREE (bias −0.7, −0.3 and 0.9% root mean standard error (RMSE) 273, 263 and 269 kcal per day, respectively); HB and Henry equations were more accurate individually (57 and 56.9%). Only the Muller1 (BC) equation gave the lowest PREE–MREE difference (bias −1.7% RMSE 228 kcal per day) in females, while Johnstone and De Lorenzo equations were the most accurate (55.1 and 54.8%). When the sample was split into three subgroups according to BMI, no differences were found in males; however, the majority of the equations included in this study failed to estimate REE in severely obese females (BMI>40 kg m−2). Overall, prediction accuracy was low (~55%) for all predictive equations, regardless of BMI. Conclusions: Different established equations can be used for estimating REE at the population level in both sexes. However, the accuracy was very low for all predictive equations used, particularly among females and when BMI was high, limiting their use in clinical practice. Our findings suggest that the validation of new predictive equations would improve the accuracy of REE prediction, especially for severely obese subjects (BMI>40 kg m−2).
- Published
- 2017
40. Impaired Enterohormone Response Following a Liquid Test Meal in Gastrectomized Patients
- Author
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Lidia Santarpia, Fabrizio Pasanisi, Maria Carmen Pagano, Lucia Sacchetti, Iolanda Cioffi, Lucia Alfonsi, Giuseppe Labruna, Rosario Cuomo, Franco Contaldo, Santarpia, Lidia, Pagano, Maria Carmen, Cioffi, Iolanda, Alfonsi, Lucia, Cuomo, Rosario, Labruna, Giuseppe, Sacchetti, Lucia, Contaldo, Franco, and Pasanisi, Fabrizio
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Gastroenterology ,03 medical and health sciences ,Liquid meal test ,0302 clinical medicine ,Gastrectomy ,Glucagon-Like Peptide 1 ,Weight loss ,Internal medicine ,Entero-hormone ,medicine ,Humans ,Insulin ,Meals ,Cholecystokinin ,Meal ,Nutrition and Dietetics ,business.industry ,Weight change ,digestive, oral, and skin physiology ,Middle Aged ,medicine.disease ,Malnutrition ,Total gastrectomy ,Case-Control Studies ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Hormone - Abstract
Background: Total gastrectomy (TG) is responsible for symptoms or disturbance of alimentary status (changes in body weight, food intake per meal and frequency of meal per day) which, in turn are responsible for weight loss and malnutrition. The study evaluates the gut hormone responses in totally gastrectomized (TG) patients after a liquid meal test. Methods: Twenty total gastrectomized cancer-free patients (12 M, 8 F, 56.4 ± 10.2 years, BMI 21.4 ± 2.2 kg/m2) and 10 healthy volunteers (4 M, 6 F, 48.0 ± 12.7 years, BMI 26.7 ± 3.0 kg/m2 ) drank a liquid meal (1.25 kcal/mL) at the rate of 50 mL/5′ min for a maximum of 30 min. Satiety score was assessed and blood sample was taken at different time points. Results: The time response course, particularly for insulin, glucose-like pepetide-1, and cholecystokinin, significantly differed between TG patients and controls. Conclusions: Our results may help to better understand hormone responses triggered by the faster arrival of nutrients in the small bowel and to explain some post-TG symptoms.
- Published
- 2017
41. Incidence of diabetes mellitus, cardiovascular outcomes and mortality after a 12-month lifestyle intervention: A 9-year follow-up
- Author
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L. Gentile, Roberto Gambino, Iolanda Cioffi, Simona Bo, Andrea Benso, Rosalba Rosato, N Pellegrini, Ponzo, Maurizio Cassader, and Fabio Broglio
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Randomized controlled trial ,law ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Life Style ,Survival rate ,Aged ,biology ,Diabetes and Metabolism ,business.industry ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,C-reactive protein ,Type 2 Diabetes Mellitus ,General Medicine ,Middle Aged ,medicine.disease ,Survival Rate ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Number needed to treat ,biology.protein ,Female ,business ,Follow-Up Studies - Published
- 2018
42. Are Raw BIA Variables Useful for Predicting Resting Energy Expenditure in Adults with Obesity?
- Author
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Fabrizio Pasanisi, Maurizio Marra, Luca Scalfi, R. Sammarco, Lidia Santarpia, Franco Contaldo, Iolanda Cioffi, Marra, Maurizio, Cioffi, Iolanda, Sammarco, Rosa, Santarpia, Lidia, Contaldo, Franco, Scalfi, Luca, and Pasanisi, Fabrizio
- Subjects
0301 basic medicine ,Adult ,Male ,obesity ,Calibration (statistics) ,030209 endocrinology & metabolism ,lcsh:TX341-641 ,Article ,Correlation ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Statistics ,medicine ,Electric Impedance ,Humans ,Resting energy expenditure ,Mathematics ,Retrospective Studies ,body composition ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Phase angle ,Anthropometry ,Middle Aged ,medicine.disease ,Obesity ,phase angle ,Basal metabolic rate ,basal metabolic rate ,Female ,Basal Metabolism ,Energy Metabolism ,Body mass index ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
This study aimed to develop and validate new predictive equations for resting energy expenditure (REE) in a large sample of subjects with obesity also considering raw variables from bioimpedance-analysis (BIA). A total of 2225 consecutive obese outpatients were recruited and randomly assigned to calibration (n = 1680) and validation (n = 545) groups. Subjects were also split into three subgroups according to their body mass index (BMI). The new predictive equations were generated using two models: Model 1 with age, weight, height, and BMI as predictors, and Model 2 in which raw BIA variables (bioimpedance-index and phase angle) were added. Our results showed that REE was directly correlated with all anthropometric and raw-BIA variables, while the correlation with age was inverse. All the new predictive equations were effective in estimating REE in both sexes and in the different BMI subgroups. Accuracy at the individual level was high for specific group-equation especially in subjects with BMI >, 50 kg/m2. Therefore, new equations based on raw-BIA variables were as accurate as those based on anthropometry. Equations developed for BMI categories did not substantially improve REE prediction, except for subjects with a BMI >, 50 kg/m2. Further studies are required to verify the application of those formulas and the role of raw-BIA variables for predicting REE.
- Published
- 2019
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43. The Relationship between Body Composition and Physical Activity in Patients with Crohn’s Disease
- Author
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Olivia Di Vincenzo, Iolanda Cioffi, Maurizio Marra, R. Sammarco, Luca Scalfi, and Fabrizio Pasanisi
- Subjects
medicine.medical_specialty ,Crohn's disease ,business.industry ,Physical activity ,Adipose tissue ,Anthropometry ,Control subjects ,Physical strength ,medicine.disease ,Endocrinology ,Internal medicine ,Medicine ,Composition (visual arts) ,In patient ,business - Abstract
Crohn’s disease (CD) is a chronic inflammatory gastrointestinal disease associated with malnutrition, inadequate intake, increased energy expenditure, impaired digestion and absorption, leading to a reduction in skeletal muscle mass and adipose tissue. The purpose of this study was to evaluate body composition, phase angle (PhA) and muscular strength in a group of patients with CD. Forty-six male patients, participated in the study and were divided into two groups: 10 physically active patients (A-, age 29.1±8.9 years; weight 68.5±7.2 kg; height 172±4 cm; BMI 23.2±2.7 kg/m2) and 36 sedentary (S-, age 28.9±7.4 years; weight 67.7±8.6 kg; height 174±6 cm; BMI 22.4±2.5 kg/m2). Additionally, 20 healthy control subjects (CONTR, age 30.8±9.2 years; weight 71.4±5.6 kg; height 176±5 cm; BMI 23.1±2.1 kg/m2) participated in the study. S- presented significantly lower FFM values compared to control subjects (p
- Published
- 2019
44. Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis
- Author
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Andrea Evangelista, Simona Bo, Valentina Ponzo, Ezio Ghigo, Marianna Pellegrini, Giovannino Ciccone, Iolanda Cioffi, and Ilaria Goitre
- Subjects
Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Weight loss ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Subgroup analysis ,Management of obesity ,law.invention ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Endocrinology ,Randomized controlled trial ,law ,Diabetes mellitus ,Internal medicine ,Time restricted feeding ,medicine ,Humans ,Obesity ,Observational studies ,Aged ,Randomized Controlled Trials as Topic ,Meal ,Fasting glucose ,Nutrition and Dietetics ,business.industry ,Body Weight ,Fasting ,Middle Aged ,medicine.disease ,Confidence interval ,Randomized controlled trials ,Observational Studies as Topic ,Regimen ,Meta-analysis ,Female ,Observational study ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Restriction in meal timing has emerged as a promising dietary approach for the management of obesity and dysmetabolic diseases. The present systematic review and meta-analysis summarized the most recent evidence on the effect of time-restricted feeding (TRF) on weight-loss and cardiometabolic variables in comparison with unrestricted-time regimens. Studies involving TRF regimen were systematically searched up to January 2019. Effect size was expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). A total of 11 studies, 5 randomized controlled trials and 6 observational, were included. All selected studies had a control group without time restriction; hours of fasting ranged from 12-h until 20-h and study duration from 4 to 8-weeks. Most studies involved the Ramadan fasting. TRF determined a greater weight-loss than control regimens (11 studies, n = 485 subjects) (WMD: −1.07 kg, 95%CI: −1.74 to −0.40; p = 0.002; I2 = 56.2%), unrelated to study design. The subgroup analysis showed an inverse association between TRF and fat free mass in observational studies (WMD: −1.33 kg, 95%CI: −2.55 to −0.11; p = 0.03; I2 = 0%). An overall significant reduction in fasting glucose concentrations was observed with TRF regimens (7 studies, n = 363 subjects) (WMD: −1.71 mg/dL, 95%CI: −3.20 to −0.21; p = 0.03; I2 = 0%), above all in trials (WMD:-2.45 mg/dL, 95%CI: −4.72 to −0.17; p = 0.03; I2 = 0%). No between-group differences in the other variables were found. TRF regimens achieved a superior effect in promoting weight-loss and reducing fasting glucose compared to approaches with unrestricted time in meal consumption. However, long-term and well-designed trials are needed to draw definitive conclusions.
- Published
- 2019
45. RUOLO DEL DIGIUNO E DELLA RESTRIZIONE CALORICA NELLA TERAPIA DEL DIABETE TIPO 2
- Author
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Simona Bo Prof, Iolanda Cioffi Prof., and Valentina Ponzo Prof.
- Subjects
business.industry ,Medicine ,business - Abstract
L’incremento epidemico del diabete mellito di tipo 2 (DMT2) è strettamente correlato con l’aumento dell’obesità a livello mondiale (1). È noto che una riduzione modesta del peso corporeo compresa tra il 5% ed il 10% può migliorare il compenso glicemico o prevenire l’insorgenza del DMT2 (2-3). L’intervento dietetico è universalmente considerato il caposaldo nella prevenzione, gestione e trattamento della patologia e delle complicanze ad esso associate (4). Attualmente c’è un crescente interesse verso i regimi dietetici basati sull’intermittenza di digiuno o di restrizioni caloriche estreme (5-6). Tuttavia, vi è anche una certa confusione in merito alla definizione di restrizione energetica intermittente. È ipotizzabile che alcune delle modificazioni che si verificano durante il digiuno protratto possano essere benefiche per i pazienti affetti da DMT2 (per es. la riduzione dell’insulino-resistenza, l’aumento della lipolisi, l’utilizzo preferenziale dei corpi chetonici a livello cerebrale, la conseguente riduzione della neoglucogenesi, la perdita di massa grassa), ma non è chiaro in quale misura questi meccanismi operino realmente negli attuali regimi di digiuno studiati. Complessivamente, nei soggetti sani, l’effetto di restrizioni caloriche intermittenti sul peso corporeo e sul profilo cardio-metabolico sembra essere comparabile alla restrizione calorica continua. I dati sui pazienti affetti da DMT2 sono ad oggi pochi e spesso contrastanti (7-8). In questa rassegna, analizzeremo le evidenze ad oggi presenti in letteratura sull’effetto del digiuno e/o delle restrizioni caloriche intermittenti per la prevenzione ed il trattamento del DMT2.
- Published
- 2018
46. New predictive equations for estimating resting energy expenditure in subjects with normal weight and overweight
- Author
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Fabrizio Pasanisi, Maurizio Marra, E. Speranza, R. Sammarco, Iolanda Cioffi, D. Morlino, Olivia Di Vincenzo, Marra, M., Sammarco, R., Cioffi, I., Morlino, D., Di Vincenzo, O., Speranza, E., and Pasanisi, F.
- Subjects
Adult ,Male ,0301 basic medicine ,Calibration and validation ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Indirect calorimetry ,Overweight ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Predictive equation ,Predictive Value of Tests ,Statistics ,medicine ,Humans ,Resting energy expenditure ,Obesity ,Normal weight ,Group level ,Mathematics ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Phase angle ,Reproducibility of Results ,Calorimetry, Indirect ,Bioimpedance Analysis ,Female ,Basal Metabolism ,Bioimpedance analysi ,medicine.symptom ,Energy Metabolism ,Body mass index - Abstract
Objective: The aim of this study was to develop and validate new predictive equations for estimating resting energy expenditure (REE) in subjects with normal weight and overweight, considering anthropometric parameters as well as raw variables from bioimpedance analysis (BIA). Methods: Adult participants with normal weight and overweight were recruited and randomly split into calibration and validation groups. Indirect calorimetry (IC) and BIA were performed in all subjects. New predictive equations were developed using the following models: model 1 with age, weight, stature, and body mass index (BMI) as predictors; and model 2: model 1 + raw BIA variables (bioimpedance index and phase angle). The accuracy of the new equations at both the group (bias) and individual (within ±10%) levels was tested in the validation group. Three published predictive equations were also compared, with the REE values measured by IC. Results: A total of 2483 adults were included for developing and validating the new equations. All selected formulas, including the new ones, showed a bias of
- Published
- 2021
47. Nutritional risk and eating attitudes in adolescent and young women with anorexia nervosa
- Author
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E. Speranza, O. Di Vincenzo, L. Auriemma, A. De Rosa, Iolanda Cioffi, C. De Caprio, M. Naccarato, S. Stornaiuolo, Fabrizio Pasanisi, and D. Morlino
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Anorexia nervosa (differential diagnoses) ,Endocrinology, Diabetes and Metabolism ,medicine ,Eating attitudes ,Psychiatry ,business ,Nutritional risk - Published
- 2020
48. Nutritional risk screening 2002 and subjective global assessment (SGA) and their association with nutritional parameters in a hospital ward
- Author
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G. D'Onofrio, Fabrizio Pasanisi, Franco Contaldo, Maurizio Marra, Iolanda Cioffi, Lidia Santarpia, C. De Caprio, D. Morlino, E. Speranza, O. Di Vincenzo, and R. Sammarco
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Family medicine ,medicine ,business ,Association (psychology) ,Hospital ward ,Nutritional risk - Published
- 2020
49. Prevalence of sarcopenia in overweight women with breast cancer
- Author
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Maurizio Marra, E. Speranza, O. Di Vincenzo, G. Arpino, Iolanda Cioffi, R. Sammarco, Fabrizio Pasanisi, and D. Morlino
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,Breast cancer ,business.industry ,Endocrinology, Diabetes and Metabolism ,Internal medicine ,Sarcopenia ,medicine ,Overweight ,medicine.symptom ,medicine.disease ,business - Published
- 2020
50. Changes in dietary habits of women with breast cancer: preliminary results of a randomized controlled trial
- Author
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Fabrizio Pasanisi, C. Repetti, M. Naccarato, G. Buono, Iolanda Cioffi, E. Speranza, Lidia Santarpia, D. Morlino, O. Di Vincenzo, and G. Arpino
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,Breast cancer ,Randomized controlled trial ,law ,business.industry ,Endocrinology, Diabetes and Metabolism ,Internal medicine ,medicine ,medicine.disease ,business ,law.invention - Published
- 2020
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