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This study follows the behaviour of seven genotypes of cotton (Gossypium hirsutum), cultivated on the sandy soils of Dăbuleni, with the aim of diversifying the range of plants tolerant to climatic factors in southern Oltenia. Observation of vegetative characteristics such as plant height, number of sympodia, number of flowers in the first decade of flowering and quantitative characteristics such as boll weight, fibre weight, seed weight and number of seeds / plant were the object of the study. Research on cotton plant development was correlated with climatic data recorded by the weather station of Dăbuleni RDSPCS, during the growing season from plant sowing in the field to boll formation. Following the study and showing positive results, The Beli-Lom genotype stood out in terms of flowering yield and fibre percentage, and the Cirpan-539 and Beli-Iskar genotypes had positive vegetative growth yield.

Resume La remission spontanee de la maladie de Cushing est un evenement extremement rare. Nous decrivons un cas representatif et proposons une revue systematique des cas precedemment rapportes dans la litterature. Presentation de cas : une femme de 51 ans diagnostiquee avec la maladie de Cushing a subi un traitement unique avec de la metyrapone pendant neuf mois. Deux mois apres l’arret du traitement, elle a ete admise pour une insuffisance renale aigue. Apres encore quatre mois, en juin 2020, il n’y avait aucun signe d’hypercortisolisme, que ce soit cliniquement ou biochimiquement, ou d’hypocortisolisme, chez notre patient. Un an plus tard, elle est toujours en remission. Cas rapportes dans la litterature : sur 23 patients (dont notre cas), 87 % etaient des femmes avec un âge median de 32 ans. Parmi ceux qui avaient des tumeurs radiologiquement visibles, 10 patients avaient des microadenomes (44 %), tandis que 7 patients avaient des macroadenomes (30 %). Le delai moyen entre le diagnostic et la remission spontanee etait de 5 mois, plus court dans les macroadenomes (1 mois) que dans les microadenomes (13,5 mois). Avant la remission spontanee, les traitements etaient : l’absence de traitement (65 %), les inhibiteurs steroidiens (22 %), la surrenalectomie bilaterale et l’autotransplantation surrenale (5 %), la surrenalectomie bilaterale partielle (4 %), la chirurgie hypophysaire incomplete (4 %). L’apoplexie tumorale hypophysaire etait l’evenement incrimine le plus frequent (91 %), documente radiologiquement chez 43 % des patients. La periode moyenne de remission au cours du suivi etait de 28 mois, les remissions allant de 6 a 130 mois. Une recidive de la maladie de Cushing est survenue chez 39 % (n = 9) des patients. Bien que plusieurs mecanismes responsables de ce phenomene aient ete proposes, l’apoplexie tumorale hypophysaire cliniquement manifeste ou infra-clinique, cette derniere se presentant parfois de maniere atypique, semble etre l’evenement incrimine le plus frequent. Les medecins doivent en etre conscients, et un suivi regulier est obligatoire en raison de son imprevisibilite.

The ability of TiO2 to generate reactive oxygen species under UV radiation makes it an efficient candidate in antimicrobial studies. In this context, the preparation of TiO2 microparticles coated with Ca- and Cu-based composite layers over which Cu(II), Cu(I), and Cu(0) species were identified is presented here. The obtained materials were characterized by a wide range of analytical methods, such as X-ray diffraction, electron microscopy (TEM, SEM), X-ray photoelectron (XPS), and UV-VIS spectroscopy. The antimicrobial efficiency was evaluated using qualitative and quantitative standard methods and standard clinical microbial strains. A significant aspect of this composite is that the antimicrobial properties were evidenced both in the presence and absence of the light, as result of competition between photo and electrical effects. However, the antibacterial effect was similar in darkness and light for all samples. Because no photocatalytic properties were found in the absence of copper, the results sustain the antibacterial effect of the electric field (generated by the electrostatic potential of the composite layer) both under the dark and in light conditions. In this way, the composite layers supported on the TiO2 microparticles’ surface can offer continuous antibacterial protection and do not require the presence of a permanent light source for activation. However, the antimicrobial effect in the dark is more significant and is considered to be the result of the electric field effect generated on the composite layer.

The interconnection of nanotechnology and medicine could lead to improved materials, offering a better quality of life and new opportunities for biomedical applications, moving from research to clinical applications. Magnetite nanoparticles are interesting magnetic nanomaterials because of the property-depending methods chosen for their synthesis. Magnetite nanoparticles can be coated with various materials, resulting in “core/shell” magnetic structures with tunable properties. To synthesize promising materials with promising implications for biomedical applications, the researchers functionalized magnetite nanoparticles with silica and, thanks to the presence of silanol groups, the functionality, biocompatibility, and hydrophilicity were improved. This review highlights the most important synthesis methods for silica-coated with magnetite nanoparticles. From the presented methods, the most used was the Stöber method; there are also other syntheses presented in the review, such as co-precipitation, sol-gel, thermal decomposition, and the hydrothermal method. The second part of the review presents the main applications of magnetite-silica core/shell nanostructures. Magnetite-silica core/shell nanostructures have promising biomedical applications in magnetic resonance imaging (MRI) as a contrast agent, hyperthermia, drug delivery systems, and selective cancer therapy but also in developing magnetic micro devices.

Polycystic ovary syndrome (PCOS), characterized by oligo-anovulation and androgen excess is considered a high-risk condition for metabolic disorders. Herein, untargeted metabolomics analysis was applied to women with PCOS, aiming to provide deeper insights into lipidomics biomarkers signature of PCOS, for better diagnosis and management. This was a cross-sectional study in which 15 Caucasian women with PCOS and 15 Caucasian healthy, age-matched women were enrolled. Lipidomics analysis was performed using Ultra-High Performance Liquid Chromatography-Quadrupole Time of Flight Electrospray Mass Spectrometry. Partial Least Squares Discriminant Analysis retrieved the most important discriminative metabolites. Significantly increased levels of triacylglycerol (18:2/18:2/0-18:0) in addition to cholestane-3beta, 5alpha, 6beta-triol (18:0/0:0) and cholestane-5alpha (18:1/0:0) appeared as valuable variables to differentiate subjects with PCOS from controls. Acyl-carnitine 2-hydroxylauroylcarnitine was significantly elevated in PCOS in opposition to decreased phosphocholines metabolites (18:1/18:4, 18:3/18:2), to suggest a metabolic pattern linked to lipid peroxidation. A high fat intake or reduced fat energy consumption during nighttime due to diminished ability to switch to lipid oxidation during fasting time possibly contribute to hypertriglyceridemia found in PCOS. Furthermore, inflammatory mediators including metabolites of the prostaglandin (PG) E2 pathway and oxo-leukotrienes (LT) were increased in patients with PCOS. Potential lipidomics biomarkers were identified that could stratify between women with PCOS and healthy controls. The results show particular alterations in acylglycerols, PGs and LTs and phosphocholines and carnitine metabolites. The lipidomics profiles of PCOS indicate a higher risk of developing metabolic diseases.

Nonfunctioning pituitary adenomas (NFPA) are very rare during pregnancy since fertility is usually impaired. A 31 year old hirsute woman was referred to the Endocrine Clinic for a large pituitary tumor, discovered at 35 weeks of gestation. She complained of increasing headache and abnormal vision, particularly in her left eye in the previous few weeks. An MRI scan showed a pituitary mass: 3.1 ×2.7 ×1.8 cm (LL/CC/AP) with suprasellar extension, and compression of the optic chiasm. Serum prolactin and the results of other endocrine investigations were normal, so she was diagnosed with NFPA. Both inducing labour or medication (bromocriptine) administration while proceeding to a safe term for pregnancy were considered. However, we chose to only follow her closely. There was no further deterioration and, at 38 weeks, a caesarian section was performed and a healthy boy was delivered. Two weeks after delivery, she underwent craniotomy (by right lateral subfrontal approach) with resection of the NFPA, followed by complete regression of the visual disturbances. The postoperative MRI demonstrated empty sella and no residual tumor, while the hormonal evaluation detected no significant pituitary insufficiency. Although cost-effective, combined histologic and immunophenotypic studies, especially extended IHC tests, can reduce the incidence of misdiagnosed large-cell lymphoma. As exemplified in this present case, obtaining appropriate and sufficient tissue from the tumor could possibly increase the chance of finding an accurate diagnosis.

In this study, zinc oxide nanoparticles were synthesized through a simple co-precipitation method starting from zinc acetate dihydrate and sodium hydroxide as reactants. The as-obtained ZnO nanoparticles were morphologically and structurally characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), photocatalytic activity, and by determining the antimicrobial activity against Gram-negative and Gram-positive bacteria. The XRD pattern of the zinc oxide nanoparticles showed the wurtzite hexagonal structure, and its purity highlighted that the crystallinity correlated with the presence of a single product, zinc oxide. The ZnO nanoparticles have an average crystallite size of 19 ± 11 nm, which is in accordance with the microscopic data. ZnO nanoparticles were tested against methyl orange, used as a model pollutant, and it was found that they exhibit strong photocatalytic activity against this dye. The antibacterial activity of ZnO nanoparticles was tested against Gram-negative and Gram-positive strains (Escherichia coli, Staphylococcus aureus, and Candida albicans). The strongest activity was found against Gram-positive bacteria (S. aureus).

The worldwide prevalence and incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) and of NENs, in general, have been increasing recently. While valuing the considerable progress made in the treatment strategies for GEP-NEN in recent years, patients with advanced, metastasized disease still have a poor prognosis, which calls for urgent novel therapies. The immune system plays a dual role: both host-protecting and “tumor-promoting.” Hence, immunotherapy is potentially a powerful weapon to help NEN patients. However, although recent successes with checkpoint inhibitors have shown that enhancing antitumor immunity can be effective, the dynamic nature of the immunosuppressive tumor microenvironment presents significant hurdles to the broader application of these therapies. Studies led to their approval in NEN of the lung and Merkel cell carcinoma, whereas results in other settings have not been so encouraging. Oncolytic viruses can selectively infect and destroy cancer cells, acting as an in situ cancer vaccine. Moreover, they can remodel the tumor microenvironment toward a T cell-inflamed phenotype. Oncolytic virotherapy has been proposed as an ablative and immunostimulatory treatment strategy for solid tumors that are resistant to checkpoint inhibitors alone. Future efforts should focus on finding the best way to include immunotherapy in the GEP-NEN treatment scenario. In this context, this study aims at providing a comprehensive generalized review of the immune checkpoint blockade and the oncolytic virotherapy use in GEP-NENs that might improve GEP-NEN treatment strategies.

The use of bacterial cellulose (BC) in skin wound treatment is very attractive due to its unique characteristics. These dressings&rsquo, wet environment is an important feature that ensures efficient healing. In order to enhance the antimicrobial performances, bacterial-cellulose dressings were loaded with amoxicillin and bacitracin as antibacterial agents. Infrared characterization and thermal analysis confirmed bacterial-cellulose binding to the drug. Hydration capacity showed good hydrophilicity, an efficient dressing&rsquo, s property. The results confirmed the drugs&rsquo, presence in the bacterial-cellulose dressing&rsquo, s structure as well as the antimicrobial efficiency against Staphylococcus aureus and Escherichia coli. The antimicrobial assessments were evaluated by contacting these dressings with the above-mentioned bacterial strains and evaluating the growth inhibition of these microorganisms.

Molecular predictive biomarkers represent an essential tool for the future of personalized oncotherapy. Gastro-entero-pancreatic neuroendocrine neoplasms are a heterogeneous group of epithelial tumors with a steadyincrease in incidence and prevalence. Their effective management depends on early diagnosis, personalizedrisk stratification, and monitoring response to therapy. A crucial element is identifying accurate biomarkers topredict/monitor therapeutic responses, assess drug resistance, and quantify residual disease in a reproducibleand less invasive way. Taking into consideration their role in cell differentiation, cell proliferation, apoptosisand tumor development, microRNAs have gained interest as potential prognostic markers and treatmentresponse predictors in neuroendocrine neoplasms. This review is the first to summarize the available dataon the possible role of microRNAs in evaluating the efficacy of somatostatin analogs treatment in gastro-entero-pancreatic neuroendocrine neoplasms. Although the literature is scarce, the let-7 family targetingphosphoinositide 3 kinase – protein kinase B 1 – mammalian target of rapamycin signaling pathway mightrepresent a promising biomarker with potential clinical benefit, but further research is required beforetheir eventual clinical application. Furthermore, the ambiguous molecular mechanisms of neuroendocrineproliferation and the undefined signaling pathway of somatostatin analogs should encourage future researchin this field that may lead to a different clinical approach to neuroendocrine disease.

Polycystic ovary syndrome (PCOS) is a major health problem with a heterogeneous hormone-imbalance and clinical presentation across the lifespan of women. Increased androgen production and abnormal gonadotropin-releasing hormone (GnRH) release and gonadotropin secretion, resulting in chronic anovulation are well-known features of the PCOS. The brain is both at the top of the neuroendocrine axis regulating ovarian function and a sensitive target of peripheral gonadal hormones and peptides. Current literature illustrates that neurotransmitters regulate various functions of the body, including reproduction, mood and body weight. Neurotransmitter alteration could be one of the reasons for disturbed GnRH release, consequently directing the ovarian dysfunction in PCOS, since there is plenty evidence for altered catecholamine metabolism and brain serotonin or opioid activity described in PCOS. Further, the dysregulated neurotransmitter and neuropeptide profile in PCOS could also be the reason for low self-esteem, anxiety, mood swings and depression or obesity, features closely associated with PCOS women. Can these altered central brain circuits, or the disrupted gut-brain axis be the tie that would both explain and link the pathogenesis of this disorder, the occurrence of depression, anxiety and other mood disorders as well as of obesity, insulin resistance and abnormal appetite in PCOS? This review intends to provide the reader with a comprehensive overview of what is known about the relatively understudied, but very complex role that neurotransmitters, neuropeptides and gut peptides play in PCOS. The answer to the above question may help the development of drugs to specifically target these central and peripheral circuits, thereby providing a valuable treatment for PCOS patients that present to the clinic with GnRH/LH hypersecretion, obesity or psychiatric manifestations.

Background and objectives: Medical devices such as catheters are used on a large scale to treat heart and cardiovascular diseases. Unfortunately, they present some important drawbacks (structure failure, calcifications, infections, thrombosis, etc.), with the main side effects occurring due to adhesion and proliferation of bacteria and living cells on the surface of the implanted devices. The aim of this work is to modify the surface of polyvinyl chloride (PVC), an affordable biocompatible material, in order to reduce these aforementioned side effects. Materials and Methods: The surface of PVC was modified by depositing a thin layer also of PVC that incorporates an active substance, dicoumarol (a well-known anticoagulant), by spin coating process. The modified surfaces were analyzed by Fourier-transform infrared (FT-IR) microscopy, Fourier-transform infrared (FT-IR) spectroscopy, Ultraviolet-visible spectroscopy (UV-VIS), and Scanning electron microscopy (SEM) in order to determine the surface morphology and behavior. The samples were tested for Gram-positive (S. aureus ATCC 25923) and Gram-negative (P. aeruginosa ATCC 27853) standard strains from American Type Culture Collection (ATCC). Results: The material obtained had a smooth surface with a uniform distribution of dicoumarol, which is released depending on the deposition parameters. The concentration of dicoumarol at the surface of the material and also the release rate is important for the applications for which the surface modification was designed. PVC modified using the proposed method showed a good ability to prevent salt deposition and decreased the protein adhesion, and the resistance to bacterial adherence was improved compared with standard PVC.

During the past few years, researchers have focused their attention on developing innovative nanocomposite polymeric membranes with applications in water purification. Natural and synthetic polymers were considered, and it was proven that chitosan-based materials presented important features. This review presents an overview regarding diverse materials used in developing innovative chitosan-based nanocomposite polymeric membranes for water purification. The first part of the review presents a detailed introduction about chitosan, highlighting the fact that is a biocompatible, biodegradable, low-cost, nontoxic biopolymer, having unique structure and interesting properties, and also antibacterial and antioxidant activities, reasons for using it in water treatment applications. To use chitosan-based materials for developing nanocomposite polymeric membranes for wastewater purification applications must enhance their performance by using different materials. In the second part of the review, the performance’s features will be presented as a consequence of adding different nanoparticles, also showing the effect that those nanoparticles could bring on other polymeric membranes. Among these features, pollutant’s retention and enhancing thermo-mechanical properties will be mentioned. The focus of the third section of the review will illustrate chitosan-based nanocomposite as polymeric membranes for water purification. Over the last few years, researchers have demonstrated that adsorbent nanocomposite polymeric membranes are powerful, important, and potential instruments in separation or removal of pollutants, such as heavy metals, dyes, and other toxic compounds presented in water systems. Lastly, we conclude this review with a summary of the most important applications of chitosan-based nanocomposite polymeric membranes and their perspectives in water purification.

Severe infections caused by Methicillin-resistant Staphylococcus aureus (MRSA) and other bacteria are responsible for millions of deaths each year. One of the main objectives of future antibiotic strategies is to develop new anti-infective agents, which would be highly effective and drug-resistant (antimicrobial resistance being currently exhibited by MRSA), using specific antibodies conjugated to thermally active nanomaterials such as NIR-responsive photothermal contrast agents. Multi-walled carbon nanotubes (MWCNTs) covalently functionalized with immunoglobulin G (IgG, an antagonist of Staphylococcal protein A-SpA, which is a MRSA membrane associated protein) were selectively delivered (at various concentrations and incubation times) into MRSA bacteria. Following treatment, cultures were irradiated using an 808 nm 2 w laser diode. The post irradiation death rate ranged from 39.6% (for 1 mg/L) to 79.2% (for 50 mg/L) at 60 seconds (p < 0.001), while at 30 minutes, the death rate increased from 45.2% (1 mg/L) to 85.72% (50 mg/L), p < 0.001. Irradiated MRSAs treated with MWCNTs alone (control) for 60 seconds and 30 minutes, at concentrations ranging from 1 mg/L to 50 mg/L, resulted in significantly lower death rates (7.1-34.1% for 60 seconds, 11.7-48.8% for 30 minutes). Using IgG molecules bound to MWCNTs, followed by laser irradiation, we obtained a very efficacious nanoshell-mediated laser therapy of individual MRSA agents providing highly localized killing effects for IgG-MWCNTs targeted bacteria.

Polycystic ovary syndrome (PCOS) is a common female endocrine disorder, which still remains largely unsolved in terms of etiology and pathogenesis despite important advances in our understanding of its genetic, epigenetic, or environmental factor implications. It is a heterogeneous disease, frequently associated with insulin resistance, chronic inflammation, and oxidative stress and probably accompanied with subclinical cardiovascular disease (CVD) and some malignant lesions as well, such as endometrial cancer. Discrepancies in the clinical phenotype and progression of PCOS exist between different population groups, which nuclear genetic studies have so far failed to explain. Over the last years, mitochondrial dysfunction has been increasingly recognized as an important contributor to an array of diseases. Because mitochondria are under the dual genetic control of both the mitochondrial and nuclear genomes, mutations within either DNA molecule may result in deficiency in respiratory chain function that leads to a reduced ability to produce cellular adenosine-5'-triphosphate and to an excessive production of reactive oxygen species. However, the association between variants in mitochondrial genome, mitochondrial dysfunction, and PCOS has been investigated to a lesser extent. May mutations in mitochondrial DNA (mtDNA) become an additional target of investigations on the missing PCOS heritability? Are mutations in mtDNA implicated in the initiation and progression of PCOS complications, e.g., CVDs, diabetes mellitus, cancers?

The paper presents the results obtained following the theoretical research of one rotation mechanism, regarding the dynamic behavior for one modern transfer system, a manipulator or robot in cylindrical co-ordinates, which belongs to a molding technological module based on the hydraulic presses. Using the mathematical modeling and the computer simulation, we can know the dynamic behavior of the rotation mechanism. Analyzing the dynamic behavior, it can identify the parameters with sensitive behavior and, finally, it can optimize the dynamic regimes according to the real requests of driving, in order to satisfy the technological processes.

Pancreatic cancer (PC) is one of the most lethal solid tumor in humans, with an overall 5-year survival rate of less than 5%. Thermally active carbon nanotubes have already brought to light promising results in PC research and treatment. We report here the construct of a nano-biosystem based on multi-walled carbon nanotubes and polyethylene glycol (PEG) molecules validated through AFM, UV-Vis and DLS. We next studied the photothermal effect of these PEG-ylated multi-walled carbon nanotubes (5, 10 and 50 μg/mL, respectively) on pancreatic cancer cells (PANC-1) and further analyzed the molecular and cellular events involved in cell death occurrence. Using cell proliferation, apoptosis, membrane polarization and oxidative stress assays for ELISA, fluorescence microscopy and flow cytometry we show here that hyperthermia following MWCNTs-PEG laser mediated treatment (808 nm, 2W) leads to mitochondrial membrane depolarization that activates the flux of free radicals within the cell and the oxidative state mediate cellular damage in PC cells via apoptotic pathway. Our results are of decisive importance especially in regard with the development of novel nano-biosystems capable to target mitochondria and to synergically act both as cytotoxic drug as well as thermally active agents in order to overcome one of the most common problem met in oncology, that of intrinsic resistance to chemotherapeutics.

Noble metal nanoparticles such as gold nanoparticles can strongly absorb light in the visible region by inducing coherent collective oscillation of conduction band electrons in strong resonance with visible frequencies of light. This phenomenon is frequently termed as surface plasmon resonance (SPR).The main objective was to study the effects of laser photoactivated gold nanoparticles (by means of SPR) on human pancreatic cancer cells.Gold nanoparticles obtained using standard wet chemical methods (with sodium borohydride as a reducing agent) underwent photoexcitation using 2w 808 nm laser and further administered to 1.4E7 pancreatic cancer cell lines. Flow cytometry, transmission electron microscopy, phase contrast microscopy, quantitative proteomics and confocal microscopy combined with immunochemical staining were used to examine the interaction between photo excited gold nanoparticles and pancreatic cancer cells.The study shows that phonon-phonon interactions following laser photoexcitation of gold nanoparticles exhibit increased intracellular uptake, as well as mitochondrial swelling, closely followed by mitochondrial inner membrane permeabilization and depolarization. This unique data may represent a major step in mitochondria-targeted anticancer therapies using laser-activated gold nanoparticles.

Ioana Ilie,1 Razvan Ilie,2 Teodora Mocan,3 Flaviu Tabaran,4 Cornel Iancu,4 Lucian Mocan4 1Department of Endocrinology, 2Department of Microbiology, 3Department of Physiology, 4Third Surgery Clinic, Department of Nanomedicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania Abstract: Recent data in the literature support the role of nicotinamide (NA) as a pharmacologic agent that stimulates pancreatic beta-cells to produce insulin in vitro. There are data showing that carbon nanotubes may be useful in initiating and maintaining cellular metabolic responses. This study shows that administration of multiwalled carbon nanotubes (MWCNTs) functionalized with nicotinamide (NA-MWCNTs) leads to significant insulin production compared with individual administration of NA, MWCNTs, and a control solution. Treatment of 1.4E7 cells for 30 minutes with NA-MWCNTs at concentrations ranging from 1 mg/L to 20 mg/L resulted in significantly increased insulin release (0.18 ± 0.026 ng/mL for 1 mg/L, 0.21 ± 0.024 ng/mL for 5 mg/L, and 0.27 ± 0.028 ng/mL for 20 mg/L). Thus, compared with cells treated with NA only (0.1 ± 0.01 ng/mL for 1 mg/L, 0.12 ± 0.017 ng/mL for 5 mg/L, and 0.17 ± 0.01 ng/mL for 20 mg/L) we observed a significant positive effect on insulin release in cells treated with NA-MWCNTs. The results were confirmed using flow cytometry, epifluorescence microscopy combined with immunochemistry staining, and enzyme-linked immunosorbent assay techniques. In addition, using immunofluorescence microscopy techniques, we were able to demonstrate that MWCNTs enhance insulin production via the macrophage migration inhibitory factor pathway. The application and potential of NA combined with MWCNTs as an antidiabetic agent may represent the beginning of a new chapter in the nanomediated treatment of diabetes mellitus. Keywords: carbon nanotubes, NA, insulin-producing cells, insulin, macrophage migration inhibitory factor, diabetes mellitus

The paper presents the results following the theoretical research of one prehension mechanism regarding the dynamic behavior for one modern transfer systems, a manipulator or robot in cylindrical co-ordinates, which belongs to a molding technological module based on the hydraulic presses. Using the mathematical modeling and the computer simulation, it can identify the parameters with sensitive behavior and, finally, it can optimize the dynamic regimes according to the real requests of driving.

The paper presents the theoretical results of extensive research on the dynamic behavior of linear hydraulic motors, carried out in INOE 2000-IHP, in the framework of the NUCLEU Programmer. The research has been conducted both theoretically and experimentally, but, in this paper, is presented only the theoretical research. Theoretical research has taken place with the modern means of mathematical modeling and computer numerical simulation. The article presents some theoretical interested results obtained in the research, results that are of real scientific interest, but, also, with practical value through their use in the design of fluid power components and equipments.

The paper presents an electro-hydraulic linear actuator used at Tuzla Sea Survival School on the Cabin Emergency and Escape Trainer CEET B732 developed by author, which implements their research about electro-hydraulic system driven by common PLCs. This kind of control can be very easy to meet hydraulic process requirements, improve the system stability, reliability and automation level. Most of PLCs used on servo-hydraulic applications are dedicated DSP based. The actuator functionality was implemented as a software application using specialized PLC software tools — ladder diagram. The management of actuator moving scenarios is implemented in a database stored on PLC; for a moving scenario the successive position values, once per second, are recorded as a table in nonvolatile memory. The authors proposed solution and the experimental results validated that the approach is well fitted on fast processes like servo-hydraulics.

The paper presents the results following the theoretical research of one vertical elevation mechanism regarding the dynamic behavior for one modern transfer systems, a manipulator or robot in cylindrical co-ordinates, which belongs to a molding technological module based on the hydraulic presses. Using the mathematical modeling and the computer simulation, it can identify the parameters with sensitive behavior and, finally, it can optimize the dynamic regimes according to the real requests of driving.

We report the photo-thermal properties of single and double wall carbon nanotubes (CNT) dispersed in various solvents with different concentrations when exposed to near infrared nm laser irradiations. All these studies were correlated to the dispersivity of CNT in various solvents. The observed temperature increase of the various nanotube solutions was found to be determined by the concentration of the optically active nanotubes, as determined from their Raman scattering spectra, which are resonant in the spectral range of the laser excitation. Such findings could significantly improve the understanding of the optically active CNT species, their overall laser induced-heating levels, and thus reducing the amount of the CNT required for bio-medical photothermal applications to limit the possible undesired cytotoxic effects that occur at high nanotube concentrations. Our studies open up the possibility of using selective species of CNT as effective low-toxic photo thermal agents for cancer targeting and ablation.