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30 results on '"Ioan Buraga"'

1. Three case series involving progresive motor deficit

Author

Bogdan Pana, Alina Anghel, Iuliana Nicola-Antoniu, and Ioan Buraga

Subjects
muscular dystrophy, myotonic dystrophy, steinert’s disease, motor deficit, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

The muscular dystrophies are a group of inherited, non-inflammatory disorders, consisting of progressive muscle wasting, without peripheral or central nerve involvement. We present a series of three cases involving progressive motor deficit and their different evolutions. The first case is about a 57-year-old female patient, without a significant family medical history, presenting for progressive motor deficit involving the shoulder and pelvic muscles, started at the age of 20-year-old, when she was diagnosed with a sporadic form of limb-girdle muscular dystrophy. The second case is about a 27-year-old male, diagnosed with muscular dystrophy at the age of 15. The third case is about a 43-year-old male admitted for frequent falls and weakness of the limbs, mainly distal, started 10 years ago. He was diagnosed with myotonic dystrophy. Although there is still no treatment for muscular dystrophies, the pathology is under investigation in clinical trials.

Published
2016
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2. Chiari malformation type I – case report and review of literature

Author

Ioana Cociasu, Mihnea Pastia, Irene Davidescu, Ioan Buraga, and Bogdan O. Popescu

Subjects
type i, syringomyelia, syrinx, arnold-chiari, headache, tonsil herniation, congenital, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Chiari malformations are congenital defects involving the cerebral structures in the posterior fossa. They range from asymptomatic cerebellar tonsil herniation beside the brainstem, to cerebellar aplasia. These conditions were first described in 1890 and are still considered a rare occurrence even though they are more likely under-diagnosed rather than rare. We report the case of a 44-year-old woman with Chiari type I malformation and associated cervical syringomyelia.

Published
2016
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3. Brain MRI findings in acute hyperammonemic encephalopathy secondary to ischemic hepatitis: case report and review of the literature

Author

Ana-Maria Vladila, Dan-Andrei Mitrea, Sanda Nica, Gabriela Mihailescu, and Ioan Buraga

Subjects
acute hepatic encephalopathy, hyperammonemia, ischemic hepatitits, insular cortex, flair hypersignal, restriction of diffusion, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Acute encephalopathy is frequently seen in Neurology and Internal Medicine Departments, it makes for a wide spectrum of neuropsychiatric abnormalities, but its brain magnetic resonance imaging appearance in the adult population is not well recognised. We present the case of an acute hyperammonemic encephalopathy in the setting of ischemic hepatitis secondary to global heart failure and its MRI findings with a review of the literature.

Published
2016
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4. Recurrent meningioma after initial resection surgery – case report

Author

Ioana Cociasu, Irene Davidescu, Ioan Buraga, and Bogdan O. Popescu

Subjects
meningioma, multiple meningiomas, recurrent meningioma, seizures, radiotherapy, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

The most common tumours of the central nervous system, meningiomas are frequently diagnosed by accident when patients undergo imaging studies of the brain for other reasons. Most patients lack symptoms and thus can live their whole lives without knowing they have a brain tumour. Less fortunate patients seek medical advice for troubling symptoms – like seizures or disturbances of the cranial nerves – get surgery for the excision of the tumour and years later fi nd out their tumour has come back. We are presenting the case of such a patient with a recurrent parietal meningioma.

Published
2015
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5. Progressive Multifocal Leukoencephalopathy Associated to Multiple Sclerosis Therapies: Review of the literature

Author

Ana-Maria Vladila, Dan-Andrei Mitrea, Sanda Maria Nica, and Ioan Buraga

Subjects
pml, jc virus, multiple sclerosis, natalizumab, fingolimod, dimethyl fumarate, alemtuzamab, pcr, cerebral mri demyelinating lesion, plasma exchange, mirtazapine, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection associated with the reactivation of the JC virus, causing a severe demyelination within the central nervous system in patients with immunosuppression caused by disease or secondary to use of drugs. Several therapies used in the treatment of MS have reported cases of associated PML, most cases being related to Natalizumab treatment. In this article we review specific MS medication with a reported risk for PML, and also revise PML epidemiology, pathogenesis, treatment and available approaches on therapy in patients at high risk for developing this infection.

Published
2015
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6. Anticoagulation complications in a patient with prior cerebral venous thrombosis

Author

Ioana Cociasu, Irene Davidescu, Ioan Buraga, and Bogdan Ovidiu Popescu

Subjects
cerebral venous thrombosis, intracerebral hemorrhage, vitamin k antagonists, hereditary thrombophilia, malignancy, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Cerebral venous thrombosis is a rare form of stroke treated with anticoagulant compounds both in the acute phase as well as in long term. We present the case of a 56-year-old female that suffered two different forms of stroke in 2 years.

Published
2015
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7. Socio-economic issues in Alzheimer's disease. Resilience and Alzheimer's

Author

Cristian Dinu Popescu, Dan Trofin, Daniela Trofin, Daniel Alexa, Romeo Dobrin, Bogdan Ignat, Ioan Buraga, and Daniela Matei

Subjects
dementia, alzheimer’s disease, social, economics, caregiver, burden, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Alzheimer’s Disease (AD) is the most common form of dementia in the old population, carrying a major negative influence upon society and caregivers, as its socio-economic implications are enormous. The devastating impact of AD is also due to the fact that the diagnosis is difficult to be established in an early stage, and in spite of the advances made in medicine, the new symptomatic and disease modifying therapies have still only a mild though promising positive effect. Caregivers are exposed to increased risk of disease themselves, due to the high burden which predisposes them to stress related psychological, behavioral or cognitive disorders. Greater caregiver resilience can predict lower levels of depression. Also, a strong external support system was associated with increased resilience. Establishing a pattern for the behavioral and psychological manifestations in dementia can have as direct effect developing better coping strategies in order to reduce stress and the burden of the caregivers. Some data regarding the economic and social impact of AD, as well as facts and numbers from our local centers will be described in the following pages.

Published
2014
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8. Neurofibromatosis - case presentation

Author

Ioan Buraga, Daniela Trasca, Mihaela Selescu, Cristina Baetu, Oana Milea, and Adelina Serban

Subjects
café au lait, lisch nodules, neurofi bromas, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

We are presenting the case of a 43 year old man, without significant pathological antecedents, who accused back pain with irradiation on the back of the thigh and the right calf, which were associated with paresthesia at the same level. Symptoms appeared a year ago, when the patient was on symptomatic treatments with minimal results. On the generally examination there are found fifteen café au lait spots, distributed on the torso and limbs with the diameter above 15 mm, axillary hyperpigmentation, ten cutaneous neurofibromas with the same distribution and Lisch nodules in the iris. We proceeded to MRI examination of the lumbar spine that reveals an important irregular thickening, tortue with pseudotumoral aspect, predominantly in the extraforaminal and peripheral path and less in the intraforaminal of nerve roots from T12 to the sacral roots; widening of the conjugation foramina; changes are more pronounced in the sacral plexus (left > right), the terminal segments presenting the appearance of „pelvic mass“ – MRI compatible with plexiform neurofibromas aspect. The final step was the histopathological examination which confirmed the diagnostic. The particularity of this case is that this patient was very late diagnosed, despite the fact that he had many pathognomonic elements of neurofibromatosis, and his symptomatology was rough, usually this disease is diagnosed in childhood or as an young adult.

Published
2014
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9. Chronic subdural hematoma: a case report and review of the literature

Author

Ana-Maria Vladila, Dan-Andrei Mitrea, Sanda Nica, Georgiana Pavel, Gabriela Mihailescu, Ioan Buraga, and Doru Baltateanu

Subjects
chronic subdural hematoma, elderly, epilepsy, atrial fi brillation, antiplatelet/ anticoagulant medication, large craniotomy, bleeding, subdural hematoma recurrence, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Chronic subdural hematoma is a common type of intracranial hemorrhage with higher incidence and unpredictable evolution among elderly people. We present the case of a 73 years old male patient, diagnosed in October 2013 with subacute bilateral subdural hematomas who was admitted in our clinic for worsening of motor function in his left limbs. The cerebral CT performed revealed a right massive chronic subdural hematoma which met the criteria for neurosurgical approach requiring a large craniotomy for complete removal. In this article we review the risk factors associated with an unpredictable evolution and postoperative subdural hematoma recurrence in the elderly.

Published
2014
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10. Vitamin D intoxication in a patient with relapsing-remitting multiple sclerosis – case report

Author

Ioana Cociasu, Irene Davidescu, Ioan Buraga, and Bogdan Ovidiu Popescu

Subjects
vitamin d, toxicity, multiple sclerosis, relapsing-remitting, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Lately, vitamin D has been a hot topic among multiple sclerosis specialists. Vitamin D supplementation is being thoroughly researched in order to establish whether or not it is useful in the treatment of multiple sclerosis. We present the case of a patient with multiple sclerosis, who, after searching online, decided to administer vitamin D supplements in high doses; subsequently he was admitted to our for-clinic symptoms consistent with vitamin D intoxication.

Published
2015
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12. Multiple cerebral cavernous malformations - a case report

Author

Ana-Maria Vladila, Georgiana Pavel, Dan Mitrea, Sanda Nica, Gabriela Mihailescu, Irene Davidescu, and Ioan Buraga

Subjects
multiple cerebral cavernomas, symptomatic epilepsy, mri t2*, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Cavernomas are frequent low-flow vascular malformations with a characteristic MRI aspect due to their specific morphology. We present the case of a 64-year old male diagnosed in 2008 with multiple cerebral cavernomas and symptomatic epilepsy, who developed left face, arm and leg paresthesia during the last 6 days. The MRI examination performed in our clinic showed increased number of infracentimetric lesions with no signs of hemorrhage or growth of the previous documented ones. Considering MRI findings and the patient being seizure free for the last three years there is no current indication for invasive treatment. The presence of multiple lesions along with their aspect on T2* MRI sequences suggest a hereditary form in absence of familial history of cerebral cavernous malformations.

Published
2013
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13. Neurocognitive disorder and dysgenesis of corpus callosum

Author

Irene Davidescu, Ruxandra Maria Anton, Gabriela Mihailescu, Delia Parvu, Sanda Maria Nica, Ioan Buraga, and Bogdan O. Popescu

Subjects
corpus callosum, mri, neurocognitive disorder, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

We report the case of a 68 year-old female (O.F.), referred to our clinic for a neurological evaluation after an episode of loss of consciousness that occurred three days before admittance. She was also diagnosed with cognitive impairment (July 2011). Case particularity: the MRI examination, which was the investigation of choice in this case, revealed structural brain abnormalities – dysgenesis of the corpus callosum.

Published
2013
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14. Preexisting neurologic disorder triggered by anesthesia?

Author

Ioana Buraga, Ioan Buraga, and Magda Buraga

Subjects
anesthesia, neurologic defi cit, multiple sclerosis, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Neurologic defi cits appearing after various anesthetic techniques are not always caused by these procedures, also some are attributed to them. Neuraxial blocks – spinal, more often than epidural – have been associated with the postoperative relapse of multiple sclerosis, although the evidence is not strong. The mechanism is unknown but it is speculated that the disease makes the spinal cord more susceptible to the neurotoxic effects of local anesthetics. We present the case of 42-years-old female, scheduled for ureteroscopy for ureteric calculi under spinal anesthesia. Postoperatively she developed various neurological symptoms that together with the paraclinical findings led to the diagnosis of multiple sclerosis.

Published
2013
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15. Corpus callosum dysgenesis and colpocephaly

Author

Roxana Beatrice Ciurea, Gabriela Mihailescu, Ruxandra Maria Anton, Delia Parvu, Sanda Maria Nica, Georgiana Pavel, Ioan Buraga, and Bogdan O. Popescu

Subjects
corpus callosum, dysgenesis, colpocephaly, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

We present the case of T.F., a 28 year-old woman diagnosed with corpus callosum dysgenesis and colpocephaly. The diagnosis is based on cerebral imaging – magnetic resonance imaging (MRI) and computerised tomography (CT)

Published
2013
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16. Sporadic multiple meningiomas - a rare cause of secondary epilepsy

Author

Ruxandra Maria Anton, Gabriela Mihailescu, Sanda Maria Nica, Magdalena Bratu, Delia Parvu, Ioan Buraga, Bogdan O. Popescu, Roxana Beatrice Ciurea, and Georgiana Pavel

Subjects
multiple meningiomas, secondary epilepsy, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

We present the case of a 60 year-old woman diagnosed with meningiomatosis (multiple sporadic meningiomas), in the absence of neurofibromatosis type 2. The cerebral computerized axial tomography (CT scan) revealed six expansive lesions (one isodense and five spontaneously hyperdense partially or completely calcified), which at the cerebral magnetic resonance imaging (MRI) examination showed typical features of meningiomas. Case particularity: the very low incidence of sporadic multiple meningiomas and a rare cause of secondary epilepsy.

Published
2013
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17. 19-year-old female with abdominal pain

Author

Ioan Buraga and Adrian-Florin Dobrescu

Subjects
abdominal pain, neurological defi cit, porfobilinogen, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Porphyria is a group of at least 8 diseases that differ greatly between them. Common feature of these diseases is the accumulation in the body of porphyrins or porphyrin precursors, due to defects of specific enzymes in the biosynthesis of heme. Many symptoms of porphyria are nonspecific and therefore the diagnosis is often delayed. Laboratory tests can confirm or exclude the diagnosis of porphyria. However, certain diagnosis requires demonstration of specific enzyme deficiency. The presented case demonstrates the difficulty in diagnosis of acute intermittent porphyria (AIP) in a young woman without a history of significant pathology.

Published
2013
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18. Behçet disease

Author

Ioan Buraga, Roxana Martin, Adrian Dobrescu, and Magda Buraga

Subjects
behçet disease, recurrent aphthous, uveitis, Medicine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Behçet disease is a form of vasculitis that can lead to ulceration and other lesions. The etiology is not well-defined, but it is characterized by inflammation of the blood vessels. There is no specific pathological test for Behçet disease at present. It is diagnosed clinically by specific patterns of symptoms and repeated outbreaks.

Published
2010
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19. Multiple Sclerosis and Pregnancy: Current Considerations

Author

Ioan Buraga and Roxana-Elena Popovici

Subjects
Technology, Medicine, Science
Abstract

Multiple sclerosis is the most common neurological disease of young adults that causes major disability. In Romania, it is estimated that this disease has a prevalence of 35–40 per 100,000 inhabitants. It is a disease that begins at the age of 20–40 years and is 2-3 times more common in women than in men. More than half of patients with MS develop the disease in their fertile period of life; therefore, MS patients use contraceptive methods while being under our treatment. Since several therapeutic options have been implemented with good efficiency in the disease stabilization, increasingly more patients begin to wonder about the possibility of having a child and about the possible risks of pregnancy. The evolution during pregnancy and the lactation period has been favorable, with lower relapses and side effects comparable to those in the general population. In addition, babies born to mothers with MS have not had a significantly different mean gestational age or birth weight compared to babies born to healthy mothers.

Published
2014
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20. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Author

Ludwig Kappos, Amit Bar-Or, Bruce A C Cree, Robert J Fox, Gavin Giovannoni, Ralf Gold, Patrick Vermersch, Douglas L Arnold, Sophie Arnould, Tatiana Scherz, Christian Wolf, Erik Wallström, Frank Dahlke, Anat Achiron, Lutz Achtnichts, Kadriye Agan, Gulsen Akman-Demir, Alison B Allen, Jack P Antel, Alfredo Rodriguez Antiguedad, Michelle Apperson, Angela M Applebee, Guillermo Izquierdo Ayuso, Masayuki Baba, Ovidiu Bajenaru, Rodica Balasa, Belgin Petek Balci, Michael Barnett, Ann Bass, Veit U Becker, Mihaela Bejinariu, Florian Then Bergh, Arnfin Bergmann, Evanthia Bernitsas, Achim Berthele, Virender Bhan, Felix Bischof, Randall John Bjork, Gregg Blevins, Matthias Boehringer, Thomas Boerner, Robert Bonek, James D Bowen, Allen Bowling, Alexey N Boyko, Cavit Boz, Vera Bracknies, Stefan Braune, Vincenzo Brescia Morra, Bruno Brochet, Waldemar Brola, Paul Kenneth Brownstone, Miroslav Brozman, Donald Brunet, Ioan Buraga, Margaret Burnett, Mathias Buttmann, Helmut Butzkueven, Jonathan Cahill, Jonathan C Calkwood, William Camu, Mark Cascione, Giovani Castelnovo, Diego Centonze, Joao Cerqueira, Andrew Chan, Andrea Cimprichova, Stanley Cohan, Giancarlo Comi, Jill Conway, Joanna A Cooper, John Corboy, Jorge Correale, Brian Costell, David A Cottrell, Patricia K Coyle, Matthew Craner, Liying Cui, Luis Cunha, Anna Czlonkowska, Ana Martins da Silva, Joao de Sa, Jérôme de Seze, Marc Debouverie, Jan Debruyne, Danny Decoo, Gilles Defer, Tobias Derfuss, Norma H Deri, Bhupesh Dihenia, Peter Dioszeghy, Vladimir Donath, Benedicte Dubois, Martin Duddy, Pierre Duquette, Gilles Edan, Husnu Efendi, Stanton Elias, Peter J Emrich, Bonaventura Casanova Estruch, Evgeniy P Evdoshenko, Juergen Faiss, Alexander S Fedyanin, Wolfgang Feneberg, Jiske Fermont, Oscar Fernandez Fernandez, Francisco Coret Ferrer, Katharina Fink, Helen Ford, Corey Ford, Ada Francia, Mark Freedman, Benjamin Frishberg, Simonetta Galgani, George P Garmany, Klaus Gehring, Jeffrey Gitt, Claudio Gobbi, Lawrence P Goldstick, Rafael Arroyo Gonzalez, Francois Grandmaison, Nikolaos Grigoriadis, Olga Grigorova, Luigi Maria Edoardo Grimaldi, Jeffrey Gross, Katrin Gross-Paju, Mark Gudesblatt, Daniel Guillaume, Judith Haas, Viera Hancinova, Anca Hancu, Orla Hardiman, Arndt Harmjanz, Fedor R Heidenreich, G J D Hengstman, Joseph Herbert, Mark Herring, Suzanne Hodgkinson, Olaf M Hoffmann, Werner E Hofmann, William D Honeycutt, Le Hanh Hua, Dehui Huang, Yining Huang, DeRen Huang, Raymond Hupperts, Piroska Imre, Alan Keith Jacobs, Gabor Jakab, Elzbieta Jasinska, Kenichi Kaida, Jolanta Kalnina, Ara Kaprelyan, Guntis Karelis, Dimitrios Karussis, Amos Katz, Farit A Khabirov, Bhupendra Khatri, Takashi Kimura, Ilya Kister, Rasa Kizlaitiene, Eleonora Klimova, Juergen Koehler, Aparna Komatineni, Anselm Kornhuber, Krisztina Kovacs, Agnes Koves, Wojciech Kozubski, Georgi Krastev, Lauren B Krupp, Egon Kurca, Christoph Lassek, Guy Laureys, Liesly Lee, Eckart Lensch, Fritz Leutmezer, Hongzeng Li, Ralf A Linker, Michael Linnebank, Petra Liskova, Cristina Llanera, Jiahong Lu, Andreas Lutterotti, Jan Lycke, Richard Macdonell, Maciej Maciejowski, Mathias Maeurer, Rim V Magzhanov, Eva-Maria Maida, Lina Malciene, Yang Mao-Draayer, Girolama Alessandra Marfia, Clyde Markowitz, Vasileios Mastorodimos, Klotild Matyas, Jose Meca-Lallana, Juan Antonio Garcia Merino, Ioan Gheorghe Mihetiu, Ivan Milanov, Aaron E Miller, Andrejs Millers, Massimiliano Mirabella, Masanori Mizuno, Xavier Montalban, Lilina Montoya, Masahiro Mori, Stefanie Mueller, Jin Nakahara, Yuji Nakatsuji, Scott Newsome, Richard Nicholas, A Scott Nielsen, Esmaeil Nikfekr, Ugo Nocentini, Chiyoko Nohara, Kyoichi Nomura, Miroslav M Odinak, Tomas Olsson, B W van Oosten, Celia Oreja-Guevara, Patrick Oschmann, James Overell, Andrew Pachner, Gyula Panczel, Massimo Pandolfo, Caroline Papeix, Liliana Patrucco, Jean Pelletier, Raul Piedrabuena, Misha Pless, Udo Polzer, Krisztian Pozsegovits, Daiva Rastenyte, Sebastian Rauer, Gerd Reifschneider, Roberto Rey, Syed A Rizvi, Derrick Robertson, Jose Martinez Rodriguez, David Rog, Homayoun Roshanisefat, Vernon Rowe, Csilla Rozsa, Susan Rubin, Stanislaw Rusek, Francesco Saccà, Takahiko Saida, Antonio Vasco Salgado, Victoria Eugenia Fernandez Sanchez, Kalina Sanders, Maria Satori, Denis V Sazonov, Elio Angelo Scarpini, Eugen Schlegel, Myriam Schluep, Stephan Schmidt, Erich Scholz, H M Schrijver, Matthias Schwab, Raymond Schwartz, James Scott, Krzysztof Selmaj, Stuart Shafer, Basil Sharrack, Ivan A Shchukin, Yuko Shimizu, Penko Shotekov, Arno Siever, Karl-Otto Sigel, Scott Silliman, Magdolna Simo, Mihaela Simu, Vladimiro Sinay, Antonio Escartin Siquier, Aksel Siva, Ondrej Skoda, Andrew Solomon, Martin Stangel, Dusan Stefoski, Brian Steingo, Igor D Stolyarov, Pavel Stourac, Katrin Strassburger-Krogias, Erik Strauss, Olaf Stuve, Ivaylo Tarnev, Antonios Tavernarakis, Cristina Ramo Tello, Murat Terzi, Veronika Ticha, Marina Ticmeanu, Klaus Tiel-Wilck, Toomas Toomsoo, Niall Tubridy, Mark J Tullman, Hayrettin Tumani, Peter Turcani, Ben Turner, Antonio Uccelli, Francisco Javier Olascoaga Urtaza, Marta Vachova, Attila Valikovics, Silke Walter, Bart Van Wijmeersch, Ludo Vanopdenbosch, Joerg R Weber, Sara Weiss, Robert Weissert, Timothy West, Heinz Wiendl, Sandrine Wiertlewski, Brigitte Wildemann, Barbara Willekens, L H Visser, Galina Vorobeychik, Xianhao Xu, Takashi Yamamura, Yi N Yang, Sergio Martinez Yelamos, Michael Yeung, Alan Zacharias, Marvin Zelkowitz, Uwe Zettl, Meini Zhang, Hongyu Zhou, Ulf Zieman, Tjalf Ziemssen, Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital, University of Basel, Basel, Center for Neuroinflammation and Neurotherapeutics, and Multiple Sclerosis Division, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, Mellen Centre for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, Department of Neurology St. Josef-Hospital, Ruhr University Bochum, Germany, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Montreal Neurological Institute, McGill University, Montreal, QC, Canada, NeuroRx Research, Montreal, QC, Novartis Pharma AG, Lycalis, Brussels, AP-HM, CHU Timone, Pole de Neurosciences Cliniques, Department of Neurology, Marseille, France., Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Kappos, Ludwig, Bar-Or, Amit, Cree, Bruce A C, Fox, Robert J, Giovannoni, Gavin, Gold, Ralf, Vermersch, Patrick, Arnold, Douglas L, Arnould, Sophie, Scherz, Tatiana, Wolf, Christian, Wallström, Erik, Dahlke, Frank, Achiron, Anat, Achtnichts, Lutz, Agan, Kadriye, Akman-Demir, Gulsen, Allen, Alison B, Antel, Jack P, Antiguedad, Alfredo Rodriguez, Apperson, Michelle, Applebee, Angela M, Ayuso, Guillermo Izquierdo, Baba, Masayuki, Bajenaru, Ovidiu, Balasa, Rodica, Balci, Belgin Petek, Barnett, Michael, Bass, Ann, Becker, Veit U, Bejinariu, Mihaela, Bergh, Florian Then, Bergmann, Arnfin, Bernitsas, Evanthia, Berthele, Achim, Bhan, Virender, Bischof, Felix, Bjork, Randall John, Blevins, Gregg, Boehringer, Matthia, Boerner, Thoma, Bonek, Robert, Bowen, James D, Bowling, Allen, Boyko, Alexey N, Boz, Cavit, Bracknies, Vera, Braune, Stefan, Brescia Morra, Vincenzo, Brochet, Bruno, Brola, Waldemar, Brownstone, Paul Kenneth, Brozman, Miroslav, Brunet, Donald, Buraga, Ioan, Burnett, Margaret, Buttmann, Mathia, Butzkueven, Helmut, Cahill, Jonathan, Calkwood, Jonathan C, Camu, William, Cascione, Mark, Castelnovo, Giovani, Centonze, Diego, Cerqueira, Joao, Chan, Andrew, Cimprichova, Andrea, Cohan, Stanley, Comi, Giancarlo, Conway, Jill, Cooper, Joanna A, Corboy, John, Correale, Jorge, Costell, Brian, Cottrell, David A, Coyle, Patricia K, Craner, Matthew, Cui, Liying, Cunha, Lui, Czlonkowska, Anna, da Silva, Ana Martin, de Sa, Joao, de Seze, Jérôme, Debouverie, Marc, Debruyne, Jan, Decoo, Danny, Defer, Gille, Derfuss, Tobia, Deri, Norma H, Dihenia, Bhupesh, Dioszeghy, Peter, Donath, Vladimir, Dubois, Benedicte, Duddy, Martin, Duquette, Pierre, Edan, Gille, Efendi, Husnu, Elias, Stanton, Emrich, Peter J, Estruch, Bonaventura Casanova, Evdoshenko, Evgeniy P, Faiss, Juergen, Fedyanin, Alexander S, Feneberg, Wolfgang, Fermont, Jiske, Fernandez, Oscar Fernandez, Ferrer, Francisco Coret, Fink, Katharina, Ford, Helen, Ford, Corey, Francia, Ada, Freedman, Mark, Frishberg, Benjamin, Galgani, Simonetta, Garmany, George P, Gehring, Klau, Gitt, Jeffrey, Gobbi, Claudio, Goldstick, Lawrence P, Gonzalez, Rafael Arroyo, Grandmaison, Francoi, Grigoriadis, Nikolao, Grigorova, Olga, Grimaldi, Luigi Maria Edoardo, Gross, Jeffrey, Gross-Paju, Katrin, Gudesblatt, Mark, Guillaume, Daniel, Haas, Judith, Hancinova, Viera, Hancu, Anca, Hardiman, Orla, Harmjanz, Arndt, Heidenreich, Fedor R, Hengstman, G J D, Herbert, Joseph, Herring, Mark, Hodgkinson, Suzanne, Hoffmann, Olaf M, Hofmann, Werner E, Honeycutt, William D, Hua, Le Hanh, Huang, Dehui, Huang, Yining, Huang, Deren, Hupperts, Raymond, Imre, Piroska, Jacobs, Alan Keith, Jakab, Gabor, Jasinska, Elzbieta, Kaida, Kenichi, Kalnina, Jolanta, Kaprelyan, Ara, Karelis, Gunti, Karussis, Dimitrio, Katz, Amo, Khabirov, Farit A, Khatri, Bhupendra, Kimura, Takashi, Kister, Ilya, Kizlaitiene, Rasa, Klimova, Eleonora, Koehler, Juergen, Komatineni, Aparna, Kornhuber, Anselm, Kovacs, Krisztina, Koves, Agne, Kozubski, Wojciech, Krastev, Georgi, Krupp, Lauren B, Kurca, Egon, Lassek, Christoph, Laureys, Guy, Lee, Liesly, Lensch, Eckart, Leutmezer, Fritz, Li, Hongzeng, Linker, Ralf A, Linnebank, Michael, Liskova, Petra, Llanera, Cristina, Lu, Jiahong, Lutterotti, Andrea, Lycke, Jan, Macdonell, Richard, Maciejowski, Maciej, Maeurer, Mathia, Magzhanov, Rim V, Maida, Eva-Maria, Malciene, Lina, Mao-Draayer, Yang, Marfia, Girolama Alessandra, Markowitz, Clyde, Mastorodimos, Vasileio, Matyas, Klotild, Meca-Lallana, Jose, Merino, Juan Antonio Garcia, Mihetiu, Ioan Gheorghe, Milanov, Ivan, Miller, Aaron E, Millers, Andrej, Mirabella, Massimiliano, Mizuno, Masanori, Montalban, Xavier, Montoya, Lilina, Mori, Masahiro, Mueller, Stefanie, Nakahara, Jin, Nakatsuji, Yuji, Newsome, Scott, Nicholas, Richard, Nielsen, A Scott, Nikfekr, Esmaeil, Nocentini, Ugo, Nohara, Chiyoko, Nomura, Kyoichi, Odinak, Miroslav M, Olsson, Toma, van Oosten, B W, Oreja-Guevara, Celia, Oschmann, Patrick, Overell, Jame, Pachner, Andrew, Panczel, Gyula, Pandolfo, Massimo, Papeix, Caroline, Patrucco, Liliana, Pelletier, Jean, Piedrabuena, Raul, Pless, Misha, Polzer, Udo, Pozsegovits, Krisztian, Rastenyte, Daiva, Rauer, Sebastian, Reifschneider, Gerd, Rey, Roberto, Rizvi, Syed A, Robertson, Derrick, Rodriguez, Jose Martinez, Rog, David, Roshanisefat, Homayoun, Rowe, Vernon, Rozsa, Csilla, Rubin, Susan, Rusek, Stanislaw, Saccà, Francesco, Saida, Takahiko, Salgado, Antonio Vasco, Sanchez, Victoria Eugenia Fernandez, Sanders, Kalina, Satori, Maria, Sazonov, Denis V, Scarpini, Elio Angelo, Schlegel, Eugen, Schluep, Myriam, Schmidt, Stephan, Scholz, Erich, Schrijver, H M, Schwab, Matthia, Schwartz, Raymond, Scott, Jame, Selmaj, Krzysztof, Shafer, Stuart, Sharrack, Basil, Shchukin, Ivan A, Shimizu, Yuko, Shotekov, Penko, Siever, Arno, Sigel, Karl-Otto, Silliman, Scott, Simo, Magdolna, Simu, Mihaela, Sinay, Vladimiro, Siquier, Antonio Escartin, Siva, Aksel, Skoda, Ondrej, Solomon, Andrew, Stangel, Martin, Stefoski, Dusan, Steingo, Brian, Stolyarov, Igor D, Stourac, Pavel, Strassburger-Krogias, Katrin, Strauss, Erik, Stuve, Olaf, Tarnev, Ivaylo, Tavernarakis, Antonio, Tello, Cristina Ramo, Terzi, Murat, Ticha, Veronika, Ticmeanu, Marina, Tiel-Wilck, Klau, Toomsoo, Tooma, Tubridy, Niall, Tullman, Mark J, Tumani, Hayrettin, Turcani, Peter, Turner, Ben, Uccelli, Antonio, Urtaza, Francisco Javier Olascoaga, Vachova, Marta, Valikovics, Attila, Walter, Silke, Van Wijmeersch, Bart, Vanopdenbosch, Ludo, Weber, Joerg R, Weiss, Sara, Weissert, Robert, West, Timothy, Wiendl, Heinz, Wiertlewski, Sandrine, Wildemann, Brigitte, Willekens, Barbara, Visser, L H, Vorobeychik, Galina, Xu, Xianhao, Yamamura, Takashi, Yang, Yi N, Yelamos, Sergio Martinez, Yeung, Michael, Zacharias, Alan, Zelkowitz, Marvin, Zettl, Uwe, Zhang, Meini, Zhou, Hongyu, Zieman, Ulf, Ziemssen, Tjalf, and EXPAND Clinical Investigators

Subjects
Adult, Male, 0301 basic medicine, Relative risk reduction, medicine.medical_specialty, Adolescent, Placebo, law.invention, Cohort Studies, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Multiple Sclerosis, Chronic Progressive / drug therapy, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Internal medicine, Benzyl Compounds, Clinical endpoint, Humans, Medicine, ComputingMilieux_MISCELLANEOUS, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Expanded Disability Status Scale, Dose-Response Relationship, Drug, business.industry, Hazard ratio, General Medicine, Middle Aged, Multiple Sclerosis, Chronic Progressive, Fingolimod, Treatment Outcome, Settore M-EDF/01 - METODI E DIDATTICHE DELLE ATTIVITÀ MOTORIE, 030104 developmental biology, Siponimod, chemistry, Disease Progression, Azetidines, Female, Settore MED/26 - Neurologia, Human medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery, medicine.drug
Abstract

Summary Background No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of siponimod, a selective sphingosine 1-phosphate (S1P) receptor 1,5 modulator, on disability progression in patients with SPMS. Methods This event-driven and exposure-driven, double-blind, phase 3 trial was done at 292 hospital clinics and specialised multiple sclerosis centres in 31 countries. Using interactive response technology to assign numbers linked to treatment arms, patients (age 18–60 years) with SPMS and an Expanded Disability Status Scale score of 3·0–6·5 were randomly assigned (2:1) to once daily oral siponimod 2 mg or placebo for up to 3 years or until the occurrence of a prespecified number of confirmed disability progression (CDP) events. The primary endpoint was time to 3-month CDP. Efficacy was assessed for the full analysis set (ie, all randomly assigned and treated patients); safety was assessed for the safety set. This trial is registered with ClinicalTrials.gov, number NCT01665144. Findings 1651 patients were randomly assigned between Feb 5, 2013, and June 2, 2015 (1105 to the siponimod group, and 546 to the placebo group). One patient did not sign the consent form, and five patients did not receive study drug, all of whom were in the siponimod group. 1645 patients were included in the analyses (1099 in the siponimod group and 546 in the placebo). At baseline, the mean time since first multiple sclerosis symptoms was 16·8 years (SD 8·3), and the mean time since conversion to SPMS was 3·8 years (SD 3·5); 1055 (64%) patients had not relapsed in the previous 2 years, and 918 (56%) of 1651 needed walking assistance. 903 (82%) patients receiving siponimod and 424 (78%) patients receiving placebo completed the study. 288 (26%) of 1096 patients receiving siponimod and 173 (32%) of 545 patients receiving placebo had 3-month CDP (hazard ratio 0·79, 95% CI 0·65–0·95; relative risk reduction 21%; p=0·013). Adverse events occurred in 975 (89%) of 1099 patients receiving siponimod versus 445 (82%) of 546 patients receiving placebo; serious adverse events were reported for 197 (18%) patients in the siponimod group versus 83 (15%) patients in the placebo group. Lymphopenia, increased liver transaminase concentration, bradycardia and bradyarrhythmia at treatment initiation, macular oedema, hypertension, varicella zoster reactivation, and convulsions occurred more frequently with siponimod than with placebo. Initial dose titration mitigated cardiac first-dose effects. Frequencies of infections, malignancies, and fatalities did not differ between groups. Interpretation Siponimod reduced the risk of disability progression with a safety profile similar to that of other S1P modulators and is likely to be a useful treatment for SPMS. Funding Novartis Pharma AG.

Published
2018
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21. THREE CASE SERIES INVOLVING PROGRESIVE MOTOR DEFICIT

Author

Pharmacy, Bucharest, Romania, Iuliana Nicola-Antoniu, Alina Anghel, Bogdan Pana, and Ioan Buraga

Subjects
muscular dystrophy, medicine.medical_specialty, myotonic dystrophy, Series (mathematics), lcsh:R, steinert’s disease, motor deficit, lcsh:Medicine, lcsh:RC346-429, Physical medicine and rehabilitation, Neurology, medicine, Neurology (clinical), Motor Deficit, Psychology, lcsh:Neurology. Diseases of the nervous system
Abstract

The muscular dystrophies are a group of inherited, non-inflammatory disorders, consisting of progressive muscle wasting, without peripheral or central nerve involvement. We present a series of three cases involving progressive motor deficit and their different evolutions. The first case is about a 57 year old female patient, without a significant family medical history, presenting for progressive motor deficit involving the shoulder and pelvic muscles, started at the age of 20 year old, when she was diagnosed with a sporadic form of limb-girdle muscular dystrophy. The second case is about a 27 year old male, diagnosed with muscular dystrophy at the age of 15. The third case is about a 43 year old male admitted for frequent falls and weakness of the limbs, mainly distal, started 10 years ago. He was diagnosed with myotonic dystrophy. Although there is still no treatment for muscular dystrophies, the pathology is under investigation in clinical trials.

Published
2016

22. RECURRENT MENINGIOMA AFTER INITIAL RESECTION SURGERY – CASE REPORT

Author

Ioan Buraga, Ioana Cociasu, Bucharest Pharmacy, Irene Davidescu, and Bogdan Ovidiu Popescu

Subjects
medicine.medical_specialty, business.industry, lcsh:R, lcsh:Medicine, meningioma, lcsh:RC346-429, Surgery, Resection, recurrent meningioma, Neurology, medicine, Neurology (clinical), business, radiotherapy, lcsh:Neurology. Diseases of the nervous system, Recurrent Meningioma, multiple meningiomas, seizures
Abstract

The most common tumours of the central nervous system, meningiomas are frequently diagnosed by accident when patients undergo imaging studies of the brain for other reasons. Most patients lack symptoms and thus can live their whole lives without knowing they have a brain tumour. Less fortunate patients seek medical advice for troubling symptoms – like seizures or disturbances of the cranial nerves – get surgery for the excision of the tumour and years later fi nd out their tumour has come back. We are presenting the case of such a patient with a recurrent parietal meningioma.

Published
2015

23. ANTICOAGULATION COMPLICATIONS IN A PATIENT WITH PRIOR CEREBRAL VENOUS THROMBOSIS

Author

Ioan Buraga, Bucharest Pharmacy, Irene Davidescu, Bogdan Ovidiu Popescu, and Ioana Cociasu

Subjects
medicine.medical_specialty, business.industry, lcsh:R, lcsh:Medicine, cerebral venous thrombosis, medicine.disease, intracerebral hemorrhage, lcsh:RC346-429, Surgery, vitamin k antagonists, Venous thrombosis, hereditary thrombophilia, Neurology, medicine, Neurology (clinical), cardiovascular diseases, business, lcsh:Neurology. Diseases of the nervous system, malignancy
Abstract

Cerebral venous thrombosis is a rare form of stroke treated with anticoagulant compounds both in the acute phase as well as in long term. We present the case of a 56 year old female that suffered two different forms of stroke in 2 years.

Published
2015

24. Levodopa-carbidopa intestinal gel in advanced Parkinson's: Final results of the GLORIA registry

Author

Lacramioara Perju-Dumbrava, Lars Bergmann, Anjum Misbahuddin, Francesc Valldeoriola, Stephen Wørlich Pedersen, Chris van der Linden, Stephan Bohlhalter, Erik H. Danielsen, David, Maurizio Zibetti, Björn Hauptmann, Oriol De Fabregues, Ashley Yegin, Martin Nevrly, K. Ray Chaudhuri, Jeff Blackie, M.M. Ponsen, Christoph Redecker, Anne Jeanjean, Kenn Freddy Pedersen, Jan Kassubek, Mihaela Simu, Philippe Busson, Barbara A. Pickut, Pierre R. Burkhard, József Attila Szász, Per Odin, Bogdan Ovidiu Popescu, Ene Amalia, Angelo Antonini, Robert Jech, Thomas E. Kimber, Matthias Bode, Kari Anne Bjørnarå, Ivan Milanov, Bruno Bergmans, Espen Dietrichs, Luc Defebvre, Christofer Lundqvist, Jesper Clausen, Michaela Kaiserová, Valérie Delvaux, Werner Poewe, Martin Wolz, Sophie Dethy, Jaime Kulisevsky, Cleanthe Spanaki, Anette Storstein, Michel Rijntjes, F. Ory Magne, Pietro Marano, T. van Laar, Tove Henriksen, Christian Winkler, Ovidiu Bajenaru, Spyridon Konitsiotis, Michel Van Zandijcke, Ransmayr Gerhard, F. Viallet, Koray Onuk, Guy Arnold, Kirsten Hahn, Jo Leenders, Mariachiara Sensi, Jorge Hernández-Vara, Zikos Panayiotis, Nicola Modugno, Volker Tomantschger, Matilde Calopa, Zvezdan Pirtošek, Paul Bourgeois, Graziano Gusmaroli, Christoph Schrader, Ioan Buraga, Víctor Puente, Rejko Krüger, Alexander Storch, Tatiana Witjas, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie, GLORIA study co-investigators, and Movement Disorder (MD)

Subjects
0301 basic medicine, Male, Parkinson's disease, Neurology, Routine patient care, Levodopa-carbidopa intestinal gel, Motor symptoms, Non-motor symptoms, Antiparkinson Agents, Levodopa, 0302 clinical medicine, Quality of life, Gériatrie - gérontologie, Medicine, Registries, Parkinson Disease/drug therapy, Intubation, Gastrointestinal, Carbidopa/administration & dosage, Carbidopa, Parkinson Disease, Middle Aged, Safety profile, Drug Combinations, Female, medicine.symptom, Gastrointestinal, medicine.medical_specialty, Levodopa/administration & dosage, 03 medical and health sciences, Rating scale, Internal medicine, Neurologie, Antiparkinson Agents/administration & dosage, Humans, Aged, business.industry, medicine.disease, nervous system diseases, ddc:616.8, 030104 developmental biology, Mood, Dyskinesia, Levodopa carbidopa, Physical therapy, Geriatrics and Gerontology, Neurology (clinical), Human medicine, Intubation, business, Gels, 030217 neurology & neurosurgery
Abstract

Introduction This registry evaluated the 24-month safety and efficacy of levodopa-carbidopa intestinal gel (LCIG) treatment in advanced Parkinson's disease (PD) patients under routine clinical care. Methods Motor fluctuations, dyskinesia, non-motor symptoms, quality of life, and safety were evaluated. Observations were fully prospective for treatment-naïve patients (60% of patients) and partially retrospective for patients with ≤12 months of pre-treatment with LCIG (40% of patients). Hours of “On” and “Off” time were assessed with a modified version of the Unified Parkinson's Disease Rating Scale part IV items 32 and 39. Results Overall, 375 patients were enrolled by 75 movement disorder centers in 18 countries and 258 patients completed the registry. At 24 months LCIG treatment led to significant reductions from baseline in “Off” time (hours/day) (mean ± SD = −4.1 ± 3.5, P < 0.001), “On” time with dyskinesia (hours/day) (−1.1 ± 4.8, P = 0.006), Non-Motor Symptom Scale total (−16.7 ± 43.2, P < 0.001) and individual domains scores, and Parkinson's Disease Questionnaire-8 item total score (−7.1 ± 21.0, P < 0.001). Adverse events deemed to have a possible/probable causal relationship to treatment drug/device were reported in 194 (54%) patients; the most frequently reported were decreased weight (6.7%), device related infections (5.9%), device dislocations (4.8%), device issues (4.8%), and polyneuropathy (4.5%). Conclusions LCIG treatment led to sustained improvements in motor fluctuations, non-motor symptoms particularly sleep/fatigue, mood/cognition and gastrointestinal domains, as well as quality of life in advanced PD patients over 24 months. Safety events were consistent with the established safety profile of LCIG., 0, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017
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25. Neurofibromatosis - case presentation

Author

Cristina Baetu, Adelina Serban, Mihaela Selescu, Ioan Buraga, Daniela Trasca, and Oana Milea

Subjects
musculoskeletal diseases, café au lait, medicine.medical_specialty, business.industry, neurofi bromas, lcsh:R, lcsh:Medicine, Case presentation, medicine.disease, Dermatology, lcsh:RC346-429, body regions, Neurology, medicine, Neurology (clinical), Neurofibromatosis, business, lisch nodules, lcsh:Neurology. Diseases of the nervous system
Abstract

We are presenting the case of a 43 year old man, without significant pathological antecedents, who accused back pain with irradiation on the back of the thigh and the right calf, which were associated with paresthesia at the same level. Symptoms appeared a year ago, when the patient was on symptomatic treatments with minimal results. On the generally examination there are found fifteen café au lait spots, distributed on the torso and limbs with the diameter above 15 mm, axillary hyperpigmentation, ten cutaneous neurofibromas with the same distribution and Lisch nodules in the iris. We proceeded to MRI examination of the lumbar spine that reveals an important irregular thickening, tortue with pseudotumor aspect, predominantly in the extraforaminal and peripheric path and less in the intraforaminal of nerve roots from T12 to the sacral roots; widening of the conjugation foramina; changes are more pronounced in the sacral plexus (left > right), the terminal segments presenting the appearance of „pelvic mass“ – MRI compatible with plexiform neurofibromas aspect. The final step was the histopathological examination which confirmed the diagnostic. The particularity of this case is that this patient was very late diagnosed, despite the fact that he had many pathognomonic elements of neurofibromatosis, and his symptomatology was rough, usually this disease is diagnosed in childhood or as an young adult.

Published
2014
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26. HEMIBALLISMUS AFTER HEMORRHAGIC STROKE

Author

Bogdan Ovidiu Popescu, Ioan Buraga, Vlad Claudiu Stefanescu, Irene Davidescu, and Bucharest Pharmacy

Subjects
Hemiballismus, medicine.medical_specialty, business.industry, lcsh:R, lcsh:Medicine, medicine.disease, lcsh:RC346-429, nervous system diseases, Neurology, Internal medicine, Cardiology, medicine, Neurology (clinical), business, Stroke, lcsh:Neurology. Diseases of the nervous system
Abstract

Ischemic or hemorrhagic stroke may be accompanied by movement disorders (1), either hyperkinetic or hypokinetic. Hyperkinetic movement disorders after stroke comprise dystonia (2-4), chorea with or without hemiballismus (5), tremor (6), parkinsonism (7), segmental or focal myoclonus, athetosis, pseudathetosis, and asterixis (8). Hemiballismus is a movement disorder characterized by involuntary, arrythmic, and large amplitude excursion of a limb, usually from a proximal joint, witn an element of rotation (9). Ballismus is explainable with lesions in the subthalamic nuclei, cerebral cortex, corpus striatum, thalamus and brainstem. (10) The frequency of post-stroke abnormal movements is unclear, the prevalence in a swiss registry being 1% with an incidence of 0.08% per year (8). Of them, hemichorea-hemiballismus is the most common, while dystonia is the next most common disorder (11).

Published
2015

27. BEHÇET DISEASE – CASE PRESENTATION

Author

Ioan Buraga, Roxana Martin, Adrian Dobrescu, and Magda Buraga

Subjects
behçet disease, lcsh:R, uveitis, lcsh:Medicine, recurrent aphthous, lcsh:Neurology. Diseases of the nervous system, lcsh:RC346-429
Abstract

Behçet disease is a form of vasculitis that can lead to ulceration and other lesions. The etiology is not welldefined, but it is characterized by inflammation of the blood vessels. There is no specific pathological test for Behçet disease at present. It is diagnosed clinically by specific patterns of symptoms and repeated outbreaks.

Published
2010

28. PHYSICAL REHABILITATION AND LIFE QUALITY IN MULTIPLE SCLEROSIS

Author

Ioan Buraga, Irene Davidescu, Sanda Nica, and Gabriela Mihailescu

Subjects
treatment, lcsh:R, lcsh:Medicine, multiple sclerosis, lcsh:Neurology. Diseases of the nervous system, lcsh:RC346-429, rehabilitation
Abstract

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of young people, which affects life quality, with social and psychological effects. The new era of treatments in MS, with drugs influencing immunomodulatory systems made possible a new approach of these patients, in efforts to make them capable to perform their activities as much as possible. Physical rehabilitation is an important mean for making patients with MS to accept their disease and to favourise their independence longer time. Patients should be encouraged to perform daily, or at least 2-3 times a week, a programme of physical exercises under the supervision of a specialist. Performing exercises in MS leads to a lot of benefits, not only physical ones, but also psychological ones and for overall health and finally to quality of life improvement. Physical therapy should be combined with psychological support, for limitation of negative impact of a chronic disease in young people. We must not forget that depression, anxiety, and in late stages of the disease, cognitive decline can interfere with life quality, so it is necessary to manage in a correct way all these aspects.

Published
2009

30. MAN OF 81 YEARS OLD WITH SUBACUTE INSTALLED PARAPARESIS.

Author

Ioan, Buraga

Subjects
*ISCHEMIA, *BLOOD circulation disorders, *TUMORS, *MEDICAL imaging systems, *NEUROBIOLOGY
Abstract

Total medullar syndrome section has multiple causes including the most common are trauma with or without bone involvement, spinal tumors, myelitis and ischemia. At various stages of clinical presentation are written plus some features of each etiology in part. Differential diagnosis often requires additional investigation and interdisciplinary consultation that could be a major emergency. [ABSTRACT FROM AUTHOR]

Published
2011
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