Jonas Leuermann, Daniel Collado, Alejandro Sánchez-Postigo, Cole A. Chapman, Robert Halir, Adrián Fernández-Gavela, Vladimir Stamenkovic, Ryan C. Bailey, Patricia Ramirez-Priego, Íñigo Molina-Fernández, Laura M. Lechuga, Ezequiel Perez-Inestrosa, European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Andalucía, [Leuermann,J, Stamenkovic,V, Perez-Inestrosa,E, Collado,D, Halir,R, Molina-Fernández,Í] Bionand Center for Nanomedicine and Biotechnology, Málaga, Spain. [Leuermann,J, Sánchez-Postigo,A, Molina-Fernández,Í] Departamento de Ingeniería de Comunicaciones, University of Málaga, ETSI Telecomunicación, Málaga, Spain. [Stamenkovic,V, Collado,D] Departamento de Química Orgánica, Facultad de Ciencias, University of Málaga, Málaga, Spain. [Ramirez-Priego,P, Lechuga,LM] Nanobiosensors and Bioanalytical Applications Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, BIST and CIBER-BBN Campus UAB, Barcelona, Spain. [Fernández-Gavela,A] Departamento de Física, Universidad de Oviedo, Oviedo, Spain. [Chapman,CA, Bailey,RC] Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Horizon 2020 Framework Programme (EuroNanoMed 3-H2020 DrNanoDAII), Ministerio de Economía y Competitividad (2019/PCI 2019-2, CTQ2017-86994-R, SEV-2017-0706), Junta de Andalucía, Proyectos Excelencia-Retos (P18-RT-1453, P18-RT-793), Fondos Europeos de Desarrollo Regional (CTQ2016-75870-P, PID2019-104293GB-I00, RD16/0006/0012, TEC2016-80718-R, UMA18-FEDERJA-007, UMA18-FEDERJA-219), and H2020 Marie Skłodowska-Curie Actions (713721).
Over the past two decades, integrated photonic sensors have been of major interest to the optical biosensor community due to their capability to detect low concentrations of molecules with label-free operation. Among these, interferometric sensors can be read-out with simple, fixed-wavelength laser sources and offer excellent detection limits but can suffer from sensitivity fading when not tuned to their quadrature point. Recently, coherently detected sensors were demonstrated as an attractive alternative to overcome this limitation. Here we show, for the first time, to the best of our knowledge, that this coherent scheme provides sub-nanogram per milliliter limits of detection in C-reactive protein immunoassays and that quasi-balanced optical arm lengths enable operation with inexpensive Fabry–Perot-type lasers sources at telecom wavelengths., Horizon 2020 Framework Programme (EuroNanoMed 3-H2020 DrNanoDAII); Ministerio de Economía y Competitividad (2019/PCI 2019-2, CTQ2017-86994-R, SEV-2017-0706); Junta de Andalucía, Proyectos Excelencia-Retos (P18-RT-1453, P18-RT-793); Fondos Europeos de Desarrollo Regional (CTQ2016-75870-P, PID2019-104293GB-I00, RD16/0006/0012, TEC2016-80718-R, UMA18-FEDERJA-007, UMA18-FEDERJA-219); H2020 Marie Skłodowska-Curie Actions (713721).