1. A New Bacteriophage Pseudomonas Phage Ka1 from a Tributary Stream of Lake Baikal.
- Author
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Fedorova, M. S., Gatina, A. E., Ilyina, V. N., Yadykova, L. L., Drukker, V. V., Gorshkova, A. S., Kayumov, A. R., and Trizna, E. Y.
- Subjects
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PSEUDOMONAS , *PSEUDOMONAS aeruginosa , *BACTERIOPHAGES , *INTEGRASES , *RECOMBINASES , *LAKES , *GENTAMICIN - Abstract
The bacteriophage Pseudomonas phage Ka1 was isolated from the water of a tributary stream of Lake Baikal, in the area of discharge of treated wastewater of the city of Slyudyanka. The bacteriophage genome contains 46 092 bp and has a 50% G+C pairs (AN OP455935.1). It exhibits 91% identity with the Pseudomonas phage PSA37 genome, belonging to Bruynoghevirus from the class Caudoviricetes suggesting that Ka1 is a new representative of Luz24-like phages (Bruynoghevirus). The bacteriophage lyzes 62% of P. aeruginosa clinical isolates and increases the efficiency of gentamicin, ciprofloxacin, imipenem and meropenem by 4–8-fold against these bacteria. Integrases, transposases and recombinases have not been identified in the genome of the bacteriophage Pseudomonas phage Ka1; which allows using it in the complex therapy of infections caused by P. aeruginosa. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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