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1. Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy

Author

Iwamuro, Masaya, Tanaka, Takehiro, Ennishi, Daisuke, Matsueda, Kazuhiro, Yoshioka, Masao, Miyahara, Koji, Sakaguchi, Chihiro, Nishimura, Mamoru, Nagahara, Teruya, Mannami, Tomohiko, Takenaka, Ryuta, Oka, Shohei, Inoue, Masafumi, Takimoto, Hidetaka, Inaba, Tomoki, Kobayashi, Sayo, Toyokawa, Tatsuya, Tsugeno, Hirofumi, Suzuki, Seiyuu, Sawada, Sachiko, Tanaka, Shouichi, Tsuzuki, Takao, and Okada, Hiroyuki

Published
2023
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4. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort

Author

Furumatsu, Keisuke, Sawai, Shigeaki, Goto, Takuma, Okumura, Toshikatsu, Suzuki, Daisuke, Otsuka, Masayuki, Kobori, Ikuhiro, Tamano, Masaya, Koizumi, Mitsuhito, Hiasa, Yoichi, Kawabe, Naoto, Hirooka, Yoshiki, Yamamoto, Satoshi, Asano, Yukio, Inui, Kazuo, Horiguchi, Akihiko, Watanabe, Hiroyuki, Toya, Daishu, Hatayama, Katsuko, Ueki, Toshiharu, Kinoshita, Norikatsu, Sugimoto, Mitsuru, Ohira, Hiromasa, Mukai, Tsuyoshi, Tomita, Eiichi, Iwata, Keisuke, Shimizu, Shogo, Suetsugu, Jun, Shimizu, Masahito, Tsuji, Keiji, Ishida, Ryoko, Ito, Masanori, Furukawa, Ryutaro, Sakamoto, Naoya, Araki, Masahiro, Tanno, Satoshi, Sakamoto, Yasunari, Ito, Tetsuhide, Takai, Satoshi, Ikeya, Shinichi, Yamada, Takanori, Kudara, Norihiko, Shimizu, Akinori, Hanada, Keiji, Ichiki, Yasunori, Kitada, Hideki, Hifumi, Michio, Kimura, Hiroyuki, Kurosaki, Masayuki, Izumi, Namiki, Sumi, Hajime, Haruta, Jun-ichi, Hayashi, Katsumi, Harada, Ryo, Inoue, Masafumi, Nakamura, Shinichiro, Ito, Tetsuya, Tomishima, Ko, Isayama, Hiroyuki, Oura, Kyoko, Masaki, Tsutomu, Shimokawahara, Naoto, Tanoue, Shirou, Maemura, Kousei, Ido, Akio, Mizushima, Ichiro, Kawano, Mitsuhiro, Yoshida, Katsunori, Naganuma, Makoto, Murata, Miki, Nishio, Akiyoshi, Fujita, Yuji, Teratani, Takuma, Matsubara, Shohei, Tamai, Hironao, Yoshida, Yuu, Azemoto, Ryousaku, Kamata, Ken, Watanabe, Tomohiro, Kurosu, Takahiro, Koizumi, Wasaburou, Fujita, Jun, Seki, Hideyuki, Ueda, Yasuhiro, Fukumoto, Takumi, Kousaki, Takuhiro, Uchida, Kazushige, Ochiai, Toshimasa, Kawasaki, Takeshi, Tanaka, Motohiko, Ishida, Etsuji, Notohara, Kenji, Mori, Hideaki, Mori, Toshiyuki, Kawabata, Hideaki, Miyata, Masatoshi, Sakagami, Junichi, Itoh, Yoshito, Shiokawa, Masahiro, Seno, Hiroshi, Watanabe, Noriko, Naitoh, Itaru, Kataoka, Hiromi, Aoki, Toshinori, Fujishiro, Mitsuhiro, Niihara, Toru, Nishimata, Hiroto, Mitoro, Akira, Yoshiji, Hitoshi, Yoshida, Motoyuki, Ikeda, Masafumi, Tomita, Kengo, Hokari, Ryota, Hayasaka, Kenji, Amano, Yuji, Shioji, Kazuhiko, Hayashi, Kazunao, Terai, Shuji, Nakajima, Michiko, Yamahana, Junya, Matsumoto, Ryusuke, Kikuchi, Hideaki, Kanamori, Akira, Kiriyama, Seiki, Iwatsu, Shinichi, Kato, Yuji, Horiguchi, Shigeru, Yagi, Takahito, Okada, Hiroyuki, Ohkawa, Kazuyoshi, Hirao, Motohiro, Hiramatsu, Naoki, Oza, Noriko, Imamura, Haruo, Baba, Takeshi, Nakano, Shigeru, Shinobi, Tetsuya, Ryozawa, Shomei, Motoya, Masayo, Nakase, Hiroshi, Kinoshita, Noboru, Ito, Kei, Miyake, Tatsuya, Kohge, Naruaki, Tobita, Hiroshi, Joshita, Satoru, Umemura, Takeji, Kawaguchi, Shinya, Ohno, Kazuya, Sonobe, Koichi, Satoh, Akihiko, Shimosegawa, Tooru, Miura, Fumihiko, Yagi, Minami, Sano, Keiji, Tanaka, Atsushi, Kin, Toshifumi, Katanuma, Akio, Koike, Kazuhiko, Miura, Shin, Masamune, Atsushi, Kawashima, Youhei, Kagawa, Tatehiro, Azuma, Seishin, Watanabe, Mamoru, Honjyo, Mitsuyoshi, Itoi, Takao, Honda, Akira, Kobayashi, Katsumasa, Asano, Toru, Kamisawa, Terumi, Mizuno, Suguru, Nishino, Takayoshi, Taniguchi, Hideaki, Tajiri, Kazuto, Yasuda, Ichiro, Tanaka, Yoshiya, Oe, Shinji, Harada, Masaru, Kurata, Masanao, Fukasawa, Mituharu, Enomoto, Nobuyuki, Kawaji, Yuki, Kitano, Masayuki, Nishise, Yuko, Hirakawa, Hidetoshi, Ishizawa, Tetsuya, Ueno, Yoshiyuki, Kaino, Miyuki, Fujimoto, Yuko, Sakaida, Isao, Kubota, Kensuke, Nakazawa, Takahiro, Takikawa, Hajime, Unno, Michiaki, Kawa, Shigeyuki, Nakamura, Seiji, and Okazaki, Kazuichi

Published
2021
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6. Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

Author

Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B, and Hoshi, Minako

Subjects
Alzheimer's Disease, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative, Neurosciences, Dementia, Aging, Acquired Cognitive Impairment, Aetiology, 2.1 Biological and endogenous factors, Neurological, Alzheimer Disease, Amino Acid Sequence, Amyloid beta-Peptides, Animals, Calcium, Cell Death, Cells, Cultured, HEK293 Cells, Homeostasis, Humans, Mass Spectrometry, Models, Biological, Models, Molecular, Molecular Imaging, Molecular Sequence Data, Molecular Weight, Neurons, Peptides, Protein Aggregates, Protein Binding, Rats, Signal Transduction, Sodium, Sodium-Potassium-Exchanging ATPase, NMR, computational modeling, abnormal protein-protein interaction in synapse, hyperexcitotoxicity, protein-protein interaction inhibitors, abnormal protein–protein interaction in synapse, protein–protein interaction inhibitors
Abstract

Neurodegeneration correlates with Alzheimer's disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-derived 10- to 15-nm spherical Aβ oligomers that cause selective degeneration of mature neurons. Here, we show that the ASPD target is neuron-specific Na(+)/K(+)-ATPase α3 subunit (NAKα3). ASPD-binding to NAKα3 impaired NAKα3-specific activity, activated N-type voltage-gated calcium channels, and caused mitochondrial calcium dyshomeostasis, tau abnormalities, and neurodegeneration. NMR and molecular modeling studies suggested that spherical ASPD contain N-terminal-Aβ-derived "thorns" responsible for target binding, which are distinct from low molecular-weight oligomers and dodecamers. The fourth extracellular loop (Ex4) region of NAKα3 encompassing Asn(879) and Trp(880) is essential for ASPD-NAKα3 interaction, because tetrapeptides mimicking this Ex4 region bound to the ASPD surface and blocked ASPD neurotoxicity. Our findings open up new possibilities for knowledge-based design of peptidomimetics that inhibit neurodegeneration in AD by blocking aberrant ASPD-NAKα3 interaction.

Published
2015

9. Effects of Eco-Label Knowledge on Chinese Consumer Preferences for Certified Wood Flooring: A Case Study in Chongqing City

Author

Tan, Qin, Imamura, Kohei, Nagasaka, Kenji, and Inoue, Masafumi

Subjects
Wood flooring -- Labeling -- Market research, Floor covering industry -- Market research -- Licensing, certification and accreditation, Wood products, Marketing research, Business, Forest products industry, International Organization for Standardization, Forest Stewardship Council
Abstract

Expanding the use of eco-labeled wood flooring in China is an important step in achieving the country's sustainable development goals. For a deep understanding of the relationship between the knowledge of the eco-label and consumer preferences for certified wood flooring in China, this study assessed consumers' purchase intention (PI) and price premium (PP) for Forest Stewardship Council (FSC)- and China Environmental Labeling (CEL)-labeled wood flooring versus nonlabeled wood flooring. A total of 367 face-to-face interviews were conducted at building material markets in Chongqing City with visitors planning to purchase wood flooring in March 2018. The results showed, first, that 21 percent of respondents knew the FSC label, and 65 percent of respondents intended to buy FSC-labeled wood flooring with a PP of 41 CNY/[m.sup.2]. Second, 46 percent of respondents knew the CEL label, and 81 percent of respondents intended to buy CEL-labeled wood flooring with a PP of 48 CNY/[m.sup.2]. Third, the knowledge of the FSC label positively affected consumers' PI and PP, but the knowledge of the CEL label only influenced PI for certified wood flooring. This study showed that the eco-label knowledge played a main role in consumer preferences for certified wood products and suggested that different strategies should be considered in promoting FSC- and CEL-labeled wood products in the Chongqing market., China is the world's largest wood flooring market. In 2017, the country's production and consumption of wood flooring both exceeded 500 million square meters (State Forestry Administration of China 2018). [...]

Published
2019
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10. Two Distinct Amyloid β-Protein (Aβ) Assembly Pathways Leading to Oligomers and Fibrils Identified by Combined Fluorescence Correlation Spectroscopy, Morphology, and Toxicity Analyses*

Author

Matsumura, Satoko, Shinoda, Keiko, Yamada, Mayumi, Yokojima, Satoshi, Inoue, Masafumi, Ohnishi, Takayuki, Shimada, Tetsuya, Kikuchi, Kazuya, Masui, Dai, Hashimoto, Shigeki, Sato, Michio, Ito, Akane, Akioka, Manami, Takagi, Shinsuke, Nakamura, Yoshihiro, Nemoto, Kiyokazu, Hasegawa, Yutaka, Takamoto, Hisayoshi, Inoue, Haruo, Nakamura, Shinichiro, Nabeshima, Yo-ichi, Teplow, David B, Kinjo, Masataka, and Hoshi, Minako

Subjects
Brain Disorders, Dementia, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative, Alzheimer's Disease, Aging, Aetiology, 2.1 Biological and endogenous factors, Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Animals, Cells, Cultured, Humans, Peptides, Protein Multimerization, Rats, Chemical Sciences, Biological Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology
Abstract

Nonfibrillar assemblies of amyloid β-protein (Aβ) are considered to play primary roles in Alzheimer disease (AD). Elucidating the assembly pathways of these specific aggregates is essential for understanding disease pathogenesis and developing knowledge-based therapies. However, these assemblies cannot be monitored in vivo, and there has been no reliable in vitro monitoring method at low protein concentration. We have developed a highly sensitive in vitro monitoring method using fluorescence correlation spectroscopy (FCS) combined with transmission electron microscopy (TEM) and toxicity assays. Using Aβ labeled at the N terminus or Lys(16), we uncovered two distinct assembly pathways. One leads to highly toxic 10-15-nm spherical Aβ assemblies, termed amylospheroids (ASPDs). The other leads to fibrils. The first step in ASPD formation is trimerization. ASPDs of ∼330 kDa in mass form from these trimers after 5 h of slow rotation. Up to at least 24 h, ASPDs remain the dominant structures in assembly reactions. Neurotoxicity studies reveal that the most toxic ASPDs are ∼128 kDa (∼32-mers). In contrast, fibrillogenesis begins with dimer formation and then proceeds to formation of 15-40-nm spherical intermediates, from which fibrils originate after 15 h. Unlike ASPD formation, the Lys(16)-labeled peptide disturbed fibril formation because the Aβ(16-20) region is critical for this final step. These differences in the assembly pathways clearly indicated that ASPDs are not fibril precursors. The method we have developed should facilitate identifying Aβ assembly steps at which inhibition may be beneficial.

Published
2011

11. Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses.

Author

Matsumura, Satoko, Shinoda, Keiko, Yamada, Mayumi, Yokojima, Satoshi, Inoue, Masafumi, Ohnishi, Takayuki, Shimada, Tetsuya, Kikuchi, Kazuya, Masui, Dai, Hashimoto, Shigeki, Sato, Michio, Ito, Akane, Akioka, Manami, Takagi, Shinsuke, Nakamura, Yoshihiro, Nemoto, Kiyokazu, Hasegawa, Yutaka, Takamoto, Hisayoshi, Inoue, Haruo, Nakamura, Shinichiro, Nabeshima, Yo-ichi, Teplow, David B, Kinjo, Masataka, and Hoshi, Minako

Subjects
Cells, Cultured, Animals, Humans, Rats, Alzheimer Disease, Amyloid, Peptides, Protein Multimerization, Amyloid beta-Peptides, Cells, Cultured, Biochemistry & Molecular Biology, Biological Sciences, Medical and Health Sciences, Chemical Sciences
Abstract

Nonfibrillar assemblies of amyloid β-protein (Aβ) are considered to play primary roles in Alzheimer disease (AD). Elucidating the assembly pathways of these specific aggregates is essential for understanding disease pathogenesis and developing knowledge-based therapies. However, these assemblies cannot be monitored in vivo, and there has been no reliable in vitro monitoring method at low protein concentration. We have developed a highly sensitive in vitro monitoring method using fluorescence correlation spectroscopy (FCS) combined with transmission electron microscopy (TEM) and toxicity assays. Using Aβ labeled at the N terminus or Lys(16), we uncovered two distinct assembly pathways. One leads to highly toxic 10-15-nm spherical Aβ assemblies, termed amylospheroids (ASPDs). The other leads to fibrils. The first step in ASPD formation is trimerization. ASPDs of ∼330 kDa in mass form from these trimers after 5 h of slow rotation. Up to at least 24 h, ASPDs remain the dominant structures in assembly reactions. Neurotoxicity studies reveal that the most toxic ASPDs are ∼128 kDa (∼32-mers). In contrast, fibrillogenesis begins with dimer formation and then proceeds to formation of 15-40-nm spherical intermediates, from which fibrils originate after 15 h. Unlike ASPD formation, the Lys(16)-labeled peptide disturbed fibril formation because the Aβ(16-20) region is critical for this final step. These differences in the assembly pathways clearly indicated that ASPDs are not fibril precursors. The method we have developed should facilitate identifying Aβ assembly steps at which inhibition may be beneficial.

Published
2011

12. Current prognostic factors of advanced gastric cancer patients treated with chemotherapy: real world data from a Japanese 12 institutions

Author

Yamamoto, Shumpei, primary, Kanzaki, Hiromitsu, additional, Sakaguchi, Chihiro, additional, Mouri, Hirokazu, additional, Tsuzuki, Takao, additional, Nasu, Junichiro, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Obayashi, Yuka, additional, Inoue, Masafumi, additional, Kato, Ryo, additional, Matsubara, Minoru, additional, Kita, Masahide, additional, and Okada, Hiroyuki, additional

Published
2023
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14. Registry Report of Initial 50 Cases at Fukuoka University Lung Transplant Program

Author

Miyahara, So, Waseda, Ryuichi, Nishino, Nanako, Midorikawa, Kensuke, Abe, Sosei, Iwanaka, Tsuyoshi, Ueda, Yuichiro, Moroga, Toshihiko, Iwashita, Kohei, Shigematsu, Kenji, Akiyoshi, Kozaburo, Hayashida, Yoshio, Minematsu, Noritoshi, Wada, Hideichi, Hirano, Ryosuke, Fujita, Masaki, Kushima, Hisako, Ishi, Hiroshi, Inoue, Masafumi, Nishimura, Shigenori, Iwaki, Rie, Hiratsuka, Masafumi, Toubou, Etsuko, Sato, Toshihiko, and Shiraishi, Takeshi

Subjects
waitlist mortality, lung transplantation candidate, living-donor lobar lung transplantation, cadaveric lung transplantation
Published
2022

17. Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Miyahara, Koji, Nakagawa, Masahiro, Mouri, Hirokazu, Mizuno, Motowo, Takahashi, Sakuma, Hori, Shinichiro, Nasu, Junichiro, Tsuzuki, Takao, Miyaike, Jiro, Takenaka, Ryuta, Yamauchi, Kenji, Kobayashi, Sayo, Toyokawa, Tatsuya, Inoue, Masafumi, Nishimura, Mamoru, Matsubara, Minoru, Tomoda, Jun, Yamasaki, Yasushi, Tanaka, Takehiro, Shirakawa, Yasuhiro, Kawahara, Yoshiro, Fujiwara, Toshiyoshi, Okada, Hiroyuki, and Okayama Gut Study Group

Subjects
Barrett's adenocarcinoma, lesion, surgery, Barrett Esophagus, endoscopic resection, Esophageal Neoplasms, Japan, short -segment Barrett's esophagus, metachronous, Humans, Adenocarcinoma, Retrospective Studies, long -segment Barrett's esophagus
Abstract

Objective Although Barrett's adenocarcinoma (BA) remains a minor disease in Japan, its incidence has been gradually increasing. We analyzed the characteristics of BA in Japanese populations. Methods We retrospectively reviewed medical records and analyzed the clinicopathological differences between short-segment Barrett's esophagus (SSBE) and long-segment Barrett's esophagus (LSBE), as well as metastasis. Local recurrence and metachronous lesions were analyzed only in patients who underwent endoscopic resection (ER). Patients Consecutive patients who had pathological T1 BAs resected by ER or surgery from January 2003 Results A total of 168 patients were analyzed, including 139 with SSBE and 29 with LSBE. In total, 67% of the SSBE lesions and 32% of the LSBE lesions were located between 0 and 3 o'clock (p=0.0014). No patients who achieved pathological margin-free resection (pR0) and 17% of patients who did not achieve pR0 experienced local recurrence (p=0.0131). None of the patients without lymphovascular involvement, a poorly differentiated component, lesion size of >30 mm, and submucosal invasion of >500 mu m experienced metastasis. The 5-year cumulative incidence rate of metachronous BA after ER was 0% in patients with SSBE and 40% in patients with LSBE (p=0.0005). Conclusion Superficial BA was likely to be detected at the right anterior wall of SSBE in the Japanese population. The risk for metachronous BA after ER was high in Japanese patients with LSBE, as in Western patients.

Published
2022

21. Partial splenic artery embolization is effective for bleeding gastric varices due to sinistral portal hypertension associated with pancreatic tail cancer

Author

TSUTSUI, Tomoaki, primary, HARADA, Ryo, additional, AKIMOTO, Yutaka, additional, OKI, Kentaro, additional, YOSHIKAWA, Tomoki, additional, YASUI, Toshihiro, additional, AKITA, Mitsuhiro, additional, TOSHIMORI, Junichi, additional, INOUE, Masafumi, additional, and KOBASHI, Haruhiko, additional

Published
2022
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24. Gastrointestinal stromal tumors in the duodenum show increased contrast enhancement compared with those in the stomach on computed tomography

Author

Sato, Ryosuke, primary, Harada, Ryo, additional, Hashimoto, Kenji, additional, Tsutsui, Tomoaki, additional, Hattori, Nao , additional, Inoue, Masafumi, additional, Kobashi, Haruhiko, additional, Morimoto, Mami, additional, Tamura, Maiko, additional, Hayashi, Atsushi, additional, and Iwamuro, Masaya, additional

Published
2022
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31. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort

Author

Naitoh, Itaru, primary, Kamisawa, Terumi, additional, Tanaka, Atsushi, additional, Nakazawa, Takahiro, additional, Kubota, Kensuke, additional, Takikawa, Hajime, additional, Unno, Michiaki, additional, Masamune, Atsushi, additional, Kawa, Shigeyuki, additional, Nakamura, Seiji, additional, Okazaki, Kazuichi, additional, Furumatsu, Keisuke, additional, Sawai, Shigeaki, additional, Goto, Takuma, additional, Okumura, Toshikatsu, additional, Suzuki, Daisuke, additional, Otsuka, Masayuki, additional, Kobori, Ikuhiro, additional, Tamano, Masaya, additional, Koizumi, Mitsuhito, additional, Hiasa, Yoichi, additional, Kawabe, Naoto, additional, Hirooka, Yoshiki, additional, Yamamoto, Satoshi, additional, Asano, Yukio, additional, Inui, Kazuo, additional, Horiguchi, Akihiko, additional, Watanabe, Hiroyuki, additional, Toya, Daishu, additional, Hatayama, Katsuko, additional, Ueki, Toshiharu, additional, Kinoshita, Norikatsu, additional, Sugimoto, Mitsuru, additional, Ohira, Hiromasa, additional, Mukai, Tsuyoshi, additional, Tomita, Eiichi, additional, Iwata, Keisuke, additional, Shimizu, Shogo, additional, Suetsugu, Jun, additional, Shimizu, Masahito, additional, Tsuji, Keiji, additional, Ishida, Ryoko, additional, Ito, Masanori, additional, Furukawa, Ryutaro, additional, Sakamoto, Naoya, additional, Araki, Masahiro, additional, Tanno, Satoshi, additional, Sakamoto, Yasunari, additional, Ito, Tetsuhide, additional, Takai, Satoshi, additional, Ikeya, Shinichi, additional, Yamada, Takanori, additional, Kudara, Norihiko, additional, Shimizu, Akinori, additional, Hanada, Keiji, additional, Ichiki, Yasunori, additional, Kitada, Hideki, additional, Hifumi, Michio, additional, Kimura, Hiroyuki, additional, Kurosaki, Masayuki, additional, Izumi, Namiki, additional, Sumi, Hajime, additional, Haruta, Jun-ichi, additional, Hayashi, Katsumi, additional, Harada, Ryo, additional, Inoue, Masafumi, additional, Nakamura, Shinichiro, additional, Ito, Tetsuya, additional, Tomishima, Ko, additional, Isayama, Hiroyuki, additional, Oura, Kyoko, additional, Masaki, Tsutomu, additional, Shimokawahara, Naoto, additional, Tanoue, Shirou, additional, Maemura, Kousei, additional, Ido, Akio, additional, Mizushima, Ichiro, additional, Kawano, Mitsuhiro, additional, Yoshida, Katsunori, additional, Naganuma, Makoto, additional, Murata, Miki, additional, Nishio, Akiyoshi, additional, Fujita, Yuji, additional, Teratani, Takuma, additional, Matsubara, Shohei, additional, Tamai, Hironao, additional, Yoshida, Yuu, additional, Azemoto, Ryousaku, additional, Kamata, Ken, additional, Watanabe, Tomohiro, additional, Kurosu, Takahiro, additional, Koizumi, Wasaburou, additional, Fujita, Jun, additional, Seki, Hideyuki, additional, Ueda, Yasuhiro, additional, Fukumoto, Takumi, additional, Kousaki, Takuhiro, additional, Uchida, Kazushige, additional, Ochiai, Toshimasa, additional, Kawasaki, Takeshi, additional, Tanaka, Motohiko, additional, Ishida, Etsuji, additional, Notohara, Kenji, additional, Mori, Hideaki, additional, Mori, Toshiyuki, additional, Kawabata, Hideaki, additional, Miyata, Masatoshi, additional, Sakagami, Junichi, additional, Itoh, Yoshito, additional, Shiokawa, Masahiro, additional, Seno, Hiroshi, additional, Watanabe, Noriko, additional, Naitoh, Itaru, additional, Kataoka, Hiromi, additional, Aoki, Toshinori, additional, Fujishiro, Mitsuhiro, additional, Niihara, Toru, additional, Nishimata, Hiroto, additional, Mitoro, Akira, additional, Yoshiji, Hitoshi, additional, Yoshida, Motoyuki, additional, Ikeda, Masafumi, additional, Tomita, Kengo, additional, Hokari, Ryota, additional, Hayasaka, Kenji, additional, Amano, Yuji, additional, Shioji, Kazuhiko, additional, Hayashi, Kazunao, additional, Terai, Shuji, additional, Nakajima, Michiko, additional, Yamahana, Junya, additional, Matsumoto, Ryusuke, additional, Kikuchi, Hideaki, additional, Kanamori, Akira, additional, Kiriyama, Seiki, additional, Iwatsu, Shinichi, additional, Kato, Yuji, additional, Horiguchi, Shigeru, additional, Yagi, Takahito, additional, Okada, Hiroyuki, additional, Ohkawa, Kazuyoshi, additional, Hirao, Motohiro, additional, Hiramatsu, Naoki, additional, Oza, Noriko, additional, Imamura, Haruo, additional, Baba, Takeshi, additional, Nakano, Shigeru, additional, Shinobi, Tetsuya, additional, Ryozawa, Shomei, additional, Motoya, Masayo, additional, Nakase, Hiroshi, additional, Kinoshita, Noboru, additional, Ito, Kei, additional, Miyake, Tatsuya, additional, Kohge, Naruaki, additional, Tobita, Hiroshi, additional, Joshita, Satoru, additional, Umemura, Takeji, additional, Kawaguchi, Shinya, additional, Ohno, Kazuya, additional, Sonobe, Koichi, additional, Satoh, Akihiko, additional, Shimosegawa, Tooru, additional, Miura, Fumihiko, additional, Yagi, Minami, additional, Sano, Keiji, additional, Kin, Toshifumi, additional, Katanuma, Akio, additional, Koike, Kazuhiko, additional, Miura, Shin, additional, Kawashima, Youhei, additional, Kagawa, Tatehiro, additional, Azuma, Seishin, additional, Watanabe, Mamoru, additional, Honjyo, Mitsuyoshi, additional, Itoi, Takao, additional, Honda, Akira, additional, Kobayashi, Katsumasa, additional, Asano, Toru, additional, Mizuno, Suguru, additional, Nishino, Takayoshi, additional, Taniguchi, Hideaki, additional, Tajiri, Kazuto, additional, Yasuda, Ichiro, additional, Tanaka, Yoshiya, additional, Oe, Shinji, additional, Harada, Masaru, additional, Kurata, Masanao, additional, Fukasawa, Mituharu, additional, Enomoto, Nobuyuki, additional, Kawaji, Yuki, additional, Kitano, Masayuki, additional, Nishise, Yuko, additional, Hirakawa, Hidetoshi, additional, Ishizawa, Tetsuya, additional, Ueno, Yoshiyuki, additional, Kaino, Miyuki, additional, Fujimoto, Yuko, additional, and Sakaida, Isao, additional

Published
2021
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37. Emergence of oseltamivir-resistant pandemic (H1N1) 2009 virus within 48 hours

Author

Inoue, Masafumi, Barkham, Timothy, Leo, Yee-Sin, Chan, Kwai-Peng, Chow, Angela, Wong, Christopher W., Lee, Raphael Tze-Chuen, Maurer-Stroh, Sebastian, Lin, Raymond, and Lin, Cui

Subjects
Oseltamivir phosphate -- Health aspects -- Research, Swine influenza -- Research -- Drug therapy -- Health aspects, Drug resistance -- Research -- Drug therapy -- Health aspects, Health
Abstract

Early descriptions of emergence of H275Y mutants in pandemic (H1N1) 2009 virus showed resistance after 11 and 23 days of therapy in immunosuppressed patients (1). Also in previous reports, transmission [...]

Published
2010
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43. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Inoue, Masafumi, Ishiyama , Shuhei, Yamauchi, Kenji, Miyahara, Koji, Toyokawa, Tatsuya, Tsuzuki, Takao, Miyaike, Jiro, Matsubara, Minoru, Takahashi, Sakuma, Nishimura, Mamoru, Takenaka, Ryuta, Yunoki, Naoko, Hori, Shinichiro, Kobayashi, Sayo, Yamasaki, Yasushi, Kawahara, Yoshiro, Ishikawa, Hideki, Okada, Hiroyuki, Hamada, Kenta, Kanzaki, Hiromitsu, Inoue, Masafumi, Ishiyama , Shuhei, Yamauchi, Kenji, Miyahara, Koji, Toyokawa, Tatsuya, Tsuzuki, Takao, Miyaike, Jiro, Matsubara, Minoru, Takahashi, Sakuma, Nishimura, Mamoru, Takenaka, Ryuta, Yunoki, Naoko, Hori, Shinichiro, Kobayashi, Sayo, Yamasaki, Yasushi, Kawahara, Yoshiro, Ishikawa, Hideki, and Okada, Hiroyuki

Abstract

Objective Gastric endoscopic submucosal dissection (ESD) under heparin replacement (HR) of warfarin reportedly has a high risk of delayed bleeding (24-57%). It is possible that the delayed bleeding risk may have changed over the years. We evaluated the current risk of delayed bleeding after gastric ESD under HR of anticoagulant agents. Methods We retrospectively reviewed the delayed bleeding rate and analyzed the risk factors for delayed bleeding. Patients Consecutive patients who underwent gastric ESD under HR of anticoagulant agents from July 2015 to June 2017. Results A total of 32 patients with a solitary early gastric cancer and taking anticoagulant agents were analyzed, including 24 patients on warfarin (the warfarin group) and 8 patients on direct oral anticoagulants (the DOAC group). Three (9.4%) patients experienced delayed bleeding: three (12.5%) patients in the warfarin group and no patients in the DOAC group. Continued aspirin treatment was identified to be a risk factor of delayed bleeding (p=0.01). Conclusion Careful management may be required for patients undergoing gastric ESD under continued aspirin treatment in addition to HR of anticoagulant agents; although the delayed bleeding risk after gastric ESD under HR of anticoagulant agents might have decreased over the years.

Published
2020

47. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, primary, Kanzaki, Hiromitsu, additional, Inoue, Masafumi, additional, Ishiyama, Shuhei, additional, Yamauchi, Kenji, additional, Miyahara, Koji, additional, Toyokawa, Tatsuya, additional, Tsuzuki, Takao, additional, Miyaike, Jiro, additional, Matsubara, Minoru, additional, Takahashi, Sakuma, additional, Nishimura, Mamoru, additional, Takenaka, Ryuta, additional, Yunoki, Naoko, additional, Hori, Shinichiro, additional, Kobayashi, Sayo, additional, Yamasaki, Yasushi, additional, Kawahara, Yoshiro, additional, Ishikawa, Hideki, additional, and Okada, Hiroyuki, additional

Published
2020
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