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Your search keyword '"Inoue, Futaba"' showing total 13 results
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13 results on '"Inoue, Futaba"'

1. Development of a deep learning method for improving diagnostic accuracy for uterine sarcoma cases

Author

Toyohara, Yusuke, Sone, Kenbun, Noda, Katsuhiko, Yoshida, Kaname, Kurokawa, Ryo, Tanishima, Tomoya, Kato, Shimpei, Inui, Shohei, Nakai, Yudai, Ishida, Masanori, Gonoi, Wataru, Tanimoto, Saki, Takahashi, Yu, Inoue, Futaba, Kukita, Asako, Kawata, Yoshiko, Taguchi, Ayumi, Furusawa, Akiko, Miyamoto, Yuichiro, Tsukazaki, Takehiro, Tanikawa, Michihiro, Iriyama, Takayuki, Mori-Uchino, Mayuyo, Tsuruga, Tetsushi, Oda, Katsutoshi, Yasugi, Toshiharu, Takechi, Kimihiro, Abe, Osamu, and Osuga, Yutaka

Published
2022
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2. Synthetic lethality from the combination of a histone methyltransferase, SUV39H2 inhibitor and a poly (ADP-ribose) polymerase inhibitor for uterine leiomyosarcoma

Author

Toyohara, Yusuke, primary, Sone, Kenbun, additional, Kumegawa, Kohei, additional, Yamamoto, Yoko, additional, Hachijo, Ryuta, additional, Tanimoto, Saki, additional, INOUE, FUTABA, additional, Kukita, Asako, additional, Taguchi, Ayumi, additional, Ikemura, Masako, additional, Miyamoto, Yuichiro, additional, Tanikawa, Michihiro, additional, Iriyama, Takayuki, additional, MORI-UCHINO, Mayuyo, additional, Hamamoto, Ryuji, additional, Ushiku, Tetsuo, additional, Oda, Katsutoshi, additional, HIROTA, Yasushi, additional, Maruyama, Reo, additional, and Osuga, Yutaka, additional

Published
2024
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3. Inhibition of protein arginine methyltransferase 6 activates interferon signaling and induces the apoptosis of endometrial cancer cells via histone modification

Author

Inoue, Futaba, primary, Sone, Kenbun, additional, Kumegawa, Kohei, additional, Hachijo, Ryuta, additional, Suzuki, Eri, additional, Tanimoto, Saki, additional, Tsuboyama, Natsumi, additional, Kato, Kosuke, additional, Toyohara, Yusuke, additional, Takahashi, Yu, additional, Kusakabe, Misako, additional, Kukita, Asako, additional, Honjoh, Harunori, additional, Nishijima, Akira, additional, Taguchi, Ayumi, additional, Miyamoto, Yuichiro, additional, Tanikawa, Michihiro, additional, Iriyama, Takayuki, additional, Mori, Mayuyo, additional, WADA‑HIRAIKE, Osamu, additional, Oda, Katsutoshi, additional, Suzuki, Hiromu, additional, Maruyama, Reo, additional, and Osuga, Yutaka, additional

Published
2024
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4. The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells

Author

Kukita, Asako, primary, Sone, Kenbun, additional, Kaneko, Syuzo, additional, Kawakami, Eiryo, additional, Oki, Shinya, additional, Kojima, Machiko, additional, Wada, Miku, additional, Toyohara, Yusuke, additional, Takahashi, Yu, additional, Inoue, Futaba, additional, Tanimoto, Saki, additional, Taguchi, Ayumi, additional, Fukuda, Tomohiko, additional, Miyamoto, Yuichiro, additional, Tanikawa, Michihiro, additional, Mori-Uchino, Mayuyo, additional, Tsuruga, Tetsushi, additional, Iriyama, Takayuki, additional, Matsumoto, Yoko, additional, Nagasaka, Kazunori, additional, Wada-Hiraike, Osamu, additional, Oda, Katsutoshi, additional, Hamamoto, Ryuji, additional, and Osuga, Yutaka, additional

Published
2022
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6. A case of difficult‐to‐diagnose non‐invasive papillary squamous cell carcinoma of the uterine cervix infected with human papilloma virus 6: A diagnostic pitfall

Author

Sone, Kenbun, primary, Inoue, Futaba, additional, Taguchi, Ayumi, additional, Hinata, Munetoshi, additional, Ikemura, Masako, additional, Miyamoto, Yuichiro, additional, Michihiro, Tanikawa, additional, Ohno, Tamami, additional, Iriyama, Takayuki, additional, Mori‐Uchino, Mayuyo, additional, Tsuruga, Tetsushi, additional, Mishima, Misako, additional, and Osuga, Yutaka, additional

Published
2021
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7. Automated system for diagnosing endometrial cancer by adopting deep-learning technology in hysteroscopy

Author

Takahashi, Yu, primary, Sone, Kenbun, additional, Noda, Katsuhiko, additional, Yoshida, Kaname, additional, Toyohara, Yusuke, additional, Kato, Kosuke, additional, Inoue, Futaba, additional, Kukita, Asako, additional, Taguchi, Ayumi, additional, Nishida, Haruka, additional, Miyamoto, Yuichiro, additional, Tanikawa, Michihiro, additional, Tsuruga, Tetsushi, additional, Iriyama, Takayuki, additional, Nagasaka, Kazunori, additional, Matsumoto, Yoko, additional, Hirota, Yasushi, additional, Hiraike-Wada, Osamu, additional, Oda, Katsutoshi, additional, Maruyama, Masanori, additional, Osuga, Yutaka, additional, and Fujii, Tomoyuki, additional

Published
2021
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9. Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer

Author

Wada, Miku, primary, Kukita, Asako, additional, Sone, Kenbun, additional, Hamamoto, Ryuji, additional, Kaneko, Syuzo, additional, Komatsu, Masaaki, additional, Takahashi, Yu, additional, Inoue, Futaba, additional, Kojima, Machiko, additional, Honjoh, Harunori, additional, Taguchi, Ayumi, additional, Kashiyama, Tomoko, additional, Miyamoto, Yuichiro, additional, Tanikawa, Michihiro, additional, Tsuruga, Tetsushi, additional, Mori-Uchino, Mayuyo, additional, Wada-Hiraike, Osamu, additional, Osuga, Yutaka, additional, and Fujii, Tomoyuki, additional

Published
2020
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10. Usefulness of biopsy by office hysteroscopy for endometrial cancer: A case report

Author

Sone, Kenbun, primary, Eguchi, Satoko, additional, Asada, Kayo, additional, Inoue, Futaba, additional, Miyamoto, Yuichiro, additional, Tanikawa, Michihiro, additional, Tsuruga, Tetsushi, additional, Mori‑Uchino, Mayuyo, additional, Matsumoto, Yoko, additional, Hiraike‑Wada, Osamu, additional, Oda, Katsutoshi, additional, Osuga, Yutaka, additional, and Fujii, Tomoyuki, additional

Published
2020
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13. BET inhibitor JQ1 induces apoptosis of ovarian and endometrial endometrioid carcinoma cells by downregulating c‑Myc .

Author

Tanimoto S, Sone K, Jonouchi Y, Hachijo R, Suzuki E, Tsuboyama N, Toyohara Y, Inoue F, Honjoh H, Fukuda T, Taguchi A, Miyamoto Y, Iriyama T, Mori M, Asada K, Komatsu M, Kaneko S, Hamamoto R, Wada-Hiraike O, Oda K, Hirota Y, and Osuga Y

Abstract

Although ovarian endometrioid carcinoma (OEC), frequently associated with endometrial endometrioid carcinoma (EEC), is often diagnosed at an early stage, the prognosis remains poor. The development of new, effective drugs to target these cancers is highly desirable. The bromodomain and extra-terminal domain (BET) family proteins serve a role in regulating transcription by recognizing histone acetylation, which is implicated in several types of cancer. BET inhibitors have been reported as promising cancer drugs. The present study aimed to assess the role of JQ1, a BET inhibitor, in ovarian and endometrial cancers. The sensitivity of OEC and EEC cell lines to JQ1 was assessed using cell viability and colony formation assays. Additionally, western blotting and cell cycle assays were performed to evaluate changes in c-Myc expression and apoptosis markers. Cell proliferation and colony formation assays revealed significant tumor suppression in both OEC and EEC cell lines in response to JQ1 treatment. Furthermore, treatment with JQ1 induced a decrease in c-Myc expression and an increase in apoptosis markers, such as cleaved PARP and the cell population in the sub-G1 phase, in both OEC and EEC cell lines. The findings of the present study indicate that JQ1 may induce cell death through c-Myc inhibition and could be a potentially novel therapeutic agent in the treatment in OEC and EEC. However, the direct mechanism, has not been fully elucidated, warranting further investigation., Competing Interests: KO was supported by grants from Daiichi Sankyo Co., Ltd. and AstraZeneca plc, and lecture fees from Chugai Pharmaceutical Co., Ltd. and AstraZeneca plc. All other authors declare that they have no competing interests., (Copyright: © 2024 Tanimoto et al.)

Published
2024
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