Disasters ar e serious events disturbing communities.1 In terms of medical aspects, these events cause numerous casualties and the high demand of medical care may require the enhancement of responders’ capacity for delivering timely and effective services.2,3 Individuals with chronic conditions require special attention in planning, response, and recovery phases after natural disasters, given their unique needs for medication, medical equipment and continuing healthcare, and potential exacerbation of their condition that require resource-intensive management.4 Natural disasters can impact the public health infrastructure and the social protection systems essential for vulnerable populations. Patients with non-communicable diseases e.g. respiratory and cardiovascular diseases, cancer and diabetes, are among vulnerable groups in critical conditions, who are highly affected by natural disasters.5 Non-Communicable diseases (NCDs) require an ongoing management for optimal outcomes, which is challenging in emergency settings, since natural disasters increase the risk of acute exacerbation in the health of people with NCDs and decrease the health systems responsiveness.6 NCD Management in emergencies requires the inclusion of non-communicable disease care into standard operating procedures, which would facilitate horizontal and vertical integration to other aspects of relief efforts.7,8 Patients with chronic illnesses including those with cardiovascular diseases, diabetes, cancers, and respiratory conditions are of the most vulnerable populations in disaster settings, who face various problems after natural disasters.9,10 By the collapse in some medical care systems and overloaded operating hospitals and other medical centers, provision of services to chronic patients seems to be a critical concern.11 Inadequately managed chronic illnesses can present a threat to life and well-being of the community in the immediate wake of these disasters, but their treatment traditionally has not been recognized as a public health or medical priority.12 Many patients did not have their medications or medical supplies, and too many did not know the names of their illnesses or medications or how to access the information.13 A critical problem in the resulting health crisis is the inability of the displaced population to manage their chronic diseases.14 The Center for Disease Control and Prevention (CDC) reported that NCDs accounted for five of the six most commonly reported conditions after Hurricane Katrina.15 This leads to indirect causes of mortality and more complications up to 70%-90%, primarily due to the deterioration of life-threatening conditions and exacerbation of chronic diseases.16 After natural disasters, inadequate care and resources, and lack of continuity of care for chronic diseases such as cardiovascular diseases, asthma, diabetes, renal diseases have led to exacerbation of symptoms associated with increased morbidity and mortality among this population.17 However, non-communicable diseases have received little attention from human-rights organizations during the acute phase of crises and emergencies, and there is a need to refocus on emergency disaster systems in the 21st Century.18 More than 45% of evacuees did not carry their daily medicines with them, meaning that over two third of total medicines provided during the disaster response were used to treat chronic diseases.19 Patients with chronic diseases face many challenges and have different needs during and after natural disasters and medical care must be continued during and after natural disasters. Statistics on different diseases reveal that at the time of natural disasters, there are an increased number of hospital admissions of patients with at least one chronic disease. As an example, in Sichuan earthquake, patients with hypertension and those with diabetes, constituted 47% and 24%, respectively, of city hospital admissions.20 Despite the significance and the critical impact of natural disasters on patients with non-communicable diseases and the exacerbation of their symptoms, there are not enough studies on the issue.21 Disaster and crisis manuals and guidelines mainly focus on communicable diseases like Aleppo boil, measles, cholera and diarrhea; and among available research literature, there is a limited number of studies on the management of non-communicable diseases in emergencies.22 Several studies have been conducted on the effects of natural disasters on non-communicable diseases reporting the exacerbation of clinical effects and insufficient medical facilities and equipment to care for patients. Therefore, this study aims to obtain a systematic review protocol for non-communicable diseases in the natural disasters.