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1. SARS-CoV-2 infection predisposes patients to coinfection with Staphylococcus aureus

Author

Ashira Lubkin, Lucie Bernard-Raichon, Ashley L. DuMont, Ana Mayela Valero Jimenez, Gregory G. Putzel, Juan Gago, Erin E. Zwack, Olufolakemi Olusanya, Kristina M. Boguslawski, Simone Dallari, Sophie Dyzenhaus, Christin Herrmann, Juliana K. Ilmain, Georgia L. Isom, Miranda Pawline, Andrew I. Perault, Sofya Perelman, William E. Sause, Ifrah Shahi, Amelia St. John, Rebecca Tierce, Xuhui Zheng, Chunyi Zhou, Maria G. Noval, Anna O'Keeffe, Magda Podkowik, Sandra Gonzales, Kenneth Inglima, Ludovic Desvignes, Sarah E. Hochman, Kenneth A. Stapleford, Lorna E. Thorpe, Alejandro Pironti, Bo Shopsin, Ken Cadwell, Meike Dittmann, and Victor J. Torres

Subjects
COVID, MRSA, coinfection, agr, SARS-CoV-2, Microbiology, QR1-502
Abstract

ABSTRACT Severe COVID-19 has been associated with coinfections with bacterial and fungal pathogens. Notably, patients with COVID-19 who develop Staphylococcus aureus bacteremia exhibit higher rates of mortality than those infected with either pathogen alone. To understand this clinical scenario, we collected and examined S. aureus blood and respiratory isolates from a hospital in New York City during the early phase of the pandemic from both SARS-CoV-2+ and SARS-CoV-2− patients. Whole genome sequencing of these S. aureus isolates revealed broad phylogenetic diversity in both patient groups, suggesting that SARS-CoV-2 coinfection was not associated with a particular S. aureus lineage. Phenotypic characterization of the contemporary collection of S. aureus isolates from SARS-CoV-2+ and SARS-CoV-2− patients revealed no notable differences in several virulence traits examined. However, we noted a trend toward overrepresentation of S. aureus bloodstream strains with low cytotoxicity in the SARS-CoV-2+ group. We observed that patients coinfected with SARS-CoV-2 and S. aureus were more likely to die during the acute phase of infection when the coinfecting S. aureus strain exhibited high or low cytotoxicity. To further investigate the relationship between SARS-CoV-2 and S. aureus infections, we developed a murine coinfection model. These studies revealed that infection with SARS-CoV-2 renders mice susceptible to subsequent superinfection with low cytotoxicity S. aureus. Thus, SARS-CoV-2 infection sensitizes the host to coinfections, including S. aureus isolates with low intrinsic virulence.IMPORTANCEThe COVID-19 pandemic has had an enormous impact on healthcare across the globe. Patients who were severely infected with SARS-CoV-2, the virus causing COVID-19, sometimes became infected with other pathogens, which is termed coinfection. If the coinfecting pathogen is the bacterium Staphylococcus aureus, there is an increased risk of patient death. We collected S. aureus strains that coinfected patients with SARS-CoV-2 to study the disease outcome caused by the interaction of these two important pathogens. We found that both in patients and in mice, coinfection with an S. aureus strain lacking toxicity resulted in more severe disease during the early phase of infection, compared with infection with either pathogen alone. Thus, SARS-CoV-2 infection can directly increase the severity of S. aureus infection.

Published
2024
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2. Antibiotic stewardship bundle for uncomplicated gram-negative bacteremia at an academic health system: a quasi-experimental study

Author

Juliana DiPietro, Yanina Dubrovskaya, Kassandra Marsh, Arnold Decano, John Papadopoulos, Dana Mazo, Kenneth Inglima, Vincent Major, Jonathon So, Samuel Yuditskiy, and Justin Siegfried

Subjects
Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract

Abstract Objective: To evaluate whether an antimicrobial stewardship bundle (ASB) can safely empower frontline providers in the treatment of gram-negative bloodstream infections (GN-BSI). Intervention and Method: From March 2021 to February 2022, we implemented an ASB intervention for GN-BSI in the electronic medical record (EMR) to guide clinicians at the point of care to optimize their own antibiotic decision-making. We conducted a before-and-after quasi-experimental pre-bundle (preBG) and post-bundle (postBG) study evaluating a composite of in-hospital mortality, infection-related readmission, GN-BSI recurrence, and bundle-related outcomes. Setting: New York University Langone Health (NYULH), Tisch/Kimmel (T/K) and Brooklyn (BK) campuses, in New York City, New York. Patients: Out of 1097 patients screened, the study included 225 adults aged ≥18 years (101 preBG vs 124 postBG) admitted with at least one positive blood culture with a monomicrobial gram-negative organism. Results: There was no difference in the primary composite outcome (12.9% preBG vs. 7.3% postBG; P = 0.159) nor its individual components of in-hospital mortality, 30-day infection-related readmission, and GN-BSI recurrence. Vancomycin (VAN) discontinuation (DC) was done more frequently by the primary team in postBG (37.9% vs 66.7%; P < 0.001). In postBG, de-escalation done by the primary team increased by 8.8%, P = 0.310 and there was an 11.1% increase in the use of aminopenicillin-based antibiotics, P = 0.043. Conclusions: GN-BSI bundle worked as a nudge-based strategy to guide providers in VAN DC and increased de-escalation to aminopenicillin-based antibiotics without negatively impacting patient outcomes.

Published
2024
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3. The Hoya The Hoya The Hoya What's Wrong with 'What's Wrong With New York?' Nothing, as Far as I Can Tell

Author

Inglima, Paulina

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima content'],'key':'location'}],'devices':['desktop'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.85,'max':5,'lazyMax':94,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Content'],'key':'location'}],'devices':['tablet'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.7,'max':6,'lazyMax':93,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > 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Published
2024

4. Non-commutative waves for gravitational anyons

Author

Inglima, Sergio and Schroers, Bernd

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology, Mathematical Physics
Abstract

We revisit the representation theory of the quantum double of the universal cover of the Lorentz group in 2+1 dimensions, motivated by its role as a deformed Poincar\'e symmetry and symmetry algebra in (2+1)-dimensional quantum gravity. We express the unitary irreducible representations in terms of covariant, infinite-component fields on curved momentum space satisfying algebraic spin and mass constraints. Adapting and applying the method of group Fourier transforms, we obtain covariant fields on (2+1)-dimensional Minkowski space which necessarily depend on an additional internal and circular dimension. The momentum space constraints turn into differential or exponentiated differential operators, and the group Fourier transform induces a star product on Minkowski space and the internal space which is essentially a version of Rieffel's deformation quantisation via convolution., Comment: 36 pages, 2 figures; minor corrections and additional references (version to appear in Letters in Mathematical Physics)

Published
2018
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5. The Hoya The Hoya The Hoya DC Moves Closer to Ending Legacy Admissions After GU Student Activism

Author

Inglima, Paulina

Subjects
College admissions, News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima content'],'key':'location'}],'devices':['desktop'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.85,'max':5,'lazyMax':94,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Content'],'key':'location'}],'devices':['tablet'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.7,'max':6,'lazyMax':93,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > 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Published
2024

6. The Hoya The Hoya The Hoya Georgetown Community Raises Concerns, Solutions Through Transportation Study

Author

Inglima, Jasmine ZhangPaulina

Subjects
Transportation, Transportation industry, News, opinion and commentary, Sports and fitness
Abstract

Byline: Jasmine ZhangPaulina Inglima content'],'key':'location'}],'devices':['desktop'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.85,'max':5,'lazyMax':94,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Content'],'key':'location'}],'devices':['tablet'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.7,'max':6,'lazyMax':93,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > 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Published
2024

7. The Hoya The Hoya The Hoya Lawmakers Propose Solutions Amid Citywide Soar in Truancy

Author

Inglima, Paulina

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima content'],'key':'location'}],'devices':['desktop'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.85,'max':5,'lazyMax':94,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Content'],'key':'location'}],'devices':['tablet'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.7,'max':6,'lazyMax':93,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > 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.entry-content > p, .sno-story-container > p, #sno-story-body-content > [...]

Published
2024

8. The Hoya The Hoya The Hoya Georgetown Community Raises Concerns and Solutions Through Transportation Study

Author

Inglima, Jasmine ZhangPaulina

Subjects
Transportation, Transportation industry, News, opinion and commentary, Sports and fitness
Abstract

Byline: Jasmine ZhangPaulina Inglima content'],'key':'location'}],'devices':['desktop'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.85,'max':5,'lazyMax':94,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Content'],'key':'location'}],'devices':['tablet'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.7,'max':6,'lazyMax':93,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Content'],'key':'location'}],'devices':['phone'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.85,'max':5,'lazyMax':94,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Below 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Published
2024

9. The Hoya The Hoya The Hoya Library of Congress 'Live! at the Library' Shines Light on Black Women in Historical Fiction

Author

Inglima, Paulina

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima content'],'key':'location'}],'devices':['desktop'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.85,'max':5,'lazyMax':94,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Content'],'key':'location'}],'devices':['tablet'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.7,'max':6,'lazyMax':93,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > 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Published
2024

10. The Hoya The Hoya The Hoya Smithsonian Institute Commits to Repatriation of Human Remains in New Report

Author

Inglima, Caroline WoodwardPaulina

Subjects
Indigenous peoples -- Reports, News, opinion and commentary, Sports and fitness
Abstract

Byline: Caroline WoodwardPaulina Inglima content'],'key':'location'}],'devices':['desktop'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.85,'max':5,'lazyMax':94,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Content'],'key':'location'}],'devices':['tablet'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.7,'max':6,'lazyMax':93,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Content'],'key':'location'}],'devices':['phone'],'name':'Content','sticky':false,'location':'Content','dynamic':{'pageSelector':'','spacing':0.85,'max':5,'lazyMax':94,'enable':true,'lazy':true,'elementSelector':'.sno-story-container > p, #sno-story-body-content > p','skip':5,'classNames':[],'position':'afterend','every':1,'enabled':true},'stickyOverlapSelector':'','adSizes':[[728,90],[336,280],[320,50],[468,60],[970,90],[250,250],[1,1],[320,100],[970,250],[1,2],[300,50],[300,300],[552,334],[728,250],[300,250]],'priority':199,'autosize':true},{'sequence':null,'targeting':[{'value':['Below 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.entry-content > p, .sno-story-container > p, #sno-story-body-content [...]

Published
2024

12. Evaluation of a Multiplex PCR Panel for the Microbiological Diagnosis of Pneumonia in Hospitalized Patients: Experience from an Academic Medical Center

Author

Ioannis M. Zacharioudakis, Fainareti N. Zervou, Yanina Dubrovskaya, Kenneth Inglima, Benjamin See, and Maria Aguero-Rosenfeld

Subjects
Pneumonia, Multiplex PCR assays, Diagnostic stewardship, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: We evaluated the value of BioFire® FilmArray® pneumonia panel in establishing a microbiological diagnosis of pneumonia. We evaluated opportunities for antimicrobial optimization from its use. Methods: We included adult patients with pneumonia between May 2019 and January 2020. The pneumonia panel was used on high-quality sputum specimens, and the results were prospectively compared with sputum cultures and other tests performed according to standard of care. Results: Seventy patients were included, sixty-nine of whom completed a 5-day antimicrobial course for pneumonia, and 14.3% died during hospitalization. There was a trend of higher rate of microbiological diagnosis among the patients with culture submitted before antimicrobial administration (9/15 vs. 20/55; p = 0.09). The panel increased the microbiological diagnosis from 29/70 to 59/70 (p < 0.001) patients. The per isolate analysis revealed an increase in the isolation of Haemophilus influenzae (p = 0.002) and Streptococcus pneumoniae (p = 0.05). On review of empiric antimicrobials, there was potential for antimicrobial optimization in 56/70 patients, including 9 bacteria among 9 patients, which were not covered by empiric treatment and another 70 antimicrobials in 49 patients that could have been stopped. Conclusions: Incorporation of the pneumonia panel in the diagnostic work-up of pneumonia substantially increased the rate of microbiological diagnosis and revealed abundant opportunities for antimicrobial optimization.

Published
2021
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13. Cross-sectional study on health professionals' perception of effectiveness in conducting cardiopulmonary resuscitation on adults.

Author

Gavetti, Dario, Barbero, Roberta, Diciotto, Gennaro, Giglio, Angelo, Inglima Modica, Daniela, Andrada Nanescu, Eveline, Papotti, Grazia, and Tambone, Sara

Subjects
CURRICULUM, CROSS-sectional method, TEAMS in the workplace, PROFESSIONAL practice, PROFESSIONAL ethics, OCCUPATIONAL roles, QUESTIONNAIRES, STATISTICAL sampling, WORK experience (Employment), ATTITUDES of medical personnel, LIFE support systems in critical care, CARDIOPULMONARY resuscitation
Abstract

Copyright of SCENARIO: Official Italian Journal of ANIARTI is the property of ANIARTI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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14. The Hoya The Hoya The Hoya Satirical Rendering of Ash Wednesday as 'Ass Wednesday' Draws Pushback

Author

Inglima, Paulina

Subjects
Worship programs, Christians, Wit and humor, News, opinion and commentary, Sports and fitness, Georgetown University
Abstract

Byline: Paulina Inglima content'class='sno-story-body-content sno-no-cap'> The Georgetown Heckler, a humor and satire magazine based at Georgetown University, has faced criticism after members drew butts on their foreheads in Red Square [...]

Published
2024

15. The Hoya The Hoya The Hoya D.C. City Council Advances Amended Sweeping Crime Bill

Author

Inglima, Paulina

Subjects
City councils, Crime, News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima content'class='sno-story-body-content sno-no-cap'> A sweeping yet controversial crime bill that seeks to crack down on crime in Washington, D.C. advanced upon its first reading at the D.C. Council [...]

Published
2024

16. ANC Updates: Licenses En Route for Hilltop Taproom, Dispensary

Author

Inglima, Paulina

Subjects
Medical marijuana -- Laws, regulations and rules, Marijuana industry -- Laws, regulations and rules, Government regulation, News, opinion and commentary, Sports and fitness, Georgetown University
Abstract

Byline: Paulina Inglima Georgetown's Advisory Neighborhood Commission 2E unanimously passed two resolutions at their Jan. 29 meeting. The resolutions will extend a stipulated liquor license for Hilltop Tap Room, a [...]

Published
2024

17. March for Life Highlights Spirited Campus Debate on Reproductive Rights

Author

Inglima, Paulina

Subjects
March for Life -- Demonstrations and protests, Abortion -- Political aspects -- Demonstrations and protests, News, opinion and commentary, Sports and fitness, Roe v. Wade 410 U.S. 113 (1973), Georgetown University -- Demonstrations and protests
Abstract

Byline: Paulina Inglima Georgetown University students and faculty joined protestors from around the country for the March For Life, which advocates for ending abortion in the United States, on Jan. [...]

Published
2024

18. New Academic Spaces to Open With Capitol Campus Expansion

Author

Inglima, Kate HwangPaulina

Subjects
Dwellings, Housing, Company pricing policy, News, opinion and commentary, Sports and fitness, Georgetown University
Abstract

Byline: Kate HwangPaulina Inglima Georgetown University is set to expand its Capitol Campus and enlarge its capacity for students to participate in its programs by acquiring an $89 million apartment [...]

Published
2024

19. Georgetown Community Remembers Professor John Hirsh

Author

Inglima, Paulina

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima Georgetown University students, faculty and alumni gathered at Dahlgren Chapel to celebrate the life of the late Professor John Campion Hirsh on Jan. 16. Hirsh, who taught [...]

Published
2024

21. Prompt dipole radiation in fusion reactions

Author

Martin, Brunella, Pierroutsakou, Dimitra, Agodi, Concetta, Alba, Rosa, Baran, Virgil, Boiano, Alfonso, Cardella, Giuseppe, Colonna, Maria, Coniglione, Rosa, De Filippo, Enrico, Del Zoppo, Antonio, Di Toro, Massimo, Inglima, Gianni, Glodariu, Tudor, La Commara, Marco, Maiolino, Concetta, Mazzocco, Marco, Pagano, Angelo, Piattelli, Paolo, Pirrone, Sara, Rizzo, Carmelo, Romoli, Mauro, Sandoli, Mario, Santonocito, Domenico, Sapienza, Piera, and Signorini, Cosimo

Subjects
Nuclear Experiment
Abstract

The prompt gamma ray emission was investigated in the 16A MeV energy region by means of the 36,40Ar+96,92Zr fusion reactions leading to a compound nucleus in the vicinity of 132Ce. We show that the prompt radiation, which appears to be still effective at such a high beam energy, has an angular distribution pattern consistent with a dipole oscillation along the symmetry axis of the dinuclear system. The data are compared with calculations based on a collective bremsstrahlung analysis of the reaction dynamics.

Published
2007
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22. DC Public Libraries Again Offer COVID-19 Tests

Author

Inglima, Paulina

Subjects
Public libraries, Vaccines, News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima The Georgetown Neighborhood Library, as well as other Washington, D.C. public libraries in all eight of the city's wards, are once again providing free COVID-19 tests as [...]

Published
2023

23. Department of Linguistics Separates from the Faculty of Languages and Linguistics

Author

Inglima, Paulina

Subjects
Natural language interfaces, Computational linguistics, Language processing, News, opinion and commentary, Sports and fitness, Georgetown University
Abstract

Byline: Paulina Inglima The department of linguistics separated from the Faculty of Languages and Linguistics at the beginning of the Fall 2023 semester, underscoring an important niche of the Georgetown [...]

Published
2023

24. Georgetown Appoints New Vice Provost For Research

Author

Inglima, Paulina

Subjects
College administrators -- Appointments, resignations and dismissals, News, opinion and commentary, Sports and fitness, Georgetown University
Abstract

Byline: Paulina Inglima Georgetown University announced physics professor Jeffrey Urbach as its new vice provost Nov. 3. Urbach is currently an interdisciplinary chair in science alongside his role in the [...]

Published
2023

25. Georgetown College Appoints New Vice Provost For Research

Author

Inglima, Paulina

Subjects
College administrators -- Appointments, resignations and dismissals, News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima The Georgetown University College of Arts and Sciences announced physics professor Jeffrey Urbach as its new vice provost Nov. 3. Urbach is currently an interdisciplinary chair in [...]

Published
2023

26. Students, Neighborhood Residents Raise Public Safety Concerns at ANC Meeting

Author

Inglima, Paulina

Subjects
Police administration -- Conferences, meetings and seminars, College students -- Conferences, meetings and seminars, News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima Georgetown University students and community residents expressed concerns about a recent increase in criminal and dangerous activity at an Oct. 30 Advisory Neighborhood Commission meeting. The ANC [...]

Published
2023

27. Mitt Romney Talks the State of U.S. Politics, the Republican Party at Georgetown University

Author

Inglima, Paulina

Subjects
Political parties, News, opinion and commentary, Sports and fitness, Republican Party (United States) -- Political activity -- Political aspects, Georgetown University -- Political activity -- Political aspects
Abstract

Byline: Paulina Inglima Senator Mitt Romney (R-Utah) said the rise of misinformation and performative politics is hurting American democracy in a moderated discussion at Georgetown University. 'Politics itself has become [...]

Published
2023

28. Black Student Affinity, Communal Gathering Space Opens

Author

Inglima, Paulina

Subjects
Company business management, News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima Blaxa Block, a Black student affinity and communal gathering space, opened in the LXR multipurpose room Sept. 30. Blaxa Block fulfilled one of the 11 demands from [...]

Published
2023

29. Advisory Neighborhood Commission Votes to Continue Georgetown's 'Streateries'

Author

Inglima, Paulina

Subjects
Local government, Business owners, News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima Georgetown's Advisory Neighborhood Commission (ANC 2E), a local government entity that represents the Georgetown, Burleith and Hillandale neighborhoods, voted to extend the permit on the District's 'streatery' [...]

Published
2023

30. Disability Cultural Center Collaborates with Diversability to Host Advocacy Panel

Author

Inglima, Paulina

Subjects
Arts centers, Disabled students, News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima Georgetown's Disability Cultural Center collaborated with Diversability, a community business dedicated to uplifting disabled voices , to host the Diversability Unplugged: Disability and Student Advocacy panel on [...]

Published
2023

31. GUSA Unanimously Passes Resolution to Urge University to Support Restoration of Foundry Branch Trolley Trestle

Author

Inglima, Paulina

Subjects
Foundries -- Laws, regulations and rules -- Political aspects, Light rail transit -- Political aspects -- Laws, regulations and rules, Public transportation -- Laws, regulations and rules -- Political aspects, Government regulation, News, opinion and commentary, Sports and fitness
Abstract

Byline: Paulina Inglima The Georgetown University Student Association Senate unanimously passed a resolution to urge the university to support the restoration of the Foundry Branch Trolley Trestle at its Sept. [...]

Published
2023

33. SARS-CoV-2 Is Not Detected in the Cerebrospinal Fluid of Encephalopathic COVID-19 Patients

Author

Dimitris G. Placantonakis, Maria Aguero-Rosenfeld, Abdallah Flaifel, John Colavito, Kenneth Inglima, David Zagzag, Matija Snuderl, Eddie Louie, Jennifer Ann Frontera, and Ariane Lewis

Subjects
SARS-CoV-2, COVID-19, CSF, encephalopathy, cerebrospinal fluid, Neurology. Diseases of the nervous system, RC346-429
Abstract

Neurologic manifestations of the novel coronavirus SARS-CoV-2 infection have received wide attention, but the mechanisms remain uncertain. Here, we describe computational data from public domain RNA-seq datasets and cerebrospinal fluid data from adult patients with severe COVID-19 pneumonia that suggest that SARS-CoV-2 infection of the central nervous system is unlikely. We found that the mRNAs encoding the ACE2 receptor and the TMPRSS2 transmembrane serine protease, both of which are required for viral entry into host cells, are minimally expressed in the major cell types of the brain. In addition, CSF samples from 13 adult encephalopathic COVID-19 patients diagnosed with the viral infection via nasopharyngeal swab RT-PCR did not show evidence for the virus. This particular finding is robust for two reasons. First, the RT-PCR diagnostic was validated for CSF studies using stringent criteria; and second, 61% of these patients had CSF testing within 1 week of a positive nasopharyngeal diagnostic test. We propose that neurologic sequelae of COVID-19 are not due to SARS-CoV-2 meningoencephalitis and that other etiologies are more likely mechanisms.

Published
2020
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36. Association of SARS-CoV-2 genomic load trends with clinical status in COVID-19: A retrospective analysis from an academic hospital center in New York City.

Author

Ioannis M Zacharioudakis, Fainareti N Zervou, Prithiv J Prasad, Yongzhao Shao, Atreyee Basu, Kenneth Inglima, Scott A Weisenberg, and Maria E Aguero-Rosenfeld

Subjects
Medicine, Science
Abstract

The Infectious Diseases Society of America has identified the use of SARS-CoV-2 genomic load for prognostication purposes as a key research question. We designed a retrospective cohort study that included adult patients with COVID-19 pneumonia who had at least 2 positive nasopharyngeal tests at least 24 hours apart to study the correlation between the change in the genomic load of SARS-CoV-2, as reflected by the Cycle threshold (Ct) value of the RT-PCR, with change in clinical status. The Sequential Organ Failure Assessment (SOFA) score was used as a surrogate for patients' clinical status. Among 457 patients with COVID-19 pneumonia between 3/31/2020-4/10/2020, we identified 42 patients who met the inclusion criteria. The median initial SOFA score was 2 (IQR 2-3). 20 out of 42 patients had a lower SOFA score on their subsequent tests. We identified a statistically significant inverse correlation between the change in SOFA score and change in the Ct value with a decrease in SOFA score by 0.05 (SE 0.02; p

Published
2020
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38. CO2 balance of boreal, temperate, and tropical forests derived from a global database

Author

LUYSSAERT, S, INGLIMA, I, JUNG, M, RICHARDSON, AD, REICHSTEIN, M, PAPALE, D, PIAO, SL, SCHULZE, E‐D, WINGATE, L, MATTEUCCI, G, ARAGAO, L, AUBINET, M, BEER, C, BERNHOFER, C, BLACK, KG, BONAL, D, BONNEFOND, J‐M, CHAMBERS, J, CIAIS, P, COOK, B, DAVIS, KJ, DOLMAN, AJ, GIELEN, B, GOULDEN, M, GRACE, J, GRANIER, A, GRELLE, A, GRIFFIS, T, GRÜNWALD, T, GUIDOLOTTI, G, HANSON, PJ, HARDING, R, HOLLINGER, DY, HUTYRA, LR, KOLARI, P, KRUIJT, B, KUTSCH, W, LAGERGREN, F, LAURILA, T, LAW, BE, LE MAIRE, G, LINDROTH, A, LOUSTAU, D, MALHI, Y, MATEUS, J, MIGLIAVACCA, M, MISSON, L, MONTAGNANI, L, MONCRIEFF, J, MOORS, E, MUNGER, JW, NIKINMAA, E, OLLINGER, SV, PITA, G, REBMANN, C, ROUPSARD, O, SAIGUSA, N, SANZ, MJ, SEUFERT, G, SIERRA, C, SMITH, M‐L, TANG, J, VALENTINI, R, VESALA, T, and JANSSENS, IA

Subjects
Climate Action, carbon cycle, CO2, forest ecosystems, global database, gross primary productivity, net ecosystem productivity, net primary productivity, Environmental Sciences, Biological Sciences, Ecology
Abstract

Terrestrial ecosystems sequester 2.1 Pg of atmospheric carbon annually. A large amount of the terrestrial sink is realized by forests. However, considerable uncertainties remain regarding the fate of this carbon over both short and long timescales. Relevant data to address these uncertainties are being collected at many sites around the world, but syntheses of these data are still sparse. To facilitate future synthesis activities, we have assembled a comprehensive global database for forest ecosystems, which includes carbon budget variables (fluxes and stocks), ecosystem traits (e.g. leaf area index, age), as well as ancillary site information such as management regime, climate, and soil characteristics. This publicly available database can be used to quantify global, regional or biome-specific carbon budgets; to re-examine established relationships; to test emerging hypotheses about ecosystem functioning [e.g. a constant net ecosystem production (NEP) to gross primary production (GPP) ratio]; and as benchmarks for model evaluations. In this paper, we present the first analysis of this database. We discuss the climatic influences on GPP, net primary production (NPP) and NEP and present the CO2 balances for boreal, temperate, and tropical forest biomes based on micrometeorological, ecophysiological, and biometric flux and inventory estimates. Globally, GPP of forests benefited from higher temperatures and precipitation whereas NPP saturated above either a threshold of 1500 mm precipitation or a mean annual temperature of 10 °C. The global pattern in NEP was insensitive to climate and is hypothesized to be mainly determined by nonclimatic conditions such as successional stage, management, site history, and site disturbance. In all biomes, closing the CO2 balance required the introduction of substantial biome-specific closure terms. Nonclosure was taken as an indication that respiratory processes, advection, and non-CO2 carbon fluxes are not presently being adequately accounted for. © 2007 Blackwell Publishing Ltd.

Published
2007

41. Soil C:N stoichiometry controls carbon sink partitioning between above-ground tree biomass and soil organic matter in high fertility forests

Author

Alberti G, Vicca S, Inglima I, Belelli-Marchesini L, Genesio L, Miglietta F, Marjanovic H, Martinez C, Matteucci G, D’Andrea E, Peressotti A, Petrella F, Rodeghiero M, and Cotrufo Maria F

Subjects
Net Root-derived Carbon, Ingrowth Cores, Soil C:N, Carbon Sequestration, Carbon Partitioning, Isotopes, Forestry, SD1-669.5
Abstract

The release of organic compounds from roots is a key process influencing soil carbon (C) dynamics and nutrient availability in terrestrial ecosystems. Through this process, plants stimulate microbial activity and soil organic matter (SOM) mineralization thus releasing nitrogen (N) that sustains gross and net primary production (GPP and NPP, respectively). Root inputs also contribute to SOM formation. In this study, we quantified the annual net root-derived C input to soil (Net-Croot) across six high fertility forests using an in-growth core isotope technique. On the basis of Net-Croot, wood and coarse root biomass changes, and eddy covariance data, we quantified net belowground C sequestration. Belowground C accumulation and GPP were inversely related to soil C:N, but not to climate or stand age. Soil C content and C:N were also related to soil texture. At these high fertility sites, biomass growth did not change with soil C:N; however, biomass growth-to-GPP ratio significantly increased with increasing soil C:N. This was true for both our six forest sites and for another 23 high fertility sites selected at a global scale. We suggest that, at high fertility sites, plant N demand interacts with soil C:N stoichiometry and microbial activity, resulting in higher allocation of C to above ground tree biomass with increasing soil C:N ratio. When C:N is high, microbes have a low C use efficiency, respire more of the fresh C inputs by roots and prime SOM decomposition, thereby increasing N availability for tree uptake. Soil C sequestration would therefore decrease, whereas the extra N released during SOM decomposition can promote tree growth and ecosystem C sink allocation in aboveground biomass. Conversely, C is sequestered in soil when low soil C:N promotes microbial C use efficiency and new SOM formation and stabilization on clay particles.

Published
2015
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42. Dynamical dipole excitation in the fission of a Ca 40 + Sm 152 composite system

Author

Parascandolo C., Pierroutsakou D., Alba R., Del Zoppo A., Maiolino C., Santonocito D., Agodi C., Baran V., Boiano A., Colonna M., Coniglione R., De Filippo E., Di Nitto A., Emanuele U., Farinon F., Guglielmetti A., Inglima G., La Commara M., La Rana G., Martin B., Mazzocchi C., Mazzocco M., Rizzo C., Romoli M., Sandoli M., Signorini C., Silvestri R., Soramel F., Trifiro A., Trimarchi M., Vardaci E., Parascandolo, C., Pierroutsakou, D., Alba, R., Del Zoppo, A., Maiolino, C., Santonocito, D., Agodi, C., Baran, V., Boiano, A., Colonna, M., Coniglione, R., De Filippo, E., Di Nitto, A., Emanuele, U., Farinon, F., Guglielmetti, A., Inglima, G., La Commara, M., La Rana, G., Martin, B., Mazzocchi, C., Mazzocco, M., Rizzo, C., Romoli, M., Sandoli, M., Signorini, C., Silvestri, R., Soramel, F., Trifiro, A., Trimarchi, M., and Vardaci, E.

Abstract

The excitation of the dynamical dipole mode was explored in the formation of a heavy composite system with mass A≃ 190, by investigating its fission channel. The composite system was produced through the charge asymmetric reaction, Ca40 + Sm152, and the nearly charge symmetric one, Ca48 +Sm144, at Elab = 11 and 10.1 MeV/nucleon, respectively. High-energy γ rays and light charged particles were detected in coincidence with the two fission fragments by means of the MEDEA multidetector array coupled to two parallel plate avalanche counters. The kinetic energy spectra of the light charged particles measured at different angles were used to infer the average excitation energy, the average mass, and the average charge of the produced nuclei whereas the time of flight and the emission angle of the fragments were employed to reconstruct the fission dynamics. The study of the γ-ray spectra and angular distributions for the selected fission events, allowed us to establish (i) the excitation of the giant dipole resonance in the composite system of both reactions and (ii) the excitation of the dynamical dipole mode in the dinucleus of the charge asymmetric reaction by isolating its prompt γ radiation through the difference technique. The present results on the dynamical dipole mode were compared with the experimental findings for the evaporation channel of the Ca40 + Sm152 reaction and moreover with calculations based on a collective bremsstrahlung analysis of the reaction dynamics. Interesting hints connecting the dynamical dipole γ radiation with the superheavy element quest are given.

Published
2022

44. Dynamical dipole excitation in the fission of a Ca40 + Sm152 composite system

Author

C. Parascandolo, D. Pierroutsakou, R. Alba, A. Del Zoppo, C. Maiolino, D. Santonocito, C. Agodi, V. Baran, A. Boiano, M. Colonna, R. Coniglione, E. De Filippo, A. Di Nitto, U. Emanuele, F. Farinon, A. Guglielmetti, G. Inglima, M. La Commara, G. La Rana, B. Martin, C. Mazzocchi, M. Mazzocco, C. Rizzo, M. Romoli, M. Sandoli, C. Signorini, R. Silvestri, F. Soramel, A. Trifirò, M. Trimarchi, and E. Vardaci

Published
2022

45. Dynamical dipole excitation in the fission of a Ca40 + Sm152 composite system

Author

Parascandolo, C., primary, Pierroutsakou, D., additional, Alba, R., additional, Del Zoppo, A., additional, Maiolino, C., additional, Santonocito, D., additional, Agodi, C., additional, Baran, V., additional, Boiano, A., additional, Colonna, M., additional, Coniglione, R., additional, De Filippo, E., additional, Di Nitto, A., additional, Emanuele, U., additional, Farinon, F., additional, Guglielmetti, A., additional, Inglima, G., additional, La Commara, M., additional, La Rana, G., additional, Martin, B., additional, Mazzocchi, C., additional, Mazzocco, M., additional, Rizzo, C., additional, Romoli, M., additional, Sandoli, M., additional, Signorini, C., additional, Silvestri, R., additional, Soramel, F., additional, Trifirò, A., additional, Trimarchi, M., additional, and Vardaci, E., additional

Published
2022
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47. Pathogen Species Is Associated With Mortality in Nosocomial Bloodstream Infection in Patients With COVID-19

Author

Gago, Juan, primary, Filardo, Thomas D, additional, Conderino, Sarah, additional, Magaziner, Samuel J, additional, Dubrovskaya, Yanina, additional, Inglima, Kenneth, additional, Iturrate, Eduardo, additional, Pironti, Alejandro, additional, Schluter, Jonas, additional, Cadwell, Ken, additional, Hochman, Sarah, additional, Li, Huilin, additional, Torres, Victor J, additional, Thorpe, Lorna E, additional, and Shopsin, Bo, additional

Published
2022
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48. Pathogen Species Is Associated With Mortality in Nosocomial Bloodstream Infection in Patients With COVID-19

Author

Juan Gago, Thomas D Filardo, Sarah Conderino, Samuel J Magaziner, Yanina Dubrovskaya, Kenneth Inglima, Eduardo Iturrate, Alejandro Pironti, Jonas Schluter, Ken Cadwell, Sarah Hochman, Huilin Li, Victor J Torres, Lorna E Thorpe, and Bo Shopsin

Subjects
Infectious Diseases, Oncology
Abstract

Background The epidemiology of nosocomial bloodstream infections (NBSIs) in patients with coronavirus disease 2019 (COVID-19) is poorly understood, due in part to substantial disease heterogeneity resulting from multiple potential pathogens. Methods We identified risk factors for NBSIs and examined the association between NBSIs and mortality in a retrospective cohort of patients hospitalized with COVID-19 in 2 New York City hospitals during the height of the pandemic. We adjusted for the potential effects of factors likely to confound that association, including age, race, illness severity upon admission, and underlying health status. Results Between January 1 and October 1, 2020, 1403 patients had a positive blood culture, and 79 and 101 met the stringent criteria for NBSI among non-COVID-19 and COVID-19 patients, respectively. NBSIs occurred almost exclusively among patients who were severely ill with COVID-19 at hospital admission. NBSIs were associated with elevated mortality, even after adjusting for baseline differences in COVID-19 illness (55% cases vs 45% controls; P = .13). Mortality was concentrated in patients with early-onset pneumonia caused by S. aureus and gram-negative bacteria. Less virulent Candida (49%) and Enterococcus (12%) species were the predominant cause of NBSI in the latter stages of hospitalization, after antibiotic treatment and COVID-19 treatments that attenuate immune response. Most Enterococcus and Candida infections did not have an identifiable source and were not associated with common risk factors for infection by these organisms. Conclusions Pathogen species and mortality exhibited temporal differences. Early recognition of risk factors among COVID-19 patients could potentially decrease NBSI-associated mortality through early COVID-19 and antimicrobial treatment.

Published
2021

49. Decreased summer drought affects plant productivity and soil carbon dynamics in a Mediterranean woodland

Author

M. F. Cotrufo, G. Alberti, I. Inglima, H. Marjanović, D. LeCain, A. Zaldei, A. Peressotti, and F. Miglietta

Subjects
Ecology, QH540-549.5, Life, QH501-531, Geology, QE1-996.5
Abstract

Precipitation patterns are expected to change in the Mediterranean region within the next decades, with projected decreases in total rainfall and increases in extreme events. We manipulated precipitation patterns in a Mediterranean woodland, dominated by Arbutus unedo L., to study the effects of changing precipitation regimes on above-ground net primary production (ANPP) and soil C dynamics, specifically plant-derived C input to soil and soil respiration (SR). Experimental plots were exposed to either a 20 % reduction of throughfall or to water addition targeted at maintaining soil water content above a minimum of 10 % v/v. Treatments were compared to control plots which received ambient precipitation. Enhanced soil moisture during summer months highly stimulated annual stem primary production, litter fall, SR and net annual plant-derived C input to soil which on average increased by 130 %, 26 %, 58 % and 220 %, respectively, as compared to the control. In contrast, the 20 % reduction in throughfall (equivalent to 10 % reduction in precipitation) did not significantly change soil moisture at the site, and therefore did not significantly affect ANPP or SR. We conclude that minor changes (around 10 % reduction) in precipitation amount are not likely to significantly affect ANPP or soil C dynamics in Mediterranean woodlands. However, if summer rain increases, C cycling will significantly accelerate but soil C stocks are not likely to be changed in the short-term. More studies involving modelling of long-term C dynamics are needed to predict if the estimated increases in soil C input under wet conditions is going to be sustained and if labile C is being substituted to stable C, with a negative effect on long-term soil C stocks.

Published
2011
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50. Impact of Streptococcus pneumoniae Urinary Antigen Testing in Patients With Community-Acquired Pneumonia Admitted Within a Large Academic Health System

Author

Adam Greenfield, Kassandra Marsh, Justin Siegfried, Ioannis Zacharioudakis, Nabeela Ahmed, Arnold Decano, Maria E Aguero-Rosenfeld, Kenneth Inglima, John Papadopoulos, and Yanina Dubrovskaya

Subjects
antimicrobial stewardship, Infectious Diseases, AcademicSubjects/MED00290, community-acquired pneumonia, Oncology, pneumococcal urinary antigen test, Major Articles
Abstract

Background Limited data support use of pneumococcal urinary antigen testing (PUAT) for patients with community-acquired pneumonia (CAP) as an antimicrobial stewardship tool. At our institution, CAP guidelines and admission order set were standardized to include universal PUAT. Methods This was a retrospective study of adults hospitalized in 2019 who had PUAT performed. We compared incidence and timing of de-escalation in PUAT- positive vs -negative groups and described patients’ outcomes. Results We evaluated 910 patients, 121 (13.3%) of whom were PUAT positive. No difference in baseline characteristics, including severity of illness, was observed between groups. Initial de-escalation occurred in 82.9% and 81.2% of PUAT-positive and -negative patients, respectively (P = .749). Median time to de-escalation was shorter in the PUAT-positive group (1 [interquartile range {IQR}, 0–2] day vs 1 [IQR, 1–2] day, P = .01). Within 24 hours of PUAT, more patients in the PUAT-positive group had atypical coverage discontinued (61.3% vs 47.2%, P = .026) without difference in methicillin-resistant Staphylococcus aureus (MRSA) agent discontinuation (or antipseudomonal de-escalation). Among the PUAT-positive group, unadjusted analysis demonstrated shorter median length of stay in patients who were de-escalated compared to those who were not (6 [IQR, 4–10] vs 8 [IQR, 7–12] days, P = .0005), without difference in the incidence of Clostridioides difficile, in-hospital mortality, or 30-day infection-related readmission. Conclusions We observed earlier de-escalation in the PUAT-positive group. This seems to be due to discontinuation of atypical rather than anti-MRSA or antipseudomonal coverage. Further antimicrobial stewardship interventions are warranted.

Published
2021

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