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In this brief report we followed the evolution of the COVID-19 Infodemic Risk Index during 2020 and clarified its connection with the epidemic waves, focusing specifically on their co-evolution in Europe, South America, and South-eastern Asia. Using 640 million tweets collected by the Infodemic Observatory and the open access dataset published by Our World in Data regarding COVID-19 worldwide reported cases, we analyze the COVID-19 infodemic vs. pandemic co-evolution from January 2020 to December 2020. We find that a characteristic pattern emerges at the global scale: a decrease in misinformation on Twitter as the number of COVID-19 confirmed cases increases. Similar local variations highlight how this pattern could be influenced both by the strong content moderation policy enforced by Twitter after the first pandemic wave and by the phenomenon of selective exposure that drives users to pick the most visible and reliable news sources available.