1. Ventriculoperitoneal shunt malfunction diagnosis based on substance dilution.
- Author
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Fu X, Chen Y, Duan W, Yang H, Xu J, Cheng X, and Zhang H
- Subjects
- Adult, Female, Humans, Hydrocephalus surgery, Male, Middle Aged, Postoperative Complications surgery, Reference Standards, Ventriculoperitoneal Shunt adverse effects, Equipment Failure, Indicator Dilution Techniques instrumentation, Ventriculoperitoneal Shunt instrumentation
- Abstract
Objective: Current methods for the diagnosis of ventriculoperitoneal (VP) shunt malfunction lack specific standards; therefore, it may be missed or misdiagnosed. Hence, providing a reliable diagnostic method will help improve the accuracy of preoperative decision-making. Therefore, the aim of the study was to provide a new method for the diagnosis of VP shunt malfunction., Methods: After in vitro testing, we enrolled a total of 12 patients with VP shunt malfunction. Before revision surgery, 0.1 mL of a 5% sodium valproate (SV) solution was injected into the reservoir; 0.1 mL of the cerebrospinal fluid (CSF) was withdrawn 20 minutes later from the reservoir to measure the SV concentration. The process was repeated on the seventh day after surgery and compared with the preoperative results., Results: The mean ± standard deviation preoperative SV concentration in the cerebrospinal fluid was greater than the postoperative concentration (5967.8 ± 1281.3 vs 391.1 ± 184.6 μg/mL, P = .001)., Conclusion: The proposed method is a reliable, safe, and relatively simple alternative for the diagnosis of VP shunt malfunction and further provides a reference for treatment., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2021
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