Search

Your search keyword '"Inderhees, Julica"' showing total 14 results
Start Over Author "Inderhees, Julica"
14 results on '"Inderhees, Julica"'

3. The reactive pyruvate metabolite dimethylglyoxal mediates neurological consequences of diabetes

Author

Rhein, Sina, Costalunga, Riccardo, Inderhees, Julica, Gürtzgen, Tammo, Faupel, Teresa Christina, Shaheryar, Zaib, Arrulo Pereira, Adriana, Othman, Alaa, Begemann, Kimberly, Binder, Sonja, Stölting, Ines, Dorta, Valentina, Nawroth, Peter P., Fleming, Thomas, Oexle, Konrad, Prevot, Vincent, Nogueiras, Ruben, Meyhöfer, Svenja, Meyhöfer, Sebastian M., and Schwaninger, Markus

Published
2024
Full Text
View/download PDF

10. Serum Metabolites as Potential Markers and Predictors of Depression-like Behavior and Effective Fluoxetine Treatment in Chronically Socially Isolated Rats.

Author

Filipović, Dragana, Inderhees, Julica, Korda, Alexandra, Tadić, Predrag, Schwaninger, Markus, Inta, Dragoš, and Borgwardt, Stefan

Subjects
MACHINE learning, RECEIVER operating characteristic curves, SUPPORT vector machines, RANDOM forest algorithms, MENTAL depression, LIQUID chromatography-mass spectrometry
Abstract

Metabolic perturbation has been associated with depression. An untargeted metabolomics approach using liquid chromatography-high resolution mass spectrometry was employed to detect and measure the rat serum metabolic changes following chronic social isolation (CSIS), an animal model of depression, and effective antidepressant fluoxetine (Flx) treatment. Univariate and multivariate statistics were used for metabolic data analysis and differentially expressed metabolites (DEMs) determination. Potential markers and predictive metabolites of CSIS-induced depressive-like behavior and Flx efficacy in CSIS were evaluated by the receiver operating characteristic (ROC) curve, and machine learning (ML) algorithms, such as support vector machine with linear kernel (SVM–LK) and random forest (RF). Upregulated choline following CSIS may represent a potential marker of depressive-like behavior. Succinate, stachydrine, guanidinoacetate, kynurenic acid, and 7-methylguanine were revealed as potential markers of effective Flx treatment in CSIS rats. RF yielded better accuracy than SVM–LK (98.50% vs. 85.70%, respectively) in predicting Flx efficacy in CSIS vs. CSIS, however, it performed almost identically in classifying CSIS vs. control (75.83% and 75%, respectively). Obtained DEMs combined with ROC curve and ML algorithms provide a research strategy for assessing potential markers or predictive metabolites for the designation or classification of stress-induced depressive phenotype and mode of drug action. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Metabolic Fingerprints of Effective Fluoxetine Treatment in the Prefrontal Cortex of Chronically Socially Isolated Rats: Marker Candidates and Predictive Metabolites

Author

Filipović, Dragana, Inderhees, Julica, Korda, Alexandra, Tadić, Predrag, Schwaninger, Markus, Inta, Dragoš, Borgwardt, Stefan, Filipović, Dragana, Inderhees, Julica, Korda, Alexandra, Tadić, Predrag, Schwaninger, Markus, Inta, Dragoš, and Borgwardt, Stefan

Abstract

The increasing prevalence of depression requires more effective therapy and the understanding of antidepressants’ mode of action. We carried out untargeted metabolomics of the prefrontal cortex of rats exposed to chronic social isolation (CSIS), a rat model of depression, and/or fluoxetine treatment using liquid chromatography–high resolution mass spectrometry. The behavioral phenotype was assessed by the forced swim test. To analyze the metabolomics data, we employed univariate and multivariate analysis and biomarker capacity assessment using the receiver operating characteristic (ROC) curve. We also identified the most predictive biomarkers using a support vector machine with linear kernel (SVM-LK). Upregulated myo-inositol following CSIS may represent a potential marker of depressive phenotype. Effective fluoxetine treatment reversed depressive-like behavior and increased sedoheptulose 7-phosphate, hypotaurine, and acetyl-L-carnitine contents, which were identified as marker candidates for fluoxetine efficacy. ROC analysis revealed 4 significant marker candidates for CSIS group discrimination, and 10 for fluoxetine efficacy. SVM-LK with accuracies of 61.50% or 93.30% identified a panel of 7 or 25 predictive metabolites for depressive-like behavior or fluoxetine effectiveness, respectively. Overall, metabolic fingerprints combined with the ROC curve and SVM-LK may represent a new approach to identifying marker candidates or predictive metabolites for ongoing disease or disease risk and treatment outcome.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results