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Your search keyword '"Inci S, Doğan"' showing total 2 results
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2 results on '"Inci S, Doğan"'

1. Synthesis of Some Novel 2-Substitutedbenzyl-(4)7-phenyl-1H-benzo[d]imidazoles in Mild Conditions as Potent Anti-Tyrosinase and Antioxidant Agents

Author

İnci S, Doğan, Arzu, Özel, Zeynep, Birinci, Burak, Barut, Hasan E, Sellitepe, and Bahittin, Kahveci

Subjects
Structure-Activity Relationship, Dose-Response Relationship, Drug, Monophenol Monooxygenase, Pyrones, Imidazoles, Enzyme Inhibitors, In Vitro Techniques, Antioxidants
Abstract

Novel 2-substitutedbenzyl-4(7)-phenyl-1H-benzo[d]imidazole compounds were synthesized and characterized. Although 2a and 2b were reported previously in the literature, 11 compounds were synthesized (nine of them were newly synthesized) and the tyrosinase inhibitory effects and antioxidant activities of these compounds were studied for the first time. All of the synthesized compounds displayed certain inhibitory effects on tyrosinase, with IC

Published
2016

2. Synthesis of some novel 1,2,4-triazol-3-one derivatives bearing the salicyl moiety and their anticonvulsant activities

Author

Bahittin, Kahveci, Emre, Menteşe, Emre, Akkaya, Fatih, Yılmaz, Inci S, Doğan, and Arzu, Ozel

Subjects
Disease Models, Animal, Electroshock, Mice, Structure-Activity Relationship, Time Factors, Molecular Structure, Seizures, Drug Design, Animals, Anticonvulsants, Triazoles, Salicylates
Abstract

A series of new 1,2,4-triazole-3-one derivatives bearing the salicyl moiety were synthesized by using microwave irradiation, and their chemical structures were identified by IR, (1) H NMR, (13) C NMR, elemental analysis, and LC-MS. The anticonvulsant activities of the compounds 4a-c, 4e, and 5a-e were evaluated by the Anticonvulsant Screening Program of the National Institute of Health, USA. The compounds had moderate anticonvulsant activities in the maximum electroshock-induced seizure and minimal clonic seizure models in mice, without any neurotoxic effects.

Published
2013

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