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1,360 results on '"Inagaki, H."'

3. The efficacy of excimer laser coronary atherectomy in ST-elevation myocardial infarction: a report from the STELA registry

Author

Matsuda, Y, primary, Yonetsu, T, additional, Kurihara, K, additional, Kakuta, T, additional, Shimizu, S, additional, Matsumura, A, additional, Inagaki, H, additional, Onishi, Y, additional, Sakurai, K, additional, Tsuchiyama, T, additional, Ashikaga, T, additional, Fuji, H, additional, Kobayashi, K, additional, and Sasano, T, additional

Published
2023
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6. Reference values of gait parameters measured with a plantar pressure platform in community-dwelling older Japanese adults

Author

Kawai H, Taniguchi Y, Seino S, Sakurai R, Osuka Y, Obuchi S, Watanabe Y, Kim H, Inagaki H, Kitamura A, Awata S, and Shinkai S

Subjects
gait parameter, variation coefficient, community-dwelling, older adult, reference value, Geriatrics, RC952-954.6
Abstract

Hisashi Kawai, Yu Taniguchi, Satoshi Seino, Ryota Sakurai, Yosuke Osuka, Shuichi Obuchi, Yutaka Watanabe, Hunkyung Kim, Hiroki Inagaki, Akihiko Kitamura, Shuichi Awata, Shoji ShinkaiTokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, JapanBackground: Gait measures such as gait speed, stride length, step width, and stance duration change with advanced age and are associated with adverse health outcomes among older adults. The stride-to-stride variabilities of gait measures are also related to falls and cognitive decline in older adults; however, reference values of these gait parameters in older Japanese adults do not exist. This study aimed to determine the reference values of gait parameters as measured by a plantar pressure platform in community-dwelling older Japanese adults.Methods: Community-dwelling adults (N=1,212) who were independent in basic activities of daily living and aged 70–96 years (491 men, 721 women) completed the gait performance measurement in a geriatric health assessment. We assessed 10 gait performance measures with a plantar pressure platform system (P-WALK, BTS Bioengineering) and calculated means and coefficient of variations (CVs) of the gait measures as well as quintiles for those gait parameters per age group among men and women.Results: Mean (SDs) of gait speed, stride length, step width, and stance durations were 1.26 (0.24) meters per second (m/s), 121.9 (19.8) cm, 24.0 (3.2) cm, and 552.4 (60.4) milliseconds (ms), respectively, in men, and 1.27 (0.21) m/s, 115.7 (16.3) cm, 17.9 (2.8) cm, and 517.6 (59.8) ms, respectively, in women. Mean of CVs (SD) of stride length, step width, and single-stance duration were 2.76 (1.35), 12.06 (3.98), and 5.74 (2.66), respectively, in men and 2.69 (1.24), 15.65 (4.53), and 5.77 (2.40), respectively, in women. Gait parameters (except CVs of step width) declined significantly with age regardless of gender (P< 0.01 for trends).Conclusion: This study determined age group dependent gait parameter reference values, presented as means with quintile ranges, in community-dwelling older Japanese adults. These reference values may be useful metrics for gait assessment in the elderly.Keywords: gait parameter, variation coefficient, community-dwelling, older adult, reference value

Published
2019

9. Briefings

Author

Yang, C., Tibbitt, M. W., Basta, L., Anseth, K. S., Valley, J. W., Inagaki, H. K., and Legendre, M.

Published
2014

12. PD-035 Efficacy and safety of second-line irinotecan based chemotherapy in early relapse patients with gastric cancer after adjuvant chemotherapy: exploratory subgroup analysis of TRICS trial

Author

Nishikawa, K., Fujitani, K., Inagaki, H., Akamaru, Y., Tokunaga, S., Takagi, M., Tamura, S., Sugimoto, N., Shigematsu, T., Yoshikawa, T., Ishiguro, T., Nakamura, M., Yamane, T., Yamada, M., Imano, M., Iijima, S., Nashimoto, A., Morita, S., Miyashita, Y., Tsuburaya, A., Sakamoto, J., and Tsujinaka, T.

Published
2016
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14. Survey report on damage caused by 2019 Typhoon Hagibis in Marumori Town, Miyagi Prefecture, Japan

Author

Moriguchi, S., primary, Matsugi, H., additional, Ochiai, T., additional, Yoshikawa, S., additional, Inagaki, H., additional, Ueno, S., additional, Suzuki, M., additional, Tobita, Y., additional, Chida, T., additional, Takahashi, K., additional, Shibayama, A., additional, Hashimoto, M., additional, Kyoya, T., additional, and Dolojan, N.L.J., additional

Published
2021
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23. A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus. (Case Report)

Author

Hosaka, S., Nakamura, N., Akamatsu, T., Fujisawa, T., Ogiwara, Y., Kiyosawa, K., Hidaka, E., Ota, H., Katsuyama, T., and Inagaki, H.

Subjects
Lymphomas -- Identification and classification -- Case studies, Esophageal cancer -- Case studies, Health
Abstract

We report a very rare case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus. An 83 year old woman was referred to our hospital in [...]

Published
2002

40. Texture development in Al alloys during tensile testing

Author

Ohtani, S. and Inagaki, H.

Abstract

Tensile tests were made on commercially pure Al (A1050), Al-4.4 wt.% Mg (A5182) and Al-4 wt.% Cu (A2017) alloys by varying the test temperature and the strain rate. Textures developed at various stages of the tensile deformation were investigated with the orientation distribution function analysis. During the tensile test of pure Al with a strain rate of 3 × 10–4s –1at 20 °C, the tensile axis readily rotated toward the <111> stable end orientation. However, such a rotation occurred only at the later stage of the tensile deformation near the tensile stress, where the stress– strain curve became flat, and where work hardening was almost saturated. It is suggested that the size and the morphology of the dislocation cell, which had developed up to this stage, played a significant role in the subsequent texture development. In fact, the addition of Mg and Cu, which inhibited the development of the well-defined cell structure due to the Portevin –Le Chatelier effect, strongly suppressed the rotation of the tensile axis toward <111>. In all the materials investigated, textures were not affected by the strain rate and also by the temperature of the tensile test.

Published
2022
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48. Severe neurocognitive and growth disorders due to variation in THOC2, an essential component of nuclear mRNA export machinery

Author

Kumar, R, Gardner, A, Homan, CC, Douglas, E, Mefford, H, Wieczorek, D, Lüdecke, HJ, Stark, Z, Sadedin, S, Nowak, CB, Douglas, J, Parsons, G, Mark, P, Loidi, L, Herman, GE, Mihalic Mosher, T, Gillespie, MK, Brady, L, Tarnopolsky, M, Madrigal, I, Eiris, J, Domènech Salgado, L, Rabionet, R, Strom, TM, Ishihara, N, Inagaki, H, Kurahashi, H, Dudding-Byth, T, Palmer, EE, Field, M, Gecz, J, Kumar, R, Gardner, A, Homan, CC, Douglas, E, Mefford, H, Wieczorek, D, Lüdecke, HJ, Stark, Z, Sadedin, S, Nowak, CB, Douglas, J, Parsons, G, Mark, P, Loidi, L, Herman, GE, Mihalic Mosher, T, Gillespie, MK, Brady, L, Tarnopolsky, M, Madrigal, I, Eiris, J, Domènech Salgado, L, Rabionet, R, Strom, TM, Ishihara, N, Inagaki, H, Kurahashi, H, Dudding-Byth, T, Palmer, EE, Field, M, and Gecz, J

Abstract

Highly conserved TREX-mediated mRNA export is emerging as a key pathway in neuronal development and differentiation. TREX subunit variants cause neurodevelopmental disorders (NDDs) by interfering with mRNA export from the cell nucleus to the cytoplasm. Previously we implicated four missense variants in the X-linked THOC2 gene in intellectual disability (ID). We now report an additional six affected individuals from five unrelated families with two de novo and three maternally inherited pathogenic or likely pathogenic variants in THOC2 extending the genotypic and phenotypic spectrum. These comprise three rare missense THOC2 variants that affect evolutionarily conserved amino acid residues and reduce protein stability and two with canonical splice-site THOC2 variants that result in C-terminally truncated THOC2 proteins. We present detailed clinical assessment and functional studies on a de novo variant in a female with an epileptic encephalopathy and discuss an additional four families with rare variants in THOC2 with supportive evidence for pathogenicity. Severe neurocognitive features, including movement and seizure disorders, were observed in this cohort. Taken together our data show that even subtle alterations to the canonical molecular pathways such as mRNA export, otherwise essential for cellular life, can be compatible with life, but lead to NDDs in humans.

Published
2018

49. Identification of an enhancer region for immune activation in the human GTP cyclohydrolase i gene

Author

Liang, Y., Inagaki, H., Hao, Q., Sakamoto, M., Ohye, T., Suzuki, T., and Ichinose, Hiroshi

Subjects
Lipopolysaccharides, Transcriptional Activation, GTP cyclohydrolase I, Response element, Biophysics, Electrophoretic Mobility Shift Assay, Biochemistry, Gene Expression Regulation, Enzymologic, Cell Line, Interferon-gamma, Mice, Transcription (biology), Human Umbilical Vein Endothelial Cells, Transcriptional regulation, Animals, Humans, Electrophoretic mobility shift assay, GTP Cyclohydrolase, Enhancer, Molecular Biology, Proto-Oncogene Proteins c-ets, biology, Ccaat-enhancer-binding proteins, Tumor Necrosis Factor-alpha, Macrophages, Cell Biology, Macrophage Activation, Molecular biology, Enhancer Elements, Genetic, CCAAT-Enhancer-Binding Proteins, biology.protein, Chromatin immunoprecipitation
Abstract

GTP cyclohydrolase I (GCH) catalyzes the first and rate limiting step reaction for the de novo synthesis of 5,6,7,8-tetrahydrobiopterin (BH4). The expression of GCH is dramatically elevated by immune activation, while the mechanism remains to be elucidated. In this study, we investigated the transcription mechanism of the GCH gene using lipopolysaccharide (LPS) to stimulate mouse macrophage RAW264.7 cells. With luciferase assay, we found a highly conserved enhancer region spanning approximately 300 bp in intron 1 of GCH gene as a response element to LPS stimulation. The same enhancer region was also responsible for the induction of the GCH gene by IFN-γ and TNF-α in HUVECs. With electrophoresis mobility shift assay (EMSA) and site directed mutation analysis, we identified two key fragments containing C/EBP and Ets binding motifs within the enhancer. Furthermore, C/EBP-β was involved in LPS activated GCH transcription through direct binding to the enhancer shown by supershift, chromatin immunoprecipitation, and RNA interference experiments. In conclusion, our findings uncovered a novel mechanism of GCH transcriptional regulation by immune activation.

Published
2013

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