Search

Your search keyword '"Inaba, Toshiki"' showing total 39 results
Start Over Author "Inaba, Toshiki"
39 results on '"Inaba, Toshiki"'

10. Microbial lipopolysaccharide‐induced inflammation contributes to cognitive impairment and white matter lesion progression in diet‐induced obese mice with chronic cerebral hypoperfusion.

Author

Inaba, Toshiki, Yamashiro, Kazuo, Kurita, Naohide, Ueno, Yuji, Miyamoto, Nobukazu, Hira, Kenichiro, Nakajima, Sho, Kijima, Chikage, Nakaguro, Ryohei, Urabe, Takao, and Hattori, Nobutaka

Subjects
*COGNITION disorders, *WHITE matter (Nerve tissue), *LOW-fat diet, *HIGH-fat diet, *IMMOBILIZATION stress, *COMPULSIVE eating, CAROTID artery stenosis
Abstract

Aims: White matter lesions (WMLs) are involved in the pathological processes leading to cognitive decline and dementia. We examined the mechanisms underlying the exacerbation of ischemia‐induced cognitive impairment and WMLs by diet‐induced obesity, including lipopolysaccharide (LPS)‐triggered neuroinflammation via toll‐like receptor (TLR) 4. Methods: Wild‐type (WT) and TLR4‐knockout (KO) C57BL/6 mice were fed a high‐fat diet (HFD) or low‐fat diet (LFD), and subjected to bilateral carotid artery stenosis (BCAS). Diet groups were compared for changes in gut microbiota, intestinal permeability, systemic inflammation, neuroinflammation, WML severity, and cognitive dysfunction. Results: In WT mice, HFD induced obesity and increased cognitive impairment and WML severity compared with LFD‐fed mice following BCAS. HFD caused gut dysbiosis and increased intestinal permeability, and plasma LPS and pro‐inflammatory cytokine concentrations. Furthermore, HFD‐fed mice had higher LPS levels and higher neuroinflammatory status, including increased TLR4 expression, in WMLs. In TLR4‐KO mice, HFD also caused obesity and gut dysbiosis but did not increase cognitive impairment or WML severity after BCAS. No difference was found between HFD‐ and LFD‐fed KO mice for LPS levels or inflammatory status in either plasma or WMLs. Conclusion: Inflammation triggered by LPS–TLR4 signaling may mediate obesity‐associated exacerbation of cognitive impairment and WMLs from brain ischemia. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

13. Mucosal‐Associated Invariant T Cells Are Involved in Acute Ischemic Stroke by Regulating Neuroinflammation

Author

Nakajima, Sho, primary, Tanaka, Ryota, additional, Yamashiro, Kazuo, additional, Chiba, Asako, additional, Noto, Daisuke, additional, Inaba, Toshiki, additional, Kurita, Naohide, additional, Miyamoto, Nobukazu, additional, Kuroki, Takuma, additional, Shimura, Hideki, additional, Ueno, Yuji, additional, Urabe, Takao, additional, Miyake, Sachiko, additional, and Hattori, Nobutaka, additional

Published
2021
Full Text
View/download PDF

14. JCB899577 Supplemental Material - Supplemental material for Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia

Author

Naohide Kurita, Yamashiro, Kazuo, Kuroki, Takuma, Tanaka, Ryota, Urabe, Takao, Ueno, Yuji, Nobukazu Miyamoto, Takanashi, Masashi, Shimura, Hideki, Inaba, Toshiki, Yamashiro, Yuichiro, Nomoto, Koji, Matsumoto, Satoshi, Takahashi, Takuya, Tsuji, Hirokazu, Asahara, Takashi, and Hattori, Nobutaka

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, JCB899577 Supplemental Material for Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia by Naohide Kurita, Kazuo Yamashiro, Takuma Kuroki, Ryota Tanaka, Takao Urabe, Yuji Ueno, Nobukazu Miyamoto, Masashi Takanashi, Hideki Shimura, Toshiki Inaba, Yuichiro Yamashiro, Koji Nomoto, Satoshi Matsumoto, Takuya Takahashi, Hirokazu Tsuji, Takashi Asahara and Nobutaka Hattori in Journal of Cerebral Blood Flow & Metabolism

Published
2020
Full Text
View/download PDF

39. Neurogenesis and differentiation after domic acid induced nerodegeneration in adut rat hippocampus

Author

Kato, Kengo, primary, Kamiya, Tatsushi, additional, Shimazaki, Kuniko, additional, Yokota, Hidenori, additional, Oguro, Keiji, additional, Miyawaki, Takahiro, additional, Nito, Cikako, additional, Amemiya, Simon, additional, Nishiyama, Yasuhiro, additional, Suda, Satoshi, additional, Inaba, Toshiki, additional, Ueda, Masayuki, additional, and Katayama, Yasuo, additional

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results