Search

Your search keyword '"Imre, M."' showing total 800 results
Start Over Author "Imre, M."
800 results on '"Imre, M."'

2. Converged ensemble simulations of climate: possible trends in total solar irradiance cannot explain global warming alone

Author

Gábor Drótos, Mátyás Herein, Tímea Haszpra, and Imre M. Jánosi

Subjects
climate change, total solar irradiance, ensemble simulations, snapshot attractors, internal variability, Science
Abstract

We address the hypothetical question of whether an increasing total solar irradiance (TSI) trend, without anthropogenic contributions, could be sufficient to explain the ongoing global warming. To this end, the intermediate-complexity climate model PlaSim is used. To consider the total internal variability, we present a set of ensemble simulations, with different forcing histories in TSI and CO2 concentration, that have converged sufficiently tightly to the relevant probability distributions to provide a satisfactory bound on any spurious trend possibly arising from a sampling bias; similar bounds on any other unforced contributions to ensemble mean trends are also estimated. A key point is the consideration, among the forcing histories, the steepest increasing trend in TSI that is still consistent with observations according to a recent study; thereby, we essentially revisit corresponding TSI reconstructions, more than 20 years after their last modeling-based evaluation, by improving the analysis through taking care of all possible sources of error or uncertainty and incorporating data that have become available since then. Without any change in CO2 concentration, our TSI trend (i.e., and upper bound on actual TSI trends) is found to be insufficient to produce outcomes compatible with the observational record in global mean surface temperature (GMST) with a nonnegligible probability. We formalize our statement for quantifiers of GMST trends through evaluating their distributions over the ensemble, and we speculate that the hypothesis about the exclusive role of an increasing TSI remains implausible even beyond our particular model setup. At the same time, if we consider a constant TSI, and the observational record in CO2 concentration is applied as forcing, the simulation results and the recorded GMST match well. While we currently need to leave the question of a precise attribution open, we conclude by pointing out that an attribution of the ongoing global warming to an increasing TSI alone could be made plausible only if a bias in the set of land-based instrumental temperature measurements were increasing more rapidly than commonly estimated; an assessment of the latter possibility is out of the scope of our study, as well as addressing solar forcing mechanisms beyond the effect of TSI.

Published
2024
Full Text
View/download PDF

3. Intestinal endoparasitism in wild cat (Felis silvestris) from Banat area (Romania)

Author

Mederle N., Darabus G., Stancu A., Pentea M., Imre M., Luca I., Pavlovic I., and Zdravković N.

Subjects
wild cat, endoparasitism, zoonotic risk, Microbiology, QR1-502
Abstract

The wild cat (Felis silvestris), spread in Romania from the Danube Delta to the mountain range is present in the Banat area, on the hunting ground that can be contaminated with different stage developmental forms of parasites, some of them having real zoonotic potential. The wild cat is an animal protected by the Romanian law of protection animals.

Published
2023
Full Text
View/download PDF

4. Production and electromagnetic decay of hyperons: a feasibility study with HADES as a Phase-0 experiment at FAIR

Author

Adamczewski-Musch, J., Belyaev, A., Blanco, A., Blume, C., Charlotte, C., Borisenko, D. S., Chlad, L., Chudoba, P., Ciepał, I., Derichs, A., Dittert, D., Dreyer, J., Esmail, W. A., Fateev, O., Fonte, P., Friese, J., Fröhlich, I., Förtsch, J., Galatyuk, T., Georgadze, I., Golosov, O., Golubeva, M., Greifenhagen, R., Grunwald, M., Grzonka, D., Guber, F., Gumberidze, M., Harabasz, S., Heinz, T., Heybeck, B., Höhne, C., Holona, M., Holzmann, R., Huck, H., Ierusalimov, A., Imre, M., Ivashkin, A., Kämpfer, B., Kampert, K-H., Kardan, B., Kedych, V., Khomyakov, V., Koenig, I., Koenig, W., Kohls, M., Kornakov, G., Kornas, F., Kotte, R., Kozela, A., Kozlov, V., Kres, I., Kuboś, J., Kugler, A., Kulessa, P., Ladygin, V., Lalik, R., Galliard, C. Le, Lebedev, A., Lebedev, S., Linev, S., Lopes, L., Lorenz, M., Lykasov, G., Malige, A., Markert, J., Matulewicz, T., Michel, J., Morozov, S., Müntz, C., Naumann, L., Nowakowski, K., Orfanitsky, S., Otto, J. -H., Patel, V., Pauly, C., Pechenov, V., Pechenova, O., Andrade, G. Perez, Petukhov, O., Pfeifer, D., Piasecki, K., Pietraszko, J., Prozorov, A., Przygoda, W., Pysz, K., Ramstein, B., Rathod, N., Regina, J., Reshetin, A., Reznikov, S., Rieger, J. T., Ritman, J., Rodriguez-Ramos, P., Rost, A., Rustamov, A., Salabura, P., Saraiva, J., Schild, N., Schwab, E., Schönning, K., Scozzi, F., Seck, F., Selyuzhenkov, I., Serdyuk, V., Shabanov, A., Singh, U., Smyrski, J., Sobiella, M., Spies, S., Strikhanov, M., Ströbele, H., Stroth, J., Sumara, K., Svoboda, O., Szala, M., Szewczyk, J., Taranenko, A., Tlusty, P., Traxler, M., Wagner, V., Wasiluk, M., Weber, A. A., Wendisch, C., Wintz, P., Włoch, B., Zbroszczyk, H. P., Zherebzova, E., Zhilin, A., Zinchenko, A., and Zumbruch, P.

Subjects
Nuclear Experiment
Abstract

A feasibility study has been performed in order to investigate the performance of the HADES detector to measure the electromagnetic decays of the hyperon resonances $\Sigma(1385)^0$, $\Lambda(1405)$ and $\Lambda{\Lambda}(1520)$ as well as the production of double strange baryon systems $\Xi^-$ and $\Lambda\Lambda$ in p+p reactions at a beam kinetic energy of 4.5 GeV. The existing HADES detector will be upgraded by a new Forward Detector, which extends the detector acceptance into a range of polar angles that plays a crucial role for these investigations. The analysis of each channel is preceded by a consideration of the production cross-sections. Afterwards the expected signal count rates using a target consisting of either liquid hydrogen or polyethylene are summarized., Comment: Draft prepared by Rafa{\l} Lalik, James Ritman, Piotr Salabura, 19 pages, 21 figures, 4 tables

Published
2020
Full Text
View/download PDF

5. Laboratory investigations on the resonant feature of `dead water' phenomenon

Author

Medjdoub, Karim, Jánosi, Imre M., and Vincze, Miklós

Subjects
Physics - Fluid Dynamics
Abstract

Interfacial internal wave excitation in the wake of towed ships is studied experimentally in a quasi-two layer fluid. At a critical `resonant' towing velocity, whose value depends on the structure of the vertical density profile, the amplitude of the internal wave train following the ship reaches a maximum, in unison with the development of a drag force acting on the vessel, known in the maritime literature as `dead water'. The amplitudes and wavelengths of the emerging internal waves are evaluated for various ship speeds, ship lengths and stratification profiles. The results are compared to linear two- and three-layer theories of freely propagating waves and lee waves. We find that despite the fact that the observed internal waves can have considerable amplitudes, linear theories can still provide a surprisingly adequate description of subcritical-to-supercritical transition and the associated amplification of internal waves.

Published
2019
Full Text
View/download PDF

6. Large-scale vorticity generation and kinetic energy budget along the U.S. West Coast

Author

Tóth, Gábor, Homonnai, Viktória, and Jánosi, Imre M.

Subjects
Physics - Atmospheric and Oceanic Physics, Physics - Fluid Dynamics
Abstract

We attempt to evaluate energy budget over a restricted but extremely well studied oceanic region along the shorelines of Oregon and California. The analysis is based on a recently updated geostrophic flow field data set covering 22 years with daily resolution on a grid of 0.25$^\circ\times$0.25$^\circ$, and turbulent wind stress data from the ERA-Interim reanalysis over the same geographic region with the same temporal and spatial resolutions. Integrated 2D kinetic energy, enstrophy, wind stress work and { kinetic energy tendency} are determined separately for the shore- and open water regions. The empirical analysis is supported by 2D lattice Boltzmann simulations of freely decaying vortices along a rough solid wall, which permits to separate the pure shoreline effects and dissipation properties of surface flow fields. Comparisons clearly demonstrate that kinetic energy and vorticity { of the geostrophic flow field} are mostly generated along the shorelines and advected to the open water regions, where the net wind stress work is almost negligible. Our results support that the geostrophic flow field is quasistationary on the timescale of a couple of days, thus total forcing is practically equal to total dissipation. Estimates of unknown terms in the equation of oceanic kinetic energy budget are based on other studies, nevertheless our results suggest that { an effective} eddy kinematic viscosity is in the order of magnitude $10^{-2}$ m$^2$/s along the shorelines, and it is lower { by a factor of two} in the open water region.

Published
2017

9. Despite its sequence identity with canonical H4, Drosophila H4r product is enriched at specific chromatin regions

Author

Andrea Ábrahám, Zoltán Villányi, Nóra Zsindely, Gábor Nagy, Áron Szabó, László Bodai, László Henn, and Imre M. Boros

Subjects
Medicine, Science
Abstract

Abstract Histone variants are different from their canonical counterparts in structure and are encoded by solitary genes with unique regulation to fulfill tissue or differentiation specific functions. A single H4 variant gene (His4r or H4r) that is located outside of the histone cluster and gives rise to a polyA tailed messenger RNA via replication-independent expression is preserved in Drosophila strains despite that its protein product is identical with canonical H4. In order to reveal information on the possible role of this alternative H4 we epitope tagged endogenous H4r and studied its spatial and temporal expression, and revealed its genome-wide localization to chromatin at the nucleosomal level. RNA and immunohistochemistry analysis of H4r expressed under its cognate regulation indicate expression of the gene throughout zygotic and larval development and presence of the protein product is evident already in the pronuclei of fertilized eggs. In the developing nervous system a slight disequibrium in H4r distribution is observable, cholinergic neurons are the most abundant among H4r-expressing cells. ChIP-seq experiments revealed H4r association with regulatory regions of genes involved in cellular stress response. The data presented here indicate that H4r has a variant histone function.

Published
2022
Full Text
View/download PDF

10. Predictive Potential of RNA Polymerase B (II) Subunit 1 (RPB1) Cytoplasmic Aggregation for Neoadjuvant Chemotherapy Failure

Author

Bence Nagy-Mikó, Orsolya Németh-Szatmári, Réka Faragó-Mészáros, Aliz Csókási, Bence Bognár, Nóra Ördög, Barbara N. Borsos, Hajnalka Majoros, Zsuzsanna Ujfaludi, Orsolya Oláh-Németh, Aliz Nikolényi, Ágnes Dobi, Renáta Kószó, Dóra Sántha, György Lázár, Zsolt Simonka, Attila Paszt, Katalin Ormándi, Tibor Pankotai, Imre M. Boros, Zoltán Villányi, and András Vörös

Subjects
RPB1, RNAPII, CCR4-NOT, assemblysomes, condensates, aggregation, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

We aimed to investigate the contribution of co-translational protein aggregation to the chemotherapy resistance of tumor cells. Increased co-translational protein aggregation reflects altered translation regulation that may have the potential to buffer transcription under genotoxic stress. As an indicator for such an event, we followed the cytoplasmic aggregation of RPB1, the aggregation-prone largest subunit of RNA polymerase II, in biopsy samples taken from patients with invasive carcinoma of no special type. RPB1 frequently aggregates co-translationally in the absence of proper HSP90 chaperone function or in ribosome mutant cells as revealed formerly in yeast. We found that cytoplasmic foci of RPB1 occur in larger sizes in tumors that showed no regression after therapy. Based on these results, we propose that monitoring the cytoplasmic aggregation of RPB1 may be suitable for determining—from biopsy samples taken before treatment—the effectiveness of neoadjuvant chemotherapy.

Published
2023
Full Text
View/download PDF

13. A new argument against cooling by convective air eddies formed above sunlit zebra stripes

Author

Ádám Pereszlényi, Dénes Száz, Imre M. Jánosi, and Gábor Horváth

Subjects
Medicine, Science
Abstract

Abstract There is a long-lasting debate about the possible functions of zebra stripes. According to one hypothesis, periodical convective air eddies form over sunlit zebra stripes which cool the body. However, the formation of such eddies has not been experimentally studied. Using schlieren imaging in the laboratory, we found: downwelling air streams do not form above the white stripes of light-heated smooth or hairy striped surfaces. The influence of stripes on the air stream formation (facilitating upwelling streams and hindering horizontal stream drift) is negligible higher than 1–2 cm above the surface. In calm weather, upwelling air streams might form above sunlit zebra stripes, however they are blown off by the weakest wind, or even by the slowest movement of the zebra. These results forcefully contradict the thermoregulation hypothesis involving air eddies.

Published
2021
Full Text
View/download PDF

15. Converged ensemble simulations of climate: possible trends in total solar irradiance cannot explain global warming alone.

Author

Drótos, Gábor, Herein, Mátyás, Haszpra, Tímea, Jánosi, Imre M., Zorita, Eduardo, and Elias, Ana G.

Subjects
GLOBAL warming, ATMOSPHERIC models, SURFACE temperature, DISTRIBUTION (Probability theory), TEMPERATURE measurements
Abstract

We address the hypothetical question of whether an increasing total solar irradiance (TSI) trend, without anthropogenic contributions, could be sufficient to explain the ongoing global warming. To this end, the intermediate-complexity climate model PlaSim is used. To consider the total internal variability, we present a set of ensemble simulations, with different forcing histories in TSI and CO2 concentration, that have converged sufficiently tightly to the relevant probability distributions to provide a satisfactory bound on any spurious trend possibly arising from a sampling bias; similar bounds on any other unforced contributions to ensemble mean trends are also estimated. A key point is the consideration, among the forcing histories, the steepest increasing trend in TSI that is still consistent with observations according to a recent study; thereby, we essentially revisit corresponding TSI reconstructions, more than 20 years after their last modeling-based evaluation, by improving the analysis through taking care of all possible sources of error or uncertainty and incorporating data that have become available since then. Without any change in CO2 concentration, our TSI trend (i.e., and upper bound on actual TSI trends) is found to be insufficient to produce outcomes compatible with the observational record in global mean surface temperature (GMST) with a nonnegligible probability. We formalize our statement for quantifiers of GMST trends through evaluating their distributions over the ensemble, and we speculate that the hypothesis about the exclusive role of an increasing TSI remains implausible even beyond our particular model setup. At the same time, if we consider a constant TSI, and the observational record in CO2 concentration is applied as forcing, the simulation results and the recorded GMST match well. While we currently need to leave the question of a precise attribution open, we conclude by pointing out that an attribution of the ongoing global warming to an increasing TSI alone could be made plausible only if a bias in the set of land-based instrumental temperature measurements were increasing more rapidly than commonly estimated; an assessment of the latter possibility is out of the scope of our study, as well as addressing solar forcing mechanisms beyond the effect of TSI. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Sunflower inflorescences absorb maximum light energy if they face east and afternoons are cloudier than mornings

Author

Gábor Horváth, Judit Slíz-Balogh, Ákos Horváth, Ádám Egri, Balázs Virágh, Dániel Horváth, and Imre M. Jánosi

Subjects
Medicine, Science
Abstract

Abstract The mature inflorescence of sunflowers (Helianthus annuus) orients eastward after its anthesis (the flowering period, especially the maturing of the stamens), from which point it no longer tracks the Sun. Although several hypothetical explanations have been proposed for the ecological functions of this east facing, none have been tested. Here we propose an atmospheric-optical explanation. Using (i) astronomical data of the celestial motion of the Sun, (ii) meteorological data of diurnal cloudiness for Boone County located in the region from which domesticated sunflowers originate, (iii) time-dependent elevation angle of mature sunflower heads, and (iv) absorption spectra of the inflorescence and the back of heads, we computed the light energy absorbed separately by the inflorescence and the back between anthesis and senescence. We found that the inflorescences facing east absorb the maximum radiation, being advantageous for seed production and maturation, furthermore west facing would be more advantageous than south facing. The reason for these is that afternoons are cloudier than mornings in the cultivation areas of sunflowers. Since the photosynthesizing green back of mature heads absorbs maximal energy when the inflorescence faces west, maximizing the energy absorbed by the back cannot explain the east facing of inflorescences. The same results were obtained for central Italy and Hungary, where mornings are also less cloudy than afternoons. In contrast, in south Sweden, where mornings are cloudier than afternoons, west-facing mature inflorescences would absorb the maximum light energy. We suggest that the domesticated Helianthus annuus developed an easterly final orientation of its mature inflorescence, because it evolved in a region with cloudier afternoons.

Published
2020
Full Text
View/download PDF

17. How the morning-afternoon cloudiness asymmetry affects the energy-maximizing azimuth direction of fixed-tilt monofacial solar panels

Author

Péter Takács, Judit Slíz-Balogh, Ákos Horváth, Dániel Horváth, Imre M. Jánosi, and Gábor Horváth

Subjects
fixed-tilt solar panel, monofacial photovoltaics, solar energy, clouds, Science
Abstract

In the Northern Hemisphere, south is the conventional azimuth direction of fixed-tilt monofacial solar panels, because this orientation may maximize the received light energy. How does the morning-afternoon cloudiness asymmetry affect the energy-maximizing azimuth direction of such solar panels? Prompted by this question, we calculated the total light energy received by a fixed-tilt monofacial solar panel in a whole year, using the celestial motion of the Sun and the direct and diffuse radiation measured hourly throughout the year in three North American (Boone County, Tennessee, Georgia) and European (Italy, Hungary, Sweden) regions. Here we show that, depending on the tilt angle and the local cloudiness conditions, the energy-maximizing ideal azimuth of a solar panel more or less turns eastward from south, if afternoons are cloudier than mornings in a yearly average. In certain cases, the turn of the ideal azimuth of such solar panels may be worth taking into consideration, even though the maximum energy gain is not larger than 5% for nearly vertical panels. Specifically, when solar panels are fixed on vertical walls or oblique roofs with non-ideal tilt, the deviation of the energy-maximizing azimuth from the south can be incorporated in the design of buildings.

Published
2022
Full Text
View/download PDF

21. Experimental access to Transition Distribution Amplitudes with the \={P}ANDA experiment at FAIR

Author

PANDA Collaboration, Singh, B. P., Erni, W., Keshelashvili, I., Krusche, B., M. Steinacher, Liu, B., Liu, H., Liu, Z., Shen, X., Wang, C., J. Zhao, Albrecht, M., Fink, M., Heinsius, F. H., Held, T., Holtmann, T., Koch, H., Kopf, B., Kümmel, M., Kuhl, G., Kuhlmann, M., Leyhe, M., Mikirtychyants, M., Musiol, P., Mustafa, A., Pelizäus, M., Pychy, J., Richter, M., Schnier, C., Schröder, T., Sowa, C., Steinke, M., Triffterer, T., Wiedner, U., Beck, R., Hammann, C., Kaiser, D., Ketzer, B., Kube, M., Mahlberg, P., Rossbach, M., Schmidt, C., Schmitz, R., Thoma, U., Walther, D., Wendel, C., Wilson, A., Bianconi, A., Bragadireanu, M., Caprini, M., Pantea, D., Pietreanu, D., Vasile, M. E., Patel, B., Kaplan, D., Brandys, P., Czyzewski, T., Czyzycki, W., Domagala, M., Hawryluk, M., Filo, G., Krawczyk, M., Kwiatkowski, D., Lisowski, E., Lisowski, F., Fiutowski, T., Idzik, M., Mindur, B., Przyborowski, D., Swientek, K., Czech, B., Kliczewski, S., Korcyl, K., Kozela, A., Kulessa, P., Lebiedowicz, P., Malgorzata, K., Pysz, K., Schäfer, W., Siudak, R., Szczurek, A., Biernat, J., Jowzaee, S., Kamys, B., Kistryn, S., Korcyl, G., Krzemien, W., Magiera, A., Moskal, P., Palka, M., Psyzniak, A., Rudy, Z., Salabura, P., Smyrski, J., Strzempek, P., Wrońska, A., Augustin, I., Lehmann, I., Nicmorus, D., Schepers, G., Schmitt, L., Al-Turany, M., Cahit, U., Capozza, L., Dbeyssi, A., Deppe, H., Dzhygadlo, R., Ehret, A., Flemming, H., Gerhardt, A., Götzen, K., Karabowicz, R., Kliemt, R., Kunkel, J., Kurilla, U., Lehmann, D., Lühning, J., Maas, F., Morales, C. Morales, Espí, M. C. Mora, Nerling, F., Orth, H., Peters, K., Pineiro, D. Rodríguez, Saito, N., Saito, T., Lorente, A. Sánchez, Schmidt, C. J., Schwarz, C., Schwiening, J., Traxler, M., Valente, R., Voss, B., Wieczorek, P., Wilms, A., Zühlsdorf, M., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Festchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevskiy, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, G. S., Skachkov, N. B., Skachkova, A. N., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopyanov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Glazier, D., Watts, D., Woods, P., Britting, A., Eyrich, W., Lehmann, A., Uhlig, F., Dobbs, S., Seth, K., Tomaradze, A., Xiao, T., Bettoni, D., Carassiti, V., Ramusino, A. Cotta, Dalpiaz, P., Drago, A., Fioravanti, E., Garzia, I., Savriè, M., Stancari, G., Akishina, V., Kisel, I., Kulakov, I., Zyzak, M., Arora, R., Bel, T., Gromliuk, A., Kalicy, G., Krebs, M., Patsyuk, M., Zuehlsdorf, M., Bianchi, N., Gianotti, P., Guaraldo, C., Lucherini, V., Pace, E., Bersani, A., Bracco, G., Macri, M., Parodi, R. F., Bianco, S., Bremer, D., Brinkmann, K. T., Diehl, S., Dormenev, V., Drexler, P., Düren, M., Eissner, T., Etzelmüller, E., Föhl, K., Galuska, M., Gessler, T., Gutz, E., Hayrapetyan, A., Hu, J., Kröck, B., Kühn, W., Kuske, T., Lange, S., Liang, Y., Merle, O., Metag, V., Mülhheim, D., Münchow, D., Nanova, M., Novotny, R., Pitka, A., Quagli, T., Rieke, J., Rosenbaum, C., Schnell, R., Spruck, B., Stenzel, H., Thöring, U., Ullrich, M., Wasem, T., Werner, M., Zaunick, H. G., Ireland, D., Rosner, G., Seitz, B., Deepak, P. N., Kulkarni, A. V., Apostolou, A., Babai, M., Kavatsyuk, M., Lemmens, P., Lindemulder, M., Löhner, H., Messchendorp, J., Schakel, P., Smit, H., van der Weele, J. C., Tiemens, M., Veenstra, R., Vejdani, S., Kalita, K., Mohanta, D. P., Kumar, A., Roy, A., Sahoo, R., Sohlbach, H., Büscher, M., Cao, L., Cebulla, A., Deermann, D., Dosdall, R., Esch, S., Georgadze, I., Gillitzer, A., Goerres, A., Goldenbaum, F., Grunwald, D., Herten, A., Hu, Q., Kemmerling, G., Kleines, H., Kozlov, V., Lehrach, A., Leiber, S., Maier, R., Nellen, R., Ohm, H., Orfanitski, S., Prasuhn, D., Prencipe, E., Ritman, J., Schadmand, S., Schumann, J., Sefzick, T., Serdyuk, V., Sterzenbach, G., Stockmanns, T., Wintz, P., Wüstner, P., Xu, H., Li, S., Li, Z., Sun, Z., Rigato, V., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schröder, B., Achenbach, P., Bleser, S., Cardinali, M., Corell, O., Deiseroth, M., Denig, A., Distler, M., Feldbauer, F., Fritsch, M., Jasinski, P., Hoek, M., Kangh, D., Karavdina, A., Lauth, W., Leithoff, H., Merkel, H., Michel, M., Motzko, C., Müller, U., Noll, O., Plueger, S., Pochodzalla, J., Sanchez, S., Schlimme, S., Sfienti, C., Steinen, M., Thiel, M., Weber, T., Zambrana, M., Dormenev, V. I., Fedorov, A. A., Korzihik, M. V., Missevitch, O. V., Balanutsa, P., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Varentsov, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Konorov, I., Paul, S., Grieser, S., Hergemöller, A. K., Khoukaz, A., Köhler, E., Täschner, A., Wessels, J., Dash, S., Jadhav, M., Kumar, S., Sarin, P., Varma, R., Chandratre, V. B., Datar, V., Dutta, D., Jha, V., Kumawat, H., Mohanty, A. K., Roy, B., Yan, Y., Chinorat, K., Khanchai, K., Ayut, L., Pornrad, S., Barnyakov, A. Y., Blinov, A. E., Blinov, V. E., Bobrovnikov, V. S., Kononov, S. A., Kravchenko, E. A., Kuyanov, I. A., Onuchin, A. P., Sokolov, A. A., Tikhonov, Y. A., Atomssa, E., Hennino, T., Imre, M., Kunne, R., Galliard, C. Le, Ma, B., Marchand, D., Ong, S., Ramstein, B., Rosier, P., Tomasi-Gustafsson, E., Van de Wiele, J., Boca, G., Costanza, S., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Abramov, V., Belikov, N., Bukreeva, S., Davidenko, A., Derevschikov, A., Goncharenko, Y., Grishin, V., Kachanov, V., Kormilitsin, V., Melnik, Y., Levin, A., Minaev, N., Mochalov, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Yabsley, B., Bäck, T., Cederwall, B., Makónyi, K., Tegnér, P. E., von Würtemberg, K. M., Belostotski, S., Gavrilov, G., Izotov, A., Kashchuk, A., Levitskaya, O., Manaenkov, S., Miklukho, O., Naryshkin, Y., Suvorov, K., Veretennikov, D., Zhadanov, A., Rai, A. K., Godre, S. S., Duchat, R., Amoroso, A., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Fava, L., Ferrero, L., Greco, M., Maggiora, M., Maniscalco, G., Marcello, S., Sosio, S., Spataro, S., Zotti, L., Calvo, D., Coli, S., De Remigis, P., Filippi, A., Giraudo, G., Lusso, S., Mazza, G., Mingnore, M., Rivetti, A., Wheadon, R., Balestra, F., Iazzi, F., Introzzi, R., Lavagno, A., Younis, H., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Gålnander, B., Balkeståhl, L. Caldeira, Calén, H., Fransson, K., Johansson, T., Kupsc, A., Marciniewski, P., Pettersson, J., Schönning, K., Wolke, M., Zlomanczuk, J., Díaz, J., Ortiz, A., Vinodkumar, P. C., Parmar, A., Chlopik, A., Melnychuk, D., Slowinski, B., Trzcinski, A., Wojciechowski, M., Wronka, S., Zwieglinski, B., Bühler, P., Marton, J., Suzuki, K., Widmann, E., Zmeskal, J., Fröhlich, B., Khaneft, D., Lin, D., Zimmermann, I., and Semenov-Tian-Shansky, K.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

Baryon-to-meson Transition Distribution Amplitudes (TDAs) encoding valuable new information on hadron structure appear as building blocks in the collinear factorized description for several types of hard exclusive reactions. In this paper, we address the possibility of accessing nucleon-to-pion ($\pi N$) TDAs from $\bar{p}p \to e^+e^- \pi^0$ reaction with the future \={P}ANDA detector at the FAIR facility. At high center of mass energy and high invariant mass squared of the lepton pair $q^2$, the amplitude of the signal channel $\bar{p}p \to e^+e^- \pi^0$ admits a QCD factorized description in terms of $\pi N$ TDAs and nucleon Distribution Amplitudes (DAs) in the forward and backward kinematic regimes. Assuming the validity of this factorized description, we perform feasibility studies for measuring $\bar{p}p \to e^+e^- \pi^0$ with the \={P}ANDA detector. Detailed simulations on signal reconstruction efficiency as well as on rejection of the most severe background channel, i.e. $\bar{p}p \to \pi^+\pi^- \pi^0$ were performed for the center of mass energy squared $s = 5$ GeV$^2$ and $s = 10$ GeV$^2$, in the kinematic regions $3.0 < q^2 < 4.3$ GeV$^2$ and $5 < q^2 < 9$ GeV$^2$, respectively, with a neutral pion scattered in the forward or backward cone $| \cos\theta_{\pi^0}| > 0.5 $ in the proton-antiproton center of mass frame. Results of the simulation show that the particle identification capabilities of the \={P}ANDA detector will allow to achieve a background rejection factor of $5\cdot 10^7$ ($1\cdot 10^7$) at low (high) $q^2$ for $s=5$ GeV$^2$, and of $1\cdot 10^8$ ($6\cdot 10^6$) at low (high) $q^2$ for $s=10$ GeV$^2$, while keeping the signal reconstruction efficiency at around $40\%$. At both energies, a clean lepton signal can be reconstructed with the expected statistics corresponding to $2$ fb$^{-1}$ of integrated luminosity. (.../...), Comment: 19 pages, 7 figures (some multiple), 2 tables (each double), preprint of an article for epj - v2

Published
2014

22. Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts

Author

Dávid Kovács, Nóra Igaz, Annamária Marton, Andrea Rónavári, Péter Bélteky, László Bodai, Gabriella Spengler, László Tiszlavicz, Zsolt Rázga, Péter Hegyi, Csaba Vizler, Imre M. Boros, Zoltán Kónya, and Mónika Kiricsi

Subjects
Core–shell nanoparticles, Tumour stroma, Cancer-associated fibroblasts, Metastasis, RNA sequencing, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5
Abstract

Abstract Background Although accumulating evidence suggests that the crosstalk between malignant cells and cancer-associated fibroblasts (CAFs) actively contributes to tumour growth and metastatic dissemination, therapeutic strategies targeting tumour stroma are still not common in the clinical practice. Metal-based nanomaterials have been shown to exert excellent cytotoxic and anti-cancerous activities, however, their effects on the reactive stroma have never been investigated in details. Thus, using feasible in vitro and in vivo systems to model tumour microenvironment, we tested whether the presence of gold, silver or gold-core silver-shell nanoparticles exerts anti-tumour and metastasis suppressing activities by influencing the tumour-supporting activity of stromal fibroblasts. Results We found that the presence of gold-core silver-shell hybrid nanomaterials in the tumour microenvironment attenuated the tumour cell-promoting behaviour of CAFs, and this phenomenon led to a prominent attenuation of metastatic dissemination in vivo as well. Mechanistically, transcriptome analysis on tumour-promoting CAFs revealed that silver-based nanomaterials trigger expressional changes in genes related to cancer invasion and tumour metastasis. Conclusions Here we report that metal nanoparticles can influence the cancer-promoting activity of tumour stroma by affecting the gene expressional and secretory profiles of stromal fibroblasts and thereby altering their intrinsic crosstalk with malignant cells. This potential of metal nanomaterials should be exploited in multimodal treatment approaches and translated into improved therapeutic outcomes.

Published
2020
Full Text
View/download PDF

24. Evolutionary mode for the functional preservation of fast-evolving Drosophila telomere capping proteins

Author

Balázs Vedelek, Ákos Kovács, and Imre M. Boros

Subjects
Terminin, fast evolution, Ob-fold, Ver, Moi, DTL, Biology (General), QH301-705.5
Abstract

DNA end protection is fundamental for the long-term preservation of the genome. In vertebrates the Shelterin protein complex protects telomeric DNA ends, thereby contributing to the maintenance of genome integrity. In the Drosophila genus, this function is thought to be performed by the Terminin complex, an assembly of fast-evolving subunits. Considering that DNA end protection is fundamental for successful genome replication, the accelerated evolution of Terminin subunits is counterintuitive, as conservation is supposed to maintain the assembly and concerted function of the interacting partners. This problem extends over Drosophila telomere biology and provides insight into the evolution of protein assemblies. In order to learn more about the mechanistic details of this phenomenon we have investigated the intra- and interspecies assemblies of Verrocchio and Modigliani, two Terminin subunits using in vitro assays. Based on our results and on homology-based three-dimensional models for Ver and Moi, we conclude that both proteins contain Ob-fold and contribute to the ssDNA binding of the Terminin complex. We propose that the preservation of Ver function is achieved by conservation of specific amino acids responsible for folding or localized in interacting surfaces. We also provide here the first evidence on Moi DNA binding.

Published
2021
Full Text
View/download PDF

25. Technical Design Report for the: PANDA Micro Vertex Detector

Author

PANDA Collaboration, Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, Q., Xu, H., Albrecht, M., Becker, J., Eickel, K., Feldbauer, F., Fink, M., Friedel, P., Heinsius, F. H., Held, T., Koch, H., Kopf, B., Leyhe, M., Motzko, C., Pelizäus, M., Pychy, J., Roth, B., Schröder, T., Schulze, J., Steinke, M., Trifterer, T., Wiedner, U., Zhong, J., Beck, R., Becker, M., Bianco, S., Brinkmann, K. -Th., Hammann, C., Hinterberger, F., Jäkel, R., Kaiser, D., Kliemt, R., Koop, K., Schmidt, C., Schnell, R., Thoma, U., Vlasov, P., Wendel, C., Winnebeck, A., Würschig, Th., Zaunick, H. -G., Bianconi, A., Bragadireanu, M., Caprini, M., Ciubancan, M., Pantea, D., Tarta, P. -D, De Napoli, M., Giacoppo, F., Rapisarda, E., Sfienti, C., Fiutowski, T., Idzik, N., Mindur, B., Przyborowski, D., Swientek, K., Bialkowski, E., Budzanowski, A., Czech, B., Kliczewski, S., Kozela, A., Kulessa, P., Lebiedowicz, P., Malgorzata, K., Pysz, K., Schäfer, W., Siudak, R., Szczurek, A., Brandys, P., Czyzewski, T., Czyzycki, W., Domagala, M., Hawryluk, M., Filo, G., Kwiatkowski, D., Lisowski, E., Lisowski, F., Bardan, W., Gil, D., Kamys, B., Kistryn, St., Korcyl, K., Krzemieñ, W., Magiera, A., Moskal, P., Rudy, Z., Salabura, P., Smyrski, J., Wroñska, A., Al-Turany, M., Arora, R., Augustin, I., Deppe, H., Dutta, D., Flemming, H., Götzen, K., Hohler, G., Karabowicz, R., Lehmann, D., Lewandowski, B., Lühning, J., Maas, F., Orth, H., Peters, K., Saito, T., Schepers, G., Schmidt, C. J., Schmitt, L., Schwarz, C., Schwiening, J., Voss, B., Wieczorek, P., Wilms, A., Abazov, V. M., Alexeev, G. D., Arefiev, V. A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Feshchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevski, A. G., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopyanov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Glazier, D., Watts, D., Woods, P., Britting, A., Eyrich, W., Lehmann, A., Uhlig, F., Dobbs, S., Metreveli, Z., Seth, K., Tann, B., Tomaradze, A., Bettoni, D., Carassiti, V., Dalpiaz, P., Drago, A., Fioravanti, E., Garzia, I., Negrini, M., Savriè, M., Stancari, G., Dulach, B., Gianotti, P., Guaraldo, C., Lucherini, V., Pace, E., Bersani, A., Macri, M., Marinelli, M., Parodi, R. F., Dormenev, V., Drexler, P., Düren, M., Eisner, T., Foehl, K., Hayrapetyan, A., Koch, P., Krïoch, B., Kühn, W., Lange, S., Liang, Y., Liu, M., Merle, O., Metag, V., Moritz, M., Nanova, M., Novotny, R., Spruck, B., Stenzel, H., Strackbein, C., Thiel, M., Clarkson, T., Euan, C., Hill, G., Hoek, M., Ireland, D., Kaiser, R., Keri, T., Lehmann, I., Livingston, K., Lumsden, P., MacGregor, D., McKinnon, B., Montgomery, R., Murray, M., Protopopescu, D., Rosner, G., Seitz, B., Yang, G., Babai, M., Biegun, A. K., Glazenborg-Kluttig, A., Guliyev, E., Jothi, V. S., Kavatsyuk, M., Lemmens, P., Löhner, H., Messchendorp, J., Poelman, T., Smit, H., van der Weele, J. C., Sohlbach, H., Büscher, M., Dosdall, R., Dzhygadlo, R., Esch, S., Gillitzer, A., Goldenbaum, F., Grunwald, D., Jha, V., Kemmerling, G., Kleines, H., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Pohl, D. L., Prasuhn, D., Randriamalala, T., Ritman, J., Roeder, M., Sterzenbach, G., Stockmanns, T., Wintz, P., Wüstner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Fissum, K., Hansen, K., Isaksson, L., Lundin, M., Schröder, B., Achenbach, P., Denig, A., Distler, M., Fritsch, M., Kangh, D., Karavdina, A., Lauth, W., Michel, M., Espi, M. C. Mora, Pochodzalla, J., Sanchez, S., Sanchez-Lorente, A., Weber, T., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Varma, R., Ketzer, B., Konorov, I., Mann, A., Neubert, S., Paul, S., Vandenbroucke, M., Zhang, Q., Khoukaz, A., Rausmann, T., Täschner, A., Wessels, J., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Hennino, T., Imre, M., Kunne, R., Galliard, C. Le, Normand, J. P. Le, Marchand, D., Maroni, A., Ong, S., Pouthas, J., Ramstein, B., Rosier, P., Sudol, M., Theneau, C., Tomasi-Gustafsson, E., Van de Wiele, J., Zerguerras, T., Boca, G., Braghieri, A., Costanza, S., Fontana, A., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Buda, V., Abramov, V. V., Davidenko, A. M., Derevschikov, A. A., Goncharenko, Y. M., Grishin, V. N., Kachanov, V. A., Konstantinov, D. A., Kormilitsin, V. A., Matulenko, Y. A., Melnik, Y. M., Meschanin, A. P., Minaev, N. G., Mochalov, V. V., Morozov, D. A., Nogach, L. V., Nurushev, S. B., Ryazantsev, A. V., Semenov, P. A., Soloviev, L. F., Uzunian, A. V., Vasiliev, A. N., Yakutin, A. E., Belostotski, S., Gavrilov, G., Itzotov, A., Kisselev, A., Kravchenko, P., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Bäck, T., Cederwall, B., Bargholtz, C., Gerén, L., Tegnér, P. E., Thørngren, P., von Würtemberg, K. M., Fava, L., Alberto, D., Amoroso, A., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Ferrero, L., Greco, M., Kugathasan, T., Maggiora, M., Marcello, S., Sosio, S., Spataro, S., Calvo, D., Coli, S., De Remigis, P., Filippi, A., Giraudo, G., Lusso, S., Mazza, G., Mignone, M., Rivetti, A., Wheadon, R., Zotti, L., Morra, O., Iazzi, F., Lavagno, A., Quarati, P., Szymanska, K., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Galnander, B., Calén, H., Fransson, K., Johansson, T., Kupsc, A., Marciniewski, P., Thomé, E., Wolke, M., Zlomanczuk, J., Díaz, J., Ortiz, A., Buda, P., Dmowski, K., Korzeniewski, R., Przemyslaw, D., Slowinski, B., Borsuk, S., Chlopik, A., Guzik, Z., Kopec, J., Kozlowski, T., Melnychuk, D., Plominski, M., Szewinski, J., Traczyk, K., Zwieglinski, B., Bühler, P., Gruber, A., Kienle, P., Marton, J., Widmann, E., and Zmeskal, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

This document illustrates the technical layout and the expected performance of the Micro Vertex Detector (MVD) of the PANDA experiment. The MVD will detect charged particles as close as possible to the interaction zone. Design criteria and the optimisation process as well as the technical solutions chosen are discussed and the results of this process are subjected to extensive Monte Carlo physics studies. The route towards realisation of the detector is outlined., Comment: 189 pages, 225 figures, 41 tables

Published
2012

26. Technical Design Report for the: PANDA Straw Tube Tracker

Author

PANDA Collaboration, Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, Q., Xu, H., Aab, A., Albrecht, M., Becker, J., Csapó, A., Feldbauer, F., Fink, M., Friedel, P., Heinsius, F. H., Held, T., Klask, L., Koch, H., Kopf, B., Leiber, S., Leyhe, M., Motzko, C., Pelizäus, M., Pychy, J., Roth, B., Schröder, T., Schulze, J., Sowa, C., Steinke, M., Trifterer, T., Wiedner, U., Zhong, J., Beck, R., Bianco, S., Brinkmann, K. T., Hammann, C., Hinterberger, F., Kaiser, D., Kliemt, R., Kube, M., Pitka, A., Quagli, T., Schmidt, C., Schmitz, R., Schnell, R., Thoma, U., Vlasov, P., Walther, D., Wendel, C., Würschig, T., Zaunick, H. G., Bianconi, A., Bragadireanu, M., Caprini, M., Pantea, D., Pantelica, D., Pietreanu, D., Serbina, L., Tarta, P. D., Kaplan, D., Fiutowski, T., Idzik, M., Mindur, B., Przyborowski, D., Swientek, K., Czech, B., Kistryn, M., Kliczewski, S., Kozela, A., Kulessa, P., Lebiedowicz, P., Pysz, K., Schäfer, W., Siudak, R., Szczurek, A., Jowzaee, S., Kajetanowicz, M., Kamys, B., Kistryn, S., Korcyl, G., Korcyl, K., Krzemien, W., Magiera, A., Moskal, P., Palka, M., Rudy, Z., Salabura, P., Smyrski, J., Wrońska, A., Augustin, I., Lehmann, I., Nimorus, D., Schepers, G., Al-Turany, M., Arora, R., Deppe, H., Flemming, H., Gerhardt, A., Götzen, K., Jordi, A. F., Kalicy, G., Karabowicz, R., Lehmann, D., Lewandowski, B., Lühning, J., Maas, F., Orth, H., Patsyuk, M., Peters, K., Saito, T., Schmidt, C. J., Schmitt, L., Schwarz, C., Schwiening, J., Traxler, M., Voss, B., Wieczorek, P., Wilms, A., Zühlsdorf, M., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Festchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevskiy, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopyanov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Glazier, D., Watts, D., Woods, P., Britting, A., Eyrich, W., Lehmann, A., Uhlig, F., Dobbs, S., Metreveli, Z., Seth, K., Tomaradze, A., Xiao, T., Bettoni, D., Carassiti, V., Ramusino, A. Cotta, Dalpiaz, P., Drago, A., Fioravanti, E., Garzia, I., Savriè, M., Stancari, G., Bianchi, N., Gianotti, P., Guaraldo, C., Lucherini, V., Orecchini, D., Pace, E., Bersani, A., Bracco, G., Macri, M., Parodi, R. F., Bremer, D., Dormenev, V., Drexler, P., Düren, M., Eissner, T., Föhl, K., Galuska, M., Gessler, T., Hayrapetyan, A., Hu, J., Koch, P., Kröck, B., Kühn, W., Lange, S., Liang, Y., Merle, O., Metag, V., Moritz, M., Münchow, D., Nanova, M., Novotny, R., Spruck, B., Stenzel, H., Ullrich, T., Werner, M., Euan, C., Hoek, M., Ireland, D., Keri, T., Montgomery, R., Protopopescu, D., Rosner, G., Seitz, B., Babai, M., Glazenborg-Kluttig, A., Kavatsyuk, M., Lemmens, P., Lindemulder, M., Löhner, H., Messchendorp, J., Moeini, H., Schakel, P., Schreuder, F., Smit, H., Tambave, G., van der Weele, J. C., Veenstra, R., Sohlbach, H., Büscher, M., Deermann, D., Dosdall, R., Esch, S., Gillitzer, A., Goldenbaum, F., Grunwald, D., Henssler, S., Herten, A., Hu, Q., Kemmerling, G., Kleines, H., Kozlov, V., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Orfanitski, S., Prasuhn, D., Randriamalala, T., Ritman, J., Schadmand, S., Serdyuk, V., Sterzenbach, G., Stockmanns, T., Wintz, P., Wüstner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Rigato, V., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schröder, B., Achenbach, P., Bleser, S., Cahit, U., Cardinali, M., Denig, A., Distler, M., Fritsch, M., Kangh, D., Karavdina, A., Lauth, W., Merkel, H., Michel, M., Espi, M. C. Mora, Müller, U., Pochodzalla, J., Prometeusz, J., Sanchez, S., Sanchez-Lorente, A., Schlimme, S., Sfienti, C., Thiel, M., Weber, T., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Varentsov, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Böhmer, F., Dørheim, S., Ketzer, B., Paul, S., Hergemöller, A. K., Khoukaz, A., Köhler, E., Täschner, A., Wessels, J., Varma, R., Chaterjee, A., Jha, V., Kailas, S., Roy, B., Yan, Y., Chinorat, K., Khanchai, K., Ayut, L., Pomrad, S., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Boucher, J., Chambert, V., Dbeyssi, A., Hennino, T., Imre, M., Kunne, R., Galliard, C. Le, Ma, B., Marchand, D., Maroni, A., Ong, S., Ramstein, B., Rosier, P., Sudol, M., Tomasi-Gustafsson, E., Van de Wiele, J., Boca, G., Braghieri, A., Costanza, S., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Abramov, V., Belikov, N., Davidenko, A., Derevschikov, A., Goncharenko, Y., Grishin, V., Kachanov, V., Konstantinov, D., Kormilitsin, V., Melnik, Y., Levin, A., Minaev, N., Mochalov, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Bäck, T., Cederwall, B., Makónyi, K., Tegnér, P. E., von Würtemberg, K. M., Belostotski, S., Gavrilov, G., Itzotov, A., Kashchuk, A., Kisselev, A., Kravchenko, P., Levitskaya, O., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Alberto, D., Amoroso, A., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Fava, L., Ferrero, L., Greco, M., Maggiora, M., Marcello, S., Sosio, S., Spataro, S., Zotti, L., Calvo, D., Coli, S., De Remigis, P., Filippi, A., Giraudo, G., Lusso, S., Mazza, G., Morra, O., Rivetti, A., Wheadon, R., Iazzi, F., Lavagno, A., Younis, H., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Galander, B., Balkeståhl, L. Caldeira, Calén, H., Fransson, K., Johansson, T., Kupsc, A., Marciniewski, P., Thomé, E., Wolke, M., Zlomanczuk, J., Díaz, J., Ortiz, A., Dmowski, K., Duda, P., Korzeniewski, R., Slowinski, B., Chlopik, A., Guzik, Z., Kosinski, K., Melnychuk, D., Wasilewski, A., Wojciechowski, M., Wronka, S., Wysocka, A., Zwieglinski, B., Bühler, P., Hartman, O., Kienle, P., Marton, J., Suzuki, K., Widmann, E., and Zmeskal, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This document describes the technical layout and the expected performance of the Straw Tube Tracker (STT), the main tracking detector of the PANDA target spectrometer. The STT encloses a Micro-Vertex-Detector (MVD) for the inner tracking and is followed in beam direction by a set of GEM-stations. The tasks of the STT are the measurement of the particle momentum from the reconstructed trajectory and the measurement of the specific energy-loss for a particle identification. Dedicated simulations with full analysis studies of certain proton-antiproton reactions, identified as being benchmark tests for the whole PANDA scientific program, have been performed to test the STT layout and performance. The results are presented, and the time lines to construct the STT are described., Comment: accepted for publication on EPJA

Published
2012
Full Text
View/download PDF

28. Predictive Potential of RNA Polymerase B (II) Subunit 1 (RPB1) Cytoplasmic Aggregation for Neoadjuvant Chemotherapy Failure

Author

Nagy-Mikó, Bence, primary, Németh-Szatmári, Orsolya, additional, Faragó-Mészáros, Réka, additional, Csókási, Aliz, additional, Bognár, Bence, additional, Ördög, Nóra, additional, Borsos, Barbara N., additional, Majoros, Hajnalka, additional, Ujfaludi, Zsuzsanna, additional, Oláh-Németh, Orsolya, additional, Nikolényi, Aliz, additional, Dobi, Ágnes, additional, Kószó, Renáta, additional, Sántha, Dóra, additional, Lázár, György, additional, Simonka, Zsolt, additional, Paszt, Attila, additional, Ormándi, Katalin, additional, Pankotai, Tibor, additional, Boros, Imre M., additional, Villányi, Zoltán, additional, and Vörös, András, additional

Published
2023
Full Text
View/download PDF

29. The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo

Author

Paula Climent-Cantó, Albert Carbonell, Srividya Tamirisa, Laszlo Henn, Salvador Pérez-Montero, Imre M. Boros, and Fernando Azorín

Subjects
linker histone H1, dBigH1, Brat, oogenesis, embryogenesis, Drosophila, Biology (General), QH301-705.5
Abstract

Linker histones H1 are essential chromatin components that exist as multiple developmentally regulated variants. In metazoans, specific H1s are expressed during germline development in a tightly regulated manner. However, the mechanisms governing their stage-dependent expression are poorly understood. Here, we address this question in Drosophila, which encodes for a single germline-specific dBigH1 linker histone. We show that during female germline lineage differentiation, dBigH1 is expressed in germ stem cells and cystoblasts, becomes silenced during transit-amplifying (TA) cystocytes divisions to resume expression after proliferation stops and differentiation starts, when it progressively accumulates in the oocyte. We find that dBigH1 silencing during TA divisions is post-transcriptional and depends on the tumour suppressor Brain tumour (Brat), an essential RNA-binding protein that regulates mRNA translation and stability. Like other oocyte-specific variants, dBigH1 is maternally expressed during early embryogenesis until it is replaced by somatic dH1 at the maternal-to-zygotic transition (MZT). Brat also mediates dBigH1 silencing at MZT. Finally, we discuss the situation in testes, where Brat is not expressed, but dBigH1 is translationally silenced too.

Published
2021
Full Text
View/download PDF

30. The central neutron detector for CLAS12

Author

Niccolai, S., Hull, G., Bettane, J., Chatagnon, P., Garillon, B., Genolini, B., Guegan, B., Guidal, M., Imre, M., Josselin, M., Marchand, D., Maroni, A., Mathon, B., Murdoch, G., Trung, T. Nguyen, Peyré, J., Pouthas, J., Rosier, P., Sokhan, D., Theneau, C., and Wang, R.

Published
2018
Full Text
View/download PDF

31. Production and electromagnetic decay of hyperons: a feasibility study with HADES as a phase-0 experiment at FAIR

Author

Adamczewski-Musch, J., Belyaev, A., Blanco, A., Blume, C., Charlotte, C., Borisenko, D. S., Charlotte, C., Chlad, L., Chudoba, P., Ciepał, I., Derichs, A., Dittert, D., Dreyer, J., Esmail, W., Fateev, O., Fonte, P., Friese, J., Fröhlich, I., Förtsch, J., Galatyuk, T., Georgadze, I., Golosov, O., Golubeva, M., Greifenhagen, R., Grunwald, M., Grzonka, D., Guber, F., Gumberidze, M., Harabasz, S., Heinz, T., Heybeck, B., Höhne, C., Holona, M., Holzmann, R., Huck, H., Ierusalimov, A., Imre, M., Ivashkin, A., Kämpfer, B., Kampert, K-H., Kardan, B., Kedych, V., Khomyakov, V., Koenig, I., Koenig, W., Kohls, M., Kornakov, G., Kornas, F., Kotte, R., Kozela, A., Kozlov, V., Kres, I., Kuboś, J., Kugler, A., Kulessa, P., Ladygin, V., Lalik, R., Le Galliard, C., Lebedev, A., Lebedev, S., Linev, S., Lopes, L., Lorenz, M., Lykasov, G., Malige, A., Markert, J., Matulewicz, T., Michel, J., Morozov, S., Müntz, C., Naumann, L., Nowakowski, K., Orfanitsky, S., Otto, J. -H., Patel, V., Pauly, C., Pechenov, V., Pechenova, O., Perez Andrade, G., Petukhov, O., Pfeifer, D., Piasecki, K., Pietraszko, J., Prozorov, A., Przygoda, W., Pysz, K., Ramstein, B., Rathod, N., Regina, J., Reshetin, A., Reznikov, S., Rieger, J. T., Ritman, J., Rodriguez-Ramos, P., Rost, A., Rustamov, A., Salabura, P., Saraiva, J., Schild, N., Schwab, E., Schönning, K., Scozzi, F., Seck, F., Selyuzhenkov, I., Serdyuk, V., Shabanov, A., Singh, U., Smyrski, J., Sobiella, M., Spies, S., Strikhanov, M., Ströbele, H., Stroth, J., Sumara, K., Svoboda, O., Szala, M., Szewczyk, J., Taranenko, A., Tlusty, P., Traxler, M., Wagner, V., Wasiluk, M., Weber, A. A., Wendisch, C., Wintz, P., Włoch, B., Zbroszczyk, H. P., Zherebzova, E., Zhilin, A., Zinchenko, A., and Zumbruch, P.

Published
2021
Full Text
View/download PDF

32. Detrended fluctuation analysis of daily temperature records: Geographic dependence over Australia

Author

Király, Andrea and Jánosi, Imre M.

Subjects
Physics - Atmospheric and Oceanic Physics, Physics - Data Analysis, Statistics and Probability
Abstract

Daily temperature anomaly records are analyzed (61 for Australia, 18 for Hungary) by means of detrended fluctuation analysis. Positive long range asymptotic correlations extending up to 5-10 years are detected for each case. Contrary to earlier claims, the correlation exponent is not universal for continental stations. Interestingly, the dominant factor is geographic latitude over Australia: the general tendency is a decrease of correlation exponent with increasing distance from the equator. This tendency is in a complete agreement with the results found by Tsonis et al. (1999) for 500-hPa height anomalies in the northern hemisphere. The variance of fluctuations exhibits an opposite trend, the larger is the distance from the equator, the larger the amplitude of intrinsic fluctuations. The presence of Tropospheric Biennial Oscillation is clearly identified for three stations at the north-eastern edge of the Australian continent., Comment: accepted for publication in Meteorology and Atmopsheric Physics

Published
2004
Full Text
View/download PDF

33. Growth and Characterization of Graphene Layers on Different Kinds of Copper Surfaces

Author

Peter M. Rafailov, Peter K. Sveshtarov, Vladimir B. Mehandzhiev, Ivalina Avramova, Penka Terziyska, Minko Petrov, Boyko Katranchev, Haritun Naradikian, Stefan I. Boyadjiev, Csaba Cserháti, Zoltán Erdélyi, and Imre M. Szilágyi

Subjects
graphene, chemical vapor deposition, Raman spectroscopy, X-ray photoelectron spectroscopy, ellipsometry, electron backscatter diffraction, Organic chemistry, QD241-441
Abstract

Graphene films were grown by chemical vapor deposition on Cu foil. The obtained samples were characterized by Raman spectroscopy, ellipsometry, X-ray photoelectron spectroscopy and electron back-scatter diffraction. We discuss the time-dependent changes in the samples, estimate the thickness of emerging Cu2O beneath the graphene and check the orientation-dependent affinity to oxidation of distinct Cu grains, which also governs the manner in which the initial strong Cu-graphene coupling and strain in the graphene lattice is released. Effects of electropolishing on the quality and the Raman response of the grown graphene layers are studied by microtexture polarization analysis. The obtained data are compared with the Raman signal of graphene after transfer on glass substrate revealing the complex interaction of graphene with the Cu substrate.

Published
2022
Full Text
View/download PDF

37. Analysis of Drosophila melanogaster testis transcriptome

Author

Viktor Vedelek, László Bodai, Gábor Grézal, Bence Kovács, Imre M. Boros, Barbara Laurinyecz, and Rita Sinka

Subjects
Drosophila, Transcriptome, RNA sequencing, Testis, Spermatogenesis, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background The formation of matured and individual sperm involves a series of molecular and spectacular morphological changes of the developing cysts in Drosophila melanogaster testis. Recent advances in RNA Sequencing (RNA-Seq) technology help us to understand the complexity of eukaryotic transcriptomes by dissecting different tissues and developmental stages of organisms. To gain a better understanding of cellular differentiation of spermatogenesis, we applied RNA-Seq to analyse the testis-specific transcriptome, including coding and non-coding genes. Results We isolated three different parts of the wild-type testis by dissecting and cutting the different regions: 1.) the apical region, which contains stem cells and developing spermatocytes 2.) the middle region, with enrichment of meiotic cysts 3.) the basal region, which contains elongated post-meiotic cysts with spermatids. Total RNA was isolated from each region and analysed by next-generation sequencing. We collected data from the annotated 17412 Drosophila genes and identified 5381 genes with significant transcript accumulation differences between the regions, representing the main stages of spermatogenesis. We demonstrated for the first time the presence and region specific distribution of 2061 lncRNAs in testis, with 203 significant differences. Using the available modENCODE RNA-Seq data, we determined the tissue specificity indices of Drosophila genes. Combining the indices with our results, we identified genes with region-specific enrichment in testis. Conclusion By multiple analyses of our results and integrating existing knowledge about Drosophila melanogaster spermatogenesis to our dataset, we were able to describe transcript composition of different regions of Drosophila testis, including several stage-specific transcripts. We present searchable visualizations that can facilitate the identification of new components that play role in the organisation and composition of different stages of spermatogenesis, including the less known, but complex regulation of post-meiotic stages.

Published
2018
Full Text
View/download PDF

38. Coordinated activation of a cluster of MMP genes in response to UVB radiation

Author

Zsuzsanna Ujfaludi, Agota Tuzesi, Hajnalka Majoros, Balint Rothler, Tibor Pankotai, and Imre M. Boros

Subjects
Medicine, Science
Abstract

Abstract Ultraviolet (UV) B radiation is a dangerous environmental stressor, which can lead to photoaging, inflammation, immune suppression and tumour formation. A recent report has shown the transcriptional activation of several skin-specific genes including matrix metalloproteases (MMPs) in response to UV irradiation. Here, we use a novel human keratinocyte model, HKerE6SFM, to demonstrate that UVB activates the transcription of most members of the 11q22.3 MMP gene cluster including MMP13, MMP12, MMP3, MMP1 and MMP10. Curiously, the expression of the well-characterized UVB-inducible MMP9, which is located outside of the cluster, remains unchanged. In accordance with the increased expression of the MMP gene cluster upon UVB irradiation, RNA polymerase II showed increased occupancy at their promoters following UVB irradiation. The results also demonstrate increased acetylated histone H3K9 levels at the promoters of the MMP13, MMP12, MMP3, MMP1 and MMP10 genes. These findings suggest a coordinated transcriptional activation of genes in the MMP cluster at 11q22.3 and that acetylation of histone H3 at lysine 9 has an important role in the UVB-dependent enhancement of transcription of MMP genes in this region.

Published
2018
Full Text
View/download PDF

39. Phase-separated ribosome-nascent chain complexes in genotoxic stress response

Author

Németh-Szatmári, Orsolya, primary, Nagy-Mikó, Bence, additional, Györkei, Ádám, additional, Varga, Dániel, additional, Kovács, Bálint Barna H., additional, Igaz, Nóra, additional, Bognár, Bence, additional, Rázga, Zsolt, additional, Nagy, Gábor, additional, Zsindely, Nóra, additional, Bodai, László, additional, Papp, Balázs, additional, Erdélyi, Miklós, additional, Kiricsi, Mónika, additional, Blastyák, András, additional, Collart, Martine A., additional, Boros, Imre M., additional, and Villányi, Zoltán, additional

Published
2023
Full Text
View/download PDF

45. Anomalous density dependence of static friction in sand

Author

Horváth, Viktor K., Jánosi, Imre M., and Vella, Péter J.

Subjects
Condensed Matter, Physics - Classical Physics
Abstract

We measured experimentally the static friction force $F_s$ on the surface of a glass rod immersed in dry sand. We observed that $F_s$ is extremely sensitive to the closeness of packing of grains. A linear increase of the grain-density yields to an exponentially increasing friction force. We also report on a novel periodicity of $F_s$ during gradual pulling out of the rod. Our observations demonstrate the central role of grain bridges and arches in the macroscopic properties of granular packings., Comment: plain tex, 6 pages, to appear in Phys.Rev.E

Published
1996
Full Text
View/download PDF

46. Soft Turbulence in the Atmospheric Boundary Layer

Author

Jánosi, Imre M. and Vattay, Gábor

Subjects
Nonlinear Sciences - Adaptation and Self-Organizing Systems
Abstract

In this work we compare the spectral properties of the daily medium temperature fluctuations with the experimental results of the Chicago Group, in which the local temperature fluctuations were measured in a helium cell. The results suggest that the dynamics of the daily temperature fluctuations is determined by the oft turbulent state of the atmospheric boundary layer, which state is significantly different from low dimensional chaos., Comment: 4 pages, latex, revtex, Ask for figures from vattay@nbivax.nbi.dk

Published
1993
Full Text
View/download PDF

48. Attractiveness of thermally different, uniformly black targets to horseflies: Tabanus tergestinus prefers sunlit warm shiny dark targets

Author

Gábor Horváth, Ádám Pereszlényi, Tímea Tóth, Szabolcs Polgár, and Imre M. Jánosi

Subjects
horsefly, host choice, blood-seeking, thermoreception, polarization vision, parasite–host interaction, Science
Abstract

From a large distance tabanid flies may find their host animal by means of its shape, size, motion, odour, radiance and degree of polarization of host-reflected light. After alighting on the host, tabanids may use their mechano-, thermo-, hygro- and chemoreceptors to sense the substrate characteristics. Female tabanids prefer to attack sunlit against shady dark host animals, or dark against bright hosts for a blood meal, the exact reasons for which are unknown. Since sunlit darker surfaces are warmer than shady ones or sunlit/shady brighter surfaces, the differences in surface temperatures of dark and bright as well as sunlit and shady hosts may partly explain their different attractiveness to tabanids. We tested this observed warmth preference in field experiments, where we compared the attractiveness to tabanids (Tabanus tergestinus) of a warm and a cold shiny black barrel imitating dark hosts with the same optical characteristics. Using imaging polarimetry, thermography and Schlieren imaging, we measured the optical and thermal characteristics of both barrels and their small-scale models. We recorded the number of landings on these targets and measured the time periods spent on them. Our study revealed that T. tergestinus tabanid flies prefer sunlit warm shiny black targets against sunlit or shady cold ones with the same optical characteristics. These results support our new hypothesis that a blood-seeking female tabanid prefers elevated temperatures, partly because her wing muscles are more rapid and her nervous system functions better (due to faster conduction velocities and synaptic transmission of signals) in a warmer microclimate, and thus, she can avoid the parasite-repelling reactions of host animals by a prompt take-off.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results