1. Treatment of Granulomatous Amoebic Encephalitis with Voriconazole and Miltefosine in an Immunocompetent Soldier
- Author
-
Juan M. Bilbao, Imram Umar, Yvonne Qvarnstrom, Marie-Christine Guiot, Govinda S. Visvesvara, Duncan Webster, George Kolyvas, and Kevin Duplisea
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Phosphorylcholine ,Acanthamoeba ,Serology ,Virology ,parasitic diseases ,medicine ,Animals ,Humans ,Granulomatous amoebic encephalitis ,Voriconazole ,Miltefosine ,Granuloma ,biology ,business.industry ,Articles ,Amebiasis ,Triazoles ,medicine.disease ,Debulking ,biology.organism_classification ,Infectious Diseases ,Military Personnel ,Pyrimidines ,Treatment Outcome ,Encephalitis ,Parasitology ,business ,Immunocompetence ,medicine.drug - Abstract
A 38-year-old male immunocompetent soldier developed generalized seizures. He underwent surgical debulking and a progressive demyelinating pseudotumor was identified. Serology and molecular testing confirmed a diagnosis of granulomatous amoebic encephalitis caused by Acanthamoeba sp. in this immunocompetent male. The patient was treated with oral voriconazole and miltefosine with Acanthamoeba titers returning to control levels and serial imaging demonstrating resolution of the residual lesion.
- Published
- 2012