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1. The interaction of patients’ physical status and time to endoscopy on mortality risk in patients with upper gastrointestinal bleeding: A national prospective cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Balzano, A, Bazzoli, F, Bennato, R, Bianco, M A, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De Fanis, C, De Filippo, FR, de Franchis, R, Dell‘Era, A, De Nigris, F, De Matthaeis, M, Di Giorgio, P, Di Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana’, B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R, Metrangolo, S, Montalbano, L M, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Bucci, Cristina, Marmo, Clelia, Soncini, Marco, Riccioni, Maria Elena, Laursen, Stig B., Gralnek, Ian M., and Marmo, Riccardo

Published
2024
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2. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Bazzoli, F, Bennato, R, Bianco, MA, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De-Fanis, C, De-Filippo, FR, de-Franchis, R, Dell‘Era, A, De Nigris, F, De-Matthaeis, M, Di-Giorgio, P, Di-Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana', B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R., Metrangolo, S, Montalbano, LM, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Marmo, Riccardo, Soncini, Marco, Bucci, Cristina, and Zullo, Angelo

Published
2021
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3. Derivation and validation of Re.Co.De death score risk in patients with acute nonvariceal upper GI bleeding

Author

Riccardo Marmo, Marco Soncini, Cristina Bucci, Vincenzo Occhipinti, Lucienne Pellegrini, Angelo Zullo, Amitrano L, Andriulli A, Annese V, Baldassarre G, Bargiggia S, Balzano A, Bazzoli F, Bennato R, Bianco M A, Bizzotto A, Boarino V, Bonanomi AG, Borgheresi P, Bresci G, Buffoli F, Buscarini E, Castrignanò G, Cavallaro LG, Cesaro P, Chirico A, Cipolletta F, Cipolletta L, Conigliaro R, Conte D, Costamagna G, D’ Amico G, De Fanis C, De Filippo FR, de Franchis R, Dell‘ Era A, De Nigris F, De Matthaeis M, Di Giorgio P, Di Giulio E, Esposito P, Ferraris L, Filippino A, Franceschi M, Furio L, Germana B, Grassia R, Imperiali G, Lamanda R, Lauri A, Londoni C, Mangiafico S, Manno M, Marmo C, Meroni R, Metrangolo S, Montalbano L. M, Napolitano G, Nucci A, Orsini L, Parente F, Parravicini M, Paterlini A, Pumpo R, Purita L, Repici A, Riccioni ME, Russo A, Segato S, Sorrentino I, Spinzi G, Spotti D, Tortora A, Triossi O, Zagari RM, and Zambelli A

Subjects
Cohort Studies, Area Under Curve, Acute Disease, Gastroenterology, Humans, Radiology, Nuclear Medicine and imaging, Gastrointestinal Hemorrhage, Prognosis, Risk Assessment, Severity of Illness Index
Abstract

Scores in upper GI bleeding (UGIB) are used to stratify death risk and need for hospitalization at admission, but a tool that incorporates dynamic changes during the hospital stay is lacking. We aimed to develop a death risk score that considers changes in clinical status during hospitalization and compare its performance with existing ones.A multicenter cohort study enrolling patients with UGIB in 50 Italian hospitals from January 2014 to December 2015 was conducted. Data were collected and used to develop a risk score using logistic regression analyses. Performance curves (area under the receiver-operating characteristic [AUROC] curves), sensitivities, specificities, positive and negative predictive values, and outcomes classified as low, intermediate, and high death risk were calculated. The score's performance was externally validated and then compared with other scores.We included 1852 patients with nonvariceal UGIB in the development cohort and 912 in the validation cohorts. The new score, which we named the Re.Co.De (rebleeding-comorbidities-deteriorating) score, included 10 variables depicting the changes in clinical conditions while in the hospital. The mortality AUROC curves were .93 (95% confidence interval, .91-.96) in the derivation cohort and .94 (95% confidence interval, .91-.98) in validation cohort. In a comparison of AUROC curves with other scores, the new score showed a significant performance compared with pre- and postendoscopy scores. Patients with low and high scores had 30-day mortality rates of .001% and 48.2%, respectively.The Re.Co.De score has a higher performance for predicting mortality in patients with UGIB compared with other scores, correctly identifying patients at low and high death risk while in the hospital through a dynamic re-evaluation of clinical status.

Published
2021

4. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Marmo, Riccardo, primary, Soncini, Marco, additional, Bucci, Cristina, additional, Zullo, Angelo, additional, Amitrano, L, additional, Anderloni, A, additional, Andriulli, A, additional, Annese, V, additional, Baldassarre, G, additional, Bargiggia, S, additional, Bazzoli, F, additional, Bennato, R, additional, Bianco, MA, additional, Bizzotto, A, additional, Boarino, V, additional, Bonanomi, AG, additional, Borgheresi, P, additional, Bresci, G, additional, Buffoli, F, additional, Buscarini, E, additional, Castrignanò, G, additional, Cavallaro, LG, additional, Cesaro, P, additional, Chirico, A, additional, Cipolletta, F, additional, Cipolletta, L, additional, Conigliaro, R, additional, Conte, D, additional, Costamagna, G, additional, Covello, F, additional, D'Amico, G, additional, De-Fanis, C, additional, De-Filippo, FR, additional, de-Franchis, R, additional, Dell‘Era, A, additional, De Nigris, F, additional, De-Matthaeis, M, additional, Di-Giorgio, P, additional, Di-Giulio, E, additional, Esposito, P, additional, Ferraris, L, additional, Filippino, A, additional, Franceschi, M, additional, Furio, L, additional, Germana', B, additional, Grassia, R, additional, Imperiali, G, additional, Lamanda, R, additional, Lauri, A, additional, Londoni, C, additional, Mangiafico, S, additional, Manno, M, additional, Marmo, C, additional, Merighi, A, additional, Meroni, R., additional, Metrangolo, S, additional, Montalbano, LM, additional, Napolitano, G, additional, Nucci, A, additional, Orsini, L, additional, Parente, F, additional, Parravicini, M, additional, Paterlini, A, additional, Pumpo, R, additional, Purita, L, additional, Repici, A, additional, Riccioni, ME, additional, Russo, A, additional, Segato, S, additional, Sorrentino, I, additional, Spinzi, G, additional, Spotti, D, additional, Tortora, A, additional, Tomba, C, additional, Triossi, O, additional, Zagari, RM, additional, and Zambelli, A, additional

Published
2021
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5. T01.01.7 THE USE OF A SPECIALIZED BLEEDING-MANAGEMENT TEAM HAD NO IMPACT ON MORTALITY FOR ACUTE UPPER GASTROINTESTINAL BLEEDING: AN ITALIAN PROSPECTIVE MULTICENTER COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Marmo, C., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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6. OC.10.1 THE USE OF PRE-ENDOSCOPIC INTRAVENOUS PROTON PUMP INHIBITORS (PPIS) HAD NO IMPACT ON CLINICAL OUTCOMES IN ACUTE UPPER GASTROINTESTINAL BLEEDING: A PROSPECTIVE MULTICENTER ITALIAN COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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7. The PROSit cohort of infliximab biosimilar in IBD: A prolonged follow-up on the effectiveness and safety across Italy

Author

Armuzzi, A. (ORCID:0000-0003-1572-0118), Fiorino, G., Variola, A., Manetti, N., Fries, W., Orlando, A., Maconi, G., Bossa, F., Cappello, M., Biancone, L., Cantoro, L., Costa, F., D'Inca, R., Lionetti, P., Principi, M., Castiglione, F., Annunziata, M. L., Di Sabatino, A., Di Girolamo, M., Terpin, M. M., Cortelezzi, C. C., Saibeni, S., Amato, A., Ardizzone, S., Guidi, L. (ORCID:0000-0003-3320-7094), Danese, S., Massella, A., Ventra, A., Rizzuto, G., Massari, A., Perri, F., Annese, V., Saettone, S., Tari, R., Petruzzellis, C., Meucci, G., Imperiali, G., Guglielmi, F. W., Mazzuoli, S., Caserta, L., Parodi, M. C., Colli, A., Ronchetti, A., Pugliese, D., Geccherle, A., Rogai, F., Milani, S., Renna, S., Cassinotti, A., Andriulli, A., Martino, G., Scrivo, B., Troncone, E., Kohn, A., Bertani, L., Lorenzon, G., Ghione, S., Nardone, O., Vecchi, M., Bertani, A., Bosani, M. A., Bezzio, C., Salerno, R., Armuzzi, A. (ORCID:0000-0003-1572-0118), Fiorino, G., Variola, A., Manetti, N., Fries, W., Orlando, A., Maconi, G., Bossa, F., Cappello, M., Biancone, L., Cantoro, L., Costa, F., D'Inca, R., Lionetti, P., Principi, M., Castiglione, F., Annunziata, M. L., Di Sabatino, A., Di Girolamo, M., Terpin, M. M., Cortelezzi, C. C., Saibeni, S., Amato, A., Ardizzone, S., Guidi, L. (ORCID:0000-0003-3320-7094), Danese, S., Massella, A., Ventra, A., Rizzuto, G., Massari, A., Perri, F., Annese, V., Saettone, S., Tari, R., Petruzzellis, C., Meucci, G., Imperiali, G., Guglielmi, F. W., Mazzuoli, S., Caserta, L., Parodi, M. C., Colli, A., Ronchetti, A., Pugliese, D., Geccherle, A., Rogai, F., Milani, S., Renna, S., Cassinotti, A., Andriulli, A., Martino, G., Scrivo, B., Troncone, E., Kohn, A., Bertani, L., Lorenzon, G., Ghione, S., Nardone, O., Vecchi, M., Bertani, A., Bosani, M. A., Bezzio, C., and Salerno, R.

Abstract

Background: We report a prospective, nationwide cohort evaluating the safety and effectiveness of CT-P13. Methods: A structured database was used to record serious adverse events (SAEs), clinical remission/response, inflammatory biomarkers (CRP and calprotectin), and endoscopic findings. Results: Eight hundred ten patients with inflammatory bowel disease (IBD) (452 Crohn's disease [CD]) were enrolled. Four hundred fifty-nine patients were naïve to anti-TNFα (group A), 196 had a previous exposure (group B), and the remaining 155 were switched to CT-P13 (group C). All patients were included in the safety evaluation with a mean follow-up of 345 ± 215 days and a total number of 6501 infusions. One hundred fifty-four SAEs were reported (19%), leading to cessation of the biosimilar in 103 subjects (12.7%). Infusion reactions were 71, leading to cessation of the biosimilar in 53 subjects (6.5%), being significantly more frequent in patients pre-exposed to anti-TNFα (P = 0.017). The efficacy of therapy was calculated in 754 IBD patients, with a mean follow-up of 329 ± 202 days. Forty-eight patients had a primary failure (6.4%), and 188 (25.6%) lost response during follow-up. Six hundred twenty-eight (364 CD) and 360 IBD patients (222 CD) completed the follow-up at 6 and 12 months, respectively. At 12 months, patients without loss of response were 71%, 64%. and 82% in groups A, B, and C, respectively (log rank P = 0.01). Clinical/endoscopic scores and inflammatory biomarkers dropped significantly in CD and UC patients (P = 0.01 and P < 0.0001) compared with baseline. Conclusions: In this large prospective cohort, no further signals of difference in safety and effectiveness of CT-P13 in IBD has been observed.

Published
2019

8. OC.11.5 TRIGGER AND TARGET TRANSFUSION STRATEGY IN PATIENTS WITH NON-VARICEAL ACUTE UPPER GASTROINTESTINAL BLEEDING (NV-AUGIB): A PROSPECTIVE MULTICENTRE OBSERVATIONAL STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Spada, C., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2019
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12. OC.14.2 PREDICTIVE FACTORS OF MORTALITY IN ACUTE GASTROINTESTINAL BLEEDING IN ITALY (AUGIB): A NEW PRE-ENDOSCOPY PROGNOSTIC MODEL FROM A MULTICENTER STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Eera, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2018
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14. P.10.8: Mortality from Acute Upper Gastrointestinal Bleeding (UGIB): The Role of the Organizational and Health Care Course: A Prospective Multicentre Observational Study in Italy

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, F., additional, Orsini, L., additional, Bennato, R., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Zingone, F., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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15. P.10.1: Transfusion Strategy and Death Risk in Patients with Acute Non-Variceal Upper Gastro Intestinal Bleeding (NV-UGIB) in Italy: A Prospective Multicenter Observational Study

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Mastrangelo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Zingone, F., additional, Lamanda, R., additional, Lauri, R., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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16. P.10.3: Mortality in Upper Gastrointestinal Bleeding in Italy: Data from National Survey

Author

Soncini, M., primary, Marmo, R., additional, Conte, D., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Tomba, C., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, and Balzano, A., additional

Published
2017
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17. P.12.3: Accuracy of Endoscopic Resection for Non-Pedunculated Colonic Lesions 5–20 Mm with or without Narrow Band Imaging (NBI): A Multicentre, Prospective, Randomized Trial

Author

Andrealli, A., primary, Amato, A., additional, Imperiali, G., additional, Lenoci, N., additional, Mandelli, G., additional, Paggi, S., additional, Radaelli, F., additional, Rondonotti, E., additional, Terreni, N., additional, Cavallaro, F., additional, Masci, E., additional, and Spinzi, G., additional

Published
2017
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18. P.10.10: Mortality Causes from Acute Upper Gastrointestinal Bleeding: A Prospective Multicentre Observational Study

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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19. P.10.9: Outpatient Management of Patients with Glasgow-Blatchford Bleeding Score Low-Risk Upper-Gastrointestinal Hemorrhage: A Multicenter Validation Study in Italy

Author

Marmo, R., primary, Soncini, M., additional, Orsini, L., additional, Cipolletta, F., additional, Bennato, R., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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20. P.15.8 POOR OUTCOME FROM ACUTE UPPER GASTROINTESTINAL BLEEDING IN PATIENTS WITH LIVER CIRRHOSIS: A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, L., additional, Parente, F., additional, Paterlini, A., additional, Orsini, L., additional, Guardascione, M., additional, Amitrano, L., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Dell'Era, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Spinzi, G., additional, Imperiali, G., additional, Maringhi, A., additional, Boarino, V., additional, Bresci, G., additional, Metrangolo, S., additional, Bucci, C., additional, Baldassarre, G., additional, Gasparini, P., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Masci, E., additional, Marin, R., additional, Antoniazzi, S., additional, Ferraris, L., additional, Repici, A., additional, Andreloni, A., additional, Bianco, M.A., additional, Rotondano, G., additional, De Matthaeis, M., additional, Lauri, A., additional, De Fanis, C., additional, Borgheresi, P., additional, De Stefano, S., additional, Lamanda, R., additional, Furio, L., additional, Russo, A., additional, Maringhini, A., additional, Politi, F., additional, Di Giorgio, P., additional, Pumpo, R., additional, Martorano, M., additional, Triossi, O., additional, Coccia, G., additional, Montalbano, L.M., additional, Zagari, R.M., additional, Balzano, A., additional, Buscarini, E., additional, Conte, D., additional, D'Amico, G., additional, Di Giulio, E., additional, and De Franchis, R., additional

Published
2016
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21. P.15.9 TRANSFUSION STRATEGY AND DEATH RISK IN PATIENTS WITH ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING (NV-UGIB) IN ITALY: A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, L., additional, Parente, F., additional, Paterlini, A., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Dell'Era, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Spinzi, G., additional, Imperiali, G., additional, Maringhi, A., additional, Boarino, V., additional, Bresci, G., additional, Metrangolo, S., additional, Bucci, C., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Masci, E., additional, Marin, R., additional, Antoniazzi, S., additional, Ferraris, L., additional, Repici, A., additional, Andreloni, A., additional, Bianco, M.A., additional, Rotondano, G., additional, De Matthaeis, M., additional, Lauri, A., additional, De Fanis, C., additional, Borgheresi, P., additional, De Stefano, S., additional, Lamanda, R., additional, Furio, L., additional, Russo, A., additional, Di Giorgio, P., additional, Politi, F., additional, Pumpo, R., additional, Triossi, O., additional, Coccia, G., additional, Montalbano, L.M., additional, Zagari, R.M., additional, Balzano, A., additional, Buscarini, E., additional, Conte, D., additional, D'Amico, G., additional, Di Giulio, E., additional, Gasparini, P., additional, and De Franchis, R., additional

Published
2016
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22. P.15.3 INCREASED PERFORMANCE OF AN UPDATED ROCKALL SCORE IN ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING: A PROSPECTIVE MULTICENTRE ITALIAN STUDY

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, L., additional, Parente, F., additional, Paterlini, A., additional, Bennato, R., additional, Cipolletta, F., additional, Amitrano, L., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Dell'Era, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Spinzi, G., additional, Imperiali, G., additional, Merighi, A., additional, Boarino, V., additional, Bresci, G., additional, Metrangolo, S., additional, Bucci, C., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Masci, E., additional, Marin, R., additional, Antoniazzi, S., additional, Ferraris, L., additional, Repici, A., additional, Andreloni, A., additional, Bianco, M.A., additional, De Matthaeis, M., additional, Lauri, A., additional, De Fanis, C., additional, Borgheresi, P., additional, De Stefano, S., additional, Lamanda, R., additional, Furio, L., additional, Russo, A., additional, Maringhini, A., additional, Politi, F., additional, Di Giorgio, P., additional, Pumpo, R., additional, Martorano, M., additional, Triossi, O., additional, Coccia, G., additional, Montalbano, L.M., additional, Zagari, R.M., additional, Buscarini, E., additional, Conte, D., additional, D'Amico, G., additional, Di Giulio, E., additional, Balzano, A., additional, Gasparini, P., additional, Rotondano, G., additional, and De Franchis, R., additional

Published
2016
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24. Predicting mortality in non-variceal upper gastrointestinal bleeders: validation of the Italian PNED Score and Prospective Comparison with the Rockall Score

Author

Marmo, R, Koch, M, Cipolletta, L, Capurso, L, Grossi, E, Cestari, Renzo, Bianco, Ma, Pandolfo, N, Dezi, A, Casetti, T, Lorenzini, I, Germani, U, Imperiali, G, Stroppa, I, Barberani, F, Boschetto, S, Gigliozzi, A, Gatto, G, Peri, V, Buzzi, A, Della Casa, D, Di Cicco, M, Proietti, M, Aragona, G, Giangregorio, F, Allegretta, L, Tronci, S, Michetti, P, Romagnoli, P, Piubello, W, Ferri, B, Fornari, F, Del Piano, M, Pagliarulo, M, Di Mitri, R, Trallori, G, Bagnoli, S, Frosini, G, Macchiarelli, R, Sorrentini, I, Pietrini, L, De Stefano, S, Ceglia, T, Chiozzini, G, Salvagnini, M, Di Muzio, D, Rotondano, G, and Italian registry on upper gastrointestinal bleeding

Subjects
Male, medicine.medical_specialty, Validation study, Upper Gastrointestinal Tract, Internal medicine, Epidemiology, 80 and over, medicine, Upper gastrointestinal, Humans, Aged, Aged, 80 and over, Settore MED/12 - Gastroenterologia, Prognosis, Gastrointestinal Hemorrhage, Middle Aged, Female, Hepatology, business.industry, Gastroenterology, Surgery, Multicenter study, Varices, business, Rockall score, Venous disease
Abstract

We sought (i) to validate a new prediction rule of mortality (Progetto Nazionale Emorragia Digestiva (PNED) score) on an independent population with non-variceal upper gastrointestinal bleeding (UGIB) and (ii) to compare the accuracy of the Italian PNED score vs. the Rockall score in predicting the risk of death.We conducted prospective validation of analysis of consecutive patients with UGIB at 21 hospitals from 2007 to 2008. Outcome measure was 30-day mortality. All the variables used to calculate the Rockall score as well as those identified in the Italian predictive model were considered. Calibration of the model was tested using the chi2 goodness-of-fit and performance characteristics with receiver operating characteristic (ROC) analysis. The area under the ROC curve (AUC) was used to quantify the diagnostic accuracy of the two predictive models.Over a 16-month period, data on 1,360 patients were entered in a national database and analyzed. Peptic ulcer bleeding was recorded in 60.7% of cases. One or more comorbidities were present in 66% of patients. Endoscopic treatment was delivered in all high-risk patients followed by high-dose intravenous proton pump inhibitor in 95% of them. Sixty-six patients died (mortality 4.85%; 3.54-5.75). The PNED score showed a high discriminant capability and was significantly superior to the Rockall score in predicting the risk of death (AUC 0.81 (0.72-0.90) vs. 0.66 (0.60-0.72), P0.000). Positive likelihood ratio for mortality in patients with a PNED risk score8 was 16.05.The Italian 10-point score for the prediction of death was successfully validated in this independent population of patients with non-variceal gastrointestinal bleeding. The PNED score is accurate and superior to the Rockall score. Further external validation at the international level is needed.

Published
2010

26. Tumour necrosis factor alpha in segmental colitis associated with diverticula

Author

Ierardi, E, Meucci, G, Hassan, Cesare, Zullo, A, Imperiali, G, De Francesco, V, Panella, C, Morini, S, Minoli, G., Ierardi, E, Meucci, G, Hassan, Cesare, Zullo, A, Imperiali, G, De Francesco, V, Panella, C, Morini, S, and Minoli, G.

Abstract

The pathogenesis of segmental colitis associated with diverticula (SCAD) is unclear, but tumour necrosis factor alpha (TNF-alpha) has been shown to play a pivotal role in the pathogenesis of inflammatory bowel diseases. The aim of this study was to assess TNF-alpha levels in patients with SCAD. In a post hoc analysis of a prospective multicenter study, tissue samples from 13 patients diagnosed with SCAD were subjected to histological analyses. The severity of the inflammation was assessed by means of a histological score and histomorphometry (number of inflammatory cells/mm2). Immunohistochemical staining with an antibody against TNF-alpha was performed on all biopsies and the degree of staining expressed as the percentage of positive stromal cells/1000 counted (TNF-alpha score). Matched patients with irritable bowel syndrome (IBS) were used as controls. Over-expression of TNF-alpha was found in all SCAD patients (38.6 +/- 10.4%), and it was associated with a high histological score (2.5 +/- 0.5) and neutrophil cell count (16.3 +/- 3/mm2). These values were distinctly higher than those found in the IBS controls. Our data suggest that TNF-alpha activity is involved in SCAD pathogenesis, similarly to what occurs in Crohn's disease and ulcerative colitis.

Published
2008

27. P.07.3 PILLCAM COLON CAPSULE 2® IN THE SETTING OF COLORECTAL CANCER SCREENING PROGRAM: PRELIMINARY RESULTS OF THE COMPARISON WITH A NEW INTEGRATED REFERENCE STANDARD

Author

Rondonotti, E., primary, Mandelli, G., additional, Borghi, C., additional, Paggi, S., additional, Radaelli, F., additional, Terruzzi, V., additional, Imperiali, G., additional, Terreni, N., additional, Lenoci, N., additional, Amato, A., additional, Martegani, A., additional, and Spinzi, G., additional

Published
2013
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30. P.06.10 QUALITY OF CARE IN INFLAMMATORY BOWEL DISEASE IN ITALY ACCORDING TO PHYSICIANS' PERCEPTIONS: INITIAL RESULTS FROM SOLUTION TRIAL (AN ONGOING PROSPECTIVE IG-IBD STUDY)

Author

Bortoli, A., primary, Spina, L., additional, Milla, M., additional, Grasso, G., additional, Ferraris, L., additional, Savarino, V., additional, Riegler, G., additional, Cucino, C., additional, Di Leo, V., additional, Marconi, S., additional, Imperiali, G., additional, Lorenzini, I., additional, Snider, L., additional, and Prada, A., additional

Published
2012
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31. First bleeding episode from oesophageal varices in cirrhotic patients: a prospective study of endoscopic predictive factors

Author

Colombo E, Ma, Casiraghi, Minoli G, Prada A, Vittorio Terruzzi, Bortoli A, Carnovali M, Gullotta R, Imperiali G, and Comin U

Subjects
Adult, Aged, 80 and over, Liver Cirrhosis, Male, Analysis of Variance, Chi-Square Distribution, Middle Aged, Esophageal and Gastric Varices, Prognosis, Italy, Predictive Value of Tests, Humans, Female, Esophagoscopy, Prospective Studies, Gastrointestinal Hemorrhage, Aged, Follow-Up Studies
Abstract

Two hundred patients affected by liver cirrhosis and oesophageal varices were studied in 9 Gastrointestinal Units in Lombardy (Northern Italy) in order to assess factors possibly related to variceal bleeding. Only patients without any previous episode of gastrointestinal bleeding were included in the prospective evaluation. For each patient demographic data, aetiology of cirrhosis, various clinical and biochemical parameters able to group patients into the three Child-Pugh Classes, endoscopic items for calculation of Beppu's and of NIEC prognostic scores were recorded on computerized cards. Patients were regularly interviewed every three months for one year and underwent an upper gastrointestinal endoscopy at enrollment, after six months and in case of bleeding. Within the twelve-month follow-up period, 29 out of the 200 patients (14%) bled and 52 out of 200 died (26%). In 16 of the 52 patients who died (59% of bleeding patients) death was directly related to gastrointestinal bleeding. Bleeding from oesophageal varices was endoscopically proven in 19/29 patients, in another 9 bleeding was classified as from unknown source and in one patient a bleeding gastric ulcer was diagnosed. Univariate analysis of all the recorded clinical, biochemical and endoscopic parameters, performed by Chi-square method and Fisher exact test showed that the presence of RWM (p0.001) was the only factor significantly associated to variceal bleeding within one year. Relationship between size of varices and bleeding was very close to the statistical significance but did not achieve it (p = 0.058).

Published
1995

36. PREDICTIVE FACTORS OF MORTALITY IN UPPER NONVARICEAL GI BLEEDING: VALIDATION OF A NEW PROGNOSTIC MODEL FROM A MULTICENTER ITALIAN STUDY

Author

Marmo, R., primary, Rotondano, G., additional, Koch, M., additional, Cipolletta, L., additional, Capurso, L., additional, Trallori, G., additional, Cestari, R., additional, Frosini, G., additional, Imperiali, G., additional, Casetti, T., additional, Boschetto, S., additional, DiMitri, S., additional, Stroppa, I., additional, DelPiano, M., additional, Salvagnini, M., additional, Gatto, G., additional, Sorrentini, I., additional, DeStefano, S., additional, Di Cicco, M., additional, Michetti, P., additional, Lorenzini, I., additional, Fornari, F., additional, Piubello, W., additional, Dezi, A., additional, Milla, M., additional, Bianco, M.A., additional, Della Casa, N., additional, Longobardi, G., additional, Triossi, O., additional, Gigliozzi, A., additional, Carmagnola, S., additional, DiMuzio, D., additional, Marino, M., additional, Russo, F., additional, Lamanda, R., additional, Proietti, M., additional, Allegretti, A., additional, Germani, U., additional, Giangregorio, F., additional, Zagni, I., additional, and Grossi, E., additional

Published
2009
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37. PREDICTION OF MORTALITY FROM UPPER GASTRO-INTESTINAL BLEEDING: COMPARISON OF ROCKALL SCORE VS THE ITALIAN PNED SCORE

Author

Marmo, R., primary, Rotondano, G., additional, Koch, M., additional, Cipolletta, L., additional, Capurso, L., additional, Trallori, G., additional, Cestari, R., additional, Frosini, G., additional, Imperiali, G., additional, Casetti, T., additional, Boschetto, S., additional, Di Mitri, R., additional, Stroppa, I., additional, Del Piano, M., additional, Salvagnini, M., additional, Gatto, G., additional, Sorrentini, I., additional, De Stefano, S., additional, Di Cicco, M., additional, Michetti, P., additional, Lorenzini, I., additional, Fornari, F., additional, Piubello, W., additional, Dezi, A., additional, Bagnoli, S., additional, Bianco, M.A., additional, Della Casa, N., additional, Macchiarelli, R., additional, Buzzi, A., additional, Gigliozzi, A., additional, Pagliarulo, M., additional, Di Muzio, D., additional, Peri, V., additional, Pietrini, L., additional, Ceglia, T., additional, Proietti, M., additional, Romagnoli, P., additional, Germani, U., additional, Aragona, G., additional, Ferri, B., additional, and Grossi, E., additional

Published
2009
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38. PA.218 DIFFERENT ENDOTHERAPY PROCEDURES HAD DIFFERENT IMPACT ON REBLEEDING AND DEATH RATE FROM ULCER BLEEDING WITH HIGH RISK STIGMATA: A POST HOC ANALYSIS FROM A RANDOMIZED CLINICAL TRIAL

Author

Marmo, R., primary, Loperfido, S., additional, Focareta, R., additional, Leo, P., additional, Fornari, F., additional, Garripoli, A., additional, Tonti, P., additional, Peyre, S., additional, Spadaccini, A., additional, Merla, A., additional, Caroli, A., additional, Forte, G., additional, Aragona, G., additional, Imperiali, G., additional, Forte, F., additional, Monica, F., additional, Caruso, N., additional, Giusi, F., additional, and Andriulli, A., additional

Published
2008
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39. Factor Associated with Mortality from Non Variceal Upper Gastrointestinal Bleeding (UGIB) in Italy: A Nationwide Prospective Study

Author

Marmo, Riccardo, primary, Koch, M., additional, Cipolletta, L., additional, Capurso, L., additional, Rotondano, G., additional, Bianco, Maria Antonietta, additional, Dezi, A., additional, Pastorelli, A., additional, Torre, E. Sanz, additional, Lorenzini, I., additional, Girardi, L., additional, Romagnoli, P., additional, Casa, D. Della, additional, Buzzi, A., additional, Fasoli, R., additional, Brunati, S., additional, Germani, U., additional, Di Matteo, G., additional, Giorgio, P., additional, Imperiali, G., additional, Minoli, G., additional, Barberani, F., additional, Boschetto, S., additional, Gatto, G., additional, and Amuso, M., additional

Published
2007
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45. Acute self-limiting jejunitis as the first manifestation of microscopic polyangiitis associated with Sjogren's disease: report of one case and review of the literature.

Author

Radaelli, Franco, Meucci, Gianmichele, Spinzi, Giancarlo, Terruzzi, Vittorio, Imperiali, Gianni, Lenoci, Nicoletta, Strocchi, Enrico, Sangiovanni, Angelo, Terreni, Natalia, Quarenghi, Marida, Minoli, Giorgio, Radaelli, F, Meucci, G, Spinzi, G, Terruzzi, V, Imperiali, G, Lenoci, N, Strocchi, E, Sangiovanni, A, and Terreni, N

Published
1999
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46. Single bolus of midazolam versus bolus midazolam plus meperidine for colonoscopy: A prospective, randomized, double-blind trial

Author

Radaelli, F., Meucci, G., Terruzzi, V., Spinzi, G., Imperiali, G., Strocchi, E., Lenoci, N., Terreni, N., Mandelli, G., and Minoli, G.

Abstract

Background: The aim of this study was to determine whether a single bolus of meperidine in addition to midazolam improves patient tolerance during colonoscopy. Methods: Consecutive patients undergoing outpatient colonoscopy were randomly assigned in double-blind fashion to receive a single rapid intravenous bolus of 5 mg of midazolam and placebo (Group A, n = 125) or 5 mg midazolam plus 50 mg meperidine (Group B, n = 128). Tolerance (4-point scale: 1 excellent, 4 unbearable), pain (4-point scale: 1 none, 4 severe) and willingness to undergo another colonoscopy were assessed 24 to 48 hours later in a telephone interview conducted by an independent observer blinded to the regimen of sedative medication. Results: Significantly more patients in Group A reported moderate or severe pain (28% vs. 9%; p < 0.001), poor or unbearable tolerance (18% vs. 6%; p < 0.01) and unwillingness to undergo colonoscopy again in the future (14% vs. 5%; p < 0.05). By multivariate analysis, randomization to the midazolam group and younger age were the only variables independently associated with the risk of reporting at least one of these outcomes. Recovery time, frequency of oxygen desaturation, and need for supplemental oxygen were not significantly different between the 2 groups. Conclusions: The addition of a single bolus of meperidine to midazolam improves patient tolerance and lessens pain during colonoscopy without significantly increasing the frequency of side effects or prolonging recovery time. (Gastrointest Endosc 2003;57:329-35.)

Published
2003
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50. Pseudoxanthoma elasticum: A rare cause of gastrointestinal bleeding

Author

Spinzi G, Strocchi E, Imperiali G, Sangiovanni A, Vittorio Terruzzi, and Minoli G

Subjects
Adult, Male, Adolescent, Biopsy, Gastroscopy, Stomach, Humans, Female, Pseudoxanthoma Elasticum, Gastrointestinal Hemorrhage, Skin
Abstract

Pseudoxanthoma elasticum (PXE) is a rare connective tissue disorder. The main clinical features of this condition are characteristic skin lesions, angioid streaks of the fundus oculi, and occlusive vascular disease. Gastric hemorrhage is a rare complication. A gastroscopic examination was performed on two patients with PXE who presented with upper gastrointestinal tract bleeding. The two patients had submucosal yellowish nodular lesions similar to the xanthoma-like skin lesions seen in the disease. We suggest that a diagnosis of PXE be considered for any patient with gastrointestinal hemorrhage, especially if routine clinical and endoscopic examination fail to reveal the cause, and if raised yellow plaque-like lesions are seen in the stomach by endoscopy.

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