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4,344 results on '"Imperato A"'

2. COPD Exacerbations Before and During COVID-19 in France, Germany, Italy, the UK and the US

Author

Martinez FJ, Papi A, Welte T, Singh D, Galkin DV, Guasconi A, Pirondi S, Georges G, Imperato J, and Hermans R

Subjects
copd exacerbation, chronic obstructive pulmonary disease, covid-19, electronic health records, real-world study, Diseases of the respiratory system, RC705-779
Abstract

Fernando J Martinez,1 Alberto Papi,2 Tobias Welte3,4 ,† Dave Singh,5 Dmitry V Galkin,6 Alessandro Guasconi,7 Stefania Pirondi,7 George Georges,7 Joseph Imperato,8 Ruben Hermans9 1Weill Cornell Medicine, New York–Presbyterian Hospital, New York, NY, USA; 2Research Center on Asthma and COPD, Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 3Pneumonology and Infectiology, Member of the German Center of Lung Research, Hannover Medical School, Hannover, Germany; 4Biomedical Research in End Stage and Obstructive Lung Disease, German Center for Lung Research, Hannover Medical School, Hannover, Germany; 5Medicines Evaluations Unit, University of Manchester, Manchester University Foundation Hospitals Trust, Manchester, UK; 6Global Clinical Development, Chiesi USA, Cary, NC, USA; 7Global Clinical Development, Chiesi Farmaceutici, S.p.A, Parma, Italy; 8Medical Affairs, IQVIA Inc, New York, NY, USA; 9Medical Affairs, IQVIA Inc, London, UK†Prof. Tobias We 50% in 2020 compared with 2019. The proportions of patients with an exacerbation increased in most countries in 2021. Across each country, seasonal exacerbation increases seen during autumn and winter in pre-pandemic years were absent during the first year of the pandemic. The percentage of patients filling COPD prescriptions across each country increased by 4.53– 22.13% in 2019 to 9.94– 34.17% in 2021.Conclusion: Early, steep declines in exacerbation rates occurred in 2020 versus 2019 across all five countries and were accompanied by a loss of the seasonal pattern of exacerbation.Keywords: COPD exacerbation, chronic obstructive pulmonary disease, COVID-19, electronic health records, real-world study

Published
2024

3. A Black Hole Kicked At Birth: MAXI J1305-704

Author

Kimball, Chase, Imperato, Sam, Kalogera, Vicky, Rocha, Kyle A., Doctor, Zoheyr, Andrews, Jeff J., Dotter, Aaron, Zapartas, Emmanouil, Bavera, Simone S., Kovlakas, Konstantinos, Fragos, Tassos, Srivastava, Phillip M., Misra, Devina, Sun, Meng, and Xing, Zepei

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

When a compact object is formed in a binary, any mass lost during core collapse will impart a kick on the binary's center of mass. Asymmetries in this mass loss or neutrino emission would impart an additional natal kick on the remnant black hole or neutron star, whether it was formed in a binary or in isolation. While it is well established that neutron stars receive natal kicks upon formation, it is unclear whether black holes do as well. Here, we consider the low-mass X-ray binary MAXI J1305-704, which has been reported to have a space velocity $\gtrsim$ 200 km/s. In addition to integrating its trajectory to infer its velocity upon formation of its black hole, we account for recent estimates of its period, black hole mass, mass ratio, and donor effective temperature from photometric and spectroscopic observations. We find that if MAXI J1305-704 formed via isolated binary evolution in the thick Galactic disk, then the supernova that formed its black hole imparted a natal kick of at least 70 km/s while ejecting less than $\simeq 1$ M$_\odot$ with 95% confidence assuming uninformative priors on mass loss and natal kick velocity., Comment: Accepted Astrophysical Journal Letters; 9 pages, 5 figures

Published
2022
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5. Single-shot quantitative aberration and scattering length measurements in mouse brain tissues using an extended-source Shack-Hartmann wavefront sensor

Author

Imperato, Sophia, Harms, Fabrice, Hubert, Antoine, Mercier, Mathias, Bourdieu, Laurent, and Fragola, Alexandra

Subjects
Physics - Optics, Physics - Biological Physics
Abstract

Deep fluorescence imaging in mammalian brain tissues remains challenging due to scattering and optical aberration-induced loss in signal and resolution. Correction of aberrations using adaptive optics (AO) requires their reliable measurement in the tissues. Here, we show that an extended-source Shack-Hartmann wavefront sensor (ESSH) allows quantitative aberration measurements through fixed brain slices with a thickness up to four times their scattering length. We demonstrate in particular that this wavefront measurement method based on image correlation is more robust to scattering compared to the standard centroid-based approach. Finally, we obtain a measurement of the tissue scattering length taking advantage of the geometry of a Shack-Hartmann sensor.

Published
2022
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8. Quantification of Airborne Particulate Matter and Trace Element Deposition on Hedera helix and Senecio cineraria Leaves

Author

Anabel Saran, Mariano Javier Mendez, Diego Gabriel Much, Valeria Imperato, Sofie Thijs, Jaco Vangronsveld, and Luciano Jose Merini

Subjects
particulate matter, air pollution, trace elements, bio-monitors, plants, Botany, QK1-989
Abstract

In both developed and developing countries, atmospheric pollution with particulate matter (PM) remains an important issue. Despite the health effects of poor air quality, studies on air pollution are often limited by the high costs of continuous monitoring and the need for extensive sampling. Furthermore, these particles are often enriched with potentially toxic trace elements and organic pollutants. This study evaluates both the composition of atmospheric dust accumulated during a certain timespan on Hedera helix and Senecio cineraria leaves and the potential for their use as bio-monitors. The test plants were positioned near automatic air quality monitoring stations at four different sites with respectively high, moderate and low traffic intensity. The gravimetric deposition of PM10 and PM2.5 on leaves was compared with data recorded by the monitoring stations and related to the weather conditions reported by Argentina’s National Meteorological Service. To determine the presence of trace elements enriching the PM deposited on leaves, two analytical techniques were applied: XRF (not destructive) and ICP (destructive). The results indicated that only in the unpaved street location (site 2) did PM10 and PM2.5 concentrations (90 µg m−3 and 9 µg m−3) in the air exceed more than five times WHO guidelines (15 µg m−3 and 5 µg m−3). However, several trace elements were found to be enriching PM deposited on leaves from all sites. Predominantly, increased concentrations of Cd, Cu, Ti, Mn, Zn and Fe were found, which were associated with construction, traffic and unpaved street sources. Furthermore, based on its capability to sequester above 2800 µg cm−2 of PM10, 2450 µg cm−2 of PM2.5 and trace elements, Senecio cineraria can be taken into consideration for adoption as a bio-monitor or even for PM mitigation.

Published
2024
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11. Health-Care Resource Utilization and Treatment Patterns in Men with Erectile Dysfunction and Benign Prostatic Hyperplasia-Associated Lower Urinary Tract Symptoms in the United States: A Retrospective Database Study

Author

Goldstein I, Hassan T, Zou K, Divino V, DeKoven M, Imperato J, Anupindi VR, and Li J

Subjects
medication adherence, persistence, phosphodiesterase-5 inhibitor, real world evidence, tadalafil, Medicine (General), R5-920
Abstract

Irwin Goldstein,1 Tarek Hassan,2 Kelly Zou,3 Victoria Divino,4 Mitch DeKoven,4 Joseph Imperato,3 Vamshi Ruthwik Anupindi,4 Jim Li3 1Department of Sexual Medicine, Alvarado Hospital, San Diego, CA, USA; 2Department of Urology, Viatris Inc, Canonsburg, PA, USA; 3Global Medical Analytics and Real World Evidence, Viatris Inc, Canonsburg, PA, USA; 4Health Economics/Outcomes Research and Real-World Insights, IQVIA, Falls Church, VA, USACorrespondence: Tarek Hassan, Global Medical Lead, Department of Urology, Global Medical and Clinical, Viatris Inc, 1000 Mylan Blvd, Canonsburg, PA, 15317, USA, Tel +1 3474432850, Email tarek.hassan@viatris.comObjective: To compare health-care resource utilization (HCRU) outcomes in patients with erectile dysfunction (ED) and benign prostatic hyperplasia-associated lower urinary tract symptoms (BPH-LUTS) treated with tadalafil or non-phosphodiesterase-5 inhibitor (PDE5i), adherence to and persistence with tadalafil by dose in the United States (US).Methods: This was a noninterventional, real-world evidence study of men (aged ≥ 45 years) with ED and BPH-LUTS treated with tadalafil or non-PDE5i. The IQVIA US PharMetrics Plus claims database was used. Outcomes included all-cause and disease-specific HCRU over a 12-month follow-up. Persistence with and adherence to tadalafil were evaluated stratified by dose (10 or 20 mg as needed; 2.5 or 5 mg as once daily [OD]).Results: The final sample comprised 11,351 tadalafil and 48,722 non-PDE5i patients. For all-cause and disease-specific HCRU, including prescription fills, physician office visits, emergency room visits, laboratory tests, radiology examinations, outpatient surgical services, ancillary services, hospitalizations, mean number of utilizations, and proportions of patients with one or more utilizations, were lower for tadalafil compared with non-PDE5i patients. For all-cause HCRU, proportions of patients with one or more emergency room visits (18.6% vs 21.7%, p< 0.0001) and outpatient surgical visits (63.0% vs 68.8%, p< 0.0001) were significantly lower for tadalafil compared with non-PDE5i patients. For disease-specific HCRU, the proportion with one or more disease-specific physician office visits (55.1% vs 91.4%), laboratory tests (34.8% vs 58.2%), outpatient surgery (24.3% vs 38.9%), or outpatient ancillary services (18.0% vs 29.8%) were significantly lower for tadalafil compared with non-PDE5i patients (all comparisons, p< 0.0001). Mean persistence days (179.8 vs 61.2), proportion persistence (35.8% vs 6.5%), and mean adherence (0.5 vs 0.2) were higher for tadalafil OD doses than as-needed tadalafil doses.Conclusion: Patients on tadalafil demonstrated less HCRU and higher persistence and adherence (OD versus as-needed tadalafil) than non-PDE5i patients, which demonstrates its benefit in the management of ED and BPH-LUTS in the US.Plain Language Summary: Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) conditions are more common in adult men and increase with age. These conditions affect their sexual satisfaction, create mental stress, and impact their interactions with family and associates. This study examined the patterns of health-care resource utilization (HCRU) in 11,351 patients treated with tadalafil versus 48,722 not treated with any PDE5i and compared treatment adherence to and persistence with tadalafil in patients with ED and comorbid BPH-LUTS in the US. All-cause and disease-specific HCRU were lower in patients treated with tadalafil than patients not treated with any PDE5i. The persistence with and adherence to therapy was higher with once-daily dose of tadalafil (2.5 or 5 mg) compared with as-needed dose of tadalafil (10 or 20 mg). Therefore, a lower dose of tadalafil demonstrated benefit in the management of men with ED and BPH-LUTS.Keywords: medication adherence, persistence, phosphodiesterase-5 inhibitor, real-world evidence, tadalafil

Published
2023

19. Tumors of Choroid Plexus and Other Ventricular Tumors

Author

Spennato, Pietro, De Martino, Lucia, Russo, Carmela, Errico, Maria Elena, Imperato, Alessia, Mazio, Federica, Miccoli, Giovanni, Quaglietta, Lucia, Abate, Massimo, Covelli, Eugenio, Donofrio, Vittoria, Cinalli, Giuseppe, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Hanaei, Sara, editor

Published
2023
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21. A retrospective case study of successful translational research: Cardiovascular disease risk assessment, experiences in community engagement

Author

Michael E. Bales, Jifeng Zhu, Christine A. Ganzer, Farid Aboharb, Allegra Keeler, Krista A. Ryon, Brett J. Ehrmann, Julianne Imperato-McGinley, and for the H2H Consortium

Subjects
Community health partnerships, health disparities, cardiovascular diseases, diabetes, Medicine
Abstract

In underserved communities across New York City, uninsured adults encounter a greater risk of cardiovascular disease (CVD) and diabetes. The Heart-to-Heart Community Outreach Program (H2H) addresses these disparities by screening for CVD risk factors, identifying healthcare access barriers, and fostering community engagement in translational research at the Weill Cornell Medicine Clinical and Translational Science Award (CTSA) hub. Screening events are hosted in partnership with faith-based institutions. Participants provide a medical history, complete a survey, and receive counseling by clinicians with referrals for follow-up care. This study aims to quantify H2H screening participant health status; identify socioeconomic, health access, and health-related barriers disproportionately promoting the onset of CVD and diabetes; and develop long-term community partnerships to enable underserved communities to influence activities across the translational research spectrum at our CTSA hub. The population served is disproportionately non-white, and uninsured, with many low-income and underserved individuals. The program was developed in partnership with our Community Advisory Board to empower this cohort to make beneficial lifestyle changes. Leveraging partnerships with faith-based institutions and community centers in at-risk New York City neighborhoods, H2H addresses the increasing burden of diabetes and CVD risk factors in vulnerable individuals while promoting community involvement in CTSA activities, serving as a model for similar initiatives.

Published
2024
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22. Activation of a non-neuronal cholinergic system in visceral white adipose tissue of obese mice and humans

Author

Ilenia Severi, Jessica Perugini, Chiara Ruocco, Lara Coppi, Silvia Pedretti, Eleonora Di Mercurio, Martina Senzacqua, Maurizio Ragni, Gabriele Imperato, Alessandra Valerio, Nico Mitro, Maurizio Crestani, Enzo Nisoli, and Antonio Giordano

Subjects
Acetylcholine, Obesity, Insulin resistance, Choline, Inflammation, Macrophages, Internal medicine, RC31-1245
Abstract

Background and objectives: Since white adipose tissue (WAT) lacks parasympathetic cholinergic innervation, the source of the acetylcholine (ACh) acting on white adipocyte cholinergic receptors is unknown. This study was designed to identify ACh-producing cells in mouse and human visceral WAT and to determine whether a non-neuronal cholinergic system becomes activated in obese inflamed WAT. Methods: Mouse epididymal WAT (eWAT) and human omental fat were studied in normal and obese subjects. The expression of the key molecules involved in cholinergic signaling was evaluated by qRT-PCR and western blotting whereas their tissue distribution and cellular localization were investigated by immunohistochemistry, confocal microscopy and in situ hybridization. ACh levels were measured by liquid chromatography/tandem mass spectrometry. The cellular effects of ACh were assessed in cultured human multipotent adipose-derived stem cell (hMADS) adipocytes. Results: In mouse eWAT, diet-induced obesity modulated the expression of key cholinergic molecular components and, especially, raised the expression of choline acetyltransferase (ChAT), the ACh-synthesizing enzyme, which was chiefly detected in interstitial macrophages, in macrophages forming crown-like structures (CLSs), and in multinucleated giant cells (MGCs). The stromal vascular fraction of obese mouse eWAT contained significantly higher ACh and choline levels than that of control mice. ChAT was undetectable in omental fat from healthy subjects, whereas it was expressed in a number of interstitial macrophages, CLSs, and MGCs from some obese individuals. In hMADS adipocytes stressed with tumor necrosis factor α, ACh, alone or combined with rivastigmine, significantly blunted monocyte chemoattractant protein 1 and interleukin 6 expression, it partially but significantly, restored adiponectin and GLUT4 expression, and promoted glucose uptake. Conclusions: In mouse and human visceral WAT, obesity induces activation of a macrophage-dependent non-neuronal cholinergic system that is capable of exerting anti-inflammatory and insulin-sensitizing effects on white adipocytes.

Published
2024
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23. Tests of General Relativity with Binary Black Holes from the second LIGO-Virgo Gravitational-Wave Transient Catalog

Author

The LIGO Scientific Collaboration, the Virgo Collaboration, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arène, M., Arnaud, N., Aronson, S. M., Arun, K. G., Asali, Y., Ascenzi, S., Ashton, G., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Avendano, V., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Baer, A. M., Bagnasco, S., Baird, J., Ball, M., Ballardin, G., Ballmer, S. W., Bals, A., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barnum, S., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Becher, B. R., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Beniwal, D., Benjamin, M. G., Benkel, R., Bennett, T. F., Bentley, J. D., Bergamin, F., Berger, B. K., Bergmann, G., Bernuzzi, S., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Blanch, O., Bobba, F., Bode, N., Boer, M., Boetzel, Y., Bogaert, G., Boldrini, M., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Borhanian, S., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brighenti, F., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Byer, R. L., Cabero, M., Cadonati, L., Caesar, M., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Cannon, K. C., Cao, H., Cao, J., Carapella, G., Carbognani, F., Carney, M. F., Carpinelli, M., Carullo, G., Carver, T. L., Diaz, J. Casanueva, Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakravarti, K., Chan, C. -L., Chan, C., Chandra, K., Chanial, P., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, D., Chaturvedi, M., Chatziioannou, K., Chen, A., Chen, H. Y., Chen, X., Chen, Y., Cheng, H. -P., Cheong, C. K., Chia, H. Y., Chiadini, F., Chierici, R., Chincarini, A., Chiummo, A., Cho, G., Cho, H. S., Cho, M., Choate, S., Christensen, N., Chu, Q., Chua, S., Chung, K. W., Chung, S., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, E. N., Clark, J. A., Clarke, L., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Cohadon, P. -F., Cohen, D. E., Colleoni, M., Collette, C. G., Collins, C., Colpi, M., Constancio Jr., M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coughlin, S. B., Coulon, J. -P., Countryman, S. T., Couvares, P., Covas, P. B., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Cury{l}o, M., Canton, T. Dal, Dálya, G., Dana, A., DaneshgaranBajastani, L. M., D'Angelo, B., Danilishin, S. L., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Daw, E. J., Dean, R., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Del Pozzo, W., DeMarchi, L. M., De Matteis, F., D'Emilio, V., Demos, N., Denker, T., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., de Varona, O., Dhani, A., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz Jr., M., Didio, N. A., Dietrich, T., Di Fiore, L., DiFronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., D'Onofrio, L., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Downes, T. P., Drago, M., Driggers, J. C., Du, Z., Ducoin, J. -G., Dudi, R., Dupej, P., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Easter, P. J., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etienne, Z. B., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farah, A. M., Farinon, S., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Feng, F., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, I., Fiorucci, D., Fishbach, M., Fisher, R. P., Fishner, J. M., Fittipaldi, R., Fitz-Axen, M., Fiumara, V., Flaminio, R., Floden, E., Flynn, E., Fong, H., Font, J. A., Forsyth, P. W. F., Fournier, J. -D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gaonkar, S. G., Garaventa, B., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Gemme, G., Gennai, A., George, D., George, J., George, R. N., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giacomazzo, B., Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Gill, K., Giri, P., Glanzer, J., Gleckl, A. E., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gossan, S. E., Gosselin, M., Gouaty, R., Grace, B., Grado, A., Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, E. M., Griggs, H. L., Grignani, G., Grimaldi, A., Grimes, E., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guerrero, J. G., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, P., Gustafson, E. K., Gustafson, R., Guzman, F., Haegel, L., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hannuksela, O., Hansen, H., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Hasskew, R. K., Haster, C. -J., Haughian, K., Hayes, F. J., Healy, J., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Hennig, M. H., Vivanco, F. Hernandez, Heurs, M., Hild, S., Hill, P., Hines, A. S., Hochheim, S., Hofgard, E., Hofman, D., Hohmann, J. N., Holgado, A. M., Holland, N. A., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hopkins, P., Horst, C., Hough, J., Howell, E. J., Hoy, C. G., Hoyland, D., Huang, Y., Hübner, M. T., Huddart, A. D., Huerta, E. A., Hughey, B., Hui, V., Husa, S., Huttner, S. H., Hutzler, B. M., Huxford, R., Huynh-Dinh, T., Idzkowski, B., Iess, A., Imperato, S., Inchauspe, H., Ingram, C., Intini, G., Isi, M., Iyer, B. R., JaberianHamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jani, K., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jeunon, M., Jiang, J., Johns, G. R., Johnson-McDaniel, N. K., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Junker, J., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Kapasi, D. P., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kawabe, K., Kéfélian, F., Keitel, D., Key, J. 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Subjects
General Relativity and Quantum Cosmology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Gravitational waves enable tests of general relativity in the highly dynamical and strong-field regime. Using events detected by LIGO-Virgo up to 1 October 2019, we evaluate the consistency of the data with predictions from the theory. We first establish that residuals from the best-fit waveform are consistent with detector noise, and that the low- and high-frequency parts of the signals are in agreement. We then consider parametrized modifications to the waveform by varying post-Newtonian and phenomenological coefficients, improving past constraints by factors of ${\sim}2$; we also find consistency with Kerr black holes when we specifically target signatures of the spin-induced quadrupole moment. Looking for gravitational-wave dispersion, we tighten constraints on Lorentz-violating coefficients by a factor of ${\sim}2.6$ and bound the mass of the graviton to $m_g \leq 1.76 \times 10^{-23} \mathrm{eV}/c^2$ with 90% credibility. We also analyze the properties of the merger remnants by measuring ringdown frequencies and damping times, constraining fractional deviations away from the Kerr frequency to $\delta \hat{f}_{220} = 0.03^{+0.38}_{-0.35}$ for the fundamental quadrupolar mode, and $\delta \hat{f}_{221} = 0.04^{+0.27}_{-0.32}$ for the first overtone; additionally, we find no evidence for postmerger echoes. Finally, we determine that our data are consistent with tensorial polarizations through a template-independent method. When possible, we assess the validity of general relativity based on collections of events analyzed jointly. We find no evidence for new physics beyond general relativity, for black hole mimickers, or for any unaccounted systematics., Comment: 24 pages + appendices, 19 figures; journal version

Published
2020
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24. Population Properties of Compact Objects from the Second LIGO-Virgo Gravitational-Wave Transient Catalog

Author

The LIGO Scientific Collaboration, the Virgo Collaboration, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arène, M., Arnaud, N., Aronson, S. M., Arun, K. G., Asali, Y., Ascenzi, S., Ashton, G., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Avendano, V., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Baer, A. M., Bagnasco, S., Baird, J., Ball, M., Ballardin, G., Ballmer, S. W., Bals, A., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barnum, S., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Becher, B. R., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Beniwal, D., Benjamin, M. G., Bennett, T. F., Bentley, J. D., Bergamin, F., Berger, B. K., Bergmann, G., Bernuzzi, S., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Blanch, O., Bobba, F., Bode, N., Boer, M., Boetzel, Y., Bogaert, G., Boldrini, M., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brighenti, F., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buscicchio, R., Buskulic, D., Byer, R. L., Cabero, M., Cadonati, L., Caesar, M., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Cannon, K. C., Cao, H., Cao, J., Carapella, G., Carbognani, F., Carney, M. F., Carpinelli, M., Carullo, G., Carver, T. L., Diaz, J. Casanueva, Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakravarti, K., Chan, C. -L., Chan, C., Chandra, K., Chanial, P., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, D., Chattopadhyay, D., Chaturvedi, M., Chatziioannou, K., Chen, A., Chen, H. 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Subjects
Astrophysics - High Energy Astrophysical Phenomena, General Relativity and Quantum Cosmology
Abstract

We report on the population of the 47 compact binary mergers detected with a false-alarm rate 1/yr in the second LIGO--Virgo Gravitational-Wave Transient Catalog, GWTC-2. We observe several characteristics of the merging binary black hole (BBH) population not discernible until now. First, we find that the primary mass spectrum contains structure beyond a power-law with a sharp high-mass cut-off; it is more consistent with a broken power law with a break at $39.7^{+20.3}_{-9.1}\,M_\odot$, or a power law with a Gaussian feature peaking at $33.1^{+4.0}_{-5.6}\,M_\odot$ (90\% credible interval). While the primary mass distribution must extend to $\sim65\,M_\odot$ or beyond, only $2.9^{+3.5}_{1.7}\%$ of systems have primary masses greater than $45\,M_\odot$. Second, we find that a fraction of BBH systems have component spins misaligned with the orbital angular momentum, giving rise to precession of the orbital plane. Moreover, 12% to 44% of BBH systems have spins tilted by more than $90^\circ$, giving rise to a negative effective inspiral spin parameter $\chi_\mathrm{eff}$. Under the assumption that such systems can only be formed by dynamical interactions, we infer that between 25% and 93% of BBH with non-vanishing $|\chi_\mathrm{eff}| > 0.01$ are dynamically assembled. Third, we estimate merger rates, finding $\mathcal{R}_\text{BBH} = 23.9^{+14.3}_{8.6}$ Gpc$^{-3}$ yr$^{-1}$ for BBH and $\mathcal{R}_\text{BNS}= 320^{+490}_{-240}$ Gpc$^{-3}$ yr$^{-1}$ for binary neutron stars. We find that the BBH rate likely increases with redshift ($85\%$ credibility), but not faster than the star-formation rate ($86\%$ credibility). Additionally, we examine recent exceptional events in the context of our population models, finding that the asymmetric masses of GW190412 and the high component masses of GW190521 are consistent with our models, but the low secondary mass of GW190814 makes it an outlier., Comment: 53 pages, including 24 pages main text, 18 pages appendix, 30 figures

Published
2020
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25. GWTC-2: Compact Binary Coalescences Observed by LIGO and Virgo During the First Half of the Third Observing Run

Author

Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akcay, S., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arène, M., Arnaud, N., Aronson, S. M., Arun, K. G., Asali, Y., Ascenzi, S., Ashton, G., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Avendano, V., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Baer, A. M., Bagnasco, S., Baird, J., Ball, M., Ballardin, G., Ballmer, S. W., Bals, A., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barnum, S., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Becher, B. R., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Beniwal, D., Benjamin, M. G., Bennett, T. F., Bentley, J. D., Bergamin, F., Berger, B. K., Bergmann, G., Bernuzzi, S., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Blanch, O., Bobba, F., Bode, N., Boer, M., Boetzel, Y., Bogaert, G., Boldrini, M., Bondu, F., Bonnand, R., Bonilla, E., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brighenti, F., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buscicchio, R., Buskulic, D., Byer, R. L., Cabero, M., Cadonati, L., Caesar, M., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Cannon, K. C., Cao, H., Cao, J., Carapella, G., Carbognani, F., Carney, M. F., Carpinelli, M., Carullo, G., Carver, T. L., Diaz, J. Casanueva, Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakravarti, K., Chan, C. -L., Chan, C., Chandra, K., Chanial, P., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, D., Chattopadhyay, D., Chaturvedi, M., Chatziioannou, K., Chen, A., Chen, H. Y., Chen, X., Chen, Y., Cheng, H. -P., Cheong, C. K., Chia, H. Y., Chiadini, F., Chierici, R., Chincarini, A., Chiummo, A., Cho, G., Cho, H. S., Cho, M., Choate, S., Christensen, N., Chu, Q., Chua, S., Chung, K. W., Chung, S., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, E. N., Clark, J. A., Clarke, L., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Cohadon, P. -F., Cohen, D. E., Colleoni, M., Collette, C. G., Collins, C., Colpi, M., Constancio Jr., M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coughlin, S. B., Coulon, J. -P., Countryman, S. T., Cousins, B., Couvares, P., Covas, P. B., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Curylo, M., Canton, T. Dal, Dálya, G., Dana, A., DaneshgaranBajastani, L. M., D'Angelo, B., Danila, B., Danilishin, S. L., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Daw, E. J., Dean, R., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Del Pozzo, W., DeMarchi, L. M., De Matteis, F., D'Emilio, V., Demos, N., Denker, T., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., de Varona, O., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz Jr., M., Didio, N. A., Dietrich, T., Di Fiore, L., DiFronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., D'Onofrio, L., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Downes, T. P., Drago, M., Driggers, J. C., Du, Z., Ducoin, J. -G., Dupej, P., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Easter, P. J., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etienne, Z. B., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farah, A. M., Farinon, S., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Feng, F., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, I., Fiorucci, D., Fishbach, M., Fisher, R. P., Fishner, J. M., Fittipaldi, R., Fitz-Axen, M., Fiumara, V., Flaminio, R., Floden, E., Flynn, E., Fong, H., Font, J. A., Forsyth, P. W. F., Fournier, J. -D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gaonkar, S. G., Garaventa, B., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Gemme, G., Gennai, A., George, D., George, J., George, R. N., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giacomazzo, B., Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Gill, K., Giri, P., Glanzer, J., Gleckl, A. E., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gossan, S. E., Gosselin, M., Gouaty, R., Grace, B., Grado, A., Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, E. M., Griggs, H. L., Grignani, G., Grimaldi, A., Grimes, E., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guerrero, J. G., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, P., Gustafson, E. K., Gustafson, R., Guzman, F., Haegel, L., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hannuksela, O., Hansen, H., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Hasskew, R. K., Haster, C. -J., Haughian, K., Hayes, F. J., Healy, J., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Hennig, M. H., Vivanco, F. Hernandez, Heurs, M., Hild, S., Hill, P., Hines, A. S., Hochheim, S., Hofgard, E., Hofman, D., Hohmann, J. N., Holgado, A. M., Holland, N. A., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hopkins, P., Horst, C., Hough, J., Howell, E. J., Hoy, C. G., Hoyland, D., Huang, Y., Hübner, M. T., Huddart, A. D., Huerta, E. A., Hughey, B., Hui, V., Husa, S., Huttner, S. H., Hutzler, B. M., Huxford, R., Huynh-Dinh, T., Idzkowski, B., Iess, A., Imperato, S., Inchauspe, H., Ingram, C., Intini, G., Isi, M., Iyer, B. R., JaberianHamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jani, K., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jeunon, M., Jiang, J., Johns, G. R., Johnson-McDaniel, N. K., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Junker, J., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Kapasi, D. P., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kawabe, K., Kéfélian, F., Keitel, D., Key, J. S., Khadka, S., Khalili, F. Y., Khan, I., Khan, S., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, G. J., Kim, J. C., Kim, K., Kim, W. S., Kim, Y. -M., Kimball, C., King, P. J., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kleybolte, L., Klimenko, S., Knowles, T. D., Knyazev, E., Koch, P., Koehlenbeck, S. M., Koekoek, G., Koley, S., Kolstein, M., Komori, K., Kondrashov, V., Kontos, A., Koper, N., Korobko, M., Korth, W. Z., Kovalam, M., Kozak, D. B., Krämer, C., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kuns, K., Kwang, S., Lackey, B. D., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., Lanza, R. K., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lehmann, J., Leon, E., Leroy, N., Letendre, N., Levin, Y., Li, A., Li, J., Li, K. J. L., Li, T. G. F., Li, X., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, J., Liu, X., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., London, L. T., Longo, A., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lousto, C. O., Lovelace, G., Lück, H., Lumaca, D., Lundgren, A. P., Ma, Y., Macas, R., MacInnis, M., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magaña-Sandoval, F., Magazzù, C., Magee, R. M., Majorana, E., Maksimovic, I., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, M., Martinez, V., Martynov, D. V., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Mateu-Lucena, M., Matichard, F., Matiushechkina, M., Mavalvala, N., Maynard, E., McCann, J. J., McCarthy, R., McClelland, D. E., McCormick, S., McCuller, L., McGuire, S. C., McIsaac, C., McIver, J., McManus, D. J., McRae, T., McWilliams, S. T., Meacher, D., Meadors, G. D., Mehmet, M., Mehta, A. K., Melatos, A., Melchor, D. A., Mendell, G., Menendez-Vazquez, A., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Middleton, H., Milano, L., Miller, A. L., Millhouse, M., Mills, J. C., Milotti, E., Milovich-Goff, M. C., Minazzoli, O., Minenkov, Y., Mir, Ll. M., Mishkin, A., Mishra, C., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Mo, G., Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina, I., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., Moreno, G., Morisaki, S., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, Soma, Mukherjee, Subroto, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Nadji, S. L., Nagar, A., Nardecchia, I., Naticchioni, L., Nayak, R. K., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neunzert, A., Nitz, A. H., Ng, K. Y., Ng, S., Nguyen, C., Nguyen, P., Nguyen, T., Nichols, S. A., Nissanke, S., Nocera, F., Noh, M., North, C., Nothard, D., Nuttall, L. K., Oberling, J., O'Brien, B. D., O'Dell, J., Oganesyan, G., Ogin, G. H., Oh, J. J., Oh, S. H., Ohme, F., Ohta, H., Okada, M. A., Olivetto, C., Oppermann, P., Oram, R. J., O'Reilly, B., Ormiston, R. G., Ortega, L. F., O'Shaughnessy, R., Ossokine, S., Osthelder, C., Ottaway, D. J., Overmier, H., Owen, B. J., Pace, A. E., Pagano, G., Page, M. A., Pagliaroli, G., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pan, H., Panda, P. K., Pang, T. H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Paolone, A., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patel, M., Patricelli, B., Payne, E., Pechsiri, T. C., Pedraza, M., Pegoraro, M., Pele, A., Penn, S., Perego, A., Perez, C. J., Périgois, C., Perreca, A., Perriès, S., Petermann, J., Petterson, D., Pfeiffer, H. P., Pham, K. A., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierini, L., Pierro, V., Pillant, G., Pilo, F., Pinard, L., Pinto, I. M., Piotrzkowski, K., Pirello, M., Pitkin, M., Placidi, E., Plastino, W., Pluchar, C., Poggiani, R., Polini, E., Pong, D. Y. T., Ponrathnam, S., Popolizio, P., Porter, E. K., Poverman, A., Powell, J., Pracchia, M., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Prestegard, T., Principe, M., Prodi, G. A., Prokhorov, L., Prosposito, P., Prudenzi, L., Puecher, A., Punturo, M., Puosi, F., Puppo, P., Pürrer, M., Qi, H., Quetschke, V., Quinonez, P. J., Quitzow-James, R., Raab, F. J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rafferty, H., Rail, S. X., Raja, S., Rajan, C., Rajbhandari, B., Rakhmanov, M., Ramirez, K. E., Ramirez, T. D., Ramos-Buades, A., Rana, J., Rao, K., Rapagnani, P., Rapol, U. D., Ratto, B., Raymond, V., Razzano, M., Read, J., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Rettegno, P., Ricci, F., Richardson, C. J., Richardson, J. W., Richardson, L., Ricker, P. M., Riemenschneider, G., Riles, K., Rizzo, M., Robertson, N. A., Robinet, F., Rocchi, A., Rocha, J. A., Rodriguez, S., Rodriguez-Soto, R. D., Rolland, L., Rollins, J. G., Roma, V. J., Romanelli, M., Romano, R., Romel, C. L., Romero, A., Romero-Shaw, I. M., Romie, J. H., Ronchini, S., Rose, C. A., Rose, D., Rose, K., Rosell, M. J. B., Rosińska, D., Rosofsky, S. G., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, Santosh, Roy, Soumen, Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Sakellariadou, M., Salafia, O. S., Salconi, L., Saleem, M., Samajdar, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Sandles, L., Santiago, K. A., Santos, E., Saravanan, T. R., Sarin, N., Sassolas, B., Sathyaprakash, B. S., Sauter, O., Savage, R. L., Savant, V., Sawant, D., Sayah, S., Schaetzl, D., Schale, P., Scheel, M., Scheuer, J., Schindler-Tyka, A., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schönbeck, A., Schreiber, E., Schulte, B. W., Schutz, B. F., Schwarm, O., Schwartz, E., Scott, J., Scott, S. M., Seglar-Arroyo, M., Seidel, E., Sellers, D., Sengupta, A. S., Sennett, N., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaffer, T., Shahriar, M. S., Sharifi, S., Sharma, A., Sharma, P., Shawhan, P., Shen, H., Shikauchi, M., Shink, R., Shoemaker, D. H., Shoemaker, D. M., Shukla, K., ShyamSundar, S., Sieniawska, M., Sigg, D., Singer, L. P., Singh, D., Singh, N., Singha, A., Singhal, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, R. J. E., Somala, S. N., Son, E. J., Soni, K., Soni, S., Sorazu, B., Sordini, V., Sorrentino, F., Sorrentino, N., Soulard, R., Souradeep, T., Sowell, E., Spencer, A. P., Spera, M., Srivastava, A. K., Srivastava, V., Staats, K., Stachie, C., Steer, D. A., Steinhoff, J., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stevenson, S. P., Stolle-McAllister, G., Stops, D. J., Stover, M., Strain, K. A., Stratta, G., Strunk, A., Sturani, R., Stuver, A. L., Südbeck, J., Sudhagar, S., Sudhir, V., Suh, H. G., Summerscales, T. Z., Sun, H., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Swinkels, B. L., Szczepańczyk, M. J., Tacca, M., Tait, S. C., Talbot, C., Tanasijczuk, A. J., Tanner, D. B., Tao, D., Tapia, A., Martin, E. N. Tapia San, Tasson, J. D., Taylor, R., Tenorio, R., Terkowski, L., Thirugnanasambandam, M. P., Thomas, L. M., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tiwari, Shubhanshu, Tiwari, Srishti, Tiwari, V., Toland, K., Tolley, A. E., Tonelli, M., Tornasi, Z., Torres-Forné, A., Torrie, C. I., Melo, I. Tosta e, Töyrä, D., Tran, A. T., Trapananti, A., Travasso, F., Traylor, G., Tringali, M. C., Tripathee, A., Trovato, A., Trudeau, R. J., Tsai, D. S., Tsang, K. W., Tse, M., Tso, R., Tsukada, L., Tsuna, D., Tsutsui, T., Turconi, M., Ubhi, A. S., Udall, R. P., Ueno, K., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Utina, A. C., Vahlbruch, H., Vajente, G., Vajpeyi, A., Valdes, G., Valentini, M., Valsan, V., van Bakel, N., van Beuzekom, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., van der Schaaf, L., van Heijningen, J. V., Vardaro, M., Vargas, A. F., Varma, V., Vass, S., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Venneberg, J., Venugopalan, G., Verkindt, D., Verma, Y., Veske, D., Vetrano, F., Viceré, A., Viets, A. D., Vijaykumar, A., Villa-Ortega, V., Vinet, J. -Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Wade, M., Walet, R. C., Walker, M., Wallace, G. S., Wallace, L., Walsh, S., Wang, J. Z., Wang, S., Wang, W. H., Wang, Y. F., Ward, R. L., Warner, J., Was, M., Washington, N. Y., Watchi, J., Weaver, B., Wei, L., Weinert, M., Weinstein, A. J., Weiss, R., Wellmann, F., Wen, L., Weßels, P., Westhouse, J. W., Wette, K., Whelan, J. T., White, D. D., White, L. V., Whiting, B. F., Whittle, C., Wilken, D. M., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wilson, D. J., Wimmer, M. H., Winkler, W., Wipf, C. C., Woan, G., Woehler, J., Wofford, J. K., Wong, I. C. F., Wrangel, J., Wright, J. L., Wu, D. S., Wysocki, D. M., Xiao, L., Yamamoto, H., Yang, L., Yang, Y., Yang, Z., Yap, M. J., Yeeles, D. W., Yoon, A., Yu, Hang, Yu, Haocun, Yuen, S. H. R., Zadrożny, A., Zanolin, M., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, R., Zhang, T., Zhao, C., Zhao, G., Zheng, Y., Zhou, M., Zhou, Z., Zhu, X. J., Zimmerman, A. B., Zlochower, Y., Zucker, M. E., and Zweizig, J.

Subjects
General Relativity and Quantum Cosmology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report on gravitational wave discoveries from compact binary coalescences detected by Advanced LIGO and Advanced Virgo in the first half of the third observing run (O3a) between 1 April 2019 15:00 UTC and 1 October 2019 15:00. By imposing a false-alarm-rate threshold of two per year in each of the four search pipelines that constitute our search, we present 39 candidate gravitational wave events. At this threshold, we expect a contamination fraction of less than 10%. Of these, 26 candidate events were reported previously in near real-time through GCN Notices and Circulars; 13 are reported here for the first time. The catalog contains events whose sources are black hole binary mergers up to a redshift of ~0.8, as well as events whose components could not be unambiguously identified as black holes or neutron stars. For the latter group, we are unable to determine the nature based on estimates of the component masses and spins from gravitational wave data alone. The range of candidate events which are unambiguously identified as binary black holes (both objects $\geq 3~M_\odot$) is increased compared to GWTC-1, with total masses from $\sim 14~M_\odot$ for GW190924_021846 to $\sim 150~M_\odot$ for GW190521. For the first time, this catalog includes binary systems with significantly asymmetric mass ratios, which had not been observed in data taken before April 2019. We also find that 11 of the 39 events detected since April 2019 have positive effective inspiral spins under our default prior (at 90% credibility), while none exhibit negative effective inspiral spin. Given the increased sensitivity of Advanced LIGO and Advanced Virgo, the detection of 39 candidate events in ~26 weeks of data (~1.5 per week) is consistent with GWTC-1., Comment: This version updates with minor revisions to typographical errors. We would also like to call attention to the updated parameter estimation samples data release here: https://dcc.ligo.org/LIGO-P2000223/public

Published
2020
Full Text
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26. Gravitational-wave constraints on the equatorial ellipticity of millisecond pulsars

Author

The LIGO Scientific Collaboration, the Virgo Collaboration, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arène, M., Arnaud, N., Aronson, S. M., Arun, K. G., Asali, Y., Ascenzi, S., Ashton, G., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Avendano, V., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Baer, A. M., Bagnasco, S., Baird, J., Ball, M., Ballardin, G., Ballmer, S. W., Bals, A., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barnum, S., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Becher, B. R., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Beniwal, D., Benjamin, M. G., Bennett, T. F., Bentley, J. D., Bergamin, F., Berger, B. K., Bergmann, G., Bernuzzi, S., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Blanch, O., Bobba, F., Bode, N., Boer, M., Boetzel, Y., Bogaert, G., Boldrini, M., Bondu, F., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branchesi, M., Brau, J. 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J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rafferty, H., Rail, S. X., Raja, S., Rajan, C., Rajbhandari, B., Rakhmanov, M., Ramirez, K. E., Ramirez, T. D., Ramos-Buades, A., Rana, J., Rao, K., Rapagnani, P., Rapol, U. D., Ratto, B., Raymond, V., Razzano, M., Read, J., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Rettegno, P., Ricci, F., Richardson, C. J., Richardson, J. W., Richardson, L., Ricker, P. M., Riemenschneider, G., Riles, K., Rizzo, M., Robertson, N. A., Robinet, F., Rocchi, A., Rocha, J. A., Rodriguez, S., Rodriguez-Soto, R. D., Rolland, L., Rollins, J. G., Roma, V. J., Romanelli, M., Romano, R., Romel, C. L., Romero, A., Romero-Shaw, I. M., Romie, J. H., Ronchini, S., Rose, C. A., Rose, D., Rose, K., Rosińska, D., Rosofsky, S. G., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, Santosh, Roy, Soumen, Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Sakellariadou, M., Salafia, O. S., Salconi, L., Saleem, M., Samajdar, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Santiago, K. A., Santos, E., Saravanan, T. R., Sarin, N., Sassolas, B., Sauter, O., Savage, R. L., Savant, V., Sawant, D., Sayah, S., Schaetzl, D., Schale, P., Scheel, M., Scheuer, J., Schindler-Tyka, A., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schönbeck, A., Schreiber, E., Schulte, B. W., Schutz, B. F., Schwarm, O., Schwartz, E., Scott, J., Scott, S. M., Seglar-Arroyo, M., Seidel, E., Sellers, D., Sengupta, A. S., Sennett, N., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaffer, T., Shahriar, M. S., Sharifi, S., Sharma, A., Sharma, P., Shawhan, P., Shen, H., Shikauchi, M., Shink, R., Shoemaker, D. H., Shoemaker, D. M., Shukla, K., ShyamSundar, S., Sieniawska, M., Sigg, D., Singer, L. P., Singh, D., Singh, N., Singha, A., Singhal, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, R. J. E., Somala, S. N., Son, E. J., Soni, S., Sorazu, B., Sordini, V., Sorrentino, F., Sorrentino, N., Soulard, R., Souradeep, T., Sowell, E., Spencer, A. P., Spera, M., Srivastava, A. K., Srivastava, V., Staats, K., Stachie, C., Steer, D. A., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stolle-McAllister, G., Stops, D. J., Stover, M., Strain, K. A., Stratta, G., Strunk, A., Sturani, R., Stuver, A. L., Südbeck, J., Sudhagar, S., Sudhir, V., Summerscales, T. Z., Sun, H., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Swinkels, B. L., Szczepańczyk, M. J., Tacca, M., Tait, S. C., Talbot, C., Tanasijczuk, A. J., Tanner, D. B., Tao, D., Tapia, A., Martin, E. N. Tapia San, Tasson, J. D., Taylor, R., Tenorio, R., Terkowski, L., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tiwari, Shubhanshu, Tiwari, Srishti, Tiwari, V., Toland, K., Tolley, A. E., Tonelli, M., Tornasi, Z., Torres-Forné, A., Torrie, C. I., Melo, I. Tosta e, Töyrä, D., Tran, A. T., Trapananti, A., Travasso, F., Traylor, G., Tringali, M. C., Tripathee, A., Trovato, A., Trudeau, R. J., Tsai, D. S., Tsang, K. W., Tse, M., Tso, R., Tsukada, L., Tsuna, D., Tsutsui, T., Turconi, M., Ubhi, A. S., Udall, R. P., Ueno, K., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Utina, A. C., Vahlbruch, H., Vajente, G., Vajpeyi, A., Valdes, G., Valentini, M., Valsan, V., van Bakel, N., van Beuzekom, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., van der Schaaf, L., van Heijningen, J. V., Vardaro, M., Vargas, A. F., Varma, V., Vass, S., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Venneberg, J., Venugopalan, G., Verkindt, D., Verma, Y., Veske, D., Vetrano, F., Viceré, A., Viets, A. D., Villa-Ortega, V., Vinet, J. -Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Wade, M., Walet, R. C., Walker, M., Wallace, G. S., Wallace, L., Walsh, S., Wang, J. Z., Wang, S., Wang, W. H., Wang, Y. F., Ward, R. L., Warner, J., Was, M., Washington, N. Y., Watchi, J., Weaver, B., Wei, L., Weinert, M., Weinstein, A. J., Weiss, R., Wellmann, F., Wen, L., Weßels, P., Westhouse, J. W., Wette, K., Whelan, J. T., White, D. D., White, L. V., Whiting, B. F., Whittle, C., Wilken, D. M., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wilson, D. J., Wimmer, M. H., Winkler, W., Wipf, C. C., Woan, G., Woehler, J., Wofford, J. K., Wong, I. C. F., Wrangel, J., Wright, J. L., Wu, D. S., Wysocki, D. M., Xiao, L., Yamamoto, H., Yang, L., Yang, Y., Yang, Z., Yap, M. J., Yeeles, D. W., Yoon, A., Yu, Hang, Yu, Haocun, Yuen, S. H. R., Zadrożny, A., Zanolin, M., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, R., Zhang, T., Zhao, C., Zhao, G., Zhou, M., Zhou, Z., Zhu, X. J., Zucker, M. E., Zweizig, J., Keith, M. J., Lyne, A. G., Palfreyman, J., Shaw, B., Stappers, B. W., and Weltevrede, P.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, General Relativity and Quantum Cosmology
Abstract

We present a search for continuous gravitational waves from five radio pulsars, comprising three recycled pulsars (PSR J0437-4715, PSR J0711-6830, and PSR J0737-3039A) and two young pulsars: the Crab pulsar (J0534+2200) and the Vela pulsar (J0835-4510). We use data from the third observing run of Advanced LIGO and Virgo combined with data from their first and second observing runs. For the first time we are able to match (for PSR J0437-4715) or surpass (for PSR J0711-6830) the indirect limits on gravitational-wave emission from recycled pulsars inferred from their observed spin-downs, and constrain their equatorial ellipticities to be less than $10^{-8}$. For each of the five pulsars, we perform targeted searches that assume a tight coupling between the gravitational-wave and electromagnetic signal phase evolution. We also present constraints on PSR J0711-6830, the Crab pulsar and the Vela pulsar from a search that relaxes this assumption, allowing the gravitational-wave signal to vary from the electromagnetic expectation within a narrow band of frequencies and frequency derivatives., Comment: 23 pages, 6 figures, 3 tables

Published
2020
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27. The role of defense styles and psychopathological symptoms on adherence to conspiracy theories during the COVID-19 pandemic

Author

Francesca Gioia, Chiara Imperato, Valentina Boursier, Christian Franceschini, Adriano Schimmenti, and Alessandro Musetti

Subjects
Medicine, Science
Abstract

Abstract Due to the unpredictability of the COVID-19 pandemic situation, individuals felt uncertain and insecure. As a consequence, conspiracy theories flourished and quickly spread. In the current study, we examine the relationship between general and COVID-19-related conspiracy theories, cognitive reflection, psychopathological symptoms, and defense styles in a sample of Italian adults. A total of 450 participants (50.2% male; mean age = 40.89 years, SD = 12.15) took part in an online survey. Two linear regression models on the general (explained variance 22.6%) and COVID-19-related (explained variance 33.0%) conspiracy theories have been tested. Among the predictive factors, older age, mania symptoms, and immature defenses facilitate adherence to conspiracy theories; on the opposite side, higher education, cognitive reflection, and mature defenses protected from adherence to conspiracy theories. The study provides some novel findings about factors that are significantly associated with general and COVID-19-related conspiracy theories, and highlights the pivotal role of individuals’ psychological defenses in conspiracy theories.

Published
2023
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29. Pulmonary Adverse Events in Cancer Immunotherapy: Case Studies of CT Patterns

Author

Giorgio Bocchini, Maria Chiara Imperato, Tullio Valente, Salvatore Guarino, Roberta Lieto, Candida Massimo, Emanuele Muto, Federica Romano, Mariano Scaglione, Giacomo Sica, Davide Vitagliano Torre, Salvatore Masala, Marialuisa Bocchino, and Gaetano Rea

Subjects
immune-related adverse events, immune-checkpoint inhibitors, lung toxicity, organizing pneumonia, non-specific interstitial pneumonia, hypersensitivity pneumonitis, Medicine (General), R5-920
Abstract

Immune-checkpoint inhibitors have profoundly changed cancer treatment, improving the prognosis of many oncologic patients. However, despite the good efficacy of these drugs, their mechanism of action, which involves the activation of the immune system, can lead to immune-related adverse events, which may affect almost all organs. Pulmonary adverse events are relatively common, and potentially life-threatening complications may occur. The diagnosis is challenging due to the wide and non-specific spectrum of clinical and radiological manifestations. The role of the radiologist is to recognize and diagnose pulmonary immune-related adverse events, possibly even in the early stages, to estimate their extent and guide patients’ management.

Published
2024
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30. Traumatic atrial septal defect diagnosed by bedside point-of-care ultrasound

Author

Timothy J. Batchelor, MD, Nicholas S. Imperato, BS, Kathryn L. Wheel, MD, Alexander J. Rennie, BS, and Kevin R. Roth, DO

Subjects
Trauma, MVA, Atrial septal defects, POCUS, Echocardiogram, FAST, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Atrial septal defects (ASD) caused by traumatic events, specifically blunt cardiac trauma, are considered an infrequent occurrence, yet their true prevalence has been difficult to ascertain. The general lack of knowledge is likely due to the pathology being severely understudied. We present the case of a 21-year-old male who was diagnosed with ASD following a motor vehicle accident. Initial assessment utilizing the point-of-care ultrasound (POCUS) technique - focused assessment with sonography for trauma (FAST) was found to be negative for free intraperitoneal or pericardial fluid. Subsequent computed tomography displayed multiple injuries but agreed with the FAST exam findings of no fluid within the abdomen or pericardium. Later in the patient's care a dedicated POCUS transthoracic echocardiogram was performed which identified right sided heart dilatation. The patient was managed in the intensive care unit (ICU) for an extensive period but recovered sufficiently to be discharged. The plan was to repair the ASD on a non-emergent basis. This case highlights the importance and diagnostic utility of bedside POCUS. Categories: Emergency Medicine

Published
2022
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32. Spine Infection in Children

Author

Spennato, Pietro, Russo, Carmela, Cicala, Domenico, Colella, Gianluca, Carannante, Novella, Marini, Alessandra, Imperato, Alessia, Mirone, Giuseppe, Cinalli, Giuseppe, Alexiou, Georgios, editor, and Prodromou, Neofytos, editor

Published
2022
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35. Use of Impella Devices for Acute Cardiogenic Shock in the Perioperative Period of Cardiac Surgery

Author

Serge Sicouri, Vishal N. Shah, Meghan Buckley, Nicholas Imperato, Jacqueline McGee, Elena Casanova, Eric Gnall, and Konstadinos A. Plestis

Subjects
Extracorporeal Membrane Oxygenation, Shock, Cardiogenic, Heart Ventricles, Aortic Valve, Hemodynamics, Cardiac Surgical Procedures, Perioperative Period., Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

ABSTRACT Introduction: The Impella ventricular support system is a device that can be inserted percutaneously or directly across the aortic valve to unload the left ventricle. The purpose of this study is to determine the role of Impella devices in patients with acute cardiogenic shock in the perioperative period of cardiac surgery. Methods: A retrospective single-surgeon review of 11 consecutive patients who underwent placement of Impella devices in the perioperative period of cardiac surgery was performed. Patient records were evaluated for demographics, indications for placement, and postoperative outcomes. Results: Impella devices were placed for refractory cardiogenic shock preoperatively in 6 patients, intraoperatively in 4 patients, and postoperatively as a rescue in 1 patient. Seven patients received Impella CP, 1 Impella RP, 1 Impella CP and RP, and 2 Impella 5.0. Additionally, 3 patients required preoperative venovenous extracorporeal membrane oxygenation (VV-ECMO), and 1 patient required intraoperative venoarterial extracorporeal membrane oxygenation (VA-ECMO). All Impella devices were removed 1 to 28 days after implantation. Length of stay in the intensive care unit stay ranged from 2 to 53 days (average 23.9±14.6). The 30-day and 1-year mortality were 0%. Ten of 11 patients were alive at 2 years. Also, 1 patient died 18 months after surgery from complications of coronavirus disease (Covid-19). Device-related complications included varying degrees> of hemolysis in 8 patients (73%) and device malfunction in 1 patient (9%). Conclusions: The Impella ventricular support system can be combined with other mechanical support devices for additional hemodynamic support. All patients demonstrated myocardial recovery with no deaths in the perioperative period and in 1-year of follow-up. Larger studies are necessary to validate these findings.

Published
2022
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36. Clinical Practice Management of Primary Open-Angle Glaucoma in the United States: An Analysis of Real-World Evidence

Author

Imperato JS, Zou KH, Li JZ, and Hassan TA

Subjects
adherence, antiglaucoma, health care resource utilization, persistence, real-world evidence, Medicine (General), R5-920
Abstract

Joseph S Imperato,1 Kelly H Zou,1 Jim Z Li,1 Tarek A Hassan2 1Global Medical Analytics and Real-World Evidence, Viatris Inc., Canonsburg, PA, USA; 2Global Medical Affairs, Ophthalmology, Viatris Inc, Canonsburg, PA, USACorrespondence: Tarek A Hassan, Global Medical Affairs, Ophthalmology, Viatris Inc, 1000 Mylan Boulevard, Canonsburg, PA, 15317, USA, Tel +1 347 443 2850, Email tarek.hassan@viatris.comPurpose: To investigate clinical management of primary open-angle glaucoma (POAG) in the United States using real-world evidence and to examine healthcare resource utilization (HCRU), medication adherence/persistence, and procedure use.Design: A cross-sectional, retrospective analysis of Optum’s de-identified Market Clarity Dataset (July 1, 2013–December 31, 2019).Patients and Methods: Patients ≥ 18 years with POAG diagnosis and continuous enrollment for 1-year pre- and post-index were eligible and categorized into four mutually exclusive cohorts: CH1, treated with antiglaucoma medication(s) only; CH2, underwent glaucoma procedure(s) only; CH3, treated with antiglaucoma medication(s) and underwent procedure(s); and CH4, received no treatment for POAG. Adherence and persistence with antiglaucoma medications, and disease-specific HCRU were analyzed. Pairwise two-sample comparisons and multivariate regressions were conducted.Results: Examined 232,572 eligible patients (CH1=60,895; CH2=4330; CH3=6027; CH4=161,320). Prostaglandin analogs were most prescribed antiglaucoma medications (CH1: 69.7%; CH3: 62.7%), of which latanoprost was most common (CH1: 51.3%; CH3: 46.1%). Disease-specific office visits occurred in 26.3%, 78.2%, 75.0%, 23.8%, and surgical services visits occurred in 3.8%, 36.3%, 42.5%, 3.3%, in CH1-CH4, respectively. Adherence was higher (medication possession ratio: 47.1% vs 39.4%; P< 0.0001), and more patients remained persistent across 1-year post-index period in CH1 vs CH3 (25.4% vs 16.1%; P< 0.0001). Positive predictors of medication persistence included being female, ≥ 55 years, and history of dyslipidemia or thyroid disease (all P≤ 0.0003).Conclusion: Overall, 70% POAG patients might not have received antiglaucoma treatment. Since POAG is a slowly progressive blinding disease, the lack of antiglaucoma treatment and suboptimal adherence/persistence with medications are of major concerns. Targeted screening and educational approaches are needed to improve POAG management.Keywords: adherence, antiglaucoma, health care resource utilization, persistence, real-world evidence

Published
2022

37. Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia

Author

Tirtakusuma, Ricky, Szoltysek, Katarzyna, Milne, Paul, Grinev, Vasily V., Ptasinska, Anetta, Chin, Paulynn S., Meyer, Claus, Nakjang, Sirintra, Hehir-Kwa, Jayne Y., Williamson, Daniel, Cauchy, Pierre, Keane, Peter, Assi, Salam A., Ashtiani, Minoo, Kellaway, Sophie G., Imperato, Maria R., Vogiatzi, Fotini, Schweighart, Elizabeth K., Lin, Shan, Wunderlich, Mark, Stutterheim, Janine, Komkov, Alexander, Zerkalenkova, Elena, Evans, Paul, McNeill, Hesta, Elder, Alex, Martinez-Soria, Natalia, Fordham, Sarah E., Shi, Yuzhe, Russell, Lisa J., Pal, Deepali, Smith, Alex, Kingsbury, Zoya, Becq, Jennifer, Eckert, Cornelia, Haas, Oskar A., Carey, Peter, Bailey, Simon, Skinner, Roderick, Miakova, Natalia, Collin, Matthew, Bigley, Venetia, Haniffa, Muzlifah, Marschalek, Rolf, Harrison, Christine J., Cargo, Catherine A., Schewe, Denis, Olshanskaya, Yulia, Thirman, Michael J., Cockerill, Peter N., Mulloy, James C., Blair, Helen J., Vormoor, Josef, Allan, James M., Bonifer, Constanze, Heidenreich, Olaf, and Bomken, Simon

Published
2022
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41. The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice

Author

Camille Khairallah, Timothy H. Chu, Zhijuan Qiu, Jessica N. Imperato, Daniella Yang, and Brian S. Sheridan

Subjects
γδ T cells, Mucosal immunity, Immunosenescence, Listeria monocytogenes, Foodborne infection, Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6
Abstract

Abstract Background It is generally accepted that aging has detrimental effects on conventional T cell responses to systemic infections. However, most pathogens naturally invade the body through mucosal barriers. Although mucosal sites are highly enriched in unconventional immune sentinels like γδ T cells, little is currently known about the impact of aging on unconventional mucosal T cell responses. We previously established that foodborne infection with a mouse-adapted internalin A mutant Listeria monocytogenes (Lm) generates an adaptive intestinal memory CD44hi CD27neg Vγ4 T cells capable of co-producing IL-17A and IFNγ. Therefore, we used this model to evaluate the impact of aging on adaptive Vγ4 T cell responses elicited by foodborne infection. Results Foodborne Lm infection of female Balb/c and C57BL/6 mice led to an increased adaptive CD44hi CD27neg Vγ4 T cell response associated with aging. Moreover, Lm-elicited CD44hi CD27neg Vγ4 T cells maintained diverse functional subsets despite some alterations favoring IL-17A production as mice aged. In contrast to the documented susceptibility of aged mice to intravenous Lm infection, mice contained bacteria after foodborne Lm infection suggesting that elevated bacterial burden was not a major factor driving the increased adaptive CD44hi CD27neg Vγ4 T cell response associated with mouse age. However, CD44hi CD27neg Vγ4 T cells accumulated in naïve mice as they aged suggesting that an increased precursor frequency contributes to the robust Lm-elicited mucosal response observed. Body mass did not appear to have a strong positive association with CD44hi CD27neg Vγ4 T cells within age groups. Although an increased adaptive CD44hi CD27neg Vγ4 T cell response may contribute to foodborne Lm resistance of C57BL/6 mice aged 19 or more months, neither anti-TCRδ or anti-IL-17A treatment impacted Lm colonization after primary infection. These results suggest that γδTCR signaling and IL-17A are dispensable for protection after primary foodborne Lm infection consistent with the role of conventional T cells during the early innate immune response to Lm. Conclusions Lm-elicited adaptive Vγ4 T cells appear resistant to immunosenescence and memory Vγ4 T cells could be utilized to provide protective immune functions during enteric infection of aged hosts. As such, oral immunization might offer an efficient therapeutic approach to generate unconventional memory T cells in the elderly.

Published
2022
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42. Real-World Evidence Generation

Author

Imperato, Joseph S., primary, Cook, Joseph P., additional, Morgenstern, Diana, additional, Gilchrist, Kim, additional, Hassan, Tarek A., additional, Saenz, Jorge, additional, and Ducinskiene, Danute, additional

Published
2022
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43. Quantification of Airborne Particulate Matter and Trace Element Deposition on Hedera helix and Senecio cineraria Leaves.

Author

Saran, Anabel, Mendez, Mariano Javier, Much, Diego Gabriel, Imperato, Valeria, Thijs, Sofie, Vangronsveld, Jaco, and Merini, Luciano Jose

Subjects
AIR quality monitoring stations, DUST, PARTICULATE matter, ENGLISH ivy, AIR quality, AIR pollution
Abstract

In both developed and developing countries, atmospheric pollution with particulate matter (PM) remains an important issue. Despite the health effects of poor air quality, studies on air pollution are often limited by the high costs of continuous monitoring and the need for extensive sampling. Furthermore, these particles are often enriched with potentially toxic trace elements and organic pollutants. This study evaluates both the composition of atmospheric dust accumulated during a certain timespan on Hedera helix and Senecio cineraria leaves and the potential for their use as bio-monitors. The test plants were positioned near automatic air quality monitoring stations at four different sites with respectively high, moderate and low traffic intensity. The gravimetric deposition of PM10 and PM2.5 on leaves was compared with data recorded by the monitoring stations and related to the weather conditions reported by Argentina's National Meteorological Service. To determine the presence of trace elements enriching the PM deposited on leaves, two analytical techniques were applied: XRF (not destructive) and ICP (destructive). The results indicated that only in the unpaved street location (site 2) did PM10 and PM2.5 concentrations (90 µg m−3 and 9 µg m−3) in the air exceed more than five times WHO guidelines (15 µg m−3 and 5 µg m−3). However, several trace elements were found to be enriching PM deposited on leaves from all sites. Predominantly, increased concentrations of Cd, Cu, Ti, Mn, Zn and Fe were found, which were associated with construction, traffic and unpaved street sources. Furthermore, based on its capability to sequester above 2800 µg cm−2 of PM10, 2450 µg cm−2 of PM2.5 and trace elements, Senecio cineraria can be taken into consideration for adoption as a bio-monitor or even for PM mitigation. [ABSTRACT FROM AUTHOR]

Published
2024
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44. A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells

Author

Khairallah, Camille, Bettke, Julie A., Gorbatsevych, Oleksandr, Qiu, Zhijuan, Zhang, Yue, Cho, Kyungjin, Kim, Kwang Soon, Chu, Timothy H., Imperato, Jessica N., Hatano, Shinya, Romanov, Galina, Yoshikai, Yasunobo, Puddington, Lynn, Surh, Charles D., Bliska, James B., van der Velden, Adrianus W. M., and Sheridan, Brian S.

Published
2022
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45. A Black Hole Kicked at Birth: MAXI J1305-704

Author

Chase Kimball, Sam Imperato, Vicky Kalogera, Kyle A. Rocha, Zoheyr Doctor, Jeff J. Andrews, Aaron Dotter, Emmanouil Zapartas, Simone S. Bavera, Konstantinos Kovlakas, Tassos Fragos, Philipp M. Srivastava, Devina Misra, Meng Sun, and Zepei Xing

Subjects
Astrophysical black holes, Low-mass x-ray binary stars, Supernovae, Astrophysics, QB460-466
Abstract

When a compact object is formed in a binary, any mass lost during core collapse will impart a kick on the binary’s center of mass. Asymmetries in this mass loss or neutrino emission would impart an additional natal kick on the remnant black hole or neutron star, whether it was formed in a binary or in isolation. While it is well established that neutron stars receive natal kicks upon formation, it is unclear whether black holes do as well. Here, we consider the low-mass X-ray binary MAXI J1305-704, which has been reported to have a space velocity ≳200 km s ^−1 . In addition to integrating its trajectory to infer its velocity upon formation of its black hole, we account for recent estimates of its period, black hole mass, mass ratio, and donor effective temperature from photometric and spectroscopic observations. We find that if MAXI J1305-704 formed via isolated binary evolution in the thick Galactic disk, then the supernova that formed its black hole imparted a natal kick of at least 70 km s ^−1 while ejecting less than ≃1 M _⊙ with 95% confidence assuming uninformative priors on mass loss and natal kick velocity.

Published
2023
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50. Pulmonary Adverse Events in Cancer Immunotherapy: Case Studies of CT Patterns

Author

Bocchini, Giorgio, primary, Imperato, Maria Chiara, additional, Valente, Tullio, additional, Guarino, Salvatore, additional, Lieto, Roberta, additional, Massimo, Candida, additional, Muto, Emanuele, additional, Romano, Federica, additional, Scaglione, Mariano, additional, Sica, Giacomo, additional, Vitagliano Torre, Davide, additional, Masala, Salvatore, additional, Bocchino, Marialuisa, additional, and Rea, Gaetano, additional

Published
2024
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