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25 results on '"Immunotherapy -- Physiological aspects -- Health aspects"'

1. Granulocytic myeloid-derived suppressor cell activity during biofilm infection is regulated by a glycolysis/ HIF1a axis

Author

Horn, Christopher M., Arumugam, Prabhakar, Van Roy, Zachary, Heim, Cortney E., Fallet, Rachel W., Bertrand, Blake P., Shinde, Dhananjay, Thomas, Vinai C., Romanova, Svetlana G., Bronich, Tatiana K., Hartman, Curtis W., Garvin, Kevin L., and Kielian, Tammy

Subjects
Staphylococcus aureus -- Health aspects -- Physiological aspects, RNA sequencing -- Health aspects -- Physiological aspects, Genes -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Infection -- Health aspects -- Physiological aspects, Staphylococcus aureus infections -- Physiological aspects -- Health aspects, Health care industry
Abstract

Staphylococcus aureus is a leading cause of biofilm-associated prosthetic joint infection (PJI). A primary contributor to infection chronicity is an expansion of granulocytic myeloid-derived suppressor cells (G-MDSCs), which are critical for orchestrating the antiinflammatory biofilm milieu. Single-cell sequencing and bioinformatic metabolic algorithms were used to explore the link between G-MDSC metabolism and S. aureus PJI outcome. Glycolysis and the hypoxia response through HIF1a were significantly enriched in G-MDSCs. Interfering with both pathways in vivo, using a 2- deoxyglucose nanopreparation and granulocyte-targeted Hif1a conditional KO mice, respectively, attenuated G-MDSC-mediated immunosuppression and reduced bacterial burden in a mouse model of S. aureus PJI. In addition, single-cell RNA-Seq (scRNA-Seq) analysis of granulocytes from PJI patients also showed an enrichment in glycolysis and hypoxia- response genes. These findings support the importance of a glycolysis/HIF1a axis in promoting G-MDSC antiinflammatory activity and biofilm persistence during PJI., Introduction Staphylococcus aureus is a leading cause of healthcare-and community-associated infections (1). This is due, in part, to numerous virulence factors that allow the bacterium to adapt and thrive in [...]

Published
2024
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3. Levitox Reviews: An In-Depth Analysis of Ingredients, Efficacy, and Safety Concerns for Parasite Removal

Subjects
Parasitic diseases -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Dietary supplements -- Physiological aspects -- Health aspects, News, opinion and commentary
Abstract

Byline: DNA Web Team A nutritional supplement called Levitox is advertised as assisting the body in preventing parasite infections and promoting general health. It is advertised as a natural remedy [...]

Published
2024

4. 'Therapy' you can do at home 'boosts immune system and helps sleep'; Cold therapy has become increasingly popular, with the benefits including reducing inflammation, improving immunity and increasing the metabolism

Subjects
Immunotherapy -- Physiological aspects -- Health aspects, Sleep -- Health aspects -- Physiological aspects, General interest, News, opinion and commentary
Abstract

Byline: By, Steven Smith The idea of an ice bath might not be something many of us think about. Perhaps it's something you'd do once on a weekend away. But [...]

Published
2024

5. Data from Wuhan University Advance Knowledge in Cancer Gene Therapy (Tuning Cellular Metabolism for Cancer Virotherapy)

Subjects
Gene therapy -- Health aspects -- Physiological aspects, Immunotherapy -- Physiological aspects -- Health aspects, Cancer -- Genetic aspects, Business, Health, Health care industry
Abstract

2024 JUL 2 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Biotechnology - Cancer Gene Therapy. According to news reporting out [...]

Published
2024

6. Delicious drink can stop bloating and boost immunity over Christmas; Wellness shots could be beneficial this Christmas period to aid with debloating, weight loss, energy boosting, boosting our metabolism, and help those suffering with seasonal flu

Subjects
Immunotherapy -- Physiological aspects -- Health aspects, Influenza -- Health aspects -- Physiological aspects, Weight loss -- Physiological aspects -- Health aspects, General interest, News, opinion and commentary
Abstract

Byline: By, Melanie Kaidan & Lucy Marshall Wellness shots have taking the world by storm and this Christmas one immunity boosting drink could help you debloat. It's no secret that [...]

Published
2024

7. Lactose and its derivatives are a new class of immune checkpoint inhibitors for cancer therapy

Subjects
T cells -- Physiological aspects -- Health aspects, Antineoplastic agents -- Health aspects -- Physiological aspects, Protein binding -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Cancer -- Care and treatment -- Drug therapy, Membrane proteins -- Physiological aspects -- Health aspects, Lactose -- Physiological aspects -- Health aspects, Antimitotic agents -- Health aspects -- Physiological aspects, Health
Abstract

2024 JAN 3 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- According to news reporting based on a preprint abstract, our journalists obtained the following quote [...]

Published
2024

8. Investigators from Soochow University Have Reported New Data on Cancer Therapy (Radioactive Nano-oxygen Generator Enhance Anti-tumor Radio-immunotherapy By Regulating Tumor Microenvironment and Reducing Proliferation)

Subjects
Antineoplastic agents -- Health aspects -- Physiological aspects, Immunotherapy -- Physiological aspects -- Health aspects, Cancer -- Drug therapy, Radiotherapy -- Health aspects -- Physiological aspects, Antimitotic agents -- Health aspects -- Physiological aspects, Health
Abstract

2022 MAY 18 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- A new study on Drugs and Therapies - Cancer Therapy is now available. According to [...]

Published
2022

9. Physiology of fever

Author

Broom, Mark

Subjects
United States. National Institutes of Health -- Management, Children -- Diseases, Medical research -- Physiological aspects -- Health aspects, Medicine, Experimental -- Physiological aspects -- Health aspects, Heating -- Equipment and supplies, Immunotherapy -- Physiological aspects -- Health aspects, Immunity -- Physiological aspects -- Health aspects, Infection -- Physiological aspects -- Health aspects, Nursing -- Physiological aspects -- Health aspects, Catecholamines -- Physiological aspects -- Health aspects, Nurses -- Physiological aspects -- Health aspects, Company business management, Family and marriage, Health, Health care industry
Abstract

Summary Knowing how the body reacts to the presence of pathogens allows healthcare professionals to make informed decisions about what action to take in caring for the child with fever. [...]

Published
2007

10. Reports from Comenius University Advance Knowledge in Gonadotropin Therapy (Are GnRH and FSH potentially damaging factors in the cardiovascular system?)

Subjects
Physical fitness -- Physiological aspects -- Health aspects, Follicle-stimulating hormone -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Health
Abstract

2018 AUG 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Drugs and Therapies - Gonadotropin Therapy have been [...]

Published
2018

11. Reports on Cancer from St. Louis University Provide New Insights (Targeting Citrate As a Novel Therapeutic Strategy In Cancer Treatment)

Subjects
Cancer treatment -- Physiological aspects -- Health aspects, Metabolites -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Cancer cells, Finance, Melanoma, Editors, Health, Saint Louis University
Abstract

2020 MAR 4 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Fresh data on Cancer are presented in a new report. According to news reporting originating [...]

Published
2020

12. Studies from Soonchunhyang University Seoul Hospital Yield New Data on Cancer (Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy)

Subjects
Cancer -- Physiological aspects -- Health aspects, Cancer research -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Heat shock proteins -- Physiological aspects -- Health aspects, Antineoplastic agents -- Research -- Physiological aspects -- Health aspects, Proteins -- Physiological aspects -- Health aspects, Homeostasis, Editors, Health
Abstract

2020 JAN 8 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Current study results on Cancer have been published. According to news reporting originating in Seoul, [...]

Published
2020

13. Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy

Author

Meazza, Raffaella, Azzarone, Bruno, Orengo, Anna Maria, and Ferrini, Silvano

Subjects
Physiological aspects, Research, Health aspects, Killer cells -- Physiological aspects -- Health aspects, Cytokines -- Physiological aspects -- Health aspects, Cell physiology -- Research, Immunotherapy -- Physiological aspects -- Health aspects
Abstract

1. Background: The Common-Gamma Chain Cytokine Family Cytokines are soluble mediators of intercellular signals and play an essential role in the activation and regulation of both adaptive and innate immunity. [...], NK cells are components of the innate immunity system and play an important role as a first-line defense mechanism against viral infections and in tumor immune surveillance. Their development and their functional activities are controlled by several factors among which cytokines sharing the usage of the common cytokine-receptor gamma chain play a pivotal role. In particular, IL-2, IL-7, IL-15, and IL-21 are the members of this family predominantly involved in NK cell biology. In this paper, we will address their role in NK cell ontogeny, regulation of functional activities, development of specialized cell subsets, and acquisition of memory-like functions. Finally, the potential application of these cytokines as recombinant molecules to NK cell-based immunotherapy approaches will be discussed.

Published
2011
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14. Scientists develop new immunotherapy

Author

Marino, Shirley

Subjects
Cancer vaccines -- Research -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Scientists -- Physiological aspects -- Health aspects, T cells -- Physiological aspects -- Health aspects, News, opinion and commentary, Sports and fitness
Abstract

Byline: SHIRLEY MARINO PUBLIC DOMAIN Therapeutic cancer vaccine is a commonly used treatment at BKI. The Nobel Prize in Physiology or Medicine was awarded to James P. Allison from the [...]

Published
2018

15. Jounce Therapeutics Founder Dr. James P. Allison Jointly Awarded 2018 Nobel Prize in Physiology or Medicine for the Discovery of Cancer Therapy by Inhibition of Negative Immune Regulation

Subjects
Cancer treatment -- Physiological aspects -- Health aspects, Cancer -- Physiological aspects -- Health aspects, Cancer prevention -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Antineoplastic agents -- Physiological aspects -- Health aspects, Nobel laureates -- Physiological aspects -- Health aspects, General interest, News, opinion and commentary
Abstract

Massachusetts: Jounce Therapeutics, Inc. has issued the following press release: Jounce Therapeutics, Inc. (NASDAQ: JNCE), a clinical-stage company focused on the discovery and development of novel cancer immunotherapies and predictive [...]

Published
2018

16. Jounce Therapeutics Founder Dr. James P. Allison Jointly Awarded 2018 Nobel Prize in Physiology or Medicine for the Discovery of Cancer Therapy by Inhibition of Negative Immune Regulation

Subjects
Cancer treatment -- Physiological aspects -- Health aspects, Cancer -- Physiological aspects -- Health aspects, Cancer prevention -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Antineoplastic agents -- Physiological aspects -- Health aspects, Nobel laureates -- Physiological aspects -- Health aspects, Banking, finance and accounting industries, Business
Abstract

CAMBRIDGE, Mass., Oct 01, 2018 (GLOBE NEWSWIRE via COMTEX) -- Jounce Therapeutics, Inc. (NASDAQ: JNCE), a clinical-stage company focused on the discovery and development of novel cancer immunotherapies and predictive [...]

Published
2018

17. Findings from National Cancer Institute in the Area of Cancer Reported (The Promise and Peril of Targeting Cell Metabolism for Cancer Therapy)

Subjects
United States. National Cancer Institute, Cancer treatment -- Physiological aspects -- Health aspects, Cancer -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Antineoplastic agents -- Physiological aspects -- Health aspects, Cancer research, Tumors, Editors, Health
Abstract

2019 DEC 18 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators discuss new findings in Cancer. According to news reporting originating in Frederick, Maryland, by [...]

Published
2019

18. Findings from University of Shandong in Glioblastomas Provides New Insights (Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma)

Subjects
Efavirenz -- Research -- Physiological aspects -- Health aspects, Cytochrome P-450 -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Cholesterol -- Physiological aspects -- Health aspects, Glioblastomas -- Development and progression -- Research -- Physiological aspects -- Health aspects, Cancer research, Gliomas, Anopheles, Homeostasis, Genetic research, Genes, Editors, Enzymes, Health
Abstract

2019 DEC 11 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators publish new report on Oncology - Glioblastomas. According to news reporting originating in Jinan, [...]

Published
2019

19. New Findings from NOVA Medical School in the Area of Rheumatoid Arthritis Reported (Changes in Iron Metabolism Induced by Anti-Interleukin-6 Receptor Monoclonal Antibody are Associated with an Increased Risk of Infection)

Subjects
Interleukins -- Physiological aspects -- Health aspects, Rheumatoid factor -- Physiological aspects -- Health aspects, Tocilizumab -- Research -- Physiological aspects -- Health aspects, Monoclonal antibodies -- Research -- Physiological aspects -- Health aspects, Medical research -- Physiological aspects -- Health aspects, Infection -- Care and treatment -- Risk factors -- Research -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Arthritis -- Care and treatment -- Risk factors -- Research -- Physiological aspects -- Health aspects, Antibodies, Antiarthritic agents, Autoimmune diseases, Editors, Health
Abstract

2019 JUL 17 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators discuss new findings in Autoimmune Diseases and Conditions - Rheumatoid Arthritis. According to news [...]

Published
2019

20. Study Results from Andong National University in the Area of Photorhabdus Reported (Eicosanoid mediation of immune responses at early bacterial infection stage and its inhibition by Photorhabdus temperata subsp. temperata, an entomopathogenic ...)

Subjects
Bacterial infections -- Research -- Physiological aspects -- Health aspects, Mediation -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Immune response -- Physiological aspects -- Health aspects, Biological sciences, Health
Abstract

2018 SEP 4 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Gram-Negative Bacteria - Photorhabdus. According to news reporting from [...]

Published
2018

21. Findings from Imperial College Has Provided New Data on Autoimmune Diseases and Conditions [C1q restrains autoimmunity and viral infection by regulating CD8(+) T cell metabolism]

Subjects
Lupus -- Research -- Physiological aspects -- Health aspects, Systemic lupus erythematosus -- Research -- Physiological aspects -- Health aspects, Autoimmunity -- Physiological aspects -- Health aspects, Medical research -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, T cells -- Physiological aspects -- Health aspects, Health, University of London. Imperial College of Science and Technology
Abstract

2018 MAY 30 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators publish new report on Immune System Diseases and Conditions - Autoimmune Diseases and Conditions. [...]

Published
2018

22. Researchers at Albert Einstein College of Medicine receive $2.6 million NIH grant to develop targeted cancer immunotherapies

Subjects
United States. National Institutes of Health -- Government finance, Cancer vaccines -- Physiological aspects -- Health aspects, Cancer -- Drug therapy -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Multiple sclerosis -- Drug therapy -- Physiological aspects -- Health aspects, Pharmaceuticals and cosmetics industries, Health, Science and technology, Yeshiva University. Albert Einstein College of Medicine
Abstract

2016 OCT 31 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Vaccine Week -- (BRONX, NY)--The National Institutes of Health has awarded two co-investigators at Albert Einstein College [...]

Published
2016

23. Findings on Immunotherapy Discussed by Investigators at Washington University (Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer)

Subjects
Vaccines -- Research -- Physiological aspects -- Health aspects, Inflammation -- Research -- Care and treatment -- Physiological aspects -- Health aspects, Tryptophan -- Research -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Colorectal cancer -- Research -- Care and treatment -- Physiological aspects -- Health aspects, Pharmaceuticals and cosmetics industries, Health, Science and technology, Washington University
Abstract

2016 FEB 1 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Vaccine Week -- Data detailed on Biotechnology have been presented. According to news reporting originating in St. [...]

Published
2016

24. Effects of G418 on Thymidine Kinase/Neomycine Resistance Transduced T Lymphocytes

Subjects
Transplantation of organs, tissues, etc. -- Physiological aspects -- Health aspects, Oncology, Experimental -- Health aspects -- Physiological aspects, T cells -- Health aspects -- Physiological aspects, Biological products -- Physiological aspects -- Health aspects, Bone marrow -- Transplantation, Gene therapy -- Physiological aspects -- Health aspects, Immunotherapy -- Physiological aspects -- Health aspects, Transduction -- Health aspects -- Physiological aspects, Protein kinases -- Health aspects -- Physiological aspects, Graft versus host reaction -- Physiological aspects -- Health aspects, Cancer -- Research, Health, Physiological aspects, Health aspects
Abstract

M. Di Ianni, F. Lucheroni, A. Terenzi, K. Perruccio, S. Di Florio, M.F. Martelli and A. Tabilio. Hematology and Clinical Immunology Section, Department of Clinical Medicine, Pathology and Pharmacology, Perugia [...]

Published
1998

25. Cancer Vaccines Plasmid DNA/Lipid Complexes Are Effective Vehicles for Autologous Vaccine

Subjects
Immunotherapy -- Physiological aspects -- Health aspects, Plasmids -- Health aspects -- Physiological aspects, Cancer vaccines -- Physiological aspects -- Health aspects, Health, Physiological aspects, Health aspects
Abstract

Successful transfection of fresh or short-term cultured primary tumor cells with plasmid DNA/lipid complexes suggests a clinically feasible approach to a safe cancer vaccine. Tumor vaccination protocols designed around unmodified [...]

Published
1998

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