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Your search keyword '"Immunotherapy -- Personal narratives"' showing total 16 results
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16 results on '"Immunotherapy -- Personal narratives"'

1. I had 'inoperable' bowel cancer - a year later I was given the all-clear. Martyn Edwards shares how a regime of chemo, an immune-boosting diet and positivity helped him beat the disease

Subjects
Diseases -- Personal narratives, Colorectal cancer -- Personal narratives, Immunotherapy -- Personal narratives, Chemotherapy -- Personal narratives, Cancer -- Chemotherapy, General interest
Abstract

Byline: Martyn Edwards My first meeting with the oncologist was the worst. I recall him saying: 'You need to prepare yourself that this may not be a positive outcome. The [...]

Published
2024

2. 'I drank the same shot everyday for a week and the results were a huge surprise'; Ginger shots have been a go-to for many people for years, but I never really understood the hype until I tried them for myself -and the results were surprising

Subjects
Immunotherapy -- Personal narratives, General interest, News, opinion and commentary
Abstract

Byline: By, Diana Buntajova & Rom Preston-Ellis My mate has been raving about the benefits of ginger shots for boosting immunity for years, writes Diana Buntajova from the Express. She [...]

Published
2024

3. 'Pride of Britain award changed my life -it's hard to believe I'm the same person'; Mirror writer Cecilia Adamou received a Teenager of Courage award in 2014 after recovering from a six-month regime of treatment for cancer -which included radiotherapy, immunotherapy and brain surgery

Subjects
Immunotherapy -- Personal narratives, Cancer -- Care and treatment -- Personal narratives, Teenagers -- Achievements and awards, Youth -- Achievements and awards, Radiotherapy -- Personal narratives, Surgery -- Personal narratives, General interest, News, opinion and commentary
Abstract

Byline: By, Cecilia Adamou I received a Pride of Britain for Teenager of Courage in 2014 and when I was asked to return to work at the awards eight years [...]

Published
2024

4. Mosley's clever health tweaks put me on a changed path

Subjects
Personal narratives, Immunotherapy -- Personal narratives
Abstract

I often think of Michael Mosley when I'm taking a shower. Let me hastily add that it's because I can hear his voice in my head with its distinctive delivery, [...]

Published
2024

5. I-Mab Reports 1H 2024 Financial Results, Pipeline Progress, and Business Updates

Subjects
Pipe lines -- Personal narratives, Immunotherapy -- Personal narratives, General interest, News, opinion and commentary
Abstract

ROCKVILLE: I-Mab Biopharma has issued the following news release: I-Mab (NASDAQ: IMAB) (the 'Company'), a U.S.-based, global biotech company, exclusively focused on the development of highly differentiated immunotherapies for the [...]

Published
2024

6. I'm 46 and my cancer treatment hasn't worked -- but I'm still not afraid of death; I had hoped I would be afforded some extra time by immunotherapy -- instead, I am setting out a few final thoughts

Subjects
Immunotherapy -- Personal narratives, Cancer -- Care and treatment, General interest, News, opinion and commentary
Abstract

Byline: Simon Boas We interviewed cancer-sufferer Simon Boas last month after the letter he wrote -- ' A Beginner's Guide to Dying ' -- inspired thousands In February, I wrote [...]

Published
2024

7. Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy

Author

Such, Lina, Zhao, Fang, Liu, Derek, Thier, Beatrice, Le-Trilling, Vu Thuy Khanh, Sucker, Antje, Coch, Christoph, Pieper, Natalia, Howe, Sebastian, Bhat, Hilal, Kalkavan, Halime, Ritter, Cathrin, Brinkhaus, Robin, Ugurel, Selma, Koster, Johannes, Seifert, Ulrike, Dittmer, Ulf, Schuler, Martin, Lang, Karl S., Kufer, Thomas A., Hartmann, Gunther, Becker, Jurgen C., Horn, Susanne, Ferrone, Soldano, Liu, David, Van Allen, Eliezer M., Schadendorf, Dirk, Griewank, Klaus, Trilling, Mirko, and Paschen, Annette

Subjects
Bristol-Myers Squibb Co., Novartis AG, Development and progression, Personal narratives, Antigens -- Personal narratives, Biological response modifiers -- Personal narratives, Medical research -- Personal narratives, Immunotherapy -- Personal narratives, Interferon -- Personal narratives, Melanoma -- Development and progression, RNA -- Personal narratives, T cells -- Personal narratives
Abstract

Introduction Cytotoxic [CD8.sup.+] T cells are critical mediators of clinical responses in tumor immunotherapy, killing cancer cells upon recognition of HLA class I (HLA-I) tumor antigen peptide complexes. Antigen processing [...], Understanding tumor resistance to T cell immunotherapies is critical to improve patient outcomes. Our study revealed a role for transcriptional suppression of the tumor-intrinsic HLA class I (HLA-I) antigen processing and presentation machinery (APM) in therapy resistance. Low HLA-I APM mRNA levels in melanoma metastases before immune checkpoint blockade (ICB) correlated with nonresponsiveness to therapy and poor clinical outcome. Patient-derived melanoma cells with silenced HLA-I APM escaped recognition by autologous [CD8.sup.+] T cells. However, targeted activation of the innate immunoreceptor RIG-I initiated de novo HLA-I APM transcription, thereby overcoming T cell resistance. Antigen presentation was restored in interferon-sensitive (IFN-sensitive) but also immunoedited IFN-resistant melanoma models through RIG-I-dependent stimulation of an IFN-independent salvage pathway involving IRF1 and IRF3. Likewise, enhanced HLA-I APM expression was detected in RIG-[I.sup.hi] ([DDX58.sup.hi]) melanoma biopsies, correlating with improved patient survival. Induction of HLA-I APM by RIG-I synergized with antibodies blocking PD-1 and TIGIT inhibitory checkpoints in boosting the antitumor T cell activity of ICB nonresponders. Overall, the herein-identified IFN-independent effect of RIG-I on tumor antigen presentation and T cell recognition proposes innate immunoreceptor targeting as a strategy to overcome intrinsic T cell resistance of IFN-sensitive and IFN-resistant melanomas and improve clinical outcomes in immunotherapy.

Published
2020
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8. Julia Bradbury reveals the great outdoors helped her get through cancer diagnosis; I love nothing more than taking my three children on our own adventures. Getting outside has so many proven benefits -- boosting immunity, elevating mood, increasing creativity and productivity, and even dampening anxiety

Subjects
Cancer -- Diagnosis, Immunotherapy -- Personal narratives, Creative ability -- Personal narratives, General interest, News, opinion and commentary
Abstract

Byline: By, Julia Bradbury I can't remember a time I didn't enjoy getting outdoors and experiencing all that the natural world has to offer. Growing up, my dad Michael would [...]

Published
2023

9. Julia Bradbury reveals the great outdoors helped her get through cancer diagnosis; I love nothing more than taking my three children on our own adventures. Getting outside has so many proven benefits -- boosting immunity, elevating mood, increasing creativity and productivity, and even dampening anxiety

Subjects
Cancer -- Diagnosis, Immunotherapy -- Personal narratives, Creative ability -- Personal narratives, General interest, News, opinion and commentary
Abstract

Byline: By, Chloe Robinson I can't remember a time I didn't enjoy getting outdoors and experiencing all that the natural world has to offer. Growing up, my dad Michael would [...]

Published
2023

13. Type I interferon modulates Langerhans cell ADAM17 to promote photosensitivity in lupus

Subjects
Personal narratives, Lupus -- Personal narratives, Biological response modifiers -- Personal narratives, Immunotherapy -- Personal narratives, Skin -- Personal narratives, Interferon -- Personal narratives, Drug approval -- Personal narratives
Abstract

2021 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- According to news reporting based on a preprint abstract, our journalists obtained the following quote [...]

Published
2021

14. Mary Elizabeth Williams: 'A Series Of Catastrophes And Miracles'

Subjects
A Series of Catastrophes and Miracles (Autobiography), Personal narratives, Writers -- Interviews, Immunotherapy -- Personal narratives, Melanoma -- Personal narratives
Abstract

Immunotherapy has been billed as the most significant advancement in cancer treatment in generations. Six years ago few had ever heard of it. One woman's story on how she became [...]

Published
2016

16. My quest for the Last Flu Jab in Britain Are the so-called worried well really to blame for the sudden shortage of vaccine? The very idea brings hypochondriac JOHN O'CONNELL out in blotches

Author

O'Connell, John

Subjects
Immunotherapy -- Personal narratives, Influenza -- Personal narratives, General interest, News, opinion and commentary
Abstract

It took 20 minutes of frantic phoning around before I heard the magic word: 'yes''. I slammed down the receiver, raced out of the office and jumped into a taxi. [...]

Published
2005

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