1. Immune Checkpoint Inhibitor-Induced Primary Adrenal Insufficiency: A Case Report
- Author
-
Gupta, Rahul and Lubkin, Cary
- Subjects
Immunotherapy ,shock ,adrenal insufficiency ,immune checkpoint inhibitor ,case report - Abstract
Introduction: One of the less common and more life-threatening etiologies of adrenal insufficiency is immune checkpoint inhibitor (ICI)-induced primary adrenal insufficiency (PAI). Patients typically present with fatigue, malaise, and nausea and are treated empirically with hydrocortisone. Case Report: We present the case of a 59-year-old female who presented with hypotension, which initially was thought to be due to hypovolemia or medication-related, but was ultimately found to have PAI. Conclusion: This case highlights the importance of early detection of ICI-induced primary adrenal insufficiency, given its associated morbidity and mortality and its incidence in patients with a history of immunotherapy.
- Published
- 2024