1. Clinical Utility of Serum Cystatin C in Predicting Coronary Artery Disease in Patients Without Chronic Kidney Disease
- Author
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Imen Gammoudi, A. Dandana, Abdelhedi Miled, Salima Ferchichi, H. Chahed, Faouzi Addad, and Abdelkader Chalghoum
- Subjects
Microbiology (medical) ,medicine.medical_specialty ,Homocysteine ,Clinical Biochemistry ,Renal function ,urologic and male genital diseases ,medicine.disease_cause ,Gastroenterology ,Coronary artery disease ,chemistry.chemical_compound ,Internal medicine ,Immunology and Allergy ,Medicine ,biology ,business.industry ,Biochemistry (medical) ,Public Health, Environmental and Occupational Health ,Hematology ,medicine.disease ,female genital diseases and pregnancy complications ,Medical Laboratory Technology ,medicine.anatomical_structure ,chemistry ,Cystatin C ,biology.protein ,Cardiology ,Cystatin ,business ,Oxidative stress ,Kidney disease ,Artery - Abstract
Background Cystatin C has been proposed as a novel marker of renal function and predictor of cardiovascular risk. The aim of this study was to investigate the role of cystatin C level as a predictor of cardiovascular events in patients with coronary artery disease (CAD). Methods Three hundred and five coronary artery patients were included in this study. Serum cystatin C levels, high-sensitive C-reactive protein (hs-CRP), and oxidative stress were measured. Estimated glomerular filtration rate (eGFR) and the CAD severity score were calculated. Results Cystatin C was correlated with the CAD severity score (r = 0.631, P 50. Every 0.1 mg/l increase in cystatin C, 2 mg/l increase in hs-CRP, 0.2 mmol/l decrease in high-density lipoprotein cholesterol, 13.7 ml/min decrease in eGFR, and 1.51 μmol/l increase in homocysteine caused a 34, 12, 5, and 22% increase in the risk of having CAD, respectively. Conclusion Cystatin C could be a useful laboratory biochemical marker in predicting the severity of CAD. Cystatin C is associated with biochemical atherosclerosis markers such as CRP and homocysteine.
- Published
- 2014