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1. Correlation of nailfold capillaroscopy findings with history of digital ulcer on same finger: Results of SCLEROCAP study

Author

Boulon, Carine, Velardo, Fanny, Blaise, Sophie, Mangin, Marion, Chevoir, Joelle Decamps-Le, Senet, Patricia, Lazareth, Isabelle, Baudot, Nathalie, Tribout, Laurent, Imbert, Bernard, Lapebie, François-Xavier, Dari, Loubna, Lacroix, Philippe, Truchetet, Marie-Elise, Seneschal, Julien, Solanilla, Anne, Lazaro, Estibaliz, Quéré, Isabelle, Pistorius, Marc-Antoine, Asselineau, Julien, Lhomme, Edouard, Carpentier, Patrick, and Constans, Joël

Published
2022
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2. Rivaroxaban vs Dalteparin in Cancer-Associated Thromboembolism: A Randomized Trial

Author

Meyer, Guy, Mismetti, Patrick, Chatellier, Gilles, Laporte, Silvy, Decousus, Hervé, Mahé, Isabelle, Falvo, Nicolas, Delluc, Aurélien, Bertoletti, Laurent, Laneau, Christine, Dinut, Aurelia, Aegerter, Philippe, Emmerich, Joseph, Girard, Philippe, Messas, Emmanuel, Revel, Marie-Pierre, Charles-Nelson, Anaïs, Acassat, Sandrine, Grange, Claire, Planquette, Benjamin, Sanchez, Olivier, Plaisance, Ludovic, Poénou, Géraldine, Pernod, Gilles, Imbert, Bernard, Zenati, Nora, Couturaud, Francis, Le Moigne, Emmanuelle, Le Mao, Raphael, Hoffmann, Clément, Elias, Antoine, Elias, Marie, Loffroy, Romaric, Jandot, Maud, Sevestre, Marie-Antoinette, Modéliar Rémond, Santhi Samy, Ray, Valérie, Burnod, Alexis, Roy, Pierre-Marie, Moumneh, Thomas, Henni, Samir, Brebion, Nicolas, Timor-David, Miruna, Constans, Joël, Boulon, Carine, Aquilanti, Sandro, Brisot, Dominique, Bura-Rivière, Alessandra, Sevestre, Marie Antoinette, Timar-David, Miruna, and Constans, Joel

Published
2022
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3. Nailfold dermoscopy predicts the absence of a capillaroscopy sclerodermic pattern: The multicentre, prospective VASCUL‐R trial.

Author

Monfort, Jean‐Benoît, Klejtman, Tiffany, Lazareth, Isabelle, Kottler, Diane, Blaise, Sophie, Imbert, Bernard, Chaby, Guillaume, Lok, Catherine, Maillard, Hervé, Beneton, Nathalie, Journet‐Tollhupp, Julie, Goujon, Elisa, Jacquin, Aurélien, Tella, Emilie, Mboup, Bassirou, Vicaut, Eric, and Senet, Patricia

Subjects
RAYNAUD'S disease, DERMOSCOPY, CAPILLAROSCOPY, DERMATOLOGISTS, HEMORRHAGE, CAPILLARIES
Abstract

Background: Nailfold capillaroscopy is recommended to diagnose primary or secondary Raynaud's phenomenon (RP). Capillaroscopy is normal in primary RP, which is the most frequent. Screening for RP capillary anomalies with nailfold dermoscopy has been promising. Objective: To determine whether normal nailfold dermoscopy—based on the absence of five criteria that define a sclerodermic pattern—is able to predict normal capillaroscopy with good positive‐predictive value (PPV). Methods: Prospective, 2‐phase (monocentre and multicentre) study on patients at first consultation for RP undergoing nailfold video capillaroscopy (NVC) and nailfold dermoscopy by two different 'blinded' trained observers, respectively, a vascular specialist and a dermatologist, not familiar with capillaroscopy. The five criteria noted were as follows: disorganization, megacapillaries, low capillary density, avascular areas and haemorrhages. Results: Based on 105 patients, the dermoscopy PPV for a normal NVC was 100% (p = 0.015), with 37.9% sensitivity, when no criterion was observed. Excluding haemorrhages, the PPV remained 100% (p < 0.0001), with sensitivity rising to 73.7% and 100% specificity. Conclusions: Normal nailfold dermoscopy with the absence of four easy‐to‐observe criteria predicts normal NVC with an excellent PPV. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Une dermoscopie périunguéale normale prédit l’absence de paysage sclérodermique en capillaroscopie

Author

Monfort, Jean-Benoît, primary, Klejtman, Tiffany, additional, Vicaut, Eric, additional, Lazareth, Isabelle, additional, Kottler, Diane, additional, Blaise, Sophie, additional, Imbert, Bernard, additional, Chaby, Guillaume, additional, Lok, Catherine, additional, Maillard, Hervé, additional, Beneton, Nathalie, additional, Journet, Julie, additional, Goujon, Elisa, additional, Jacquin, Aurélien, additional, Tella, Emilie, additional, and Senet, Patricia, additional

Published
2023
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12. Reproducibility of capillaroscopic classifications of systemic sclerosis: results from the SCLEROCAP study

Author

Boulon, Carine, Devos, Sophie, Mangin, Marion, Decamps-Le Chevoir, Joelle, Senet, Patricia, Lazareth, Isabelle, Baudot, Nathalie, Tribout, Laurent, Imbert, Bernard, Blaise, Sophie, Sintes, Pierre, Lapebie, François-Xavier, Lacroix, Philippe, Truchetet, Marie-Elise, Seneschal, Julien, Solanilla, Anne, Skopinski, Sophie, Lazaro, Estibaliz, Quéré, Isabelle, Pistorius, Marc-Antoine, Le Hello, Claire, Perez, Paul, Carpentier, Patrick, and Constans, Joël

Published
2017
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13. Rivaroxaban vs Dalteparin in Cancer-Associated Thromboembolism

Author

Planquette, Benjamin, primary, Bertoletti, Laurent, additional, Charles-Nelson, Anaïs, additional, Laporte, Silvy, additional, Grange, Claire, additional, Mahé, Isabelle, additional, Pernod, Gilles, additional, Elias, Antoine, additional, Couturaud, Francis, additional, Falvo, Nicolas, additional, Sevestre, Marie Antoinette, additional, Ray, Valérie, additional, Burnod, Alexis, additional, Brebion, Nicolas, additional, Roy, Pierre-Marie, additional, Timar-David, Miruna, additional, Aquilanti, Sandro, additional, Constans, Joel, additional, Bura-Rivière, Alessandra, additional, Brisot, Dominique, additional, Chatellier, Gilles, additional, Sanchez, Olivier, additional, Meyer, Guy, additional, Girard, Philippe, additional, Mismetti, Patrick, additional, Decousus, Hervé, additional, Delluc, Aurélien, additional, Laneau, Christine, additional, Dinut, Aurelia, additional, Aegerter, Philippe, additional, Emmerich, Joseph, additional, Messas, Emmanuel, additional, Revel, Marie-Pierre, additional, Acassat, Sandrine, additional, Planquette, Benjamin, additional, Plaisance, Ludovic, additional, Poénou, Géraldine, additional, Imbert, Bernard, additional, Zenati, Nora, additional, Le Moigne, Emmanuelle, additional, Le Mao, Raphael, additional, Hoffmann, Clément, additional, Elias, Marie, additional, Loffroy, Romaric, additional, Jandot, Maud, additional, Sevestre, Marie-Antoinette, additional, Modéliar Rémond, Santhi Samy, additional, Moumneh, Thomas, additional, Henni, Samir, additional, Timor-David, Miruna, additional, Constans, Joël, additional, and Boulon, Carine, additional

Published
2022
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14. Correlation of Nailfold Capillaroscopy Findings with History of Digital Ulcer on Same Finger: Results of SCLEROCAP Study

Author

Boulon, Carine, primary, Velrado, Fanny, additional, Blaise, Sophie, additional, Mangin, Marion, additional, Le Chevoir, Joelle Decamps, additional, Senet, Patricia, additional, Lazareth, Isabelle, additional, Baudot, Nathalie, additional, Tribout, Laurent, additional, Imbert, Bernard, additional, Lapebie, François-Xavier, additional, Dari, Loubna, additional, Lacroix, Philippe, additional, Truchetet, Marie-Elise, additional, Seneschal, Julien, additional, Solanilla, Anne, additional, Lazaro, Estibaliz, additional, Quéré, Isabelle, additional, Pistorius, Marc-Antoine, additional, Asselineau, Julien, additional, Lhomme, Edouard, additional, Carpentier, Patrick, additional, and constans, joel, additional

Published
2022
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15. Long-Term Outcomes Among Participants in the WEGENT Trial of Remission-Maintenance Therapy for Granulomatosis With Polyangiitis (Wegenerʼs) or Microscopic Polyangiitis

Author

Puéchal, Xavier, Pagnoux, Christian, Perrodeau, Élodie, Hamidou, Mohamed, Boffa, Jean-Jacques, Kyndt, Xavier, Lifermann, François, Papo, Thomas, Merrien, Dominique, Smail, Amar, Delaval, Philippe, Hanrotel-Saliou, Catherine, Imbert, Bernard, Khouatra, Chahéra, Lambert, Marc, Leské, Charles, Ly, Kim H., Pertuiset, Edouard, Roblot, Pascal, Ruivard, Marc, Subra, Jean-François, Viallard, Jean-François, Terrier, Benjamin, Cohen, Pascal, Mouthon, Luc, Le Jeunne, Claire, Ravaud, Philippe, Guillevin, Loïc, Rispal, P., Baidi, N., Chrétien, O., Cevallos, R., Ducroix, J.-P., Darmaillacq, J.-G., Dubas, F., Maghakian, M.-N., Moreau, C., Dubos-Arvis, C., Frognier, R., Gobert, P., Pollini, J., Pingat, D., Janin-Manificat, L., Lafon, B., Kettaneh, A., Moiton, M., Ragnaud, J. M., Boudray, C., Raphanel, B., Renand, J.-P., Roux, M., Bonnaire, G., Guiso, A., André, J. M., Perrichot, R., Louvet, J., Artigues, N., Bienvenu, B., de Ligny, Hurault B., Le Hello, C., Letellier, P., Lobbedez, T., Ollivier, Y., Pujo, M., Ryckelynck, J.-P., Montseny, J.-J., Collet, P., Ayach, B., Dion, J.-J., Mouawad, H., Damade, R., Dupouët, L., Asgaraly, K., Depernet, B., Colin, T., Ioos, V., Rieu, V., Belmatoug, N., Foulon, L., Jebrak, G., du Coedic, L., Bachmeyer, C., Dumoulin, A., Godeau, B., Khellaf, M., Michel, M., Pastural, M., Schaeffer, A., Geffroy, M., Bielefeld, P., Fichet, D., Saraux, J.-L., Vinzio, S., Ehrlacher, P., Azria, A., Mariette, X., Tiab, M., Delansorne, D., Boullanger, N., Closs-Prophette, F., Goldstein, A., Bouscaud, L., Meunier, V., Hachulla, E., Hatron, P.-Y., Launay, D., Hottelart, C., Liozon, E., Longuet, O., Loustaud-Ratti, V., Soria, P., Vidal, E., Geffray, L., Henri, P., Landru, I., Guillemot, J.-M., Le Noach, J., Cordier, J.-F., Cottin, V., Gentil, B., Demolombe-Rague, S., Girard-Madoux, M.-H., Ninet, J., Pinède, L., Meynieux, J.-P., Serratrice, J., Xeridat, B., Bagnères, D., Roudier, J., Denis, B., Boillet, N., Geraads, A., Teyssandier, R., Degraeve, F., Le Quellec, A., Rivière, S., Rogé, C., Fauchay, J.-P., Wahl, D., Agard, C., Généreau, T., Meker, D., Bensakel, S., Vecina, F., Aubier, M., Foulon, G., Lelièvre, P., Lidove, O., Mignon, F., Meyer, O., Piperaud, M., Queffeulou, G., Vrtovsnik, F., Aouba, A., Arène, J.-P., Bérezné, A., Le Guern, V., Amoura, Z., Benveniste, O., Dimitri, D., Huong, Lê Thi D., Bergeron, A., Bourgarit, A., Farge, D., Mahr, A., Martinez, F., Séréni, D., Aslangul, E., Arnal, C., Cadranel, J., Daugas, E., Pelle, G., Rossert, J., Wislez, M., Gayraud, M., Bruet, A., Hillion, Y., Paccalin, M., Léone, J., Pennaforte, J.-L., Barbier, S., Legallicier, B., Dominique, S., Charasse, C., Coëtmeur, D., Duhamel, E., Goulias, J.-P., Bournerias, F., Gautherie, P., Schlienger, J.-L., Vidal, A., Diot, E., Diot, P., Vanhille, P., Bindi, P., and Cervantes, G.

Published
2016
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16. French recommendations for the management of systemic sclerosis

Author

Hachulla, Eric, Agard, Christian, Allanore, Yannick, Avouac, Jérôme, Bader-Meunier, Brigitte, Belot, Alexandre, Berezne, Alice, Bouthors, Anne-Sophie, Condette-Wojtasik, Geraldine, Constans, Joël, de Groote, Pascal, Diot, Elisabeth, Dumas, Florence, Jego, Patrick, Joly, Francisca, Launay, David, Le Guern, Veronique, Le Quintrec, Janine-Sophie, Lescaille, Géraldine, Meune, Christophe, Moulin, Bruno, Nguyen, Christelle, Omeish, Nadine, Pene, Frédéric, Richard, Marie-Aleth, Rochefort, Juliette, Roren, Alexandra, Sitbon, Olivier, Sobanski, Vincent, Truchetet, Marie-Elise, Mouthon, Luc, Bayen, Marc, Bergot, Emmanuel, Berthier, Sabine, Bosco, Julia, Bouhnik, Yoram, Chaigne, Benjamin, Cottin, Vincent, Crestani, Bruno, Deligny, Christophe, Descroix, Vianney, Farge, Dominique, Godard, Dominique, Granel, Brigitte, Guilpain, Philippe, Imbert, Bernard, Le Quellec, Alain, Lega, Christophe, Lok, Catherine, Maillard, Hélène, Martin, Thierry, Pugnet, Grégory, Queyrel, Viviane, Raffray, Loïc, Rilliard, Frédéric, Romier, Mélanie, Schuller, Laurence, Servettaz, Amélie, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Bordeaux [Bordeaux], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Pontchaillou [Rennes], Hôpital Beaujon [AP-HP], Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service de médecine interne et centre de référence des maladies rares [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Avicenne [AP-HP], CHU Strasbourg, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)

Subjects
medicine.medical_specialty, Poor prognosis, Hypertension, Pulmonary, Scleroderma Renal Crisis, Aucun, Connective tissue, MESH: Skin Diseases, Favorable prognosis, Recommendations, Skin Diseases, Scleroderma, MESH: Scleroderma, Systemic, 03 medical and health sciences, 0302 clinical medicine, MESH: Skin, Fibrosis, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Generalized Disease, Position Statement, skin and connective tissue diseases, Genetics (clinical), Skin, 030203 arthritis & rheumatology, Scleroderma, Systemic, MESH: Humans, integumentary system, MESH: Hypertension, Pulmonary, business.industry, Interstitial lung disease, General Medicine, medicine.disease, Dermatology, Treatment, medicine.anatomical_structure, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Medicine, Systemic sclerosis, business, Lung Diseases, Interstitial, MESH: Lung Diseases, Interstitial
Abstract

Systemic sclerosis (SSc) is a generalized disease of the connective tissue, arterioles, and microvessels, characterized by the appearance of fibrosis and vascular obliteration. There are two main phenotypical forms of SSc: a diffuse cutaneous form that extends towards the proximal region of the limbs and/or torso, and a limited cutaneous form where the cutaneous sclerosis only affects the extremities of the limbs (without passing beyond the elbows and knees). There also exists in less than 10% of cases forms that never involve the skin. This is called SSc sine scleroderma. The prognosis depends essentially on the occurrence of visceral damage and more particularly interstitial lung disease (which is sometimes severe), pulmonary arterial hypertension, or primary cardiac damage, which represent the three commonest causes of mortality in SSc. Another type of involvement with poor prognosis, scleroderma renal crisis, is rare (less than 5% of cases). Cutaneous extension is also an important parameter, with the diffuse cutaneous forms having less favorable prognosis.

Published
2021

17. Reporting items for capillaroscopy in clinical research on musculoskeletal diseases: A systematic review and international Delphi consensus

Author

Søren Jacobsen, Miguel Antonio Mesa Navas, Oliver Distler, Josephine Vila, Alicia M. Hinze, Codrina Ancuta, Alexandre E. Voskuyl, Emmanuel Chatelus, Sophie Blaise, Antonia Valenzuela, Roger Hesselstrand, Madelon C. Vonk, Francesca Ingegnoli, Roberto Caporali, Kaushik Bhojani, Gabriela Hernández-Molina, Jeska K de Vries-Bouwstra, Tommaso Schioppo, Yimy F. Medina, Nicola Ughi, Carlos Jaime Velásquez-Franco, Murat Inanc, Carina Mihai, Jean Luc Senécal, Verônica Silva Vilela, John D Pauling, Peter A. Merkel, Ayyappa Duba, Wendy Stevens, Marina Scolnik, Thierry Martin, Saeedeh Shenavandeh, Antonella Riccardi, Michael R. Hughes, Francesca Bartoli, Yolanda Braun Moscovici, Imbert Bernard, Mojgan Sarafrazi, Jean-Luc Cracowski, Rosaria Irace, Valeria Riccieri, Jan T. M. Lenaerts, Ashima Makol, Maurizio Cutolo, Martial Koenig, Vivien Hsu, Mohammed Akil, Maria Martin Lopez, Eleftherios Pelechas, Walter Alberto Sifuentes-Giraldo, Andreu Fernández-Codina, Rossella De Angelis, Geneviève Gyger, Sevdalina Nikolova Lambova, Valentina Messiniti, Ivan Foeldvari, Lidia Rudnicka, Carmen Pizzorni, Julia Spierings, Ariane L. Herrick, Tracy M. Frech, Oleg Nadashkevich, Colin Baines, Cho Mar Lwin, Dieneke Schonenberg-Meinema, Mary Ellen Csuka, Chris T. Derk, Alberto Sulli, Serena Guiducci, Doron Rimar, Mirtha Sabelli, Miguel Pedro Guerra, Vanessa Smith, Soumya Chatterjee, Sonali Narain, Rheumatology, AII - Inflammatory diseases, Graduate School, and Paediatric Infectious Diseases / Rheumatology / Immunology

Subjects
medicine.medical_specialty, Delphi Technique, Delphi method, Nailfold videocapillaroscopy, nailfold capillaroscopy, Microscopic Angioscopy, Rheumatology, Medicine, Humans, Pharmacology (medical), computer.programming_language, Nailfold Capillaroscopy, business.industry, Checklist, Clinical trial, Clinical research, musculoskeletal diseases, connective tissue disease, consensus, Family medicine, Research studies, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], business, computer, Delphi, reporting standard
Abstract

Objectives The level of detail included when describing nailfold videocapillaroscopy (NVC) methods varies among research studies, making interpretation and comparison of results challenging. The overarching objective of the present study was to seek consensus on the reporting standards in NVC methodology for clinical research in rheumatic diseases and to propose a pragmatic reporting checklist. Methods Based on the items derived from a systematic review focused on this topic, a three-step web-based Delphi consensus on minimum reporting standards in NVC was performed among members of the European League against Rheumatism (EULAR) Study Group on Microcirculation in Rheumatic Diseases and the Scleroderma Clinical Trials Consortium. Results A total of 319 articles were selected by the systematic review, and 46 items were proposed in the Delphi process. This Delphi exercise was completed by 80 participants from 31 countries, including Australia and countries within Asia, Europe, North America and South America. Agreement was reached on items covering three main areas: patient preparation before NVC (15 items), device description (5 items) and examination details (13 items). Conclusion Based on the available evidence, the description of NVC methods was highly heterogeneous in the identified studies and differed markedly on several items. A reporting checklist of 33 items, based on practical suggestions made (using a Delphi process) by international participants, has been developed to provide guidance to improve and standardize the NVC methodology to be applied in future clinical research studies.

Published
2021

18. Finger Systolic Blood Pressure Index (FBPI) measurement: a useful tool for the evaluation of arterial disease in patients with systemic sclerosis

Author

Blaise, Sophie, primary, Boulon, Carine, additional, Mangin, Marion, additional, Senet, Patricia, additional, Lazareth, Isabelle, additional, Imbert, Bernard, additional, Lapebie, François‐Xavier, additional, Lacroix, Philippe, additional, Constans, Joël, additional, and Carpentier, Patrick, additional

Published
2020
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19. The three-year incidence of pulmonary arterial hypertension associated with systemic sclerosis in a multicenter nationwide longitudinal study in France

Author

Hachulla, Eric, de Groote, Pascal, Gressin, Virginie, Sibilia, Jean, Diot, Elisabeth, Carpentier, Patrick, Mouthon, Luc, Hatron, Pierre-Yves, Jego, Patrick, Allanore, Yannick, Tiev, Kiet Phong, Agard, Christian, Cosnes, Anne, Cirstea, Daniela, Constans, Joël, Farge, Dominique, Viallard, Jean-François, Harle, Jean-Robert, Patat, Frédéric, Imbert, Bernard, Kahan, André, Cabane, Jean, Clerson, Pierre, Guillevin, Loïc, and Humbert, Marc

Published
2009
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24. On-Demand Sildenafil as a Treatment for Raynaud Phenomenon

Author

Roustit, Matthieu, Giai, Joris, Gaget, Olivier, Khouri, Charles, Mouhib, Myriam, Lotito, Adrien, Blaise, Sophie, Seinturier, Christophe, Subtil, Fabien, Paris, Adeline, Cracowski, Claire, Imbert, Bernard, Carpentier, Patrick, Vohra, Sunita, Cracowski, Jean-Luc, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire [Grenoble] (CHU), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Hospices Civils de Lyon (HCL), Université de Lyon, and University of Alberta

Subjects
[STAT.AP]Statistics [stat]/Applications [stat.AP], [STAT.ME]Statistics [stat]/Methodology [stat.ME], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

26. HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome

Author

Belizna, Cristina, primary, Pregnolato, Francesca, additional, Abad, Sebastien, additional, Alijotas-Reig, Jaume, additional, Amital, Howard, additional, Amoura, Zahir, additional, Andreoli, Laura, additional, Andres, Emmanuel, additional, Aouba, Achile, additional, Apras Bilgen, Sule, additional, Arnaud, Laurent, additional, Bienvenu, Boris, additional, Bitsadze, Viktoria, additional, Blanco, Patrick, additional, Blank, Miri, additional, Borghi, Maria Orietta, additional, Caligaro, Antonia, additional, Candrea, Elisabeta, additional, Canti, Valentina, additional, Chiche, Laurent, additional, Chretien, Jean Marie, additional, Cohen Tervaert, Jan Willem, additional, Damian, Laura, additional, Delross, Teresa, additional, Dernis, Emmanuelle, additional, Devreese, Katrien, additional, Djokovic, Aleksandra, additional, Esteve-Valverde, Enrique, additional, Favaro, Maria, additional, Fassot, Céline, additional, Ferrer-Oliveras, Raquel, additional, Godon, Alban, additional, Hamidou, Mohamed, additional, Hasan, Milena, additional, Henrion, Daniel, additional, Imbert, Bernard, additional, Jeandel, Pierre Yves, additional, Jeannin, Pascale, additional, Jego, Patrick, additional, Jourde-Chiche, Noemie, additional, Khizroeva, Jamilya, additional, Lambotte, Olivier, additional, Landron, Cédric, additional, Latino, Jose Omar, additional, Lazaro, Estibaliz, additional, de Leeuw, Karina, additional, Le Gallou, Thomas, additional, Kiliç, Levent, additional, Limper, Maarten, additional, Loufrani, Laurent, additional, Lubin, Romain, additional, Magy-Bertrand, Nadine, additional, Mahe, Guillaume, additional, Makatsariya, Alexander, additional, Martin, Thierry, additional, Muchardt, Christian, additional, Nagy, Gyorgy, additional, Omarjee, Loukman, additional, Van Paasen, Pieter, additional, Pernod, Gilles, additional, Perrinet, Florence, additional, Pïres Rosa, Gilberto, additional, Pistorius, Marc Antoine, additional, Ruffatti, Amelia, additional, Said, Fatma, additional, Saulnier, Patrick, additional, Sene, Damien, additional, Sentilhes, Loic, additional, Shovman, Ova, additional, Sibilia, Jean, additional, Sinescu, Crina, additional, Stanisavljevic, Natasa, additional, Stojanovich, Ljudmila, additional, Tam, Lai Shan, additional, Tincani, Angela, additional, Tollis, Fréderic, additional, Udry, Sebastian, additional, Ungeheuer, Marie Noelle, additional, Versini, Mathilde, additional, Cervera, Ricard, additional, and Meroni, Pier Luigi, additional

Published
2018
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27. Comment on: Reproducibility of the scleroderma pattern assessed by wide-field capillaroscopy in subjects suffering from Raynaud's phenomenon: reply

Author

Constans, Joël, primary, Blaise, Sophie, additional, Lazareth, Isabelle, additional, Le Hello, Claire, additional, Pistorius, Marc-Antoine, additional, Imbert, Bernard, additional, Mangin, Marion, additional, Sintes, Pierre, additional, Senet, Patricia, additional, Decamps-Le Chevoir, Joelle, additional, Tribout, Laurent, additional, Carpentier, Patrick, additional, and Boulon, Carine, additional

Published
2018
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28. Update of EULAR recommendations for the treatment of systemic sclerosis

Author

UMC Utrecht, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Kowal-Bielecka, Otylia, Fransen, Jaap, Avouac, Jerome, Becker, Mike, Kulak, Agnieszka, Allanore, Yannick, Distler, Oliver, Clements, Philip, Cutolo, Maurizio, Czirjak, Laszlo, Damjanov, Nemanja, del Galdo, Francesco, Denton, Christopher P., Distler, Jörg H W, Foeldvari, Ivan, Figelstone, Kim, Frerix, Marc, Furst, Daniel E., Guiducci, Serena, Hunzelmann, Nicolas, Khanna, Dinesh, Matucci-Cerinic, Marco, Herrick, Ariane L., van den Hoogen, Frank, van Laar, Jacob M., Riemekasten, Gabriela, Silver, Richard, Smith, Vanessa, Sulli, Alberto, Tarner, Ingo, Tyndall, Alan, Welling, Joep, Wigley, Frederic, Valentini, Gabriele, Walker, Ulrich A., Zulian, Francesco, Müller-Ladner, Ulf, Daikeler, Thomas, Lanciano, Elisabetta, Becvár, Radim, Tomcik, Michal, Gindzienska-Sieskiewicz, Ewa, Iudici, Michele, Rednic, Simona, Vlachoyiannopoulos, Panayiotis G., Caporali, Roberto, Carreira, Patricia E., Novak, Srdan, Minier, Tünde, Kucharz, Eugene J., Gabrielli, Armando, Moroncini, Gianluca, Airo, Paolo, Hesselstrand, Roger, Martinovic, Duska, Radic, Mislav, Marasovic-Krstulovic, Daniela, Braun-Moscovici, Yolanda, Monaco, Andrea Lo, Morovic-Vergles, Jadranka, Culo, Melanie I., Henes, Jörg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Michalska-Jakubus, Malgorzata, Seidel, Matthias F., Klinik, Medizinische, Hasler, Paul, Da Silva, José A Pereira, Salvador, Maria J., Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Ananieva, Lidia P., Beretta, Lorenzo, Szucs, Gabriella, Szamosi, Szilvia, de la Puente Bujidos, Carlos, Midtvedt, Øyvind, Hoffmann-Vold, Anna Maria, Launay, David, Hachulla, Eric, Riccieri, Valeria, Ionescu, Ruxandra, Opris, Daniela, Mihai, Carina, Herrgott, Ilka, Beyer, Christian, Ingegnoli, Francesca, von Mühlen, Carlos Alberto, Alegre-Sancho, Juan José, Beltran-Catalan, Emma, Aringer, Martin, Fantana, Julia, Leuchten, Nicolai, Tausche, Anne Kathrin, Langhe, Ellen De, Vanthuyne, Marie, Anic, Branimir, Barešic, Marko, Mayer, Miroslav, üprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Jimenez, Sergio A., Popa, Serghei, Agachi, Svetlana, Zenone, Thierry, Stebbings, Simon, Dockerty, Joanne, Vacca, Alessandra, Schollum, Joanna, Veale, Douglas J., Toloza, Sergio, Xu, Dong, Olas, Jacek, Rosato, Edoardo, Foti, Rosario, Adler, Sabine, Dan, Diana, Wiesik-Szewczyk, Ewa, Olesinska, Marzena, Kayser, Cristiane, Fathi, Nihal, de la Peña Lefebvre, Paloma García, Imbert, Bernard, UMC Utrecht, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Kowal-Bielecka, Otylia, Fransen, Jaap, Avouac, Jerome, Becker, Mike, Kulak, Agnieszka, Allanore, Yannick, Distler, Oliver, Clements, Philip, Cutolo, Maurizio, Czirjak, Laszlo, Damjanov, Nemanja, del Galdo, Francesco, Denton, Christopher P., Distler, Jörg H W, Foeldvari, Ivan, Figelstone, Kim, Frerix, Marc, Furst, Daniel E., Guiducci, Serena, Hunzelmann, Nicolas, Khanna, Dinesh, Matucci-Cerinic, Marco, Herrick, Ariane L., van den Hoogen, Frank, van Laar, Jacob M., Riemekasten, Gabriela, Silver, Richard, Smith, Vanessa, Sulli, Alberto, Tarner, Ingo, Tyndall, Alan, Welling, Joep, Wigley, Frederic, Valentini, Gabriele, Walker, Ulrich A., Zulian, Francesco, Müller-Ladner, Ulf, Daikeler, Thomas, Lanciano, Elisabetta, Becvár, Radim, Tomcik, Michal, Gindzienska-Sieskiewicz, Ewa, Iudici, Michele, Rednic, Simona, Vlachoyiannopoulos, Panayiotis G., Caporali, Roberto, Carreira, Patricia E., Novak, Srdan, Minier, Tünde, Kucharz, Eugene J., Gabrielli, Armando, Moroncini, Gianluca, Airo, Paolo, Hesselstrand, Roger, Martinovic, Duska, Radic, Mislav, Marasovic-Krstulovic, Daniela, Braun-Moscovici, Yolanda, Monaco, Andrea Lo, Morovic-Vergles, Jadranka, Culo, Melanie I., Henes, Jörg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Michalska-Jakubus, Malgorzata, Seidel, Matthias F., Klinik, Medizinische, Hasler, Paul, Da Silva, José A Pereira, Salvador, Maria J., Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Ananieva, Lidia P., Beretta, Lorenzo, Szucs, Gabriella, Szamosi, Szilvia, de la Puente Bujidos, Carlos, Midtvedt, Øyvind, Hoffmann-Vold, Anna Maria, Launay, David, Hachulla, Eric, Riccieri, Valeria, Ionescu, Ruxandra, Opris, Daniela, Mihai, Carina, Herrgott, Ilka, Beyer, Christian, Ingegnoli, Francesca, von Mühlen, Carlos Alberto, Alegre-Sancho, Juan José, Beltran-Catalan, Emma, Aringer, Martin, Fantana, Julia, Leuchten, Nicolai, Tausche, Anne Kathrin, Langhe, Ellen De, Vanthuyne, Marie, Anic, Branimir, Barešic, Marko, Mayer, Miroslav, üprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Jimenez, Sergio A., Popa, Serghei, Agachi, Svetlana, Zenone, Thierry, Stebbings, Simon, Dockerty, Joanne, Vacca, Alessandra, Schollum, Joanna, Veale, Douglas J., Toloza, Sergio, Xu, Dong, Olas, Jacek, Rosato, Edoardo, Foti, Rosario, Adler, Sabine, Dan, Diana, Wiesik-Szewczyk, Ewa, Olesinska, Marzena, Kayser, Cristiane, Fathi, Nihal, de la Peña Lefebvre, Paloma García, and Imbert, Bernard

Published
2017

29. Long-term outcomes of the WEGENT trial on remission-maintenance for granulomatosis with polyangiitis or microscopic polyangiitis

Author

Puéchal, Xavier, Pagnoux, Christian, Perrodeau, Elodie, Hamidou, Mohamed, Boffa, Jean-Jacques, Kyndt, Xavier, Lifermann, François, Papo, Thomas, Merrien, Dominique, Smail, Amar, Delaval, Philippe, Hanrotel-Saliou, Catherine, Imbert, Bernard, Khouatra, Chahéra, Lambert, Marc, Leské, Charles, Ly, Kim, Pertuiset, Edouard, Roblot, Pascal, Ruivard, Marc, Subra, Jean-François, Viallard, Jean-François, Terrier, Benjamin, Cohen, Pascal, Mouthon, Luc, Le Jeunne, Claire, Ravaud, Philippe, Guillevin, Loïc, Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Service de médecine interne et centre de référence des maladies rares [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques ( CRESS - U1153 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de médecine interne [Nantes], Université de Nantes ( UN ) -Hôtel-Dieu-Centre hospitalier universitaire de Nantes ( CHU Nantes ), Remodelage et Reparation du Tissu Renal, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Néphrologie, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Tenon [APHP], Service de médecine interne et néphrologie, CH Valenciennes, Service de Médecine Interne [Dax], Hôpital Dax, Hôpital Bichat - Claude Bernard, Centre Hospitalier Compiègne-Noyon, Service de Néphrologie - Médecine Interne, CHU Amiens-Picardie-Hôpital Sud, Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Service de pneumologie, CHU Pontchaillou [Rennes], Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, CHRU - Service de néphrologie, dialyse et transplantation rénale, Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), CHU Grenoble, Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon ( HCL ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), CH Cholet, CHU Limoges, Hopital Réné Dubos, Service de Médecine Interne, Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), CHU Estaing [Clermont-Ferrand], Service de Néphrologie [Angers], Université d'Angers ( UA ) -CHU Angers, Service de Médecine Interne et Maladies Infectieuses [Pessac], CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], CHU Cochin [AP-HP], Club Rhumatismes et Inflammation, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Sorbonne Paris Cité (USPC), Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [APHP], Centre Hospitalier de Dax, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Amiens-Picardie-hôpital Sud, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), CHU Clermont-Ferrand, Hôpital Cochin [AP-HP], Hospices Civils de Lyon (Délégation à la Recherche Clinique, Lyon, France, Trial no. 97.129), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Jonchère, Laurent

Subjects
[SDV] Life Sciences [q-bio], [ SDV ] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

International audience; Objective - Findings from the WEGENT trial and other short-term studies have suggested that azathioprine (AZA) or methotrexate (MTX) could effectively maintain remission of granulomatosis with polyangiitis (Wegener's) (GPA) or microscopic polyangiitis (MPA). This study was undertaken to examine whether differences in rates of relapse or adverse events would appear after discontinuation of these 2 maintenance regimens, when assessed over a longer followup period. Methods - Long-term outcomes in patients enrolled in the WEGENT trial were analyzed according to their randomized treatment group (AZA or MTX). Parameters at trial entry were evaluated as potential prognostic factors for death, relapse, or damage in multivariate models. Results - Data from 10 years of followup were available for 112 (88.8%) of the 126 original trial participants. The median followup time was 11.9 years (95% confidence interval [95% CI] 11.3-12.5 years). In patients receiving AZA and those receiving MTX, the 10-year overall survival rates were 75.1% (95% CI 64.8-86.9%) and 79.9% (95% CI 70.3-90.8%) (P = 0.56), respectively, and relapse-free survival rates were 26.3% (95% CI 17.3-40.1%) and 33.5% (95% CI 23.5-47.7%) (P = 0.29), respectively. No between-treatment differences were observed with regard to rates of relapse, adverse events, damage, survival without severe side effects, and survival without relapse and severe side effects. In analyses limited to the 97 patients with GPA, no between-treatment differences in survival rates were observed. The 10-year relapse-free survival rate was lower in patients with GPA than in patients with MPA. However, in the multivariate analysis, anti-proteinase 3 antineutrophil cytoplasmic antibody (ANCA) positivity, and not GPA, was retained as being independently associated with the relapse rate. Conclusion - The results of this long-term analysis confirm that AZA and MTX are comparable treatment options for maintaining remission of GPA or MPA. Despite achieving good overall survival with these treatments, relapse rates, adverse events, and damage remain matters of concern and further studies are needed to reduce their frequency in these ANCA-associated vasculitides.

Published
2016

30. Intravenous immunoglobulins in systemic sclerosis: Data from a French nationwide cohort of 46 patients and review of the literature

Author

Sanges, Sébastien, primary, Rivière, Sébastien, additional, Mekinian, Arsène, additional, Martin, Thierry, additional, Le Quellec, Alain, additional, Chatelus, Emmanuel, additional, Lescoat, Alain, additional, Jego, Patrick, additional, Cazalets, Claire, additional, Quéméneur, Thomas, additional, Le Gouellec, Noémie, additional, Senet, Patricia, additional, Francès, Camille, additional, Deroux, Alban, additional, Imbert, Bernard, additional, Fain, Olivier, additional, Boukari, Latifatou, additional, Sené, Thomas, additional, Deligny, Christophe, additional, Mathian, Alexis, additional, Agard, Christian, additional, Pugnet, Grégory, additional, Speca, Silvia, additional, Dubucquoi, Sylvain, additional, Hatron, Pierre-Yves, additional, Hachulla, Éric, additional, and Launay, David, additional

Published
2017
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32. Involvement of Candida albicans Cell Wall Proteins in the Adherence of Blastospores to Human Buccal Epithelial Cells

Author

Michèle Mallié, Christine Imbert-Bernard, J.-M. Bastide, and Alexis Valentin

Subjects
biology, Mouth Mucosa, Buccal administration, Adhesion, Spores, Fungal, biology.organism_classification, Applied Microbiology and Biotechnology, Chromatography, Affinity, Epithelium, Corpus albicans, Yeast, Microbiology, Fungal Proteins, Molecular Weight, Cell wall, Cell Wall, Concanavalin A, Candida albicans, Cell Adhesion, biology.protein, Humans, Electrophoresis, Polyacrylamide Gel
Abstract

Imbert-Bernard, C., Valentin, A., Mallie, M., and Bastide, J.-M. 1995. Involvement of Candida albicans cell wall proteins in the adherence of blastospores to human buccal epithelial cells. Experimental Mycology 19, 247-253. The adherence of Candida albicans to epithelial cells is one of the first steps in the development of candidiasis and therefore could constitute an interesting target for the prevention of infection. A yeast cell wall extract was prepared by using a C. albicans isolate (IVP 1453) highly adherent to buccal epithelial cells (BECs). This cell wall extract was separated by concanavalin A-affinity chromatography into two fractions referred to as Fr1 (proteic fraction) and Fr2 (mannoproteic fraction). The adhesion activity was mostly associated with the proteic fraction. This fraction was therefore retained and further fractionated by ion-exchange chromatography into two other fractions, referred to as Fr1a and Fr1b. The adhesion activity was mostly associated with the Fr1b fraction (56.4% adherence inhibition); it was not specific to the C. albicans isolate used during the cell wall extract preparation. The Fr1b fraction contained four major proteins with molecular masses of 30, 38, 47, and 54 kDa. Among these four proteins, those with molecular masses of 38 and 54 kDa could be involved in adherence mechanisms of C. albicans to human BECs.

Published
1995

33. Relationship between fluconazole sensitivity ofCandida albicans isolates from HIV positive patients and serotype, adherence and CD4+ lymphocyte count

Author

M. Mallie, Jacques Reynes, J. M. Bastide, C. Imbert-Bernard, and Alexis Valentin

Subjects
Microbiology (medical), Serotype, medicine.medical_specialty, Lymphocyte, Microbial Sensitivity Tests, Microbiology, Medical microbiology, Candidiasis, Oral, Candida albicans, HIV Seropositivity, Confidence Intervals, medicine, Humans, Serotyping, Fluconazole, AIDS-Related Opportunistic Infections, biology, Mouth Mucosa, General Medicine, Buccal administration, biology.organism_classification, Virology, Corpus albicans, In vitro, CD4 Lymphocyte Count, Infectious Diseases, medicine.anatomical_structure, HIV-1, medicine.drug
Abstract

The sensitivity of fluconazole, serotype and adherence to buccal epithelial cells of 46 Candida albicans isolates was studied in vitro. Strains were isolated from 18 HIV-positive patients with variable CD4+ lymphocyte counts who were receiving long-term fluconazole therapy. Results showed that sensitivity to fluconazole correlated with serotype. Of the sensitive isolates 81.5% were serotype A and 18.5% serotype B, whereas of the resistant isolates 37.5% were serotype A and 62.5% serotype B. Sensitivity to fluconazole also correlated with adherence capacity, resistant isolates showing slightly less adherence to buccal epithelial cells than sensitive isolates. Weakly adherent isolates represented 87% of resistant isolates and only 63% of sensitive isolates. Resistant strains were isolated in highly immunocompromised patients. All strains isolated in patients with CD4+ lymphocyte counts above 200 lymphocytes/microliters were sensitive, whereas intermediate and resistant strains were isolated in patients with counts below 200 lymphocytes/microliters. Statistical analyses showed no correlation between adherence of isolates to buccal epithelial cells and CD4+ lymphocyte counts.

Published
1994

35. Toxoplasma gondii: in vivo and in vitro cystogenesis of the virulent RH strain

Author

C, De Champs, C, Imbert-Bernard, A, Belmeguenai, J, Ricard, H, Pelloux, E, Brambilla, and P, Ambroise-Thomas

Subjects
Male, Virulence, Antibodies, Protozoan, Brain, Fibroblasts, Hydrogen-Ion Concentration, Rats, Inbred F344, Cell Line, Rats, Disease Models, Animal, Mice, Microscopy, Electron, Toxoplasmosis, Animal, Immunoglobulin G, Animals, Humans, Female, Rats, Wistar, Toxoplasma
Abstract

Models of cystogenesis were developed in vivo and in vitro with the virulent RH Toxoplasma gondii strain. In vivo in a first assay, 7.5-wk-old Fischer rats were inoculated intraperitoneally with 10(7) tachyzoites from mouse peritoneal fluid. Between 9 and 17 wk after inoculation, 1-5 cysts of 40-60 microns, containing numerous bradyzoites, were isolated from the brain of 5 of the rats. In a second assay, 24 Wistar rats were inoculated intraperitoneally with 10(2), 10(4), and 10(8) tachyzoites at 7, 11, 24, and 46 days. An inoculum of 10(8) was lethal for the 6 rats inoculated before 46 days and there was no correlation between the inoculum and the number of cysts except in the rats inoculated at 46 days. Fibroblast cell cultures (MRC5), at pH 7.5, were destroyed in 72 hr by 10(5)/ml RH-strain tachyzoites. However, when pH culture was increased to pH 8, up to 140 cysts were observed with indirect fluorescent antibody staining. Electron microscopy showed a 15 microns cyst, containing bradyzoites and surrounded by a 0.5-1-micron irregular wall.

Published
1997

37. Detection of Antiendothelial Cell Antibodies by an Enzyme-Linked Immunosorbent Assay Using Antigens from Cell Lysate: Minimal Interference with Antinuclear Antibodies and Rheumatoid Factors

Author

Drouet, Christian, primary, Nissou, Marie-France, additional, Ponard, Denise, additional, Arvieux, Josiane, additional, Dumestre-Pérard, Chantal, additional, Gaudin, Philippe, additional, Imbert, Bernard, additional, Massot, Christian, additional, and Sarrot-Reynauld, Françoise, additional

Published
2003
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44. Relationship between fluconazole sensitivity of Candida albicans isolates from HIV positive patients and serotype, adherence and CD4+ lymphocyte count.

Author

Imbert-Bernard, C., Valentin, A., Reynes, J., Mallié, M., and Bastide, J.

Abstract

The sensitivity to fluconazole, serotype and adherence to buccal epithelial cells of 46 Candida albicans isolates was studied in vitro. Strains were isolated from 18 HIV-positive patients with variable CD4+ lymphocyte counts who were receiving long-term fluconazole therapy. Results showed that sensitivity to fluconazole correlated with serotype. Of the sensitive isolates 81.5 % were serotype A and 18.5 % serotype B, whereas of the resistant isolates 37.5 % were serotype A and 62.5 % serotype B. Sensitivity to fluconazole also correlated with adherence capacity, resistant isolates showing slightly less adherence to buccal epithelial cells than sensitive isolates. Weakly adherent isolates represented 87 % of resistant isolates and only 63 % of sensitive isolates. Resistant strains were isolated in highly immunocompromised patients. All strains isolated in patients with CD4+ lymphocyte counts above 200 lymphocytes/µl were sensitive, whereas intermediate and resistant strains were isolated in patients with counts below 200 lymphocytes/µl. Statistical analyses showed no correlation between adherence of isolates to buccal epithelial cells and CD4+ lymphocyte counts. [ABSTRACT FROM AUTHOR]

Published
1994
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45. Rivaroxaban vs Dalteparin in Cancer-Associated Thromboembolism

Author

Planquette, Benjamin, Bertoletti, Laurent, Charles-Nelson, Anaïs, Laporte, Silvy, Grange, Claire, Mahé, Isabelle, Pernod, Gilles, Elias, Antoine, Couturaud, Francis, Falvo, Nicolas, Sevestre, Marie Antoinette, Ray, Valérie, Burnod, Alexis, Brebion, Nicolas, Roy, Pierre-Marie, Timar-David, Miruna, Aquilanti, Sandro, Constans, Joel, Bura-Riviere, Alessandra, Brisot, Dominique, Chatellier, Gilles, Sanchez, Olivier, Meyer, Guy, Girard, Philippe, Mismetti, Patrick, Meyer, Guy, Mismetti, Patrick, Chatellier, Gilles, Laporte, Silvy, Decousus, Hervé, Mahé, Isabelle, Falvo, Nicolas, Delluc, Aurélien, Bertoletti, Laurent, Laneau, Christine, Dinut, Aurelia, Aegerter, Philippe, Emmerich, Joseph, Decousus, Hervé, Girard, Philippe, Messas, Emmanuel, Revel, Marie-Pierre, Charles-Nelson, Anaïs, Laporte, Silvy, Bertoletti, Laurent, Acassat, Sandrine, Mismetti, Patrick, Meyer, Guy, Planquette, Benjamin, Sanchez, Olivier, Mahé, Isabelle, Plaisance, Ludovic, Poénou, Géraldine, Pernod, Gilles, Imbert, Bernard, Zenati, Nora, Couturaud, Francis, Le Mao, Raphael, Hoffmann, Clément, Elias, Antoine, Elias, Marie, Falvo, Nicolas, Loffroy, Romaric, Jandot, Maud, Sevestre, Marie-Antoinette, Modéliar Rémond, Santhi Samy, Ray, Valérie, Burnod, Alexis, Roy, Pierre-Marie, Moumneh, Thomas, Henni, Samir, Brebion, Nicolas, Timor-David, Miruna, Constans, Joël, Boulon, Carine, Aquilanti, Sandro, Brisot, Dominique, Bura-Rivière, Alessandra, Bertoletti, Laurent, Couturaud, Francis, Girard, Philippe, Laporte, Silvy, Mahé, Isabelle, Meyer, Guy, Mismetti, Patrick, Planquette, Benjamin, and Sanchez, Olivier

Abstract

Direct oral anticoagulants (DOACs) are an alternative to low-molecular-weight heparin for treating cancer-associated VTE.

Published
2021
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46. Toxoplasma gondii: In vivo and in vitro cystogenesis of the virulent RH strain

Author

Hervé Pelloux, J. Ricard, A. Belmeguenai, C. Imbert-Bernard, E. Brambilla, C. De Champs, and P. Ambroise-Thomas

Subjects
biology, Inoculation, Peritoneal fluid, Virulence, Toxoplasma gondii, biology.organism_classification, In vitro, Microbiology, medicine.anatomical_structure, Cell culture, In vivo, medicine, Parasitology, Fibroblast, Ecology, Evolution, Behavior and Systematics
Abstract

Models of cystogenesis were developed in vivo and in vitro with the virulent RH Toxoplasma gondii strain. In vivo in a first assay, 7.5-wk-old Fischer rats were inoculated intraperitoneally with 10(7) tachyzoites from mouse peritoneal fluid. Between 9 and 17 wk after inoculation, 1-5 cysts of 40-60 microns, containing numerous bradyzoites, were isolated from the brain of 5 of the rats. In a second assay, 24 Wistar rats were inoculated intraperitoneally with 10(2), 10(4), and 10(8) tachyzoites at 7, 11, 24, and 46 days. An inoculum of 10(8) was lethal for the 6 rats inoculated before 46 days and there was no correlation between the inoculum and the number of cysts except in the rats inoculated at 46 days. Fibroblast cell cultures (MRC5), at pH 7.5, were destroyed in 72 hr by 10(5)/ml RH-strain tachyzoites. However, when pH culture was increased to pH 8, up to 140 cysts were observed with indirect fluorescent antibody staining. Electron microscopy showed a 15 microns cyst, containing bradyzoites and surrounded by a 0.5-1-micron irregular wall.

47. Update of EULAR recommendations for the treatment of systemic sclerosis

Author

Kowal-Bielecka O., Fransen J., Avouac J., Becker M., Kulak A., Allanore Y., Distler O., Clements P., Cutolo M., Czirjak L., Damjanov N., Del Galdo F., Denton C. P., Distler J. H. W., Foeldvari I., Figelstone K., Frerix M., Furst D. E., Guiducci S., Hunzelmann N., Khanna D., Matucci-Cerinic M., Herrick A. L., Van Den Hoogen F., Van Laar J. M., Riemekasten G., Silver R., Smith V., Sulli A., Tarner I., Tyndall A., Welling J., Wigley F., Valentini G., Walker U. A., Zulian F., Muller-Ladner U., Daikeler T., Lanciano E., Becvar R., Tomcik M., Gindzienska-Sieskiewicz E., Cuomo G., Iudici M., Rednic S., Vlachoyiannopoulos P. G., Caporali R., Carreira P. E., Novak S., Minier T., Kucharz E. J., Gabrielli A., Moroncini G., Airo' P., Hesselstrand R., Martinovic D., Radic M., Marasovic-Krstulovic D., Braun-Moscovici Y., Balbir-Gurman A., Lo Monaco A., Caramaschi P., Morovic-Vergles J., Henes J., Ortiz Santamaria V., Heitmann S., Krasowska D., Seidel M. F., Hasler P., Pereira Da Silva J. A., Salvador M. J., Stamenkovic B., Stankovic A., Tikly M., Ananieva L. P., Beretta L., Szucs G., Szamosi S., de la Puente Bujidos C., Midtvedt O., Hoffmann-Vold A. -M., Launay D., Hachulla E., Riccieri V., Ionescu R., Opris D., Mihai C., Herrgott I., Beyer C., Ingegnoli F., von Muhlen C. A., Alegre-Sancho J. J., Beltran-Catalan E., Aringer M., Fantana J., Leuchten N., Tausche A. -K., De Langhe E., Vanthuyne M., Anic B., Baresic M., Mayer M., Uprus M., Otsa K., Yavuz S., Granel B., Azevedo V. F., Muller C., Jimenez S. A., Popa S., Agachi S., Zenone T., Stebbings S., Dockerty J., Vacca A., Schollum J., Veale D. J., Toloza S., Xu D., Olas J., Rosato E., Foti R., Adler S., Dan D., Wiesik-Szewczyk E., Olesinska M., Kayser C., Fathi N., de la Pena Lefebvre P. G., Imbert B., Kowal-Bielecka, O., Fransen, J., Avouac, J., Becker, M., Kulak, A., Allanore, Y., Distler, O., Clements, P., Cutolo, M., Czirjak, L., Damjanov, N., Del Galdo, F., Denton, C. P., Distler, J. H. W., Foeldvari, I., Figelstone, K., Frerix, M., Furst, D. E., Guiducci, S., Hunzelmann, N., Khanna, D., Matucci-Cerinic, M., Herrick, A. L., Van Den Hoogen, F., Van Laar, J. M., Riemekasten, G., Silver, R., Smith, V., Sulli, A., Tarner, I., Tyndall, A., Welling, J., Wigley, F., Valentini, G., Walker, U. A., Zulian, F., Muller-Ladner, U., Daikeler, T., Lanciano, E., Becvar, R., Tomcik, M., Gindzienska-Sieskiewicz, E., Cuomo, G., Iudici, M., Rednic, S., Vlachoyiannopoulos, P. G., Caporali, R., Carreira, P. E., Novak, S., Minier, T., Kucharz, E. J., Gabrielli, A., Moroncini, G., Airo', P., Hesselstrand, R., Martinovic, D., Radic, M., Marasovic-Krstulovic, D., Braun-Moscovici, Y., Balbir-Gurman, A., Lo Monaco, A., Caramaschi, P., Morovic-Vergles, J., Henes, J., Ortiz Santamaria, V., Heitmann, S., Krasowska, D., Seidel, M. F., Hasler, P., Pereira Da Silva, J. A., Salvador, M. J., Stamenkovic, B., Stankovic, A., Tikly, M., Ananieva, L. P., Beretta, L., Szucs, G., Szamosi, S., de la Puente Bujidos, C., Midtvedt, O., Hoffmann-Vold, A. -M., Launay, D., Hachulla, E., Riccieri, V., Ionescu, R., Opris, D., Mihai, C., Herrgott, I., Beyer, C., Ingegnoli, F., von Muhlen, C. A., Alegre-Sancho, J. J., Beltran-Catalan, E., Aringer, M., Fantana, J., Leuchten, N., Tausche, A. -K., De Langhe, E., Vanthuyne, M., Anic, B., Baresic, M., Mayer, M., Uprus, M., Otsa, K., Yavuz, S., Granel, B., Azevedo, V. F., Muller, C., Jimenez, S. A., Popa, S., Agachi, S., Zenone, T., Stebbings, S., Dockerty, J., Vacca, A., Schollum, J., Veale, D. J., Toloza, S., Xu, D., Olas, J., Rosato, E., Foti, R., Adler, S., Dan, D., Wiesik-Szewczyk, E., Olesinska, M., Kayser, C., Fathi, N., de la Pena Lefebvre, P. G., Imbert, B., UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (MGD) Service de rhumatologie, Kowal Bielecka, Otylia, Fransen, Jaap, Avouac, Jerome, Becker, Mike, Kulak, Agnieszka, Allanore, Yannick, Distler, Oliver, Clements, Philip, Cutolo, Maurizio, Czirjak, Laszlo, Damjanov, Nemanja, del Galdo, Francesco, Denton, Christopher P., Distler, Jörg H. W., Foeldvari, Ivan, Figelstone, Kim, Frerix, Marc, Furst, Daniel E., Guiducci, Serena, Hunzelmann, Nicola, Khanna, Dinesh, Matucci Cerinic, Marco, Herrick, Ariane L., van den Hoogen, Frank, van Laar, Jacob M., Riemekasten, Gabriela, Silver, Richard, Smith, Vanessa, Sulli, Alberto, Tarner, Ingo, Tyndall, Alan, Welling, Joep, Wigley, Frederic, Valentini, Gabriele, Walker, Ulrich A., Zulian, Francesco, Müller Ladner, Ulf, Daikeler, Thoma, Lanciano, Elisabetta, Becvã¡r, Radim, Tomcik, Michal, Gindzienska Sieskiewicz, Ewa, Iudici, Michele, Rednic, Simona, Vlachoyiannopoulos, Panayiotis G., Caporali, Roberto, Carreira, Patricia E., Novak, Srdan, Minier, Tã¼nde, Kucharz, Eugene J., Gabrielli, Armando, Moroncini, Gianluca, Airo, Paolo, Hesselstrand, Roger, Martinovic, Duska, Radic, Mislav, Marasovic Krstulovic, Daniela, Braun Moscovici, Yolanda, Monaco, Andrea Lo, Morovic Vergles, Jadranka, Culo, Melanie I., Henes, Jã¶rg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Michalska Jakubus, Malgorzata, Seidel, Matthias F., Klinik III, Medizinische, Hasler, Paul, Da Silva, José A. Pereira, Salvador, Maria J., Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Ananieva, Lidia P., Beretta, Lorenzo, Szucs, Gabriella, Szamosi, Szilvia, de la Puente Bujidos, Carlo, Midtvedt, Øyvind, Hoffmann Vold, Anna Maria, Launay, David, Hachulla, Eric, Riccieri, Valeria, Ionescu, Ruxandra, Opris, Daniela, Mihai, Carina, Herrgott, Ilka, Beyer, Christian, Ingegnoli, Francesca, von Mühlen, Carlos Alberto, Alegre Sancho, Juan José, Beltran Catalan, Emma, Aringer, Martin, Fantana, Julia, Leuchten, Nicolai, Tausche, Anne Kathrin, Langhe, Ellen De, Vanthuyne, Marie, Anic, Branimir, Bareå¡ic, Marko, Mayer, Miroslav, Ãœprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Jimenez, Sergio A., Popa, Serghei, Agachi, Svetlana, Zenone, Thierry, Stebbings, Simon, Dockerty, Joanne, Vacca, Alessandra, Schollum, Joanna, Veale, Douglas J., Toloza, Sergio, Xu, Dong, Olas, Jacek, Rosato, Edoardo, Foti, Rosario, Adler, Sabine, Dan, Diana, Wiesik Szewczyk, Ewa, Olesinska, Marzena, Kayser, Cristiane, Fathi, Nihal, de la Peña Lefebvre, Paloma García, Imbert, Bernard, and Cuomo, Giovanna

Subjects
Endothelin Receptor Antagonists, Lung Diseases, Kidney Disease, Delphi Technique, Gastrointestinal Diseases, systemic sclerosis, Scleroderma Renal Crisis, Placebo-controlled study, Angiotensin-Converting Enzyme Inhibitors, Lung Disease, Scleroderma, 0302 clinical medicine, Glucocorticoid, Phosphodiesterase 5 Inhibitor, Immunology and Allergy, skin and connective tissue diseases, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, integumentary system, treatment, genetics and molecular biology (all), Hematopoietic Stem Cell Transplantation, cyclophosphamide, methotrexate, Pulmonary, Orvostudományok, Serotonin Uptake Inhibitor, 3. Good health, Europe, Systematic review, Hypertension, Serotonin Uptake Inhibitors, Cyclophosphamide, Methotrexate, Systemic Sclerosis, Treatment, Fingers, Fluoxetine, Glucocorticoids, Humans, Hypertension, Pulmonary, Kidney Diseases, Phosphodiesterase 5 Inhibitors, Prostaglandins I, Pyrazoles, Pyrimidines, Raynaud Disease, Rheumatology, Scleroderma, Systemic, Ulcer, Immunology, Biochemistry, Genetics and Molecular Biology (all), 030211 gastroenterology & hepatology, Endothelin Receptor Antagonist, Selective Serotonin Reuptake Inhibitors, medicine.drug, Human, medicine.medical_specialty, Gastrointestinal Disease, Klinikai orvostudományok, Riociguat, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Finger, biochemistry, Intensive care medicine, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, Systemic Sclerosi, 030203 arthritis & rheumatology, business.industry, Systemic, Angiotensin-Converting Enzyme Inhibitor, medicine.disease, Transplantation, Clinical research, Pyrimidine, immunology and allergy, rheumatology, immunology, Pyrazole, Physical therapy, business, Rheumatism
Abstract

The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the previous treatment recommendations was performed according to EULAR standard operating procedures. The task force consisted of 32 SSc clinical experts from Europe and the USA, 2 patients nominated by the pan-European patient association for SSc (Federation of European Scleroderma Associations (FESCA)), a clinical epidemiologist and 2 research fellows. All centres from the EULAR Scleroderma Trials and Research group were invited to submit and select clinical questions concerning SSc treatment using a Delphi approach. Accordingly, 46 clinical questions addressing 26 different interventions were selected for systematic literature review. The new recommendations were based on the available evidence and developed in a consensus meeting with clinical experts and patients. The procedure resulted in 16 recommendations being developed (instead of 14 in 2009) that address treatment of several SSc-related organ complications: Raynaud's phenomenon (RP), digital ulcers (DUs), pulmonary arterial hypertension (PAH), skin and lung disease, scleroderma renal crisis and gastrointestinal involvement. Compared with the 2009 recommendations, the 2016 recommendations include phosphodiesterase type 5 (PDE-5) inhibitors for the treatment of SSc-related RP and DUs, riociguat, new aspects for endothelin receptor antagonists, prostacyclin analogues and PDE-5 inhibitors for SSc-related PAH. New recommendations regarding the use of fluoxetine for SSc-related RP and haematopoietic stem cell transplantation for selected patients with rapidly progressive SSc were also added. In addition, several comments regarding other treatments addressed in clinical questions and suggestions for the SSc research agenda were formulated. These updated data-derived and consensus-derived recommendations will help rheumatologists to manage patients with SSc in an evidence-based way. These recommendations also give directions for future clinical research in SSc.

Published
2017

48. Digital ulcers in systemic sclerosis are strongly associated with digital arterial disease: a finger-by-finger analysis of Finger Brachial Pressure Index Measurements.

Author

Blaise S, Boulon C, Mangin M, Senet P, Lazareth I, Imbert B, Lapebie FX, Lacroix P, Seinturier C, Constans J, and Carpentier PH

Abstract

Objectives: The digital ulcers of systemic sclerosis are disabling and frequent· Their pathogenesis involves a capillary microangiopathy and a digital arterial disease that few studies were able to quantify up to now. A multicentre observational study about the predictive value of capillaroscopy in systemic sclerosis offered us the opportunity to evaluate further the complementary information provided by both capillary and arterial evaluations., Methods: During the SCLEROCAP study, five out of the nine centers performed a systematic evaluation of the finger brachial pressure index (FBPI) in the last four fingers of both hands at baseline, using the same laser-doppler device. In the present work, FBPI measurements were compared between fingers with vs without digital ulcers or scars, before and after adjusting for the capillaroscopic pattern and systemic factors., Results: FBPI measurements were performed in 2537 fingers from 326 patients. Active ulcers or scars were found in 10·8% of those fingers, more often on the right hand, and in the second and third fingers. FBPI was lower than 0·70 in 26% of all fingers and in 57·5% of those with ulcers. A strong association was found between a low FBPI and the presence of digital ulcers, even after adjusting for capillaroscopic pattern, ulcer location and the patient himself., Conclusion: These results confirm the importance of digital arterial disease in the pathogenesis of digital ulcers of systemic sclerosis, which is independent from the microangiopathy. FBPI measurements complement the information provided by capillaroscopy and might have an important predictive value for subsequent digital ulcers., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2024
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49. Correlation between capillaroscopic classifications and severity in systemic sclerosis: results from SCLEROCAP study at inclusion.

Author

Boulon C, Aiouaz S, Blaise S, Mangin M, Decamps-Le Chevoir J, Senet P, Lazareth I, Baudot N, Tribout L, Imbert B, Lapebie FX, Lacroix P, Truchetet ME, Seneschal J, Solanilla A, Skopinski S, Lazaro E, Quéré I, Pistorius MA, Le Hello C, Perez P, Carpentier P, and Constans J

Subjects
Capillaries, Female, Humans, Male, Nails, Prospective Studies, Severity of Illness Index, Microscopic Angioscopy methods, Scleroderma, Systemic classification, Scleroderma, Systemic pathology, Skin Ulcer classification, Skin Ulcer pathology
Abstract

Objectives: We assessed the correlation between severity of systemic sclerosis (SSc) and current staging systems based on nailfold capillaroscopy., Methods: SCLEROCAP is a multicenter prospective study including consecutive scleroderma patients who have a yearly routine follow-up with capillaroscopy and digital blood pressure measurement. Capillaroscopy images were read by two observers blinded from each other, then by a third one in the case of discordance. A follow-up of 3 years is planned. The present study assessed the correlation between severity of systemic sclerosis (SSc) and current staging systems based on nail fold capillaroscopy at enrollment in the SCLEROCAP study. Univariate and multivariate logistic regression analysis was performed for both the Maricq and Cutolo classifications., Results: SCLEROCAP included 387 patients in one year. Maricq's active and Cutolo's late classifications were very similar. In multivariate analysis, the number of digital ulcers (OR for 2 ulcers or more, respectively 2.023 [1.074-3.81] and 2.596 [1.434-4.699]) and Rodnan's skin score >15 (OR respectively 32.007 [6.457-158.658] and 18.390 [5.380-62.865]) correlated with Maricq's active and Cutolo's late stages. Haemoglobin rate correlated with Cutolo's late stage (hemoglobin<100 vs. >120 g/dl: OR 0.223 [0.051-0.980]), and total lung capacity with Maricq's active one: increase in 10%: OR0.833 [0.717-0.969]., Conclusions: The correlations found between capillaroscopy and severity of SSc are promising before the ongoing prospective study definitively assesses whether capillaroscopy staging predicts complications of SSc. Only two capillaroscopic patterns seem useful: one involving many giant capillaries and haemorrhages and the other with severe capillary loss.

Published
2019

50. On-Demand Sildenafil as a Treatment for Raynaud Phenomenon: A Series of n-of-1 Trials.

Author

Roustit M, Giai J, Gaget O, Khouri C, Mouhib M, Lotito A, Blaise S, Seinturier C, Subtil F, Paris A, Cracowski C, Imbert B, Carpentier P, Vohra S, and Cracowski JL

Subjects
Adult, Cross-Over Studies, Data Interpretation, Statistical, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome, Phosphodiesterase 5 Inhibitors administration & dosage, Phosphodiesterase 5 Inhibitors adverse effects, Raynaud Disease drug therapy, Sildenafil Citrate administration & dosage, Sildenafil Citrate adverse effects, Vasodilator Agents administration & dosage, Vasodilator Agents adverse effects
Abstract

Background: Treatment of Raynaud phenomenon (RP) with phosphodiesterase-5 inhibitors has shown moderate efficacy. Adverse effects decrease the risk-benefit profile of these drugs, and patients may not be willing to receive long-term treatment. On-demand single doses before or during exposure to cold may be a good alternative., Objective: To assess the efficacy and safety of on-demand sildenafil in RP., Design: Series of randomized, double-blind, n-of-1 trials. (ClinicalTrials.gov: NCT02050360)., Setting: Outpatients at a French university hospital., Participants: Patients with primary or secondary RP., Intervention: Each trial consisted of a multiple crossover study in a single patient. Repeated blocks of 3 periods of on-demand treatment were evaluated: 1 week of placebo, 1 week of sildenafil at 40 mg per dose, and 1 week of sildenafil at 80 mg per dose, with a maximum of 2 doses daily., Measurements: Raynaud Condition Score (RCS) and frequency and daily duration of attacks. Skin blood flow in response to cooling also was assessed with laser speckle contrast imaging. Mixed-effects models were used and parameters were estimated in a Bayesian framework to determine individual and aggregated efficacy., Results: 38 patients completed 2 to 5 treatment blocks. On the basis of aggregated data, the probability that sildenafil at 40 mg or 80 mg was more effective than placebo was greater than 90% for all outcomes (except for RCS with sildenafil, 80 mg). However, the aggregated effect size was not clinically relevant. Yet, substantial heterogeneity in sildenafil's efficacy was observed among participants, with clinically relevant efficacy in some patients., Limitation: The response to sildenafil was substantially heterogeneous among patients., Conclusion: Despite a high probability that sildenafil is superior to placebo, substantial heterogeneity was observed in patient response and aggregated results did not show that on-demand sildenafil has clinically relevant efficacy. In this context, the use of n-of-1 trials may be an original and relevant approach in RP., Primary Funding Source: GIRCI (Groupement Interrégional de Recherche Clinique et d'Innovation) Auvergne Rhône-Alpes (academic funding) and Pfizer.

Published
2018
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