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1. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author: Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, Sánchez, María José, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, Ferrari, Pietro, Clarke, Robert, Boutron, Marie-Christine, Severi, Gianluca, MacDonald, Conor, Providencia, Rui, Masala, Giovanna, Zamora Ros, Raul, Boer, Jolanda, Verschuren, Wm Monique, Cawthon, Peggy, Schierbeck, Louise L, Cooper, Cyrus, Schulze, Matthias B, Bergmann, Manuela M, Hannemann, Anke, Kiechl, Stefan, Brenner, Hermann, van Schoor, Natasja M, Albertorio, Juan R, Sacerdote, Carlotta, Linneberg, Allan, Kårhus, LineL, Huerta, José María, Imaz, Liher, Joergensen, Christel, Ben-Shlomo, Yoav, Lundqvist, Annamari, Gallacher, John, Sattar, Naveed, Wood, Angela M, Wareham, Nicholas J, Nordestgaard, Børge G, Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S, and Burgess, Stephen
Published: 2024
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2. Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements

Author: Smith-Byrne, Karl, primary, Cerani, Agustin, additional, Guida, Florence, additional, Zhou, Sirui, additional, Agudo, Antonio, additional, Aleksandrova, Krasimira, additional, Barricarte, Aurelio, additional, Barranco, Miguel Rodríguez, additional, Bochers, Christoph H., additional, Gram, Inger Torhild, additional, Han, Jun, additional, Amos, Christopher I., additional, Hung, Rayjean J., additional, Grankvist, Kjell, additional, Nøst, Therese Haugdhal, additional, Imaz, Liher, additional, Chirlaque-López, María Dolores, additional, Johansson, Mikael, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Martin, Richard M., additional, McKay, James D., additional, Pala, Valeria, additional, Robbins, Hilary A., additional, Sandanger, Torkjel M., additional, Schibli, David, additional, Schulze, Matthias B., additional, Travis, Ruth C., additional, Vineis, Paolo, additional, Weiderpass, Elisabete, additional, Brennan, Paul, additional, Johansson, Mattias, additional, and Richards, J. Brent, additional
Published: 2022
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3. Genetically determined reproductive aging and coronary heart disease: a bidirectional two-sample Mendelian Randomization

Author: Dam, Veerle, Onland-Moret, N. Charlotte, Burgess, Stephen, Chirlaque, Maria Dolores, Peters, Sanne A.E., Schuit, Ewoud, Tikk, Kaja, Weiderpass, Elisabete, Oliver-Williams, Clare, Wood, Angela M., Tjønneland, Anne, Dahm, Christina C, Overvad, Kim, Boutron-Rualt, Marie-Christine, Schulze, Matthias B., Trichopoulou, Antonia, Ferrari, Pietro, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Matullo, Giuseppe, Panico, Salvatore, Boer, Jolanda M. A., Verschuren, W.M. Monique, Waaseth, Marit, Pérez, María José Sánchez, Amiano, Pilar, Imaz, Liher, Moreno-Iribas, Conchi, Melander, Olle, Harlid, Sophia, Nordendahl, Maria, Wennberg, Patrik, Key, Timothy J., Riboli, Elio, Santiuste, Carmen, Kaaks, Rudolf, Katzke, Verena, Langenberg, Claudia, Wareham, Nicholas J., Schunkert, Heribert, Erdmann, Jeanette, Willenborg, Christina, Hengstenberg, Christian, Kleber, Marcus E., Delgado, Graciela, März, Winfried, Kanoni, Stavroula, Dedoussis, George, Deloukas, Panos, Nikpay, Majid, McPherson, Ruth, Scholz, Markus, Teren, Andrej, Butterworth, Adam S., and van der Schouw, Yvonne T.
Subjects: Mendelian Randomization, Reproductive aging, coronary heart disease, risk factors, cardiovascular diseases
Abstract: Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Design: Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Participants: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. Main Outcome Measures: CHD, CHD risk factors, and ANM. Results: Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Conclusion: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.
Published: 2022
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4. Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in preadolescents

Author: Cabré-Riera, Alba, van Wel, Luuk, Liorni, Ilaria, Koopman-Verhoeff, M Elisabeth, Imaz, Liher, Ibarluzea, Jesús, Huss, Anke, Wiart, Joe, Vermeulen, Roel, Joseph, Wout, Capstick, Myles, Vrijheid, Martine, Cardis, Elisabeth, Röösli, Martin, Eeftens, Marloes, Thielens, Arno, Tiemeier, Henning, Guxens, Mònica, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), European Commission, Child and Adolescent Psychiatry / Psychology, and Erasmus MC other
Subjects: medicine.medical_specialty, Evening, Technology and Engineering, SYMPTOMS, DEVICES, animal structures, Wireless technology, Adolescent, Population, Audiology, Biochemistry, PHONE BASE STATIONS, Phone, Environmental Science(all), Medicine, Humans, QUALITY, EXPOSURE, education, Child, ADOLESCENT SLEEP, General Environmental Science, education.field_of_study, Sleep disorder, business.industry, Radio waves, TECHNOLOGY USE, Brain, Electromagnetic fields, Environmental Exposure, medicine.disease, Sleep time, Mobile phone, MEDIA USE, technology, Telecommunications, Wireless, UPDATE, Generation R, Sleep (system call), RF-EMF, business, Sleep, Cell phone use, Cell Phone
Abstract: [EN] Objective: To investigate the association of estimated all-day and evening whole-brain radiofrequency electromagnetic field (RF-EMF) doses with sleep disturbances and objective sleep measures in preadolescents. Methods: We included preadolescents aged 9-12 years from two population-based birth cohorts, the Dutch Generation R Study (n = 974) and the Spanish INfancia y Medio Ambiente Project (n = 868). All-day and evening overall whole-brain RF-EMF doses (mJ/kg/day) were estimated for several RF-EMF sources including mobile and Digital Enhanced Cordless Telecommunications (DECT) phone calls (named phone calls), other mobile phone uses, tablet use, laptop use (named screen activities), and far-field sources. We also estimated all-day and evening whole-brain RF-EMF doses in these three groups separately (i.e. phone calls, screen activities, and far-field). The Sleep Disturbance Scale for Children was completed by mothers to assess sleep disturbances. Wrist accelerometers together with sleep diaries were used to measure sleep characteristics objectively for 7 consecutive days. Results: All-day whole-brain RF-EMF doses were not associated with self-reported sleep disturbances and objective sleep measures. Regarding evening doses, preadolescents with high evening whole-brain RF-EMF dose from phone calls had a shorter total sleep time compared to preadolescents with zero evening whole-brain RF-EMF dose from phone calls [-11.9 min (95%CI -21.2; -2.5)]. Conclusions: Our findings suggest the evening as a potentially relevant window of RF-EMF exposure for sleep. However, we cannot exclude that observed associations are due to the activities or reasons motivating the phone calls rather than the RF-EMF exposure itself or due to chance finding. This work was supported by the European Union Seventh Framework Program (FP7/2007-2013 No. 603794 GERoNiMO project) . Arno Thielens is a postdoctoral fellow of the Research Foundation Flanders (FWO) under grant agreement no. 12U1417N. INMA-Sabadell: This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds, MS13/00054, CPII18/00018; PI17/01340 incl. FEDER funds) , CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822) , Fundacio La Marato de TV3 (090430) , Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds) , French Agency for Food, Environmental and Occupational Health & Safety (EST-2016 RF-21, EST/2013/2/22) , EU Commission (261357, 308333, 603794 and 634453) .We also acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the "Centro de Excelencia Severo Ochoa 2019-2023" Program (CEX2018-000806-S) , and support from the Generalitat de Catalunya through the CERCA Program". INMA-Gipuzkoa: This study was funded by grants from Instituto de Salud Carlos III (FIS-PI13/02187) , CIBERESP, Department of Health of the Basque Government (2015111065) , and the Provincial Government of Gipuzkoa (DFG15/221) and annual agreements with the municipal-ities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain) . The Generation R Study: The general design of the Generation R Study is supported by the Erasmus Medical Center-Rotterdam, the Erasmus University Rotterdam, the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research, and the Dutch Ministry of Health, Welfare and Sport, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond. This study was funded by a grantfromthe Netherlands organization for Health Research and Development (85500036) . Henning Tiemeier was sup-ported by a grant of the Netherlands Organization for Scientific Research (NWO/ZonMW grant 016.VICI.170.200) and of Erasmus Medical Center Efficiency Grant (MRC-2013-169) .
Published: 2022

5. Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in preadolescents

Author: Cabré Riera, Alba, Van Wel, Luuk, Liorni, Ilaria, Koopman Verhoeff, M. Elisabeth, Imaz, Liher, Ibarluzea Maurolagoitia, Jesús María, Huss, Anke, Wiart, Joe, Vermeulen, Roel, Joseph, Wout, Capstick, Myles, Vrijheid, Martine, Cardis, Elisabeth, Röösli, Martin, Eeftens, Marloes, Thielens, Arno, Tiemeier, Henning, Guxens, Mónica, Cabré Riera, Alba, Van Wel, Luuk, Liorni, Ilaria, Koopman Verhoeff, M. Elisabeth, Imaz, Liher, Ibarluzea Maurolagoitia, Jesús María, Huss, Anke, Wiart, Joe, Vermeulen, Roel, Joseph, Wout, Capstick, Myles, Vrijheid, Martine, Cardis, Elisabeth, Röösli, Martin, Eeftens, Marloes, Thielens, Arno, Tiemeier, Henning, and Guxens, Mónica
Abstract: [EN] Objective: To investigate the association of estimated all-day and evening whole-brain radiofrequency electromagnetic field (RF-EMF) doses with sleep disturbances and objective sleep measures in preadolescents. Methods: We included preadolescents aged 9-12 years from two population-based birth cohorts, the Dutch Generation R Study (n = 974) and the Spanish INfancia y Medio Ambiente Project (n = 868). All-day and evening overall whole-brain RF-EMF doses (mJ/kg/day) were estimated for several RF-EMF sources including mobile and Digital Enhanced Cordless Telecommunications (DECT) phone calls (named phone calls), other mobile phone uses, tablet use, laptop use (named screen activities), and far-field sources. We also estimated all-day and evening whole-brain RF-EMF doses in these three groups separately (i.e. phone calls, screen activities, and far-field). The Sleep Disturbance Scale for Children was completed by mothers to assess sleep disturbances. Wrist accelerometers together with sleep diaries were used to measure sleep characteristics objectively for 7 consecutive days. Results: All-day whole-brain RF-EMF doses were not associated with self-reported sleep disturbances and objective sleep measures. Regarding evening doses, preadolescents with high evening whole-brain RF-EMF dose from phone calls had a shorter total sleep time compared to preadolescents with zero evening whole-brain RF-EMF dose from phone calls [-11.9 min (95%CI -21.2; -2.5)]. Conclusions: Our findings suggest the evening as a potentially relevant window of RF-EMF exposure for sleep. However, we cannot exclude that observed associations are due to the activities or reasons motivating the phone calls rather than the RF-EMF exposure itself or due to chance finding.
Published: 2022

6. Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in preadolescents

Author: One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Cabré-Riera, Alba, van Wel, Luuk, Liorni, Ilaria, Koopman-Verhoeff, M Elisabeth, Imaz, Liher, Ibarluzea, Jesús, Huss, Anke, Wiart, Joe, Vermeulen, Roel, Joseph, Wout, Capstick, Myles, Vrijheid, Martine, Cardis, Elisabeth, Röösli, Martin, Eeftens, Marloes, Thielens, Arno, Tiemeier, Henning, Guxens, Mònica, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Cabré-Riera, Alba, van Wel, Luuk, Liorni, Ilaria, Koopman-Verhoeff, M Elisabeth, Imaz, Liher, Ibarluzea, Jesús, Huss, Anke, Wiart, Joe, Vermeulen, Roel, Joseph, Wout, Capstick, Myles, Vrijheid, Martine, Cardis, Elisabeth, Röösli, Martin, Eeftens, Marloes, Thielens, Arno, Tiemeier, Henning, and Guxens, Mònica
Published: 2022

7. Circulating Isovalerylcarnitine and Lung Cancer Risk : evidence from Mendelian Randomization and Prediagnostic Blood Measurements

Author: Smith-Byrne, Karl, Cerani, Agustin, Guida, Florence, Zhou, Sirui, Agudo, Antonio, Aleksandrova, Krasimira, Barricarte, Aurelio, Barranco, Miguel Rodríguez, Bochers, Christoph H., Gram, Inger Torhild, Han, Jun, Amos, Christopher I., Hung, Rayjean J., Grankvist, Kjell, Nøst, Therese Haugdhal, Imaz, Liher, Chirlaque-López, María Dolores, Johansson, Mikael, Kaaks, Rudolf, Kühn, Tilman, Martin, Richard M., McKay, James D., Pala, Valeria, Robbins, Hilary A., Sandanger, Torkjel M., Schibli, David, Schulze, Matthias B., Travis, Ruth C., Vineis, Paolo, Weiderpass, Elisabete, Brennan, Paul, Johansson, Mattias, Richards, J Brent, Smith-Byrne, Karl, Cerani, Agustin, Guida, Florence, Zhou, Sirui, Agudo, Antonio, Aleksandrova, Krasimira, Barricarte, Aurelio, Barranco, Miguel Rodríguez, Bochers, Christoph H., Gram, Inger Torhild, Han, Jun, Amos, Christopher I., Hung, Rayjean J., Grankvist, Kjell, Nøst, Therese Haugdhal, Imaz, Liher, Chirlaque-López, María Dolores, Johansson, Mikael, Kaaks, Rudolf, Kühn, Tilman, Martin, Richard M., McKay, James D., Pala, Valeria, Robbins, Hilary A., Sandanger, Torkjel M., Schibli, David, Schulze, Matthias B., Travis, Ruth C., Vineis, Paolo, Weiderpass, Elisabete, Brennan, Paul, Johansson, Mattias, and Richards, J Brent
Abstract: BACKGROUND: Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies. MATERIALS AND METHODS: We used Mendelian randomization (MR) to screen 207 metabolites for their role in lung cancer predisposition using independent genome-wide association studies (GWAS) of blood metabolite levels (n = 7,824) and lung cancer risk (n = 29,266 cases/56,450 controls). A nested case-control study (656 cases and 1,296 matched controls) was subsequently performed using prediagnostic blood samples to validate MR association with lung cancer incidence data from population-based cohorts (EPIC and NSHDS). RESULTS: An MR-based scan of 207 circulating metabolites for lung cancer risk identified that blood isovalerylcarnitine (IVC) was associated with a decreased odds of lung cancer after accounting for multiple testing (log10-OR = 0.43; 95% CI, 0.29-0.63). Molar measurement of IVC in prediagnostic blood found similar results (log10-OR = 0.39; 95% CI, 0.21-0.72). Results were consistent across lung cancer subtypes. CONCLUSIONS: Independent lines of evidence support an inverse association of elevated circulating IVC with lung cancer risk through a novel methodologic approach that integrates genetic and traditional epidemiology to efficiently identify novel cancer biomarkers. IMPACT: Our results find compelling evidence in favor of a protective role for a circulating metabolite, IVC, in lung cancer etiology. From the treatment of a Mendelian disease, isovaleric acidemia, we know that circulating IVC is modifiable through a restricted protein diet or glycine and L-carnatine supplementation. IVC may represent a modifiable and inversely associated biomarker for lung cancer.
Published: 2022
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8. Genetically Determined Reproductive Aging and Coronary Heart Disease : A Bidirectional 2-sample Mendelian Randomization

Author: Dam, Veerle, Onland-Moret, N. Charlotte, Burgess, Stephen, Chirlaque, Maria-Dolores, Peters, Sanne A. E, Schuit, Ewoud, Tikk, Kaja, Weiderpass, Elisabete, Oliver-Williams, Clare, Wood, Angela M, Tjønneland, Anne, Dahm, Christina C, Overvad, Kim, Boutron-Ruault, Marie-Christine, Schulze, Matthias B, Trichopoulou, Antonia, Ferrari, Pietro, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Matullo, Giuseppe, Panico, Salvatore, Boer, Jolanda M. A, Verschuren, W. M. Monique, Waaseth, Marit, PCrossed D sign©rez, Maria JosCrossed D sign© Sánchez, Amiano, Pilar, Imaz, Liher, Moreno-Iribas, Conchi, Melander, Olle, Harlid, Sophia, Nordendahl, Maria, Wennberg, Patrik, Key, Timothy J, Riboli, Elio, Santiuste, Carmen, Kaaks, Rudolf, Katzke, Verena, Langenberg, Claudia, Wareham, Nicholas J, Schunkert, Heribert, Erdmann, Jeanette, Willenborg, Christina, Hengstenberg, Christian, Kleber, Marcus E, Delgado, Graciela, März, Winfried, Kanoni, Stavroula, Dedoussis, George, Deloukas, Panos, Nikpay, Majid, Mcpherson, Ruth, Scholz, Markus, Teren, Andrej, Butterworth, Adam S, Van Der Schouw, Yvonne T, Dam, Veerle, Onland-Moret, N. Charlotte, Burgess, Stephen, Chirlaque, Maria-Dolores, Peters, Sanne A. E, Schuit, Ewoud, Tikk, Kaja, Weiderpass, Elisabete, Oliver-Williams, Clare, Wood, Angela M, Tjønneland, Anne, Dahm, Christina C, Overvad, Kim, Boutron-Ruault, Marie-Christine, Schulze, Matthias B, Trichopoulou, Antonia, Ferrari, Pietro, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Matullo, Giuseppe, Panico, Salvatore, Boer, Jolanda M. A, Verschuren, W. M. Monique, Waaseth, Marit, PCrossed D sign©rez, Maria JosCrossed D sign© Sánchez, Amiano, Pilar, Imaz, Liher, Moreno-Iribas, Conchi, Melander, Olle, Harlid, Sophia, Nordendahl, Maria, Wennberg, Patrik, Key, Timothy J, Riboli, Elio, Santiuste, Carmen, Kaaks, Rudolf, Katzke, Verena, Langenberg, Claudia, Wareham, Nicholas J, Schunkert, Heribert, Erdmann, Jeanette, Willenborg, Christina, Hengstenberg, Christian, Kleber, Marcus E, Delgado, Graciela, März, Winfried, Kanoni, Stavroula, Dedoussis, George, Deloukas, Panos, Nikpay, Majid, Mcpherson, Ruth, Scholz, Markus, Teren, Andrej, Butterworth, Adam S, and Van Der Schouw, Yvonne T
Abstract: Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Design: Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Participants: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. Main Outcome Measures: CHD, CHD risk factors, and ANM. Results: Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Conclusion: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.
Published: 2022
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9. Genetically determined reproductive aging and coronary heart disease:a bidirectional two-sample Mendelian Randomization

Author: Dam, Veerle, Onland-Moret, N Charlotte, Burgess, Stephen, Chirlaque, Maria-Dolores, Peters, Sanne A E, Schuit, Ewoud, Tikk, Kaja, Weiderpass, Elisabete, Oliver-Williams, Clare, Wood, Angela M, Tjønneland, Anne, Dahm, Christina C, Overvad, Kim, Boutron-Ruault, Marie-Christine, Schulze, Matthias B, Trichopoulou, Antonia, Ferrari, Pietro, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Matullo, Giuseppe, Panico, Salvatore, Boer, Jolanda M A, Verschuren, W M Monique, Waaseth, Marit, Sánchez Pérez, Maria José, Amiano, Pilar, Imaz, Liher, Moreno-Iribas, Conchi, Melander, Olle, Harlid, Sophia, Nordendahl, Maria, Wennberg, Patrik, Key, Timothy J, Riboli, Elio, Santiuste, Carmen, Kaaks, Rudolf, Katzke, Verena, Langenberg, Claudia, Wareham, Nicholas J, Schunkert, Heribert, Erdmann, Jeanette, Willenborg, Christina, Hengstenberg, Christian, Kleber, Marcus E, Delgado, Graciela, März, Winfried, Kanoni, Stavroula, Dedoussis, George, Deloukas, Panos, Nikpay, Majid, McPherson, Ruth, Scholz, Markus, Teren, Andrej, Butterworth, Adam S, van der Schouw, Yvonne T, Dam, Veerle, Onland-Moret, N Charlotte, Burgess, Stephen, Chirlaque, Maria-Dolores, Peters, Sanne A E, Schuit, Ewoud, Tikk, Kaja, Weiderpass, Elisabete, Oliver-Williams, Clare, Wood, Angela M, Tjønneland, Anne, Dahm, Christina C, Overvad, Kim, Boutron-Ruault, Marie-Christine, Schulze, Matthias B, Trichopoulou, Antonia, Ferrari, Pietro, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Matullo, Giuseppe, Panico, Salvatore, Boer, Jolanda M A, Verschuren, W M Monique, Waaseth, Marit, Sánchez Pérez, Maria José, Amiano, Pilar, Imaz, Liher, Moreno-Iribas, Conchi, Melander, Olle, Harlid, Sophia, Nordendahl, Maria, Wennberg, Patrik, Key, Timothy J, Riboli, Elio, Santiuste, Carmen, Kaaks, Rudolf, Katzke, Verena, Langenberg, Claudia, Wareham, Nicholas J, Schunkert, Heribert, Erdmann, Jeanette, Willenborg, Christina, Hengstenberg, Christian, Kleber, Marcus E, Delgado, Graciela, März, Winfried, Kanoni, Stavroula, Dedoussis, George, Deloukas, Panos, Nikpay, Majid, McPherson, Ruth, Scholz, Markus, Teren, Andrej, Butterworth, Adam S, and van der Schouw, Yvonne T
Abstract: BACKGROUND: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause.OBJECTIVES: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian Randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men.DESIGN: Two-sample MR, using both cohort data as well as summary statistics, with four methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression.PARTICIPANTS: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available GWAS were pooled for the different analyses.MAIN OUTCOME MEASURES: CHD, CHD risk factors and ANM.RESULTS: Across different methods of MR no association was found between genetically determined reproductive aging and CHD risk in women (Relative Risk Estimate (RRE)IVW=0.99, 95% confidence interval (CI):0.97;1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging.CONCLUSION: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.
Published: 2022

10. Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization: A Bidirectional 2-sample Mendelian Randomization

Author: Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 3, Global Health, Epi Methoden Team 4, JC onderzoeksprogramma Methodology, Public Health Practice, Dam, Veerle, Onland-Moret, N Charlotte, Burgess, Stephen, Chirlaque, Maria-Dolores, Peters, Sanne A E, Schuit, Ewoud, Tikk, Kaja, Weiderpass, Elisabete, Oliver-Williams, Clare, Wood, Angela M, Tjønneland, Anne, Dahm, Christina C, Overvad, Kim, Boutron-Ruault, Marie-Christine, Schulze, Matthias B, Trichopoulou, Antonia, Ferrari, Pietro, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Matullo, Giuseppe, Panico, Salvatore, Boer, Jolanda M A, Verschuren, W M Monique, Waaseth, Marit, Sánchez Pérez, Maria José, Amiano, Pilar, Imaz, Liher, Moreno-Iribas, Conchi, Melander, Olle, Harlid, Sophia, Nordendahl, Maria, Wennberg, Patrik, Key, Timothy J, Riboli, Elio, Santiuste, Carmen, Kaaks, Rudolf, Katzke, Verena, Langenberg, Claudia, Wareham, Nicholas J, Schunkert, Heribert, Erdmann, Jeanette, Willenborg, Christina, Hengstenberg, Christian, Kleber, Marcus E, Delgado, Graciela, März, Winfried, Kanoni, Stavroula, Dedoussis, George, Deloukas, Panos, Nikpay, Majid, McPherson, Ruth, Scholz, Markus, Teren, Andrej, Butterworth, Adam S, van der Schouw, Yvonne T, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 3, Global Health, Epi Methoden Team 4, JC onderzoeksprogramma Methodology, Public Health Practice, Dam, Veerle, Onland-Moret, N Charlotte, Burgess, Stephen, Chirlaque, Maria-Dolores, Peters, Sanne A E, Schuit, Ewoud, Tikk, Kaja, Weiderpass, Elisabete, Oliver-Williams, Clare, Wood, Angela M, Tjønneland, Anne, Dahm, Christina C, Overvad, Kim, Boutron-Ruault, Marie-Christine, Schulze, Matthias B, Trichopoulou, Antonia, Ferrari, Pietro, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Matullo, Giuseppe, Panico, Salvatore, Boer, Jolanda M A, Verschuren, W M Monique, Waaseth, Marit, Sánchez Pérez, Maria José, Amiano, Pilar, Imaz, Liher, Moreno-Iribas, Conchi, Melander, Olle, Harlid, Sophia, Nordendahl, Maria, Wennberg, Patrik, Key, Timothy J, Riboli, Elio, Santiuste, Carmen, Kaaks, Rudolf, Katzke, Verena, Langenberg, Claudia, Wareham, Nicholas J, Schunkert, Heribert, Erdmann, Jeanette, Willenborg, Christina, Hengstenberg, Christian, Kleber, Marcus E, Delgado, Graciela, März, Winfried, Kanoni, Stavroula, Dedoussis, George, Deloukas, Panos, Nikpay, Majid, McPherson, Ruth, Scholz, Markus, Teren, Andrej, Butterworth, Adam S, and van der Schouw, Yvonne T
Published: 2022

11. Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization

Author: Dam, Veerle, primary, Onland-Moret, N Charlotte, additional, Burgess, Stephen, additional, Chirlaque, Maria-Dolores, additional, Peters, Sanne A E, additional, Schuit, Ewoud, additional, Tikk, Kaja, additional, Weiderpass, Elisabete, additional, Oliver-Williams, Clare, additional, Wood, Angela M, additional, Tjønneland, Anne, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Schulze, Matthias B, additional, Trichopoulou, Antonia, additional, Ferrari, Pietro, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Tumino, Rosario, additional, Matullo, Giuseppe, additional, Panico, Salvatore, additional, Boer, Jolanda M A, additional, Verschuren, W M Monique, additional, Waaseth, Marit, additional, Pérez, Maria José Sánchez, additional, Amiano, Pilar, additional, Imaz, Liher, additional, Moreno-Iribas, Conchi, additional, Melander, Olle, additional, Harlid, Sophia, additional, Nordendahl, Maria, additional, Wennberg, Patrik, additional, Key, Timothy J, additional, Riboli, Elio, additional, Santiuste, Carmen, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Langenberg, Claudia, additional, Wareham, Nicholas J, additional, Schunkert, Heribert, additional, Erdmann, Jeanette, additional, Willenborg, Christina, additional, Hengstenberg, Christian, additional, Kleber, Marcus E, additional, Delgado, Graciela, additional, März, Winfried, additional, Kanoni, Stavroula, additional, Dedoussis, George, additional, Deloukas, Panos, additional, Nikpay, Majid, additional, McPherson, Ruth, additional, Scholz, Markus, additional, Teren, Andrej, additional, Butterworth, Adam S, additional, and van der Schouw, Yvonne T, additional
Published: 2022
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12. RETRACTED: Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author: Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, José Sánchez, María, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, Ferrari, Pietro, Clarke, Robert, Boutron, Marie-Christine, Severi, Gianluca, MacDonald, Conor, Providencia, Rui, Masala, Giovanna, Zamora Ros, Raul, Boer, Jolanda, Verschuren, WM Monique, Cawthon, Peggy, Schierbeck, Louise L, Cooper, Cyrus, Schulze, Matthias B, Bergmann, Manuela M, Hannemann, Anke, Kiechl, Stefan, Brenner, Hermann, van Schoor, Natasja M, Albertorio, Juan R, Sacerdote, Carlotta, Linneberg, Allan, Kårhus, Line L, Huerta, José María, Imaz, Liher, Joergensen, Christel, Ben-Shlomo, Yoav, Lundqvist, Annamari, Gallacher, John, Sattar, Naveed, Wood, Angela M, Wareham, Nicholas J, Nordestgaard, Børge G, Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S, and Burgess, Stephen
Published: 2021
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13. Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC‐CVD Case‐Cohort Study Across Nine European Countries

Author: Steur, Marinka, primary, Johnson, Laura, additional, Sharp, Stephen J., additional, Imamura, Fumiaki, additional, Sluijs, Ivonne, additional, Key, Timothy J., additional, Wood, Angela, additional, Chowdhury, Rajiv, additional, Guevara, Marcela, additional, Jakobsen, Marianne U., additional, Johansson, Ingegerd, additional, Koulman, Albert, additional, Overvad, Kim, additional, Sánchez, Maria‐José, additional, van der Schouw, Yvonne T., additional, Trichopoulou, Antonia, additional, Weiderpass, Elisabete, additional, Wennberg, Maria, additional, Zheng, Ju‐Sheng, additional, Boeing, Heiner, additional, Boer, Jolanda M. A., additional, Boutron‐Ruault, Marie‐Christine, additional, Ericson, Ulrika, additional, Heath, Alicia K., additional, Huybrechts, Inge, additional, Imaz, Liher, additional, Kaaks, Rudolf, additional, Krogh, Vittorio, additional, Kühn, Tilman, additional, Kyrø, Cecilie, additional, Masala, Giovanna, additional, Melander, Olle, additional, Moreno‐Iribas, Conchi, additional, Panico, Salvatore, additional, Quirós, José R., additional, Rodríguez‐Barranco, Miguel, additional, Sacerdote, Carlotta, additional, Santiuste, Carmen, additional, Skeie, Guri, additional, Tjønneland, Anne, additional, Tumino, Rosario, additional, Verschuren, W. M. Monique, additional, Zamora‐Ros, Raul, additional, Dahm, Christina C., additional, Perez‐Cornago, Aurora, additional, Schulze, Matthias B., additional, Tong, Tammy Y. N., additional, Riboli, Elio, additional, Wareham, Nicholas J., additional, Danesh, John, additional, Butterworth, Adam S., additional, and Forouhi, Nita G., additional
Published: 2021
Full Text: View/download PDF

14. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author: Sofianopoulou, Eleni, primary, Kaptoge, Stephen K, additional, Afzal, Shoaib, additional, Jiang, Tao, additional, Gill, Dipender, additional, Gundersen, Thomas E, additional, Bolton, Thomas R, additional, Allara, Elias, additional, Arnold, Matthew G, additional, Mason, Amy M, additional, Chung, Ryan, additional, Pennells, Lisa A M, additional, Shi, Fanchao, additional, Sun, Luanluan, additional, Willeit, Peter, additional, Forouhi, Nita G, additional, Langenberg, Claudia, additional, Sharp, Stephen J, additional, Panico, Salvatore, additional, Engström, Gunnar, additional, Melander, Olle, additional, Tong, Tammy Y N, additional, Perez-Cornago, Aurora, additional, Norberg, Margareta, additional, Johansson, Ingegerd, additional, Katzke, Verena, additional, Srour, Bernard, additional, José Sánchez, María, additional, Redondo-Sánchez, Daniel, additional, Olsen, Anja, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Brustad, Magritt, additional, Skeie, Guri, additional, Moreno-Iribas, Conchi, additional, Onland-Moret, N Charlotte, additional, van der Schouw, Yvonne T, additional, Tsilidis, Konstantinos K, additional, Heath, Alicia K, additional, Agnoli, Claudia, additional, Krogh, Vittorio, additional, de Boer, Ian H, additional, Kobylecki, Camilla Jannie, additional, Çolak, Yunus, additional, Zittermann, Armin, additional, Sundström, Johan, additional, Welsh, Paul, additional, Weiderpass, Elisabete, additional, Aglago, Elom K, additional, Ferrari, Pietro, additional, Clarke, Robert, additional, Boutron, Marie-Christine, additional, Severi, Gianluca, additional, MacDonald, Conor, additional, Providencia, Rui, additional, Masala, Giovanna, additional, Zamora Ros, Raul, additional, Boer, Jolanda, additional, Verschuren, WM Monique, additional, Cawthon, Peggy, additional, Schierbeck, Louise L, additional, Cooper, Cyrus, additional, Schulze, Matthias B, additional, Bergmann, Manuela M, additional, Hannemann, Anke, additional, Kiechl, Stefan, additional, Brenner, Hermann, additional, van Schoor, Natasja M, additional, Albertorio, Juan R, additional, Sacerdote, Carlotta, additional, Linneberg, Allan, additional, Kårhus, Line L, additional, Huerta, José María, additional, Imaz, Liher, additional, Joergensen, Christel, additional, Ben-Shlomo, Yoav, additional, Lundqvist, Annamari, additional, Gallacher, John, additional, Sattar, Naveed, additional, Wood, Angela M, additional, Wareham, Nicholas J, additional, Nordestgaard, Børge G, additional, Di Angelantonio, Emanuele, additional, Danesh, John, additional, Butterworth, Adam S, additional, and Burgess, Stephen, additional
Published: 2021
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15. Correction: Santa-Marina et al. Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA-INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study. Int. J. Environ. Res. Public Health 2020, 17, 7704

Author: Santa-Marina, Loreto, primary, Lertxundi, Nerea, additional, Andiarena, Ainara, additional, Irizar, Amaia, additional, Sunyer, Jordi, additional, Molinuevo, Amaia, additional, Llop, Sabrina, additional, Julvez, Jordi, additional, Beneito, Andrea, additional, Ibarluzea, Jesús, additional, Imaz, Liher, additional, and Ferrin, Maite, additional
Published: 2021
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16. Genetic architectures of proximal and distal colorectal cancer are partly distinct

Author: Huyghe, Jeroen R. Harrison, Tabitha A. Bien, Stephanie A. and Hampel, Heather Figueiredo, Jane C. Schmit, Stephanie L. and Conti, V, David Chen, Sai Qu, Conghui Lin, Yi Barfield, Richard Baron, John A. Cross, Amanda J. Diergaarde, Brenda and Duggan, David Harlid, Sophia Imaz, Liher Kang, Hyun Min and Levine, David M. Perduca, Vittorio Perez-Cornago, Aurora and Sakoda, Lori C. Schumacher, Fredrick R. Slattery, Martha L. and Toland, Amanda E. van Duijnhoven, Franzel J. B. Van Guelpen, Bethany Agudo, Antonio Albanes, Demetrius Alonso, M. Henar and Anderson, Kristin Arnau-Collell, Coral Arndt, Volker and Banbury, Barbara L. Bassik, Michael C. Berndt, I, Sonja and Bezieau, Stephane Bishop, D. Timothy Boehm, Juergen Boeing, Heiner Boutron-Ruault, Marie-Christine Brenner, Hermann and Brezina, Stefanie Buch, Stephan Buchanan, Daniel D. and Burnett-Hartman, Andrea Caan, Bette J. Campbell, Peter T. and Carr, Prudence R. Castells, Antoni Castellvi-Bel, Sergi and Chan, Andrew T. Chang-Claude, Jenny Chanock, Stephen J. and Curtis, Keith R. de la Chapelle, Albert Easton, Douglas F. and English, Dallas R. Feskens, Edith J. M. Gala, Manish and Gallinger, Steven J. Gauderman, W. James Giles, Graham G. and Goodman, Phyllis J. Grady, William M. Grove, John S. Gsur, Andrea Gunter, Marc J. Haile, Robert W. Hampe, Jochen and Hoffmeister, Michael Hopper, John L. Hsu, Wan-Ling Huang, Wen-Yi Hudson, Thomas J. Jenab, Mazda Jenkins, Mark A. and Joshi, Amit D. Keku, Temitope O. Kooperberg, Charles Kuhn, Tilman Kury, Sebastien Le Marchand, Loic Lejbkowicz, Flavio and Li, I, Christopher Li, Li Lieb, Wolfgang Lindblom, Annika Lindor, Noralane M. Mannisto, Satu Markowitz, Sanford D. Milne, Roger L. Moreno, Lorena Murphy, Neil Nassir, Rami Offit, Kenneth Ogino, Shuji Panico, Salvatore and Parfrey, Patrick S. Pearlman, Rachel Pharoah, Paul D. P. and Phipps, I, Amanda Platz, Elizabeth A. Potter, John D. and Prentice, Ross L. Qi, Lihong Raskin, Leon Rennert, Gad and Rennert, Hedy S. Riboli, Elio Schafmayer, Clemens Schoen, Robert E. Seminara, Daniela Song, Mingyang Su, Yu-Ru and Tangen, Catherine M. Thibodeau, Stephen N. Thomas, Duncan C. and Trichopoulou, Antonia Ulrich, Cornelia M. Visvanathan, Kala and Vodicka, Pavel Vodickova, Ludmila Vymetalkova, Veronika and Weigl, Korbinian Weinstein, Stephanie J. White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Abecasis, Goncalo R. and Nickerson, Deborah A. Scacheri, Peter C. Kundaje, Anshul and Casey, Graham Gruber, Stephen B. Hsu, Li Moreno, Victor and Hayes, Richard B. Newcomb, Polly A. Peters, Ulrike
Subjects: digestive system diseases
Abstract: Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined. Design To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling. Results We identified 13 loci that reached genome-wide significance (p
Published: 2021

17. Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease : Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries

Author: Steur, Marinka, Johnson, Laura, Sharp, Stephen J, Imamura, Fumiaki, Sluijs, Ivonne, Key, Timothy J, Wood, Angela, Chowdhury, Rajiv, Guevara, Marcela, Jakobsen, Marianne U, Johansson, Ingegerd, Koulman, Albert, Overvad, Kim, Sánchez, Maria-José, van der Schouw, Yvonne T, Trichopoulou, Antonia, Weiderpass, Elisabete, Wennberg, Maria, Zheng, Ju-Sheng, Boeing, Heiner, Boer, Jolanda M A, Boutron-Ruault, Marie-Christine, Ericson, Ulrika, Heath, Alicia K, Huybrechts, Inge, Imaz, Liher, Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kyrø, Cecilie, Masala, Giovanna, Melander, Olle, Moreno-Iribas, Conchi, Panico, Salvatore, Quirós, José R, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Santiuste, Carmen, Skeie, Guri, Tjønneland, Anne, Tumino, Rosario, Verschuren, W M Monique, Zamora-Ros, Raul, Dahm, Christina C, Perez-Cornago, Aurora, Schulze, Matthias B, Tong, Tammy Y N, Riboli, Elio, Wareham, Nicholas J, Danesh, John, Butterworth, Adam S, Forouhi, Nita G, Steur, Marinka, Johnson, Laura, Sharp, Stephen J, Imamura, Fumiaki, Sluijs, Ivonne, Key, Timothy J, Wood, Angela, Chowdhury, Rajiv, Guevara, Marcela, Jakobsen, Marianne U, Johansson, Ingegerd, Koulman, Albert, Overvad, Kim, Sánchez, Maria-José, van der Schouw, Yvonne T, Trichopoulou, Antonia, Weiderpass, Elisabete, Wennberg, Maria, Zheng, Ju-Sheng, Boeing, Heiner, Boer, Jolanda M A, Boutron-Ruault, Marie-Christine, Ericson, Ulrika, Heath, Alicia K, Huybrechts, Inge, Imaz, Liher, Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kyrø, Cecilie, Masala, Giovanna, Melander, Olle, Moreno-Iribas, Conchi, Panico, Salvatore, Quirós, José R, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Santiuste, Carmen, Skeie, Guri, Tjønneland, Anne, Tumino, Rosario, Verschuren, W M Monique, Zamora-Ros, Raul, Dahm, Christina C, Perez-Cornago, Aurora, Schulze, Matthias B, Tong, Tammy Y N, Riboli, Elio, Wareham, Nicholas J, Danesh, John, Butterworth, Adam S, and Forouhi, Nita G
Abstract: Background: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. Methods and Results: We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88-0.99]), cheese (HR, 0.98 [95% CI, 0.96-1.00]), and fish (HR, 0.87 [95% CI, 0.75-1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02-1.12]) and butter (HR, 1.02 [95% CI, 1.00-1.04]). Conclusions: This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite directions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.
Published: 2021
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18. Genetic architectures of proximal and distal colorectal cancer are partly distinct

Author: Huyghe, Jeroen R, Harrison, Tabitha A, Bien, Stephanie A, Hampel, Heather, Figueiredo, Jane C, Schmit, Stephanie L, Conti, David V, Chen, Sai, Qu, Conghui, Lin, Yi, Barfield, Richard, Baron, John A, Cross, Amanda J, Diergaarde, Brenda, Duggan, David, Harlid, Sophia, Imaz, Liher, Kang, Hyun Min, Levine, David M, Perduca, Vittorio, Perez-Cornago, Aurora, Sakoda, Lori C, Schumacher, Fredrick R, Slattery, Martha L, Toland, Amanda E, van Duijnhoven, Fränzel J B, Van Guelpen, Bethany, Agudo, Antonio, Albanes, Demetrius, Alonso, M Henar, Anderson, Kristin, Arnau-Collell, Coral, Arndt, Volker, Banbury, Barbara L, Bassik, Michael C, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Boehm, Juergen, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Brenner, Hermann, Brezina, Stefanie, Buch, Stephan, Buchanan, Daniel D, Burnett-Hartman, Andrea, Caan, Bette J, Campbell, Peter T, Carr, Prudence R, Castells, Antoni, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Curtis, Keith R, de la Chapelle, Albert, Easton, Douglas F, English, Dallas R, Feskens, Edith J M, Gala, Manish, Gallinger, Steven J, Gauderman, W James, Giles, Graham G, Goodman, Phyllis J, Grady, William M, Grove, John S, Gsur, Andrea, Gunter, Marc J, Haile, Robert W, Hampe, Jochen, Hoffmeister, Michael, Hopper, John L, Hsu, Wan-Ling, Huang, Wen-Yi, Hudson, Thomas J, Jenab, Mazda, Jenkins, Mark A, Joshi, Amit D, Keku, Temitope O, Kooperberg, Charles, Kühn, Tilman, Küry, Sébastien, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Christopher I, Li, Li, Lieb, Wolfgang, Lindblom, Annika, Lindor, Noralane M, Männistö, Satu, Markowitz, Sanford D, Milne, Roger L, Moreno, Lorena, Murphy, Neil, Nassir, Rami, Offit, Kenneth, Ogino, Shuji, Panico, Salvatore, Parfrey, Patrick S, Pearlman, Rachel, Pharoah, Paul D P, Phipps, Amanda I, Platz, Elizabeth A, Potter, John D, Prentice, Ross L, Qi, Lihong, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, Riboli, Elio, Schafmayer, Clemens, Schoen, Robert E, Seminara, Daniela, Song, Mingyang, Su, Yu-Ru, Tangen, Catherine M, Thibodeau, Stephen N, Thomas, Duncan C, Trichopoulou, Antonia, Ulrich, Cornelia M, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weigl, Korbinian, Weinstein, Stephanie J, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Abecasis, Goncalo R, Nickerson, Deborah A, Scacheri, Peter C, Kundaje, Anshul, Casey, Graham, Gruber, Stephen B, Hsu, Li, Moreno, Victor, Hayes, Richard B, Newcomb, Polly A, Peters, Ulrike, Huyghe, Jeroen R, Harrison, Tabitha A, Bien, Stephanie A, Hampel, Heather, Figueiredo, Jane C, Schmit, Stephanie L, Conti, David V, Chen, Sai, Qu, Conghui, Lin, Yi, Barfield, Richard, Baron, John A, Cross, Amanda J, Diergaarde, Brenda, Duggan, David, Harlid, Sophia, Imaz, Liher, Kang, Hyun Min, Levine, David M, Perduca, Vittorio, Perez-Cornago, Aurora, Sakoda, Lori C, Schumacher, Fredrick R, Slattery, Martha L, Toland, Amanda E, van Duijnhoven, Fränzel J B, Van Guelpen, Bethany, Agudo, Antonio, Albanes, Demetrius, Alonso, M Henar, Anderson, Kristin, Arnau-Collell, Coral, Arndt, Volker, Banbury, Barbara L, Bassik, Michael C, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Boehm, Juergen, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Brenner, Hermann, Brezina, Stefanie, Buch, Stephan, Buchanan, Daniel D, Burnett-Hartman, Andrea, Caan, Bette J, Campbell, Peter T, Carr, Prudence R, Castells, Antoni, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Curtis, Keith R, de la Chapelle, Albert, Easton, Douglas F, English, Dallas R, Feskens, Edith J M, Gala, Manish, Gallinger, Steven J, Gauderman, W James, Giles, Graham G, Goodman, Phyllis J, Grady, William M, Grove, John S, Gsur, Andrea, Gunter, Marc J, Haile, Robert W, Hampe, Jochen, Hoffmeister, Michael, Hopper, John L, Hsu, Wan-Ling, Huang, Wen-Yi, Hudson, Thomas J, Jenab, Mazda, Jenkins, Mark A, Joshi, Amit D, Keku, Temitope O, Kooperberg, Charles, Kühn, Tilman, Küry, Sébastien, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Christopher I, Li, Li, Lieb, Wolfgang, Lindblom, Annika, Lindor, Noralane M, Männistö, Satu, Markowitz, Sanford D, Milne, Roger L, Moreno, Lorena, Murphy, Neil, Nassir, Rami, Offit, Kenneth, Ogino, Shuji, Panico, Salvatore, Parfrey, Patrick S, Pearlman, Rachel, Pharoah, Paul D P, Phipps, Amanda I, Platz, Elizabeth A, Potter, John D, Prentice, Ross L, Qi, Lihong, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, Riboli, Elio, Schafmayer, Clemens, Schoen, Robert E, Seminara, Daniela, Song, Mingyang, Su, Yu-Ru, Tangen, Catherine M, Thibodeau, Stephen N, Thomas, Duncan C, Trichopoulou, Antonia, Ulrich, Cornelia M, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weigl, Korbinian, Weinstein, Stephanie J, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Abecasis, Goncalo R, Nickerson, Deborah A, Scacheri, Peter C, Kundaje, Anshul, Casey, Graham, Gruber, Stephen B, Hsu, Li, Moreno, Victor, Hayes, Richard B, Newcomb, Polly A, and Peters, Ulrike
Abstract: Objective: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined. Design: To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling. Results: We identified 13 loci that reached genome-wide significance (p<5×10-8) and that were not reported by previous GWASs for overall CRC risk. Multiple lines of evidence support candidate genes at several of these loci. We detected substantial heterogeneity between anatomical subsites. Just over half (61) of 109 known and new risk variants showed no evidence for heterogeneity. In contrast, 22 variants showed association with distal CRC (including rectal cancer), but no evidence for association or an attenuated association with proximal CRC. For two loci, there was strong evidence for effects confined to proximal colon cancer. Conclusion: Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour.
Published: 2021
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19. Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Perez-Cornago, Aurora, Crowe, Francesca L., Appleby, Paul N., Bradbury, Kathryn E., Wood, Angela M., Uhre Jakobsen, Marianne, Johnson, Laura, Sacerdote, Carlotta, Steur, Marinka, Weiderpass, Elisabete, Würtz, Anne Mette L., Kühn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Masala, Giovanna, Tumino, Rosario, Panico, Salvatore, Sluijs, Ivonne, Skeie, Guri, Imaz, Liher, Petrova, Dafina, Quirós, J. Ramón, Yohar, Sandra Milena Colorado, Jakszyn, Paula, Melander, Olle, Sonestedt, Emily, Andersson, Jonas, Wennberg, Maria, Aune, Dagfinn, Riboli, Elio, Schulze, Matthias B., di Angelantonio, Emanuele, Wareham, Nicholas J., Danesh, John, Forouhi, Nita G., Butterworth, Adam S., Key, Timothy J., Perez-Cornago, Aurora, Crowe, Francesca L., Appleby, Paul N., Bradbury, Kathryn E., Wood, Angela M., Uhre Jakobsen, Marianne, Johnson, Laura, Sacerdote, Carlotta, Steur, Marinka, Weiderpass, Elisabete, Würtz, Anne Mette L., Kühn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Masala, Giovanna, Tumino, Rosario, Panico, Salvatore, Sluijs, Ivonne, Skeie, Guri, Imaz, Liher, Petrova, Dafina, Quirós, J. Ramón, Yohar, Sandra Milena Colorado, Jakszyn, Paula, Melander, Olle, Sonestedt, Emily, Andersson, Jonas, Wennberg, Maria, Aune, Dagfinn, Riboli, Elio, Schulze, Matthias B., di Angelantonio, Emanuele, Wareham, Nicholas J., Danesh, John, Forouhi, Nita G., Butterworth, Adam S., and Key, Timothy J.
Abstract: Background: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD. Results: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90–0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95–1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82–0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85–0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91–0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95–1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk. Conclusions: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear.
Published: 2021
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20. Genetic architectures of proximal and distal colorectal cancer are partly distinct

Author: Huyghe, Jeroen R., Harrison, Tabitha A., Bien, Stephanie A., Hampel, Heather, Figueiredo, Jane C., Schmit, Stephanie L., Conti, David V., Chen, Sai, Qu, Conghui, Lin, Yi, Barfield, Richard, Baron, John A., Cross, Amanda J., Diergaarde, Brenda, Duggan, David, Harlid, Sophia, Imaz, Liher, Kang, Hyun Min, Levine, David M., Perduca, Vittorio, Perez-Cornago, Aurora, Sakoda, Lori C., Schumacher, Fredrick R., Slattery, Martha L., Toland, Amanda E., Van Duijnhoven, Fränzel J.B., Van Guelpen, Bethany, Agudo, Antonio, Albanes, Demetrius, Alonso, M.H., Anderson, Kristin, Arnau-Collell, Coral, Arndt, Volker, Banbury, Barbara L., Bassik, Michael C., Berndt, Sonja I., Bézieau, Stéphane, Bishop, D.T., Boehm, Juergen, Boeing, Heiner, Boutron-Ruault, Marie Christine, Brenner, Hermann, Brezina, Stefanie, Buch, Stephan, Buchanan, Daniel D., Burnett-Hartman, Andrea, Caan, Bette J., Campbell, Peter T., Carr, Prudence R., Castells, Antoni, Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Curtis, Keith R., De La Chapelle, Albert, Easton, Douglas F., English, Dallas R., Feskens, Edith J.M., Gala, Manish, Gallinger, Steven J., Gauderman, W.J., Giles, Graham G., Goodman, Phyllis J., Grady, William M., Grove, John S., Gsur, Andrea, Gunter, Marc J., Haile, Robert W., Hampe, Jochen, Hoffmeister, Michael, Hopper, John L., Hsu, Wan Ling, Huang, Wen Yi, Hudson, Thomas J., Jenab, Mazda, Jenkins, Mark A., Joshi, Amit D., Keku, Temitope O., Kooperberg, Charles, Kühn, Tilman, Küry, Sébastien, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Christopher I., Li, Li, Lieb, Wolfgang, Lindblom, Annika, Lindor, Noralane M., Männistö, Satu, Markowitz, Sanford D., Milne, Roger L., Moreno, Lorena, Murphy, Neil, Nassir, Rami, Offit, Kenneth, Ogino, Shuji, Panico, Salvatore, Parfrey, Patrick S., Pearlman, Rachel, Pharoah, Paul D.P., Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Prentice, Ross L., Qi, Lihong, Raskin, Leon, Rennert, Gad, Rennert, Hedy S., Riboli, Elio, Schafmayer, Clemens, Schoen, Robert E., Seminara, Daniela, Song, Mingyang, Su, Yu Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Trichopoulou, Antonia, Ulrich, Cornelia M., Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weigl, Korbinian, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Abecasis, Goncalo R., Nickerson, Deborah A., Scacheri, Peter C., Kundaje, Anshul, Casey, Graham, Gruber, Stephen B., Hsu, Li, Moreno, Victor, Hayes, Richard B., Newcomb, Polly A., Peters, Ulrike, Huyghe, Jeroen R., Harrison, Tabitha A., Bien, Stephanie A., Hampel, Heather, Figueiredo, Jane C., Schmit, Stephanie L., Conti, David V., Chen, Sai, Qu, Conghui, Lin, Yi, Barfield, Richard, Baron, John A., Cross, Amanda J., Diergaarde, Brenda, Duggan, David, Harlid, Sophia, Imaz, Liher, Kang, Hyun Min, Levine, David M., Perduca, Vittorio, Perez-Cornago, Aurora, Sakoda, Lori C., Schumacher, Fredrick R., Slattery, Martha L., Toland, Amanda E., Van Duijnhoven, Fränzel J.B., Van Guelpen, Bethany, Agudo, Antonio, Albanes, Demetrius, Alonso, M.H., Anderson, Kristin, Arnau-Collell, Coral, Arndt, Volker, Banbury, Barbara L., Bassik, Michael C., Berndt, Sonja I., Bézieau, Stéphane, Bishop, D.T., Boehm, Juergen, Boeing, Heiner, Boutron-Ruault, Marie Christine, Brenner, Hermann, Brezina, Stefanie, Buch, Stephan, Buchanan, Daniel D., Burnett-Hartman, Andrea, Caan, Bette J., Campbell, Peter T., Carr, Prudence R., Castells, Antoni, Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Curtis, Keith R., De La Chapelle, Albert, Easton, Douglas F., English, Dallas R., Feskens, Edith J.M., Gala, Manish, Gallinger, Steven J., Gauderman, W.J., Giles, Graham G., Goodman, Phyllis J., Grady, William M., Grove, John S., Gsur, Andrea, Gunter, Marc J., Haile, Robert W., Hampe, Jochen, Hoffmeister, Michael, Hopper, John L., Hsu, Wan Ling, Huang, Wen Yi, Hudson, Thomas J., Jenab, Mazda, Jenkins, Mark A., Joshi, Amit D., Keku, Temitope O., Kooperberg, Charles, Kühn, Tilman, Küry, Sébastien, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Christopher I., Li, Li, Lieb, Wolfgang, Lindblom, Annika, Lindor, Noralane M., Männistö, Satu, Markowitz, Sanford D., Milne, Roger L., Moreno, Lorena, Murphy, Neil, Nassir, Rami, Offit, Kenneth, Ogino, Shuji, Panico, Salvatore, Parfrey, Patrick S., Pearlman, Rachel, Pharoah, Paul D.P., Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Prentice, Ross L., Qi, Lihong, Raskin, Leon, Rennert, Gad, Rennert, Hedy S., Riboli, Elio, Schafmayer, Clemens, Schoen, Robert E., Seminara, Daniela, Song, Mingyang, Su, Yu Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Trichopoulou, Antonia, Ulrich, Cornelia M., Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weigl, Korbinian, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Abecasis, Goncalo R., Nickerson, Deborah A., Scacheri, Peter C., Kundaje, Anshul, Casey, Graham, Gruber, Stephen B., Hsu, Li, Moreno, Victor, Hayes, Richard B., Newcomb, Polly A., and Peters, Ulrike
Abstract: Objective: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined. Design: To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling. Results: We identified 13 loci that reached genome-wide significance (p<5×10-8) and that were not reported by previous GWASs for overall CRC risk. Multiple lines of evidence support candidate genes at several of these loci. We detected substantial heterogeneity between anatomical subsites. Just over half (61) of 109 known and new risk variants showed no evidence for heterogeneity. In contrast, 22 variants showed association with distal CRC (including rectal cancer), but no evidence for association or an attenuated association with proximal CRC. For two loci, there was strong evidence for effects confined to proximal colon cancer. Conclusion: Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour.
Published: 2021

21. Dietary fatty acids, macronutrient substitutions, food sources and incidence of coronary heart disease:Findings from the EPIC-CVD case-cohort study across nine european countries

Author: Steur, Marinka, Johnson, Laura, Sharp, Stephen J., Imamura, Fumiaki, Sluijs, Ivonne, Key, Timothy J., Wood, Angela, Chowdhury, Rajiv, Guevara, Marcela, Jakobsen, Marianne U., Johansson, Ingegerd, Koulman, Albert, Overvad, Kim, Sánchez, Maria José, van der Schouw, Yvonne T., Trichopoulou, Antonia, Weiderpass, Elisabete, Wennberg, Maria, Zheng, Ju Sheng, Boeing, Heiner, Boer, Jolanda M.A., Boutron-Ruault, Marie Christine, Ericson, Ulrika, Heath, Alicia K., Huybrechts, Inge, Imaz, Liher, Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kyrø, Cecilie, Masala, Giovanna, Melander, Olle, Moreno-Iribas, Conchi, Panico, Salvatore, Quirós, José R., Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Santiuste, Carmen, Skeie, Guri, Tjønneland, Anne, Tumino, Rosario, Monique Verschuren, W. M., Zamora-Ros, Raul, Dahm, Christina C., Perez-Cornago, Aurora, Schulze, Matthias B., Tong, Tammy Y.N., Riboli, Elio, Wareham, Nicholas J., Danesh, John, Butterworth, Adam S., Forouhi, Nita G., Steur, Marinka, Johnson, Laura, Sharp, Stephen J., Imamura, Fumiaki, Sluijs, Ivonne, Key, Timothy J., Wood, Angela, Chowdhury, Rajiv, Guevara, Marcela, Jakobsen, Marianne U., Johansson, Ingegerd, Koulman, Albert, Overvad, Kim, Sánchez, Maria José, van der Schouw, Yvonne T., Trichopoulou, Antonia, Weiderpass, Elisabete, Wennberg, Maria, Zheng, Ju Sheng, Boeing, Heiner, Boer, Jolanda M.A., Boutron-Ruault, Marie Christine, Ericson, Ulrika, Heath, Alicia K., Huybrechts, Inge, Imaz, Liher, Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kyrø, Cecilie, Masala, Giovanna, Melander, Olle, Moreno-Iribas, Conchi, Panico, Salvatore, Quirós, José R., Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Santiuste, Carmen, Skeie, Guri, Tjønneland, Anne, Tumino, Rosario, Monique Verschuren, W. M., Zamora-Ros, Raul, Dahm, Christina C., Perez-Cornago, Aurora, Schulze, Matthias B., Tong, Tammy Y.N., Riboli, Elio, Wareham, Nicholas J., Danesh, John, Butterworth, Adam S., and Forouhi, Nita G.
Abstract: BACKGROUND: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. METHODS AND RESULTS: We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88– 0.99]), cheese (HR, 0.98 [95% CI, 0.96–1.00]), and fish (HR, 0.87 [95% CI, 0.75–1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02–1.12]) and butter (HR, 1.02 [95% CI, 1.00–1.04]). CONCLUSIONS: This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite direc-tions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.
Published: 2021

22. High-density SNP genotyping detects homogeneity of Spanish and French Basques, and confirms their genomic distinctiveness from other European populations

Author: Rodríguez-Ezpeleta, Naiara, Álvarez-Busto, Jon, Imaz, Liher, Regueiro, María, Azcárate, María Nerea, Bilbao, Roberto, Iriondo, Mikel, Gil, Ana, Estonba, Andone, and Aransay, Ana María
Published: 2010
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23. sj-pdf-1-msc-10.1177_0969141320921893 - Supplemental material for Impact of an organised population screening programme for colorectal cancer: Measurement after first and second rounds

Author: Mar, Javier, Arrospide, Arantzazu, Larrañaga, Igor, Iruretagoiena, Maria Luisa, Imaz, Liher, Gorostiza, Ania, and Ibarrondo, Oliver
Subjects: 111708 Health and Community Services, FOS: Clinical medicine, 111402 Obstetrics and Gynaecology, FOS: Health sciences
Abstract: Supplemental material, sj-pdf-1-msc-10.1177_0969141320921893 for Impact of an organised population screening programme for colorectal cancer: Measurement after first and second rounds by Javier Mar, Arantzazu Arrospide, Igor Larrañaga, Maria Luisa Iruretagoiena, Liher Imaz, Ania Gorostiza and Oliver Ibarrondo: on behalf of the ETIS investigators* in Journal of Medical Screening
Published: 2020
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24. The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke : a prospective study of 418 329 participants in the EPIC cohort across nine European countries

Author: Tong, Tammy Y. N., Appleby, Paul N., Key, Timothy J., Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Katzke, Verena, Kuhn, Tilman, Boeing, Heiner, Karakatsani, Anna, Peppa, Eleni, Trichopoulou, Antonia, Weiderpass, Elisabete, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Boer, Jolanda M. A., Verschuren, W. M. Monique, Quiros, J. Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Imaz, Liher, Chirlaque, Maria-Dolores, Moreno-Iribas, Conchi, Engstrom, Gunnar, Sonestedt, Emily, Lind, Marcus, Otten, Julia, Khaw, Kay-Tee, Aune, Dagfinn, Riboli, Elio, Wareham, Nicholas J., Imamura, Fumiaki, Forouhi, Nita G., di Angelantonio, Emanuele, Wood, Angela M., Butterworth, Adam S., Perez-Cornago, Aurora, Tong, Tammy Y. N., Appleby, Paul N., Key, Timothy J., Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Katzke, Verena, Kuhn, Tilman, Boeing, Heiner, Karakatsani, Anna, Peppa, Eleni, Trichopoulou, Antonia, Weiderpass, Elisabete, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Boer, Jolanda M. A., Verschuren, W. M. Monique, Quiros, J. Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Imaz, Liher, Chirlaque, Maria-Dolores, Moreno-Iribas, Conchi, Engstrom, Gunnar, Sonestedt, Emily, Lind, Marcus, Otten, Julia, Khaw, Kay-Tee, Aune, Dagfinn, Riboli, Elio, Wareham, Nicholas J., Imamura, Fumiaki, Forouhi, Nita G., di Angelantonio, Emanuele, Wood, Angela M., Butterworth, Adam S., and Perez-Cornago, Aurora
Abstract: Aim: To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results: We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated using 24-h recalls. Multivariable-adjusted Cox regressions were used to estimate hazard ratios (HRs) for ischaemic and haemorrhagic stroke associated with consumption of red and processed meat, poultry, fish, dairy foods, eggs, cereals, fruit and vegetables, legumes, nuts and seeds, and dietary fibre. For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200 g/day higher intake, 0.87; 0.82–0.93, P-trend < 0.001), dietary fibre (per 10 g/day, 0.77; 0.69–0.86, P-trend < 0.001), milk (per 200 g/day, 0.95; 0.91–0.99, P-trend = 0.02), yogurt (per 100 g/day, 0.91; 0.85–0.97, P-trend = 0.004), and cheese (per 30 g/day, 0.88; 0.81–0.97, P-trend = 0.008), while higher risk was observed with higher red meat consumption which attenuated when adjusted for the other statistically significant foods (per 50 g/day, 1.07; 0.96–1.20, P-trend = 0.20). For haemorrhagic stroke (1430 cases), higher risk was associated with higher egg consumption (per 20 g/day, 1.25; 1.09–1.43, P-trend = 0.002). Conclusion: Risk of ischaemic stroke was inversely associated with consumption of fruit and vegetables, dietary fibre, and dairy foods, while risk of haemorrhagic stroke was positively associated with egg consumption. The apparent differences in the associations highlight the importance of examining ischaemic and haemorrhagic stroke subtypes separately.
Published: 2020
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25. Antibody Responses to Helicobacter pylori and Risk of Developing Colorectal Cancer in a European Cohort

Author: Butt, Julia, Jenab, Mazda, Pawlita, Michael, Tjonneland, Anne, Kyro, Cecilie, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Dong, Catherine, Kaaks, Rudolf, Kuhn, Tilman, Boeing, Heiner, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vermeulen, Roel, Gram, Inger T., Weiderpass, Elisabete, Borch, Kristin Benjaminsen, Quiros, Jose Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Santiuste, Carmen, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Imaz, Liher, Perez-Cornago, Aurora, Gunter, Marc J., Zouiouich, Semi, Park, Jin Young, Riboli, Elio, Cross, Amanda J., Heath, Alicia K., Waterboer, Tim, Hughes, David J., Butt, Julia, Jenab, Mazda, Pawlita, Michael, Tjonneland, Anne, Kyro, Cecilie, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Dong, Catherine, Kaaks, Rudolf, Kuhn, Tilman, Boeing, Heiner, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vermeulen, Roel, Gram, Inger T., Weiderpass, Elisabete, Borch, Kristin Benjaminsen, Quiros, Jose Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Santiuste, Carmen, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Imaz, Liher, Perez-Cornago, Aurora, Gunter, Marc J., Zouiouich, Semi, Park, Jin Young, Riboli, Elio, Cross, Amanda J., Heath, Alicia K., Waterboer, Tim, and Hughes, David J.
Abstract: Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific seropositivity with odds of developing colorectal cancer. Results: Fifty-one percent of colorectal cancer cases were H. pylori seropositive compared with 44% of controls, resulting in an OR of 1.36 (95% CI, 1.00-1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by seropositivity to Helicobacter cysteine-rich protein C (HcpC; OR: 1.66; 95% CI, 1.19-2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34; 95% CI, 0.99-1.82), the latter being nonstatistically significant only in the fully adjusted model. Conclusions: In this prospective multicenter European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing colorectal cancer. Impact: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease colorectal cancer incidence.
Published: 2020
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26. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Author: Li, Chen, Stoma, Svetlana, Lotta, Luca A., Warner, Sophie, Albrecht, Eva, Allione, Alessandra, Arp, Pascal P., Broer, Linda, Buxton, Jessica L., Da Silva Couto Alves, Alexessander, Deelen, Joris, Fedko, Iryna O., Gordon, Scott D., Jiang, Tao, Karlsson, Robert, Kerrison, Nicola, Loe, Taylor K., Mangino, Massimo, Milaneschi, Yuri, Miraglio, Benjamin, Pervjakova, Natalia, Russo, Alessia, Surakka, Ida, van der Spek, Ashley, Verhoeven, Josine E., Amin, Najaf, Beekman, Marian, Blakemore, Alexandra I., Canzian, Federico, Hamby, Stephen E., Hottenga, Jouke-Jan, Jones, Peter D., Jousilahti, Pekka, Mägi, Reedik, Medland, Sarah E., Montgomery, Grant W., Nyholt, Dale R., Perola, Markus, Pietiläinen, Kirsi H., Salomaa, Veikko, Sillanpää, Elina, Suchiman, H. Eka, van Heemst, Diana, Willemsen, Gonneke, Agudo, Antonio, Boeing, Heiner, Boomsma, Dorret I., Chirlaque, Maria-Dolores, Fagherazzi, Guy, Ferrari, Pietro, Franks, Paul W., Gieger, Christian, Eriksson, Johan Gunnar, Gunter, Marc, Hagg, Sara, Hovatta, Iiris, Imaz, Liher, Kaprio, Jaakko, Kaaks, Rudolf, Key, Timothy, Krogh, Vittorio, Martin, Nicholas G., Melander, Olle, Metspalu, Andres, Moreno, Concha, Onland-Moret, N. Charlotte, Nilsson, Peter, Ong, Ken K., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Pedersen, Nancy L., Penninx, Brenda W. J. H., Quirós, J. Ramón, Riitta Jarvelin, Marjo, Rodríguez-Barranco, Miguel, Scott, Robert A., Severi, Gianluca, Slagboom, P. Eline, Spector, Tim D., Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, Uitterlinden, André G., van der Schouw, Yvonne T., van Duijn, Cornelia M., Weiderpass, Elisabete, Denchi, Eros Lazzerini, Matullo, Giuseppe, Butterworth, Adam S., Danesh, John, Samani, Nilesh J., Wareham, Nicholas J., Nelson, Christopher P., Langenberg, Claudia, Codd, Veryan, Li, Chen, Stoma, Svetlana, Lotta, Luca A., Warner, Sophie, Albrecht, Eva, Allione, Alessandra, Arp, Pascal P., Broer, Linda, Buxton, Jessica L., Da Silva Couto Alves, Alexessander, Deelen, Joris, Fedko, Iryna O., Gordon, Scott D., Jiang, Tao, Karlsson, Robert, Kerrison, Nicola, Loe, Taylor K., Mangino, Massimo, Milaneschi, Yuri, Miraglio, Benjamin, Pervjakova, Natalia, Russo, Alessia, Surakka, Ida, van der Spek, Ashley, Verhoeven, Josine E., Amin, Najaf, Beekman, Marian, Blakemore, Alexandra I., Canzian, Federico, Hamby, Stephen E., Hottenga, Jouke-Jan, Jones, Peter D., Jousilahti, Pekka, Mägi, Reedik, Medland, Sarah E., Montgomery, Grant W., Nyholt, Dale R., Perola, Markus, Pietiläinen, Kirsi H., Salomaa, Veikko, Sillanpää, Elina, Suchiman, H. Eka, van Heemst, Diana, Willemsen, Gonneke, Agudo, Antonio, Boeing, Heiner, Boomsma, Dorret I., Chirlaque, Maria-Dolores, Fagherazzi, Guy, Ferrari, Pietro, Franks, Paul W., Gieger, Christian, Eriksson, Johan Gunnar, Gunter, Marc, Hagg, Sara, Hovatta, Iiris, Imaz, Liher, Kaprio, Jaakko, Kaaks, Rudolf, Key, Timothy, Krogh, Vittorio, Martin, Nicholas G., Melander, Olle, Metspalu, Andres, Moreno, Concha, Onland-Moret, N. Charlotte, Nilsson, Peter, Ong, Ken K., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Pedersen, Nancy L., Penninx, Brenda W. J. H., Quirós, J. Ramón, Riitta Jarvelin, Marjo, Rodríguez-Barranco, Miguel, Scott, Robert A., Severi, Gianluca, Slagboom, P. Eline, Spector, Tim D., Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, Uitterlinden, André G., van der Schouw, Yvonne T., van Duijn, Cornelia M., Weiderpass, Elisabete, Denchi, Eros Lazzerini, Matullo, Giuseppe, Butterworth, Adam S., Danesh, John, Samani, Nilesh J., Wareham, Nicholas J., Nelson, Christopher P., Langenberg, Claudia, and Codd, Veryan
Abstract: Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1 , PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.
Published: 2020
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27. The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke:a prospective study of 418 329 participants in the EPIC cohort across nine European countries

Author: Tong, Tammy Y. N., Appleby, Paul N., Key, Timothy J., Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Katzke, Verena, Kuhn, Tilman, Boeing, Heiner, Karakatsani, Anna, Peppa, Eleni, Trichopoulou, Antonia, Weiderpass, Elisabete, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Boer, Jolanda M. A., Verschuren, W. M. Monique, Quiros, J. Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Imaz, Liher, Chirlaque, Maria-Dolores, Moreno-Iribas, Conchi, Engstrom, Gunnar, Sonestedt, Emily, Lind, Marcus, Otten, Julia, Khaw, Kay-Tee, Aune, Dagfinn, Riboli, Elio, Wareham, Nicholas J., Imamura, Fumiaki, Forouhi, Nita G., di Angelantonio, Emanuele, Wood, Angela M., Butterworth, Adam S., Perez-Cornago, Aurora, Tong, Tammy Y. N., Appleby, Paul N., Key, Timothy J., Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Katzke, Verena, Kuhn, Tilman, Boeing, Heiner, Karakatsani, Anna, Peppa, Eleni, Trichopoulou, Antonia, Weiderpass, Elisabete, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Boer, Jolanda M. A., Verschuren, W. M. Monique, Quiros, J. Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Imaz, Liher, Chirlaque, Maria-Dolores, Moreno-Iribas, Conchi, Engstrom, Gunnar, Sonestedt, Emily, Lind, Marcus, Otten, Julia, Khaw, Kay-Tee, Aune, Dagfinn, Riboli, Elio, Wareham, Nicholas J., Imamura, Fumiaki, Forouhi, Nita G., di Angelantonio, Emanuele, Wood, Angela M., Butterworth, Adam S., and Perez-Cornago, Aurora
Abstract: Aim To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort.Methods and results We analysed data on 418 329 men and women from nine European countries, with an average of 12.7years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated using 24-h recalls. Multivariable-adjusted Cox regressions were used to estimate hazard ratios (HRs) for ischaemic and haemorrhagic stroke associated with consumption of red and processed meat, poultry, fish, dairy foods, eggs, cereals, fruit and vegetables, legumes, nuts and seeds, and dietary fibre. For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200g/day higher intake, 0.87; 0.82-0.93, P-trendConclusion Risk of ischaemic stroke was inversely associated with consumption of fruit and vegetables, dietary fibre, and dairy foods, while risk of haemorrhagic stroke was positively associated with egg consumption. The apparent differences in the associations highlight the importance of examining ischaemic and haemorrhagic stroke subtypes separately.
Published: 2020

28. The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries

Author: Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Tong, Tammy Y N, Appleby, Paul N, Key, Timothy J, Dahm, Christina C, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Karakatsani, Anna, Peppa, Eleni, Trichopoulou, Antonia, Weiderpass, Elisabete, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, Quirós, J Ramón, Agudo, Antonio, Rodríguez-Barranco, Miguel, Imaz, Liher, Chirlaque, María-Dolores, Moreno-Iribas, Conchi, Engström, Gunnar, Sonestedt, Emily, Lind, Marcus, Otten, Julia, Khaw, Kay-Tee, Aune, Dagfinn, Riboli, Elio, Wareham, Nicholas J, Imamura, Fumiaki, Forouhi, Nita G, di Angelantonio, Emanuele, Wood, Angela M, Butterworth, Adam S, Perez-Cornago, Aurora, Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Tong, Tammy Y N, Appleby, Paul N, Key, Timothy J, Dahm, Christina C, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Karakatsani, Anna, Peppa, Eleni, Trichopoulou, Antonia, Weiderpass, Elisabete, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, Quirós, J Ramón, Agudo, Antonio, Rodríguez-Barranco, Miguel, Imaz, Liher, Chirlaque, María-Dolores, Moreno-Iribas, Conchi, Engström, Gunnar, Sonestedt, Emily, Lind, Marcus, Otten, Julia, Khaw, Kay-Tee, Aune, Dagfinn, Riboli, Elio, Wareham, Nicholas J, Imamura, Fumiaki, Forouhi, Nita G, di Angelantonio, Emanuele, Wood, Angela M, Butterworth, Adam S, and Perez-Cornago, Aurora
Published: 2020

29. Genetic architectures of proximal and distal colorectal cancer are partly distinct

Author: Huyghe, Jeroen R, primary, Harrison, Tabitha A, additional, Bien, Stephanie A, additional, Hampel, Heather, additional, Figueiredo, Jane C, additional, Schmit, Stephanie L, additional, Conti, David V, additional, Chen, Sai, additional, Qu, Conghui, additional, Lin, Yi, additional, Barfield, Richard, additional, Baron, John A, additional, Cross, Amanda J, additional, Diergaarde, Brenda, additional, Duggan, David, additional, Harlid, Sophia, additional, Imaz, Liher, additional, Kang, Hyun Min, additional, Levine, David M, additional, Perduca, Vittorio, additional, Perez-Cornago, Aurora, additional, Sakoda, Lori C, additional, Schumacher, Fredrick R, additional, Slattery, Martha L, additional, Toland, Amanda E, additional, van Duijnhoven, Fränzel J B, additional, Van Guelpen, Bethany, additional, Agudo, Antonio, additional, Albanes, Demetrius, additional, Alonso, M Henar, additional, Anderson, Kristin, additional, Arnau-Collell, Coral, additional, Arndt, Volker, additional, Banbury, Barbara L, additional, Bassik, Michael C, additional, Berndt, Sonja I, additional, Bézieau, Stéphane, additional, Bishop, D Timothy, additional, Boehm, Juergen, additional, Boeing, Heiner, additional, Boutron-Ruault, Marie-Christine, additional, Brenner, Hermann, additional, Brezina, Stefanie, additional, Buch, Stephan, additional, Buchanan, Daniel D, additional, Burnett-Hartman, Andrea, additional, Caan, Bette J, additional, Campbell, Peter T, additional, Carr, Prudence R, additional, Castells, Antoni, additional, Castellví-Bel, Sergi, additional, Chan, Andrew T, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J, additional, Curtis, Keith R, additional, de la Chapelle, Albert, additional, Easton, Douglas F, additional, English, Dallas R, additional, Feskens, Edith J M, additional, Gala, Manish, additional, Gallinger, Steven J, additional, Gauderman, W James, additional, Giles, Graham G, additional, Goodman, Phyllis J, additional, Grady, William M, additional, Grove, John S, additional, Gsur, Andrea, additional, Gunter, Marc J, additional, Haile, Robert W, additional, Hampe, Jochen, additional, Hoffmeister, Michael, additional, Hopper, John L, additional, Hsu, Wan-Ling, additional, Huang, Wen-Yi, additional, Hudson, Thomas J, additional, Jenab, Mazda, additional, Jenkins, Mark A, additional, Joshi, Amit D, additional, Keku, Temitope O, additional, Kooperberg, Charles, additional, Kühn, Tilman, additional, Küry, Sébastien, additional, Le Marchand, Loic, additional, Lejbkowicz, Flavio, additional, Li, Christopher I, additional, Li, Li, additional, Lieb, Wolfgang, additional, Lindblom, Annika, additional, Lindor, Noralane M, additional, Männistö, Satu, additional, Markowitz, Sanford D, additional, Milne, Roger L, additional, Moreno, Lorena, additional, Murphy, Neil, additional, Nassir, Rami, additional, Offit, Kenneth, additional, Ogino, Shuji, additional, Panico, Salvatore, additional, Parfrey, Patrick S, additional, Pearlman, Rachel, additional, Pharoah, Paul D P, additional, Phipps, Amanda I, additional, Platz, Elizabeth A, additional, Potter, John D, additional, Prentice, Ross L, additional, Qi, Lihong, additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S, additional, Riboli, Elio, additional, Schafmayer, Clemens, additional, Schoen, Robert E, additional, Seminara, Daniela, additional, Song, Mingyang, additional, Su, Yu-Ru, additional, Tangen, Catherine M, additional, Thibodeau, Stephen N, additional, Thomas, Duncan C, additional, Trichopoulou, Antonia, additional, Ulrich, Cornelia M, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, Vodickova, Ludmila, additional, Vymetalkova, Veronika, additional, Weigl, Korbinian, additional, Weinstein, Stephanie J, additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O, additional, Wu, Anna H, additional, Abecasis, Goncalo R, additional, Nickerson, Deborah A, additional, Scacheri, Peter C, additional, Kundaje, Anshul, additional, Casey, Graham, additional, Gruber, Stephen B, additional, Hsu, Li, additional, Moreno, Victor, additional, Hayes, Richard B, additional, Newcomb, Polly A, additional, and Peters, Ulrike, additional
Published: 2021
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30. Fried-Food Consumption Does Not Increase the Risk of Stroke in the Spanish Cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Author: Rey-García, Jimena, primary, Guallar-Castillón, Pilar, additional, Donat-Vargas, Carolina, additional, Moreno-Iribas, Conchi, additional, Barricarte, Aurelio, additional, Rodriguez-Barranco, Miguel, additional, Colorado-Yohar, Sandra, additional, Huerta, José-María, additional, Chirlaque, María-Dolores, additional, Lasheras, Cristina, additional, Amiano, Pilar, additional, Imaz, Liher, additional, Agudo, Antonio, additional, and Sánchez, María-José, additional
Published: 2020
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31. Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Perez-Cornago, Aurora, primary, Crowe, Francesca L, additional, Appleby, Paul N, additional, Bradbury, Kathryn E, additional, Wood, Angela M, additional, Jakobsen, Marianne Uhre, additional, Johnson, Laura, additional, Sacerdote, Carlotta, additional, Steur, Marinka, additional, Weiderpass, Elisabete, additional, Würtz, Anne Mette L, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, La Vecchia, Carlo, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Sluijs, Ivonne, additional, Skeie, Guri, additional, Imaz, Liher, additional, Petrova, Dafina, additional, Quirós, J Ramón, additional, Yohar, Sandra Milena Colorado, additional, Jakszyn, Paula, additional, Melander, Olle, additional, Sonestedt, Emily, additional, Andersson, Jonas, additional, Wennberg, Maria, additional, Aune, Dagfinn, additional, Riboli, Elio, additional, Schulze, Matthias B, additional, di Angelantonio, Emanuele, additional, Wareham, Nicholas J, additional, Danesh, John, additional, Forouhi, Nita G, additional, Butterworth, Adam S, additional, and Key, Timothy J, additional
Published: 2020
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32. Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA–INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study

Author: Santa-Marina, Loreto, primary, Lertxundi, Nerea, additional, Andiarena, Ainara, additional, Irizar, Amaia, additional, Sunyer, Jordi, additional, Molinuevo, Amaia, additional, Llop, Sabrina, additional, Julvez, Jordi, additional, Beneito, Andrea, additional, Ibarluzea, Jesús, additional, Imaz, Liher, additional, and Ferrin, Maite, additional
Published: 2020
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33. Antibody Responses to Helicobacter pylori and Risk of Developing Colorectal Cancer in a European Cohort

Author: Butt, Julia, primary, Jenab, Mazda, additional, Pawlita, Michael, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Boutron-Ruault, Marie-Christine, additional, Carbonnel, Franck, additional, Dong, Catherine, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Schulze, Matthias B., additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, La Vecchia, Carlo, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel, additional, Gram, Inger T., additional, Weiderpass, Elisabete, additional, Borch, Kristin Benjaminsen, additional, Quirós, Jose Ramón, additional, Agudo, Antonio, additional, Rodríguez-Barranco, Miguel, additional, Santiuste, Carmen, additional, Ardanaz, Eva, additional, Van Guelpen, Bethany, additional, Harlid, Sophia, additional, Imaz, Liher, additional, Perez-Cornago, Aurora, additional, Gunter, Marc J., additional, Zouiouich, Semi, additional, Park, Jin Young, additional, Riboli, Elio, additional, Cross, Amanda J., additional, Heath, Alicia K., additional, Waterboer, Tim, additional, and Hughes, David J., additional
Published: 2020
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34. Impact of an organised population screening programme for colorectal cancer: Measurement after first and second rounds

Author: Mar, Javier, primary, Arrospide, Arantzazu, additional, Larrañaga, Igor, additional, Iruretagoiena, Maria Luisa, additional, Imaz, Liher, additional, Gorostiza, Ania, additional, and Ibarrondo, Oliver, additional
Published: 2020
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35. Genetic architectures of proximal and distal colorectal cancer are partly distinct

Author: Huyghe, Jeroen R, primary, Harrison, Tabitha A, additional, Bien, Stephanie A, additional, Hampel, Heather, additional, Figueiredo, Jane C, additional, Schmit, Stephanie L, additional, Conti, David V, additional, Chen, Sai, additional, Qu, Conghui, additional, Lin, Yi, additional, Barfield, Richard, additional, Baron, John A, additional, Cross, Amanda J, additional, Diergaarde, Brenda, additional, Duggan, David, additional, Harlid, Sophia, additional, Imaz, Liher, additional, Kang, Hyun Min, additional, Levine, David M, additional, Perduca, Vittorio, additional, Perez-Cornago, Aurora, additional, Sakoda, Lori C, additional, Schumacher, Fredrick R, additional, Slattery, Martha L, additional, Toland, Amanda E, additional, van Duijnhoven, Franzel JB, additional, Van Guelpen, Bethany, additional, Arndt, Volker, additional, Agudo, Antonio, additional, Albanes, Demetrius, additional, Alonso, M Henar, additional, Anderson, Kristin, additional, Arnau-Collell, Coral, additional, Banbury, Barbara, additional, Bassik, Michael C, additional, Berndt, Sonja I, additional, Bézieau, Stéphane, additional, Bishop, D Timothy, additional, Boehm, Juergen, additional, Boeing, Heiner, additional, Boutron-Ruault, Marie-Christine, additional, Brenner, Hermann, additional, Brezina, Stefanie, additional, Buch, Stephan, additional, Buchanan, Daniel D, additional, Burnett-Hartman, Andrea, additional, Caan, Bette J, additional, Campbell, Peter T, additional, Carr, Prudence, additional, Castells, Antoni, additional, Castellví-Bel, Sergi, additional, Chan, Andrew T, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J, additional, Curtis, Keith R, additional, de la Chapelle, Albert, additional, Easton, Douglas F, additional, English, Dallas R, additional, Feskens, Edith JM, additional, Gala, Manish, additional, Gallinger, Steven J, additional, Gauderman, W James, additional, Giles, Graham G, additional, Goodman, Phyllis J, additional, Grady, William M, additional, Grove, John S, additional, Gsur, Andrea, additional, Gunter, Marc J, additional, Haile, Robert W, additional, Hampe, Jochen, additional, Hoffmeister, Michael, additional, Hopper, John L, additional, Hsu, Wan-Ling, additional, Huang, Wen-Yi, additional, Hudson, Thomas J, additional, Jenab, Mazda, additional, Jenkins, Mark A, additional, Joshi, Amit D, additional, Keku, Temitope O, additional, Kooperberg, Charles, additional, Kuhn, Tilman, additional, Küry, Sébastien, additional, Le Marchand, Loic, additional, Lejbkowicz, Flavio, additional, Li, Christopher I, additional, Li, Li, additional, Lieb, Wolfgang, additional, Lindblom, Annika, additional, Lindor, Noralane M, additional, Männistö, Satu, additional, Markowitz, Sanford D, additional, Milne, Roger L, additional, Moreno, Lorena, additional, Murphy, Neil, additional, Nassir, Rami, additional, Offit, Kenneth, additional, Ogino, Shuji, additional, Panico, Salvatore, additional, Parfrey, Patrick S, additional, Pearlman, Rachel, additional, Pharoah, Paul D P, additional, Phipps, Amanda I, additional, Platz, Elizabeth A, additional, Potter, John D, additional, Prentice, Ross L, additional, Qi, Lihong, additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S, additional, Riboli, Elio, additional, Schafmayer, Clemens, additional, Schoen, Robert E, additional, Seminara, Daniela, additional, Song, Mingyang, additional, Su, Yu-Ru, additional, Tangen, Catherine M, additional, Thibodeau, Stephen N, additional, Thomas, Duncan C, additional, Trichopoulou, Antonia, additional, Ulrich, Cornelia M, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, Vodickova, Ludmila, additional, Vymetalkova, Veronika, additional, Weigl, Korbinian, additional, Weinstein, Stephanie J, additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O, additional, Wu, Anna H, additional, Abecasis, Goncalo R, additional, Nickerson, Deborah A, additional, Scacheri, Peter C, additional, Kundaje, Anshul, additional, Casey, Graham, additional, Gruber, Stephen B, additional, Hsu, Li, additional, Moreno, Victor, additional, Hayes, Richard B, additional, Newcomb, Polly A, additional, and Peters, Ulrike, additional
Published: 2020
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36. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Author: Li, Chen, primary, Stoma, Svetlana, additional, Lotta, Luca A., additional, Warner, Sophie, additional, Albrecht, Eva, additional, Allione, Alessandra, additional, Arp, Pascal P., additional, Broer, Linda, additional, Buxton, Jessica L., additional, Da Silva Couto Alves, Alexessander, additional, Deelen, Joris, additional, Fedko, Iryna O., additional, Gordon, Scott D., additional, Jiang, Tao, additional, Karlsson, Robert, additional, Kerrison, Nicola, additional, Loe, Taylor K., additional, Mangino, Massimo, additional, Milaneschi, Yuri, additional, Miraglio, Benjamin, additional, Pervjakova, Natalia, additional, Russo, Alessia, additional, Surakka, Ida, additional, van der Spek, Ashley, additional, Verhoeven, Josine E., additional, Amin, Najaf, additional, Beekman, Marian, additional, Blakemore, Alexandra I., additional, Canzian, Federico, additional, Hamby, Stephen E., additional, Hottenga, Jouke-Jan, additional, Jones, Peter D., additional, Jousilahti, Pekka, additional, Mägi, Reedik, additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Nyholt, Dale R., additional, Perola, Markus, additional, Pietiläinen, Kirsi H., additional, Salomaa, Veikko, additional, Sillanpää, Elina, additional, Suchiman, H. Eka, additional, van Heemst, Diana, additional, Willemsen, Gonneke, additional, Agudo, Antonio, additional, Boeing, Heiner, additional, Boomsma, Dorret I., additional, Chirlaque, Maria-Dolores, additional, Fagherazzi, Guy, additional, Ferrari, Pietro, additional, Franks, Paul, additional, Gieger, Christian, additional, Eriksson, Johan Gunnar, additional, Gunter, Marc, additional, Hägg, Sara, additional, Hovatta, Iiris, additional, Imaz, Liher, additional, Kaprio, Jaakko, additional, Kaaks, Rudolf, additional, Key, Timothy, additional, Krogh, Vittorio, additional, Martin, Nicholas G., additional, Melander, Olle, additional, Metspalu, Andres, additional, Moreno, Concha, additional, Onland-Moret, N. Charlotte, additional, Nilsson, Peter, additional, Ong, Ken K., additional, Overvad, Kim, additional, Palli, Domenico, additional, Panico, Salvatore, additional, Pedersen, Nancy L., additional, Penninx, Brenda W.J. H., additional, Quirós, J. Ramón, additional, Jarvelin, Marjo Riitta, additional, Rodríguez-Barranco, Miguel, additional, Scott, Robert A., additional, Severi, Gianluca, additional, Slagboom, P. Eline, additional, Spector, Tim D., additional, Tjonneland, Anne, additional, Trichopoulou, Antonia, additional, Tumino, Rosario, additional, Uitterlinden, André G., additional, van der Schouw, Yvonne T., additional, van Duijn, Cornelia M., additional, Weiderpass, Elisabete, additional, Denchi, Eros Lazzerini, additional, Matullo, Giuseppe, additional, Butterworth, Adam S., additional, Danesh, John, additional, Samani, Nilesh J., additional, Wareham, Nicholas J., additional, Nelson, Christopher P., additional, Langenberg, Claudia, additional, and Codd, Veryan, additional
Published: 2020
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37. The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries

Author: Tong, Tammy Y N, primary, Appleby, Paul N, additional, Key, Timothy J, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Katzke, Verena, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Karakatsani, Anna, additional, Peppa, Eleni, additional, Trichopoulou, Antonia, additional, Weiderpass, Elisabete, additional, Masala, Giovanna, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Boer, Jolanda M A, additional, Verschuren, W M Monique, additional, Quirós, J Ramón, additional, Agudo, Antonio, additional, Rodríguez-Barranco, Miguel, additional, Imaz, Liher, additional, Chirlaque, María-Dolores, additional, Moreno-Iribas, Conchi, additional, Engström, Gunnar, additional, Sonestedt, Emily, additional, Lind, Marcus, additional, Otten, Julia, additional, Khaw, Kay-Tee, additional, Aune, Dagfinn, additional, Riboli, Elio, additional, Wareham, Nicholas J, additional, Imamura, Fumiaki, additional, Forouhi, Nita G, additional, di Angelantonio, Emanuele, additional, Wood, Angela M, additional, Butterworth, Adam S, additional, and Perez-Cornago, Aurora, additional
Published: 2020
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38. Impact of an organised population screening programme for colorectal cancer: Measurement after first and second rounds.

Author: Mar, Javier, Arrospide, Arantzazu, Larrañaga, Igor, Iruretagoiena, Maria Luisa, Imaz, Liher, Gorostiza, Ania, and Ibarrondo, Oliver
Subjects: PUBLIC health surveillance, EARLY detection of cancer, METASTASIS, REGRESSION analysis, COLORECTAL cancer, TUMOR classification, COMPARATIVE studies, CANCER patients, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, HEALTH impact assessment, PROPORTIONAL hazards models
Abstract: Objective: The first and second rounds of the Basque programme for organised colorectal cancer screening were implemented between 2009 and 2014. Our objective was to measure the changes in incidence, tumour, node, metastasis staging distribution and tumour, node, metastasis-adjusted survival of patients with colorectal cancer from 2003 to 2014. Method: Colorectal cancer cases with screening (patients <70 years old) and without screening (patients≥70 years old) were compared during three four-year periods: 2003-2006, 2007-2010 and 2011-2014 (fully implemented phase). Cox regression, five-year relative survival and cancer probability of death were calculated for each four-year period, age group and tumour, node, metastasis stage. Adjusted incidence rates were analysed by joinpoint regression. Results: In an analysis of 23,301 cases of colorectal cancer, the incidence in patients younger than 70 years in 2013 showed a 17% annual decrease. The survival hazard ratios for stages I, II and III for 2003-2006 and 2007-2010 were compared to those for 2011-2014. From the first to the third period, diagnosis in the early stages (I and II) rose from 45.1% to 50.9% in the younger patient group and remained stable in the older group (49.6% and 49.4%). Additionally, the five-year relative survival rate increased significantly from 0.67 to 0.82 in those patients younger than 70 years, whereas in patients 70 years or older the rate did not change significantly (0.61 and 0.65). Conclusion: The screening reduced incidence and improved survival by anticipating the diagnosis and by reducing mortality for each tumour, node, metastasis stage in the target population. The effect on survival could also be due to lead-time bias. [ABSTRACT FROM AUTHOR]
Published: 2021
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39. Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Perez-Cornago, Aurora, Crowe, Francesca L, Appleby, Paul N, Bradbury, Kathryn E, Wood, Angela M, Jakobsen, Marianne Uhre, Johnson, Laura, Sacerdote, Carlotta, Steur, Marinka, Weiderpass, Elisabete, Würtz, Anne Mette L, Kühn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Masala, Giovanna, Tumino, Rosario, Panico, Salvatore, Sluijs, Ivonne, Skeie, Guri, Imaz, Liher, Petrova, Dafina, Quirós, J Ramón, Yohar, Sandra Milena Colorado, Jakszyn, Paula, Melander, Olle, Sonestedt, Emily, Andersson, Jonas, Wennberg, Maria, Aune, Dagfinn, Riboli, Elio, Schulze, Matthias B, Di Angelantonio, Emanuele, Wareham, Nicholas J, Danesh, John, Forouhi, Nita G, Butterworth, Adam S, and Key, Timothy J
Subjects: 2. Zero hunger, vegetables, Dietary Fiber, Male, legumes, Myocardial Ischemia, food and beverages, nuts, seeds, 3. Good health, Diet, Europe, Risk Factors, Fruit, Neoplasms, Humans, Female, Prospective Studies, coronary heart disease, Life Style
Abstract: BACKGROUND: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD. RESULTS: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk. CONCLUSIONS: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear.

40. Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries

Author: Steur, Marinka, Johnson, Laura, Sharp, Stephen J, Imamura, Fumiaki, Sluijs, Ivonne, Key, Timothy J, Wood, Angela, Chowdhury, Rajiv, Guevara, Marcela, Jakobsen, Marianne U, Johansson, Ingegerd, Koulman, Albert, Overvad, Kim, Sánchez, Maria-José, Van Der Schouw, Yvonne T, Trichopoulou, Antonia, Weiderpass, Elisabete, Wennberg, Maria, Zheng, Ju-Sheng, Boeing, Heiner, Boer, Jolanda MA, Boutron-Ruault, Marie-Christine, Ericson, Ulrika, Heath, Alicia K, Huybrechts, Inge, Imaz, Liher, Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kyrø, Cecilie, Masala, Giovanna, Melander, Olle, Moreno-Iribas, Conchi, Panico, Salvatore, Quirós, José R, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Santiuste, Carmen, Skeie, Guri, Tjønneland, Anne, Tumino, Rosario, Verschuren, WM Monique, Zamora-Ros, Raul, Dahm, Christina C, Perez-Cornago, Aurora, Schulze, Matthias B, Tong, Tammy YN, Riboli, Elio, Wareham, Nicholas J, Danesh, John, Butterworth, Adam S, and Forouhi, Nita G
Subjects: 2. Zero hunger, saturated fat, Incidence, primary prevention, Fatty Acids, Coronary Disease, Nutrients, Dietary Fats, 3. Good health, Cohort Studies, Europe, nutritional epidemiology, Food, Humans, coronary heart disease, dietary guidelines
Abstract: Background There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. Methods and Results We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88-0.99]), cheese (HR, 0.98 [95% CI, 0.96-1.00]), and fish (HR, 0.87 [95% CI, 0.75-1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02-1.12]) and butter (HR, 1.02 [95% CI, 1.00-1.04]). Conclusions This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite directions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.

41. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Author: Li, Chen, Stoma, Svetlana, Lotta, Luca A, Warner, Sophie, Albrecht, Eva, Allione, Alessandra, Arp, Pascal P, Broer, Linda, Buxton, Jessica L, Da Silva Couto Alves, Alexessander, Deelen, Joris, Fedko, Iryna O, Gordon, Scott D, Jiang, Tao, Karlsson, Robert, Kerrison, Nicola, Loe, Taylor K, Mangino, Massimo, Milaneschi, Yuri, Miraglio, Benjamin, Pervjakova, Natalia, Russo, Alessia, Surakka, Ida, Van Der Spek, Ashley, Verhoeven, Josine E, Amin, Najaf, Beekman, Marian, Blakemore, Alexandra I, Canzian, Federico, Hamby, Stephen E, Hottenga, Jouke-Jan, Jones, Peter D, Jousilahti, Pekka, Mägi, Reedik, Medland, Sarah E, Montgomery, Grant W, Nyholt, Dale R, Perola, Markus, Pietiläinen, Kirsi H, Salomaa, Veikko, Sillanpää, Elina, Suchiman, H Eka, Van Heemst, Diana, Willemsen, Gonneke, Agudo, Antonio, Boeing, Heiner, Boomsma, Dorret I, Chirlaque, Maria-Dolores, Fagherazzi, Guy, Ferrari, Pietro, Franks, Paul, Gieger, Christian, Eriksson, Johan Gunnar, Gunter, Marc, Hägg, Sara, Hovatta, Iiris, Imaz, Liher, Kaprio, Jaakko, Kaaks, Rudolf, Key, Timothy, Krogh, Vittorio, Martin, Nicholas G, Melander, Olle, Metspalu, Andres, Moreno, Concha, Onland-Moret, N Charlotte, Nilsson, Peter, Ong, Ken K, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Pedersen, Nancy L, Penninx, Brenda WJH, Quirós, J Ramón, Jarvelin, Marjo Riitta, Rodríguez-Barranco, Miguel, Scott, Robert A, Severi, Gianluca, Slagboom, P Eline, Spector, Tim D, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, Uitterlinden, André G, Van Der Schouw, Yvonne T, Van Duijn, Cornelia M, Weiderpass, Elisabete, Denchi, Eros Lazzerini, Matullo, Giuseppe, Butterworth, Adam S, Danesh, John, Samani, Nilesh J, Wareham, Nicholas J, Nelson, Christopher P, Langenberg, Claudia, and Codd, Veryan
Subjects: age-related disease, Nucleotides, biological aging, telomere length, Leukocytes, Humans, Telomere, Mendelian randomisation, 3. Good health, Genome-Wide Association Study
Abstract: Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1, PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.

42. Dietary fatty acids, macronutrient substitutions, food sources and incidence of coronary heart disease: Findings from the EPIC-CVD case-cohort study across nine european countries

Author: Matthias B. Schulze, Vittorio Krogh, Rosario Tumino, Nita G. Forouhi, Christina C. Dahm, Kim Overvad, Marie-Christine Boutron-Ruault, Angela M. Wood, Yvonne T. van der Schouw, Guri Skeie, Laura Johnson, Fumiaki Imamura, Ivonne Sluijs, José R Quirós, Elisabete Weiderpass, Nicholas J. Wareham, Timothy J. Key, Adam S. Butterworth, Giovanna Masala, Alicia K Heath, Albert Koulman, Conchi Moreno-Iribas, Inge Huybrechts, John Danesh, Stephen J. Sharp, Salvatore Panico, Carlotta Sacerdote, Aurora Perez-Cornago, Olle Melander, Rudolf Kaaks, Elio Riboli, Tammy Y.N. Tong, María José Sánchez, Rajiv Chowdhury, Ju-Sheng Zheng, Miguel Rodríguez-Barranco, W M Monique Verschuren, Marinka Steur, Ingegerd Johansson, Heiner Boeing, Anne Tjønneland, Carmen Santiuste, Antonia Trichopoulou, Maria Wennberg, Jolanda M. A. Boer, Marcela Guevara, Cecilie Kyrø, Raul Zamora-Ros, Liher Imaz, Tilman Kühn, Marianne Uhre Jakobsen, Ulrika Ericson, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, G0800270, MR/L003120/1, Pfizer, AstraZeneca, Kræftens Bekæmpelse, DCS, Deutsches Krebsforschungszentrum, DKFZ, Centre International de Recherche sur le Cancer, CIRC, Merck Sharp and Dohme, MSD, Seventh Framework Programme, FP7: HEALTH-F2-2012-279233, National Research Council, NRC, University of Maryland School of Public Health, SPH, Medical Research Council, MRC: MC_UU_00006/1, National Institute for Health Research, NIHR, British Heart Foundation, BHF: RG/18/13/33946, RG13/13/30194, SP/09/002, Cancer Research UK, CRUK: C8221/A29017, MR/M012190/1, World Cancer Research Fund, WCRF, Imperial College London, European Research Council, ERC: 268834, Institut National de la Santé et de la Recherche Médicale, Inserm, Bundesministerium für Bildung und Forschung, BMBF, Cancerfonden, Ministerie van Volksgezondheid, Welzijn en Sport, VWS, Ligue Contre le Cancer, Vetenskapsrådet, VR, Instituto de Salud Carlos III, ISCIII, European Social Fund, ESF, Sixth Framework Programme, FP6: LSHM_CT_2006_037197, Associazione Italiana per la Ricerca sul Cancro, AIRC, Deutsche Krebshilfe, Akademi Sains Malaysia, ASM: MR/P013880/1, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, MGEN, UCLH Biomedical Research Centre, NIHR BRC: BRC-1215-20014, NIHR Imperial Biomedical Research Centre, BRC, Hellenic Health Foundation, HHF: CP15/00100, IS-BRC-1215-20014, MC_UU_00006/3, Dr Danesh reports grants, personal fees and non-financial support from Merck Sharp & Dohme, grants, personal fees, and nonfinancial support from Novartis, grants from Pfizer, and grants from AstraZeneca outside the submitted work. He is member of the International Cardiovascular and Metabolic Advisory Board for Novartis (since 2010), the Steering Committee of UK Biobank (since 2011), the MRC International Advisory Group (ING) member, London (since 2013), the MRC High Throughput Science ‘Omics Panel Member, London (since 2013), the Scientific Advisory Committee for Sanofi (since 2013), the International Cardiovascular and Metabolism Research and Development Portfolio Committee for Novartis, and the Astra Zeneca Genomics Advisory Board (2018). Dr Butterworth reports grants outside of this work from AstraZeneca, Biogen, BioMarin, Bioverativ, Merck, Novartis, Pfizer, and Sanofi and personal fees from Novartis. The remaining authors have no disclosures to report., EPIC-CVD was supported by the European Commission Framework Programme 7 (HEALTH-F2-2012-279233), and the European Research Council (268834). The coordinating center was supported by core funding from the: United Kingdom MRC (G0800270, MR/L003120/1), British Heart Foundation (BHF) (SP/09/002, RG13/13/30194, RG/18/13/33946), and National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (BRC) (BRC-1215-20014).* The establishment of the study subcohort was supported by the European Union Sixth Framework Programme (grant LSHM_CT_2006_037197 to the InterAct project) and the MRC Epidemiology Unit (grant MC_UU_00006/1). The coordination of EPIC is financially supported by International Agency for Research on Cancer and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by NIHR Imperial BRC. The national cohorts are supported by: Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (France), German Cancer Aid, German Cancer Research Center, German Institute of Human Nutrition Potsdam-Rehbruecke, Federal Ministry of Education and Research (Germany), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports, Netherlands Cancer Registry, LK Research Funds, Dutch Prevention Funds, Zorg Onderzoek Nederland, World Cancer Research Fund, Statistics Netherlands (the Netherlands), Health Research Fund– Instituto de Salud Carlos III, Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology (Spain), Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden), Cancer Research UK (14136 to EPIC-Norfolk, C8221/A29017 to EPIC-Oxford), MRC (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom). EPIC-Greece was supported by the Hellenic Health Foundation (Greece). M.S., N.J.W., N.G.F., and F.I. acknowledge support from MRC Epidemiology Unit (MC_UU_00006/1 and MC_UU_00006/3). N.J.W. and N.G.F. acknowledge support from NIHR* Cambridge BRC: Nutrition, Diet, and Lifestyle Research Theme (IS-BRC-1215-20014) and NGF is a NIHR Senior Investigator Award holder. M.S. was also supported by BHF for part of this work while working in the BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. R.Z.-R. thanks the 'Miguel Servet' program (CP15/00100) from the Institute of Health Carlos III (co-funded by the European Social Fund–European Social Fund Investing in Your Future). A.W. was supported by a BHF-Turing Cardiovascular Data Science Award and by the European Commission-Innovative Medicines Initiative (BigData@Heart). R.C. was funded by a MRC-Newton project grant to study genetic risk factors of cardiovascular disease among Southeast Asian people and the Academy of Sciences Malaysia (grant no. MR/P013880/1) and a United Kingdom Research and Innovation-Global Challenges Research Fund Project Grant to study risk factors of noncommunicable diseases in Bangladesh. J.D. holds a BHF Professorship and a NIHR Senior Investigator Award., Steur, Marinka [0000-0002-9028-0290], Imamura, Fumiaki [0000-0002-6841-8396], Key, Timothy J [0000-0003-2294-307X], Chowdhury, Rajiv [0000-0003-4881-5690], Guevara, Marcela [0000-0001-9242-6364], Jakobsen, Marianne U [0000-0001-6518-4136], Johansson, Ingegerd [0000-0002-9227-8434], Weiderpass, Elisabete [0000-0003-2237-0128], Boer, Jolanda MA [0000-0002-9714-4304], Boutron-Ruault, Marie-Christine [0000-0002-5956-5693], Heath, Alicia K [0000-0001-6517-1300], Huybrechts, Inge [0000-0003-3838-855X], Imaz, Liher [0000-0002-3777-4953], Masala, Giovanna [0000-0002-5758-9069], Zamora-Ros, Raul [0000-0002-6236-6804], Perez-Cornago, Aurora [0000-0002-5652-356X], Tong, Tammy YN [0000-0002-0284-8959], Wareham, Nicholas J [0000-0003-1422-2993], Forouhi, Nita G [0000-0002-5041-248X], and Apollo - University of Cambridge Repository
Subjects: Saturated fat, Physiology, Coronary Disease, 030204 cardiovascular system & hematology, EPIC, Cohort Studies, 0302 clinical medicine, Medicine, Cardiac and Cardiovascular Systems, 030212 general & internal medicine, 1102 Cardiorespiratory Medicine and Haematology, 2. Zero hunger, chemistry.chemical_classification, Nutrition and Dietetics, Kardiologi, Primary prevention, Incidence, Incidence (epidemiology), Fatty Acids, Fatty acids in human nutrition, 3. Good health, Europe, Näringslära, Coronary heart disease, Dietary guidelines, Cardiology and Cardiovascular Medicine, Polyunsaturated fatty acid, Cohort study, Malalties coronàries, 03 medical and health sciences, SDG 3 - Good Health and Well-being, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Àcids grassos en la nutrició, Diseases of the circulatory (Cardiovascular) system, Humans, Nutritional epidemiology, business.industry, Nutrients, Dietary Fats, chemistry, Food, RC666-701, SPS Exercise, Nutrition and Health Sciences, business
Abstract: EPIC-CVD was supported by the European Commission Framework Programme 7 (HEALTH-F2-2012-279233), and the European Research Council (268834). The coordinating center was supported by core funding from the: United Kingdom MRC (G0800270; MR/L003120/1), British Heart Foundation (BHF) (SP/09/002; RG13/13/30194; RG/18/13/33946), and National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (BRC) (BRC-1215-20014).* The establishment of the study subcohort was supported by the European Union Sixth Framework Programme (grant LSHM_CT_ 2006_037197 to the InterAct project) and the MRC Epidemiology Unit (grant MC_UU_00006/1). The coordination of EPIC is financially supported by International Agency for Research on Cancer and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by NIHR Imperial BRC. The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (France); German Cancer Aid, German Cancer Research Center, German Institute of Human Nutrition Potsdam-Rehbruecke, Federal Ministry of Education and Research (Germany); Associazione Italiana per la Ricerca sul Cancro--AIRC--Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports, Netherlands Cancer Registry, LK Research Funds, Dutch Prevention Funds, Zorg Onderzoek Nederland, World Cancer Research Fund, Statistics Netherlands (the Netherlands); Health Research Fund-Instituto de Salud Carlos III, Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skane and Vasterbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), MRC (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (United Kingdom). EPIC-Greece was supported by the Hellenic Health Foundation (Greece). M.S., N.J.W., N.G.F., and F.I. acknowledge support from MRC Epidemiology Unit (MC_UU_ 00006/1 and MC_UU_00006/3). N.J.W. and N.G.F. acknowledge support from NIHR* Cambridge BRC: Nutrition, Diet, and Lifestyle Research Theme (IS-BRC-1215--20014) and NGF is a NIHR Senior Investigator Award holder. M.S. was also supported by BHF for part of this work while working in the BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. R. Z.-R. thanks the "Miguel Servet" program (CP15/00100) from the Institute of Health Carlos III (co-funded by the European Social Fund--European Social Fund Investing in Your Future). A.W. was supported by a BHF-Turing Cardiovascular Data Science Award and by the European Commission-Innovative Medicines Initiative (BigData@Heart).R.C.was funded by a MRC-Newton project grant to study genetic risk factors of cardiovascular disease among Southeast Asian people and the Academy of Sciences Malaysia (grant no. MR/P013880/1) and a United Kingdom Research and Innovation-Global Challenges Research Fund Project Grant to study risk factors of noncommunicable diseases in Bangladesh. J.D. holds a BHF Professorship and a NIHR Senior Investigator Award. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. Where authors are identified as personnel of the International Agency for Research on Cancer/World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy, or views of the International Agency for Research on Cancer/World Health Organization. The funders of the study had no role in study design, data collection, analysis, data interpretation, or writing of the article, or in the decision to submit for publication. M.S. had full access to all the data in the study, and M.S. and N.G.F. had final responsibility for the decision to submit for publication., BACKGROUND: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. METHODS AND RESULTS: We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88–0.99]), cheese (HR, 0.98 [95% CI, 0.96–1.00]), and fish (HR, 0.87 [95% CI, 0.75–1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02–1.12]) and butter (HR, 1.02 [95% CI, 1.00–1.04]). CONCLUSIONS: This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite directions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix., European Commission Framework Programme 7 HEALTH-F2-2012-279233, European Research Council (ERC), European Commission 268834, UK Research & Innovation (UKRI), Medical Research Council UK (MRC) G0800270 MR/L003120/1, British Heart Foundation SP/09/002 RG13/13/30194 RG/18/13/33946, National Institute for Health Research (NIHR) BRC-1215-20014, European Commission LSHM_CT_ 2006_037197, Medical Research Council UK (MRC) MC_UU_ 00006/1 MC_UU_00006/3, International Agency for Research on Cancer, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Danish Cancer Society, Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (France), German Cancer Aid, German Cancer Research Center, German Institute of Human Nutrition Potsdam, Rehbruecke, Federal Ministry of Education and Research (Germany), Fondazione AIRC per la ricerca sul cancro, Compagnia di San Paolo, Dutch Ministry of Public Health, Welfare and Sports, Netherlands Cancer Registry, LK Research Funds, Dutch Prevention Funds, Zorg Onderzoek Nederland, World Cancer Research Fund International (WCRF), Netherlands Government, Instituto de Salud Carlos III, Junta de Andalucia, Regional Government of Asturias, Basque Government, Regional Government of Murcia, Regional Government of Navarra, Catalan Institute of Oncology (Spain), Swedish Cancer Society, County Council of Skane (Sweden), County Council of Vasterbotten (Sweden), Cancer Research UK 14136 C8221/A29017, Medical Research Council UK (MRC) 1000143 MR/M012190/1, Hellenic Health Foundation (Greece), NIHR* Cambridge BRC: Nutrition, Diet, and Lifestyle Research Theme IS-BRC-1215-20014, British Heart Foundation, Institute of Health Carlos III (European Social Fund-European Social Fund Investing in Your Future) CP15/00100, BHF-Turing Cardiovascular Data Science Award, European Commission-Innovative Medicines Initiative (BigData@Heart), MRC-Newton project grant MR/P013880/1, United Kingdom Research and Innovation-Global Challenges Research Fund, NIHR Senior Investigator Award
Published: 2021
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43. Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Author: Perez-Cornago A, Crowe FL, Appleby PN, Bradbury KE, Wood AM, Jakobsen MU, Johnson L, Sacerdote C, Steur M, Weiderpass E, Würtz AML, Kühn T, Katzke V, Trichopoulou A, Karakatsani A, La Vecchia C, Masala G, Tumino R, Panico S, Sluijs I, Skeie G, Imaz L, Petrova D, Quirós JR, Yohar SMC, Jakszyn P, Melander O, Sonestedt E, Andersson J, Wennberg M, Aune D, Riboli E, Schulze MB, di Angelantonio E, Wareham NJ, Danesh J, Forouhi NG, Butterworth AS, and Key TJ
Subjects: Diet, Dietary Fiber, Europe, Female, Humans, Life Style, Male, Prospective Studies, Risk Factors, Myocardial Ischemia epidemiology, Neoplasms
Abstract: Background: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)., Methods: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD., Results: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk., Conclusions: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear., (© The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.)
Published: 2021
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