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2. Prognostic Factors for Chronic Active Epstein-Barr Virus Infection

Author

Members of the Japanese Association for Research on Epstein-Barr Virus and Related Diseases, Kimura, Hiroshi, Morishima, Tsuneo, Kanegane, Hirokazu, Ohga, Shouichi, Hoshino, Yo, Maeda, Akihiko, Imai, Shosuke, Okano, Motohiko, Morio, Tomohiro, Yokota, Shumpei, Tsuchiya, Shigeru, Yachie, Akihiro, Imashuku, Shinsaku, Kawa, Keisei, and Wakiguchi, Hiroshi

Published
2003

14. Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage [phi]MR11. (Major Article)

Author

Matsuzaki, Shigenobu, Yasuda, Masaharu, Nishikawa, Hiroshi, Kuroda, Masayuki, Ujihara, Takako, Shuin, Taro, Shen, Yuan, Jin, Zhe, Fujimoto, Shigeyoshi, Nasimuzzaman, M.D., Wakiguchi, Hiroshi, Sugihara, Shigeyoshi, Sugiura, Tetsuro, Koda, Shigeki, Muraoka, Asako, and Imai, Shosuke

Subjects
Staphylococcus -- Research, Staphylococcus -- Evaluation, Infection -- Research, Infection -- Evaluation, Mice as laboratory animals -- Usage, Health
Published
2003

15. Prognostic factors for chronic active Epstein-Barr virus infection. (Major Article)

Author

Kimura, Hiroshi, Morishima, Tsuneo, Kanegane, Hirokazu, Ohga, Shouichi, Hoshino, Yo, Maeda, Akihiko, Imai, Shosuke, Okano, Motohiko, Morio, Tomohiro, Yokota, Shumpei, Tsuchiya, Shigeru, Yachie, Akihiro, Imashuku, Shinsaku, Kawa, Keisei, and Wakiguchi, Hiroshi

Subjects
Epstein-Barr virus -- Research, Prognosis -- Methods, Mortality -- Research, Mortality -- Risk factors, Risk factors (Health) -- Research, Mortality -- Japan, Health
Published
2003

19. Promoter hypermethylation of the bone morphogenetic protein-6 gene in malignant lymphoma

Author

Daibata, Masanori, Nemoto, Yuiko, Bandobashi, Kentaro, Kotani, Norihiro, Kuroda, Masayuki, Tsuchiya, Mutsumi, Okuda, Heiwa, Takakuwa, Tetsuya, Imai, Shosuke, Shuin, Taro, Taguchi, Hirokuni, Daibata, Masanori, Nemoto, Yuiko, Bandobashi, Kentaro, Kotani, Norihiro, Kuroda, Masayuki, Tsuchiya, Mutsumi, Okuda, Heiwa, Takakuwa, Tetsuya, Imai, Shosuke, Shuin, Taro, and Taguchi, Hirokuni

Published
2018

20. Prognostic Factors for Chronic Active Epstein-Barr Virus Infection

Author

Kimura, Hiroshi, Morishima, Tsuneo, Kanegane, Hirokazu, Ohga, Shouichi, Hoshino, Yo, Maeda, Akihiko, Imai, Shosuke, Okano, Motohiko, Morio, Tomohiro, Yokota, Shumpei, Tsuchiya, Shigeru, Yachie, Akihiro, Imashuku, Shinsaku, Kawa, Keisei, Wakiguchi, Hiroshi, Members, of the Japanese Association for Research on Epstein-Barr Virus and Related Diseases, Kimura, Hiroshi, Morishima, Tsuneo, Kanegane, Hirokazu, Ohga, Shouichi, Hoshino, Yo, Maeda, Akihiko, Imai, Shosuke, Okano, Motohiko, Morio, Tomohiro, Yokota, Shumpei, Tsuchiya, Shigeru, Yachie, Akihiro, Imashuku, Shinsaku, Kawa, Keisei, Wakiguchi, Hiroshi, and Members, of the Japanese Association for Research on Epstein-Barr Virus and Related Diseases

Published
2018

23. Interferon-α/β receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006

Author

Wakiguchi Hiroshi, Imai Shosuke, Hashimoto Noriko, Batchelor Jonathan, Homma Toshiki, Kato Atsushi, Saito Hirohisa, and Matsumoto Kenji

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODN) are known to exert a strong adjuvant effect on Th1 immune responses. Although several genes have been reported, no comprehensive study of the gene expression profiles in human cells after stimulation with CpG ODN has been reported. Results This study was designed to identify a CpG-inducible gene cluster that potentially predicts for the molecular mechanisms of clinical efficacy of CpG ODN, by determining mRNA expression in human PBMC after stimulation with CpG ODN. PBMCs were obtained from the peripheral blood of healthy volunteers and cultured in the presence or absence of CpG ODN 2006 for up to 24 hours. The mRNA expression profile was evaluated using a high-density oligonucleotide probe array, GeneChip®. Using hierarchical clustering-analysis, out of a total of 10,000 genes we identified a cluster containing 77 genes as having been up-regulated by CpG ODN. This cluster was further divided into two sub-clusters by means of time-kinetics. (1) Inflammatory cytokines such as IL-6 and GM-CSF were up-regulated predominantly 3 to 6 hours after stimulation with CpG ODN, presumably through activation of a transcription factor, NF-κB. (2) Interferon (IFN)-inducible anti-viral proteins, including IFIT1, OAS1 and Mx1, and Th1 chemoattractant IP-10, were up-regulated predominantly 6 to 24 hours after stimulation. Blocking with mAb against IFN-α/β receptor strongly inhibited the induction of these IFN-inducible genes by CpG ODN. Conclusion This study provides new information regarding the possible immunomodulatory effects of CpG ODN in vivo via an IFN-α/β receptor-mediated paracrine pathway.

Published
2003
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24. Expression of myeloid cell phenotypes by a novel adult T-cell leukemia/lymphoma cell line

Author

Koizumi, Shigeki, Iwanaga, Michiyo, Imai, Shosuke, Yamashiro, Katsushige, Mikuni, Chikara, Abe, Shuichi, Kakinuma, Mitsuaki, Saito, Nagahito, Takami, Tsuyoshi, Fukazawa, Yuichiro, Miwa, Masanao, and Osato, Toyoro

Subjects
HTLV-I (Virus), Cell lines, Phenotype -- Physiological aspects, Health
Abstract

Background: Human T-cell leukemia virus type 1 (HTLV -1) can infect a number of cells of different lineages in vitro, yet the immunophenotypes of most adult T-cell leukemia/lymphomas (ATLs) are restricted to [CD4.sup.+). The apparent discrepancy between these findings is still largely unknown. Purpose: We report on a unique case of ATL in which the leukemia cells were positive for both T-cell and myeloid cell antigens. To characterize these cells, we isolated cell lines from this patient with ATL. Methods: The fresh leukemia cells were cultured without the addition of interleukin-2. Cell cloning was carried out by limiting dilution. Results: A cell line (MU) and its clonal sublines were established. MU cells showed the same chromosomal abnormalities and T-cell receptor [beta-chain] gene rearrangement pattern as those of fresh leukemia cells. MU cells were exclusively positive for a myeloid cell marker, despite the presence of T-cell receptor gene rearrangement. Conclusion: The established ATL cell line showed both T-cell and myeloid cell characteristics, which seems to be the first evidence for the close association of ATL cells with both lymphoid and myeloid features. The cell line may provide a new insight for the targets of HTLV-1 infection and transformation in vivo. [J Natl Cancer Inst 84:690-693, 1992]

Published
1992

25. Characterization and comparison of two newly established Epstein-Barr virus (EBV)-negative and EBV-positive Burkitt's lymphoma cell lines: EBV-negative cell line with a low level of expression of ICAM-1 molecule and EBV-positive cell line with a high level of expression of ICAM-1 molecule

Author

Abe, Masafumi, Tasaki, Kazuhiro, Tominaga, Kunihiko, Fukuhara, Shiro, Imai, Shosuke, Osato, Toyoro, and Wakasa, Haruki

Subjects
Epstein-Barr virus diseases -- Physiological aspects, Burkitt's lymphoma -- Physiological aspects, Cell lines -- Research, Health
Published
1992

30. Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3

Author

Iwakiri, Dai, Zhou, Li, Samanta, Mrinal, Matsumoto, Misako, Ebihara, Takashi, Seya, Tsukasa, Imai, Shosuke, Fujieda, Mikiya, Kawa, Keisei, Takada, Kenzo, Iwakiri, Dai, Zhou, Li, Samanta, Mrinal, Matsumoto, Misako, Ebihara, Takashi, Seya, Tsukasa, Imai, Shosuke, Fujieda, Mikiya, Kawa, Keisei, and Takada, Kenzo

Abstract

Epstein-Barr virus-encoded small RNA (EBER) is nonpolyadenylated, noncoding RNA that forms stem-loop structure by intermolecular base-pairing, giving rise to double-stranded RNA (dsRNA)-like molecules, and exists abundantly in EBV-infected cells. Here, we report that EBER induces signaling from the Toll-like receptor 3 (TLR3), which is a sensor of viral double-stranded RNA (dsRNA) and induces type I IFN and proinflammatory cytokines. A substantial amount of EBER, which was sufficient to induce signaling from TLR3, was released from EBV-infected cells, and the majority of the released EBER existed as a complex with a cellular EBER-binding protein La, suggesting that EBER was released from the cells by active secretion of La. Sera from patients with infectious mononucleosis (IM), chronic active EBV infection (CAEBV), and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH), whose general symptoms are caused by proinflammatory cytokines contained EBER, and addition of RNA purified from the sera into culture medium induced signaling from TLR3 in EBV-transformed lymphocytes and peripheral mononuclear cells. Furthermore, DCs treated with EBER showed mature phenotype and antigen presentation capacity. These findings suggest that EBER, which is released from EBV-infected cells, is responsible for immune activation by EBV, inducing type I IFN and proinflammatory cytokines. EBER-induced activation of innate immunity would account for immunopathologic diseases caused by active EBV infection.

Published
2009

34. Regulation of IL-27p28 gene by lipopolysaccharide in dendritic DC2.4 cells

Author

Kamakura, Maki, primary, Morisawa, Keiko, additional, Komi, Hideyuki, additional, Tomatani, Ayako, additional, Saito, Fumiji, additional, Konishi, Yuko, additional, Jin, Ya, additional, Manabe, Takashi, additional, Kuroda, Masayuki, additional, Imai, Shosuke, additional, Mizuguchi, Hiroyuki, additional, and Taniguchi, Taketoshi, additional

Published
2006
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37. Eradication of epstein–barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1

Author

Nasimuzzaman, Md., primary, Kuroda, Masayuki, additional, Dohno, Sumitaka, additional, Yamamoto, Takenobu, additional, Iwatsuki, Keiji, additional, Matsuzaki, Shigenobu, additional, Mohammad, Rashel, additional, Kumita, Wakako, additional, Mizuguchi, Hiroyuki, additional, Hayakawa, Takao, additional, Nakamura, Hiroyuki, additional, Taguchi, Takahiro, additional, Wakiguchi, Hiroshi, additional, and Imai, Shosuke, additional

Published
2005
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39. Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection

Author

Okano, Motohiko, primary, Kawa, Keisei, additional, Kimura, Hiroshi, additional, Yachie, Akihiro, additional, Wakiguchi, Hiroshi, additional, Maeda, Akihiko, additional, Imai, Shosuke, additional, Ohga, Shouichi, additional, Kanegane, Hirokazu, additional, Tsuchiya, Shigeru, additional, Morio, Tomohiro, additional, Mori, Masaaki, additional, Yokota, Shumpei, additional, and Imashuku, Shinsaku, additional

Published
2005
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44. Experimental Protection of Mice against LethalStaphylococcus aureusInfection by Novel Bacteriophage φMR11

Author

Matsuzaki, Shigenobu, primary, Yasuda, Masaharu, additional, Nishikawa, Hiroshi, additional, Kuroda, Masayuki, additional, Ujihara, Takako, additional, Shuin, Taro, additional, Shen, Yuan, additional, Jin, Zhe, additional, Fujimoto, Shigeyoshi, additional, Nasimuzzaman, M. D., additional, Wakiguchi, Hiroshi, additional, Sugihara, Shigeyoshi, additional, Sugiura, Tetsuro, additional, Koda, Shigeki, additional, Muraoka, Asako, additional, and Imai, Shosuke, additional

Published
2003
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46. PEBP2αA/CBFA1 mutations in Japanese cleidocranial dysplasia patients

Author

Zhang, Yu-Wen, primary, Yasui, Natsuo, additional, Kakazu, Naoki, additional, Abe, Tatsuo, additional, Takada, Kenzo, additional, Imai, Shosuke, additional, Sato, Motohiko, additional, Nomura, Shintaro, additional, Ochi, Takahiro, additional, Okuzumi, Shigeharu, additional, Nogami, Hiroshi, additional, Nagai, Toshiro, additional, Ohashi, Hirohumi, additional, and Ito, Yoshiaki, additional

Published
2000
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