2,571 results on '"Imaging Division"'
Search Results
2. Ketamine Treatment Effects on Synaptic Plasticity in Depression
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Jeffrey Miller, Director of Brain Imaging, Division of Molecular Imaging and Neuropathology
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- 2023
3. Piecewise-Constant-Model-Based Interior Tomography Applied to Dentin Tubules
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Wang, Ge [Biomedical Imaging Division, VT-WFU School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA, Biomedical Imaging Division, VT-WFU School of Biomedical Engineering and Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA] (ORCID:0000000226567705)
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- 2013
- Full Text
- View/download PDF
4. Non-invasive Cardiac Screening in High Risk Patients -The GROUND Study
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Clinical Research Office Imaging Division, Clinical research coordinator
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- 2018
5. Follow-up of Endovascular Aneurysm Treatment - The FEAT Trial
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Clinical Research Office Imaging Division, Clinical research coordinator
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- 2018
6. VERTOS-II. Percutaneous Vertebroplasty Versus Conservative Therapy
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ZonMw: The Netherlands Organisation for Health Research and Development and Clinical Research Office Imaging Division, Clinical research coordinator
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- 2018
7. SU-F-J-63: Abdominal Diameter Changes in Children During Volumetric Modulated Arc Therapy (VMAT): Is Re-Planning Needed?
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Raaymakers, B [University Medical Center Utrecht, Department of Radiotherapy and Imaging Division, Utrecht (Netherlands)]
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- 2016
- Full Text
- View/download PDF
8. Report on the Clinical Outcomes of Permanent Breast Seed Implant for Early-Stage Breast Cancers
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Verkooijen, Helena [Imaging Division, University Medical Centre Utrecht, Utrecht (Netherlands)]
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- 2015
- Full Text
- View/download PDF
9. Combining Multi-Task Learning and Multi-Channel Variational Auto-Encoders to Exploit Datasets with Missing Observations -Application to Multi-Modal Neuroimaging Studies in Dementia
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ANTELMI, Luigi, AYACHE, Nicholas, ROBERT, Philippe, RIBALDI, Federica, GARIBOTTO, Valentina, FRISONI, Giovanni, LORENZI, Marco, E-Patient : Images, données & mOdèles pour la médeciNe numériquE (EPIONE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Cognition Behaviour Technology (CobTek), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice)-Université Côte d'Azur (UCA), Centre Mémoire de Ressources et de Recherche [Nice] (CMRR Nice), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), IRCCS Fatebenefratelli - Brescia, Università degli Studi di Brescia = University of Brescia (UniBs), Laboratory of Alzheimer’s Neuroimaging and Epidemiology (LANE), Saint John of God Clinical Research Centre, Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMT-lab), Geneva University Hospital (HUG), Nuclear Medicine and Molecular Imaging Division, Laboratory of Neuroimaging of aging, Memory clinic and LANVIE, Geneva University Hospital and Geneva University, ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019), Université Côte d'Azur (UCA)-Institut Claude Pompidou [Nice] (ICP - Nice)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), Università degli Studi di Brescia [Brescia], ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI (2016), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice), Université Côte d'Azur (UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), and COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)
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[STAT]Statistics [stat] ,[INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG] ,Missing Data ,Multi Task Learning ,Variational Autoencoders ,Multimodal Data Analysis ,OPAL-Meso - Abstract
The joint modeling of neuroimaging data across multiple datasets requires to consistently analyze high-dimensional and heterogeneous information in presence of often non-overlapping sets of views across data samples (e.g. imaging data, clinical scores, biological measurements). This analysis is associated with the problem of missing information across datasets, which can happen in two forms: missing at random (MAR), when the absence of a view is unpredictable and does not depend on the dataset (e.g. due to data corruption); missing not at random (MNAR), when a specific view is absent by design for a specific dataset. In order to take advantage of the increased variability and sample size when pooling together observations from many cohorts and at the same time cope with the ubiquitous problem of missing information, we propose here a multi-task generative latent-variable model where the common variability across datasets stems from the estimation of a shared latent representation across views. Our formulation allows to retrieve a consistent latent representation common to all views and datasets, even in the presence of missing information. Simulations on synthetic data show that our method is able to identify a common latent representation of multi-view datasets, even when the compatibility across datasets is minimal. When jointly analyzing multi-modal neuroimaging and clinical data from real independent dementia studies, our model is able to mitigate the absence of modalities without having to discard any available information. Moreover, the common latent representation inferred with our model can be used to define robust classifiers gathering the combined information across different datasets. To conclude, both on synthetic and real data experiments, our model compared favorably to state of the art benchmark methods, providing a more powerful exploitation of multi-modal observations with missing views.
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- 2021
10. Breast-Gynaecological & Immuno-Oncology International Cancer Conference (BGICC) Consensus and Recommendations for the Management of Triple-Negative Breast Cancer
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Jessica W.T. Leung, Sana Al-Sukhun, Omalkhair Abulkhair, Benjamin O. Anderson, Meteb Foheidi, Nagi S. El Saghir, Hany Abdel Aziz, Joseph Gligorov, Mohamed Sabry, Hamdy A. Azim, Hagar Elghazawy, Edith A. Perez, Frédérique Penault-Llorca, Bahadir M. Gulluoglu, Joaira Bakkach, Khaled Abdel Karim, Banu Arun, Pierfranco Conte, Valentina Guarneri, Hope S. Rugo, Hesham Elghazaly, Mohamed A Shehata, Mona Frolova, Philip Poortmans, Cheng Har Yip, Sandra M. Swain, Manal Mohamed El-mahdy, Nermean Bahie Eldin, Alaa Kandil, Mohamed El-Shinawi, Charles M. Balch, Marwan Ghosn, Wentao Yang, Matti Aapro, Heba M. El-Zawahry, Adel T. Aref, Armando E. Giuliano, Roberto Orecchia, Ruslan M. Paltuev, Ain Shams University (ASU), Department of Medicine, University of California San Francisco Comprehensive Cancer Center, San Francisco, CA 94158, Clinical Oncology Department, Kasr Alainy School of Medicine, Cairo University, Giza 12613, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, MedStar Health, Washington, DC 20007, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, Breast Center, Clinique de Genolier, 1272 Genolier, Department of Hematology & Oncology, Mayo Clinic, Jacksonville, FL 32224, University of Washington [Seattle], Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Department of Surgery, Oncology and Gastroenterology, University of Padova, Istituto Oncologico Veneto IOV IRCCS, 35128 Padova, Department of Internal Medicine, Division of Hematology Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Subang Jaya Medical Centre, Kuala Lumpur 47500, Université Saint-Joseph de Beyrouth (USJ), University of Antwerp (UA), Clinical oncology Department, Menoufia University, Shebin Elkom 51132, Department of Surgery, Surgical Oncology Division, Cedars-Sinai Medical Center, Los Angeles, CA 90048, Department of Breast Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Breast & Endocrine Surgery Unit, Marmara University School of Medicine, University Hospital, Istanbul 34722, Federal State Budgetary Institution 'NN Blokhin National Medical Research Center of Oncology' of the Ministry of Health of the Russian Federation, 127994 Moscow, Surgical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, Università degli Studi di Milano = University of Milan (UNIMI), Al Hyatt Oncology Practice, Amman 11183, Department of Clinical Oncology, Alexandria School of Medicine, Alexandria 21131, Russian Association of Oncological Mammology, Department of Breast Tumours of Federal State Budgetary Institution 'Petrov Research Institute of Oncology', 197758 Saint Petersburg, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Adult Medical Oncology, Princess Noorah Oncology Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs-Western Region, Jeddah 22384, Vice President of Galala University, Galala University, Suez 435611, Oncology Department, Alfaisal university, Alhabib Hospital, Riyad 11533, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, University of Adelaide, Biomedical Genomics & Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, Abdel Malek Essaadi University, Tangier 90000, Elghazaly, Hesham, Rugo, Hope S., Azim, Hamdy A., Swain, Sandra M., Arun, Banu, Aapro, Matti, Perez, Edith A., Anderson, Benjamin O., Penault-Llorca, Frederique, Conte, Pierfranco, El Saghir, Nagi S., Yip, Cheng-Har, Ghosn, Marwan, Poortmans, Philip, Shehata, Mohamed A., Giuliano, Armando E., Leung, Jessica W. T., Guarneri, Valentina, Gligorov, Joseph, Gulluoglu, Bahadir M., Abdel Aziz, Hany, Frolova, Mona, Sabry, Mohamed, Balch, Charles M., Orecchia, Roberto, El-Zawahry, Heba M., Al-Sukhun, Sana, Abdel Karim, Khaled, Kandil, Alaa, Paltuev, Ruslan M., Foheidi, Meteb, El-Shinawi, Mohamed, ElMahdy, Manal, Abulkhair, Omalkhair, Yang, Wentao, Aref, Adel T., Bakkach, Joaira, Bahie Eldin, Nermean, Elghazawy, Hagar, Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo 11566, Breast Health Global Initiative, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98195, Hematology and Oncology Department, Saint Joseph University, Beirut 1104 2020, Iridium Kankernetwerk and Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk-Antwer, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Scientific Directorate, IRCCS European Institute of Oncology (IEO), and University of Milan, 20122 Milan, Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo 11566, Department of Pathology, Ain shams University, Cairo 11566, and The School of Public Health, University of Adelaide, Adelaide 5005
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,POSTMASTECTOMY RADIOTHERAPY ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,education ,COMPLETE RESPONSE PCR ,Disease ,MUTATION CARRIERS ,Guidelines ,03 medical and health sciences ,NEOADJUVANT CHEMOTHERAPY ,0302 clinical medicine ,Breast cancer ,ADJUVANT CHEMOTHERAPY ,medicine ,DISEASE-FREE SURVIVAL ,TUMOR-INFILTRATING LYMPHOCYTES ,platinum ,LOCOREGIONAL RECURRENCE ,AMERICAN SOCIETY ,Triple-negative breast cancer ,RC254-282 ,business.industry ,BRCA mutations ,Consensus ,Immunotherapy ,Platinum ,Cancer conference ,Consensus conference ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Evidence-based medicine ,RANDOMIZED PHASE-III ,medicine.disease ,3. Good health ,Clinical trial ,030104 developmental biology ,Oncology ,consensus ,030220 oncology & carcinogenesis ,Family medicine ,triple-negative breast cancer ,Human medicine ,immunotherapy ,business ,Mastectomy - Abstract
Simple Summary Despite the impressive progress in the treatment of triple-negative breast cancer (TNBC), oncologists still face several provocative clinical scenarios in daily practice where clear evidence-based recommendations are lacking, and expert opinion is of utmost importance. In an attempt to seek guidance for these controversial topics in TNBC management, a consensus recommendations session for TNBC was held during the 12th round of the Breast-Gynaecological & Immuno-oncology International Cancer Conference (BGICC) Egypt, 2020. This special session convened a multidisciplinary committee of 35 panellists who specialize in breast cancer care from 13 countries. The consensus covered all the aspects of TNBC management starting from defining TNBC to the management of metastatic disease and highlighted the rapidly evolving landscape in this field. Consensus was reached in 70% of the statements (35/50). In addition, areas of warranted research were identified to guide future prospective clinical trials. Background: The management of patients with triple-negative breast cancer (TNBC) is challenging with several controversies and unmet needs. During the 12th Breast-Gynaecological & Immuno-oncology International Cancer Conference (BGICC) Egypt, 2020, a panel of 35 breast cancer experts from 13 countries voted on consensus guidelines for the clinical management of TNBC. The consensus was subsequently updated based on the most recent data evolved lately. Methods: A consensus conference approach adapted from the American Society of Clinical Oncology (ASCO) was utilized. The panellists voted anonymously on each question, and a consensus was achieved when >= 75% of voters selected an answer. The final consensus was later circulated to the panellists for critical revision of important intellectual content. Results and conclusion: These recommendations represent the available clinical evidence and expert opinion when evidence is scarce. The percentage of the consensus votes, levels of evidence and grades of recommendation are presented for each statement. The consensus covered all the aspects of TNBC management starting from defining TNBC to the management of metastatic disease and highlighted the rapidly evolving landscape in this field. Consensus was reached in 70% of the statements (35/50). In addition, areas of warranted research were identified to guide future prospective clinical trials.
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- 2021
11. Ureteric Embolization for Lower Urinary Tract Fistulae: Use of Two Amplatzer Vascular Plugs and N-Butyl Cyanoacrylate Employing the 'Sandwich' Technique
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Matsumoto, A. [University of Virginia Health System, Department of Radiology and Medical Imaging, Division of Vascular Interventional Radiology (United States)]
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- 2013
- Full Text
- View/download PDF
12. Higher-order phase shift reconstruction approach
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Ge, Wang [Biomedical Imaging Division, School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States)]
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- 2010
- Full Text
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13. Endovenous Laser Ablation of the Small Saphenous Vein Sparing the Saphenopopliteal Junction
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Davison, Brian [Massachusetts General Hospital-Harvard Medical School, Department of Imaging, Division of Vascular Imaging and Intervention (United States)]
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- 2010
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- View/download PDF
14. FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas
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Eilber, Fritz [Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA, Division of Surgical Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA]
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- 2010
- Full Text
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15. CIRSE Standards of Practice on Bronchial Artery Embolisation
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Joachim Kettenbach, Harald Ittrich, Jean Yves Gaubert, Bernhard Gebauer, Jan Albert Vos, Département de Radiologie [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire d'Imagerie Interventionnelle Expérimentale (LIIE), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Européen de Recherche en Imagerie médicale (CERIMED), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS), Department of Radiology, Charité–Universitätsmedizin Berlin, Imaging Division [Utrecht, The Netherlands] (UMC), and University Medical Center [Utrecht]
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Lifethreatening haemoptysis ,Hemoptysis ,Bronchial artery ,[SDV]Life Sciences [q-bio] ,Haemoptysis ,Embolisation ,Bronchial Arteries ,Reference Standards ,Embolization, Therapeutic ,Massive haemoptysis ,Humans ,Radiology, Nuclear Medicine and imaging ,Endovascular treatment ,Cardiology and Cardiovascular Medicine ,Vascular Surgical Procedures - Abstract
This CIRSE Standards of Practice document is aimed at interventional radiologists and provides best practices for performing bronchial artery embolisation to effectively treat haemoptysis. It has been developed by an expert writing group established by the CIRSE Standards of Practice Committee.
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- 2020
16. Distal Embolic Protection for Renal Arterial Interventions
- Author
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Murphy, Timothy [Brown University Medical School, Department of Diagnostic Imaging, Division of Interventional Radiology (United States)]
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- 2008
- Full Text
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17. Non-rigid CT/CBCT to CBCT registration for online external beam radiotherapy guidance
- Author
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Zachiu, Cornel, Denis De Senneville, Baudouin, Tijssen, Rob, Kotte, Alexis, Houweling, Antonetta, Kerkmeijer, Linda, Lagendijk, Jan, Moonen, Chrit, Ries, Mario, University Medical Center [Utrecht], Imagerie moléculaire et fonctionnelle: de la physiologie à la thérapie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Centre National de la Recherche Scientifique (CNRS), Imaging Division, and Denis De Senneville, Baudouin
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Image-guided radiotherapy ,CT/CBCT registration ,Online guidance ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing - Abstract
International audience; Image-guided external beam radiotherapy (EBRT) allows radiation dose deposition with a high degree of accuracy and precision. Guidance is usually achieved by estimating the displacements, via image registration, between cone beam computed tomography (CBCT) and computed tomography (CT) images acquired at different stages of the therapy. The resulting displacements are then used to reposition the patient such that the location of the tumor at the time of treatment matches its position during planning. Moreover, ongoing research aims to use CBCT-CT image registration for online plan adaptation. However, CBCT images are usually acquired using a small number of X-Ray projections and/or low beam intensities. This often leads to the images being subject to low contrast, low signal-to-noise ratio and artifacts, which ends-up hampering the image registration process. Previous studies addressed this by integrating additional image processing steps into the registration procedure. However, these steps are usually designed for particular image acquisition schemes, therefore limiting their use on a case-by-case basis. In the current study we address CT to CBCT and CBCT to CBCT registration by the means of the recently proposed EVolution registration algorithm. Contrary to previous approaches, EVolution does not require the integration of additional image processing steps in the registration scheme. Moreover, the algorithm requires a low number of input parameters, is easily parallelizable and provides an elastic deformation on a point-by-point basis. Results have shown that for typical CBCT images, the intrinsic image artifacts only have a sub-millimeter impact on the accuracy and precision of the estimated deformation. In addition, the algorithm has low computational requirements, which are compatible with online image-based guidance of EBRT treatments.
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- 2018
18. Microbubble-Assisted Ultrasound-Induced Transient Phosphatidylserine Translocation
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Bart H. A. Lammertink, Jean-Michel Escoffre, Clemens Bos, Marc Derieppe, Chrit T. W. Moonen, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT), Imaging Division [Utrecht, The Netherlands] (UMC), University Medical Center [Utrecht], This work was supported by European Research Council Advanced Grant 268906 for the Sound Pharma project (C.M.)., Escoffre, Jean-Michel, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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0301 basic medicine ,Phospholipid scramblase ,[SDV.BIO]Life Sciences [q-bio]/Biotechnology ,Acoustics and Ultrasonics ,Cell Survival ,Membrane permeabilization ,Sulfur Hexafluoride ,Biophysics ,Contrast Media ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Phosphatidylserines ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Endocytosis ,Permeability ,Exocytosis ,Microbubble ,03 medical and health sciences ,chemistry.chemical_compound ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Annexin ,Ultrasound ,medicine ,Journal Article ,Animals ,Radiology, Nuclear Medicine and imaging ,Viability assay ,Cell damage ,[SDV.BC] Life Sciences [q-bio]/Cellular Biology ,Phospholipids ,Microbubbles ,Radiological and Ultrasound Technology ,Glioma ,Phosphatidylserine ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,medicine.disease ,Rats ,[SDV.BIO] Life Sciences [q-bio]/Biotechnology ,[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences ,Phosphatidylserine externalization ,030104 developmental biology ,Membrane ,Ultrasonic Waves ,chemistry - Abstract
International audience; Microbubble-assisted ultrasound (sonopermeabilization) results in reversible permeabilization of the plasma membrane of cells. This method is increasingly used in vivo because of its potential to deliver therapeutic molecules with limited cell damage. Nevertheless, the effects of sonopermeabilization on the plasma membrane remain not fully understood. We investigated the influence of sonopermeabilization on the transverse mobility of phospholipids, especially on phosphatidylserine (PS) externalization. We performed studies using optical imaging with Annexin V and FM1-43 probes to monitor PS externalization of rat glioma C6 cells. Sonopermeabilization induced transient membrane permeabilization, which is positively correlated with reversible PS externalization. This membrane disorganization was temporary and not associated with loss of cell viability. Sonopermeabilization did not induce PS externalization via activation of the scramblase. We hypothesize that acoustically induced membrane pores may provide a new pathway for PS migration between both membrane leaflets. During the membrane-resealing phase, PS asymmetry may be re-established by amino-phospholipid flippase activity and/or endocytosis, along with exocytosis processes.
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- 2017
19. A Direct PCA-Based Approach for Real-Time Description of Physiological Organ Deformations
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Chrit T. W. Moonen, Baudouin Denis de Senneville, Abdallah El Hamidi, Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 (LaSIE), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS), Imaging Division, and University Medical Center [Utrecht]
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Motion analysis ,Computer science ,Movement ,Optical flow ,Image processing ,Kidney ,Research Support ,INTENSITY FOCUSED ULTRASOUND ,THERAPY ,030218 nuclear medicine & medical imaging ,Rendering (computer graphics) ,Machine Learning ,03 medical and health sciences ,0302 clinical medicine ,Organ Motion ,Motion estimation ,Image Processing, Computer-Assisted ,Journal Article ,Humans ,Computer vision ,Electrical and Electronic Engineering ,Non-U.S. Gov't ,Lung ,ABDOMINAL ORGANS ,Principal Component Analysis ,Radiological and Ultrasound Technology ,business.industry ,OPTICAL-FLOW ,Research Support, Non-U.S. Gov't ,MOTION CORRECTION ,Heart ,MR-THERMOMETRY ,Magnetic Resonance Imaging ,Computer Science Applications ,030220 oncology & carcinogenesis ,Principal component analysis ,real-time system ,Artificial intelligence ,business ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,Algorithms ,Software - Abstract
Dynamic magnetic resonance (MR)-imaging can provide functional and positional information in real-time, which can be conveniently used online to control a cancer therapy, e. g., using high intensity focused ultrasound or radio therapy. However, a precise real-time correction for motion is fundamental in abdominal organs to ensure an optimal treatment dose associated with a limited toxicity in nearby organs at risk. This paper proposes a real-time direct principal component analysis (PCA)-based technique which offers a robust approach for motion estimation of abdominal organs and allows correcting motion related artifacts. The PCA was used to detect spatio-temporal coherences of the periodic organ motion in a learning step. During the interventional procedure, physiological contributions were characterized quantitatively using a small set of parameters. A coarse-to-fine resolution scheme is proposed to improve the stability of the algorithm and afford a predictable constant latency of 80 ms. The technique was evaluated on 12 free-breathing volunteers and provided an improved real-time description of motion related to both breathing and cardiac cycles. A reduced learning step of 10 s was sufficient without any need for patient-specific control parameters, rendering the method suitable for clinical use.
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- 2015
20. Development of a tumor tissue-mimicking model with endothelial cell layer and collagen gel for evaluating drug penetration
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Sasaki, Noboru, Bos, Clemens, Escoffre, Jean Michel, Storm, G, Moonen, Chrit, Sub Drug targeting, Pharmaceutics, Biomaterials Science and Technology, Faculty of Science and Technology, Escoffre, Jean-Michel, Imaging Division [Utrecht, The Netherlands] (UMC), University Medical Center [Utrecht], Department of Pharmaceutics [Utrecht, Netherlands] (UIPS), Utrecht University [Utrecht], MIRA Institute for Biomedical Technology and Technical Medicine [Maastricht, Netherlands], This work was supported by Advanced ERC grant Sound Pharma – 268906 (CM)., Sub Drug targeting, and Pharmaceutics
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Pathology ,medicine.medical_specialty ,METIS-315204 ,Stromal cell ,[SDV.BIO]Life Sciences [q-bio]/Biotechnology ,DOXORUBICIN ,Endothelial layer ,Pharmaceutical Science ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Research Support ,Models, Biological ,THERAPY ,Collagen Type I ,Extracellular matrix ,BLOOD-VESSELS ,Sonication ,DELIVERY ,Interstitial matrix ,Cell Line, Tumor ,Neoplasms ,medicine ,Human Umbilical Vein Endothelial Cells ,Journal Article ,Humans ,PERMEABILITY ,Non-U.S. Gov't ,[SDV.BC] Life Sciences [q-bio]/Cellular Biology ,Chemistry ,Research Support, Non-U.S. Gov't ,Dextrans ,Penetration (firestop) ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,SOLID TUMORS ,MICROBUBBLES ,Coculture Techniques ,3. Good health ,[SDV.BIO] Life Sciences [q-bio]/Biotechnology ,Endothelial stem cell ,[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences ,IR-99931 ,Cell culture ,Cancer cell ,Drug delivery ,Drug penetration ,Biophysics ,Tissue-mimicking model ,Fluorescein-5-isothiocyanate - Abstract
International audience; The endothelial cells of vessels, the interstitial matrix and the distance between the tumor cells and vessels, are the major penetration barriers for intravenously administered anticancer drugs in reaching tumor cells after intravenous injection. The availability of a tumor tissue-mimicking model that includes both the endothelial cell layer and the extracellular matrix would be beneficial to assess drug penetration in early stages of drug development. Here, we propose a novel in vitro model for studying the above mentioned barriers. Human umbilical vein endothelial cells were cultured as a single layer on a collagen type-I coated permeable cell culture insert. After culturing for five days, the insert was superimposed on collagen type-I gel containing cancer cells. The system was evaluated for assessing penetration-enhancement by ultrasound triggered microbubble cavitation. Our model allowed visualization of the penetration distance of a model drug (fluorescein isothiocyanate-Dextran 500000-conjugated, FD500) from the endothelial cell layer into the cancer cell containing collagen matrix upon different sonication treatments. Initial results showed that the model allows the visualization of drug penetration and that the endothelial cell layer is affecting this. The presented in vitro model aims to mimic vessels and stromal tissue in cancer, and thus can aid in the assessment of drug penetration in the case of tumor-targeted drug delivery, and in the reduction and refinement of animal studies. 2015 Published by Elsevier B.V.
- Published
- 2015
21. Rapid Dynamic Temperature/R1/R2* Assessment : A Method With Potential For Monitoring Drug Delivery
- Author
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Lorenzato, Cyril, Oerlemans, Chris, Cernicanu, Alexandru, Ries, Mario, Denis De Senneville, Baudouin, Moonen, Chrit, Bos, Clemens, Imaging Division, University Medical Center [Utrecht], MedisysResearch Lab (Medisys), Philips Research, Institut de Mathématiques de Bordeaux (IMB), and Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2014
22. Motion Correction Techniques for MR-Guided HIFU Ablation of Abdominal Organs
- Author
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Sébastien Roujol, Chrit Moonen, Baudouin Denis de Senneville, Imagerie moléculaire et fonctionnelle: de la physiologie à la thérapie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Centre National de la Recherche Scientifique (CNRS), Harvard Medical School [Boston] (HMS), Imaging Division, University Medical Center [Utrecht], Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), and Image sciences institute - University of Utrecht (ISI)
- Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing - Published
- 2014
23. Combined Magnetic Resonance and Ultrasound Echography Guidance for direct and indirect motion tracking
- Author
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Denis De Senneville, Baudouin, Regard, Yvan, Moonen, Chrit, Ries, Mario, Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Imaging Division, University Medical Center [Utrecht], Imagerie moléculaire et fonctionnelle: de la physiologie à la thérapie, and Université Bordeaux Segalen - Bordeaux 2-IFR8-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2014
24. Real-time anticipation of organ displacement for MR-guidance of interventional procedures
- Author
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B. Denis de Senneville, Mario Ries, Chrit T. W. Moonen, Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Imaging Division, and University Medical Center [Utrecht]
- Subjects
Kidney ,medicine.diagnostic_test ,Computer science ,business.industry ,Image registration ,Magnetic resonance imaging ,Kalman filter ,Displacement (vector) ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,medicine ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Abdomen ,Computer vision ,Artificial intelligence ,business ,Image resolution ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,030217 neurology & neurosurgery ,ComputingMilieux_MISCELLANEOUS - Abstract
Modern Magnetic Resonance Imaging (MRI) methods now allow the rapid acquisition of images with an excellent tissue contrast and high spatial resolution. Complex organ deformations can thus be estimated using image registration techniques applied to anatomical information. This opens great perspectives for the use of MRI to retroactively target an interventional procedure in mobile organs in real-time. For this purpose, both the update time and the latency of the motion information are two key points. In the current paper, the organ deformation is estimated on a voxel-by-voxel basis and a Kalman predictor is used to compensate for the residual latency. The implementation benefitted from the parallel architecture of Graphical Processing Units (GPU) for accelerating computation times. The efficiency and the potential of the method to anticipate organ displacements in real-time was evaluated on the abdomen of twelve free-breathing volunteers. The deformation of both kidney and liver could be updated with a rate of 10 Hz over sustained periods of several minutes, and the employed Kalman predictor reduced the tracking error in average by 30%.
- Published
- 2013
25. MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image guided local drug delivery
- Author
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Lorenzato, Cyril, Cernicanu, Alexandru, Meyre, Marie-Edith, Germain, Matthieu, Pottier., Agnès, Levy, Laurent, Denis de Senneville, Baudouin, Bos, Clemens, Moonen, Chrit, Smirnov, Pierre, Imaging Division, University Medical Center [Utrecht], MedisysResearch Lab (Medisys), Philips Research, Nanobiotix, and Denis De Senneville, Baudouin
- Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,[INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing ,[INFO.INFO-IM] Computer Science [cs]/Medical Imaging ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,ComputingMilieux_MISCELLANEOUS ,[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing - Abstract
International audience
- Published
- 2013
26. Real-Time Assessment of Ultrasound-Mediated Drug Delivery Using Fibered Confocal Fluorescence Microscopy
- Author
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Baudouin Denis de Senneville, Matthieu Lepetit-Coiffé, Anna Yudina, Chrit T. W. Moonen, Marc Derieppe, Clemens Bos, Imaging Division, University Medical Center [Utrecht], Imagerie moléculaire et fonctionnelle: de la physiologie à la thérapie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Centre National de la Recherche Scientifique (CNRS), Institut de Mathématiques de Bordeaux (IMB), and Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)
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Cancer Research ,Biological barrier ,Cell Membrane Permeability ,Confocal ,Fibered confocal fluorescence microscopy ,Population ,SYTOX ,US-mediated drug delivery ,Models, Biological ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Drug Delivery Systems ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,Cell Line, Tumor ,Microscopy ,Ultrasound ,Fluorescence microscope ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Animals ,Humans ,Radiology, Nuclear Medicine and imaging ,Organic Chemicals ,education ,030304 developmental biology ,Ultrasonography ,0303 health sciences ,education.field_of_study ,Microbubbles ,Microscopy, Confocal ,Chemistry ,Plasma membrane permeabilization ,Fluorescence ,3. Good health ,Molecular Imaging ,Rats ,Kinetics ,Oncology ,Microscopy, Fluorescence ,Pharmacokinetic parameters ,Drug delivery ,Green ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,Intracellular ,bioeffects ,Biomedical engineering - Abstract
International audience; Purpose: Transport across the plasma membrane is a critical step of drug delivery for weakly permeable compounds with intracellular mode of action. The purpose of this study is to demonstrate real-time monitoring of ultrasound (US)-mediated cell-impermeable model drug uptake with fibered confocal fluorescence microscopy (FCFM). Procedures: An in vitro setup was designed to combine a mono-element US transducer, a cell chamber with a monolayer of tumor cells together with SonoVue microbubbles, and a FCFM system. The cell-impermeable intercalating dye, SYTOX Green, was used to monitor US-mediated uptake. Results: The majority of the cell population showed fluorescence signal enhancement 10 s after US onset. The mean rate constant k of signal enhancement was calculated to be 0.23±0.04 min −1. Conclusions: Feasibility of real-time monitoring of US-mediated intracellular delivery by FCFM has been demonstrated. The method allowed quantitative assessment of model drug uptake, holding great promise for further local drug delivery studies.
- Published
- 2013
27. Extended Kalman Filtering for Continuous Volumetric MR-Temperature Imaging
- Author
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S. Hey, Mario Ries, Sébastien Roujol, B. D. de Senneville, Chrit T. W. Moonen, Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Imagerie moléculaire et fonctionnelle: de la physiologie à la thérapie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Centre National de la Recherche Scientifique (CNRS), University Medical Center [Utrecht], and Imaging Division
- Subjects
Motion analysis ,Hot Temperature ,Computer science ,Swine ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Noise reduction ,Acoustics ,Image processing ,Thermometry ,computer.software_genre ,Kidney ,Imaging phantom ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Extended Kalman filter ,0302 clinical medicine ,Nuclear magnetic resonance ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,Voxel ,medicine ,Image Processing, Computer-Assisted ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Animals ,Electrical and Electronic Engineering ,Image resolution ,ComputingMilieux_MISCELLANEOUS ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Phantoms, Imaging ,Real time systems ,Magnetic resonance imaging ,Kalman filter ,Magnetic Resonance Imaging ,Computer Science Applications ,Data set ,Temporal resolution ,computer ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,030217 neurology & neurosurgery ,Software ,Algorithms - Abstract
International audience; Real time magnetic resonance (MR) thermometry has evolved into the method of choice for the guidance of high-intensity focused ultrasound (HIFU) interventions. For this role, MR-thermometry should preferably have a high temporal and spatial resolution and allow observing the temperature over the entire targeted area and its vicinity with a high accuracy. In addition, the precision of real time MR-thermometry for therapy guidance is generally limited by the available Signal to Noise ratio (SNR) and the influence of physiological noise. MR-guided HIFU would benefit of the large coverage volumetric temperature maps, including characterization of volumetric heating trajectories as well as near-and far-field heating. In this paper, continuous volumetric MR-temperature monitoring was obtained as follows: The targeted area was continuously scanned during the heating process by a multi-slice sequence. Measured data and a priori knowledge of 3D data derived from a forecast based on a physical model were combined using an Extended Kalman Filter (EKF). The proposed reconstruction improved the temperature measurement resolution and precision while maintaining guaranteed output accuracy. The method was evaluated experimentally ex-vivo on a phantom , and in-vivo on a porcine kidney, using HIFU heating. On the in-vivo experiment, it allowed the reconstruction from a spatio-temporally under-sampled data set (with an update rate for each voxel of 1.143 s) to a 3D dataset covering a field of view of 142.5×285×54 mm 3 with a voxel size of 3×3×6 mm 3 and a temporal resolution of 0.127 s. The method also provided noise reduction, while having a minimal impact on accuracy and latency.
- Published
- 2013
28. The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus
- Author
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Matt Eames, Mario Ries, Andreas Melzer, Young-sun Kim, Kevin Michael Sekins, Neal F. Kassell, Lian Zhang, Fangwei Ye, Alessandro Napoli, Arik Hananel, Wladyslaw Gedroyc, Yerucham Shapira, Jean-François Aubry, Joo Ha Hwang, Gail ter Haar, Chrit T. W. Moonen, Rares Salomir, Feng Wu, Sham Sokka, Heather Huff-Simonin, Kim Butts Pauly, Department of Radiation Oncology, University of Virginia, Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Radiological Sciences Laboratory [Stanford] (RSL), Department of Radiology [Stanford], Stanford Medicine, Stanford University-Stanford University-Stanford Medicine, Stanford University-Stanford University, Imaging Division, University Medical Center [Utrecht], Division of Radiotherapy and Imaging, The Institute of Cancer Research-Royal Marsden Hospital, Faculty of Medicine, Université de Genève = University of Geneva (UNIGE), Philips Healthcare, Ultrasound Innovations Applications, Siemens Healthcare, InSightec Ltd, Chongqing Haifu Medical Technology Co., Chongqing Haifu Medical Technology Co., Ltd, Focused Ultrasound Foundation, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Digestive Disease Center, University of Washington [Seattle], Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University, Clinical Center for Tumor Therapy, Second Affiliated Hospital of Chongqing University of Medical Sciences, Institute for Medical Science and Technology, University of Dundee, Department of Radiology, Sungkyunkwan University [Suwon] (SKKU), Department of Medicine, Imperial College London, Saint Mary's Hospital [London], St Mary's Hospital [London], BMC, Ed., University of Virginia [Charlottesville], Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), University of Geneva [Switzerland], and Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]
- Subjects
medicine.medical_specialty ,Uterine fibroids ,Focused ultrasound ,medicine.medical_treatment ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Review ,ddc:616.0757 ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Ultrasound ,Medicine ,Radiology, Nuclear Medicine and imaging ,business.industry ,Non-invasive surgery ,medicine.disease ,High-intensity focused ultrasound ,3. Good health ,Hifu treatment ,030220 oncology & carcinogenesis ,Radiology ,business ,Liver cancer ,Benign prostate ,High-intensity ultrasound - Abstract
Clinical use of high-intensity focused ultrasound (HIFU) under ultrasound or MR guidance as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. Despite the methods' clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial blocking by the rib cage, and high perfusion/flow. Several technical and clinical solutions have been developed by various groups during the past 15 years to compensate for these problems. A review of current unmet clinical needs is given here, as well as a consensus from a panel of experts about technical and clinical requirements for upcoming pilot and pivotal studies in order to accelerate the development and adoption of focused ultrasound for the treatment of primary and secondary liver cancer.
- Published
- 2013
29. Robust real-time MR-geometric distortion correction for interventional procedure on mobile targets
- Author
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Chrit T. W. Moonen, Mario Ries, B. Denis de Senneville, Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Imaging Division, and University Medical Center [Utrecht]
- Subjects
Artifact (error) ,Motion analysis ,Pixel ,medicine.diagnostic_test ,Computer science ,business.industry ,Magnetic resonance imaging ,030218 nuclear medicine & medical imaging ,Magnetic field ,03 medical and health sciences ,0302 clinical medicine ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,Position (vector) ,Distortion ,Medical imaging ,medicine ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Computer vision ,Artificial intelligence ,business ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,030217 neurology & neurosurgery ,ComputingMilieux_MISCELLANEOUS - Abstract
Rapid dynamic MR-imaging can provide both functional and positional informations in real-time, which can be used to retroactively control an interventional procedure. Although rapid echo-planar imaging (EPI) is frequently used in this role, EPI often suffers from geometric distortions. These signal localization errors are caused by spatial magnetic field inhomogeneities induced by magnetic suceptibility variations within the human body and instrumental limitations of the acquisition system. This type of artifact can be addressed by mapping and converting the spatial magnetic field inhomogeneities a priori into a pixel shift and to subsequently correct the EPI-images. Furthermore, for real time guidance of interventions in organs subject to periodical physiological motion, the correction needs to account for time variant changes of the magnetic field during the motion cycle. The correction described in this paper consists of two steps: A parameterized model of the motion induced magnetic field perturbation is computed in a preparative step; subsequently, during the intervention, this model is used to reconstruct the magnetic field perturbation corresponding to the actual organ position in real-time, which in turns allows computation of distortion corrected MR-images.
- Published
- 2012
30. Socially activated neurons in the anterior cingulate cortex are essential for social behavior in mice.
- Author
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Kitagawa K, Takemoto T, Seiriki K, Kasai A, Hashimoto H, and Nakazawa T
- Subjects
- Animals, Mice, Male, Anxiety physiopathology, Behavior, Animal physiology, Gyrus Cinguli physiology, Social Behavior, Neurons physiology, Neurons metabolism, Mice, Inbred C57BL
- Abstract
Social behavior, defined as any mode of communication between conspecifics is regulated by a widespread network comprising multiple brain structures. The anterior cingulate cortex (ACC) serves as a hub region interconnected with several brain regions involved in social behavior. Because the ACC coordinates various behaviors, it is important to focus on a subpopulation of neurons that are potentially involved in social behavior to clarify the precise role of the ACC in social behavior. In this study, we aimed to analyze the roles of a social stimulus-responsive subpopulation of neurons in the ACC in social behavior in mice. We demonstrated that a subpopulation of neurons in the ACC was activated by social stimuli and that silencing the social stimulus-responsive subpopulation of neurons in the ACC significantly impaired social interaction without affecting locomotor activity or anxiety-like behavior. Our current findings highlight the importance of the social stimulus-responsive subpopulation of neurons in the ACC for social behavior and the association between ACC dysfunction and impaired social behavior, which sheds light on therapeutic interventions for psychiatric conditions., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
31. Mouse Cardiovascular Imaging.
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Phoon CKL, Aristizábal O, Farhoud M, Turnbull DH, and Wadghiri YZ
- Subjects
- Animals, Mice, Echocardiography methods, Cardiovascular System diagnostic imaging, Magnetic Resonance Imaging methods
- Abstract
The mouse is the mammalian model of choice for investigating cardiovascular biology, given our ability to manipulate it by genetic, pharmacologic, mechanical, and environmental means. Imaging is an important approach to phenotyping both function and structure of cardiac and vascular components. This review details commonly used imaging approaches, with a focus on echocardiography and magnetic resonance imaging, with brief overviews of other imaging modalities. In this update, we also emphasize the importance of rigor and reproducibility in imaging approaches, experimental design, and documentation. Finally, we briefly outline emerging imaging approaches but caution that reliability and validity data may be lacking. © 2024 Wiley Periodicals LLC., (© 2024 Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
32. Vascular Pathologic Conditions in and around the Spinal Cord.
- Author
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McCarty J, Chung C, Samant R, Sitton C, Bonfante E, Chen PR, Raz E, Shapiro M, Riascos R, and Gavito-Higuera J
- Subjects
- Humans, Diagnosis, Differential, Magnetic Resonance Imaging methods, Spinal Cord Neoplasms diagnostic imaging, Spinal Cord Diseases diagnostic imaging, Vascular Diseases diagnostic imaging, Spinal Cord diagnostic imaging, Spinal Cord blood supply
- Abstract
Diagnosing and differentiating spinal vascular pathologic conditions is challenging. Small structures, lengthy imaging examinations, and overlapping imaging features increase the difficulty. Yet, subtle findings and helpful protocols can narrow the differential diagnosis. The authors aim to help radiologists make accurate and timely diagnoses of spinal vascular pathologic conditions in and around the spinal cord by highlighting spinal vascular anatomy, imaging findings, and three broad categories of abnormalities: infarcts, anomalies, and tumors.
© RSNA, 2024.- Published
- 2024
- Full Text
- View/download PDF
33. Do Not Miss Architectural Distortion.
- Author
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Retson T, Kocher P, Anaam D, Fazeli S, Eghtedari M, and Ojeda-Fournier H
- Published
- 2024
- Full Text
- View/download PDF
34. Hepatic Sinusoidal Disorders.
- Author
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Venkatesh SK, Harper KC, Borhani AA, Furlan A, Thompson SM, Chen EZM, Idilman IS, Miller FH, Hoodeshenas S, Navin PJ, Gu CN, Welle CL, and Torbenson MS
- Subjects
- Humans, Liver Neoplasms diagnostic imaging, Diagnosis, Differential, Hepatic Veno-Occlusive Disease diagnostic imaging
- Abstract
Hepatic sinusoids are highly specialized microcirculatory conduits within the hepatic lobules that facilitate liver functions. The sinusoids can be affected by various disorders, including sinusoidal dilatation, sinusoidal obstruction syndrome (SOS), sinusoidal cellular infiltration, perisinusoidal infiltration, and endothelial neoplasms, such as hemangioendothelioma and angiosarcoma. While these disorders, particularly SOS and neoplasms, can be life threatening, their clinical manifestation is often nonspecific. Patients may present with right upper quadrant pain, jaundice, hepatomegaly, ascites, splenomegaly, and unexplained weight gain, although the exact manifestation depends on the cause, severity, and duration of the disease. Ultimately, invasive tests may be necessary to establish the diagnosis. A comprehensive understanding of imaging manifestations of various sinusoidal disorders contributes to early diagnosis and can help radiologists detect subclinical disease. Additionally, specific imaging features may assist in identifying the cause of the disorder, leading to a more focused and quicker workup. For example, a mosaic pattern of enhancement of the liver parenchyma is suggestive of sinusoidal dilatation; peripheral and patchy reticular hypointensity of the liver parenchyma on hepatobiliary MR images is characteristic of SOS; and associated diffuse multiple hyperintensities on diffusion-weighted images may be specific for malignant sinusoidal cellular infiltration. The authors provide an overview of the pathogenesis, clinical features, and imaging appearances of various hepatic sinusoidal disorders, with a special emphasis on SOS.
© RSNA, 2024 Supplemental material is available for this article.- Published
- 2024
- Full Text
- View/download PDF
35. RadioGraphics Update: The Ninth Edition TNM Staging System for Thymic Epithelial Tumors.
- Author
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Klug M, Kirshenboim Z, Truong MT, Sorin V, Gilat EK, Strange CD, and Marom EM
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- Humans, Thymus Neoplasms diagnostic imaging, Thymus Neoplasms pathology, Neoplasm Staging, Neoplasms, Glandular and Epithelial diagnostic imaging, Neoplasms, Glandular and Epithelial pathology
- Abstract
Editor's Note. - RadioGraphics Update articles supplement or update information found in full-length articles previously published in RadioGraphics . These updates, written by at least one author of the previous article, provide a brief synopsis that emphasizes important new information such as technological advances, revised imaging protocols, new clinical guidelines involving imaging, or updated classification schemes.
- Published
- 2024
- Full Text
- View/download PDF
36. High-angular-sensitivity X-ray phase-contrast microtomography of soft tissue through a two-directional beam-tracking synchrotron set-up.
- Author
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Navarrete-León C, Patrick PS, Doherty A, Allan H, Cipiccia S, Marathe S, Wanelik K, Esposito M, Hagen CK, Olivo A, and Endrizzi M
- Subjects
- Animals, Mice, Liver diagnostic imaging, Swine, Synchrotrons, X-Ray Microtomography methods, Imaging, Three-Dimensional methods
- Abstract
Two-directional beam-tracking (2DBT) is a method for phase-contrast imaging and tomography that uses an intensity modulator to structure the X-ray beam into an array of independent circular beamlets that are resolved by a high-resolution detector. It features isotropic spatial resolution, provides two-dimensional phase sensitivity, and enables the three-dimensional reconstructions of the refractive index decrement, δ, and the attenuation coefficient, μ. In this work, the angular sensitivity and the spatial resolution of 2DBT images in a synchrotron-based implementation is reported. In its best configuration, angular sensitivities of ∼20 nrad and spatial resolution of at least 6.25 µm in phase-contrast images were obtained. Exemplar application to the three-dimensional imaging of soft tissue samples, including a mouse liver and a decellularized porcine dermis, is also demonstrated., (open access.)
- Published
- 2024
- Full Text
- View/download PDF
37. From theory to practice: Implementing next-generation sequencing and public health genomics in healthcare systems.
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Horgan D, Pesapane F, Van der Buckle M, de Maria R, Dube F, Singh J, Ługowska I, Bayle A, Hofman P, Malapelle U, Hills T, Capoluongo ED, and Subbiah V
- Subjects
- Humans, Genomics methods, Public Health methods, Delivery of Health Care, High-Throughput Nucleotide Sequencing methods
- Abstract
If Europe's health systems make a conscious decision to increase their utilization of technology and techniques that can enhance prevention and expedite early-stage diagnosis, they can effectively address the growing challenges of disease. By embracing these advancements, these health systems can significantly improve their response to emerging health issues.However, at present the effective integration and exploitation of these opportunities remains hesitant and suboptimal, and health and health services underperform accordingly, with patients suffering from the continuing variations in diagnosis and access to innovation. This paper presents a comprehensive study that examines the current state of various influential disciplines and factors in European countries. It specifically focuses on the adoption of Next Generation Screening technologies and the development stage of Public Health Genomics. The assessment of these areas is presented in the context of a rapidly changing policy environment, which provides an opportunity for a fundamental reconsideration of how and where new tools can be integrated into healthcare systems and routine practices. Top of Form., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Denis HORGAN reports financial support and article publishing charges were provided by European Commission Directorate-General for Research and Innovation. Denis HORGAN reports a relationship with European Commission Directorate-General for Research and Innovation that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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38. ASO Visual Abstract: Para-aortic Lymph Node Dissection for Colorectal Cancer-Predicting Pathologic Lymph Node Positivity and Optimizing Outcomes.
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Bhutiani N, Ochiai K, Awiwi MO, Rodriguez-Bigas MA, Uppal A, Peacock O, Messick C, White MG, Skibber JM, Bednarski BK, You YN, Chang GJ, Kaur H, and Konishi T
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- Humans, Prognosis, Lymphatic Metastasis, Colorectal Neoplasms pathology, Colorectal Neoplasms surgery, Lymph Node Excision methods, Lymph Nodes pathology, Lymph Nodes surgery
- Published
- 2024
- Full Text
- View/download PDF
39. Para-aortic Lymph Node Dissection for Colorectal Cancer: Predicting Pathologic Lymph Node Positivity and Optimizing Outcomes.
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Bhutiani N, Ochiai K, Awiwi MO, Rodriguez-Bigas MA, Uppal A, Peacock O, Messick C, White MG, Skibber JM, Bednarski BK, You YN, Chang GJ, Kaur H, and Konishi T
- Subjects
- Humans, Male, Female, Aged, Middle Aged, Survival Rate, Retrospective Studies, Follow-Up Studies, Prognosis, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local surgery, Colorectal Neoplasms pathology, Colorectal Neoplasms surgery, Colorectal Neoplasms mortality, Lymph Node Excision, Lymph Nodes pathology, Lymph Nodes surgery, Lymphatic Metastasis
- Abstract
Introduction: In colorectal cancer, the presence of para-aortic lymph nodes (PALN) indicates extraregional disease. Appropriately selecting patients for whom PALN dissection will provide oncologic benefit remains challenging. This study identified factors to predict survival among patients undergoing PALN dissection for colorectal cancer., Methods: An institutional database was queried for patients who underwent curative-intent resection of clinically positive PALN for colorectal cancer between 2007 and 2020. Preoperative radiologic images were reviewed, and patients who did and did not have positive PALN on final pathology were compared. Survival analysis was performed to evaluate the impact of pathologically positive PALN on recurrence-free (RFS) and overall survival (OS)., Results: Of 74 patients who underwent PALN dissection, 51 had PALN metastasis at the time of primary tumor diagnosis, whereas 23 had metachronous PALN disease. Preoperative chemotherapy ± radiotherapy was given in 60 cases (81.1%), and 28 (37.8%) had pathologically positive PALN. Independent factors associated with positive PALN pathology included metachronous PALN disease and pretreatment and posttreatment radiographically abnormal PALN. On multivariable analysis, pathologically positive PALN was significantly associated with decreased RFS (hazard ratio 3.90) and OS (HR 4.49). Among patients with pathologically positive PALN, well/moderately differentiated histology was associated with better OS, and metachronous disease trended toward an association with better OS., Conclusions: Pathologically positive PALN are associated with poorer RFS and OS after PALN dissection for colorectal cancer. Clinicopathologic factors may predict pathologic PALN positivity. Curative-intent surgery may provide benefit, especially in patients with well-to-moderately differentiated primary tumors and possibly metachronous PALN disease., (© 2024. Society of Surgical Oncology.)
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- 2024
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40. Intensive Blood Pressure Control After Endovascular Thrombectomy for Acute Ischemic Stroke: a Systematic Review and Meta-Analysis.
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Abuelazm M, Khildj Y, Ibrahim AA, Mahmoud A, Amin AM, Gowaily I, Khan U, Abdelazeem B, and Brašić JR
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- Humans, Blood Pressure, Randomized Controlled Trials as Topic, Thrombectomy methods, Ischemic Stroke surgery, Endovascular Procedures methods
- Abstract
Background and Purpose: Optimal clinical outcome with successful recanalization from endovascular thrombectomy (EVT) requires optimal blood pressure (BP) management. We aimed to evaluate the efficacy and safety of the intensive BP target (< 140 mm Hg) versus the standard BP target (< 180 mm Hg) after EVT for acute ischemic stroke., Methods: We conducted a systematic review and meta-analysis synthesizing evidence from randomized controlled trials (RCTs) obtained from PubMed, Embase Cochrane, Scopus, and WOS until September 7th, 2023. We used the fixed-effect model to report dichotomous outcomes using risk ratio (RR) and continuous outcomes using mean difference (MD), with a 95% confidence interval (CI)., Prospero Id: CRD42023463206., Results: We included four RCTs with 1559 patients. There was no difference between intensive BP and standard BP targets regarding the National Institutes of Health Stroke Scale (NIHSS) change after 24 h [MD: 0.44 with 95% CI (0.0, 0.87), P = 0.05]. However, the intensive BP target was significantly associated with a decreased risk of excellent neurological recovery (mRS ≤ 1) [RR: 0.87 with 95% CI (0.76, 0.99), P = 0.03], functional independence (mRS ≤ 2) [RR: 0.81 with 95% CI (0.73, 0.90), P = 0.0001] and independent ambulation (mRS ≤ 3) [RR: 0.85 with 95% CI (0.79, 0.92), P < 0.0001]., Conclusions: An intensive BP target after EVT is associated with worse neurological recovery and significantly decreased rates of functional independence and independent ambulation compared to the standard BP target. Therefore, the intensive BP target should be avoided after EVT for acute ischemic stroke., (© 2024. The Author(s).)
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- 2024
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41. Imaging in pelvic exenteration-a multidisciplinary practice guide from the ESGAR-SAR-ESUR-PelvEx collaborative group.
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Nougaret S, Lambregts DMJ, Beets GL, Beets-Tan RGH, Blomqvist L, Burling D, Denost Q, Gambacorta MA, Gui B, Klopp A, Lakhman Y, Maturen KE, Manfredi R, Petkovska I, Russo L, Shinagare AB, Stephenson JA, Tolan D, Venkatesan AM, Quyn AJ, and Forstner R
- Abstract
Pelvic exenteration (PE) is a radical surgical approach designed for the curative treatment of advanced pelvic malignancies, requiring en-bloc resection of multiple pelvic organs. While the procedure is radical, it has shown promise in enhancing long-term survival and is now comparable in surgical mortality to elective resections for primary pelvic cancers. Imaging plays a crucial role in preoperative planning, with MRI, CT, and PET/CT being pivotal in assessing the extent of cancer and formulating a surgical roadmap. This paper presents clinical practice guidelines for imaging in the context of PE, developed jointly by ESGAR, SAR, ESUR, and the PelvEx Collaborative. These guidelines aim to standardize imaging protocols and reporting to improve the preoperative assessment and facilitate decision-making in the multidisciplinary treatment of pelvic cancers. Our recommendations underscore the importance of a multidisciplinary approach and the need for clear and precise imaging reports to optimize patient care. CLINICAL RELEVANCE STATEMENT: Our recommendations underscore the importance of a multidisciplinary approach and the need for clear and precise imaging reports to optimize patient care. KEY POINTS: MRI is mandatory for local staging in pelvic exenteration. Structured reporting (using the template provided in this guide) is recommended. Multidisciplinary review of imaging is critical for surgical planning., (© 2024. The Author(s), under exclusive licence to European Society of Radiology.)
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- 2024
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42. CARJ Editor's Award 2024.
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Ertl-Wagner BB, Green CR, and Patlas MN
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Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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43. Cranial Ultrasound Findings in Infants With Congenital Cytomegalovirus Infection in a Universal Newborn Screening Study in Minnesota.
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Kruc RM, Osterholm EA, Holm T, Nestrasil I, Lanzieri TM, and Schleiss MR
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- Humans, Infant, Newborn, Minnesota, Female, Male, Ultrasonography, Echoencephalography, Neuroimaging, Cytomegalovirus Infections diagnostic imaging, Cytomegalovirus Infections congenital, Neonatal Screening methods, Magnetic Resonance Imaging
- Abstract
Background: Congenital cytomegalovirus (cCMV) is the most common infectious cause of neurodevelopmental deficits in US children. To inform patient management, it is important to define whether central nervous system (CNS) manifestations are present at birth. This study characterized neuroimaging findings in infants with cCMV identified by a universal screening study in Minnesota during February 2016-December 2022., Methods: Newborns with cCMV infection (confirmed by urine CMV polymerase chain reaction [PCR] testing, obtained following a positive screening saliva and/or dried blood spot result) underwent a diagnostic evaluation that included a cranial ultrasound (cUS) exam, laboratory studies, ophthalmological, and audiological evaluation. Neuroimaging findings and cCMV disease classification were interpreted based on international consensus guidelines., Results: Among 87 newborns with confirmed cCMV, 76 underwent cUS. Of these, 53/76 (70%) had normal examinations, while 23/76 (30%) exhibited cUS findings: for 5 infants, these were clearly cCMV disease-defining, while for 18 infants, there were findings of uncertain significance. Magnetic resonance imaging (MRI) results (n = 10 infants) aligned with cUS cCMV disease-defining findings in 2 infants, while cCMV-specific abnormalities were noted by MRI in 2 of 6 infants with nondiagnostic/incidental cUS findings. Of 9 infants who had both cUS and MRI examination, the average time interval between studies was 220 days (range, 2-1061). Excluding infants with cCMV CNS disease-defining cUS abnormalities, incidental findings were observed more commonly in infants with clinical/laboratory features described in cCMV disease classification guidelines (9/13) than in newborns with completely asymptomatic infections (9/58; P < .0001)., Conclusions: Among infants with cCMV identified in a universal screening study, the majority had a normal cUS. CNS disease-defining abnormalities were present in 7%, while 24% had findings of uncertain significance. We propose that many cUS findings are incidental, and not diagnostic of symptomatic cCMV infection. Although these findings may not be sufficient to define the presence of symptomatic cCMV disease involving the CNS, in our study they were more commonly observed in infants with other clinical and/or laboratory findings associated with symptomatic cCMV infection., (© The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
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- 2024
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44. A systematic review and meta-analysis of correlation of automated breast density measurement.
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Kusumaningtyas N, Supit NISH, Murtala B, Muis M, Chandra M, Sanjaya E, and Octavius GS
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Introduction: Breast cancer is the most common cancer in women and a leading cause of mortality. This systematic review and meta-analysis aims to evaluate the correlation between breast density measurements obtained from various software and visual assessments by radiologists using full-field digital mammography (FFDM)., Methods: Following the PRISMA 2020 guidelines, five databases (Pubmed, Google Scholar, Science Direct, Cochrane Library, and MEDLINE) were searched for studies correlating volumetric breast density with breast cancer risk. The Newcastle-Ottawa Scale and the Joanna Briggs Institute Checklist were used to assess the quality of the included studies. Meta-analysis of correlation was applied to aggregate correlation coefficients using a random-effects model using MedCalc Statistical Software version 19.2.6., Results: The review included 22 studies with a total of 58,491 women. The pooled correlation coefficient for volumetric breast density amongst Volpara™ and Quantra™ was found to be 0.755 (95% CI 0.496-0.890, p < 0.001), indicating a high positive correlation, albeit with a significant heterogeneity (I
2 = 99.89%, p < 0.0001). Subgroup analyses based on study origin, quality, and methodology were performed but did not reveal the heterogeneity cause. Egger's and Begg's tests showed no significant publication bias., Conclusion: Volumetric breast density is strongly correlated with breast cancer risk, underscoring the importance of accurate breast density assessment in screening programs. Automated volumetric measurement tools like Volpara™ and Quantra™ provide reliable assessments, potentially improving breast cancer risk prediction and management., Implications for Practice: Implementing fully automated breast density assessment tools could enhance consistency in clinical practice, minimizing observer variability and improving screening accuracy. These tools should be further validated against standardized criteria to ensure reliability in diverse clinical settings., (Copyright © 2024 The College of Radiographers. Published by Elsevier Ltd. All rights reserved.)- Published
- 2024
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45. Optimizing biopsy training experience for trainees and faculty: Utilizing 5S methodology with a focus on safety.
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Kocher P, Kalyan I, and Ojeda-Fournier H
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This manuscript explores the application of the 5S methodology in optimizing workplace safety and efficiency within the context of biopsy training equipment. Drawing from a Quality Improvement Report presented at the 2023 RSNA annual meeting, our manuscript focuses on implementing 5S principles with a dedicated emphasis on safety (the 6th S). We demonstrate how the systematic application of 5S principles can revolutionize the functionality of biopsy training equipment, mitigate safety risks, and enhance overall workplace productivity. This manuscript offers valuable insights and practical strategies for improving healthcare training environments, with broader implications for quality improvement initiatives in the healthcare sector., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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46. The Efficacy of Medical Interventions for Free-Floating Thrombus in Cerebrovascular Events: A Systematic Review.
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Jayyusi F, AlBarakat MM, Al-Rousan HH, Alawajneh MM, Alkasabrah AR, Abujaber M, Aldabbas ME, Abuelsamen M, Alshgerat Y, Sayuri Y, Alhertani N, BaniAmer M, Shari I, and Brašić JR
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Although free-floating thrombus (FFT) poses a significant risk of stroke or transient ischemic attack (TIA), optimal management strategies are uncertain. To determine the state-of-the-art of medical interventions for FFT, we conducted a systematic review of the efficacy of various medical interventions and factors influencing FFT resolution and recurrence. A comprehensive search of Embase, PubMed, and ScienceDirect identified 61 studies encompassing 179 patients with FFT-related stroke or TIA treated with anticoagulants, antiplatelets, or their combinations. Primary outcomes assessed were stroke recurrence and thrombus resolution. Statistical analyses (Fisher's exact test, chi-square test, Mann-Whitney test, and Kruskal-Wallis test) utilized significance set at p < 0.05. Over a median follow-up of 7 months, thrombus resolution occurred in 65% of patients, while 11.2% experienced recurrence, primarily as TIAs. Cardioembolism was significantly less common in resolved cases ( p = 0.025). Combination therapy (antiplatelets, anticoagulants, and statins) significantly enhanced clot resolution (OR 11.4; 95% CI 1.436-91.91; p = 0.021) compared to monotherapies. Ulcerated plaque was a significant predictor of recurrence (OR 8.2; 95% CI 1.02-66.07; p = 0.048). These findings underscore the superiority of combination therapy in FFT management and highlight the need for targeted interventions in patients with ulcerated plaques to mitigate recurrence risk.
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- 2024
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47. Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial.
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Ludmir EB, Sherry AD, Fellman BM, Liu S, Bathala T, Haymaker C, Medina-Rosales MN, Reuben A, Holliday EB, Smith GL, Noticewala SS, Nicholas S, Price TR, Martin-Paulpeter RM, Perles LA, Lee SS, Lee MS, Smaglo BG, Huey RW, Willis J, Zhao D, Cohen L, Taniguchi CM, Koay EJ, Katz MHG, Wolff RA, Das P, Pant S, Koong AC, and Tang C
- Abstract
Purpose: The EXTEND trial tested the hypothesis that adding comprehensive metastasis-directed therapy (MDT) to chemotherapy would improve progression-free survival (PFS) over chemotherapy alone among patients with oligometastatic pancreatic ductal adenocarcinoma (PDAC)., Methods: EXTEND (ClinicalTrials.gov identifier: NCT03599765) is a multicenter, phase II basket trial randomly assigning patients with ≤five metastases 1:1 to MDT plus systemic therapy versus systemic therapy. Disease progression was defined by radiologic criteria (RECIST v1.1), clinical progression, or death. The primary end point was PFS in the per-protocol population, evaluated after all patients achieved at least 6 months of follow-up. Exploratory end points included systemic immune response measures., Results: Between March 19, 2019, and February 13, 2023, 41 patients were randomly assigned and 40 were eligible for the primary analysis of PFS (19 patients in the MDT arm; 21 patients in the control arm). At a median follow-up time of 17 months, the median PFS time was 10.3 months (95% CI, 4.6 to 14.0) in the MDT arm versus 2.5 months (95% CI, 1.7 to 5.1) in the control arm. PFS was significantly improved by the addition of MDT to systemic therapy ( P = .030 for stratified log-rank test) with a hazard ratio of 0.43 (95% CI, 0.20 to 0.94). No grade ≥3 or greater adverse events related to MDT were observed. Systemic immune activation events were associated with MDT and correlated with improved PFS., Conclusion: This study supports the addition of MDT to systemic therapy for patients with oligometastatic PDAC. Induction of systemic immunity is a possible mechanism of benefit. These results warrant confirmatory trials to refine treatment strategy and provide external validation.
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- 2024
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48. Long-Term Clinical, Radiological, and Mortality Outcomes Following Pneumonitis in Nonsmall Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Analysis.
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Soto-Lanza F, Glick L, Chan C, Zhong L, Wilson N, Faiz S, Gandhi S, Naing A, Heymach JV, Shannon VR, Franco-Vega M, Liao Z, Lin SH, Palaskas NL, Wu J, Shroff GS, Altan M, and Sheshadri A
- Abstract
Aims: Despite known short-term mortality risk of immune checkpoint inhibitor (ICI) pneumonitis, its impact on 1-year mortality, long-term pulmonary function, symptom persistence, and radiological resolution remains unclear., Methods: We retrospectively analyzed 71 nonsmall cell lung cancer (NSCLC) patients treated with anti-PD(L)1 monoclonal antibodies between 2018-2021, who developed pneumonitis. Clinical and demographic covariates were collected from electronic medical record. Cox regression assessed associations with mortality, while logistic regression evaluated associations with persistent symptoms, hypoxemia, and radiological resolution., Results: Steroid-refractory pneumonitis (hazard ratio [HR] = 15.1, 95% confidence interval [95% CI]:3.9-57.8, P < .0001) was associated with higher 1-year mortality compared to steroid-responsive cases. However, steroid-resistant (odds ratio [OR] = 1.4, 95% CI: 0.4-5.1, P = .58) and steroid-dependent (OR = 0.4, 95% CI: 0.1-1.2, P = .08) pneumonitis were not. Nonadenocarcinoma histology (OR = 6.7, 95% CI: 1.6-46.6, P = .01), grade 3+ pneumonitis (OR = 4.6, 95% CI: 1.3-22.7, P = .03), and partial radiological resolution (OR = 6.3, 95% CI: 1.8-23.8, P = .004) were linked to increased pulmonary symptoms after pneumonitis resolution. Grade 3+ pneumonitis (OR = 8.1, 95% CI: 2.3-31.5, P = .001) and partial radiological resolution (OR = 5.45, 95% CI: 1.29-37.7, P = .03) associated with residual hypoxemia. Nonadenocarcinoma histology (OR = 3.6, 95% CI: 1.01-17.6, P = .06) and pretreatment ILAs (OR = 4.8, 95% CI: 1.14-33.09, P = .05) were associated with partial radiological resolution., Conclusions: Steroid refractory pneumonitis increases 1-year mortality in NSCLC patients. Pretreatment ILAs may signal predisposition to fibrosis-related outcomes, seen as partial resolution, which in turn is associated with postresolution symptoms and residual hypoxemia. These findings offer insights for identifying patients at risk of adverse outcomes post-pneumonitis resolution., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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49. Toxicity After Prostate Radiation Therapy: Addressing the Transurethral Resection of the Prostate (TURP) Challenge.
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Ratnakumaran R and Zilli T
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- 2024
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50. Preoperative Magnetic Resonance Guided Single-Dose Partial Breast Irradiation: 5-Year Results of the Prospective Single-Arm ABLATIVE Trial.
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Civil YA, Vasmel JE, Charaghvandi RK, Houweling AC, Vreuls CPH, van Diest PJ, Witkamp AJ, Doeksen A, van Dalen T, Felderhof J, van Dam I, Slotman BJ, Kirby AM, Verkooijen HM, van der Velde S, van der Leij F, and van den Bongard HJGD
- Abstract
Purpose: Preoperative partial breast irradiation (PBI) can increase accuracy of target volume definition and decrease irradiated volumes compared with postoperative PBI. In the ABLATIVE trial (NCT02316561), 15 of 36 patients achieved pathologic complete response 6 to 8 months after preoperative PBI and breast-conserving surgery (BCS). We now present the 5-year results., Methods and Materials: The ABLATIVE trial is a Dutch prospective cohort study conducted in 4 hospitals. Women aged ≥50 years with unifocal, nonlobular breast cancer, estrogen receptor-positive, HER2-negative, and a tumor negative sentinel node were treated between 2015 and 2018 with preoperative single-dose PBI followed by BCS after 6 or 8 months. The primary endpoint was pathologic complete response. Secondary endpoints were annually evaluated oncological outcomes, toxicity, cosmetic outcome (assessed by patients and physicians), and quality of life., Results: Thirty-six patients were treated with BCS 6 (n = 15) and 8 (n = 21) months following PBI. Median tumor size was 13 mm (IQR 9-16 mm). After a median follow-up of 5.5 years (IQR, 5.1-6.0), 2 (6%) patients had ipsilateral breast events and 2 (6%) distant metastases. The 5-year overall survival was 94% (95% CI, 87-100). The 5-year cumulative incidence of clinician-reported grade 1/2 breast fibrosis and breast discomfort/pain were 94%/6% and 75%/6%, respectively. The proportion of patients (very) satisfied with the cosmetic results was 89% at baseline and 78% at 5 years. Cosmetic results evaluated using the BCCT.core software were excellent or good in all patients. The 4-year median global quality of life score was 83 (IQR, 67-92), similar to baseline (83; IQR, 75-83; P = .42)., Conclusions: Preoperative single-dose PBI and BCS may be an oncologically safe treatment with mild late toxicity and no decline in cosmetic results and quality of life during 5 years of follow-up. This means that preoperative instead of standard postoperative irradiation has the potential to challenge the current clinical practice., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2024
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