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The current research aims to investigate the impact of the Connectivist Learning Model on the writing skills of ESL learners in Pakistan. Framework based on Connectivism learning theory strives to enable "social connection" and "mental node development" when writing while offering group idea pooling, debate, transliteration, and editing options. Moreover, it examines how authors create their writings while interacting with their peers. Therefore, to obtain the desired data, a Quasi-experimental approach was used to measure the impact of the model. Ninety undergraduate ESL learners were selected and divided into two groups of 45 each. The groups were randomly selected as control and experimental groups, respectively. Both groups were pre-tested. Only the experimental group received the intervention, while the control group was taught writing skills using the traditional method. After three months, the post-test was administered to both groups, and the scores were compared to see the impact. The results of the tests showed that the experimental group's learners exhibited significant improvement in their writing skills. The implications of this research extend across various dimensions of education, ranging from policy and curriculum design to teacher training and technology infrastructure. By taking these implications into account, educators, policymakers, and researchers can contribute to advancing educational practices that are responsive to the needs of students in an increasingly interconnected and digital world. [ABSTRACT FROM AUTHOR]

Hypertension is persistent elevation in blood pressure for 3-4 weeks. Estimated global prevalence of hypertension suggested that by the Year 2025 (29%) of adult worldwide are suffering from hypertension (1.56 billion). Hypertension complications are hemorrhage, atherosclerosis, renal artery stenosis, angina pectoris end organ damage, cardiomyopathy, myocardial infarction and retinopathy. Along with other drug class Calcium channel blocker are also used for the treatment of hypertension. In this study the possible action of the n-hexane leaves fraction of the Androsace foliosa on isolated rabbit aorta was examined. Antihypertensive activity was examined in the existence of standard agonist like phenylephrine and antagonist like Verapamil. Phenylephrine (PE 1µM) high K+ was used to steady the tissue materials. Additionally to observe the calcium channel blocking effect the tissues were treated with n-hexane segment of A. foliosa leaves. Aortic tissues were treated 4-5intervals with Ca+2- free preparation earlier to control calcium reaction curve (CRCs). Verapamil is utilized as standard calcium channel inhibitory mediator and is used as an antagonist. The Af. n-hexane leaves fraction completely inhibited the precontractions induced by Phenylephrine (1µM) and K+ (80 mM) precontractions, with EC50 standards of 1.0mM (0.3-1.0mg/mL) and 4.90mM (1-3mg/mL), respectively. Androsace foliosa n-hexane leaves fraction was tested for calcium channel inhibitory effect on isolated rabbit aorta. A. foliosa nhexane leaves segment at the dosage of 1mg/mL block the calcium channel approximately (35±5%). Consequence indicates that A. foliosa n-hexane leaves segment block calcium channel in the similar manner as compared to the standard calcium channel blocker drug (verapamil). [ABSTRACT FROM AUTHOR]