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Background Patients with lower-grade glioma (LGG) are often of working age. For LGG patients post-surgical work resumption is at risk from treatment including resective surgery. However, little is known on determinants of returning to work. In this study we examined determinants of post-surgical work resumption after nine months using patient- and tumor-related characteristics, such as tumor and resection cavity locations. Material and Methods This retrospective multicenter cohort study included adults with supratentorial WHO grade II and III gliomas who underwent a first-time surgery in Paris, Munich or Amsterdam between 2011 and 2016. Patient-related characteristics included age, sex, patient condition, received treatments, classification of work type and skill level. Presurgical tumors and postsurgical resection cavities were manually segmented on MRI and registered to standard brain space. These segmentations were mapped to Schaefer, XTRACT and Harvard-Oxford atlas parcellations of cortical, white matter and grey nuclei structures. Predictors of postsurgical return to work were examined in multivariable logistic regression and Bayesian hurdle regression models. Results The cohort consisted of 219 patients. Before surgery 192 (88%) patients were able to work, and after surgery 119 (62%) resumed work. Independent predictors of returning to work were male sex (OR = 3.21, CI = 1.44 - 7.46, p = 0.005) and lower age (per 1 year older, OR = 0.96, CI = 0.92 - 0.99, p = 0.029). No associations were found between work resumption and locations of the tumor or resection cavity. Conclusion Many patients are able to work before and many return to work after first-time LGG surgery. Inability to resume work is exclusively associated with patient-related characteristics and not with tumor or resection locations. This novel information may inform patient counseling.

Objective: Anterior cervical discectomy and fusion (ACDF) and cervical vertebral body replacement of (VBR) are associated with a relatively low rate of complications. Yet, C5 nerve root palsy (C5P) is a severe one, ranging from 3 to 15% of patients referring to current literature. Its pathogenesis [for full text, please go to the a.m. URL]

Objective: Direct cortical stimulation (DCS) and navigated transcranial magnetic stimulation (nrTMS) combined with diffusion tensor image (DTI) have been applied in daily neurosurgical practices to identify the language-related cerebral structures. However, previous investigations on their consistency [for full text, please go to the a.m. URL]

Objective: Neuronavigation for pedicle screw placement in dorsal instrumentation is routinely performed in multiple centers. Neuronavigation for lateral instrumentation is also an upcoming approach. With this in mind, we started to perform navigated dorsal and lateral instrumentation of the lumbar spine [for full text, please go to the a.m. URL]

Objective: Awake surgery is the gold standard to preserve language function in patients with language eloquent brain tumors. However, some patients are not eligible for awake surgery. A thorough assessment of preoperative language deficits could provide critical information about patients' intraoperative [for full text, please go to the a.m. URL]

Objective: Navigated transcranial magnetic stimulation (nTMS) has been applied in routine clinical practice to localize motor-eloquent regions. Yet, the cortical representation of peripheral nerves nor their alterations by gliomas were investigated so far. The current study therefore analyzes the impact [for full text, please go to the a.m. URL]

Objective: A considerable number of gliomas require resection via direct electrical stimulation (DES) during awake craniotomy. Likewise, the feasibility of resecting language-eloquent gliomas purely based on navigated repetitive transcranial magnetic stimulation (nrTMS) has been shown. This study analyzes[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Intraoperative motor evoked potentials (MEP) have increased patient's safety and extent of resection in patients with motor eloquent brain tumors. Subcortical stimulation has emerged as an additional tool that may improve functional and oncological outcome even more. However, it is mainly[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Quality of life years (QALY) are nowadays commonly used to estimate the efficiency and benefits of the chosen treatment. Despite its universal presence in health-economical papers, the utilities used to assess QALYs often lack evidence and are mostly extrapolated by other neurological disorders[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Cortical plasticity has been shown in glioma patients by direct cortical stimulation (DCS) during awake craniotomy. However, this invasive option for repeated mapping is only available in case of tumor recurrence and after decision for a second surgery. Navigated repetitive transcranial magnetic[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Preserving functionality is of significant importance during neurosurgical resection of brain tumors. Particularly within the temporo-parieto-occipital junction a large white matter pathway network of higher brain functions including arithmetic processing (AP) is located. Recently, the feasibility[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Subarachnoid bleeding is a highly traumatic event for patients. While the recovery from cognitive and physical impairment is well monitored, evaluation of the psychological outcome is still lacking. Methods: An observational study of patients following treatment for aneurysmal SAH between[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Navigated transcranial magnetic stimulation (nTMS) is increasingly applied to map human language functions. However, despite its promising role especially for preoperative assessment of patients with intracranial lesions, studies on protocol comparisons are mostly lacking. Thus, the present[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie