93 results on '"Ilkova H"'
Search Results
2. Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries
- Author
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Vaxillaire, M. Bonnefond, A. Liatis, S. Ben Salem Hachmi, L. Jotic, A. Boissel, M. Gaget, S. Durand, E. Vaillant, E. Derhourhi, M. Canouil, M. Larcher, N. Allegaert, F. Medlej, R. Chadli, A. Belhadj, A. Chaieb, M. Raposo, J.-F. Ilkova, H. Loizou, D. Lalic, N. Vassallo, J. Marre, M. Froguel, P.
- Abstract
Background: Diagnosis of monogenic diabetes has important clinical implications for treatment and health expenditure. However, its prevalence remains to be specified in many countries, particularly from South Europe, North Africa and Middle-East, where non-autoimmune diabetes in young adults is increasing dramatically. Aims: To identify cases of monogenic diabetes in young adults from Mediterranean countries and assess the specificities between countries. Methods: We conducted a transnational multicenter study based on exome sequencing in 204 unrelated patients with diabetes (age-at-diagnosis: 26.1 ± 9.1 years). Rare coding variants in 35 targeted genes were evaluated for pathogenicity. Data were analyzed using one-way ANOVA, chi-squared test and factor analysis of mixed data. Results: Forty pathogenic or likely pathogenic variants, 14 of which novel, were identified in 36 patients yielding a genetic diagnosis rate of 17.6%. The majority of cases were due to GCK, HNF1A, ABCC8 and HNF4A variants. We observed highly variable diagnosis rates according to countries, with association to genetic ancestry. Lower body mass index and HbA1c at study inclusion, and less frequent insulin treatment were hallmarks of pathogenic variant carriers. Treatment changes following genetic diagnosis have been made in several patients. Conclusions: Our data from patients in several Mediterranean countries highlight a broad clinical and genetic spectrum of diabetes, showing the relevance of wide genetic testing for personalized care of early-onset diabetes. © 2020 Elsevier B.V.
- Published
- 2021
3. Symptoms of depression and diabetes-specific emotional distress are associated with a negative appraisal of insulin therapy in insulin-naïve patients with Type 2 diabetes mellitus. A study from the European Depression in Diabetes [EDID] Research Consortium
- Author
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Makine, C., Karşdağ, Ç., Kadoğlu, P., Ilkova, H., Karşdağ, K., Skovlund, S. E., Snoek, F. J., and Pouwer, F.
- Published
- 2009
4. Increased intestinal permeability as a cause of fluctuating postprandial blood glucose levels in Type 1 diabetic patients
- Author
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Damci, T., Nuhoglu, I., Devranoglu, G., Osar, Z., Demir, M., and Ilkova, H.
- Published
- 2003
5. Liraglutide and Renal Outcomes in Type 2 Diabetes
- Author
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Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB, LEADER Steering Committee and Investigators. Bergenstal R, Daniels G, Moses AC, Nauck M, Nissen S, Pocock S, Steinberg W, Stockner M, Kristensen P, Ravn LS, Zychma M, Flyvbjerg A, Ford I, Kloos RT, Schactman MJ, Sleight P, Swedberg K, Tenner SM, Akalın S, Arechavaleta R, Bain S, Babkowski MC, Benroubi M, Berard L, Comlekci A, Czupryniak L, Eliasson B, Eriksson M, Fonseca V, Franek E, Gross J, Hafidh K, Haluzik M, Hayes F, Huang YY, Jacob S, Kaddaha G, Khalil A, Kilhovd B, Laakso M, Leiter L, Lalic N, Ji L, Luedemann J, Mannucci E, Marre M, Masmiquel L, Mota M, Omar M, O’Shea D, Pan C, Petrie J, Pieber T, Pratley R, Raz I, Rea R, Rutten G, Satman I, Shestakova M, Simpson R, Smith D, Tack C, Tarnow L, Thomas N, Van Gaal L, Travert F, Vidal J, Warren M, Yoon KH, Tuttle RM, Sheerman SI, Hegedüs L, Baerwald H, Bergenstal M, Celik S, Dias C, Eder M, Fitzgibbons S, Irvhage L, Kloluckova J, Kriulianski R, McDuffie R, Moen S, Paster A, Saalfeld RM, Sankar K, Shehaj E, Swierzewska P, Tiktin M, Tovey S, Gibson CM, Chakrabarti AK, Dashe JF, Hinchey J, Leary MC, Pride Y, Wiviott S, Allen S, Mehr AP, Mutter WP, Parikh S, Ray S, Cheifetz A, Leffler D, Sheth S, Alexander E, Gaglia JL, Goessling W, Mitzner LD, Rosenberg C, Snow KJ, Wagner A, Piazza G, Abell S, Davis T, D'Emden M, Ding SA, Gilfillan C, Greenaway T, Gunawan F, Ho J, Jackson R, Kalra B, Lau SL, Lin J, MacIsaac R, Makepeace A, Malabu U, Marjason J, McCallum R, McLean M, Moin N, Petersons C, Price S, Roberts A, Roberts D, Sangla K, Stranks S, Tan Y, Thynne T, Walters J, Ward G, Wen W, Zhang J, Brix J, Feder A, Höbaus C, Höllerl F, Höller V, Kotter T, Kratz E, Krzizek EC, Leb-Stoeger U, Mader J, Mras N, Novak E, Obendorf F, Peric S, Pesau G, Prager R, Ribitsch A, Schnack C, Schernthaner G, Wascher T, Batens AH, Benhalima K, De Block C, Ernest P, Fouckova A, Jandrain B, Lapauw B, Letiexhe M, Mathieu C, Neven S, Peiffer F, Ruige J, Scheen A, Taes Y, Van Boxelaer I, Vandistel G, Van Durme Y, Verhaegen A, Alencar E, Alencar R, Almeida AC, Alves B, Alves E, Alves G, Alves J, Araujo L, Arruda V, Augusto GA, Baggentoss R, Balestrassi L, Barbosa M, Barcelos I, Belem L, de Bem A, Betti RT, Bona R, Bosco A, Branda J, Bronstein M, Bueno T, Bulcão T, Caiado F, Camazzola F, Cambréa MF, Campos S, Canani L, Carra MK, Caruso S, Carvalho N, Casillo A, Castro D, Cavalcanti T, Cavichioli V, Cercato C, Chacra A, Challela W, Charchar HS, Chaves C, Chrisman C, Correia-Deur J, da Costa A Jr, Costa M, Costi B, Coutinho P, Coutinho W, Cunha MR, Daher J Jr, Davini E, Democh D Jr, Eliaschewitz F, Esmanhoto Facin G, Farias F, Felício J, Fernandes V, Filho CS, Filho FF, Filho M, Fontan D, Fontenele AP, Forti A, Franco D, Freire K, Fusaro A, Genestreti P, Gerchman F, Godi A, Gomes KF, Gonçalves P, Gonçalves R, Griz L, Grossman M, Gurgel MH, Vasconcellos Haddad AW, Halpern A, Hissa M, Inuy A, Jaime J, Jonasson T, Jorge JC, Malucelli FJ, Kohara S, Kramer C, Lacerda C, Ladeira S, Lana J, Lastebasse F, Leitão A, Leite S, Lerário AC, Lima D, Lima M, Lippi V, Lunardi M, Machado E, Maia F, Maia J, Maia KP, Mañas N, Marchisotti F, Marinho C, Martins C, Figueiredo de Medeiros F, Melo A, Melo F, Mendonca E, Mendonça P, Filho RM, Miguel M, Miléo K, Miyahara M, Montenegro AP, Moraes A, Moreira A, Ítalo Mota J, Mothe FS, Murro A, Nakatani V, Napoli TF, Neto BG, Neto OQ, Niclewicz E, Ohe LN, Oliveira F, Oliveira M, Panarotto D, Parente E, Parolin S, Pechmann L, Costa da Penha P, Perlamagna L, Perotta B, Pimentel L, Pinto M, Poço C, Ponte C, Prazeres P, Quintao E, Raduan R, Rassi DT, Rassi N, Reck L, Montenegro R Jr, Ribeiro R, Rodovalho S, Silveira Rodrigues G, Rollin G, Rossi S, Sabino C, Sales AP, Salles J, Sampaio CR, Santana L, Sato V, da Silva Santos M, Santos NL, Santos R, Saraiva J, Sartori C, Sena R, Sevilha M, Sgarbi J, Silva D, D'albuquerque Silva L, Silva ME, Siqueira K, Soares S, Sobreira W, Sousa B, Souza AC, Souza B, Tambascia M, Tarantino R, Tenor F, Tomarchio M, Triches C, Tristão LJ, Valenti A, Vasques E, Vencio S, Vianna A, Munhoz Vidotto T, Vieira S, Villar H, Visconti G, Volaco A, Wajchenberg B, Zanatta L, Zimmerman L, Abbott EC, Abu-Bakare A, Advani A, Allison R, Bishara P, Bowering CK, Cheng A, Chouinard S, Clayton D, Conway J, D'Amours M, de Tugwell B, DeYoung P, D'Ignazio G, Dube F, Ekoe JM, Fagan S, Garceau C, Gottesman I, Hanna A, Harris S, Hramiak IM, Hurd C, Imran S, Josse R, Joyce C, Kaiser S, Khan F, Kirouac I, Kovacs C, Labonte I, Langlois WJ, Levac MF, Liutkus J, McDonald C, Milosevic V, Nyomba BL, Paul T, Raby K, Ransom T, Reichert SM, Retnakaran R, Rabasa-Lhoret R, Raff E, Shaikholeslami R, Sigalas J, Yip CE, Weisnagel SJ, Woo V, Bao Y, Cai X, Chen J, Chen K, Chen M, Chen X, Chen Y, Ji Y, Lei J, Li H, Liu P, Mu Y, Ren M, Ren Y, Shi Y, Wang D, Wang F, Wang J, Wang Y, Yan L, Yang G, Yang J, Yu X, Yuan G, Xu M, Zhao X, Zheng J, Zhou L, Anderlová K, Brožová J, Haluzík M, Hanušová V, Kosák M, Křížová J, Mráz M, Owen K, Rušavý Z, Tomešová J, Trachta P, Žourek M, Andersen PH, Boesgaard T, Christensen S, Gram J, Gregersen S, Henriksen JE, Hermansen K, Jakobsen PE, Jensen J, Krogsaa A, Larsen M, Lervang HH, Madsbad S, Mortensen L, Olesen T, Pietraszek A, Ridderstråle M, Safai N, Schioldan AG, Schmidt C, Snorgaard O, Stidsen J, Cederberg H, Haapamäki H, Hukkanen J, Jauhiainen R, Kujari ML, Lahtela J, Laine M, Mäkelä J, Miilunpohja M, Savolainen M, Taurio J, Vänttinen M, Creton C, Cosma NV, Dillinger J, Jacques JL, Guedj AM, Moulla M, Petit C, Ratsianoharana V, Richter D, Rodier M, Roussel R, Hinz A, Politz E, Esser M, Deuse U, Mittag D, Hagenow A, Jacob F, Jordan R, Gantke D, Venschott-Jordan U, Löhr C, Klausmann G, Eschenbrücher K, Karakas M, Jahrsdörfer B, Kunze MR, Wöhrle J, König W, Spielhagen H, Kilimnik A, Lüdemann HP, Lüdemann J, Mölle A, Mölle M, Müller J, Appelt S, Sauter A, Sauter J, Hartmann U, Löw A, Krötz F, Sohn HY, von Schacky C, Klauss V, Braun D, Segner A, Degtyareva E, Kreutzmann K, Paschmionka R, Hauck N, Sihal O, Busch AK, Maus O, Stübler P, Füllgraf-Horst S, Vietzke A, Müller C, Tosch-Sisting R, Lengsfeld B, Thaler J, Schaum T, Steindorf J, Steindorf S, König A, Reitschuster S, Schlott D, Clever HU, Witzel P, Kempe HP, Stemler L, Benis A, Diakoumopoulou E, Kazakos K, Kypraios N, Liatis S, Pagkalos E, Siami E, Tentolouris N, Alur VC, Agrawal M, Ali M, Asirvatham A, Asirvatham E, Bandgar TR, Balaji M, Bardoloi N, Baruah M, Bekur R, Bhansali A, Bhatia S, Bhonsley S, Bhuyan S, Borah B, Bright N, Ambrish C, Chaudhury T, Choudhury S, Chellan G, Das M, Dharmalingam M, Dutta P, Erugu A, Vinutha FP, Gunasekaran P, Das Gupta R, Iqbal A, Jagadish P, Jain S, Jebasingh H, John A, John M, Kalra S, Kasaragod P, Kesavadev J, Kumar H, Kumar P, Lakshmanan V, Lila AR, Mathew T, Miyen H, Mohan T, Motha A, Murthy C, Shivashankara N, Nanaiah A, Ommen T, Pani K, Pandey K, Paramesh S, Paramesh V, Pillai B, Prabhu M, Kalki RC, Ramachandran S, Ramu M, Rao Y, Reddy S, Saikia P, Saravu K, Selvam K, Sethi B, Shankar A, Sharma A, Shah N, Shankar P, Shetty R, Shivane V, Srivalli S, Thaseen 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Lumera G, Magistro A, Maranghi M, Martelli D, Mattina A, Monti LD, Parise M, Pedace E, Perticone F, Piatti P, Pompea Antonia Baldassarre M, Ragghianti B, Repaci A, Ribichini D, Da Ros S, Rossi M, Santilli M, Sesti G, Setola E, Succurro E, Sussolano E, Tarquini G, Verga S, Vitale V, Alanis RR, del Rosario Arechavaleta-Granell M, de Jesús Beltran Jaramillo T, de Jesús Rodríguez Berrones DA, Rodríguez Briones I, Rodríguez Briones R, Acevedo Castañeda ES, Chapa Grimaldo JB, Flores-Moreno CA, Garza Felix S, Nieto Flores J, Morales Franco G, Garza Morán RA, Hernández González SO, González-Gálvez G, González González JG, Hernández Salazar E, García Hernández PA, Campos Hurtado S, López-Velázco ML, Cardona Muñóz EG, Nuñez Márquez R, Campos Moreno OV, Cavazos Oliveros FJ, Haro Ortiz JA, Pelayo-Orozco ES, Sida Perez P, Vazquez Ramírez R, Uribe Rios MA, López Rodríguez JC, Rodríguez Rosales M, Robledo Durón I, Alvarado Ruíz R, González Saldivar G, Reyes Sánchez R, Sánchez-Michel BL, Contreras Sandoval AY, Velasco Gutiérrez A, Perez Verdín AE, Ramos Zavala MG, Abbink-Zandbergen E, Ahdi M, Bugter A, van Dijk M, Eisma G, Erdtsieck R, Gerards M, Gerdes V, Haak H, Harbers V, Hoogenberg K, Huvers F, Janssen W, Kars M, Kooy A, Lafeber M, Landewé-Cleuren S, Lieverse A, Meesters E, Moerman S, van Moorsel D, Nijhuis J, Smit CJ, Thevissen K, Timmerman Thijssen DM, Willemsen A, Birkeland K, Cooper J, Gulseth H, Hjelmesæth J, Jørgensen P, Kilhovd BK, Kulseng B, Nicolaisen B, Skadberg Ø, Wium C, Antkowiak-Piatyszek K, Arciszewska M, Bajkowska-Fiedziukiewicz A, Bogdanski P, Czubek U, Cypryk K, Dabrowski J, Dabrowska M, Dziedzic S, Dziewit T, Faligowska M, Fedor-Plenkowska G, Gajos G, Galicka-Latala D, Galuszka-Bilinska A, Gladysz I, Grycewicz J, Hachula G, Janas I, Jazwinska-Tarnawska E, Jedynasty K, Jozefowska M, Kaminska A, Katra B, Kitowska-Koterla J, Klupa T, Koblik T, Konduracka E, Konieczny J, Konieczny M, Kosinski M, Kulkowski G, Kunecki M, Kurmaniak M, Lesniewski R, Lominska T, Losa B, Majkowska D, Malecki M, Mirocka J, Misztal M, Mruk K, Musialik K, Olejniczak H, Opadczuk P, Peczynska J, Plinta M, Polaszewska-Muszynska M, Przech E, Pupek-Musialik D, Ruzga Z, Scibor Z, Sidorowicz-Bialynicka A, Siegel A, Stankiewicz A, Strzelecka-Sosik A, Swierszcz T, Szulinska M, Szymkowiak K, Trybul I, Witek P, Wozniak I, Zambrzycki J, Zarzycka-Lindner G, Zuradzka-Wajda D, Zurawska-Klis M, Ahn HY, Chin SO, Choi SH, Chon S, Han KA, Jang HC, Jeong KC, Kang SM, Kim JW, Kim HS, Kim SJ, Kim SW, Kim YS, Lee EY, Lim S, Min KW, Nam JY, Oh SJ, Park SY, Rhee SY, Shin JA, Son JI, Song YD, Woo JT, Yang HK, Yoo JS, Yoon JW, Avram R, Braicu MD, Carlan L, Catrinoiu D, Ciomos D, Ciorba A, Ghise G, Girgavu S, Guja C, Mihai D, Nicodim S, Nistor L, Pintilei DR, Pintilei E, Pletea N, Pop A, Rosu M, Savu O, Serban V, Sima A, Sitterli-Natea C, Suciu G, Szabo M, Szilagyi I, Timar B, Vlad A, Vladu IM, Alfaraj A, Dubova V, Dvoryashina I, Gaysina L, Gromova S, Gudkova K, Ivanova S, Ivashkina I, Kalashnikova M, Kazankova T, Khaykina E, Khaykina O, Kiseleva T, Komissarova E, Kononenko I, Koreneva V, Koshcheeva O, Koshel L, Kozachuk D, Kufelkina T, Kunitsyna M, Likhodey N, Lysenko T, Makarova O, Malceva A, Mikhailova S, Ogorodnikova E, Pavlikova I, Pekareva E, Postoeva A, Reshedko D, Reshedko G, Reshedko L, Rogaleva A, Rogova L, Rozanov D, Runov G, Samylina I, Semikina T, Sergeeva-Kondrachenko M, Shatskaya O, Shimokhina O, Smetanina S, Startseva M, Strelkova A, Suplotova L, Suvorova L, Sych Y, Valeeva A, Valeeva F, Venjkova T, Vinokurova V, Voychik E, Yanovskaya E, Yanovskaya M, Yarkova N, Yarygina E, Yuzhakova N, Zakharova T, Zanozina O, Zenovko A, Zhuk S, Zhukova E, Aleksic S, Bulatovic A, Buric B, Cvijovic G, Jelic MA, Jojic B, Jotic A, Kendereski A, Lalic K, Lukic L, Macesic M, Petkovic MM, Micic D, Milicic T, Popovic L, Prostran M, Rajkovic N, Seferovic J, Singh S, Stojanovic R, Stosic L, Vuksanovic M, Zamaklar M, Zivkovic TB, Zoric S, Aboo N, Albertse HW, Badat A, Basson M, Bawa E, Bester F, Blignaut S, Booysen S, Bosch FJ, Burgess L, Cassimjee S, Coetzee K, Du Bois J, Engelbrecht J, Finegan K, Gibson GJ, Hansa S, Hemus A, Immink IP, Jacovides A, Joshi P, Joshi S, Kapp C, KhoeleMachobane S, Uys Knox HJ, Kok J, Komati S, Lai E, Lakha D, Lehloenyane K, Mahomed AG, Meeding R, Moodley R, Moosa N, Nel J, Nell H, Van Niekerk FJ, Pillay N, Pretorius M, Prozesky H, Ramduth S, Roos J, Sarvan M, Seeber M, Siebert M, Somasundram P, Stavrides A, Venter N, Wadvalla S, Alcolea JO, Álvarez de Arcaya Vicente A, Pérez Arroyo MB, Romero Bobillo E, Buño MM, Carreira Arias JN, Cepero García D, Masmiquel Comas L, Coves Figueras MJ, de la Cuesta Mayor C, Feria-Carot MD, Frade Fernández AM, Ferreiro Gómez M, García García C, García Delgado E, Durán García S, Gómez Gómez LA, Soto González A, Hernán García C, Ángeles Tapia Herrero M, Jodar Gimeno E, Quevedo Juanals J, López Jiménez M, Masanes F, Marco Mur ÁL, Navarro López M, Ramis JN, Palmer AG, Calle Pascual A, Romero Pérez LG, Morales Portillo C, Prieto González S, Mezquita Raya P, Reyes García R, Vera TR, Rodríguez Castro C, Rodríguez Rodríguez I, Sacanella Meseguer E, Serrano Olmedo I, Lopez Soto A, Toba Alonso F, Aliaga Verdugo A, Vidal Cortada J, Vigil Medina L, Ackefelt-Frick E, Alfredsson H, Beling E, Benedek P, Crisby M, Dorkhan M, Drescik T, Eeg-Olofsson K, Eliasson K, Fardelin P, Fredholm A, Frid A, Gerok-Andersson K, Hjelmaeus L, Hufnagl A, Jasinska E, Kowalska E, Lafolie P, Lindquist O, Lundvall M, Melander E, Nicander C, Moris L, Tengmark BO, Saphir U, Skagerberg P, Steczkó-Nilsson C, Strandell B, Tomson Y, Chen JY, Chen YC, Chiang CY, Chou CW, Ho CW, Hsiao PJ, Hsieh MC, Hsu RS, Hsu SR, Huang CH, Hung WW, Lee MY, Lee YM, Lin CW, Lin CH, Lin KD, Lin SD, Lin SF, Liou MJ, Lu WT, Shin SJ, Sia HK, Su MH, Su SL, Sun JH, Tien KJ, Tsai DH, Tsai SS, Tu ST, Wang CC, Wang SY, Yang CY, Yen FC, Acikgoz A, Akalin S, Akin S, Akinci B, Akkurt A, Akturk M, Alkis N, Altun I, Altunbas HA, Altuntas Y, Araz M, Aribas S, Arslan E, Arslan G, Arslan M, Ataoglu EH, Ayan F, Aydin K, Aydogan BI, Ayvaz G, Bahadir MA, Balci MK, Basaran MN, Baskal N, Bugra MZ, Calan M, Cavdar U, Cetin F, Cinar N, Colbay M, Dagdelen S, Damci T, Davutoglu V, Demir M, Demir T, Deyneli O, Dincer I, Dogan B, Kanipek Doker KY, Engin I, Eraydin A, Erbas T, Erdogan MF, Ersoy C, Gedik A, Gokay F, Gul OO, Guler S, Gumus T, Gunes E, Gurler MY, Hatipoglu E, Ilkova H, Iyidir OT, Kabakci G, Karadag B, Karatemiz G, Karci AC, Kartal E, Kaya EB, Keskin C, Keskin EF, Kocabas G, Kocak F, Kol AK, Korkmaz H, Kucukler FK, Mesci BA, Oguz A, Orbay E, Oz H, Ozcan ND, Ozdem S, Ozisik S, Ozkan C, Ozsan M, Ozyazar M, Parlar H, Sargin H, Sargin M, Saygili F, Selek A, Simsek Y, Sisman P, Solmaz K, Soydas C, Tatliagac S, Tamer I, Temizkan S, Tulunay C, Tuncel E, Turker F, Unluhizarci K, Unluturk U, Uygur MM, Vatansever B, Yazici D, Yavuz DG, Yener S, Yenigun M, Yilmaz M, Abbas S, Alawadi F, Aziz AA, Bashier A, Rashid F, Abraham P, Adamson K, Atkin S, Aye M, Azam M, Barnett AH, Bellary S, Dhatariya K, Eaton M, English P, Ewing J, Furlong N, Gibson M, Green D, Herring R, Hordern V, Jaap A, Javed Z, Johnson A, Konya J, Kumar S, Lindsay R, Mackie A, McGlynn S, McKenzie J, Millward A, Murthy N, Paisey R, Pearson E, Piya M, Ramell M, Robertson D, Russell-Jones D, Saravanan P, Sathyapalan T, Shakher J, Shiels H, Sivaraman S, Smith J, Srinivas-Shankar U, Stokes J, Tracey I, Vaidya B, Yee M, Yemparala P, Walker J, Wiggins P, Williams J, Wright J, Mackinnon C, Inkster J, Zeeshan J, Bejnariu C, Malipatil N, Giritharan S, Lonnen K, Kyrou I, Aamir S, Ababa M, Abreu M, Adams D, Adams P, Aden J, Aguilar D, Aguillon A, Ahmed A, Ahmed B, Ahmed I, Akhtar A, Akright B, Akright L, Albarracin C, Albert S, Ali S, Aliuddin B, Almasmary A, Al-Maweri A, Alzohaili O, Amador W, Amine M, Amini S, Anderson M, Anderson L, Anderson R, Andrews M, Angel J, Anteer W, Anthony V, Antillon A, Anzures P, Arcon-Rios S, Arkin D, Arodak B, Aronne L, Aronoff S, Arreola G, Arroyo S, Asnani S, Astudillo-Tee G, Ault S, Austin B, Avila V, Avitabile N, Awasty V, Azar M, Aziz A, Bahrami P, Baig M, Bailey K, Bailey T, Baker M, Bala NS, Balbes-Reyes I, Baldwin D, Baldwin E, Balentine T, Ballard T, Baloch K, Banarer S, Baney C, Banka A, Barber L, Barber M, Barker T, Barnes K, Barnum O, Barra J, Bartkowiak A, Baula G, Bautista A, Bayliss R, Beaman M, Beatty K, Becker J, Bedolla L, Begum G, Belejchak P, Bell A, Beltran M, Belucher C, Bensfield E, Benton J, Bergamo K, Bergman B, Berry M, Bettino K, Beyea M, Bhargava A, Bhattacharya A, Bilas A, Bischoff L, Bixler L, Bizjack S, Blank R, Blankfield R, Block L, Bloodworth J, Bloomberg K, Bloomberg R, Blustin J, Boban I, Bolden A, Boncu O, Bookless P, Brassie C, Brautigam D, Bressler P, Brewster R, Brown C, Brown D, Brown F, Bruskewitz M, Bryant D, Buchanan C, Buchanan N, Buck G, Buckley S, Bueno J, Burke D, Burton K, Buske S, Byars W, Bye R, Caldwell R, Calvin K, Camacho R, Campbell E, Cannon D, Cantrell J, Caplan J, Cardenas C, Carlton J, Carpio G, Carrol A, Cartwright L, Casanova G, Castaneda L, Castle M, Castro L, Catangay J, Chaidarun S, Chambers J, Chambliss T, Chandra L, Chang A, Chang S, Chappel J, Chappel C, Chappell T, Charles C, Chavira A, Chaykin L, Check E, Chee L, Cherry A, Chestnut A, Chiarot J, Chiniwala N, Chionh K, Choe J, Christiansen M, Chrzanowski S, Chuang E, Chuck L, Clyatt J, Cohan B, Cohen R, Comi R, Comulada-Rivera A, Conner K, Connor G, Contreras R, Cook K, Cook R, Corder C, Cornejo B Sr, Cornette L, Cortes G, Cortez L, Cox C, Cox G, Craig W, Cramer B, Cromer C, Cromer M, Cuddihy R, Culmer D, Curran H, Curran M, Dadis C, Dagogo-Jack S, Dairywala I, D'Alessio D, Damberg G, Dang A, Daniel K, Davidson M, Dean J, DeBold R, Deitz P, Del M, Delaney D, Delgado E, DeMicco M, DeMuro MA, DeSalle D, Desouza C, Devireddy K, DeVries B, Dezube M, Diab I, Diesburg-Stanwood A, Dilliard J, Dilling J, Diner J, Dishongh K, Dodis R, Doing C, Doll W, Donoho A, Donovan D, Doremus N, Dorfman S, Doshi P, Dostou J, Douglas D, Douglass S, Dowell M, Drazich E, Driver E, Du H, DuBose R III, Duclos M, Dunn K, Dunnam T, Durham N, Dye L, Eagerton D, Ebenibo S, Edeoga C, Edwards G, Ekwensi J, El Asmar I, El Sayad N, Eliopoulos C, Elkosseifi M, Elmer R, Elmore M, Elson D, ElZein L, Emmert L, Erbe L, Estes S, Estrada L, Estrada A, Eveleigh T, Everhart B, Faas F, Faircloth C, Farmer M, Fehr K, Ferguson T, Fernandes J, Ferree K, Ferrington B, Fitzhugh M, Fitzsimmons R, Flanders D, Flores M, Flores E, Flores J, Florida C, Flynn J, Folmar P, Forbes R, Ford W, Fowler M, Fraker A, Francis S, Franco-Cotto E, Fratila C, Fuentes M, Galagan R, Galloway A, Garcia M, Garcia R, Garriott M, Garza J, Gass N, Gates S, Geary M, Geiger K, Geishauser J, Giglio A, Gilbert M, Godwin S, Goetter B, Goley A, Golici L, Gomori E, Gonzales J, Gore A, Gorman T, Gosmanova A, Goswami K, Gotham A, Govoni J, Graddick S, Grant T, Greca A, Green C, Greenbaum K, Greenwald J, Grover D, Grunberger G, Guice M, Guirao D, Gunna V, Guseva N, Ha T, Hagan A, Hager S, Haggag A, Haggar M, Hamilton M, Hamlet P, Hammond J, Hansen A, Harrell W, Harris E, Harris K, Harris M, Harrison L, Hartman I, Hatch A, Hayes D, Hayes M, Heath J, Heineman R, Heinzman A, Hendrick M, Herbst R, Hermayer K, Hibbard J, Hill WD, Hilliard B, Hix M, Hoch B, Hollander P, Holmes Z, Horobetz C, Horowitz R, Hsieh P, Hsieh S, Htun W, Huang J, Huber C, Hudson T, Huizar S, Hull B, Hull J, Hummer K, Hundal R, Hunt G, Hunt V, Hutchinson P, Hwang J, Iannamorelli A, Iannuzzi L, Ingram M, Iram N, Ismail-Beigi F, Jabbour S, Jackson T, Jaen L, Jain V, Jannesari R, Januski V, Japa U, Jarvis K, Jayson L, Jensen R, Jester D, Jocko C, Johnson C, Johnson M, Johnston K, Jones D, Jones J, Jordan T, Juarez M, Kaapuraala A, Kain A, Kaiser V, Kamradt K, Karatoprakli P, Karegar M, Karounos C, Karounos D, Karunaratne H, Katalenich B, Katic K, Katz M, Kaur G, Kawa A, Keib C, Keider G, Kem D, Kennedy R, Kenney B, Kereiakes D, Ketana M, Kettinger L, Khaira A, Khan A, Khan K, Khan M, Khoo T, Khrlobyan N, Kilgore J, Kim G, Kimble S, Kinsley M, Kitchen T, Klick M, Kniffen W, Knight R, Kodzwa D, Koenig T, Komarovskiy K, Kong Y, Koontz D, Krishnasamy S, Krueger E, Kuechenmeister L, Kuehl A, Kuettel K, Kugler D, Kulow T, Kupriyanchik I, Kuruvanka T, Kushner D, Kwon E, Kwon S, Kyle M, LaBryer L, Labuda J, Lafave J, Laguerre J, Laliberte A, Lane J, Langel C, Lann D, Largay J, Latif K, Latus T, Lawrence J, Ledger G, Lee FG, Lee E, Leffert J, Leinung M, Lenhard MJ, Lentino J, Leon J, Leonard M, Letassy N, Leuck K, Levin P, Levinson D, Lewis M, Light T, Lim J, Lindamood R, Lingvay I, Lipps J, Lisa A, Livingston Y, Llamas L, Loesch R, Long T, Looby R, Lopez C, Lorenz T, Lovre D, Lu P, Lucas K, Luevano G, Luidens M, Luna B, Luttrell L, Lyons T, MacAdams M, Mack D, Mack M, Madden M, Madder R, Madireddy S, Mae L, Mahakala A, Maheshwari H, Malbari H, Maldonado N, Mallitz M, Mandviwala M, Mann K, Mardahay M, Marino J, Marney A, Marshall L, Martin A, Martin 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Odugbesan A, Oliver M, Oliver T, Olmeda C, O'Neil C, Oremus R, Ortega T, Ortiz-Santos S, Osborn T, Padmanabhan S, Papacostea O, Park I, Parker A, Parker K, Parker R, Patel C, Patel M, Patel R, Patino M, Patterson S, Paulson K, Paz A, Pemba R, Pepe C, Perez J, Perez T, Perry D, Phillips B, Phillips J, Pickett A, Pinson M, Pitzer R, Poduri M, Poehls J, Poteat T, Powell L, Prasad S, Prevost J, Price E, Priest D, Prieto L, Purewal T, Purighalla R, Purighalla U, Quadrel M, Qureshi A, Radhamma R, Rafla E, Rajab H, Ramalingam R, Ramirez A, Ramirez J, Ramirez K, Ramirez M, Randall M, Rangaraj U, Rao V, Rasmussen P, Rasouli N, Ray A, Reed J, Rems L, Renaud K, Reno M, Resnick M, Reusch J, Reynolds L, Rhoton K, Rhudy J, Ricci C, Rice L, Richardson A, Richardson L, Rickard H, Rickels M, Riff D, Rightenour N, Risser J, Rizvi A, Robertson J, Robinson A, Robinson R, Rockwell M, Rodriguez JP, Rodriguez M, Rojas M, Rojas W, Rooker-Morris L, Root C, Rose M, Rosenberg R, Rosenstock J, Roth M, Ruby R, 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C, Wise J, Witte M, Wittenmyer J, Wood C, Wood R, Woodruff C, Worthington B, Wynn D, Wysham C, Xavier P, Yela S, Yenoby L, Young L, Younus N, Yourell V, Zaid M, Zubair I., Mann, Jfe, Ørsted, Dd, Brown-Frandsen, K, Marso, Sp, Poulter, Nr, Rasmussen, S, Tornøe, K, Zinman, B, Buse, Jb, Bergenstal R, LEADER Steering Committee and Investigators., Daniels, G, Moses, Ac, Nauck, M, Nissen, S, Pocock, S, Steinberg, W, Stockner, M, Kristensen, P, Ravn, L, Zychma, M, Flyvbjerg, A, Ford, I, Kloos, Rt, Schactman, Mj, Sleight, P, Swedberg, K, Tenner, Sm, Akalın, S, Arechavaleta, R, Bain, S, Babkowski, Mc, Benroubi, M, Berard, L, Comlekci, A, Czupryniak, L, Eliasson, B, Eriksson, M, Fonseca, V, Franek, E, Gross, J, Hafidh, K, Haluzik, M, Hayes, F, Huang, Yy, Jacob, S, Kaddaha, G, Khalil, A, Kilhovd, B, Laakso, M, Leiter, L, Lalic, N, Ji, L, Luedemann, J, Mannucci, E, Marre, M, Masmiquel, L, Mota, M, Omar, M, O’Shea, D, Pan, C, Petrie, J, Pieber, T, Pratley, R, Raz, I, Rea, R, Rutten, G, Satman, I, Shestakova, M, Simpson, R, Smith, D, Tack, C, Tarnow, L, Thomas, N, Van Gaal, L, Travert, F, Vidal, J, Warren, M, Yoon, Kh, Tuttle, Rm, Sheerman, Si, Hegedüs, L, Baerwald, H, Bergenstal, M, Celik, S, Dias, C, Eder, M, Fitzgibbons, S, Irvhage, L, Kloluckova, J, Kriulianski, R, Mcduffie, R, Moen, S, Paster, A, Saalfeld, Rm, Sankar, K, Shehaj, E, Swierzewska, P, Tiktin, M, Tovey, S, Gibson, Cm, Chakrabarti, Ak, Dashe, Jf, Hinchey, J, Leary, Mc, Pride, Y, Wiviott, S, Allen, S, Mehr, Ap, Mutter, Wp, Parikh, S, Ray, S, Cheifetz, A, Leffler, D, Sheth, S, Alexander, E, Gaglia, Jl, Goessling, W, Mitzner, Ld, Rosenberg, C, Snow, Kj, Wagner, A, Piazza, G, Abell, S, Davis, T, D'Emden, M, Ding, Sa, Gilfillan, C, Greenaway, T, Gunawan, F, Ho, J, Jackson, R, Kalra, B, Lau, Sl, Lin, J, Macisaac, R, Makepeace, A, Malabu, U, Marjason, J, Mccallum, R, Mclean, M, Moin, N, Petersons, C, Price, S, Roberts, A, Roberts, D, Sangla, K, Stranks, S, Tan, Y, Thynne, T, Walters, J, Ward, G, Wen, W, Zhang, J, Brix, J, Feder, A, Höbaus, C, Höllerl, F, Höller, V, Kotter, T, Kratz, E, Krzizek, Ec, Leb-Stoeger, U, Mader, J, Mras, N, Novak, E, Obendorf, F, Peric, S, Pesau, G, Prager, R, Ribitsch, A, Schnack, C, Schernthaner, G, Wascher, T, Batens, Ah, Benhalima, K, De Block, C, Ernest, P, Fouckova, A, Jandrain, B, Lapauw, B, Letiexhe, M, Mathieu, C, Neven, S, Peiffer, F, Ruige, J, Scheen, A, Taes, Y, Van Boxelaer, I, Vandistel, G, Van Durme, Y, Verhaegen, A, Alencar, E, Alencar, R, Almeida, Ac, B, Alve, Alves, E, Alves, G, Alves, J, Araujo, L, Arruda, V, Augusto, Ga, Baggentoss, R, Balestrassi, L, Barbosa, M, Barcelos, I, Belem, L, de Bem, A, Betti, Rt, Bona, R, Bosco, A, Branda, J, Bronstein, M, Bueno, T, Bulcão, T, Caiado, F, Camazzola, F, Cambréa, Mf, Campos, S, Canani, L, Carra, Mk, Caruso, S, Carvalho, N, Casillo, A, Castro, D, Cavalcanti, T, Cavichioli, V, Cercato, C, Chacra, A, Challela, W, Charchar, H, C, Chave, Chrisman, C, Correia-Deur, J, da Costa, A Jr, Costa, M, Costi, B, Coutinho, P, Coutinho, W, Cunha, Mr, Daher, J Jr, Davini, E, Democh, D Jr, Eliaschewitz, F, Esmanhoto Facin, G, Farias, F, Felício, J, Fernandes, V, Filho, C, Filho, Ff, Filho, M, Fontan, D, Fontenele, Ap, Forti, A, Franco, D, Freire, K, Fusaro, A, Genestreti, P, Gerchman, F, Godi, A, Gomes, Kf, Gonçalves, P, R, Gonçalve, Griz, L, Grossman, M, Gurgel, Mh, Vasconcellos Haddad AW, Halpern, A, Hissa, M, Inuy, A, J, Jaime, Jonasson, T, Jorge, Jc, Malucelli, Fj, Kohara, S, Kramer, C, Lacerda, C, Ladeira, S, Lana, J, Lastebasse, F, Leitão, A, Leite, S, Lerário, Ac, Lima, D, Lima, M, Lippi, V, Lunardi, M, Machado, E, Maia, F, Maia, J, Maia, Kp, Mañas, N, Marchisotti, F, Marinho, C, C, Martin, Figueiredo de Medeiros, F, Melo, A, Melo, F, Mendonca, E, Mendonça, P, Filho, Rm, Miguel, M, Miléo, K, Miyahara, M, Montenegro, Ap, Moraes, A, Moreira, A, Ítalo Mota, J, Mothe, F, Murro, A, Nakatani, V, Napoli, Tf, Neto, Bg, Neto, Oq, Niclewicz, E, Ohe, Ln, Oliveira, F, Oliveira, M, Panarotto, D, Parente, E, Parolin, S, Pechmann, L, Costa da Penha, P, Perlamagna, L, Perotta, B, Pimentel, L, Pinto, M, Poço, C, Ponte, C, Prazeres, P, Quintao, E, Raduan, R, Rassi, Dt, Rassi, N, Reck, L, Montenegro, R Jr, Ribeiro, R, Rodovalho, S, Silveira Rodrigues, G, Rollin, G, Rossi, S, Sabino, C, Sales, Ap, Salles, J, Sampaio, Cr, Santana, L, Sato, V, da Silva Santos, M, Santos, Nl, Santos, R, Saraiva, J, Sartori, C, Sena, R, Sevilha, M, Sgarbi, J, Silva, D, D'albuquerque Silva, L, Silva, Me, Siqueira, K, Soares, S, Sobreira, W, Sousa, B, Souza, Ac, Souza, B, Tambascia, M, Tarantino, R, Tenor, F, Tomarchio, M, Triches, C, Tristão, Lj, Valenti, A, Vasques, E, Vencio, S, Vianna, A, Munhoz Vidotto, T, Vieira, S, Villar, H, Visconti, G, Volaco, A, Wajchenberg, B, Zanatta, L, Zimmerman, L, Abbott, Ec, Abu-Bakare, A, Advani, A, Allison, R, Bishara, P, Bowering, Ck, Cheng, A, Chouinard, S, Clayton, D, Conway, J, D'Amours, M, de Tugwell, B, Deyoung, P, D'Ignazio, G, Dube, F, Ekoe, Jm, Fagan, S, Garceau, C, Gottesman, I, Hanna, A, Harris, S, Hramiak, Im, Hurd, C, Imran, S, Josse, R, Joyce, C, Kaiser, S, Khan, F, I, Kirouac, Kovacs, C, Labonte, I, Langlois, Wj, Levac, Mf, Liutkus, J, Mcdonald, C, Milosevic, V, Nyomba, Bl, Paul, T, Raby, K, Ransom, T, Reichert, Sm, Retnakaran, R, Rabasa-Lhoret, R, Raff, E, Shaikholeslami, R, Sigalas, J, Yip, Ce, Weisnagel, Sj, Woo, V, Bao, Y, Cai, X, Chen, J, Chen, K, Chen, M, Chen, X, Chen, Y, Ji, Y, Lei, J, Li, H, Liu, P, Mu, Y, Ren, M, Ren, Y, Shi, Y, Wang, D, Wang, F, Wang, J, Wang, Y, Yan, L, Yang, G, Yang, J, Yu, X, Yuan, G, Xu, M, Zhao, X, Zheng, J, Zhou, L, Anderlová, K, Brožová, J, Haluzík, M, Hanušová, V, Kosák, M, Křížová, J, Mráz, M, Owen, K, Rušavý, Z, Tomešová, J, Trachta, P, Žourek, M, Andersen, Ph, Boesgaard, T, Christensen, S, Gram, J, Gregersen, S, Henriksen, Je, Hermansen, K, Jakobsen, Pe, Jensen, J, Krogsaa, A, Larsen, M, Lervang, Hh, Madsbad, S, Mortensen, L, Olesen, T, Pietraszek, A, Ridderstråle, M, Safai, N, Schioldan, Ag, Schmidt, C, Snorgaard, O, Stidsen, J, Cederberg, H, Haapamäki, H, Hukkanen, J, Jauhiainen, R, Kujari, Ml, Lahtela, J, Laine, M, Mäkelä, J, Miilunpohja, M, Savolainen, M, Taurio, J, Vänttinen, M, Creton, C, Cosma, Nv, Dillinger, J, Jacques, Jl, Guedj, Am, Moulla, M, Petit, C, Ratsianoharana, V, Richter, D, Rodier, M, Roussel, R, Hinz, A, Politz, E, Esser, M, Deuse, U, Mittag, D, Hagenow, A, Jacob, F, Jordan, R, Gantke, D, Venschott-Jordan, U, Löhr, C, Klausmann, G, Eschenbrücher, K, Karakas, M, Jahrsdörfer, B, Kunze, Mr, Wöhrle, J, König, W, Spielhagen, H, Kilimnik, A, Lüdemann, Hp, Lüdemann, J, Mölle, A, Mölle, M, Müller, J, Appelt, S, Sauter, A, Sauter, J, Hartmann, U, Löw, A, Krötz, F, Sohn, Hy, von Schacky, C, Klauss, V, Braun, D, Segner, A, Degtyareva, E, Kreutzmann, K, Paschmionka, R, Hauck, N, Sihal, O, Busch, Ak, Maus, O, Stübler, P, Füllgraf-Horst, S, Vietzke, A, Müller, C, Tosch-Sisting, R, Lengsfeld, B, Thaler, J, Schaum, T, Steindorf, J, Steindorf, S, König, A, Reitschuster, S, Schlott, D, Clever, Hu, Witzel, P, Kempe, Hp, Stemler, L, Benis, A, Diakoumopoulou, E, Kazakos, K, Kypraios, N, Liatis, S, Pagkalos, E, Siami, E, Tentolouris, N, Alur, Vc, Agrawal, M, Ali, M, Asirvatham, A, Asirvatham, E, Bandgar, Tr, Balaji, M, Bardoloi, N, Baruah, M, Bekur, R, Bhansali, A, Bhatia, S, Bhonsley, S, Bhuyan, S, Borah, B, Bright, N, Ambrish, C, Chaudhury, T, Choudhury, S, Chellan, G, M, Da, Dharmalingam, M, Dutta, P, Erugu, A, Vinutha, Fp, Gunasekaran, P, Das Gupta, R, Iqbal, A, Jagadish, P, Jain, S, Jebasingh, H, John, A, John, M, Kalra, S, Kasaragod, P, Kesavadev, J, Kumar, H, Kumar, P, Lakshmanan, V, Lila, Ar, Mathew, T, Miyen, H, Mohan, T, Motha, A, Murthy, C, Shivashankara, N, Nanaiah, A, Ommen, T, Pani, K, Pandey, K, Paramesh, S, Paramesh, V, Pillai, B, Prabhu, M, Kalki, Rc, Ramachandran, S, Ramu, M, Rao, Y, Reddy, S, Saikia, P, Saravu, K, Selvam, K, Sethi, B, Shankar, A, Sharma, A, Shah, N, Shankar, P, Shetty, R, Shivane, V, Srivalli, S, Thaseen, S, Sarada, S, Shirisha, A, Subramani, M, Balaji, V, Mohan, V, Padmanaban, V, Verma, M, Vidyasagar, S, Walinjkar, V, Walia, R, Davenport, C, Forde, H, Gadintshware, G, Gan, Kj, Khattak, A, O'Connell, J, O'Shea, D, Beilin, V, Cahn, A, Cohen, O, Cukierman-Yaffe, T, Daoud, D, Darawsha, M, Dicker, D, Gavish, A, Hochberg, I, Ilany, J, Inbal, U, Itzhak, B, Karasik, A, Karnieli, E, Khader, N, Khamaisi, M, Lender, D, Lieberman, G, Mahamid, R, Marcoviciu, D, Michael, L, Minuchin, O, Mosenzon, O, Narevichius, F, Percik, R, Potekhin, M, Sabbah, M, Sawaed, S, Schurr, D, Segal, E, Slezak, L, Vollach, I, Zaina, A, Zloczower, M, Zolotov, S, Antenore, A, Arnone, M, Arturi, F, Barbaro, V, Barone, M, Di Biagio, R, Buscemi, C, Buscemi, S, Buzzetti, R, Di Carlo, A, Carlone, A, Caruso, V, Casadidio, I, Cerrelli, F, Ciavarella, A, Cipolloni, L, Colella, A, Colotto, M, Consoli, A, Crippa, Vg, Cuccuru, I, Cufone, S, Desideri, C, Fallarino, M, Febo, F, Filetti, S, Foffi, C, Formoso, G, Frosio, L, Di Fulvio, P, Gambineri, A, Ginestra, F, Grimaldi, M, Lamanna, C, Leto, G, Lucotti, P, Lugarà, M, Lumera, G, Magistro, A, Maranghi, M, Martelli, D, Mattina, A, Monti, Ld, Parise, M, Pedace, E, Perticone, F, Piatti, P, Pompea Antonia Baldassarre, M, Ragghianti, B, Repaci, A, Ribichini, D, Da Ros, S, Rossi, M, Santilli, M, Sesti, G, Setola, E, Succurro, E, Sussolano, E, Tarquini, G, Verga, S, Vitale, V, Alanis, Rr, del Rosario Arechavaleta-Granell, M, de Jesús Beltran Jaramillo, T, de Jesús Rodríguez Berrones DA, Rodríguez Briones, I, Rodríguez Briones, R, Acevedo Castañeda ES, Chapa Grimaldo JB, Flores-Moreno, Ca, Garza Felix, S, Nieto Flores, J, Morales Franco, G, Garza Morán RA, Hernández González SO, González-Gálvez, G, González González JG, Hernández Salazar, E, García Hernández PA, Campos Hurtado, S, López-Velázco, Ml, Cardona Muñóz EG, Nuñez Márquez, R, Campos Moreno OV, Cavazos Oliveros FJ, Haro Ortiz JA, Pelayo-Orozco, E, Sida Perez, P, Vazquez Ramírez, R, Uribe Rios MA, López Rodríguez JC, Rodríguez Rosales, M, Robledo Durón, I, Alvarado Ruíz, R, González Saldivar, G, Reyes Sánchez, R, Sánchez-Michel, Bl, Contreras Sandoval AY, Velasco Gutiérrez, A, Perez Verdín AE, Ramos Zavala MG, Abbink-Zandbergen, E, Ahdi, M, Bugter, A, van Dijk, M, Eisma, G, Erdtsieck, R, Gerards, M, Gerdes, V, Haak, H, Harbers, V, Hoogenberg, K, Huvers, F, Janssen, W, Kars, M, Kooy, A, Lafeber, M, Landewé-Cleuren, S, Lieverse, A, Meesters, E, Moerman, S, van Moorsel, D, Nijhuis, J, Smit, Cj, Thevissen, K, Timmerman Thijssen DM, Willemsen, A, Birkeland, K, Cooper, J, Gulseth, H, Hjelmesæth, J, Jørgensen, P, Kilhovd, Bk, Kulseng, B, Nicolaisen, B, Skadberg, Ø, Wium, C, Antkowiak-Piatyszek, K, Arciszewska, M, Bajkowska-Fiedziukiewicz, A, Bogdanski, P, Czubek, U, Cypryk, K, Dabrowski, J, Dabrowska, M, Dziedzic, S, Dziewit, T, Faligowska, M, Fedor-Plenkowska, G, Gajos, G, Galicka-Latala, D, Galuszka-Bilinska, A, Gladysz, I, Grycewicz, J, Hachula, G, Janas, I, Jazwinska-Tarnawska, E, Jedynasty, K, Jozefowska, M, Kaminska, A, Katra, B, Kitowska-Koterla, J, Klupa, T, Koblik, T, Konduracka, E, Konieczny, J, Konieczny, M, Kosinski, M, Kulkowski, G, Kunecki, M, Kurmaniak, M, Lesniewski, R, Lominska, T, Losa, B, Majkowska, D, Malecki, M, Mirocka, J, Misztal, M, Mruk, K, Musialik, K, Olejniczak, H, Opadczuk, P, Peczynska, J, Plinta, M, Polaszewska-Muszynska, M, Przech, E, Pupek-Musialik, D, Ruzga, Z, Scibor, Z, Sidorowicz-Bialynicka, A, Siegel, A, Stankiewicz, A, Strzelecka-Sosik, A, Swierszcz, T, Szulinska, M, Szymkowiak, K, Trybul, I, Witek, P, Wozniak, I, Zambrzycki, J, Zarzycka-Lindner, G, Zuradzka-Wajda, D, Zurawska-Klis, M, Ahn, Hy, Chin, So, Choi, Sh, Chon, S, Han, Ka, Jang, Hc, Jeong, Kc, Kang, Sm, Kim, Jw, Kim, H, Kim, Sj, Kim, Sw, Kim, Y, Lee, Ey, Lim, S, Min, Kw, Nam, Jy, Oh, Sj, Park, Sy, Rhee, Sy, Shin, Ja, Son, Ji, Song, Yd, Woo, Jt, Yang, Hk, Yoo, J, Yoon, Jw, Avram, R, Braicu, Md, Carlan, L, Catrinoiu, D, Ciomos, D, Ciorba, A, Ghise, G, Girgavu, S, Guja, C, Mihai, D, Nicodim, S, Nistor, L, Pintilei, Dr, Pintilei, E, Pletea, N, Pop, A, Rosu, M, Savu, O, Serban, V, Sima, A, Sitterli-Natea, C, Suciu, G, Szabo, M, Szilagyi, I, Timar, B, Vlad, A, Vladu, Im, Alfaraj, A, Dubova, V, Dvoryashina, I, Gaysina, L, Gromova, S, Gudkova, K, Ivanova, S, Ivashkina, I, Kalashnikova, M, Kazankova, T, Khaykina, E, Khaykina, O, Kiseleva, T, Komissarova, E, Kononenko, I, Koreneva, V, Koshcheeva, O, Koshel, L, Kozachuk, D, Kufelkina, T, Kunitsyna, M, Likhodey, N, Lysenko, T, Makarova, O, Malceva, A, Mikhailova, S, Ogorodnikova, E, Pavlikova, I, Pekareva, E, Postoeva, A, Reshedko, D, Reshedko, G, Reshedko, L, Rogaleva, A, Rogova, L, Rozanov, D, Runov, G, Samylina, I, Semikina, T, Sergeeva-Kondrachenko, M, Shatskaya, O, Shimokhina, O, Smetanina, S, Startseva, M, Strelkova, A, Suplotova, L, Suvorova, L, Sych, Y, Valeeva, A, Valeeva, F, Venjkova, T, Vinokurova, V, Voychik, E, Yanovskaya, E, Yanovskaya, M, Yarkova, N, Yarygina, E, Yuzhakova, N, Zakharova, T, Zanozina, O, Zenovko, A, Zhuk, S, Zhukova, E, Aleksic, S, Bulatovic, A, Buric, B, Cvijovic, G, Jelic, Ma, Jojic, B, Jotic, A, Kendereski, A, Lalic, K, Lukic, L, Macesic, M, Petkovic, Mm, Micic, D, Milicic, T, Popovic, L, Prostran, M, Rajkovic, N, Seferovic, J, Singh, S, Stojanovic, R, Stosic, L, Vuksanovic, M, Zamaklar, M, Zivkovic, Tb, Zoric, S, Aboo, N, Albertse, Hw, Badat, A, Basson, M, Bawa, E, Bester, F, Blignaut, S, Booysen, S, Bosch, Fj, Burgess, L, Cassimjee, S, Coetzee, K, Du Bois, J, Engelbrecht, J, Finegan, K, Gibson, Gj, Hansa, S, Hemus, A, Immink, Ip, Jacovides, A, Joshi, P, Joshi, S, Kapp, C, Khoelemachobane, S, Uys Knox HJ, Kok, J, Komati, S, Lai, E, Lakha, D, Lehloenyane, K, Mahomed, Ag, Meeding, R, Moodley, R, Moosa, N, Nel, J, Nell, H, Van Niekerk FJ, Pillay, N, Pretorius, M, Prozesky, H, Ramduth, S, Roos, J, Sarvan, M, Seeber, M, Siebert, M, Somasundram, P, Stavrides, A, Venter, N, Wadvalla, S, Alcolea, Jo, Álvarez de Arcaya Vicente, A, Pérez Arroyo MB, Romero Bobillo, E, Buño, Mm, Carreira Arias JN, Cepero García, D, Masmiquel Comas, L, Coves Figueras MJ, de la Cuesta Mayor, C, Feria-Carot, Md, Frade Fernández AM, Ferreiro Gómez, M, García García, C, García Delgado, E, Durán García, S, Gómez Gómez LA, Soto González, A, Hernán García, C, Ángeles Tapia Herrero, M, Jodar Gimeno, E, Quevedo Juanals, J, López Jiménez, M, Masanes, F, Marco Mur ÁL, Navarro López, M, Ramis, Jn, Palmer, Ag, Calle Pascual, A, Romero Pérez LG, Morales Portillo, C, Prieto González, S, Mezquita Raya, P, Reyes García, R, Vera, Tr, Rodríguez Castro, C, Rodríguez Rodríguez, I, Sacanella Meseguer, E, Serrano Olmedo, I, Lopez Soto, A, Toba Alonso, F, Aliaga Verdugo, A, Vidal Cortada, J, Vigil Medina, L, Ackefelt-Frick, E, Alfredsson, H, Beling, E, Benedek, P, Crisby, M, Dorkhan, M, Drescik, T, Eeg-Olofsson, K, Eliasson, K, Fardelin, P, Fredholm, A, Frid, A, Gerok-Andersson, K, Hjelmaeus, L, Hufnagl, A, Jasinska, E, Kowalska, E, Lafolie, P, Lindquist, O, Lundvall, M, Melander, E, Nicander, C, Moris, L, Tengmark, Bo, Saphir, U, Skagerberg, P, Steczkó-Nilsson, C, Strandell, B, Tomson, Y, Chen, Jy, Chen, Yc, Chiang, Cy, Chou, Cw, Ho, Cw, Hsiao, Pj, Hsieh, Mc, Hsu, R, Hsu, Sr, Huang, Ch, Hung, Ww, Lee, My, Lee, Ym, Lin, Cw, Lin, Ch, Lin, Kd, Lin, Sd, Lin, Sf, Liou, Mj, Lu, Wt, Shin, Sj, Sia, Hk, Su, Mh, Su, Sl, Sun, Jh, Tien, Kj, Tsai, Dh, Tsai, S, Tu, St, Wang, Cc, Wang, Sy, Yang, Cy, Yen, Fc, Acikgoz, A, Akalin, S, Akin, S, Akinci, B, Akkurt, A, Akturk, M, Alkis, N, Altun, I, Altunbas, Ha, Altuntas, Y, Araz, M, Aribas, S, Arslan, E, Arslan, G, Arslan, M, Ataoglu, Eh, Ayan, F, Aydin, K, Aydogan, Bi, Ayvaz, G, Bahadir, Ma, Balci, Mk, Basaran, Mn, Baskal, N, Bugra, Mz, Calan, M, Cavdar, U, Cetin, F, Cinar, N, Colbay, M, Dagdelen, S, Damci, T, Davutoglu, V, Demir, M, Demir, T, Deyneli, O, Dincer, I, Dogan, B, Kanipek Doker KY, Engin, I, Eraydin, A, Erbas, T, Erdogan, Mf, Ersoy, C, Gedik, A, Gokay, F, Gul, Oo, Guler, S, Gumus, T, Gunes, E, Gurler, My, Hatipoglu, E, Ilkova, H, Iyidir, Ot, Kabakci, G, Karadag, B, Karatemiz, G, Karci, Ac, Kartal, E, Kaya, Eb, Keskin, C, Keskin, Ef, Kocabas, G, Kocak, F, Kol, Ak, Korkmaz, H, Kucukler, Fk, Mesci, Ba, Oguz, A, Orbay, E, Oz, H, Ozcan, Nd, Ozdem, S, Ozisik, S, Ozkan, C, Ozsan, M, Ozyazar, M, Parlar, H, Sargin, H, Sargin, M, Saygili, F, Selek, A, Simsek, Y, Sisman, P, Solmaz, K, Soydas, C, Tatliagac, S, Tamer, I, Temizkan, S, Tulunay, C, Tuncel, E, Turker, F, Unluhizarci, K, Unluturk, U, Uygur, Mm, Vatansever, B, Yazici, D, Yavuz, Dg, Yener, S, Yenigun, M, Yilmaz, M, Abbas, S, Alawadi, F, Aziz, Aa, Bashier, A, Rashid, F, Abraham, P, Adamson, K, Atkin, S, Aye, M, Azam, M, Barnett, Ah, Bellary, S, Dhatariya, K, Eaton, M, English, P, Ewing, J, Furlong, N, Gibson, M, Green, D, Herring, R, Hordern, V, Jaap, A, Javed, Z, Johnson, A, Konya, J, Kumar, S, Lindsay, R, Mackie, A, Mcglynn, S, Mckenzie, J, Millward, A, Murthy, N, Paisey, R, Pearson, E, Piya, M, Ramell, M, Robertson, D, Russell-Jones, D, Saravanan, P, Sathyapalan, T, Shakher, J, Shiels, H, Sivaraman, S, Smith, J, Srinivas-Shankar, U, Stokes, J, Tracey, I, Vaidya, B, Yee, M, Yemparala, P, Walker, J, Wiggins, P, Williams, J, Wright, J, Mackinnon, C, Inkster, J, Zeeshan, J, Bejnariu, C, Malipatil, N, Giritharan, S, Lonnen, K, Kyrou, I, Aamir, S, Ababa, M, Abreu, M, Adams, D, Adams, P, Aden, J, Aguilar, D, Aguillon, A, Ahmed, A, Ahmed, B, Ahmed, I, Akhtar, A, Akright, B, Akright, L, Albarracin, C, Albert, S, Ali, S, Aliuddin, B, Almasmary, A, Al-Maweri, A, Alzohaili, O, Amador, W, Amine, M, Amini, S, Anderson, M, Anderson, L, Anderson, R, Andrews, M, Angel, J, Anteer, W, Anthony, V, Antillon, A, Anzures, P, Arcon-Rios, S, Arkin, D, Arodak, B, Aronne, L, Aronoff, S, Arreola, G, Arroyo, S, Asnani, S, Astudillo-Tee, G, Ault, S, Austin, B, Avila, V, Avitabile, N, Awasty, V, Azar, M, Aziz, A, Bahrami, P, Baig, M, Bailey, K, Bailey, T, Baker, M, Bala, N, Balbes-Reyes, I, Baldwin, D, Baldwin, E, Balentine, T, Ballard, T, Baloch, K, Banarer, S, Baney, C, Banka, A, Barber, L, Barber, M, Barker, T, Barnes, K, Barnum, O, Barra, J, Bartkowiak, A, Baula, G, Bautista, A, Bayliss, R, Beaman, M, Beatty, K, Becker, J, Bedolla, L, Begum, G, Belejchak, P, Bell, A, Beltran, M, Belucher, C, Bensfield, E, Benton, J, Bergamo, K, Bergman, B, Berry, M, Bettino, K, Beyea, M, Bhargava, A, Bhattacharya, A, Bilas, A, Bischoff, L, Bixler, L, Bizjack, S, Blank, R, Blankfield, R, Block, L, Bloodworth, J, Bloomberg, K, Bloomberg, R, Blustin, J, Boban, I, Bolden, A, Boncu, O, Bookless, P, Brassie, C, Brautigam, D, Bressler, P, Brewster, R, Brown, C, Brown, D, Brown, F, Bruskewitz, M, Bryant, D, Buchanan, C, Buchanan, N, Buck, G, Buckley, S, Bueno, J, Burke, D, Burton, K, Buske, S, Byars, W, Bye, R, Caldwell, R, Calvin, K, Camacho, R, Campbell, E, Cannon, D, Cantrell, J, Caplan, J, Cardenas, C, Carlton, J, Carpio, G, Carrol, A, Cartwright, L, Casanova, G, Castaneda, L, Castle, M, Castro, L, Catangay, J, Chaidarun, S, Chambers, J, Chambliss, T, Chandra, L, Chang, A, Chang, S, Chappel, J, Chappel, C, Chappell, T, Charles, C, Chavira, A, Chaykin, L, Check, E, Chee, L, Cherry, A, Chestnut, A, Chiarot, J, Chiniwala, N, Chionh, K, Choe, J, Christiansen, M, Chrzanowski, S, Chuang, E, Chuck, L, Clyatt, J, Cohan, B, Cohen, R, Comi, R, Comulada-Rivera, A, Conner, K, Connor, G, Contreras, R, Cook, K, Cook, R, Corder, C, Cornejo, B Sr, Cornette, L, Cortes, G, Cortez, L, Cox, C, Cox, G, Craig, W, Cramer, B, Cromer, C, Cromer, M, Cuddihy, R, Culmer, D, Curran, H, Curran, M, Dadis, C, Dagogo-Jack, S, Dairywala, I, D'Alessio, D, Damberg, G, Dang, A, Daniel, K, Davidson, M, Dean, J, Debold, R, Deitz, P, M, Del, Delaney, D, Delgado, E, Demicco, M, Demuro, Ma, Desalle, D, Desouza, C, Devireddy, K, Devries, B, Dezube, M, Diab, I, Diesburg-Stanwood, A, Dilliard, J, Dilling, J, Diner, J, Dishongh, K, Dodis, R, Doing, C, Doll, W, Donoho, A, Donovan, D, Doremus, N, Dorfman, S, Doshi, P, Dostou, J, Douglas, D, Douglass, S, Dowell, M, Drazich, E, Driver, E, Du, H, Dubose, R III, Duclos, M, Dunn, K, Dunnam, T, Durham, N, Dye, L, Eagerton, D, Ebenibo, S, Edeoga, C, Edwards, G, Ekwensi, J, El Asmar, I, El Sayad, N, Eliopoulos, C, Elkosseifi, M, Elmer, R, Elmore, M, Elson, D, Elzein, L, Emmert, L, Erbe, L, Estes, S, Estrada, L, A, Estrada, Eveleigh, T, Everhart, B, Faas, F, Faircloth, C, Farmer, M, Fehr, K, Ferguson, T, Fernandes, J, Ferree, K, Ferrington, B, Fitzhugh, M, Fitzsimmons, R, Flanders, D, M, Flore, E, Flore, Flores, J, Florida, C, Flynn, J, Folmar, P, Forbes, R, Ford, W, Fowler, M, Fraker, A, Francis, S, Franco-Cotto, E, Fratila, C, Fuentes, M, Galagan, R, Galloway, A, Garcia, M, Garcia, R, Garriott, M, J, Garza, Gass, N, Gates, S, Geary, M, Geiger, K, Geishauser, J, Giglio, A, Gilbert, M, Godwin, S, Goetter, B, Goley, A, Golici, L, Gomori, E, Gonzales, J, Gore, A, Gorman, T, Gosmanova, A, Goswami, K, Gotham, A, Govoni, J, Graddick, S, Grant, T, Greca, A, Green, C, Greenbaum, K, Greenwald, J, Grover, D, Grunberger, G, Guice, M, Guirao, D, Gunna, V, Guseva, N, Ha, T, Hagan, A, Hager, S, Haggag, A, Haggar, M, Hamilton, M, Hamlet, P, Hammond, J, Hansen, A, Harrell, W, Harris, E, Harris, K, Harris, M, Harrison, L, Hartman, I, Hatch, A, Hayes, D, Hayes, M, Heath, J, Heineman, R, Heinzman, A, Hendrick, M, Herbst, R, Hermayer, K, Hibbard, J, Hill, Wd, Hilliard, B, Hix, M, Hoch, B, Hollander, P, Holmes, Z, Horobetz, C, Horowitz, R, Hsieh, P, Hsieh, S, Htun, W, Huang, J, Huber, C, Hudson, T, Huizar, S, Hull, B, Hull, J, Hummer, K, Hundal, R, Hunt, G, Hunt, V, Hutchinson, P, Hwang, J, Iannamorelli, A, Iannuzzi, L, Ingram, M, Iram, N, Ismail-Beigi, F, Jabbour, S, Jackson, T, Jaen, L, Jain, V, Jannesari, R, Januski, V, Japa, U, Jarvis, K, Jayson, L, Jensen, R, Jester, D, Jocko, C, Johnson, C, Johnson, M, Johnston, K, Jones, D, Jones, J, Jordan, T, Juarez, M, Kaapuraala, A, Kain, A, Kaiser, V, Kamradt, K, Karatoprakli, P, Karegar, M, Karounos, C, Karounos, D, Karunaratne, H, Katalenich, B, Katic, K, Katz, M, Kaur, G, Kawa, A, Keib, C, Keider, G, Kem, D, Kennedy, R, Kenney, B, Kereiakes, D, Ketana, M, Kettinger, L, Khaira, A, Khan, A, Khan, K, Khan, M, Khoo, T, Khrlobyan, N, Kilgore, J, Kim, G, Kimble, S, Kinsley, M, Kitchen, T, Klick, M, Kniffen, W, Knight, R, Kodzwa, D, Koenig, T, Komarovskiy, K, Kong, Y, Koontz, D, Krishnasamy, S, Krueger, E, Kuechenmeister, L, Kuehl, A, Kuettel, K, Kugler, D, Kulow, T, Kupriyanchik, I, Kuruvanka, T, Kushner, D, Kwon, E, Kwon, S, Kyle, M, Labryer, L, Labuda, J, Lafave, J, Laguerre, J, Laliberte, A, Lane, J, Langel, C, Lann, D, Largay, J, Latif, K, Latus, T, Lawrence, J, Ledger, G, Lee, Fg, Lee, E, Leffert, J, Leinung, M, Lenhard, Mj, Lentino, J, Leon, J, Leonard, M, Letassy, N, Leuck, K, Levin, P, Levinson, D, Lewis, M, Light, T, Lim, J, Lindamood, R, Lingvay, I, Lipps, J, Lisa, A, Livingston, Y, Llamas, L, Loesch, R, Long, T, Looby, R, Lopez, C, Lorenz, T, Lovre, D, Lu, P, Lucas, K, Luevano, G, Luidens, M, Luna, B, Luttrell, L, Lyons, T, Macadams, M, Mack, D, Mack, M, Madden, M, Madder, R, Madireddy, S, Mae, L, Mahakala, A, Maheshwari, H, Malbari, H, Maldonado, N, Mallitz, M, Mandviwala, M, Mann, K, Mardahay, M, Marino, J, Marney, A, Marshall, L, Martin, A, Martin, E, Martinez, G, Martinez-Miss, S, Marx, P, Massara, L, Mastoor, M, Matfin, G, Maturu, A, Maurides, P, May, M, Mayfield, R, Maynard, B, Mazza, A, Mccann, K, Mccoy, J, Mccoy, T, Mccullen, Mk, Mcdaniel, C, Mcdaniel, Am, Mcdermott, M, Mcdonald, A, Mcmasters, B, Mcmurray, C, Medlin, T, Meinel, M, Mendez, I, Menefee, J, Meredith, M, Merriweather, M, Mersey, J, Messino, C, Meyer, S, Meyers, L, Michael, D, Midyett, C, Miklius, A, Milford, E, Miller, B, Miller, H, Milligan, M, Minor, A, Miranda-Palma, B, Mirarchi, N, Mittadodla, S, Mittle, J, Moffat, A, Mohaupt, S, Mohiuddin, K, Mokshagundam, S, Monaco, S, Monsaert, R, Montano-Pereira, C, Montgomery, A, Moody, K, Moon, M, Moore, D, Moore, L, Morawski, E, Moreau, C, Morin, D, Moscoa, C, Motzkin, C, Mueller, R, Munoz, C, Munoz, M, Myneni, A, Naderi, B, Nagireddy, P, Naidu, J, Naidu, R, Naik, S, Naimark, R, Nardicchi, M, Ndukwu, I, Neller, C, Netten-Foster, L, Neumiller, J, New, T, Newman, S, Newton, T, Nguyen, B, Nicol, B, Nicol, P, Ninivaggi, L, Niswender, K, Norman, L, Noworatzky, G, Nyenwe, E, O'Brien, H, O'Connell, T, Oden, W, Odugbesan, A, Oliver, M, Oliver, T, Olmeda, C, O'Neil, C, Oremus, R, Ortega, T, Ortiz-Santos, S, Osborn, T, Padmanabhan, S, Papacostea, O, Park, I, Parker, A, Parker, K, Parker, R, Patel, C, Patel, M, Patel, R, Patino, M, Patterson, S, Paulson, K, Paz, A, Pemba, R, Pepe, C, Perez, J, Perez, T, Perry, D, Phillips, B, Phillips, J, Pickett, A, Pinson, M, Pitzer, R, Poduri, M, Poehls, J, Poteat, T, Powell, L, Prasad, S, Prevost, J, Price, E, Priest, D, Prieto, L, Purewal, T, Purighalla, R, Purighalla, U, Quadrel, M, Qureshi, A, Radhamma, R, Rafla, E, Rajab, H, Ramalingam, R, Ramirez, A, J, Ramirez, Ramirez, K, Ramirez, M, Randall, M, Rangaraj, U, Rao, V, Rasmussen, P, Rasouli, N, Ray, A, Reed, J, Rems, L, Renaud, K, Reno, M, Resnick, M, Reusch, J, Reynolds, L, Rhoton, K, Rhudy, J, Ricci, C, Rice, L, Richardson, A, Richardson, L, Rickard, H, Rickels, M, Riff, D, Rightenour, N, Risser, J, Rizvi, A, Robertson, J, Robinson, A, Robinson, R, Rockwell, M, Rodriguez, Jp, Rodriguez, M, Rojas, M, Rojas, W, Rooker-Morris, L, Root, C, Rose, M, Rosenberg, R, Rosenstock, J, Roth, M, Ruby, R, Sachson, R, Sack, P, Sadler, Rk, Sahai, S, J, Salazar, Salgam, M, Samal, A, Samson, A, Sanagorski, R, Sanchez, A, Sandberg, J, Sanderson, M, Sandoval, J, Santiago, E, Sapp, T, Saunders, J, Schill, J, Schott, C, Schreiman, R, Schu, D, Schuh, K, Schutta, M, Schwartz, J, Schweppe, L, Scofield, H, Scribner, A, Seal, J, Sealock, J, Seaton, B, Sedlak-Hanslik, T, Seekins, K, Segal, M, Seggelke, S, Semenza, S, Sentman, P, Serra, M, Seshadri, P, Sevilla, E, Shah, S, Shaheen, K, Shanik, M, Shaw, J, Sheets, M, Shellabarger, C, Sher, J, Shippey, J, Shivaswamy, V, Shomali, M, Shore, D, Shroff, P, Siddiqui, T, Siegwald, A, Silver, R, Simmons, D, Simons, R, Sinan, A, Singh, M, Sirinvaravong, S, Skero, J, Slover-Zipf, J, Small, S, Smith, B, Smith, K, Smith, M, Sohl, J, Solarz, Sh, Soler, D, Sood, A, Sora, N, Souchet, A, Soule, J, Sparks, J, Spector, L, Speicher, R, Spillers, L, Spivey, T, Springer, N, Sprouse, H, St John, J, Stacey, A, Stacey, H, Stafford, M, Stagner, E, Staples, K, Steadman, E, Steed, R, Steeves, G, Steinberg, H, Stell, C, Stirman, E, Straub, K, Strock, E, Sue, M, Suris, O, Sutton, T, Tabbah, I, Talsania, M, Tang, R, Tapia, J, Taylor, K, Taylor-Hancher, R, Teator, R, Tekateka, M, Temple, B, Temple, K, Teodori, M, Tharp, P, Thethi, T, Theuma, P, Thomas, S, Thottan, A, Thrasher, J, Thrasher, L, Tiemeyer, M, Tinney, I, Tobin, T, Toma, S, Tovar, M, Townsend, J, Trantow, C, Traylor, H, Trevino, M, Troy, M, Trumper, D, Tryggestad, J, Tucker, C, Turner, J, Turney, R, Tuten, C, Tyzack, J, Ullo, L, Underkofler, C, Unger, J, Urdanetta, R, Valdivia, V, Valenti, S, Vanderheiden, A, Vanderlinde-Wood, M, Varma, C, Vasquez, E, Vazquez, M, Vickery, D, Villafuerte, B, Villegas, C, Vivar, J, Vivekananthan, K, Vo, G, Vukojicic, K, Wachter, A, Wahl, D, Waitmann, J, Walker, D, Walsh, J, Walsh, K, Walton, A, Wang, A, Wardell, K, Watkins, S, Watkinson, J, Watts, M, Watwe, V, Weaver, N, Weber, R, Wedick, C, Weeks, D, Weeks, L, Weindorff, K, Weinstein, R, Weiss, S, Wenger, K, Wentworth, M, Werner, A, West, M, Whelan, S, White, B, White, J, Whitmire, M, Whittington, R, Wical, J, Wigley, C, Wilkins, F, Will, K, Williams, A, Wilson, Le, Wince, M, Wine, S, Winkle, P, Winner, C, Wise, J, Witte, M, Wittenmyer, J, Wood, C, Wood, R, Woodruff, C, Worthington, B, Wynn, D, Wysham, C, Xavier, P, Yela, S, Yenoby, L, Young, L, Younus, N, Yourell, V, Zaid, M, Zubair, I., Mann J.F.E., Orsted D.D., Brown-Frandsen K., Marso S.P., Poulter N.R., Rasmussen S., Tornoe K., Zinman B., Buse J.B., and Buscemi S.
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Male ,Settore MED/09 - Medicina Interna ,Acute Kidney Injury ,Aged ,Albuminuria ,Creatinine ,Diabetes Mellitus, Type 2 ,Diabetic Nephropathies ,Double-Blind Method ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Glucagon-Like Peptide 1 ,Humans ,Hypoglycemic Agents ,Intention to Treat Analysis ,Kidney Failure, Chronic ,Liraglutide ,Middle Aged ,Type 2 diabetes ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,GLOMERULAR-FILTRATION-RATE ,KIDNEY-FUNCTION ,DISEASE ,law.invention ,Kidney Failure ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Medicine ,Settore MED/49 - Scienze Tecniche Dietetiche Applicate ,Chronic ,RISK ,Kidney ,Acute kidney injury ,11 Medical And Health Sciences ,General Medicine ,medicine.anatomical_structure ,TRIAL ,liraglutide, randomized controlled trial, type 2 diabetes, renal outcomes ,Life Sciences & Biomedicine ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Renal function ,030209 endocrinology & metabolism ,CARDIOVASCULAR OUTCOMES ,Follow-Up Studie ,03 medical and health sciences ,Medicine, General & Internal ,General & Internal Medicine ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Intensive care medicine ,Science & Technology ,business.industry ,MORTALITY ,medicine.disease ,INTENSIVE GLUCOSE CONTROL ,INDIVIDUALS ,chemistry ,Diabetic Nephropathie ,LEADER Steering Committee and Investigators ,business - Abstract
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown. METHODS: We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease. The risk of renal outcomes was determined with the use of time-to-event analyses with an intention-to-treat approach. Changes in the estimated glomerular filtration rate and albuminuria were also analyzed. RESULTS: A total of 9340 patients underwent randomization, and the median follow-up of the patients was 3.84 years. The renal outcome occurred in fewer participants in the liraglutide group than in the placebo group (268 of 4668 patients vs. 337 of 4672; hazard ratio, 0.78; 95% confidence interval [CI], 0.67 to 0.92; P=0.003). This result was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer participants in the liraglutide group than in the placebo group (161 vs. 215 patients; hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P=0.004). The rates of renal adverse events were similar in the liraglutide group and the placebo group (15.1 events and 16.5 events per 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years, respectively). CONCLUSIONS: This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .).
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- 2017
6. PDB81 HEALTHCARE RESOURCE USE ASSOCIATED WITH TYPE 2 DIABETES IN AFRICA, EURASIA, THE MIDDLE-EAST AND SOUTH-ASIA: RESULTS FROM THE 7TH WAVE OF THE INTERNATIONAL DIABETES MANAGEMENT PRACTICE STUDY (IDMPS)
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Le Nouveau, P., primary, Pacou, M., additional, Ilkova, H., additional, Aschner, P., additional, Gagliardino, J.J., additional, Lavalle, F., additional, Ramachandran, A., additional, Mbanya, J.C., additional, Shestakova, M., additional, Chantelot, J.M., additional, Chan, J.C.N., additional, and Levorsen, A., additional
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- 2019
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7. Type 2 Diabetes in Turkey – A Cost of Illness Study
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Malhan, S, primary, Schwarzbard, J, additional, Sahin, T, additional, Bilgic, A, additional, Atanasov, PK, additional, Ramachandran, A, additional, Mbanya, JC, additional, Aschner, P, additional, Gagliardino, JJ, additional, Ilkova, H, additional, and Chan, JC, additional
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- 2016
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8. Impact of Diabetes Management on Diabetes Control and Resource Consumption in Type 2 Diabetic Patients
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Chan, JC, primary, Ramachandran, A, additional, Mbanya, JC, additional, Shestakova, MV, additional, Gagliardino, JJ, additional, Ilkova, H, additional, Leguet-Dinville, P, additional, Chantelot, J, additional, Schwarzbard, J, additional, Pacou, M, additional, Taieb, V, additional, and Annemans, L, additional
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- 2016
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9. Impact of Hypoglycaemic Events on Healthcare Resource Use in Type 2 Diabetes Patients
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Chan, JC, primary, Ramachandran, A, additional, Mbanya, JC, additional, Shestakova, MV, additional, Gagliardino, JJ, additional, Ilkova, H, additional, Leguet-Dinville, P, additional, Chantelot, J, additional, Schwarzbard, J, additional, Pacou, M, additional, Taieb, V, additional, and Annemans, L, additional
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- 2016
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10. Cost of Type 2 Diabetes in Urban Indian Population
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Ramachandran, A, primary, Schwarzbard, J, additional, Atanasov, PK, additional, Topiwala, S, additional, Leguet-Dinville, P, additional, Mbanya, JC, additional, Aschner, P, additional, Gagliardino, JJ, additional, Ilkova, H, additional, and Chan, JC, additional
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- 2016
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11. CA-159: Autogestion du diabète de type 1 au Moyen Orient et en Afrique du Nord : résultats de l'étude IDMPS
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Mbanya, J., primary, Chantelot, J., additional, Aschner, P., additional, Gagliardino, J., additional, Ilkova, H., additional, Lavalle, F., additional, Ramachandran, A., additional, Kaddaha, G., additional, Shestakova, M., additional, Huot-Marchand, P., additional, and Chan, J., additional
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- 2016
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12. The role of coping with disease in adherence to treatment regimen and disease control in type 1 and insulin treated type 2 diabetes mellitus
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Janet Turan, Osar, Z., Molzan Turan, J., Damci, T., and Ilkova, H.
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Adult ,Male ,Diabetic Retinopathy ,Outpatient Clinics, Hospital ,Adolescent ,Turkey ,Middle Aged ,Hospitals, University ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Surveys and Questionnaires ,Adaptation, Psychological ,Diet, Diabetic ,Humans ,Insulin ,Patient Compliance ,Female ,Attitude to Health ,Aged - Abstract
Coping is defined as the behavioral and cognitive efforts used in an attempt to deal with stressful events. The objective of this study was to explore the relationship between coping with diabetes and the following outcome variables in type 1 and insulin treated type 2 diabetes mellitus: glycemic control, microangiopathic complications, adherence to self monitoring of blood glucose, adherence to insulin injections, and adherence to diet.Subjects were 196 insulin treated adult diabetes patients visiting an outpatient clinic at a government university hospital in Istanbul, Turkey. Coping with disease was measured with the Turkish version of the Diabetes Coping Measure and adherence to treatment regimen was measured with a questionnaire adapted from the subscales of the Summary of Diabetes Self-Care Activities Questionnaire. Data on patients' HbA(1c) levels and severity of microangiopathic complications were obtained from their medical records.Partial correlations controlling for background variables suggested that coping was a good predictor of outcome for both type 1 and insulin treated type 2 diabetes mellitus. These associations were more pronounced for type 1 patients when compared to type 2 patients. Regressing the outcome variables on the two second-order coping factors (obtained by a factor analysis) also supported the hypothesis that coping is an important construct in explaining the outcome variables. Finally, the effect of coping on HbA(1c) was only partially mediated by adherence.Coping with diabetes-related issues is an important factor in both types of diabetes, with type 1 patients showing slightly stronger associations. Therefore, training and education programs for diabetic adults might benefit from including a component that is aimed at improving coping with issues specific to diabetes.
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- 2002
13. PDB101 - Impact of Diabetes Management on Diabetes Control and Resource Consumption in Type 2 Diabetic Patients
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Chan, JC, Ramachandran, A, Mbanya, JC, Shestakova, MV, Gagliardino, JJ, Ilkova, H, Leguet-Dinville, P, Chantelot, J, Schwarzbard, J, Pacou, M, Taieb, V, and Annemans, L
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- 2016
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14. PDB100 - Impact of Hypoglycaemic Events on Healthcare Resource Use in Type 2 Diabetes Patients
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Chan, JC, Ramachandran, A, Mbanya, JC, Shestakova, MV, Gagliardino, JJ, Ilkova, H, Leguet-Dinville, P, Chantelot, J, Schwarzbard, J, Pacou, M, Taieb, V, and Annemans, L
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- 2016
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15. PDB27 - Type 2 Diabetes in Turkey – A Cost of Illness Study
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Malhan, S, Schwarzbard, J, Sahin, T, Bilgic, A, Atanasov, PK, Ramachandran, A, Mbanya, JC, Aschner, P, Gagliardino, JJ, Ilkova, H, and Chan, JC
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- 2016
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16. PDB29 - Cost of Type 2 Diabetes in Urban Indian Population
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Ramachandran, A, Schwarzbard, J, Atanasov, PK, Topiwala, S, Leguet-Dinville, P, Mbanya, JC, Aschner, P, Gagliardino, JJ, Ilkova, H, and Chan, JC
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- 2016
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17. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.
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UCL - MD/FSIO - Département de physiologie et pharmacologie, Jonas, Jean-Christophe, Sharma, A, Hasenkamp, W, Ilkova, H, Patanè, G, Laybutt, R, Bonner-Weir, S, Weir, G C, UCL - MD/FSIO - Département de physiologie et pharmacologie, Jonas, Jean-Christophe, Sharma, A, Hasenkamp, W, Ilkova, H, Patanè, G, Laybutt, R, Bonner-Weir, S, and Weir, G C
- Abstract
Differentiated pancreatic beta cells are unique in their ability to secrete insulin in response to a rise in plasma glucose. We have proposed that the unique constellation of genes they express may be lost in diabetes due to the deleterious effect of chronic hyperglycemia. To test this hypothesis, Sprague-Dawley rats were submitted to a 85-95% pancreatectomy or sham pancreatectomy. One week later, the animals developed mild to severe chronic hyperglycemia that was stable for the next 3 weeks, without significant alteration of plasma nonesterified fatty acid levels. Expression of many genes important for glucose-induced insulin release decreased progressively with increasing hyperglycemia, in parallel with a reduction of several islet transcription factors involved in beta cell development and differentiation. In contrast, genes barely expressed in sham islets (lactate dehydrogenase A and hexokinase I) were markedly increased, in parallel with an increase in the transcription factor c-Myc, a potent stimulator of cell growth. These abnormalities were accompanied by beta cell hypertrophy. Changes in gene expression were fully developed 2 weeks after pancreatectomy. Correction of blood glucose by phlorizin for the next 2 weeks normalized islet gene expression and beta cell volume without affecting plasma nonesterified fatty acid levels, strongly suggesting that hyperglycemia triggers these abnormalities. In conclusion, chronic hyperglycemia leads to beta cell hypertrophy and loss of beta cell differentiation that is correlated with changes in c-Myc and other key transcription factors. A similar change in beta cell differentiation could contribute to the profound derangement of insulin secretion in human diabetes.
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- 1999
18. Orlistat Augments Postprandial Increases In Glucagon-Like Peptide-1 in Obese Type 2 Diabetic Patients: Response to Horowitz et al.
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Damci, T., primary, Yalin, S., additional, Balci, H., additional, Osar, Z., additional, Korugan, U., additional, Ozyazar, M., additional, and Ilkova, H., additional
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- 2004
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19. Obesity: A heavy burden on type 2 diabetes mellitus
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Ayata, E., primary, Yumuk, V., additional, Gürsu, U., additional, İzmir, Ş., additional, Samanci, T., additional, Oşar, Z., additional, Damci, T., additional, Özyazar, M., additional, Görpe, U., additional, and İlkova, H., additional
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- 2000
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20. Do type 1 and type 2 diabetes coexist?
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Damci, T, primary, Oşar, Z, additional, Yumuk, V, additional, Özyazar, M, additional, and İlkova, H, additional
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- 2000
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21. Diabetes summer camp
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Ipbüker, A., primary, Görpe, U., additional, Ilkova, H., additional, Damci, T., additional, and Bagriaçik, N., additional
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- 1994
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22. Multifaceted determinants for achieving glycemic control: the International Diabetes Management Practice Study (IDMPS).
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Chan JC, Gagliardino JJ, Baik SH, Chantelot JM, Ferreira SR, Hancu N, Ilkova H, Ramachandran A, Aschner P, IDMPS Investigators, Chan, Juliana C N, Gagliardino, Juan Jose, Baik, Sei Hyun, Chantelot, Jean-Marc, Ferreira, Sandra R G, Hancu, Nicolae, Ilkova, Hasan, Ramachandran, Ambady, and Aschner, Pablo
- Abstract
Objective: The International Diabetes Mellitus Practice Study is a 5-year survey documenting changes in diabetes treatment practice in developing regions.Research Design and Methods: Logistic regression analysis was used to identify factors for achieving A1C <7% in 11,799 patients (1,898 type 1 diabetic and 9,901 type 2 diabetic) recruited by 937 physicians from 17 countries in Eastern Europe (n = 3,519), Asia (n = 5,888), Latin America (n = 2,116), and Africa (n = 276).Results: Twenty-two percent of type 1 diabetic and 36% of type 2 diabetic patients never had A1C measurements. In those with values for A1C, blood pressure, and LDL cholesterol, 7.5% of type 1 diabetic (n = 696) and 3.6% of type 2 diabetic (n = 3,896) patients attained all three recommended targets (blood pressure <130/80 mmHg, LDL cholesterol <100 mg/dl, and A1C <7%). Self-monitoring of blood glucose was the only predictor for achieving the A1C goal in type 1 diabetes (odds ratios: Asia 2.24, Latin America 3.55, and Eastern Europe 2.42). In type 2 diabetes, short disease duration (Asia 0.97, Latin America 0.97, and Eastern Europe 0.82) and treatment with few oral glucose-lowering drugs (Asia 0.64, Latin America 0.76, and Eastern Europe 0.62) were predictors. Other region-specific factors included lack of microvascular complications and old age in Latin America and Asia; health insurance coverage and specialist care in Latin America; lack of obesity and self-adjustment of insulin dosages in Asia; and training by a diabetes educator, self-monitoring of blood glucose in patients who self-adjusted insulin, and lack of macrovascular complications in Eastern Europe.Conclusions: In developing countries, factors pertinent to patients, doctors, and health care systems all impact on glycemic control. [ABSTRACT FROM AUTHOR]- Published
- 2009
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23. Does instantaneous blood glucose affect vibration perception threshold measurement using biothesiometer?
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Damci, T., Osar, Z., Beyhan, S., Ilkova, H., Ozyazar, M., Gorpe, U., and Bagriacik, N.
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- 1999
- Full Text
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24. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.
- Author
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Jonas, J C, Sharma, A, Hasenkamp, W, Ilkova, H, Patanè, G, Laybutt, R, Bonner-Weir, S, and Weir, G C
- Abstract
Differentiated pancreatic beta cells are unique in their ability to secrete insulin in response to a rise in plasma glucose. We have proposed that the unique constellation of genes they express may be lost in diabetes due to the deleterious effect of chronic hyperglycemia. To test this hypothesis, Sprague-Dawley rats were submitted to a 85-95% pancreatectomy or sham pancreatectomy. One week later, the animals developed mild to severe chronic hyperglycemia that was stable for the next 3 weeks, without significant alteration of plasma nonesterified fatty acid levels. Expression of many genes important for glucose-induced insulin release decreased progressively with increasing hyperglycemia, in parallel with a reduction of several islet transcription factors involved in beta cell development and differentiation. In contrast, genes barely expressed in sham islets (lactate dehydrogenase A and hexokinase I) were markedly increased, in parallel with an increase in the transcription factor c-Myc, a potent stimulator of cell growth. These abnormalities were accompanied by beta cell hypertrophy. Changes in gene expression were fully developed 2 weeks after pancreatectomy. Correction of blood glucose by phlorizin for the next 2 weeks normalized islet gene expression and beta cell volume without affecting plasma nonesterified fatty acid levels, strongly suggesting that hyperglycemia triggers these abnormalities. In conclusion, chronic hyperglycemia leads to beta cell hypertrophy and loss of beta cell differentiation that is correlated with changes in c-Myc and other key transcription factors. A similar change in beta cell differentiation could contribute to the profound derangement of insulin secretion in human diabetes.
- Published
- 1999
25. Depressive symptoms in people with diabetes: results from the International Diabetes Management Practices Survey
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Aschner, P., Gagliardino, J., Ilkova, H., Lavalle, F., Ramachandran, A., Kaddaha, G., Mbanya, J., Shestakova, M., Bourhis, Y., Chantelot, J., and Chan, J. C. N.
26. Poor glycaemic control in people with type 1 and type 2 diabetes: results from the International Diabetes Management Practices Study (IDMPS)
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Lavalle, F., Aschner, P., Gagliardino, J. J., Ilkova, H., Ramachandran, A., Kaddaha, G., Mbanya, J. C., Shestakova, M., Chantelot, J. -M, and Chan, J. C. N.
27. Frequency of high blood pressure and dyslipidaemia in type 1 and type 2 diabetes: results from the International Diabetes Management Practices Study (IDMPS)
- Author
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Ilkova, H., Kaddaha, G., Gagliardino, J. J., Aschner, P., Lavalle, F., Ramachandran, A., Mbanya, J. C., Shestakova, M., Chantelot, J. -M, and Chan, J. C. N.
28. Changes in glycaemic control and rates of diabetes-related complications in type 2 diabetes: 10 years of the International Diabetes Management Practices Study (IDMPS)
- Author
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Aschner, P., Gagliardino, J. J., Ilkova, H., Lavalle, F., Ramachandran, A., Kaddaha, G., Mbanya, J. C., Shestakova, M., Chantelot, J. M., and Chan, J. C. N.
29. The DIabetic REtinopathy Candesartan Trials (DIRECT) Programme: Baseline characteristics
- Author
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Sjølie, A. K., Bilous, R., Chaturvedi, N., Fuller, J., Fox, Y., George, M., Klein, R., Orchard, T., Parving, H. -H, Massimo Porta, Svensson, A., Warnold, I., Price, G., Aldington, S., Deveney, A., Holloway, J., Janiak, R., Kenny, D., Krisin, E., Lipinski, H., Otterbeck, N., Strannelind, P., Tillin, T., Wilhelmsen, L., Bird, A., Wedel, H., Agardh, C. -D, Bonnici, F., Charbonnel, B., Cooper, M., Dedov, I., Gardiner, R., Gomis, R., Ilkova, H., Katsilambros, N., Kerenyi, Z., Martin, S., Massin, P., Pirags, V., Raz, I., Schernthaner, G., Shestakova, M., Strojek, K., and Puu, M.
30. Management and achievement of glycaemic goal in people with diabetes in Africa: results from the International Diabetes Management Practices Study (IDMPS)
- Author
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Mbanya, J. C., Aschner, P., Gagliardino, J. J., Ilkova, H., Lavalle, F., Ramachandran, A., Kaddaha, G., Shestakova, M., Chantelot, J. -M, and Chan, J. C. N.
31. Reasons for discontinuation of insulin therapy: results from the International Diabetes Management Practices Study (IDMPS)
- Author
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Chantelot, J. M., Aschner, P., Gagliardino, J. J., Ilkova, H., Lavalle, F., Ramachandran, A., Kaddaha, G., Mbanya, J. C., Shestakova, M., and Chan, J. C. N.
32. Patients’ education, and its impact on care outcomes, resource consumption and working conditions : data from the International Diabetes Management Practices Study (IDMPS)
- Author
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IDMPS investigators, Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Endocrinología, Gagliardino, Juan José, Aschner Montoya, Pablo, Baik, S. H., Chan, J., Chantelot, J. M., Ilkova, H., Ramachandran, Ambady, IDMPS investigators, Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Endocrinología, Gagliardino, Juan José, Aschner Montoya, Pablo, Baik, S. H., Chan, J., Chantelot, J. M., Ilkova, H., and Ramachandran, Ambady
33. Direct gas chromatographic estimation of lower alcohols, acetaldehyde, acetone and diacetyl in milk products
- Author
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Palo, V. and Ilková, H.
- Published
- 1970
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34. Patient-reported outcomes and treatment adherence in type 2 diabetes using natural language processing: Wave 8 of the Observational International Diabetes Management Practices Study.
- Author
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Chan JC, Mbanya JC, Chantelot JM, Shestakova M, Ramachandran A, Ilkova H, Deplante L, Rollot M, Melas-Melt L, Gagliardino JJ, and Aschner P
- Subjects
- Humans, Male, Female, Middle Aged, Surveys and Questionnaires, Aged, Self-Management, Hypoglycemic Agents therapeutic use, Treatment Adherence and Compliance statistics & numerical data, Treatment Adherence and Compliance psychology, Glycated Hemoglobin analysis, Follow-Up Studies, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 therapy, Diabetes Mellitus, Type 2 psychology, Patient Reported Outcome Measures
- Abstract
Aims/introduction: We analyzed patient-reported outcomes of people with type 2 diabetes to better understand perceptions and experiences contributing to treatment adherence., Materials and Methods: In the ongoing International Diabetes Management Practices Study, we collected patient-reported outcomes data from structured questionnaires (chronic treatment acceptance questionnaire and Diabetes Self-Management Questionnaire) and free-text answers to open-ended questions to assess perceptions of treatment value and side-effects, as well as barriers to, and enablers for, adherence and self-management. Free-text answers were analyzed by natural language processing., Results: In 2018-2020, we recruited 2,475 patients with type 2 diabetes (43.3% insulin-treated, glycated hemoglobin (HbA
1c ) 8.0 ± 1.8%; 30.9% with HbA1c <7%) from 13 countries across Africa, the Middle East, Europe, Latin America and Asia. Mean ± standard deviation scores of chronic treatment acceptance questionnaire (acceptance of medication, rated out of 100) and Diabetes Self-Management Questionnaire (self-management, rated out of 10) were 87.8 ± 24.5 and 3.3 ± 0.9, respectively. Based on free-text analysis and coded responses, one in three patients reported treatment non-adherence. Overall, although most patients accepted treatment values and side-effects, self-management was suboptimal. Treatment duration, regimen complexity and disruption of daily routines were major barriers to adherence, whereas habit formation was a key enabler. Treatment-adherent patients were older (60 ± 11.6 vs 55 ± 11.7 years, P < 0.001), and more likely to have longer disease duration (12 ± 8.6 vs 10 ± 7.7 years, P < 0.001), exposure to diabetes education (73.1% vs 67.8%, P < 0.05), lower HbA1c (7.9 ± 1.8% vs 8.3 ± 1.9%, P < 0.001) and attainment of HbA1c <7% (29.7% vs 23.3%, P < 0.01)., Conclusions: Patient perceptions/experiences influence treatment adherence and self-management. Patient-centered education and support programs that consider patient-reported outcomes aimed at promoting empowerment and developing new routines might improve glycemic control., (© 2024 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)- Published
- 2024
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35. Expert Panel Recommendations for Use of Standardized Glucose Reporting System Based on Standardized Glucometrics Plus Visual Ambulatory Glucose Profile (AGP) Data in Clinical Practice.
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Dagdelen S, Deyneli O, Dinccag N, Ilkova H, Osar Siva Z, Yetkin I, and Yilmaz T
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- Diabetes Mellitus metabolism, Disease Management, Glycated Hemoglobin metabolism, Humans, Practice Guidelines as Topic, Blood Glucose metabolism, Blood Glucose Self-Monitoring methods, Diabetes Mellitus therapy, Monitoring, Ambulatory methods, Reference Standards
- Abstract
This expert panel of diabetes specialists aimed to provide guidance to healthcare providers on the best practice in the use of innovative continuous glucose monitoring (CGM) techniques through a practical and implementable document that specifically addresses the rationale for and also analysis and interpretation of the new standardized glucose reporting system based on standardized CGM metrics and visual ambulatory glucose profile (AGP) data. This guidance document presents recommendations and a useful algorithm for the use of a standardized glucose reporting system in the routine diabetes care setting., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Dagdelen, Deyneli, Dinccag, Ilkova, Osar Siva, Yetkin and Yilmaz.)
- Published
- 2022
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36. Status of Weight Change, Lifestyle Behaviors, Depression, Anxiety, and Diabetes Mellitus in a Cohort with Obesity during the COVID-19 Lockdown: Turk-Com Study Group.
- Author
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Yazıcı D, Fersahoğlu MM, Fersahoğlu T, Bulut NE, Çiğiltepe H, Çeler Ö, Sancak S, Sulu C, Durcan E, Şahin S, Polat Korkmaz Ö, Bozdoğan Polat SH, Taşkın E, İşeri C, Gürsoy E, Küçük Yetgin M, Kaya T, Özdemir F, Mestanoğlu İstanbullu N, Kıyıcı S, Öztürk S, Güngör K, Can B, Sargın M, Tabak Z, Averi S, Nazlı A, Polat Y, Akbas F, Tekin S, Topaloğlu Ö, Boz Uzaldı E, Çatalçam S, Bayraktaroğlu T, Çalıkoğlu BF, Nasifova V, Soyluk Selçukbiricik Ö, Karşıdağ K, Sezer H, Özışık S, Bulut H, Bekdemir B, Deyneli O, Dinçer C, Gogas Yavuz D, İlkova H, and Yumuk VD
- Subjects
- Adult, Anxiety epidemiology, Anxiety etiology, Anxiety Disorders epidemiology, Anxiety Disorders etiology, Communicable Disease Control, Depression epidemiology, Depression etiology, Humans, Life Style, Middle Aged, Obesity complications, Obesity epidemiology, Weight Gain, Weight Loss, COVID-19 epidemiology, Diabetes Mellitus epidemiology
- Abstract
Introduction: The coronavirus disease 2019 (COVID-19) pandemic led to a lockdown period. Confinement periods have been related to unhealthy lifestyle behaviors. Our study aimed to determine weight change, changes in eating and exercise habits, the presence of depression and anxiety, and diabetes mellitus (DM) status in a cohort of patients with obesity., Methods: The study was undertaken in nine centers of Collaborative Obesity Management (COM) of the European Association for the Study of Obesity (EASO) in Turkey. An e-survey about weight change, eating habits, physical activity status, DM status, depression, and anxiety was completed by patients. The International Physical Activity Questionnaire (IPAQ) score was used to determine physical activity in terms of metabolic equivalents (METs). A healthy nutrition coefficient was calculated from the different categories of food consumption. The Patient Health Questionnaire (PHQ-9) and General Anxiety Disorder (GAD-7) Questionnaire were used for determining depression and anxiety, respectively., Results: Four hundred twenty-two patients (age 45 ± 12.7 years, W/M = 350/72) were included. The healthy nutrition coefficient before the pandemic was 38.9 ± 6.2 and decreased to 38.1 ± 6.4 during the pandemic (p < 0.001). Two hundred twenty-nine (54.8%) patients gained weight, 54 (12.9%) were weight neutral, and 135 (32.3%) lost weight. Patients in the weight loss group had higher MET scores and higher healthy nutrition coefficients compared with the weight gain and weight-neutral groups (p < 0.001). The PHQ and GAD scores were not different between the groups. Percent weight loss was related to healthy nutrition coefficient (CI: 0.884 [0.821-0.951], p = 0.001) and MET categories (CI: 0.408 [0.222-0.748], p = 0.004). One hundred seventy patients had DM. Considering glycemic control, only 12 (8.4%) had fasting blood glucose <100 mg/dL and 36 (25.2%) had postprandial BG <160 mg/dL. When patients with and without DM were compared in terms of dietary compliance, MET category, weight loss status, PHQ-9 scores, and GAD-7 scores, only MET categories were different; 29 (11.7%) of patients in the nondiabetic group were in the highly active group compared with 5 (2.9%) in the diabetic group., Conclusion: The COVID-19 lockdown resulted in weight gain in about half of our patients, which was related to changes in physical activity and eating habits. Patients with DM who had moderate glycemic control were similar to the general population in terms of weight loss but were less active., (© 2022 The Author(s). Published by S. Karger AG, Basel.)
- Published
- 2022
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37. Screening, prevalence, treatment and control of kidney disease in patients with type 1 and type 2 diabetes in low-to-middle-income countries (2005-2017): the International Diabetes Management Practices Study (IDMPS).
- Author
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Mbanya JC, Aschner P, Gagliardino JJ, İlkova H, Lavalle F, Ramachandran A, Chantelot JM, and Chan JCN
- Subjects
- Adult, Aged, Developing Countries, Diabetes Mellitus, Type 2 drug therapy, Diabetic Nephropathies drug therapy, Female, Humans, Male, Mass Screening, Middle Aged, Prevalence, Treatment Outcome, Young Adult, Diabetes Mellitus, Type 2 epidemiology, Diabetic Nephropathies epidemiology
- Abstract
Aims/hypothesis: Diabetes is the leading cause of kidney disease worldwide. There is limited information on screening, treatment and control of kidney disease in patients with diabetes in low-to-middle-income countries (LMICs)., Methods: The International Diabetes Management Practices Study is an ongoing, non-interventional study of clinical profiles and practices among patients receiving outpatient care mainly by internal medicine physicians and endocrinologists in LMICs. We examined screening, prevalence, treatment and control of kidney disease across seven waves (W) of data collection between 2005 and 2017., Results: Among 15,079 patients with type 1 and 66,088 patients with type 2 diabetes, screening for kidney disease increased between W2 and W3 followed by a plateau (type 1 diabetes: W2, 73.7%; W3, 84.1%; W7, 83.4%; type 2 diabetes: W2, 65.1%; W3, 82.6%; W7, 86.2%). There were also decreasing proportions of patients with microalbuminuria (type 1 diabetes: W1, 27.1%; W3, 14.7%; W7, 13.8%; type 2 diabetes: W1, 24.5%; W3, 12.6%; W7, 11.9%) and proteinuria (type 1 diabetes: W1, 14.2%; W3, 8.7%; W7, 8.2%; type 2 diabetes: W1, 15.6%; W3, 9.3%; W7, 7.6%). Fewer patients were reported as receiving dialysis for both type 1 diabetes (W2, 1.4%; W7, 0.3%) and type 2 diabetes (W2, 0.9%; W7, 0.2%) over time. While there was no change in mean HbA
1c or prevalence of diagnosed hypertension (type 1 diabetes: W1, 22.7%; W7, 19.9%; type 2 diabetes: W1, 60.9%; W7, 66.2%), the use of statins had increased among patients diagnosed with dyslipidaemia (type 1 diabetes: W1, 77.7%; W7, 90.7%; type 2 diabetes: W1, 78.6%; W7, 94.7%). Angiotensin II receptor blockers (type 1 diabetes: W1, 18.0%; W7, 30.6%; type 2 diabetes: W1, 24.2%; W7, 43.6%) were increasingly used over ACE inhibitors after W1 (type 1 diabetes: W1, 65.0%; W7, 55.9%; type 2 diabetes: W1, 55.7%, W7, 41.1%) among patients diagnosed with hypertension., Conclusions/interpretation: In LMICs, real-world data suggest improvement in screening and treatment for kidney disease in patients with type 1 and type 2 diabetes attending non-nephrology clinics. This was accompanied by decreasing proportions of patients with microalbuminuria and proteinuria, with fewer patients who reported receiving dialysis over a 12-year period.- Published
- 2021
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38. One in Seven Insulin-Treated Patients in Developing Countries Reported Poor Persistence with Insulin Therapy: Real World Evidence from the Cross-Sectional International Diabetes Management Practices Study (IDMPS).
- Author
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Chan JCN, Gagliardino JJ, Ilkova H, Lavalle F, Ramachandran A, Mbanya JC, Shestakova M, Dessapt-Baradez C, Chantelot JM, and Aschner P
- Subjects
- Adult, Blood Glucose, Cross-Sectional Studies, Developing Countries, Humans, Hypoglycemic Agents therapeutic use, Insulin, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2 drug therapy
- Abstract
Introduction: Although poor adherence to insulin is widely recognised, periodic discontinuation of insulin may cause more severe hyperglycaemia than poor adherence. We assessed persistence with insulin therapy in patients with type 1 (T1D) or type 2 diabetes (T2D) in developing countries and the reasons for insulin discontinuation., Methods: The International Diabetes Management Practices Study collected real-world data from developing countries in seven waves between 2005 and 2017. In Wave 7 (2016-2017), we asked adult patients with T1D and insulin-treated T2D to report whether they had ever discontinued insulin, the estimated duration of discontinuation and underlying reasons., Results: Among 8303 patients recruited from 24 countries by 620 physicians, 4596 were insulin-treated (T1D: 2000; T2D: 2596). In patients with T1D, 14.0% (95% CI: 12.5-15.6) reported having self-discontinued insulin for a median duration of 1.0 month (IQR: 0.5, 3.5). The respective figures in patients with T2D were 13.7% (12.4-15.1) and 2.0 months (IQR: 1.0, 6.0). The main reasons for discontinuation were impact on social life (T1D: 41.0%; T2D: 30.5%), cost of medications and test strips (T1D: 34.4%; T2D: 24.5%), fear of hypoglycaemia (T1D: 26.7%; T2D: 28.0%) and lack of support (T1D: 26.4%; T2D: 25.9%). Other factors included age < 40 years, non-university education and short disease duration (T1D: ≤ 1 year; T2D: > 1-≤ 5 years). Patients with T1D who did not perform self-monitoring of blood glucose (SMBG) or self-adjust their insulin dosage, and patients with T1D or T2D without glucose meters were less likely to persist with insulin. Nearly 50% of patients who reported poor persistence had HbA
1c > 75 mmol/mol (> 9%) and > 50% of physicians recommended diabetes education programmes to improve treatment persistence., Conclusion: In developing countries, poor persistence with insulin is common among insulin-treated patients, supporting calls for urgent actions to ensure easy access to insulin, tools for SMBG and education.- Published
- 2021
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39. High Prevalence of Depressive Symptoms in Patients With Type 1 and Type 2 Diabetes in Developing Countries: Results From the International Diabetes Management Practices Study.
- Author
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Aschner P, Gagliardino JJ, Ilkova H, Lavalle F, Ramachandran A, Mbanya JC, Shestakova M, Bourhis Y, Chantelot JM, and Chan JCN
- Subjects
- Cross-Sectional Studies, Developing Countries, Female, Humans, Prevalence, Surveys and Questionnaires, Depression epidemiology, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 epidemiology
- Abstract
Objective: Depression is common in people with diabetes, but data from developing countries are scarce. We evaluated the prevalence and risk factors for depressive symptoms in patients with diabetes using data from the International Diabetes Management Practices Study (IDMPS)., Research Design and Methods: IDMPS is an ongoing multinational, cross-sectional study investigating quality of care in patients with diabetes in real-world settings. Data from wave 5 (2011), including 21 countries, were analyzed using the 9-item Patient Health Questionnaire (PHQ-9) to evaluate depressive symptoms. Logistic regression analyses were conducted to identify risk factors of depressive symptoms., Results: Of 9,865 patients eligible for analysis, 2,280 had type 1 and 7,585 had type 2 diabetes (treatment: oral glucose-lowering drugs [OGLD] only, n = 4,729; OGLDs plus insulin, n = 1,892; insulin only, n = 964). Depressive symptoms (PHQ-9 score ≥5) were reported in 30.7% of those with type 1 diabetes. In patients with type 2 diabetes, the respective figures were 29.0% for OGLDs-only, 36.6% for OGLDs-plus-insulin, and 46.7% for insulin-only subgroups. Moderate depressive symptoms (PHQ-9 score 10-19) were observed in 8-16% of patients with type 1 or type 2 diabetes. Female sex, complications, and low socioeconomic status were independently associated with depressive symptoms. In type 1 diabetes and in the type 2 diabetes OGLDs-only group, depression was associated with poor glycemic control., Conclusions: Depressive symptoms are common in patients with diabetes from developing countries, calling for routine screening, especially in high-risk groups, to reduce the double burden of diabetes and depression and their negative interaction., (© 2021 by the American Diabetes Association.)
- Published
- 2021
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40. The Role of Obesity in Predicting the Clinical Outcomes of COVID-19.
- Author
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Sahin S, Sezer H, Cicek E, Yagız Ozogul Y, Yildirim M, Icli TB, Polat Korkmaz O, Durcan E, Sulu C, Somay K, Bekdemir B, Borekci S, Yazici D, Deyneli O, Ergonul O, Tabak F, Dikmen Y, Ozkaya HM, Gonen MS, Damci T, Ilkova H, and Yumuk VD
- Subjects
- Comorbidity, Hospitalization, Humans, Obesity complications, SARS-CoV-2, COVID-19
- Abstract
Introduction: The aim of this was to describe the predictors of mortality related to COVID-19 infection and to evaluate the association between overweight, obesity, and clinical outcomes of COVID-19., Methods: We included the patients >18 years of age, with at least one positive SARS-CoV-2 reverse transcriptase-polymerase chain reaction. Patients were grouped according to body mass index values as normal weight <25 kg/m2 (Group A), overweight from 25 to <30 kg/m2 (Group B), Class I obesity 30 to <35 kg/m2 (Group C), and ≥35 kg/m2 (Group D). Mortality, clinical outcomes, laboratory parameters, and comorbidities were compared among 4 groups., Results: There was no significant difference among study groups in terms of mortality. Noninvasive mechanical ventilation requirement was higher in group B and D than group A, while it was higher in Group D than Group C (Group B vs. Group A [p = 0.017], Group D vs. Group A [p = 0.001], and Group D vs. Group C [p = 0.016]). Lung involvement was less common in Group A, and presence of hypoxia was more common in Group D (Group B vs. Group A [p = 0.025], Group D vs. Group A [p < 0.001], Group D vs. Group B [p = 0.006], and Group D vs. Group C [p = 0.014]). The hospitalization rate was lower in Group A than in the other groups; in addition, patients in Group D have the highest rate of hospitalization (Group B vs. Group A [p < 0.001], Group C vs. Group A [p < 0.001], Group D vs. Group A [p < 0.001], Group D vs. Group B [p < 0.001], and Group D vs. Group C [p = 0.010])., Conclusion: COVID-19 patients with overweight and obesity presented with more severe clinical findings. Health-care providers should take into account that people living with overweight and obesity are at higher risk for COVID-19 and its complications., (© 2021 The Author(s). Published by S. Karger AG, Basel.)
- Published
- 2021
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41. Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries.
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Vaxillaire M, Bonnefond A, Liatis S, Ben Salem Hachmi L, Jotic A, Boissel M, Gaget S, Durand E, Vaillant E, Derhourhi M, Canouil M, Larcher N, Allegaert F, Medlej R, Chadli A, Belhadj A, Chaieb M, Raposo JF, Ilkova H, Loizou D, Lalic N, Vassallo J, Marre M, and Froguel P
- Subjects
- Adult, Female, Humans, Male, Mediterranean Islands epidemiology, Young Adult, Diabetes Mellitus, Type 2 epidemiology
- Abstract
Background: Diagnosis of monogenic diabetes has important clinical implications for treatment and health expenditure. However, its prevalence remains to be specified in many countries, particularly from South Europe, North Africa and Middle-East, where non-autoimmune diabetes in young adults is increasing dramatically., Aims: To identify cases of monogenic diabetes in young adults from Mediterranean countries and assess the specificities between countries., Methods: We conducted a transnational multicenter study based on exome sequencing in 204 unrelated patients with diabetes (age-at-diagnosis: 26.1 ± 9.1 years). Rare coding variants in 35 targeted genes were evaluated for pathogenicity. Data were analyzed using one-way ANOVA, chi-squared test and factor analysis of mixed data., Results: Forty pathogenic or likely pathogenic variants, 14 of which novel, were identified in 36 patients yielding a genetic diagnosis rate of 17.6%. The majority of cases were due to GCK, HNF1A, ABCC8 and HNF4A variants. We observed highly variable diagnosis rates according to countries, with association to genetic ancestry. Lower body mass index and HbA1c at study inclusion, and less frequent insulin treatment were hallmarks of pathogenic variant carriers. Treatment changes following genetic diagnosis have been made in several patients., Conclusions: Our data from patients in several Mediterranean countries highlight a broad clinical and genetic spectrum of diabetes, showing the relevance of wide genetic testing for personalized care of early-onset diabetes., Competing Interests: Declaration of Competing Interest Prof. M. Marre reports personal fees from Abbott, Intarcia, Eli Lilly, MSD, Novo Nordisk, Sanofi and Servier, grants from Novo Nordisk, Sanofi, Servier, MSD and Novartis, and nonfinancial support from Novo Nordisk. No other potential conflicts of interest relevant to this article were reported., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2021
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42. Correction to: Persistent poor glycaemic control in individuals with type 2 diabetes in developing countries: 12 years of real-world evidence of the International Diabetes Management Practices Study (IDMPS).
- Author
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Aschner P, Gagliardino JJ, Ilkova H, Lavalle F, Ramachandran A, Mbanya JC, Shestakova M, Chantelot JM, and Chan JCN
- Abstract
Unfortunately, the standard deviations for 'last HbA
1c measurement' in mmol/mol were miscalculated in Table 1 of this paper.- Published
- 2020
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43. Persistent poor glycaemic control in individuals with type 2 diabetes in developing countries: 12 years of real-world evidence of the International Diabetes Management Practices Study (IDMPS).
- Author
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Aschner P, Gagliardino JJ, Ilkova H, Lavalle F, Ramachandran A, Mbanya JC, Shestakova M, Chantelot JM, and Chan JCN
- Subjects
- Adult, Aged, Blood Glucose drug effects, Blood Glucose metabolism, Cross-Sectional Studies, Diabetes Mellitus, Type 2 drug therapy, Female, Glycated Hemoglobin drug effects, Humans, Hypoglycemic Agents therapeutic use, Male, Medication Adherence statistics & numerical data, Middle Aged, Patient Outcome Assessment, Self-Management statistics & numerical data, Self-Management trends, Developing Countries statistics & numerical data, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 epidemiology, Glycated Hemoglobin metabolism, Glycemic Control statistics & numerical data, Glycemic Control trends
- Abstract
Aims/hypothesis: We evaluated the secular trend of glycaemic control in individuals with type 2 diabetes in developing countries, where data are limited., Methods: The International Diabetes Management Practices Study provides real-world evidence of patient profiles and diabetes care practices in developing countries in seven cross-sectional waves (2005-2017). At each wave, each physician collected data from ten consecutive participants with type 2 diabetes during a 2 week period. The primary objective of this analysis was to evaluate trends of glycaemic control over time., Results: A total of 66,088 individuals with type 2 diabetes were recruited by 6099 physicians from 49 countries. The proportion of participants with HbA
1c <53 mmol/mol (<7%) decreased from 36% in wave 1 (2005) to 30.1% in wave 7 (2017) (p < 0.0001). Compared with wave 1, the adjusted ORs of attaining HbA1c ≤64 mmol/mol (≤8%) decreased significantly in waves 2, 5, 6 and 7 (p < 0.05). Over 80% of participants received oral glucose-lowering drugs, with declining use of sulfonylureas. Insulin use increased from 32.8% (wave 1) to 41.2% (wave 7) (p < 0.0001). The corresponding time to insulin initiation (mean ± SD) changed from 8.4 ± 6.9 in wave 1 to 8.3 ± 6.6 years in wave 7, while daily insulin dosage ranged from 0.39 ± 0.21 U/kg (wave 1) to 0.33 ± 0.19 U/kg (wave 7) for basal regimen and 0.70 ± 0.34 U/kg (wave 1) to 0.77 ± 0.33 (wave 7) U/kg for basal-bolus regimen. An increasing proportion of participants had ≥2 HbA1c measurements within 12 months of enrolment (from 61.8% to 92.9%), and the proportion of participants receiving diabetes education (mainly delivered by physicians) also increased from 59.0% to 78.3%., Conclusions: In developing countries, glycaemic control in individuals with type 2 diabetes remained suboptimal over a 12 year period, indicating a need for system changes and better organisation of care to improve self-management and attainment of treatment goals.- Published
- 2020
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44. Diabetes education and health insurance: How they affect the quality of care provided to people with type 1 diabetes in Latin America. Data from the International Diabetes Mellitus Practices Study (IDMPS).
- Author
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Gagliardino JJ, Chantelot JM, Domenger C, Ilkova H, Ramachandran A, Kaddaha G, Claude Mbanya J, Chan J, and Aschner P
- Subjects
- Adult, Cross-Sectional Studies, Diabetes Mellitus, Type 1 pathology, Female, Humans, Latin America, Male, Diabetes Mellitus, Type 1 therapy, Health Education methods, Insurance, Health standards, Quality of Health Care standards
- Abstract
Aims: This study aimed to evaluate the impact of diabetes education and access to healthcare coverage on disease management and outcomes in Latin America., Methods: Data were obtained from a sub-analysis of 2693 patients with type 1 diabetes mellitus recruited from 9 Latin American countries as part of the International Diabetes Mellitus Practices Study (IDMPS), a multinational, observational survey of diabetes treatment in developing regions., Results: Results from the Latin American cohort show that only 25% of participants met HbA1c target value (< 7% [53 mmol/mol]). Attainment of this target was significantly higher among participants who had received diabetes education than those who hadn't (28% vs. 19%, p < 0.001), and among those who practiced self-management (27% vs. 21% no self-management, p = 0.001). Multivariate analysis showed that participants who had received diabetes education were more likely to manage their diabetes (OR:1.65 [95% CI: 1.24, 2.19]; p = 0.001), and to attain HbA1c target values (OR:1.48 [95% CI: 1.14, 1.93]; p = 0.003)., Conclusions: Given the association between uncontrolled diabetes and long-term complications, health authorities and care providers should increase efforts to ensure widespread healthcare coverage and access to self-management education to reduce the socioeconomic and humanistic burden of type 1 diabetes., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2019
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45. Introduction to the 5th World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy).
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Raz I, Cefalu WT, Ilkova H, and Del Prato S
- Subjects
- Cardiovascular Diseases etiology, Cardiovascular Diseases prevention & control, Congresses as Topic, Consensus, Diabetes Mellitus, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 prevention & control, Diabetic Angiopathies etiology, Diabetic Angiopathies prevention & control, Humans, Hypertension complications, Obesity complications, Diabetes Mellitus, Type 2 drug therapy, Hypertension therapy, Obesity therapy
- Published
- 2016
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46. Effect of valsartan on the incidence of diabetes and cardiovascular events.
- Author
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McMurray JJ, Holman RR, Haffner SM, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamás G, Tognoni G, Tuomilehto J, Villamil AS, Vozár J, and Califf RM
- Subjects
- Angiotensin II Type 1 Receptor Blockers adverse effects, Blood Glucose analysis, Blood Glucose drug effects, Blood Pressure drug effects, Body Weight drug effects, Cardiovascular Diseases epidemiology, Cardiovascular Diseases mortality, Cyclohexanes therapeutic use, Diabetes Mellitus, Type 2 epidemiology, Double-Blind Method, Drug Therapy, Combination, Exercise, Female, Follow-Up Studies, Glucose Intolerance diet therapy, Glucose Intolerance therapy, Humans, Hypoglycemic Agents therapeutic use, Incidence, Male, Middle Aged, Nateglinide, Phenylalanine analogs & derivatives, Phenylalanine therapeutic use, Proportional Hazards Models, Risk Factors, Tetrazoles adverse effects, Valine adverse effects, Valine therapeutic use, Valsartan, Angiotensin II Type 1 Receptor Blockers therapeutic use, Cardiovascular Diseases prevention & control, Diabetes Mellitus, Type 2 prevention & control, Glucose Intolerance drug therapy, Tetrazoles therapeutic use, Valine analogs & derivatives
- Abstract
Background: It is not known whether drugs that block the renin-angiotensin system reduce the risk of diabetes and cardiovascular events in patients with impaired glucose tolerance., Methods: In this double-blind, randomized clinical trial with a 2-by-2 factorial design, we assigned 9306 patients with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors to receive valsartan (up to 160 mg daily) or placebo (and nateglinide or placebo) in addition to lifestyle modification. We then followed the patients for a median of 5.0 years for the development of diabetes (6.5 years for vital status). We studied the effects of valsartan on the occurrence of three coprimary outcomes: the development of diabetes; an extended composite outcome of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure, arterial revascularization, or hospitalization for unstable angina; and a core composite outcome that excluded unstable angina and revascularization., Results: The cumulative incidence of diabetes was 33.1% in the valsartan group, as compared with 36.8% in the placebo group (hazard ratio in the valsartan group, 0.86; 95% confidence interval [CI], 0.80 to 0.92; P<0.001). Valsartan, as compared with placebo, did not significantly reduce the incidence of either the extended cardiovascular outcome (14.5% vs. 14.8%; hazard ratio, 0.96; 95% CI, 0.86 to 1.07; P=0.43) or the core cardiovascular outcome (8.1% vs. 8.1%; hazard ratio, 0.99; 95% CI, 0.86 to 1.14; P=0.85)., Conclusions: Among patients with impaired glucose tolerance and cardiovascular disease or risk factors, the use of valsartan for 5 years, along with lifestyle modification, led to a relative reduction of 14% in the incidence of diabetes but did not reduce the rate of cardiovascular events. (ClinicalTrials.gov number, NCT00097786.), (2010 Massachusetts Medical Society)
- Published
- 2010
- Full Text
- View/download PDF
47. Effect of nateglinide on the incidence of diabetes and cardiovascular events.
- Author
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Holman RR, Haffner SM, McMurray JJ, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamás G, Tognoni G, Tuomilehto J, Villamil AS, Vozár J, and Califf RM
- Subjects
- Angiotensin II Type 1 Receptor Blockers therapeutic use, Blood Glucose analysis, Blood Glucose drug effects, Body Weight drug effects, Cardiovascular Diseases epidemiology, Cardiovascular Diseases mortality, Cyclohexanes adverse effects, Diabetes Mellitus, Type 2 epidemiology, Double-Blind Method, Drug Therapy, Combination, Exercise, Female, Follow-Up Studies, Glucose Intolerance diet therapy, Glucose Intolerance therapy, Humans, Hypoglycemic Agents adverse effects, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Nateglinide, Phenylalanine adverse effects, Phenylalanine therapeutic use, Proportional Hazards Models, Risk Factors, Tetrazoles therapeutic use, Treatment Failure, Valine analogs & derivatives, Valine therapeutic use, Valsartan, Cardiovascular Diseases prevention & control, Cyclohexanes therapeutic use, Diabetes Mellitus, Type 2 prevention & control, Glucose Intolerance drug therapy, Hypoglycemic Agents therapeutic use, Phenylalanine analogs & derivatives
- Abstract
Background: The ability of short-acting insulin secretagogues to reduce the risk of diabetes or cardiovascular events in people with impaired glucose tolerance is unknown., Methods: In a double-blind, randomized clinical trial, we assigned 9306 participants with impaired glucose tolerance and either cardiovascular disease or cardiovascular risk factors to receive nateglinide (up to 60 mg three times daily) or placebo, in a 2-by-2 factorial design with valsartan or placebo, in addition to participation in a lifestyle modification program. We followed the participants for a median of 5.0 years for incident diabetes (and a median of 6.5 years for vital status). We evaluated the effect of nateglinide on the occurrence of three coprimary outcomes: the development of diabetes; a core cardiovascular outcome that was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure; and an extended cardiovascular outcome that was a composite of the individual components of the core composite cardiovascular outcome, hospitalization for unstable angina, or arterial revascularization., Results: After adjustment for multiple testing, nateglinide, as compared with placebo, did not significantly reduce the cumulative incidence of diabetes (36% and 34%, respectively; hazard ratio, 1.07; 95% confidence interval [CI], 1.00 to 1.15; P=0.05), the core composite cardiovascular outcome (7.9% and 8.3%, respectively; hazard ratio, 0.94, 95% CI, 0.82 to 1.09; P=0.43), or the extended composite cardiovascular outcome (14.2% and 15.2%, respectively; hazard ratio, 0.93, 95% CI, 0.83 to 1.03; P=0.16). Nateglinide did, however, increase the risk of hypoglycemia., Conclusions: Among persons with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors, assignment to nateglinide for 5 years did not reduce the incidence of diabetes or the coprimary composite cardiovascular outcomes. (ClinicalTrials.gov number, NCT00097786.), (2010 Massachusetts Medical Society)
- Published
- 2010
- Full Text
- View/download PDF
48. Serum levels of p53 and cytochrome c in subjects with type 2 diabetes and impaired glucose tolerance.
- Author
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Dincer Y, Himmetoglu S, Yalin S, Damci T, Ilkova H, and Akcay T
- Subjects
- Adult, Aged, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Cytochromes c blood, Diabetes Mellitus, Type 2 blood, Glucose Intolerance blood, Tumor Suppressor Protein p53 blood
- Abstract
Purpose: To examine apoptotic markers in serum of subjects with diabetes and impaired glucose tolerance (IGT). Serum levels of p53 and cytochrome c, regulator molecules for apoptosis, were measured in subjects with type 2 diabetes, subjects with IGT and healthy controls., Methods: Forty one subjects with type 2 diabetes, 27 with IGT and 27 healthy volunteers were included in the study. Serum level of cytochrome c and p53 were measured with competitive ELISA., Results: Serum levels of p53 were lower in the group of subjects with type 2 diabetes (085+/-0.39 U/ml) than in controls (1.09+/-0.49 U/ml) (P < 0.05) and in the subjects with IGT (0.98+/-0.37 U/ml) (P < 0.05). There was no significant difference between the group with IGT and controls. Also, there was no difference for serum level of cytochrome c among the groups. In the group of subjects with type 2 diabetes, serum level of cytochrome c was mildly correlated with HbA1c (r:0.39, P < 0.05)., Conclusion: The present study shows that the serum level of p53 is lower in the patients with type 2 diabetes than in controls or in subjects with IGT. No difference was seen among the the groups for the serum level of cytochrome c.
- Published
- 2009
- Full Text
- View/download PDF
49. Celiac disease in an adult Turkish population with type 1 diabetes mellitus.
- Author
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Aygun C, Uraz S, Damci T, Osar Z, Yumuk V, Akdenizli E, and Ilkova H
- Subjects
- Adult, Body Mass Index, Celiac Disease complications, Celiac Disease diagnosis, Connective Tissue immunology, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 pathology, Female, Humans, Immunoglobulin A blood, Male, Prevalence, Severity of Illness Index, Turkey epidemiology, Celiac Disease epidemiology, Diabetes Mellitus, Type 1 complications
- Abstract
Celiac disease is a frequent cause of morbidity among patients with type 1 diabetes mellitus. In this study our objective was to determine the prevalance of celiac diasease in a Turkish adult population with type 1 diabetes mellitus. Patients included 122 type 1 diabetes cases from adult diabetes clinic. Total IgA and IgA-antiendomysial antibody (AEA) assays were performed. Patients positive for IgA-AEA were asked to undergo small intestinal biopsy. Of the 122 patients, none was IgA deficient and 3 had positive IgA-AEA results (2.45%). All three of these patients had biopsies diagnostic of celiac disease. The body mass index (BMI) values of patients with positive AEA were significantly lower than normal (P = 0.024). Among the gastrointestinal complaints there was an association between early satiety and AEA positivity (P = 0.02). None of the other gastrointestinal complaints or age, duration of diabetes, glycosylated hemoglobin values, or insulin doses used were found to be related to AEA positivity. Celiac disease has a high prevalence among Turkish paients with type 1 diabetes mellitus. Screening for IgA-AEA during routine investigations of type 1 diabetic patients is important to prevent celiac-associated symptoms.
- Published
- 2005
- Full Text
- View/download PDF
50. Nicotinamide effects oxidative burst activity of neutrophils in patients with poorly controlled type 2 diabetes mellitus.
- Author
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Osar Z, Samanci T, Demirel GY, Damci T, and Ilkova H
- Subjects
- Blood Glucose drug effects, Blood Glucose metabolism, Body Mass Index, Diabetes Mellitus, Type 2 drug therapy, Female, Humans, Hypoglycemic Agents therapeutic use, Male, Middle Aged, Neutrophils drug effects, Phagocytosis drug effects, Reference Values, Respiratory Burst physiology, Diabetes Mellitus, Type 2 blood, Neutrophils physiology, Niacinamide pharmacology, Respiratory Burst drug effects
- Abstract
Neutrophil functions are impaired in patients with diabetes mellitus. Bacterial phagocytosis and oxidative burst activity are reduced at high glucose concentrations in diabetic patients. Defects in neutrophil oxidative burst capacity are of multifactorial origin in diabetes mellitus and correlate with glucose levels. It has been reported that neutrophil NADPH oxidase activity is impaired and superoxide production is reduced in diabetic patients with or without any infections. Nicotinamide is a vitamin B3 derivative and a NAD precursor with immunomodulatory effects. In vitro studies demonstrated that nicotinamide increases NAD and NADH content of beta cells. The authors hypothesized that nicotinamide may restore the impaired oxidative burst capacity of neutrophils in diabetic patients by increasing the NADH content as an electron donor and possibly through NADPH oxidase activity of the cell. In order to test the hypothesis, this placebo-controlled and open study was designed to evaluate neutrophil functions in infection-free poorly controlled type 2 diabetic patients as compared to healthy subjects and assess the effects of nicotinamide on neutrophil phagocytosis as well as oxidative burst activity. Thirty patients with type 2 diabetes mellitus were enrolled in the study. Sixteen were females and 14 were males, with a mean age 58 +/- 10. All patients were on sulphonylurea treatment and their hemoglobin A(1c) (HbA(1c)) levels were above 7.5%. The control group consisted of 10 voluntary healthy subjects. Diabetic and control subjects were not significantly different in terms of age, body mass index (BMI), leucocyte and neutrophil counts, C-reactive protein (CRP) level, and erythrocyte sedimentation rate (ESR), but HbA(1c) and fasting glucose levels were significantly higher in patients with diabetes mellitus. Phagocytic activity and respiratory burst indexes were measured by flow cytometric analyses as previously described by Rothe and Valet (Methods Enzyml., 233, 539-548, 1994) and compared in diabetic subjects and healthy controls. Diabetic patients were grouped to receive either 50 mg/kg oral nicotinamide (n = 15) or placebo (n = 15) for a period of 1 month. The 2 groups did not differ in terms of treatment, frequency of hypertension, BMI, diabetes duration, age, fasting plasma glucose (FPG), HbA(1c), CRP, ESR, polymorphonuclear leukocyte (PNL) and neutrophil counts. Neutrophil functions were reassessed after the treatment period. Phagocytic activity represented as indexes were lower in diabetic patients when compared to healthy subjects, but the differences were not statistically significant (P >.05). Patients with diabetes mellitus had significantly lower oxidative burst indexes when compared to healthy controls (P values <.05). In diabetic patients, a negative correlation between neutrophil functions and HbA(1c) was found which was not statistically significant (P values >.05). Phagocytic indexes were similar in nicotinamide and placebo groups after treatment period (P >.05). But oxidative burst activity in patients receiving nicotinamide was greater when compared with placebo and the difference was statistically significant at 30 and 45 minutes (P values.04 and.03). This effect of nicotinamide may be due to increased NADH content and NADPH oxidase activity of the cell, which needs to be further studied. Impaired neutrophil functions may aggravate various infections in patients with diabetes mellitus and blood glucose regulation is an important target of treatment to improve neutrophil functions. But nicotinamide treatment may help to improve prognosis in diabetic patients with severe infections.
- Published
- 2004
- Full Text
- View/download PDF
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