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Abstract Interleukin-10 (IL-10) is an immunomodulatory cytokine that plays a pivotal role in the pathogenesis of acute coronary syndromes (ACS). Here, we evaluated the role of IL10 promoter variants as markers for ACS susceptibility in Western Mexican patients as well as its association with IL10 mRNA and IL-10 plasma levels. Three promoter variants (− 1082 A > G, − 819 T > C and − 592 A > C) were analyzed in 300 ACS patients and 300 control group (CG) individuals. IL10 relative gene expression was evaluated in peripheral blood mononuclear cells (PBMC) and IL-10 levels were quantified in plasma. The allelic, genotypic and haplotypic frequencies did not show significant differences between groups. ACS patients had sevenfold higher mRNA IL10 level compared to CG (p = 0.0013). Homozygous C/C carriers in both − 819 T > C and − 592 A > C variants had 0.4-fold higher IL10 mRNA expression than heterozygous and polymorphic allele homozygous genotypes (p = 0.0357) in ACS group. There were significant differences in plasma IL-10 levels in CG and ACS group (1.001 vs 1.777 pg/mL, p = 0.0051). The variants were not markers of susceptibility to ACS in Western Mexican individuals. ACS patients showed higher IL10 expression than CG individuals which could be mediated by − 819 T > C and − 592 A > C variants and pharmacotherapy.

Introduction: Domestic violence is one of the most frequent health problems today, it is not always reported, since fear prevails in the attacked people. Objective: Describe the effects of domestic violence in pediatric ages. Method: A descriptive, retros-pective study was carried out at the Hermanos Cordové Provincial Hospital, during the months of January 2021 to January 2022. The population was 213 records using intentional sampling, 91 records of patients who attended in the indicated period were selected; The reason for consultation was that his condition was caused or a consequence of domestic violence. The variables measured: age, sex, type of violence against the child and the consequences. Descriptive statistics were applied to analyze the data. Results: Physical violence predominated in 47.2% (43), 67% (61) were female, and 51.7% (47) were in the 15-19 age group. The conse-quences found were: difficulty falling asleep and eating disorders in preschool patients (1-4 years) 7.7% (7), aggressiveness 16.4% (15) for the group of schoolchildren (5-14), lack of appetite and anorexia in adolescents (15-19) 23.0 % (21). Discussion: Patients affected by violence may present aggression, difficulty socializing and expressing themselves, as well as manifest difficulty in lear-ning as a result of damage to motor development, psychological and intellectual. The affected person’s self-esteem is reduced and there are problems with eating or sleeping.