1. Tuning magnetic relaxation properties of 'hard cores' in core-shell colloids by modification of 'soft shell'
- Author
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Asiya R. Mustafina, Marsil K. Kadirov, Rustem Zairov, Aidar T. Gubaidullin, Sergey N. Podyachev, Irek R. Nizameev, Ildus Ismayev, Timur A. Mukhametzyanov, Alsu R. Mukhametshina, Alexandra D. Voloshina, and Nataliya Shamsutdinova
- Subjects
Luminescence ,Materials science ,Cell Survival ,Shell (structure) ,Contrast Media ,Gadolinium ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Cell Line ,Colloid ,Colloid and Surface Chemistry ,Magnetic relaxation ,Colloids ,Physical and Theoretical Chemistry ,Isostructural ,Terbium ,Aqueous solution ,Scattering ,Serum Albumin, Bovine ,Surfaces and Interfaces ,General Medicine ,Fibroblasts ,021001 nanoscience & nanotechnology ,Magnetic Resonance Imaging ,Polyelectrolytes ,Polyelectrolyte ,0104 chemical sciences ,Solutions ,Chemical physics ,0210 nano-technology ,Hydrophobic and Hydrophilic Interactions ,Biotechnology - Abstract
The present work introduces an impact of polyelectrolyte-based hydrophilic shell on magnetic relaxivity and luminescence of hard cores built from isostructural complexes of Tb(III) and Gd(III) in the core-shell aqueous colloids. Microscopic and scattering techniques reveal "plum pudding" morphology of the colloids, where polyelectrolyte-coated ultrasmall (5nm) hard cores form aggregates in aqueous solutions. Interaction of bovine serum albumin (BSA) with the colloids provides a tool to modify the polyelectrolyte-based shell, which is the reason for the improvement in both aggregation behavior of the colloids and their relaxivity. The modification of the hydrophilic polyelectrolyte-based shell enables to tune the longitudinal relaxivity from 5.9 to 23.3mM
- Published
- 2018
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