Search

Your search keyword '"Ilardi, F."' showing total 147 results
Start Over Author "Ilardi, F."
147 results on '"Ilardi, F."'

1. Organization and Activity of Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging

Author

Ciampi, Q, Pepi, M, Antonini-Canterin, F, Barbieri, A, Barchitta, A, Faganello, G, Miceli, S, Parato, V, Tota, A, Trocino, G, Abbate, M, Accadia, M, Alemanni, R, Angelini, A, Anglano, F, Anselmi, M, Aquila, I, Aramu, S, Avogadri, E, Azzaro, G, Badano, L, Balducci, A, Ballocca, F, Barbarossa, A, Barbati, G, Barletta, V, Barone, D, Becherini, F, Benfari, G, Beraldi, M, Bergandi, G, Bilardo, G, Binno, S, Bolognesi, M, Bongiovi, S, Bragato, R, Braggion, G, Brancaleoni, R, Bursi, F, Dessalvi, C, Cameli, M, Canu, A, Capitelli, M, Capra, A, Carbonara, R, Carbone, M, Carbonella, M, Carrabba, N, Casavecchia, G, Casula, M, Chesi, E, Cicco, S, Citro, R, Cocchia, R, Colombo, B, Colonna, P, Conte, M, Corrado, G, Cortesi, P, Cortigiani, L, Costantino, M, Cozza, F, Cucchini, U, D'Angelo, M, Ros, S, D'Andrea, F, D'Andrea, A, D'Auria, F, De Caridi, G, De Feo, S, De Matteis, G, De Vecchi, S, Del Giudice, C, Dell'Angela, L, Delli Paoli, L, Dentamaro, I, Destefanis, P, Di Fulvio, M, Di Gaetano, R, Di Giannuario, G, Di Gioia, A, Di Martino, L, Di Muro, C, Di Nora, C, Di Salvo, G, Dodi, C, Dogliani, S, Donati, F, Dottori, M, Epifani, G, Fabiani, I, Ferrara, F, Ferrara, L, Ferrua, S, Filice, G, Fiorino, M, Forno, D, Garini, A, Giarratana, G, Gigantino, G, Giorgi, M, Giubertoni, E, Greco, C, Grigolato, M, Marra, W, Holzl, A, Iaiza, A, Iannaccone, A, Ilardi, F, Imbalzano, E, Inciardi, R, Inserra, C, Iori, E, Izzo, A, La Rosa, G, Labanti, G, Lanzone, A, Lanzoni, L, Lapetina, O, Leiballi, E, Librera, M, Lo Conte, C, Lo Monaco, M, Lombardo, A, Luciani, M, Lusardi, P, Magnante, A, Malagoli, A, Malatesta, G, Mancusi, C, Manes, M, Manganelli, F, Mantovani, F, Manuppelli, V, Marchese, V, Marinacci, L, Mattioli, R, Maurizio, C, Mazza, G, Mazza, S, Melis, M, Meloni, G, Merli, E, Milan, A, Minardi, G, Monaco, A, Monte, I, Montresor, G, Moreo, A, Mori, F, Morini, S, Moro, C, Morrone, D, Negri, F, Nipote, C, Nisi, F, Nocco, S, Novello, L, Nunziata, L, Perini, A, Parodi, A, Pasanisi, E, Pastorini, G, Pavasini, R, Pavoni, D, Pedone, C, Pelliccia, F, Pelliciari, G, Pelloni, E, Pergola, V, Perillo, G, Petruccelli, E, Pezzullo, C, Piacentini, G, Picardi, E, Pinna, G, Pizzarelli, M, Pizzuti, A, Poggi, M, Posteraro, A, Privitera, C, Rampazzo, D, Ratti, C, Rettegno, S, Ricci, F, Ricci, C, Rolando, C, Rossi, S, Rovera, C, Ruggieri, R, Russo, M, Sacchi, N, Saladino, A, Sani, F, Sartori, C, Scarabeo, V, Sciacqua, A, Scillone, A, Scopelliti, P, Scorza, A, Scozzafava, A, Serafini, F, Serra, W, Severino, S, Simeone, B, Sirico, D, Solari, M, Spadaro, G, Stefani, L, Strangio, A, Surace, F, Tamborini, G, Tarquinio, N, Tassone, E, Tavarozzi, I, Tchana, B, Tedesco, G, Tinto, M, Torzillo, D, Totaro, A, Triolo, O, Troisi, F, Tusa, M, Vancheri, F, Varasano, V, Venezia, A, Vermi, A, Villari, B, Zampi, G, Zannoni, J, Zito, C, Zugaro, A, Di Bella, G, Carerj, S, Ciampi Q., Pepi M., Antonini-Canterin F., Barbieri A., Barchitta A., Faganello G., Miceli S., Parato V. M., Tota A., Trocino G., Abbate M., Accadia M., Alemanni R., Angelini A., Anglano F., Anselmi M., Aquila I., Aramu S., Avogadri E., Azzaro G., Badano L., Balducci A., Ballocca F., Barbarossa A., Barbati G., Barletta V., Barone D., Becherini F., Benfari G., Beraldi M., Bergandi G., Bilardo G., Binno S. M., Bolognesi M., Bongiovi S., Bragato R. M., Braggion G., Brancaleoni R., Bursi F., Dessalvi C. C., Cameli M., Canu A., Capitelli M., Capra A. C. M., Carbonara R., Carbone M., Carbonella M., Carrabba N., Casavecchia G., Casula M., Chesi E., Cicco S., Citro R., Cocchia R., Colombo B. M., Colonna P., Conte M., Corrado G., Cortesi P., Cortigiani L., Costantino M. F., Cozza F., Cucchini U., D'Angelo M., Ros S. D., D'Andrea F., D'Andrea A., D'Auria F., De Caridi G., De Feo S., De Matteis G. M., De Vecchi S., Del Giudice C., Dell'Angela L., Delli Paoli L., Dentamaro I., Destefanis P., Di Fulvio M., Di Gaetano R., Di Giannuario G., Di Gioia A., Di Martino L. F. M., Di Muro C., Di Nora C., Di Salvo G., Dodi C., Dogliani S., Donati F., Dottori M., Epifani G., Fabiani I., Ferrara F., Ferrara L., Ferrua S., Filice G., Fiorino M., Forno D., Garini A., Giarratana G. A., Gigantino G., Giorgi M., Giubertoni E., Greco C. A., Grigolato M., Marra W. G., Holzl A., Iaiza A., Iannaccone A., Ilardi F., Imbalzano E., Inciardi R., Inserra C. A., Iori E., Izzo A., La Rosa G., Labanti G., Lanzone A. M., Lanzoni L., Lapetina O., Leiballi E., Librera M., Lo Conte C., Lo Monaco M., Lombardo A., Luciani M., Lusardi P., Magnante A., Malagoli A., Malatesta G., Mancusi C., Manes M. T., Manganelli F., Mantovani F., Manuppelli V., Marchese V., Marinacci L., Mattioli R., Maurizio C., Mazza G. A., Mazza S., Melis M., Meloni G., Merli E., Milan A., Minardi G., Monaco A., Monte I., Montresor G., Moreo A., Mori F., Morini S., Moro C., Morrone D., Negri F., Nipote C., Nisi F., Nocco S., Novello L., Nunziata L., Perini A. P., Parodi A., Pasanisi E. M., Pastorini G., Pavasini R., Pavoni D., Pedone C., Pelliccia F., Pelliciari G., Pelloni E., Pergola V., Perillo G., Petruccelli E., Pezzullo C., Piacentini G., Picardi E., Pinna G., Pizzarelli M., Pizzuti A., Poggi M. M., Posteraro A., Privitera C., Rampazzo D., Ratti C., Rettegno S., Ricci F., Ricci C., Rolando C., Rossi S., Rovera C., Ruggieri R., Russo M. G., Sacchi N., Saladino A., Sani F., Sartori C., Scarabeo V., Sciacqua A., Scillone A., Scopelliti P. A., Scorza A., Scozzafava A., Serafini F., Serra W., Severino S., Simeone B., Sirico D., Solari M., Spadaro G. L., Stefani L., Strangio A., Surace F. C., Tamborini G., Tarquinio N., Tassone E. J., Tavarozzi I., Tchana B., Tedesco G., Tinto M., Torzillo D., Totaro A., Triolo O. F., Troisi F., Tusa M., Vancheri F., Varasano V., Venezia A., Vermi A. C., Villari B., Zampi G., Zannoni J., Zito C., Zugaro A., Di Bella G., Carerj S., Ciampi, Q, Pepi, M, Antonini-Canterin, F, Barbieri, A, Barchitta, A, Faganello, G, Miceli, S, Parato, V, Tota, A, Trocino, G, Abbate, M, Accadia, M, Alemanni, R, Angelini, A, Anglano, F, Anselmi, M, Aquila, I, Aramu, S, Avogadri, E, Azzaro, G, Badano, L, Balducci, A, Ballocca, F, Barbarossa, A, Barbati, G, Barletta, V, Barone, D, Becherini, F, Benfari, G, Beraldi, M, Bergandi, G, Bilardo, G, Binno, S, Bolognesi, M, Bongiovi, S, Bragato, R, Braggion, G, Brancaleoni, R, Bursi, F, Dessalvi, C, Cameli, M, Canu, A, Capitelli, M, Capra, A, Carbonara, R, Carbone, M, Carbonella, M, Carrabba, N, Casavecchia, G, Casula, M, Chesi, E, Cicco, S, Citro, R, Cocchia, R, Colombo, B, Colonna, P, Conte, M, Corrado, G, Cortesi, P, Cortigiani, L, Costantino, M, Cozza, F, Cucchini, U, D'Angelo, M, Ros, S, D'Andrea, F, D'Andrea, A, D'Auria, F, De Caridi, G, De Feo, S, De Matteis, G, De Vecchi, S, Del Giudice, C, Dell'Angela, L, Delli Paoli, L, Dentamaro, I, Destefanis, P, Di Fulvio, M, Di Gaetano, R, Di Giannuario, G, Di Gioia, A, Di Martino, L, Di Muro, C, Di Nora, C, Di Salvo, G, Dodi, C, Dogliani, S, Donati, F, Dottori, M, Epifani, G, Fabiani, I, Ferrara, F, Ferrara, L, Ferrua, S, Filice, G, Fiorino, M, Forno, D, Garini, A, Giarratana, G, Gigantino, G, Giorgi, M, Giubertoni, E, Greco, C, Grigolato, M, Marra, W, Holzl, A, Iaiza, A, Iannaccone, A, Ilardi, F, Imbalzano, E, Inciardi, R, Inserra, C, Iori, E, Izzo, A, La Rosa, G, Labanti, G, Lanzone, A, Lanzoni, L, Lapetina, O, Leiballi, E, Librera, M, Lo Conte, C, Lo Monaco, M, Lombardo, A, Luciani, M, Lusardi, P, Magnante, A, Malagoli, A, Malatesta, G, Mancusi, C, Manes, M, Manganelli, F, Mantovani, F, Manuppelli, V, Marchese, V, Marinacci, L, Mattioli, R, Maurizio, C, Mazza, G, Mazza, S, Melis, M, Meloni, G, Merli, E, Milan, A, Minardi, G, Monaco, A, Monte, I, Montresor, G, Moreo, A, Mori, F, Morini, S, Moro, C, Morrone, D, Negri, F, Nipote, C, Nisi, F, Nocco, S, Novello, L, Nunziata, L, Perini, A, Parodi, A, Pasanisi, E, Pastorini, G, Pavasini, R, Pavoni, D, Pedone, C, Pelliccia, F, Pelliciari, G, Pelloni, E, Pergola, V, Perillo, G, Petruccelli, E, Pezzullo, C, Piacentini, G, Picardi, E, Pinna, G, Pizzarelli, M, Pizzuti, A, Poggi, M, Posteraro, A, Privitera, C, Rampazzo, D, Ratti, C, Rettegno, S, Ricci, F, Ricci, C, Rolando, C, Rossi, S, Rovera, C, Ruggieri, R, Russo, M, Sacchi, N, Saladino, A, Sani, F, Sartori, C, Scarabeo, V, Sciacqua, A, Scillone, A, Scopelliti, P, Scorza, A, Scozzafava, A, Serafini, F, Serra, W, Severino, S, Simeone, B, Sirico, D, Solari, M, Spadaro, G, Stefani, L, Strangio, A, Surace, F, Tamborini, G, Tarquinio, N, Tassone, E, Tavarozzi, I, Tchana, B, Tedesco, G, Tinto, M, Torzillo, D, Totaro, A, Triolo, O, Troisi, F, Tusa, M, Vancheri, F, Varasano, V, Venezia, A, Vermi, A, Villari, B, Zampi, G, Zannoni, J, Zito, C, Zugaro, A, Di Bella, G, Carerj, S, Ciampi Q., Pepi M., Antonini-Canterin F., Barbieri A., Barchitta A., Faganello G., Miceli S., Parato V. M., Tota A., Trocino G., Abbate M., Accadia M., Alemanni R., Angelini A., Anglano F., Anselmi M., Aquila I., Aramu S., Avogadri E., Azzaro G., Badano L., Balducci A., Ballocca F., Barbarossa A., Barbati G., Barletta V., Barone D., Becherini F., Benfari G., Beraldi M., Bergandi G., Bilardo G., Binno S. M., Bolognesi M., Bongiovi S., Bragato R. M., Braggion G., Brancaleoni R., Bursi F., Dessalvi C. C., Cameli M., Canu A., Capitelli M., Capra A. C. M., Carbonara R., Carbone M., Carbonella M., Carrabba N., Casavecchia G., Casula M., Chesi E., Cicco S., Citro R., Cocchia R., Colombo B. M., Colonna P., Conte M., Corrado G., Cortesi P., Cortigiani L., Costantino M. F., Cozza F., Cucchini U., D'Angelo M., Ros S. D., D'Andrea F., D'Andrea A., D'Auria F., De Caridi G., De Feo S., De Matteis G. M., De Vecchi S., Del Giudice C., Dell'Angela L., Delli Paoli L., Dentamaro I., Destefanis P., Di Fulvio M., Di Gaetano R., Di Giannuario G., Di Gioia A., Di Martino L. F. M., Di Muro C., Di Nora C., Di Salvo G., Dodi C., Dogliani S., Donati F., Dottori M., Epifani G., Fabiani I., Ferrara F., Ferrara L., Ferrua S., Filice G., Fiorino M., Forno D., Garini A., Giarratana G. A., Gigantino G., Giorgi M., Giubertoni E., Greco C. A., Grigolato M., Marra W. G., Holzl A., Iaiza A., Iannaccone A., Ilardi F., Imbalzano E., Inciardi R., Inserra C. A., Iori E., Izzo A., La Rosa G., Labanti G., Lanzone A. M., Lanzoni L., Lapetina O., Leiballi E., Librera M., Lo Conte C., Lo Monaco M., Lombardo A., Luciani M., Lusardi P., Magnante A., Malagoli A., Malatesta G., Mancusi C., Manes M. T., Manganelli F., Mantovani F., Manuppelli V., Marchese V., Marinacci L., Mattioli R., Maurizio C., Mazza G. A., Mazza S., Melis M., Meloni G., Merli E., Milan A., Minardi G., Monaco A., Monte I., Montresor G., Moreo A., Mori F., Morini S., Moro C., Morrone D., Negri F., Nipote C., Nisi F., Nocco S., Novello L., Nunziata L., Perini A. P., Parodi A., Pasanisi E. M., Pastorini G., Pavasini R., Pavoni D., Pedone C., Pelliccia F., Pelliciari G., Pelloni E., Pergola V., Perillo G., Petruccelli E., Pezzullo C., Piacentini G., Picardi E., Pinna G., Pizzarelli M., Pizzuti A., Poggi M. M., Posteraro A., Privitera C., Rampazzo D., Ratti C., Rettegno S., Ricci F., Ricci C., Rolando C., Rossi S., Rovera C., Ruggieri R., Russo M. G., Sacchi N., Saladino A., Sani F., Sartori C., Scarabeo V., Sciacqua A., Scillone A., Scopelliti P. A., Scorza A., Scozzafava A., Serafini F., Serra W., Severino S., Simeone B., Sirico D., Solari M., Spadaro G. L., Stefani L., Strangio A., Surace F. C., Tamborini G., Tarquinio N., Tassone E. J., Tavarozzi I., Tchana B., Tedesco G., Tinto M., Torzillo D., Totaro A., Triolo O. F., Troisi F., Tusa M., Vancheri F., Varasano V., Venezia A., Vermi A. C., Villari B., Zampi G., Zannoni J., Zito C., Zugaro A., Di Bella G., and Carerj S.

Abstract

Background: The Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand better how different echocardiographic modalities are used and accessed in Italy. Methods: We analyzed echocardiography laboratory activities over a month (November 2022). Data were retrieved via an electronic survey based on a structured questionnaire, uploaded on the SIECVI website. Results: Data were obtained from 228 echocardiographic laboratories: 112 centers (49%) in the northern, 43 centers (19%) in the central, and 73 (32%) in the southern regions. During the month of observation, we collected 101,050 transthoracic echocardiography (TTE) examinations performed in all centers. As concern other modalities there were performed 5497 transesophageal echocardiography (TEE) examinations in 161/228 centers (71%); 4057 stress echocardiography (SE) examinations in 179/228 centers (79%); and examinations with ultrasound contrast agents (UCAs) in 151/228 centers (66%). We did not find significant regional variations between the different modalities. The usage of picture archiving and communication system (PACS) was significantly higher in the northern (84%) versus central (49%) and southern (45%) centers (P < 0.001). Lung ultrasound (LUS) was performed in 154 centers (66%), without difference between cardiology and noncardiology centers. The evaluation of left ventricular (LV) ejection fraction was evaluated mainly using the qualitative method in 223 centers (94%), occasionally with the Simpson method in 193 centers (85%), and with selective use of the three-dimensional (3D) method in only 23 centers (10%). 3D TTE was present in 137 centers (70%), and 3D TEE in all centers where TEE was done (71%). The assessment of LV diastolic function was done routinely in 80% of the centers. Right ventricular function was evaluated using tricuspid annular plane systolic excursion in all centers, using tricuspid valve annular systolic velocity by tissue

Published
2023

2. Prognostic role of global work efficiency in patients undergoing transcatheter aortic valve implantation

Author

Ilardi, F, primary, Manzo, R, additional, Franzone, A, additional, Angellotti, D, additional, Avvedimento, M, additional, Iapicca, C, additional, Manzi, L, additional, Verde, N, additional, Simonetti, F, additional, Castiello, D, additional, Leone, A, additional, Mariani, A, additional, Piccolo, R, additional, Cirillo, P, additional, and Esposito, G, additional

Published
2022
Full Text
View/download PDF

3. List of Contributors

Author

Abellás-Sequeiros, R.A., primary, Alcidi, G., additional, Alonso Salinas, G.L., additional, Arpino, G., additional, Ayach, B., additional, Boni, R., additional, Bours, V., additional, Brown, J., additional, Bucciarelli-Ducci, C., additional, Cardinale, D., additional, Coppola, C., additional, Cosyns, B., additional, Dulgheru, R., additional, Edvardsen, T., additional, Erba, P.A., additional, Freres, P., additional, Galderisi, M., additional, González-Juanatey, J.R., additional, Hinojar, R., additional, Ilardi, F., additional, Jerusalem, G., additional, Kerkhove, D., additional, Lancellotti, P., additional, López Fernández, T., additional, López López, A., additional, López Sendón, J., additional, Manrique, C.R., additional, Maurea, N., additional, Monagham, M.J., additional, Moonen, M., additional, Oury, C., additional, Paciolla, I., additional, Plana, J.C., additional, Ramos, J., additional, Rienzo, A., additional, Rigo, F., additional, Rodríguez Muñoz, D., additional, Sánchez, V., additional, Santoro, C., additional, Scherrer-Crosbie, M., additional, Sicari, R., additional, Sollini, M., additional, Sorrentino, R., additional, Tiwari, N., additional, and Zamorano Gómez, J.L., additional

Published
2017
Full Text
View/download PDF

5. Echocardiographic reference ranges for normal left atrial function parameters: Results from the EACVI NORRE study

Author

Sugimoto, T, Robinet, S, Dulgheru, R, Bernard, A, Ilardi, F, Contu, L, Addetia, K, Caballero, L, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Go, Y, Marchetta, S, Nchimi, A, Rosca, M, Calin, A, Moonen, M, Cimino, S, Magne, J, Cosyns, B, Galli, E, Donal, E, Habib, G, Esposito, R, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Sugimoto T., Robinet S., Dulgheru R., Bernard A., Ilardi F., Contu L., Addetia K., Caballero L., Kacharava G., Athanassopoulos G. D., Barone D., Baroni M., Cardim N., Hagendorff A., Hristova K., Lopez T., De La Morena G., Popescu B. A., Penicka M., Ozyigit T., Rodrigo Carbonero J. D., Van De Veire N., Von Bardeleben R. S., Vinereanu D., Zamorano J. L., Go Y. Y., Marchetta S., Nchimi A., Rosca M., Calin A., Moonen M., Cimino S., Magne J., Cosyns B., Galli E., Donal E., Habib G., Esposito R., Galderisi M., Badano L., Lang R. M., Lancellotti P., Sugimoto, T, Robinet, S, Dulgheru, R, Bernard, A, Ilardi, F, Contu, L, Addetia, K, Caballero, L, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Go, Y, Marchetta, S, Nchimi, A, Rosca, M, Calin, A, Moonen, M, Cimino, S, Magne, J, Cosyns, B, Galli, E, Donal, E, Habib, G, Esposito, R, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Sugimoto T., Robinet S., Dulgheru R., Bernard A., Ilardi F., Contu L., Addetia K., Caballero L., Kacharava G., Athanassopoulos G. D., Barone D., Baroni M., Cardim N., Hagendorff A., Hristova K., Lopez T., De La Morena G., Popescu B. A., Penicka M., Ozyigit T., Rodrigo Carbonero J. D., Van De Veire N., Von Bardeleben R. S., Vinereanu D., Zamorano J. L., Go Y. Y., Marchetta S., Nchimi A., Rosca M., Calin A., Moonen M., Cimino S., Magne J., Cosyns B., Galli E., Donal E., Habib G., Esposito R., Galderisi M., Badano L., Lang R. M., and Lancellotti P.

Abstract

Aims To obtain the normal ranges for echocardiographic measurements of left atrial (LA) function from a large group of healthy volunteers accounting for age and gender. Methods and results A total of 371 (median age 45 years) healthy subjects were enrolled at 22 collaborating institutions collaborating in the Normal Reference Ranges for Echocardiography (NORRE) study of the European Association of Cardiovascular Imaging (EACVI). Left atrial data sets were analysed with a vendor-independent software (VIS) package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire data sets. The lowest expected values of LA function were 26.1%, 48.7%, and 41.4% for left atrial strain (LAS), 2D left atrial emptying fraction (LAEF), and 3D LAEF (reservoir function); 7.7%, 24.2%, and â '0.53/s for LAS-Active, LAEF-Active, and LA strain rate during LA contraction (SRa) (pump function) and 12.0% and 21.6% for LAS-passive and LAEF-passive (conduit function). Left atrial reservoir and conduit function were decreased with age while pump function was increased. All indices of reservoir function and all LA strains had no difference in both gender and vendor. However, inter-vendor differences were observed in LA SRa despite the use of VIS. Conclusion The NORRE study provides contemporary, applicable echocardiographic reference ranges for LA function. Our data highlight the importance of age-specific reference values for LA functions.

Published
2018

6. Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

Author

Cameli, M, Miglioranza, M, Magne, J, Mandoli, G, Benfari, G, Ancona, R, Sibilio, G, Reskovic Luksic, V, Dejan, D, Griseli, L, Van De Heyning, C, Mortelmans, P, Michalski, B, Kupczynska, K, Di Giannuario, G, Devito, F, Dulgheru, R, Ilardi, F, Salustri, A, Abushahba, G, Morrone, D, Fabiani, I, Penicka, M, Katbeh, A, Sammarco, G, Esposito, R, Santoro, C, Pastore, M, Comenale Pinto, S, Kalinin, A, Pičkure, Ž, Ažman Juvan, K, Zupan Mežnar, A, Coisne, A, Coppin, A, Opris, M, Nistor, D, Paakkanen, R, Biering-Sørensen, T, Olsen, F, Lapinskas, T, Vaškelyté, J, Galian-Gay, L, Casas, G, Motoc, A, Papadopoulos, C, Loizos, S, Ágoston, G, Szabó, I, Hristova, K, Tsonev, S, Galli, E, Vinereanu, D, Mihaila Baldea, S, Muraru, D, Mondillo, S, Donal, E, Galderisi, M, Cosyns, B, Edvardsen, T, Popescu, B, Cameli, Matteo, Miglioranza, Marcelo Haertel, Magne, Julien, Mandoli, Giulia Elena, Benfari, Giovanni, Ancona, Roberta, Sibilio, Gerolamo, Reskovic Luksic, Vlatka, Dejan, Dosen, Griseli, Leonardo, Van De Heyning, Caroline M, Mortelmans, Philippe, Michalski, Blazej, Kupczynska, Karolina, Di Giannuario, Giovanna, Devito, Fiorella, Dulgheru, Raluca, Ilardi, Federica, Salustri, Alessandro, Abushahba, Galal, Morrone, Doralisa, Fabiani, Iacopo, Penicka, Martin, Katbeh, Asim, Sammarco, Giuseppe, Esposito, Roberta, Santoro, Ciro, Pastore, Maria Concetta, Comenale Pinto, Salvatore, Kalinin, Artem, Pičkure, Žanna, Ažman Juvan, Katja, Zupan Mežnar, Anja, Coisne, Augustine, Coppin, Amandine, Opris, Mihaela Maria, Nistor, Dan Octavian, Paakkanen, Riitta, Biering-Sørensen, Tor, Olsen, Flemming Javier, Lapinskas, Tomas, Vaškelyté, Jolanta Justina, Galian-Gay, Laura, Casas, Guillem, Motoc, Andreea Iulia, Papadopoulos, Constantinos Hristou, Loizos, Savvas, Ágoston, Gergely, Szabó, Istvan, Hristova, Krasimira, Tsonev, Svetlin Netkov, Galli, Elena, Vinereanu, Dragos, Mihaila Baldea, Sorina, Muraru, Denisa, Mondillo, Sergio, Donal, Erwan, Galderisi, Maurizio, Cosyns, Bernard, Edvardsen, Thor, Popescu, Bogdan A, Cameli, M, Miglioranza, M, Magne, J, Mandoli, G, Benfari, G, Ancona, R, Sibilio, G, Reskovic Luksic, V, Dejan, D, Griseli, L, Van De Heyning, C, Mortelmans, P, Michalski, B, Kupczynska, K, Di Giannuario, G, Devito, F, Dulgheru, R, Ilardi, F, Salustri, A, Abushahba, G, Morrone, D, Fabiani, I, Penicka, M, Katbeh, A, Sammarco, G, Esposito, R, Santoro, C, Pastore, M, Comenale Pinto, S, Kalinin, A, Pičkure, Ž, Ažman Juvan, K, Zupan Mežnar, A, Coisne, A, Coppin, A, Opris, M, Nistor, D, Paakkanen, R, Biering-Sørensen, T, Olsen, F, Lapinskas, T, Vaškelyté, J, Galian-Gay, L, Casas, G, Motoc, A, Papadopoulos, C, Loizos, S, Ágoston, G, Szabó, I, Hristova, K, Tsonev, S, Galli, E, Vinereanu, D, Mihaila Baldea, S, Muraru, D, Mondillo, S, Donal, E, Galderisi, M, Cosyns, B, Edvardsen, T, Popescu, B, Cameli, Matteo, Miglioranza, Marcelo Haertel, Magne, Julien, Mandoli, Giulia Elena, Benfari, Giovanni, Ancona, Roberta, Sibilio, Gerolamo, Reskovic Luksic, Vlatka, Dejan, Dosen, Griseli, Leonardo, Van De Heyning, Caroline M, Mortelmans, Philippe, Michalski, Blazej, Kupczynska, Karolina, Di Giannuario, Giovanna, Devito, Fiorella, Dulgheru, Raluca, Ilardi, Federica, Salustri, Alessandro, Abushahba, Galal, Morrone, Doralisa, Fabiani, Iacopo, Penicka, Martin, Katbeh, Asim, Sammarco, Giuseppe, Esposito, Roberta, Santoro, Ciro, Pastore, Maria Concetta, Comenale Pinto, Salvatore, Kalinin, Artem, Pičkure, Žanna, Ažman Juvan, Katja, Zupan Mežnar, Anja, Coisne, Augustine, Coppin, Amandine, Opris, Mihaela Maria, Nistor, Dan Octavian, Paakkanen, Riitta, Biering-Sørensen, Tor, Olsen, Flemming Javier, Lapinskas, Tomas, Vaškelyté, Jolanta Justina, Galian-Gay, Laura, Casas, Guillem, Motoc, Andreea Iulia, Papadopoulos, Constantinos Hristou, Loizos, Savvas, Ágoston, Gergely, Szabó, Istvan, Hristova, Krasimira, Tsonev, Svetlin Netkov, Galli, Elena, Vinereanu, Dragos, Mihaila Baldea, Sorina, Muraru, Denisa, Mondillo, Sergio, Donal, Erwan, Galderisi, Maurizio, Cosyns, Bernard, Edvardsen, Thor, and Popescu, Bogdan A

Abstract

Two methods are currently available for left atrial (LA) strain measurement by speckle tracking echocardiography, with two different reference timings for starting the analysis: QRS (QRS-LASr) and P wave (P-LASr). The aim of MASCOT HIT study was to define which of the two was more reproducible, more feasible, and less time consuming. In 26 expert centers, LA strain was analyzed by two different echocardiographers (young vs senior) in a blinded fashion. The study population included: healthy subjects, patients with arterial hypertension or aortic stenosis (LA pressure overload, group 2) and patients with mitral regurgitation or heart failure (LA volume-pressure overload, group 3). Difference between the inter-correlation coefficient (ICC) by the two echocardiographers using the two techniques, feasibility and analysis time of both methods were analyzed. A total of 938 subjects were included: 309 controls, 333 patients in group 2, and 296 patients in group 3. The ICC was comparable between QRS-LASr (0.93) and P-LASr (0.90). The young echocardiographers calculated QRS-LASr in 90% of cases, the expert ones in 95%. The feasibility of P-LASr was 85% by young echocardiographers and 88% by senior ones. QRS-LASr young median time was 110 s (interquartile range, IR, 78-149) vs senior 110 s (IR 78-155); for P-LASr, 120 s (IR 80-165) and 120 s (IR 90-161), respectively. LA strain was feasible in the majority of patients with similar reproducibility for both methods. QRS complex guaranteed a slightly higher feasibility and a lower time wasting compared to the use of P wave as the reference.

Published
2020

7. Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study

Author

Tsugu, T, Postolache, A, Dulgheru, R, Sugimoto, T, Tridetti, J, Nguyen Trung, M, Piette, C, Moonen, M, Manganaro, R, Ilardi, F, Chitroceanu, A, Sperlongano, S, Go, Y, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, de la Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, van de Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Rosca, M, Calin, A, Magne, J, Cosyns, B, Galli, E, Donal, E, Santoro, C, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Tsugu, Toshimitsu, Postolache, Adriana, Dulgheru, Raluca, Sugimoto, Tadafumi, Tridetti, Julien, Nguyen Trung, Mai-Linh, Piette, Caroline, Moonen, Marie, Manganaro, Roberta, Ilardi, Federica, Chitroceanu, Alexandra Maria, Sperlongano, Simona, Go, Yun Yun, Kacharava, George, Athanassopoulos, George D, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andreas, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Dragos, Zamorano, Jose Luis, Rosca, Monica, Calin, Andreea, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi, Lang, Roberto M, Lancellotti, Patrizio, Tsugu, T, Postolache, A, Dulgheru, R, Sugimoto, T, Tridetti, J, Nguyen Trung, M, Piette, C, Moonen, M, Manganaro, R, Ilardi, F, Chitroceanu, A, Sperlongano, S, Go, Y, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, de la Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, van de Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Rosca, M, Calin, A, Magne, J, Cosyns, B, Galli, E, Donal, E, Santoro, C, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Tsugu, Toshimitsu, Postolache, Adriana, Dulgheru, Raluca, Sugimoto, Tadafumi, Tridetti, Julien, Nguyen Trung, Mai-Linh, Piette, Caroline, Moonen, Marie, Manganaro, Roberta, Ilardi, Federica, Chitroceanu, Alexandra Maria, Sperlongano, Simona, Go, Yun Yun, Kacharava, George, Athanassopoulos, George D, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andreas, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Dragos, Zamorano, Jose Luis, Rosca, Monica, Calin, Andreea, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi, Lang, Roberto M, and Lancellotti, Patrizio

Abstract

Aims : To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages. Methods and results : A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were -15.0% in men and -15.6% in women for epicardial strain, -16.8% and -17.7% for mid-myocardial strain, and -18.7% and -19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = -0.20, P = 0.007, mid-myocardial; r = -0.21, P = 0.006, endocardial; r = -0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1). Conclusion : The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.

Published
2020

8. Correlation between non-invasive myocardial work indices and main parameters of systolic and diastolic function: results from the EACVI NORRE study

Author

Manganaro, R, Marchetta, S, Dulgheru, R, Sugimoto, T, Tsugu, T, Ilardi, F, Cicenia, M, Ancion, A, Postolache, A, Martinez, C, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, de la Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, van de Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Rosca, M, Calin, A, Moonen, M, Magne, J, Cosyns, B, Galli, E, Donal, E, Carerj, S, Zito, C, Santoro, C, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Manganaro, Roberta, Marchetta, Stella, Dulgheru, Raluca, Sugimoto, Tadafumi, Tsugu, Toshimitsu, Ilardi, Federica, Cicenia, Marianna, Ancion, Arnaud, Postolache, Adriana, Martinez, Christophe, Kacharava, George, Athanassopoulos, George D, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andreas, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Dragos, Zamorano, Jose Luis, Rosca, Monica, Calin, Andreea, Moonen, Marie, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Carerj, Scipione, Zito, Concetta, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi, Lang, Roberto M, Lancellotti, Patrizio, Manganaro, R, Marchetta, S, Dulgheru, R, Sugimoto, T, Tsugu, T, Ilardi, F, Cicenia, M, Ancion, A, Postolache, A, Martinez, C, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, de la Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, van de Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Rosca, M, Calin, A, Moonen, M, Magne, J, Cosyns, B, Galli, E, Donal, E, Carerj, S, Zito, C, Santoro, C, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Manganaro, Roberta, Marchetta, Stella, Dulgheru, Raluca, Sugimoto, Tadafumi, Tsugu, Toshimitsu, Ilardi, Federica, Cicenia, Marianna, Ancion, Arnaud, Postolache, Adriana, Martinez, Christophe, Kacharava, George, Athanassopoulos, George D, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andreas, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Dragos, Zamorano, Jose Luis, Rosca, Monica, Calin, Andreea, Moonen, Marie, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Carerj, Scipione, Zito, Concetta, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi, Lang, Roberto M, and Lancellotti, Patrizio

Abstract

AIMS: The present study sought to evaluate the correlation between indices of non-invasive myocardial work (MW) and left ventricle (LV) size, traditional and advanced parameters of LV systolic and diastolic function by 2D echocardiography (2DE). METHODS AND RESULTS: A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from LV pressure-strain loops using custom software. Peak LV pressure was estimated non-invasively from brachial artery cuff pressure. LV size, parameters of systolic and diastolic function and ventricular-arterial coupling were measured by echocardiography. As advanced indices of myocardial performance, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were obtained. On multivariable analysis, GWI was significantly correlated with GLS (standardized beta-coefficient = -0.23, P < 0.001), ejection fraction (EF) (standardized beta-coefficient = 0.15, P = 0.02), systolic blood pressure (SBP) (standardized beta-coefficient = 0.56, P < 0.001) and GRS (standardized beta-coefficient = 0.19, P = 0.004), while GCW was correlated with GLS (standardized beta-coefficient = -0.55, P < 0.001), SBP (standardized beta-coefficient = 0.71, P < 0.001), GRS (standardized beta-coefficient = 0.11, P = 0.02), and GCS (standardized beta-coefficient = -0.10, P = 0.01). GWE was directly correlated with EF and inversely correlated with Tei index (standardized beta-coefficient = 0.18, P = 0.009 and standardized beta-coefficient = -0.20, P = 0.004, respectively), the opposite occurred for GWW (standardized beta-coefficient =--0.14, P = 0.03 and standardized beta-coefficient = 0.17, P = 0.01, respectively). CONCLUSION: The non-invasive MW indices show a good correlati

Published
2020

12. Echocardiographic reference ranges for normal left ventricular 2D strain: Results from the EACVI NORRE study

Author

Sugimoto, T, Dulgheru, R, Bernard, A, Ilardi, F, Contu, L, Addetia, K, Caballero, L, Akhaladze, N, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, De La Morena, G, Popescu, B, Moonen, M, Penicka, M, Ozyigit, T, Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Go, Y, Rosca, M, Calin, A, Magne, J, Cosyns, B, Marchetta, S, Donal, E, Habib, G, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Sugimoto T., Dulgheru R., Bernard A., Ilardi F., Contu L., Addetia K., Caballero L., Akhaladze N., Athanassopoulos G. D., Barone D., Baroni M., Cardim N., Hagendorff A., Hristova K., Lopez T., De La Morena G., Popescu B. A., Moonen M., Penicka M., Ozyigit T., Carbonero J. D. R., Van De Veire N., Von Bardeleben R. S., Vinereanu D., Zamorano J. L., Go Y. Y., Rosca M., Calin A., Magne J., Cosyns B., Marchetta S., Donal E., Habib G., Galderisi M., Badano L., Lang R. M., Lancellotti P., Sugimoto, T, Dulgheru, R, Bernard, A, Ilardi, F, Contu, L, Addetia, K, Caballero, L, Akhaladze, N, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, De La Morena, G, Popescu, B, Moonen, M, Penicka, M, Ozyigit, T, Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Go, Y, Rosca, M, Calin, A, Magne, J, Cosyns, B, Marchetta, S, Donal, E, Habib, G, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Sugimoto T., Dulgheru R., Bernard A., Ilardi F., Contu L., Addetia K., Caballero L., Akhaladze N., Athanassopoulos G. D., Barone D., Baroni M., Cardim N., Hagendorff A., Hristova K., Lopez T., De La Morena G., Popescu B. A., Moonen M., Penicka M., Ozyigit T., Carbonero J. D. R., Van De Veire N., Von Bardeleben R. S., Vinereanu D., Zamorano J. L., Go Y. Y., Rosca M., Calin A., Magne J., Cosyns B., Marchetta S., Donal E., Habib G., Galderisi M., Badano L., Lang R. M., and Lancellotti P.

Abstract

Aims To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender Methods and results A total of 549 (mean age: 45.6 ± 13.3 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. 2DE data sets have been analysed with a vendorindependent software package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire the data sets. The lowest expected values of LV strains and twist calculated as ± 1.96 standard deviations from the mean were-16.7% in men and-17.8% in women for longitudinal strain,-22.3% and-23.6% for circumferential strain, 20.6% and 21.5% for radial strain, and 2.2 degrees and 1.9 degrees for twist, respectively. In multivariable analysis, longitudinal strain decreased with age whereas the opposite occurred with circumferential and radial strain. Male gender was associated with lower strain for longitudinal, circumferential, and radial strain. Inter-vendor differences were observed for circumferential and radial strain despite the use of vendor-independent software. Importantly, no intervendor differences were noted in longitudinal strain. Conclusion The NORRE study provides contemporary, applicable 2D echocardiographic reference ranges for LV longitudinal, radial, and circumferential strain. Our data highlight the importance of age-and gender-specific reference values for LV strain.

Published
2017

13. 3D echocardiographic reference ranges for normal left ventricular volumes and strain: Results fromthe EACVI NORRE study

Author

Bernard, A, Addetia, K, Dulgheru, R, Caballero, L, Sugimoto, T, Akhaladze, N, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Ilardi, F, Lopez, T, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Martinez, C, Magne, J, Cosyns, B, Donal, E, Habib, G, Badano, L, Lang, R, Lancellotti, P, Bernard A., Addetia K., Dulgheru R., Caballero L., Sugimoto T., Akhaladze N., Athanassopoulos G. D., Barone D., Baroni M., Cardim N., Hagendorff A., Hristova K., Ilardi F., Lopez T., De La Morena G., Popescu B. A., Penicka M., Ozyigit T., Carbonero J. D. R., Van De Veire N., Von Bardeleben R. S., Vinereanu D., Zamorano J. L., Martinez C., Magne J., Cosyns B., Donal E., Habib G., Badano L., Lang R. M., Lancellotti P., Bernard, A, Addetia, K, Dulgheru, R, Caballero, L, Sugimoto, T, Akhaladze, N, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Ilardi, F, Lopez, T, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Martinez, C, Magne, J, Cosyns, B, Donal, E, Habib, G, Badano, L, Lang, R, Lancellotti, P, Bernard A., Addetia K., Dulgheru R., Caballero L., Sugimoto T., Akhaladze N., Athanassopoulos G. D., Barone D., Baroni M., Cardim N., Hagendorff A., Hristova K., Ilardi F., Lopez T., De La Morena G., Popescu B. A., Penicka M., Ozyigit T., Carbonero J. D. R., Van De Veire N., Von Bardeleben R. S., Vinereanu D., Zamorano J. L., Martinez C., Magne J., Cosyns B., Donal E., Habib G., Badano L., Lang R. M., and Lancellotti P.

Abstract

Aim To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results A total of 440 (mean age: 45613 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets. Upper limits of LV end-diastolic and end-systolic volumes were larger in men (97 and 42 mL/m2) than in women (82 and 35 mL/m2; P<0.0001). Conversely, lower limits of LV ejection fraction were higher in women than in men (51% vs. 50%; P<0.01). Similarly, all strain components were higher in women than in men. Lower range was -18.6% in men and -19.5% in women for 3D longitudinal strain, -27.0% and -27.6% for 3D circumferential strain, -33.2% and -34.4% for 3D tangential strain and 38.8% and 40.7% for 3D radial strain, respectively. LV volumes decreased with age in both genders (P<0.0001), whereas LV ejection fraction increased with age only in men. Among 3DE LV strain components, the only one, which did not change with age was longitudinal strain. Conclusion The NORRE study provides applicable 3D echocardiographic reference ranges for LV function assessment. Our data highlight the importance of age- and gender-specific reference values for both LV volumes and strain. All rights reserved.

Published
2017

16. Rac1 modulates endothelial function and platelet aggregation in diabetes mellitus

Author

Schiattarella, G.G., Carrizzo, A., Ilardi, F., Damato, A., Ambrosio, M., Madonna, M., Trimarco, V., Marino, M., De Angelis, E., Settembrini, S., Perrino, C., Trimarco, B., Esposito, G., and Vecchione, C.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

BACKGROUND: Vascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho-related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diabetes mellitus. METHODS AND RESULTS: We used both in vitro and ex vivo approaches to test the effects of pharmacological inhibition of Rac1 during hyperglycemic condition. We evaluated the effect of NSC23766, a pharmacological inhibitor of Rac1, on vascular function in diabetic mice and platelet aggregation in diabetic subjects. We demonstrated that the administration of NSC23766 protects from hyperglycemia-induced endothelial dysfunction, restoring NO levels, and reduces oxidative stress generated by nicotinamide adenine dinucleotide phosphate oxidase. Mechanistically, we identified Rho-associated coiled-coil serine/threonine kinase-1 as a downstream target of Rac1. Moreover, we reported that during hyperglycemic conditions, human platelets showed hyperactivation of Rac1 and impaired NO release, which were both partially restored after NSC23766 treatment. Finally, we characterized the antiplatelet effect of NSC23766 during hyperglycemic conditions, demonstrating the additional role of Rac1 inhibition in reducing platelet aggregation in diabetic patients treated with common antiplatelet drugs. CONCLUSIONS: Our data suggest that the pharmacological inhibition of Rac1 could represent a novel therapeutic strategy to reduce endothelial dysfunction and platelet hyperaggregation in diabetes mellitus.

Published
2018

21. The importance of using strain derived criteria for detection of subclinical cardiotoxicity in breast cancer patients undergoing anthracycline and trastuzumab

Author

Santoro, C, Esposito, R, Schiano Lomoriello, V, Muscariello, R, Lembo, M, Ilardi, F, ARPINO, GRAZIA, DE PLACIDO, SABINO, DE SIMONE, GIOVANNI, GALDERISI, MAURIZIO, Santoro, C, Esposito, R, Schiano-Lomoriello, V, Muscariello, R, Lembo, M, Ilardi, F, Arpino, G, De Placido, S, de Simone, G, Galderisi, M, Schiano Lomoriello, V, Arpino, Grazia, DE PLACIDO, Sabino, DE SIMONE, Giovanni, and Galderisi, Maurizio

Published
2015

22. 4058Effects of selective and nonselective beta-blockers on platelet aggregation in patients with acute coronary syndrome: the PLATE-BLOCK study

Author

Ilardi, F, primary, Gargiulo, G, additional, Schiattarella, G G, additional, Giugliano, G, additional, Paolillo, R, additional, Menafra, G, additional, De Angelis, E, additional, Franzone, A, additional, Stabile, E, additional, Perrino, C, additional, Cirillo, P, additional, Morisco, C, additional, Izzo, R, additional, Trimarco, V, additional, and Esposito, G, additional

Published
2018
Full Text
View/download PDF

25. Quinacrine as a novel drug in the prevention of in-stent restenosis and thrombosis

Author

Gargiulo, G, Schiattarella, GG, Pironti, G, Di Serafino, L, Scudiero, L, Serino, F, Ilardi, F, Petrillo, G, PERRINO, CINZIA, CIRILLO, PLINIO, ESPOSITO, GIOVANNI, Gargiulo, G, Perrino, Cinzia, Schiattarella, Gg, Pironti, G, Di Serafino, L, Scudiero, L, Serino, F, Ilardi, F, Petrillo, G, Cirillo, Plinio, and Esposito, Giovanni

Published
2011

26. P1270Effects of blood pressure variability on layer-specific longitudinal strain in hypertensionP1271 Left atrial dynamics and diastolic function in hypertensive patientsP1272Echocardiographic evaluation of right ventricular function in patients with chronic obstructive pulmonary disease in comparison with healthy groupP1273The impact of preeclampsia on myocardial recovery in women with peripartum cardiomyopahty - speckle tracking studyP1274Diagnostic accuracy of bedside lung ultrasonography in emergency (BLUE) protocol in discriminating cardiovascular causes of acute dyspneaP1275Heart failure with preserved and reduced ejection fraction - the mysterious role of ghrelin in the improvement of cardiac mechanicsP1276Prolonged atrial electromechanical coupling interval in patients with vitamin d deficiencyP1277Early detection of cardiotoxicity induced by new target therapy by strain echocardiography and arterial stiffnessP1278Long term course of bicuspid aortic valve in patients with and without associated cardiac malformations. A single-centre, retrospective cohort studyP1279Left ventricular mechanics in ALCAPA patients post successful repair: really normal?P1280Next generation stress echo computerized software (SECS)P1281Non invasive hemodynamic profile of patients developing inducible ischemia at dobutamine stress echocardiography: a global longitudinal strain investigation P1282Silent myocardial ischaemia is highly prevalent in patients with chronic obstructive pulmonary disease referred for dobutamine stress echocardiographyP1283Silent chronic obstructive pulmonary disease is highly prevalent in patients referred for dobutamine stress echocardiography with shortness of breathP1284Exercise echocardiography for the prediction of mortality after coronary artery by-pass surgery.P1285Exercise echocardiography reveals higher LV myocardial performance efficiency in adolescent elite athletes compared to non-athlete controlsP1287Impact of subclinical left ventricular myocardial dysfunction on exercise capacity in young patients with type 1 diabetes mellitusP1288Mitral annular plane systolic excursion as additional evaluation for left ventricular ejection fractionP12892 dimensional global longitudinal strain and mitral annular plane systolic?excursion as additional evaluation for left ventricular ejection fractionP1290Assessment of the left atrial appendage systolic function by 3 dimensional transoesophageal echocardiographyP1291Functional anatomy of mitral valve in obstructive hypertrophic cardiomyopathy patientsP1292Right ventricle deformation indices discriminate better than left ventricle deformation indices and fractional shortening between healthy and hypothermia treated asphyxiated neonatesP1293Determinants of myocardial strain in chronic myocardial infarction

Author

Tsai, W-C, primary, Chamodraka, E., primary, Behzadnia, N., primary, Hristova, K., primary, Ledakowicz-Polak, A., primary, Kupczynska, K., primary, Hacioglu, Y., primary, Novo, G., primary, Lamy, J., primary, Di Salvo, G., primary, Ciampi, Q., primary, Santoro, C., primary, O'driscoll, J., primary, Peteiro Vazquez, JC., primary, Pieles, GE., primary, Ruisanchez Villar, C., primary, Cho, EJ., primary, Garcia Martin, A., primary, Pavlyukova, EN., primary, Nestaas, E., primary, Ballo, H., primary, Lee, W-H, additional, Liu, Y-W, additional, Kallistratos, E., additional, Athanasiou, D., additional, Giannitsi, S., additional, Manetos, C., additional, Athanasiadis, G., additional, Asonitis, M., additional, Kouremenos, N., additional, Tsoukas, A., additional, Manolis, A., additional, Asadpour-Piranfar, M., additional, Sharif-Kashani, BABAK, additional, Ameli, N., additional, Marinov, R., additional, Stamenov, G., additional, Chacheva, K., additional, Michova, M., additional, Persenska, S., additional, Dimova, N., additional, Racheva, A., additional, Krauza, G., additional, Stokfisz, K., additional, Zielinska, M., additional, Michalski, BW., additional, Trzcinski, P., additional, Miskowiec, D., additional, Peczek, L., additional, Lipiec, P., additional, Kasprzak, JD., additional, Karabag, T., additional, Piskinpasa, ME., additional, Sametoglu, F., additional, Yuksel, Y., additional, Di Lisi, D., additional, Meschisi, M., additional, Cosentino, F., additional, Bonomo, V., additional, Mazzola, G., additional, D'angelo, F., additional, Vella, I., additional, Bronte, E., additional, Badalamenti, G., additional, Russo, A., additional, Chopard, R., additional, Ecarnot, F., additional, Tchaoussoff, C., additional, Schiele, F., additional, Bernard, YF., additional, Al Qweai, N., additional, Issa, Z., additional, Muhanna, N., additional, Habdan, M., additional, Pergola, V., additional, Fadel, B., additional, Siblini, G., additional, Paterni, M., additional, Cortigiani, L., additional, Citro, R., additional, Sicari, R., additional, Galderisi, M., additional, Bossone, E., additional, Colonna, P., additional, Picano, E., additional, Ilardi, F., additional, Schiano-Lomoriello, V., additional, Esposito, R., additional, Cocozza, S., additional, Lo Iudice, F., additional, Lembo, M., additional, Trimarco, B., additional, Madden, B., additional, Giannoglou, D., additional, Peresso, V., additional, Marciniak, A., additional, Nazir, S., additional, Sharma, R., additional, Bouzas-Mosquera, A., additional, Pardo, P., additional, Broullon-Molanes, F., additional, Vazquez-Rodriguez, JM., additional, Luszczak, J., additional, Gowing, L., additional, Stuart, AG., additional, Williams, CA., additional, Gonzalez Vilchez, FJ., additional, Piedra Leon, M., additional, Marigomez Estrada, M., additional, Pesquera Gonzalez, C., additional, Ruano Calvo, J., additional, Zarauza Navarro, J., additional, Martin Duran, R., additional, Amado Senaris, JA., additional, Jeong, MY., additional, Kim, HJ., additional, Kwak, MH., additional, Moya Mur, JL., additional, Fernandez-Golfin, C., additional, Casas Rojo, E., additional, Del Val Martin, D., additional, Pardo Sanz, A., additional, Gonzalez Gomez, A., additional, Hinojar, R., additional, Berlot, B., additional, Zamorano, JL., additional, Evtushenko, AV., additional, Smushlyaev, KA., additional, Karpov, RS., additional, Stoylen, A., additional, Fugelseth, D., additional, Tarkia, M., additional, Haavisto, M., additional, Stark, C., additional, Vahasilta, T., additional, Strandberg, M., additional, Saukko, P., additional, Savunen, T., additional, Knuuti, J., additional, and Saraste, A., additional

Published
2016
Full Text
View/download PDF

27. Clinical Cases: Ischaemic heart disease899Asymptomatic very late presentation of ALCAPA900Usefulness of 3-dimensional contrast echocardiography in the diagnosis of a left ventricular pseudoaneurysm after acute myocardial infarction901Peri-procedural jailing of septal perforator branch retrospectively identified using speckle tracking echocardiography902Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA)903Coronary artery compression by aneurysmal pulmonary artery904A rare complication of myocardial infarction: pseudoaneurysm leading to ischaemic VSD905Single coronary ostium from the right aortic sinus of valsalva906Incremental value of regional longitudinal strain upon visual assessment for detection of ischemia during dobutamine stress echocardiography907One serious complication after myocardial infarction, isn't that enough?

Author

Cambronero Cortinas, E., primary, Marini, C., primary, Sorrentino, R., primary, Hassan, Y., primary, Badea, RG., primary, Heseltine, TD., primary, Laymouna, R., primary, Santoro, C., primary, Sawicka, K., primary, Gonzalez Garcia, AE., additional, Bret Zurita, M., additional, Garcia Hamilton, D., additional, Corbi Pascual, MJ., additional, Ruiz Cantador, J., additional, Oliver Ruiz, JM., additional, Ancona, F., additional, Stella, S., additional, Rosa, I., additional, Spartera, M., additional, Melisurgo, G., additional, Pappalardo, F., additional, Margonato, A., additional, Agricola, E., additional, Lo Iudice, F., additional, Niglio, T., additional, Stabile, E., additional, Galderisi, M., additional, Trimarco, B., additional, Elsharkawy, E., additional, Laymouna, R., additional, Elgowelly, M., additional, Almaghraby, A., additional, Enache, R., additional, Serban, M., additional, Gherasim, D., additional, Platon, P., additional, Ginghina, C., additional, Lima, E., additional, Cino-Polla, JM., additional, Hassan, Y., additional, Ilardi, F., additional, Lembo, M., additional, Cirillo, P., additional, Esposito, G., additional, Prasal, M., additional, Tomaszewski, M., additional, Wojtkowska, A., additional, and Tomaszewski, A., additional

Published
2016
Full Text
View/download PDF

28. Endovascular treatment of carotid artery stenosis: evidences from randomized controlled trials and actual indications

Author

Ilardi, F., Magliulo, F., Gargiulo, G., Schiattarella, G.G., Carotenuto, G., Serino, F., Ferrone, M., Visco, E., Scudiero, F., Carbone, A., Perrino, C., Trimarco, B., and Esposito, G.

Subjects
Cardiovascular and Metabolic Diseases, cardiovascular diseases
Abstract

Atherosclerotic stenosis of common and internal carotid arteries is a well-recognized risk factor for ischemic stroke, and revascularization has been proven to be the main tool of prevention, particularly for patients with stenosis-related symptoms. While for many years surgical carotid endarterectomy (CEA) has been considered the gold-standard strategy to restore vascular patency, recently the endovascular treatment through percutaneous angioplasty and stent implantation (CAS) has become a valid alternative. In the last years, interesting data about the comparison of these strategies have emerged. CAS seems to cause more peri-procedural strokes, but may also avoid many adverse events related to surgery and general anaesthesia, including peri-procedural myocardial infarction. For these reasons, it was initially considered a second-choice strategy to be adopted in patients for whom surgery was contraindicated. However, more recent trials have shown that CAS might be considered an effective alternative to CEA. Moreover, the rapid evolution of CAS technique and materials suggests its potential to improve outcome and possible superiority compared to CEA in the next future. Purpose of this review is to discuss the most recent clinical evidences concerning the treatment of carotid artery stenosis, with a special focus on the endovascular treatment.

Published
2011

29. Moderated Posters session: diastolic function in clinical perspectiveP1260Coronary flow reserve in patients with chest pain but without significant coronary stenosis: the role of hypertensionP1261Diastolic bicycle exercise: normal reference values and determinantsP1262Prediction of left ventricular diastolic dysfunction in breast cancer patients after chemotherapyP1263Impaired diastolic recovery is associated with adverse events in the patients with hypertensive heart failureP1264Diastolic strain parameters in hypertensive heart disease: Insights from a speckle tracking imagingP1265Standard echocardiographic parameters to assess right ventricular diastolic function does not detect increased end diastolic right ventricular pressure in pulmonary vascular diseaseP1266In heart failure with preserved ejection fraction carotid arterial stiffness is increased and may contribute to reduced functional reserveP1267Study of left atrial function by speckle tracking in young Egyptian females with unexplained dyspnea; pilot reportP1268stress effect on diastolic functionP1269Diastolic function and adjusted diastolic index in apparently healthy obese patients

Author

Fang, F, primary, Santoro, C, primary, Hristova, K, primary, Yoon, HJ, primary, Abid, L, primary, Poller, A, primary, Erdei, T, primary, Ahmed, T, primary, Geraeli, B, primary, Gascuena, R, primary, Li, YJ, additional, Yang, J, additional, Bartel, T, additional, Erbel, R, additional, Ya, Y, additional, Yu, CM, additional, Schiano Lomoriello, V, additional, Esposito, R, additional, Casaretti, L, additional, Ilardi, F, additional, Fazio, V, additional, De Simone, G, additional, Trimarco, B, additional, Galderisi, M, additional, Hristova, K, additional, Marinov, R, additional, Katova, TZ, additional, Kostova, V, additional, Simova, I, additional, Kim, KH, additional, Cho, JY, additional, Park, JC, additional, Ben Kahla, S, additional, Bech-Hanssen, O, additional, Sunderji, I, additional, Sanchez-Martinez, S, additional, Edwards, J, additional, Braim, D, additional, Price, C, additional, Bijnens, B, additional, Fraser, AG, additional, Mohmed, LA, additional, Abd-Elhady, B, additional, Abdellaha, M, additional, Mazen, A, additional, Sattarzadeh Badkoubeh, R, additional, Hassanbeigy, HR, additional, Tavoosi, A, additional, Larti, F, additional, Saberi, K, additional, Rubio, L, additional, Terol, B, additional, and Rico, C, additional

Published
2015
Full Text
View/download PDF

30. Young Investigator Award session – Clinical Science442Left bundle branch block and coronary artery disease in coronary ct angiography443Focal myocardial fibrosis and abnormal left ventricular strain in patients with sarcoidosis without clinical evidence of cardiac disease444Arhgap24, a first gene for fibro elastic deficiency mitral valve prolapse? A phenotypic study445Advantage of using ASE/EACVI criteria for detection of subclinical cardiotoxicity in breast cancer patients undergoing anthracycline and trastuzumab therapy

Author

Clerc, O F, primary, Lima Da Silva, G, primary, Jobbe Duval, A, primary, Santoro, C, primary, Possner, M, additional, Liga, R, additional, Fuchs, T A, additional, Dougoud, S, additional, Stehli, J, additional, Vontobel, J, additional, Mikulicic, F, additional, Kaufmann, P A, additional, Gaemperli, O, additional, Almeida, A M G, additional, David, C, additional, Francisco, AR, additional, Guimaraes, T, additional, Placido, R, additional, Menezes, M, additional, Pinto, FJ, additional, Rimbert, A, additional, Cueff, C, additional, Lecointe, S, additional, Hagege, AA, additional, Levine, R, additional, Merot, J, additional, Le Marec, H, additional, Schott, JJ, additional, Le Tourneau, T, additional, Lembo, M, additional, Esposito, R, additional, Cocozza, S, additional, Ilardi, F, additional, Arpino, G, additional, De Placido, S, additional, De Simone, G, additional, Trimarco, B, additional, and Galderisi, M, additional

Published
2015
Full Text
View/download PDF

31. Statins and the elderly: Recent evidence and current indications

Author

Schiattarella, G. G., Perrino, C., Magliulo, F., Ilardi, F., Serino, F., Trimarco, V., Izzo, R., Amato, B., Terranova, C., Cardin, F., Militello, C., Leosco, D., Trimarco, B., Giovanni ESPOSITO, Schiattarella, G. G., Perrino, Cinzia, Magliulo, F., Ilardo, F., Serino, F., Trimarco, Valentina, Izzo, Raffaele, Amato, Bruno, Terranova, C., Cardin, F., Militello, C., Leosco, Dario, Trimarco, Bruno, and Esposito, Giovanni

32. Low-dose quinacrine reduces vascular restenosis without affecting re-endothelialization

Author

Perrino, C., Gargiulo, G., Schiattarella, G. G., Di Serafino, L., Gianluigi Pironti, Magliulo, F., Ilardi, F., Serino, F., Bottino, R., Laurino, F. I., Ferrone, M., Bevilacqua, M., Cirillo, P., Indolfi, C., Trimarco, B., Esposito, G., Perrino, Cinzia, Gargiulo, Giuseppe, Schiattarella, Gabriele Giacomo, Di Serafino, Luigi, Pironti, Gianluigi, Magliulo, Fabio, Ilardi, Federica, Serino, Federica, Bottino, Roberta, Laurino, FLORA ILARIA, Ferrone, Marco, Bevilacqua, Michele, Cirillo, Plinio, Indolfi, Ciro, Trimarco, Bruno, and Esposito, Giovanni

Subjects
Physiology, Physiology (medical), Thrombosi, Smooth muscle cell proliferation, Drug-eluting stent, Cardiology and Cardiovascular Medicine, Re-endothelialization, In-stent restenosi
Abstract

Background: Coronary drug-eluting stents have significantly reduced the rate of in-stent restenosis, but the rate of in-stent thrombosis seems increased. In this study, we tested whether Quinacrine (Q) might reduce smooth muscle cells (SMC) proliferation while exerting minor effects on endothelial cells proliferation (EC) or thrombosis. Methods: Human SMC and EC were treated with increasing concentrations of Q, and the effects on apoptosis or cell proliferation were tested. Next, we evaluated Q effects on tissue factor (TF) and cell adhesion molecules expression (CAMs) in EC. Finally, we tested Q effects on neointima formation and re-endothelialization in a rat model of carotid artery angioplasty. Results: In SMC, all tested Q concentrations reduced proliferation, increased p53 expression and apoptosis. In contrast, EC, pro-apoptotic effects and TF activation were only observed after prolonged treatment with the highest dose, while CAMs expression was never induced at all concentrations. In vivo, Q induced p53 levels and apoptosis in the neointima, and significantly reduced neointimal formation without affecting re-endothelialization. Conclusion: Q exerts pro-apoptotic effects with higher selectivity for SMC, without pro-thrombotic effects, and might represent a safer drug to prevent or treat artery restenosis after percutaneous interventions.

33. Young Investigator Award session - Clinical Science

Author

Clerc, O F, Possner, M, Liga, R, Fuchs, T A, Dougoud, S, Stehli, J, Vontobel, J, Mikulicic, F, Kaufmann, P A, Gaemperli, O, Lima Da Silva, G, Almeida, A M G, David, C, Francisco, AR, Guimaraes, T, Placido, R, Menezes, M, Pinto, FJ, Jobbe Duval, A, Rimbert, A, Cueff, C, Lecointe, S, Hagege, AA, Levine, R, Merot, J, Le Marec, H, Schott, JJ, Le Tourneau, T, Santoro, C, Lembo, M, Esposito, R, Cocozza, S, Ilardi, F, Arpino, G, De Placido, S, De Simone, G, Trimarco, B, and Galderisi, M

Abstract

Purpose: Left bundle branch block (LBBB) is considered an unfavourable prognostic marker in heart disease. Testing for coronary artery disease (CAD) is often prompted by incidental LBBB finding, but published studies disagree about an association between LBBB and CAD. Thus, we assessed the association of LBBB with CAD in patients undergoing coronary CT angiography (CCTA). Methods: We enrolled 818 patients (106 LBBB patients and 712 controls) without known CAD, cardiomyopathy, valvular or congenital heart disease who underwent CCTA. Image quality was assessed on a 4-point scale for each coronary segment. After exclusion of non-diagnostic studies, comparison of CAD prevalence (≥50% coronary stenosis) was performed using triple case-matching for pre-test probability (based on age, gender and typicality of symptoms) in 101 LBBB patients and 303 matched controls. Results: Mean age was 57.2 ± 11.1 years. CAD prevalence did not differ between LBBB patients and matched controls: 15% vs. 16% (p=0.88). Similarly, no significant differences were found in cardiovascular risk factors (CVRF), stenosis severity, CAD extent, non-obstructive disease and vessel-based analysis. In multivariate analysis, age, gender, typical angina and CVRF, but not LBBB (p=0.94), emerged as significant and independent predictors of obstructive CAD. Image quality was very high in LBBB and controls (3.8 versus 3.9). LBBB did not affect image quality in multivariate analysis including technical factors (p=0.70). Conclusion: CAD prevalence is similar in LBBB patients at low-to-moderate pre-test probability compared to controls matched for age, gender, symptom typicality and CVRF. LBBB does not affect image quality in CCTA, which is therefore a useful imaging modality in LBBB patients. Prevalence of CAD by severity

Published
2015
Full Text
View/download PDF

34. Moderated Posters session: diastolic function in clinical perspective

Author

Fang, F, Li, YJ, Yang, J, Bartel, T, Erbel, R, Ya, Y, Yu, CM, Santoro, C, Schiano Lomoriello, V, Esposito, R, Casaretti, L, Ilardi, F, Fazio, V, De Simone, G, Trimarco, B, Galderisi, M, Hristova, K, Hristova, K, Marinov, R, Marinov, R, Katova, TZ, Katova, TZ, Kostova, V, Kostova, V, Simova, I, Yoon, HJ, Kim, KH, Cho, JY, Park, JC, Abid, L, Ben Kahla, S, Poller, A, Bech-Hanssen, O, Erdei, T, Sunderji, I, Sanchez-Martinez, S, Edwards, J, Braim, D, Price, C, Bijnens, B, Fraser, AG, Ahmed, T, Mohmed, LA, Abd-Elhady, B, Abdellaha, M, Mazen, A, Geraeli, B, Sattarzadeh Badkoubeh, R, Hassanbeigy, HR, Tavoosi, A, Larti, F, Saberi, K, Gascuena, R, Rubio, L, Terol, B, and Rico, C

Abstract

Background: Hypertension is a risk factor of coronary artery disease and also is associated with the impairment of coronary flow reserve (CFR). However, it remains unknown its effect on CFR in those with chest pain but without mild coronary stenosis. Methods: Fifty-four patients had no stenosis on coronary angiogram were enrolled. Transthoracic coronary Doppler echocardiography was performed in the distal left anterior descending coronary arterial baseline and after administration of adenosine (peak dose: 140 μg/kg/min) in those acceptable image quality and with minimal luminal cross-sectional area >4 mm2and a lumen area stenosis <50% tested by intravascular ultrasound examination (n=51). CFR was calculated with based on the hyperemic average peak velocity and baseline average peak velocity. Left ventricular (LV) function was assessed with conventional echocardiography including the evaluation of mitral annulus septal E’. Results: There were total 48 patients were finally analysis (3 excluded due to no septal E’) with the mean CFR of 2.89 ± 0.60. There were 25 with hypertension (52%), as a group, they lower CFR, lower septal E’ and as well more diastolic dysfunction (all P<0.05) (Table) despite similar age, gender distribution and LV volumes as well as ejection fraction. Further analysis showed that CFR was inversely associated with baseline systolic (r=-0.39, P=0.006) and diastolic blood pressure (r=-0.32, P=0.027) and correlated with Septal E’(r=0.63, P=0.012). In the multiple regression analysis, mitral spetal E’ was the only associated factor with CFR (β=0.29, P=0.041). Conclusion: In patients with chest pain but without significant coronary stenosis, CFR was lower in those with hypertension mainly via the diastolic dysfunction instead of baseline blood pressure. With Hypertension (n=25)Without hypertension (n=23)P valueLV end-diastolic volume, ml92 ± 3397 ± 250.491LV end-systolic volume, ml42 ± 839 ± 100.223LV ejection fraction, %58 ± 358 ± 50.767Coronary flow reserve2.7 ± 0.63.2 ± 0.5<0.001Mitral spetal E’, cm/s6.0 ± 1.68.0 ± 1.7<0.001LV diastolic function, n (%)16 (64%)4 (17%)χ2=10.707,P<0.001

Published
2015
Full Text
View/download PDF

35. Acute myocarditis: prognostic role of speckle tracking echocardiography and comparison with cardiac magnetic resonance features

Author

Federica Ilardi, Giovanna Esposito, Vincenzo Russo, Antonello D'Andrea, Gianluca Pontone, Giovanni Esposito, Giuseppe Muscogiuri, Ercole Tagliamonte, Andrea D'Amato, Alfonso Desiderio, Simona Sperlongano, Sperlongano, S, D'Amato, A, Tagliamonte, E, Russo, V, Desiderio, A, Ilardi, F, Muscogiuri, G, Esposito, G, Pontone, G, D'Andrea, A, Sperlongano, S., D'Amato, A., Tagliamonte, E., Russo, V., Desiderio, A., Ilardi, F., Muscogiuri, G., Esposito, G., Pontone, G., and D'Andrea, A.

Subjects
Adult, Male, medicine.medical_specialty, Myocarditis, Magnetic Resonance Spectroscopy, Cardiac magnetic resonance, Prognosi, Contrast Media, Magnetic Resonance Imaging, Cine, Speckle tracking echocardiography, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Gadolinium, Predictive Value of Test, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, Cicatrix, Young Adult, 0302 clinical medicine, Ventricular arrhythmias, Predictive Value of Tests, Internal medicine, Acute myocarditi, medicine, Humans, In patient, cardiovascular diseases, 030212 general & internal medicine, Acute myocarditis, Prognosis, business.industry, Ultrasound, Stroke Volume, Vascular surgery, Middle Aged, medicine.disease, Cardiac surgery, Echocardiography, Cardiology, Ventricular arrhythmia, Female, Cardiology and Cardiovascular Medicine, business, Human
Abstract

To evaluate longitudinal systolic function in patients with myocarditis, its correlation with cardiac magnetic resonance (CMR) features, and its predictive value in functional recovery and arrhythmias onset during follow-up (FU) on optimized medical therapy (OMT). Patients with acute myocarditis, confirmed through CMR criteria, and age- and sex-matched healthy controls were enrolled. Two-dimensional (2D) transthoracic echocardiography, including speckle tracking analysis, was performed at admission and after 6months of FU. Patients of myocarditis group also underwent 24h ECG Holter monitoring during FU. 115 patients with myocarditis (mean age 41 ± 17, 70% males) and 70 healthy subjects were enrolled. Global longitudinal strain (GLS) and sub-epicardial strain were markedly lower in the myocarditis group than in controls (mean GLS%: −14.1 ± 5.1 vs −23.1 ± 3.6, p < 0.001). A strong positive correlation between total scar burden (TSB) on CMR and baseline LV GLS was found (r = 0.67, p < 0.0001). GLS improved after 6months of FU in myocarditis on OMT (mean GLS%: −14.1 ± 5.1 vs −16.5 ± 4.8, p < 0.01). By bivariate correlation analysis, baseline LVEF, GLS, and TSB were all associated with LVEF at 6months of FU. Moreover, by multivariable linear regression analysis, these parameters confirmed to be independent predictors of functional recovery at 6months (LVEF β 0.38, p < 0.01; GLS β −0.35, p < 0.01; total scar burden β −0.52, p < 0.0001). Segmental peak systolic strain was significantly different between segments with and without late gadolinium enhancement on CMR (−13.2 ± 3.1% vs −18.1 ± 3.5%, p < 0.001). A segmental strain of − 12% identified scar with a sensitivity of 79% and a specificity of 84% (AUC = 0.91; 95% CI 0.73–0.97; p < 0.001). In addition, baseline LV GLS in myocarditis resulted predictive of non-sustained ventricular tachycardias (cut-off value > −12%; sensitivity84%; specificity74.4%; AUC = 0.75). Parameters of myocardial longitudinal deformation are importantly associated with the presence of a scar on CMR and are predictors of functional outcome and ventricular arrhythmias in patients with acute myocarditis. Their assessment during ultrasound examination should be considered to get more information about the prognosis and risk stratification of this subset of patients.

Published
2022

36. Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study

Author

Erwan Donal, Ralph Stephan von Bardeleben, Jose David Rodrigo Carbonero, Maurizio Galderisi, Simona Sperlongano, Monica Rosca, Caroline Piette, Roberta Manganaro, Daniele Barone, Adriana Postolache, Gonzalo de la Morena, Ciro Santoro, Federica Ilardi, Teresa López, George Kacharava, Bogdan A. Popescu, Monica Baroni, Elena Galli, Patrizio Lancellotti, Toshimitsu Tsugu, Julien Magne, Yun Yun Go, Dragos Vinereanu, Nuno Cardim, Marie Moonen, Julien Tridetti, Andreea Calin, José Luis Zamorano, Tolga Ozyigit, Krasimira Hristova, Martin Penicka, Mai-Linh Nguyen Trung, Bernard Cosyns, Raluca Elena Dulgheru, Alexandra Maria Chitroceanu, Tadafumi Sugimoto, George Athanassopoulos, Luigi P. Badano, Nico Van de Veire, Roberto M. Lang, Andreas Hagendorff, Tsugu, Toshimitsu, Postolache, Adriana, Dulgheru, Raluca, Sugimoto, Tadafumi, Tridetti, Julien, Nguyen Trung, Mai-Linh, Piette, Caroline, Moonen, Marie, Manganaro, Roberta, Ilardi, Federica, Chitroceanu, Alexandra Maria, Sperlongano, Simona, Go, Yun Yun, Kacharava, George, Athanassopoulos, George D, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andrea, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Drago, Zamorano, Jose Lui, Rosca, Monica, Calin, Andreea, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi P, Lang, Roberto M, Lancellotti, Patrizio, Tsugu, T., Postolache, A., Dulgheru, R., Sugimoto, T., Tridetti, J., Trung, M. -L. N., Piette, C., Moonen, M., Manganaro, R., Ilardi, F., Chitroceanu, A. M., Sperlongano, S., Go, Y. Y., Kacharava, G., Athanassopoulos, G. D., Barone, D., Baroni, M., Cardim, N., Hagendorff, A., Hristova, K., Lopez, T., de la Morena, G., Popescu, B. A., Penicka, M., Ozyigit, T., Carbonero, J. D. R., van de Veire, N., von Bardeleben, R. S., Vinereanu, D., Zamorano, J. L., Rosca, M., Calin, A., Magne, J., Cosyns, B., Galli, E., Donal, E., Santoro, C., Galderisi, M., Badano, L. P., Lang, R. M., Lancellotti, P., Clinical sciences, Cardio-vascular diseases, Cardiology, GIGA [Université Liège], Université de Liège, CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), GE Healthcare and Philips Healthcare, Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Tsugu, T, Postolache, A, Dulgheru, R, Sugimoto, T, Tridetti, J, Nguyen Trung, M, Piette, C, Moonen, M, Manganaro, R, Ilardi, F, Chitroceanu, A, Sperlongano, S, Go, Y, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, de la Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, van de Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Rosca, M, Calin, A, Magne, J, Cosyns, B, Galli, E, Donal, E, Santoro, C, Galderisi, M, Badano, L, Lang, R, and Lancellotti, P

Subjects
Adult, Male, medicine.medical_specialty, adult echocardiography, deformation imaging, Heart Ventricles, 030204 cardiovascular system & hematology, Ventricular Function, Left, Reference values, 2D echocardiography, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, reference values, Healthy volunteers, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Endocardium, Normal range, Strain (chemistry), business.industry, Myocardium, Healthy subjects, reference value, Mean age, General Medicine, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Middle Aged, Apex (geometry), Echocardiography, Cardiology, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Female, business, Large group, Cardiology and Cardiovascular Medicine, Human
Abstract

Aims To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages. Methods and results A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were −15.0% in men and −15.6% in women for epicardial strain, −16.8% and −17.7% for mid-myocardial strain, and −18.7% and −19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = −0.20, P = 0.007, mid-myocardial; r = −0.21, P = 0.006, endocardial; r = −0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1). Conclusion The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.

Published
2020
Full Text
View/download PDF

37. Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study

Author

Stella Marchetta, Anne Bernard, Ralph Stephan von Bardeleben, Elena Galli, Tadafumi Sugimoto, Concetta Zito, Maurizio Galderisi, Sébastien Robinet, Daniele Barone, Sara Cimino, Monica Baroni, Tolga Ozyigit, Yun Yun Go, Bernard Cosyns, Roberta Manganaro, Marie Moonen, Ciro Santoro, George Athanassopoulos, Gonzalo de la Morena, Scipione Carerj, Andreas Hagendorff, Erwan Donal, José Luis Zamorano, Nico Van de Veire, Federica Ilardi, Patrizio Lancellotti, Dragos Vinereanu, Bogdan A. Popescu, Monica Rosca, Raluca Elena Dulgheru, Krasimira Hristova, Nuno Cardim, Jose David Rodrigo Carbonero, Roberto M. Lang, Teresa López-Fernández, Luigi P. Badano, Andreea Calin, Cécile Oury, Julien Magne, Martin Penicka, George Kacharava, Clinical sciences, Cardio-vascular diseases, Cardiology, Manganaro, R, Marchetta, S, Dulgheru, R, Ilardi, F, Sugimoto, T, Robinet, S, Cimino, S, Go, Y, Bernard, A, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, López-Fernández, T, de la Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, van de Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Rosca, M, Calin, A, Moonen, M, Magne, J, Cosyns, B, Galli, E, Donal, E, Carerj, S, Zito, C, Santoro, C, Galderisi, M, Badano, L, Lang, R, Oury, C, Lancellotti, P, Centre Hospitalier Universitaire de Liège (CHU-Liège), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Universität Leipzig [Leipzig], Universidad de Alcalá - University of Alcalá (UAH), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), In vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel (VUB), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Messina, GE Healthcare, EACVI Research and Innovation Committee, Heart House, NORRE, Philips Healthcare, Manganaro, R., Marchetta, S., Dulgheru, R., Ilardi, F., Sugimoto, T., Robinet, S., Cimino, S., Go, Y. Y., Bernard, A., Kacharava, G., Athanassopoulos, G. D., Barone, D., Baroni, M., Cardim, N., Hagendorff, A., Hristova, K., Lopez-Fernandez, T., De La Morena, G., Popescu, B. A., Penicka, M., Ozyigit, T., Rodrigo Carbonero, J. D., Van De Veire, N., Von Bardeleben, R. S., Vinereanu, D., Zamorano, J. L., Rosca, M., Calin, A., Moonen, M., Magne, J., Cosyns, B., Galli, E., Donal, E., Carerj, S., Zito, C., Santoro, C., Galderisi, M., Badano, L. P., Lang, R. M., Oury, C., Lancellotti, P., Universität Leipzig, and Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, medicine.medical_specialty, adult echocardiography, Work efficiency, 030204 cardiovascular system & hematology, 2D echocardiography, 03 medical and health sciences, 0302 clinical medicine, Reference Values, Internal medicine, medicine.artery, Healthy volunteers, Medicine, Humans, Radiology, Nuclear Medicine and imaging, myocardial work, reference values, Prospective Studies, Brachial artery, adult echocardiography • 2D echocardiography • myocardial work • reference values, business.industry, Non invasive, Healthy subjects, reference value, Mean age, General Medicine, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Middle Aged, Europe, Blood pressure, Echocardiography, Heart Function Tests, Cardiology, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Cardiology and Cardiovascular Medicine, business, Large group, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience; Aims - To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. Methods and results - A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270 mmHg% and 1310 mmHg% for GWI, 1650 mmHg% and 1544 mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238 mmHg% in men and 239 mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women. Conclusion - The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW.

Published
2019
Full Text
View/download PDF

38. 3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study

Author

Nico Van de Veire, Erwan Donal, Dragos Vinereanu, Federica Ilardi, Tolga Ozyigit, Christophe Martinez, Karima Addetia, Anne Bernard, José Luis Zamorano, Julien Magne, Andreas Hagendorff, Daniele Barone, Teresa López, Jose David Rodrigo Carbonero, Gonzalo de la Morena, Roberto M. Lang, George Athanassopoulos, Nuno Cardim, Monica Baroni, Luigi P. Badano, Ralph Stephan von Bardeleben, Bernard Cosyns, Natela Akhaladze, Martin Penicka, Patrizio Lancellotti, Tadafumi Sugimoto, Gilbert Habib, Raluca Elena Dulgheru, Krasimira Hristova, Bogdan A. Popescu, Luis Caballero, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), University of Chicago, Cardio-vascular diseases, Clinical sciences, Bernard, A., Addetia, K., Dulgheru, R., Caballero, L., Sugimoto, T., Akhaladze, N., Athanassopoulos, G. D., Barone, D., Baroni, M., Cardim, N., Hagendorff, A., Hristova, K., Ilardi, F., Lopez, T., De La Morena, G., Popescu, B. A., Penicka, M., Ozyigit, T., Carbonero, J. D. R., Van De Veire, N., Von Bardeleben, R. S., Vinereanu, D., Zamorano, J. L., Martinez, C., Magne, J., Cosyns, B., Donal, E., Habib, G., Badano, L. P., Lang, R. M., Lancellotti, P., Bernard, A, Addetia, K, Dulgheru, R, Caballero, L, Sugimoto, T, Akhaladze, N, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Ilardi, F, Lopez, T, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Martinez, C, Magne, J, Cosyns, B, Donal, E, Habib, G, Badano, L, Lang, R, Lancellotti, P, Hospital Virgen de la Arrixaca, Murcia, Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, medicine.medical_specialty, Longitudinal strain, adult echocardiography, deformation imaging, Heart Ventricles, Cardiac Volume, Diastole, Echocardiography, Three-Dimensional, 030204 cardiovascular system & hematology, Ventricular Function, Left, Heart Ventricle, Reference values, 03 medical and health sciences, Young Adult, left ventricular function, 0302 clinical medicine, Internal medicine, Healthy volunteers, three-dimensional echocardiography, Medicine, Circumferential strain, Humans, Radiology, Nuclear Medicine and imaging, Reference Value, 030212 general & internal medicine, Systole, Aged, Ejection fraction, Strain (chemistry), business.industry, General Medicine, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Middle Aged, Healthy Volunteer, Healthy Volunteers, 3. Good health, Radiology Nuclear Medicine and imaging, Cardiology, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, business, Cardiology and Cardiovascular Medicine, Human
Abstract

International audience; Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of 440 (mean age: 45 ± 13 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets. Upper limits of LV end-diastolic and end-systolic volumes were larger in men (97 and 42 mL/m2) than in women (82 and 35 mL/m2; P

Published
2017
Full Text
View/download PDF

39. Impact of COVID-19 pandemic on timing and early clinical outcomes of transcatheter aortic valve implantation

Author

Domenico Angellotti, Rachele Manzo, Domenico Simone Castiello, Raffaele Piccolo, Marisa Avvedimento, Attilio Leone, Federica Ilardi, Andrea Mariani, Cristina Iapicca, Luigi Di Serafino, Plinio Cirillo, Anna Franzone, Giovanni Esposito, Angellotti, D., Manzo, R., Castiello, D. S., Piccolo, R., Avvedimento, M., Leone, A., Ilardi, F., Mariani, A., Iapicca, C., Di Serafino, L., Cirillo, P., Franzone, A., and Esposito, G.

Subjects
TAVI, outcome, COVID-19 pandemic, General Medicine, Cardiology and Cardiovascular Medicine, management
Abstract

Background: We sought to investigate the applicability and outcomes of a novel system to manage patients requiring transcatheter aortic valve implantation (TAVI) at a tertiary level hospital during the coronavirus disease-2019 (COVID-19) pandemic. Methods: To analyse the impact of hospitalisation pathways during the pandemic on clinical outcomes of TAVI patients, the study population was divided into two groups (pre-pandemic and pandemic groups) and all perioperative/follow-up data were compared. The primary endpoint was all-cause mortality at 30 days; secondary endpoints included procedural success and short-term complications. Results: A total of 315 patients received TAVI during the study period. Pandemic group (n = 77) showed a more complex baseline clinical profile (NYHA class III-IV, 70.1% vs. 56.3%; p = 0.03). The overall time to procedure was significantly longer during pandemic (56.9 ± 68.3 vs.37.7 ± 25.4; p = 0.004) while intensive care unit stay was shorter (2.2 ± 1.4 vs. 3.7 ± 3.9, p < 0.05). Hospitalisation length was similar in both groups as well as all-cause mortality rate and the incidence of major periprocedural complications. No case of infection by COVID-19 was reported among patients during the hospital stay. Conclusions: Comparative analysis of early clinical outcomes showed that COVID-19 pandemic did not affect the safety and effectiveness of TAVI as similar rates of procedural complications and all-cause mortality were reported than before February 2020. Despite the increased time lag between diagnosis and procedure and a more complex clinical profile of patients at baseline, the revised pathway of hospitalisation allowed to resume inpatient procedures while not affecting patients’ and healthcare workers’ safety.

Published
2022

40. Accuracy of global and regional longitudinal strain at peak of dobutamine stress echocardiography to detect significant coronary artery disease

Author

Adriana Postolache, Federica Ilardi, Giovanni Esposito, Patrick Marechal, Attilio Leone, Roberta Esposito, Ciro Santoro, Patrizio Lancellotti, Anna Sannino, Eugenio Stabile, Marisa Avvedimento, Raluca Elena Dulgheru, Plinio Cirillo, Giuseppe Giugliano, Ilardi, F., Santoro, C., Marechal, P., Dulgheru, R., Postolache, A., Esposito, R., Giugliano, G., Sannino, A., Avvedimento, M., Leone, A., Cirillo, P., Stabile, E., Lancellotti, P., and Esposito, G.

Subjects
Male, medicine.medical_specialty, Longitudinal strain, Dobutamine stress echocardiography, Coronary Artery Disease, 030204 cardiovascular system & hematology, Severity of Illness Index, 030218 nuclear medicine & medical imaging, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Dobutamine, medicine.artery, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Circumflex, Cardiac imaging, Aged, Speckle tracking, Original Paper, business.industry, Coronary Stenosis, Reproducibility of Results, Middle Aged, medicine.disease, Stenosis, medicine.anatomical_structure, Italy, Adrenergic beta-1 Receptor Agonists, Regional longitudinal strain, Right coronary artery, Cardiology, Feasibility Studies, Female, Cardiology and Cardiovascular Medicine, business, Echocardiography, Stress, Anterior myocardial ischemia, Artery
Abstract

Dobutamine stress echocardiography (DSE) is sensitive but subjective diagnostic tool to detect inducible ischemia. Nowadays, speckle tracking allows an objective quantification of regional wall function. We aimed to investigate the feasibility and accuracy of global (GLS) and regional longitudinal strain (RLS) during DSE to detect significant coronary stenosis (SCS). We conducted a prospective observational multicenter study including patients undergoing DSE for suspected SCS. 50 patients with positive DSE underwent coronary angiography. Besides visual regional wall motion score index (WMSI), GLS and RLS were determined at rest and at peak stress by Automated Function Imaging. DSE GLS feasibility was 96%. Among 35 patients with SCS, 12 patients were affected by multivessel disease, 18 had stenosis of left anterior descending artery (LAD), 18 of left circumflex (LCX) and 15 of right coronary artery (RCA). At peak stress, both GLS reduction (p = 0.037) and WMSI worsening (p = 0.04) showed significant agreement with coronary angiography for detecting SCS. When single lesion was considered, peak stress GLS and LAD RLS were lower in the obstructed LAD regions than in normo-perfused territories (17.4 ± 5.5 vs. 20.5 ± 4.4%, p = 0.03; 17.1 ± 7.6 vs. 21.6 ± 5.5%, p

Published
2021
Full Text
View/download PDF

41. COVID-19 Myocarditis: Prognostic Role of Bedside Speckle-Tracking Echocardiography and Association with Total Scar Burden

Author

Antonello D’Andrea, Luigi Cante, Stefano Palermi, Andreina Carbone, Federica Ilardi, Francesco Sabatella, Fabio Crescibene, Marco Di Maio, Francesco Giallauria, Giancarlo Messalli, Vincenzo Russo, Eduardo Bossone, D'Andrea, A., Cante, L., Palermi, S., Carbone, A., Ilardi, F., Sabatella, F., Crescibene, F., Di Maio, M., Giallauria, F., Messalli, G., Russo, V., Bossone, E., D'Andrea, Antonello, Cante, Luigi, Palermi, Stefano, Carbone, Andreina, Ilardi, Federica, Sabatella, Francesco, Crescibene, Fabio, Di Maio, Marco, Giallauria, Francesco, Messalli, Giancarlo, Russo, Vincenzo, and Bossone, Eduardo

Subjects
Adult, Male, Prognosi, SARS-CoV-2, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, COVID-19, Stroke Volume, Middle Aged, Prognosis, cardiac magnetic resonance, Ventricular Function, Left, Cicatrix, Myocarditis, myocarditis, speckle-tracking echocardiography, total scar burden, myocarditi, Echocardiography, Humans, RNA, Viral, Female, Human
Abstract

SARS-CoV2 infection, responsible for the COVID-19 disease, can determine cardiac as well as respiratory injury. In COVID patients, viral myocarditis can represent an important cause of myocardial damage. Clinical presentation of myocarditis is heterogeneous. Furthermore, the full diagnostic algorithm can be hindered by logistical difficulties related to the transportation of COVID-19 patients in a critical condition to the radiology department. Our aim was to study longitudinal systolic cardiac function in patients with COVID-19-related myocarditis with echocardiography and to compare these findings with cardiac magnetic resonance (CMR) results. Patients with confirmed acute myocarditis and age- and gender-matched healthy controls were enrolled. Both patients with COVID-19-related myocarditis and healthy controls underwent standard transthoracic echocardiography and speckle-tracking analysis at the moment of admission and after 6 months of follow-up. The data of 55 patients with myocarditis (mean age 46.4 ± 15.3, 70% males) and 55 healthy subjects were analyzed. The myocarditis group showed a significantly reduced global longitudinal strain (GLS) and sub-epicardial strain, compared to the control (p < 0.001). We found a positive correlation (r = 0.65, p < 0.0001) between total scar burden (TSB) on CMR and LV GLS. After 6 months of follow-up, GLS showed marked improvements in myocarditis patients on optimal medical therapy (p < 0.01). Furthermore, we showed a strong association between baseline GLS, left ventricular ejection fraction (LVEF) and TSB with LVEF at 6 months of follow-up. After a multivariable linear regression analysis, baseline GLS, LVEF and TSB were independent predictors of a functional outcome at follow-up (p < 0.0001). Cardiac function and myocardial longitudinal deformation, assessed by echocardiography, are associated with TSB at CMR and have a predictive value of functional recovery in the follow-up.

Published
2022

42. Epidemiology, prognosis, and clinical manifestation of cardiovascular disease in COVID-19

Author

Ciro Santoro, Vittoria Cuomo, Roberta Esposito, Giovanni Esposito, Mario Enrico Canonico, V Capone, Maria Prastaro, Federica Ilardi, Capone, V., Cuomo, V., Esposito, R., Canonico, M. E., Ilardi, F., Prastaro, M., Esposito, G., and Santoro, C.

Subjects
medicine.medical_specialty, Prognosi, Pneumonia, Viral, Comorbidity, Disease, 030204 cardiovascular system & hematology, Disease cluster, medicine.disease_cause, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, myocardial damage, cardiovascular disease, Epidemiology, Pandemic, Internal Medicine, Humans, cardiovascular risk factor, Medicine, 030212 general & internal medicine, Intensive care medicine, Pandemics, Coronavirus, SARS-CoV-2, Coronavirus Infection, business.industry, Incidence, Incidence (epidemiology), COVID-19, General Medicine, Prognosis, medicine.disease, Pneumonia, Cardiovascular Diseases, Coronavirus Infections, Cardiology and Cardiovascular Medicine, business, Human
Abstract

Introduction: At the end of 2019, a novel coronavirus was identified as the cause of a pneumonia cluster in Wuhan, China. Since then, the contagion has rapidly spread all over the world resulting in a global pandemic. Since frequent cardiovascular (CV) system involvement has soon been detected in patients occurring coronavirus disease 2019 (COVID-19), we would provide a simple review available to cardiologists who are going to be involved in the management of COVID-19 patients from several levels: from diagnosis to prevention and management of CV complications. Areas covered: We investigate the role of CV diseases in COVID-19: from incidence of CV comorbidities to their negative impact on prognosis. We also search Literature in order to identify the main CV manifestations in patients occurring virus infection and their management by cardiologists. Expert opinion: Specific treatments for CV involvement associated with COVID-19 are still debated. Results from ongoing trials are needed to further clarify issues about the therapeutic approach, which is constantly changing according the continuous flow of published evidences. Finally, it seems necessary to sensitize all population to raise awareness on CV diseases in COVID era, to hinder underestimation of both new-onset acute CV diseases and consequences of chronic mistreated CV diseases.

Published
2020
Full Text
View/download PDF

43. Effects of High Intensity Interval Training Rehabilitation Protocol after an Acute Coronary Syndrome on Myocardial Work and Atrial Strain

Author

Antonello D’Andrea, Andreina Carbone, Federica Ilardi, Mario Pacileo, Cristina Savarese, Simona Sperlongano, Marco Di Maio, Francesco Giallauria, Vincenzo Russo, Eduardo Bossone, Eugenio Picano, D'Andrea, A., Carbone, A., Ilardi, F., Pacileo, M., Savarese, C., Sperlongano, S., Di Maio, M., Giallauria, F., Russo, V., Bossone, E., and Picano, E.

Subjects
chronic coronary syndrome, Myocardium, strain, myocardial work, rehabilitation, cardiopulmonary test, acute coronary syndrome, echocardiography, diastole, left atrium, General Medicine, High-Intensity Interval Training, Humans, Heart Atria, Acute Coronary Syndrome, Exercise, Human, Randomized Controlled Trials as Topic
Abstract

Background andObjectives: Current guidelines on cardiac rehabilitation (CR) suggest moderate-intensity physical activity after acute coronary syndrome (ACS). Recent report have shown that high-intensity interval training (HIIT) could be more effective than moderate-intensity continuous training (MCT) in improving cardiac performance. Our aim was to analyze the effects of HIIT protocol after ACS on advanced echocardiographic parameters of myocardial function. Materials and Methods: In total, 75 patients with recent ACS, with or without ST segment elevation, were enrolled and compared with a control group of 50 age- and sex-comparable healthy subjects. Patients were randomized to perform a MCT training or HIIT-based rehabilitation program. A complete echocardiographic evaluation, including left ventricular (LV) and left atrial (LA) global longitudinal strain (GLS) and myocardial work (MW) through speckle-tracking analysis, was performed for all patients, before and after cardiac rehabilitation training. A cardiopulmonary exercise testing (CPET) was also performed at the end of the rehabilitation program. Results: Patients who followed the HIIT rehabilitation program showed improved LV diastolic function compared to the MCT group (E/e’: 3.4 ± 3.1 vs. 6.4 ± 2.8, respectively, p < 0.01). Similarly, LV systolic function showed significant improvement in the group of patients performing HIIT (ejection fraction: 53.1 ± 6.4 vs. 52.3 ± 5.4%, p < 0.01; GLS: −17.8 ± 3.8 vs. −15.4 ± 4.3, p < 0.01). In addition, LA strain was improved. MW efficiency was also increased in the HIIT group (91.1 ± 3.3 vs. 87.4 ± 4.1%, p < 0.01), and was closely related to peak effort measurements expressed in peak VO2 by CPET. Conclusions: In patients with recent ACS, the HIIT rehabilitation program determined reverse cardiac remodeling, with the improvement of diastolic and systolic function, assessed by standard echocardiography. In addition, cardiac deformation index as GLS, LA strain and MW efficiency improved significantly after HIIT, and were associated with functional capacity during effort.

Published
2022

44. Arterial Hypertension in Aortic Valve Stenosis: A Critical Update

Author

Anna Franzone, Maria Lembo, Federica Ilardi, Maria Virginia Manzi, Costantino Mancusi, Ilaria Fucile, Christian Basile, Basile, C., Fucile, I., Lembo, M., Manzi, M. V., Ilardi, F., Franzone, A., and Mancusi, C.

Subjects
Aortic valve, medicine.medical_specialty, medicine.drug_class, Review, Afterload, Pharmacokinetics, Internal medicine, Medicine, echocardiography, Antihypertensive drug, left ventricular remodeling, business.industry, General Medicine, Stroke volume, medicine.disease, Stenosis, medicine.anatomical_structure, Aortic valve stenosis, Cardiology, antihypertensive drug, Sodium nitroprusside, business, medicine.drug, high blood pressure
Abstract

Aortic stenosis (AS) is a very common valve disease and is associated with high mortality once it becomes symptomatic. Arterial hypertension (HT) has a high prevalence among patients with AS leading to worse left ventricle remodeling and faster degeneration of the valve. HT also interferes with the assessment of the severity of AS, leading to an underestimation of the real degree of stenosis. Treatment of HT in AS has not historically been pursued due to the fear of excess reduction in afterload without a possibility of increasing stroke volume due to the fixed aortic valve, but most recent evidence shows that several drugs are safe and effective in reducing BP in patients with HT and AS. RAAS inhibitors and beta-blockers provide benefit in selected populations based on their profile of pharmacokinetics and pharmacodynamics. Different drugs, on the other hand, have proved to be unsafe, such as calcium channel blockers, or simply not easy enough to handle to be recommended in clinical practice, such as PDE5i, MRA or sodium nitroprusside. The present review highlights all available studies on HT and AS to guide antihypertensive treatment.

Published
2021

45. The Role of Multimodality Imaging in Athlete’s Heart Diagnosis: Current Status and Future Directions

Author

Giovanni Benfari, Simona Sperlongano, Stefano Palermi, Vincenzo Russo, Francesca Renon, Francesco Giallauria, Antonello D'Andrea, Eduardo Bossone, Giuseppe Limongelli, Federica Ilardi, Flavio D'Ascenzi, D'Andrea, A., Sperlongano, S., Russo, V., D'Ascenzi, F., Benfari, G., Renon, F., Palermi, S., Ilardi, F., Giallauria, F., Limongelli, G., and Bossone, E.

Subjects
cardiomyopathies, medicine.medical_specialty, Myocarditis, Cardiac computed tomography, Cardiac magnetic resonance, stress echocardiography, Speckle tracking echocardiography, Disease, Review, sudden cardiac death, Sudden cardiac death, Strain, multimodality imaging, Internal medicine, medicine, Stress Echocardiography, echocardiography, Athlete’s heart, Cardiomyopathies, Echocardiography, Multimodality imaging, Stress echocardiography, Cardiomyopathie, business.industry, General Medicine, medicine.disease, Review article, medicine.anatomical_structure, Cardiology, Medicine, Differential diagnosis, business, athlete’s heart, Artery
Abstract

“Athlete’s heart” is a spectrum of morphological and functional changes which occur in the heart of people who practice physical activity. When athlete’s heart occurs with its most marked expression, it may overlap with a differential diagnosis with certain structural cardiac diseases, including cardiomyopathies, valvular diseases, aortopathies, myocarditis, and coronary artery anomalies. Identifying the underlying cardiac is essential to reduce the potential for sudden cardiac death. For this purpose, a spectrum of imaging modalities, including rest and exercise stress echocardiography, speckle tracking echocardiography, cardiac magnetic resonance, computed tomography, and nuclear scintigraphy, can be undertaken. The objective of this review article is to provide to the clinician a practical step-by-step approach, aiming at distinguishing between extreme physiology and structural cardiac disease during the athlete’s cardiovascular evaluation.

Published
2021

46. Extent of Cardiac Damage and Mortality in Patients Undergoing Transcatheter Aortic Valve Implantation

Author

Roberta Esposito, Anna Franzone, Luigi Di Serafino, Cristina Iapicca, Giovanni Esposito, Domenico Simone Castiello, Andrea Mariani, Attilio Leone, Federica Ilardi, Ciro Santoro, Marisa Avvedimento, Plinio Cirillo, Maria Scalamogna, Domenico Angellotti, Raffaele Piccolo, Avvedimento, M., Franzone, A., Leone, A., Piccolo, R., Castiello, D. S., Ilardi, F., Mariani, A., Esposito, R., Iapicca, C., Angellotti, D., Scalamogna, M., Santoro, C., Di Serafino, L., Cirillo, P., and Esposito, G.

Subjects
medicine.medical_specialty, Tricuspid valve, business.industry, Mortality rate, Diastole, General Medicine, staging, medicine.disease, mortality, Article, Stenosis, medicine.anatomical_structure, Internal medicine, Mitral valve, medicine, Cardiology, Risk of mortality, cardiovascular system, Medicine, cardiac damage, Myocardial infarction, Stage (cooking), business, transcatheter aortic valve implantation
Abstract

(1) Aims: We sought to assess the impact of the extent of cardiac damage on survival among real-world patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). (2) Methods: A staging classification was applied to 262 patients from the EffecTAVI Registry at baseline and re-assessed within 30-days after TAVI. The primary endpoint of the study was all-cause mortality at 1-year. Secondary endpoints included cerebrovascular accident, myocardial infarction, permanent pacemaker implantation, endocarditis, and re-hospitalization for all causes. (3) Results: At baseline, 23 (8.7%) patients were in Stage 0/1 (no cardiac damage/left ventricular damage), 106 (40.4%) in Stage 2 (left atrial or mitral valve damage), 59 (22.5%) in Stage 3 (pulmonary vasculature or tricuspid valve damage) and 74 (28.3%) in Stage 4 (right ventricular damage). At 30-days after TAVI, a lower prevalence of advanced stages of cardiac damage than baseline, mainly driven by a significant improvement in left ventricular diastolic parameters and right ventricular function, was reported. At 1-year, a stepwise increase in mortality rates was observed according to staging at baseline: 4.3% in Stage 0/1, 6.6% in Stage 2, 18.6% in Stage 3 and 21.6% in Stage 4 (p = 0.08). No differences were found in secondary endpoints. (4) Conclusions: TAVI has an early beneficial impact on the left ventricular diastolic and right ventricular function. However, the extent of cardiac damage at baseline significantly affects the risk of mortality at 1-year after the procedure.

Published
2021

47. Multimodality Imaging Is Key for a Successful Paravalvular Leak Repair

Author

Ilardi, Federica, Anastasius, Malcolm, Lerakis, Stamatios, Ilardi, F., Anastasius, M., and Lerakis, S.

Subjects
3-dimensional imaging, mitral valve, 3-dimensional printing, Case Report, computed tomography, valve repair, Cardiology and Cardiovascular Medicine, Editorial Comment
Abstract

Corresponding Author

Published
2022
Full Text
View/download PDF

48. An Emergent Form of Cardiotoxicity: Acute Myocarditis Induced by Immune Checkpoint Inhibitors

Author

Federica Ilardi, Mario Enrico Canonico, Maria Prastaro, Giovanni Esposito, Vittoria Cuomo, Roberta Esposito, Silvia Orefice, Francesco De Stefano, L Fiorillo, Teresa Fedele, Ciro Santoro, Esposito, R., Fedele, T., Orefice, S., Cuomo, V., Prastaro, M., Canonico, M. E., Ilardi, F., De Stefano, F., Fiorillo, L., Santoro, C., and Esposito, G.

Subjects
medicine.medical_specialty, Myocarditis, cardio-oncology, Immune Checkpoint Inhibitor, Myocarditi, Review, 030204 cardiovascular system & hematology, Biochemistry, Pericardial effusion, Microbiology, immune checkpoint inhibitors, 03 medical and health sciences, Pericarditis, 0302 clinical medicine, Neoplasms, Immune-related adverse event, Medicine, Animals, Humans, cancer, Myocardial infarction, Intensive care medicine, Adverse effect, Molecular Biology, Cardiotoxicity, business.industry, Animal, Cancer, medicine.disease, QR1-502, Discontinuation, 030220 oncology & carcinogenesis, Acute Disease, Neoplasm, immune-related adverse events, myocarditis, business, Human
Abstract

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that activate the immune system, aiming at enhancing antitumor immunity. ICIs have shown great promise in the treatment of several advanced malignancies. However, therapy with these immunomodulatory antibodies may lead to a wide spectrum of immune-related adverse events in any organ and any tissue. Cardiologic immune-related events include pericarditis, pericardial effusion, various types of arrhythmias including the occurrence of complete atrioventricular block, myocardial infarction, heart failure, and myocarditis. Although relatively rare, myocarditis is associated with a very high reported mortality in comparison to other adverse events. Myocarditis often presents significant diagnostic complexity and may be under-recognized. When confronted with an unexpected change in the clinical picture, the physician must differentiate between immune-related adverse events, cancer worsening, or other causes unrelated to the cancer or its therapy. However, this is not always easy. Therefore, with the increasing use of checkpoint inhibitors in cancer, all providers who care for patients with cancer should be made aware of this rare, but potentially fatal, cardiologic immune-related adverse event, and able to recognize when prompt consultation with a cardiologist specialist is indicated. In this review, we evaluate currently available scientific evidence and discuss clinical manifestations and new potential approaches to the diagnosis and therapy of acute myocarditis induced by ICIs. Temporary or permanent discontinuation of the ICIs and high-dose steroids have been administered to treat myocarditis, but symptoms may worsen in some patients despite therapy.

Published
2021

49. Myocardial work by echocardiography: Principles and applications in clinical practice

Author

Federica Ilardi, Antonello D’Andrea, Flavio D’Ascenzi, Francesco Bandera, Giovanni Benfari, Roberta Esposito, Alessandro Malagoli, Giulia Elena Mandoli, Ciro Santoro, Vincenzo Russo, Mario Crisci, Giovanni Esposito, Matteo Cameli, on behalf of the Working Group of Echocardiography of the Italian Society of Cardiology (SIC), Ilardi, F., D'Andrea, A., D'Ascenzi, F., Bandera, F., Benfari, G., Esposito, R., Malagoli, A., Mandoli, G. E., Santoro, C., Russo, V., Crisci, M., Esposito, G., and Cameli, M.

Subjects
medicine.medical_specialty, Pressure-strain loop, Ejection fraction, Longitudinal strain, business.industry, Myocardial function, Myocardial work, Pressure-strain loops, Speckle tracking, Strain, Work (physics), Objective method, Review, General Medicine, Systolic function, Clinical Practice, Internal medicine, pressure-strain loops, medicine, Cardiology, Medicine, business
Abstract

Left ventricular (LV) global longitudinal strain (GLS) has established itself in the last decade as a reliable, more objective method for the evaluation of LV systolic function, able to detect subtle abnormalities in LV contraction even in the presence of preserved ejection fraction (EF). However, recent studies have demonstrated that GLS, similar to LV EF, has important load dependency. Non-invasive myocardial work (MW) quantification has emerged in the last years as an alternative tool for myocardial function assessment. This new method, incorporating measurement of strain and LV pressure, has shown to overcome GLS and LV EF limitations and provide a loading-independent evaluation of myocardial performance. The presence of a commercially available echocardiographic software for the non-invasive MW calculation has allowed the application of this new method in different settings. This review sought to provide an overview on the current knowledge of non-invasive MW estimation, showing its potential applications and possible added value in clinical practice.

Published
2021

50. Left ventricular deformation and vortex analysis in heart failure: From ultrasound technique to current clinical application

Author

Roberta Bottino, Francesco Giallauria, Marco Di Maio, Federica Ilardi, Valeria Pergola, Eduardo Bossone, Vincenzo Russo, Paolo Golino, Donato Mele, Andreina Carbone, Antonello D'Andrea, Simona Sperlongano, Sperlongano, S., D'Andrea, A., Mele, D., Russo, V., Pergola, V., Carbone, A., Ilardi, F., Di Maio, M., Bottino, R., Giallauria, F., Bossone, E., and Golino, P.

Subjects
cardiac resynchronization therapy (CRT), medicine.medical_specialty, Medicine (General), medicine.medical_treatment, Clinical Biochemistry, Cardiac resynchronization therapy, Speckle tracking echocardiography, Context (language use), Review, 030204 cardiovascular system & hematology, Intracardiac injection, Color Doppler flow mapping (CDFM), 03 medical and health sciences, 0302 clinical medicine, R5-920, Internal medicine, medicine, Speckle tracking echocardiography (STE), 030212 general & internal medicine, Modalities, business.industry, Ultrasound, Heart failure with preserved ejection fraction (HFpEF), medicine.disease, Review article, Left ventricular vortex, Left ventricular strain, Heart failure (HF), Cardiac resyn-chronization therapy (CRT), Heart failure, Cardiology, color Doppler flow mapping (CDFM), heart failure (HF), heart failure with preserved ejection fraction (HFpEF), left ventricular strain, left ventricular vortex, speckle tracking echocardiography (STE), business
Abstract

Heart failure (HF) is a leading cause of cardiovascular morbidity and mortality. However, its symptoms and signs are not specific or can be absent. In this context, transthoracic echocardiography plays a key role in diagnosing the various forms of HF, guiding therapeutic decision making and monitoring response to therapy. Over the last few decades, new ultrasound modalities have been introduced in the field of echocardiography, aiming at better understanding the morpho-functional abnormalities occurring in cardiovascular diseases. However, they are still struggling to enter daily and routine use. In our review article, we turn the spotlight on some of the newest ultrasound technologies; in particular, analysis of myocardial deformation by speckle tracking echocardiography, and intracardiac flow dynamics by color Doppler flow mapping, highlighting their promising applications to HF diagnosis and management. We also focus on the importance of these imaging modalities in the selection of responses to cardiac resynchronization therapy.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results