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10 results on '"Iksanova, Alfiya G."'

6. Synthesis, antitumor activity and structure-activity studies of novel pyridoxine-based bioisosteric analogs of estradiol

Author

Pugachev, Mikhail V., primary, Pavelyev, Roman S., additional, Nguyen, Thang N.T., additional, Gabbasova, Raylya R., additional, Bulatov, Timur.M., additional, Iksanova, Alfiya G., additional, Aljondi, Bashar, additional, Bondar, Oksana V., additional, Grishaev, Denis Yu., additional, Yamaleeva, Zilya R., additional, Kataeva, Olga N., additional, Nikishova, Tatyana V., additional, Balakin, Konstantin V., additional, and Shtyrlin, Yurii G., additional

Published
2021
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7. Novel Bis-Ammonium Salts of Pyridoxine: Synthesis and Antimicrobial Properties

Author

Shtyrlin, Nikita V., primary, Pugachev, Mikhail V., additional, Sapozhnikov, Sergey V., additional, Garipov, Marsel R., additional, Vafina, Rusalia M., additional, Grishaev, Denis Y., additional, Pavelyev, Roman S., additional, Kazakova, Renata R., additional, Agafonova, Mariya N., additional, Iksanova, Alfiya G., additional, Lisovskaya, Svetlana A., additional, Zeldi, Marina I., additional, Krylova, Elena S., additional, Nikitina, Elena V., additional, Sabirova, Alina E., additional, Kayumov, Airat R., additional, and Shtyrlin, Yurii G., additional

Published
2020
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8. Author Correction: Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus

Author

Dzyurkevich, Mikhail S., primary, Babkov, Denis A., additional, Shtyrlin, Nikita V., additional, Mayka, Olga Yu., additional, Iksanova, Alfiya G., additional, Vassiliev, Pavel M., additional, Balakin, Konstantin V., additional, Spasov, Alexander A., additional, Tarasov, Vadim V., additional, Barreto, George, additional, Shtyrlin, Yurii G., additional, and Aliev, Gjumrakch, additional

Published
2018
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9. Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus

Author

Dzyurkevich, Mikhail S., primary, Babkov, Denis A., additional, Shtyrlin, Nikita V., additional, Mayka, Olga Yu., additional, Iksanova, Alfiya G., additional, Vassiliev, Pavel M., additional, Balakin, Konstantin V., additional, Spasov, Alexander A., additional, Tarasov, Vadim V., additional, Barreto, George, additional, Shtyrlin, Yurii G., additional, and Aliev, Gjumrakch, additional

Published
2017
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10. Synthesis and Antibacterial Activity of Novel Quaternary Ammonium Pyridoxine Derivatives.

Author

Shtyrlin NV, Sapozhnikov SV, Koshkin SA, Iksanova AG, Sabirov AH, Kayumov AR, Nureeva AA, Zeldi MI, and Shtyrlin YG

Subjects
Anti-Bacterial Agents chemistry, Anti-Bacterial Agents toxicity, Bacteria drug effects, Chemistry Techniques, Synthetic, Hydrophobic and Hydrophilic Interactions, Microbial Sensitivity Tests, Mutagenicity Tests, Pyridoxine chemistry, Pyridoxine toxicity, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents pharmacology, Pyridoxine chemical synthesis, Pyridoxine pharmacology, Quaternary Ammonium Compounds chemistry
Abstract

A series of 26 quaternary ammonium pyridoxine derivatives were synthesized and their cytotoxicity and antibacterial activities against clinically relevant bacterial strains were tested in vitro. The antibacterial activity of mono-ammonium salts increased with the rise of the lipophilicity and compound 3,3,5-trimethyl-8,8-dioctyl-1,7,8,9-tetrahydro-[1,3]dioxino[5,4-d]pyrrolo[3,4-b]pyridin-8-ium chloride (2d) reaches a maximum among them. Bis-ammonium salt of pyridoxine 4 with two dimethyloctylamine groups also demonstrated high antibacterial activity despite lower lipophilicity. The results of MTT assay indicated that HEK 293 cells were more sensitive than HSF to quaternary ammonium pyridoxine derivatives. Compounds 2d and 4 did not induce the damage of the DNA and might be of interest in the development of new antimicrobials.

Published
2015
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