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This study developed a volcanic disaster risk reduction education program that aims to help junior high school students visually understand the risks of volcanic eruptions using map information and acquire independent assessments and actions to protect their own lives from eruption disasters. First, this program analyzed the present state, problems, and educational needs of volcanic disaster risk reduction education in Japan, and thereafter designed the learning content to fuse information and communication technology (ICT) education based on the Global and Innovation Gateway for All (GIGA) School Initiative promoted by Japan with disaster risk reduction education from a geographical viewpoint. We adopted the ADDIE model from instructional design theory to develop the program. An important feature of this program is the realization of geography learning using the "YOU@RISK Volcanic Disaster Edition," a web-based GIS application developed by the National Research Institute for Earth Science and Disaster Resilience (NIED), as an ICT tool. Learners use YOU@RISK on their tablets and perform operations such as visualizing the risk range in the event of a volcanic eruption and searching for appropriate evacuation sites and routes, while acquiring the knowledge and skills necessary for geographical literacy and emergency response actions. The program is able to realize interactive learning, which is a step ahead of education that relies on conventional paper-based hazard maps. Among active volcanoes nationwide, Mt. Nasu was selected as target volcano for this study. In addition, a junior high school located in the area surrounding Mt. Nasu, Nasu Junior High School in Nasu Town, Tochigi Prefecture, was selected as the target school. The program was implemented by teachers using tablets provided for each student at the school. We evaluated the effectiveness of the program by measuring and analyzing the effects of learning through the practice. Consequently, the effectiveness of the volcanic disaster risk reduction education program using ICT was confirmed. [ABSTRACT FROM AUTHOR]

Objective: Multisystem proteinopathy (MSP) is an inherited disorder in which protein aggregates with TAR DNA‐binding protein of 43 kDa form in multiple organs. Mutations in VCP, HNRNPA2B1, HNRNPA1, SQSTM1, MATR3, and ANXA11 are causative for MSP. This study aimed to conduct a nationwide epidemiological survey based on the diagnostic criteria established by the Japan MSP study group. Methods: We conducted a nationwide epidemiological survey by administering primary and secondary questionnaires among 6235 specialists of the Japanese Society of Neurology. Results: In the primary survey, 47 patients with MSP were identified. In the secondary survey of 27 patients, inclusion body myopathy was the most common initial symptom (74.1%), followed by motor neuron disease (11.1%), frontotemporal dementia (FTD, 7.4%), and Paget's disease of bone (PDB, 7.4%), with no cases of parkinsonism. Inclusion body myopathy occurred most frequently during the entire course of the disease (81.5%), followed by motor neuron disease (25.9%), PDB (18.5%), FTD (14.8%), and parkinsonism (3.7%). Laboratory findings showed a high frequency of elevated serum creatine kinase levels and abnormalities on needle electromyography, muscle histology, brain magnetic resonance imaging, and perfusion single‐photon emission computed tomography. Interpretation: The low frequency of FTD and PDB may suggest that FTD and PDB may be widely underdiagnosed and undertreated in clinical practice. [ABSTRACT FROM AUTHOR]

In this study, we analyzed the disaster management education programs implemented by organizations included in the Disaster Management Education Challenge Plan, a program established to support disaster management education efforts in Japan. We examined the changes in these programs and identified the current state and issues in the promotion of disaster education in Japan by classifying the contents. The study methodology involved creating data sets of the program reports submitted from fiscal year (FY) 2004 to FY2021 by organizations admitted to the Disaster Management Education Challenge Plan, and evaluating them on scales of "fundamental skills of disaster management" and "factors regarding implementing the programs." Analysis of the former found that there were few programs aimed at acquiring a scientific understanding of disasters as natural phenomena or learning about measures to prevent damage at normal times. Cluster analysis yielded eight clusters, based on which we discussed and proposed ways to implement the programs in order to improve the "fundamental skills of disaster management." Similarly, analysis of the latter identified issues with regard to program logistics, such as securing financial resources and cultivating future successors. Cluster analysis yielded five clusters, based on which we discussed and proposed ways to effectively implement the programs. [ABSTRACT FROM AUTHOR]

This study examines the effect of the recognition of various disaster scenarios on the disaster management behavior of people. It analyzes the data (n = 1,900) of the social surveys, conducted by the National Research Institute for Earth Science and Disaster Resilience (NIED) in seven districts of Japan (Hokkaido/Tohoku, Kanto, Chubu, Kinki, Chugoku, Shikoku, and Kyushu). The study indicates that the experience of victims, recognition of earthquake occurrence in the region and of earthquake hazard maps, as well as the factors, "life threatening," "difficulties in daily life," and "induced disasters," in the disaster scenarios are related to their disaster management behavior. The greater their recognition of "life threatening" and "difficulties in daily life," the more people will adopt disaster management behaviors. This study suggests that, added to the experience of victims and the recognition of the occurrence of earthquakes and of hazard maps, the image of the damage through specific disaster scenarios affects people's disaster management behavior. On the other hand, it has become apparent that creating images of "induced disasters" that are caused by earthquakes, with their unclear association, may lead to psychological confusion. [ABSTRACT FROM AUTHOR]

Purpose Interleukin (IL)-25 and IL-33 induce IL-5 production by various types of cells, such as type 2 helper T (Th2) cells and type 2 innate lymphoid cells. The number of Th2 cells and concentration of IL-5 in the bronchoalveolar lavage fluid (BALF) are increased in patients with eosinophilic pneumonia (EP). To examine the contribution of IL-25 and IL-33 to eosinophilic inflammation of the lung in humans, we evaluated IL-5, IL-25 and IL-33 levels in the BALF of patients with EP. Methods IL-5, IL-25, and IL-33 concentrations in the BALF were measured by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), idiopathic pulmonary fibrosis (IPF), and sarcoidosis. Results The absolute number of eosinophils, and IL-5 levels, but not IL-33 levels, in the BALF were significantly higher in patients with EP than in patients with IPF and sarcoidosis. IL-25 levels in the BALF were significantly higher in patients with CEP, but not in patients with AEP, than in patients with IPF and sarcoidosis. The absolute number of eosinophils was significantly correlated with the IL-5 concentration in the BALF of patients with EP. IL-5 concentrations were significantly correlated with IL-25 concentrations in the BALF of patients with CEP, but not in patients with AEP. IL-5 levels were not correlated with IL-33 levels in the BALF of patients with EP. Conclusions Our findings suggest that IL-25 plays an important role via IL-5 in eosinophilic lung inflammation in patients with CEP., Author(s): Shigeki Katoh [sup.1] , Masaki Ikeda [sup.1] , Nobuhiro Matsumoto [sup.2] , Hiroki Shimizu [sup.1] , Masaaki Abe [sup.1] , Yoshihiro Ohue [sup.1] , Keiji Mouri [sup.1] , Yoshihiro [...]

Purpose Galectin-9 (Gal-9) is a β-galactoside-binding protein that exhibits various biological reactions, such as chemoattraction, cell aggregation, and apoptosis. Recent studies demonstrated that Gal-9 has a role as an immunomodulator in excessive immunological reactions by expanded regulatory T cells (Tregs). We examined the role of Gal-9 in the pathogenesis of one of the major idiopathic interstitial pneumonias, cryptogenic organizing pneumonia (COP) as compared with idiopathic pulmonary fibrosis (IPF). Methods Gal-9, transforming growth factor-p1, and interleukin (IL)-10 levels in the bronchoalveolar lavage fluid (BALF) of patients with COP and IPF were estimated by enzyme-linked immunosorbent assay. Forkhead box protein 3 (Foxp3) expressing Tregs were evaluated by flow cytometry. The effect of Gal-9 on interactions between human lung fibroblast cells and hyarulonan was assessed in vitro. Results Gal-9 and IL-10 levels in the BALF were significantly higher in patients with COP than in patients with IPF. The number of CD4+Foxp3high+cells was significantly higher in the BALF of patients with COP than in those with IPF. Gal-9 levels significantly correlated with the absolute number of CD4+CD25+Foxp3+cells or CD4+Foxp3high+ cells, but not with the absolute number of CD4+CD25+ Foxp3-cells, in the BALF of patients with COP. Gal-9 suppressed the CD44-dependent interaction of human lung fibroblast cells with hyarulonan in a dose-dependent manner. Conclusions Our findings suggest that increased Gal-9 levels in the lung have a protective role against lung inflammation and fibrosis in patients with COP through the induction of Tregs in the lung and CD44-dependent inhibitory effects on lung fibroblast cells. Keywords Galectin-9 * Regulatory T cells * Cryptogenic organizing pneumonia * Lung fibrosis * Bronchoalveolar lavage fluid, Introduction Idiopathic interstitial pneumonias (IIPs) are diffuse interstitial lung diseases resulting from damage to the lung parenchyma caused by the infiltration of fibroblasts with an unknown etiology. The American Thoracic [...]