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11. バドミントンの素振り練習による身体トレーニングについての検討

Author

阿部, 一佳, 須田, 和裕, 鵤木, 秀夫, 加藤, 幸司, Abe, Kazuyoshi, Suda, Kazuhiro, Ikarugi, Hideo, Katou, Koujji, アベ, カズヨシ, スダ, カズヒロ, イカルギ, ヒデオ, カトウ, コウジ, 阿部, 一佳, 須田, 和裕, 鵤木, 秀夫, 加藤, 幸司, Abe, Kazuyoshi, Suda, Kazuhiro, Ikarugi, Hideo, Katou, Koujji, アベ, カズヨシ, スダ, カズヒロ, イカルギ, ヒデオ, and カトウ, コウジ

Abstract

http://www.tulips.tsukuba.ac.jp/mylimedio/dl/page.do?issueid=102359843&old_issueid=413946&tocid=100058651&page=49-58

Published
2011

16. Görög Thrombosis Test

Author

Yamamoto, Junichiro, primary, Yamashita, Tsutomu, additional, Ikarugi, Hideo, additional, Taka, Tomomi, additional, Hashimoto, Masaru, additional, Ishii, Hiromitsu, additional, Watanabe, Sadahiro, additional, and Kovacs, Iren B, additional

Published
2003
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22. High Intensity Exercise Enhances Platelet Reactivity to Shear Stress and Coagulation during and after Exercise

Author

Ikarugi, Hideo, Shibata, Masashi, Shibata, Shiori, Ishii, Hiromitsu, Taka, Tomomi, and Yamamoto, Junichiro

Abstract

Platelets play a crucial role in the pathogenesis of acute cardiac events, such as angina, myocardial infarction and sudden death. It is believed that regular low-intensity exercise can reduce, while high-intensity exercise may provoke acute cardiac events. The aim of the present study was to investigate the effect of acute exercise both at low and high intensities on the ventilatory threshold (VT), platelet reactivity and coagulation before and after exercise. Platelet reactivity and coagulation were measured under flow condition, using native blood, by hemostatometry. Seven healthy young men (age: 20–29 years) performed bicycle ergometer exercise for 30 min at intensities of 90% (Ex-VT90% or approximately 55% VO2max) and 130% (Ex-VT130% or 80% VO2max) of individual VT. Blood cell counts, hematocrit, blood lactic acid and plasma catecholamine levels were slightly but significantly increased after Ex-VT90% and markedly after Ex-VT130% after 30 min exercise. Subsequent to the exercise, the elevated blood cell counts decreased to the resting levels both at Ex-VT90% and at Ex-VT130%. Platelet reactivity to shear stress and dynamic coagulation were significantly enhanced immediately and 30 min after Ex-130%VT. In contrast, no significant changes occurred in those of Ex-90%VT. The present study suggests that high-intensity exercise-induced platelet hyperreactivity and hypercoagulable state may pose an increased risk for acute, sometimes fatal cardiac event. On the other hand, our findings support the view that low-intensity exercise does not present a risk of thrombosis.

Published
2004
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24. Shear rate-dependent thrombosis/fibrinolysis tests using non-anticoagulated blood could be useful in the prevention of thrombotic disorders.

Author

Yamamoto J, Ijiri Y, Shimizu M, Yamamoto S, Ikarugi H, and Sakariassen KS

Abstract

Competing Interests: Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

Published
2018
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25. Görög Thrombosis Test: a global in-vitro test of platelet function and thrombolysis.

Author

Yamamoto J, Yamashita T, Ikarugi H, Taka T, Hashimoto M, Ishii H, Watanabe S, and Kovacs IB

Subjects
Adult, Antifibrinolytic Agents, Clot Retraction, Cytochalasin B pharmacology, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Plasminogen Activators antagonists & inhibitors, Plasminogen Activators pharmacology, Platelet Aggregation Inhibitors pharmacology, Platelet Function Tests methods, Thrombosis drug therapy, Tranexamic Acid pharmacology, Fibrinolysis drug effects, Platelet Function Tests instrumentation, Thrombosis diagnosis
Abstract

This is the first laboratory evaluation of a new instrument, designed to test both platelet function and thrombolytic activity from a native blood sample, in vitro. The inventor assumed that the reduction and arrest of blood flow was due to activation, aggregation and stabilized thrombus formation by shear-activated platelets, and that re-establishment of flow was due to thrombolysis. Morphologic and functional studies presented here confirm these mechanisms. In vitro tests provided incontestable evidence for the principal role of platelets in the obstruction of flow (occlusion time) and for thrombolysis as the principal mechanism underlying the restoration of blood flow (lysis time). In addition to aggregation, it is the explosive generation of thrombin by shear-activated platelets that results in the formation of an occlusive haemostatic thrombus. Anticoagulation of blood completely prevented occlusion. Platelet-rich thrombus formation (occlusion time) was dose-dependently inhibited by monoclonal antibody against platelet glycoprotein (GP) Ib (6B4 and 12E4), aurin tricarboxylic acid, monoclonal antibody against platelet GPIIb/IIIa (MA-16N7C2 and abciximab), a synthetic GPIIb/IIIa antagonist (TAK-029), thrombin inhibitor (argatroban), and anti-von Willebrand factor, but not by anti-fibrinogen. Plasminogen activator streptokinase (Varidase) and tissue-type plasminogen activator (Monteplase) dose-dependently enhanced thrombolysis (lysis time) without affecting platelet function (occlusion time). The test is specific for thrombolysis. The plasmin inhibitor tranexamic acid prevented plasminogen activator-induced thrombolysis, while inhibition of clot retraction by cytochalasin B did not affect the lysis time. This rapid and sensitive global test of platelet function and thrombolytic activity could be of great value both in research and in clinical practice., (Copyright 2003 Lippincott Williams & Wilkins)

Published
2003
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