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35 results on '"Iida, Tomoko"'

1. Neuroradiological, genetic and clinical characteristics of histone H3 K27-mutant diffuse midline gliomas in the Kansai Molecular Diagnosis Network for CNS Tumors (Kansai Network): multicenter retrospective cohort

Author

Hayashi, Nobuhide, Fukai, Junya, Nakatogawa, Hirokazu, Kawaji, Hiroshi, Yoshioka, Ema, Kodama, Yoshinori, Nakajo, Kosuke, Uda, Takehiro, Naito, Kentaro, Kijima, Noriyuki, Okita, Yoshiko, Kagawa, Naoki, Takahashi, Yoshinobu, Hashimoto, Naoya, Arita, Hideyuki, Takano, Koji, Sakamoto, Daisuke, Iida, Tomoko, Arakawa, Yoshiki, Kawauchi, Takeshi, Sonoda, Yukihiko, Mitobe, Yuta, Ishibashi, Kenichi, Matsuda, Masahide, Achiha, Takamune, Tomita, Takahiro, Nonaka, Masahiro, Hara, Keijiro, Takebe, Noriyoshi, Tsuzuki, Takashi, Nakajima, Yoshikazu, Ohue, Shiro, Nakajima, Nobuyuki, Watanabe, Akira, Inoue, Akihiro, Umegaki, Masao, Kanematsu, Daisuke, Katsuma, Asako, Sumida, Miho, Shofuda, Tomoko, Mano, Masayuki, Kinoshita, Manabu, Mori, Kanji, Nakao, Naoyuki, and Kanemura, Yonehiro

Published
2024
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3. Psychometrics of rating scales for externalizing disorders in Japanese outpatients: The ADHD‐Rating Scale‐5 and the Disruptive Behavior Disorders Rating Scale

Author

Ishibashi, Saeko, primary, Nishiyama, Takeshi, additional, Makino, Takuya, additional, Suzuki, Futoshi, additional, Shimada, Shoko, additional, Tomari, Shinji, additional, Imanari, Eiji, additional, Higashi, Takuma, additional, Fukumoto, Shintaro, additional, Kurata, Sawa, additional, Mizuno, Yoshifumi, additional, Morimoto, Takeshi, additional, Nakamichi, Hidetaka, additional, Iida, Tomoko, additional, Ohashi, Kei, additional, Yamada, Atsurou, additional, Kimura, Takuma, additional, Kuru, Yukiko, additional, Sumi, Satoshi, additional, Tanaka, Yasuo, additional, Ono, Kazuya, additional, Ichikawa, Hironobu, additional, DuPaul, George J., additional, and Kosaka, Hirotaka, additional

Published
2024
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7. Psychometrics of the kiddie schedule for affective disorders and schizophrenia present and lifetime version for DSM‐5 in Japanese outpatients.

Author

Makino, Takuya, Suzuki, Futoshi, Nishiyama, Takeshi, Ishibashi, Saeko, Nakamichi, Hidetaka, Iida, Tomoko, Shimada, Shoko, Tomari, Shinji, Imanari, Eiji, Higashi, Takuma, Fukumoto, Shintaro, Kurata, Sawa, Mizuno, Yoshifumi, Kimura, Takuma, Kuru, Yukiko, Morimoto, Takeshi, and Kosaka, Hirotaka

Subjects
AFFECTIVE disorders, CHILD Behavior Checklist, ADOLESCENT psychiatry, PSYCHOMETRICS, CHILD psychiatry
Abstract

Objective: The Schedule for Affective Disorders and Schizophrenia for School‐Age Children‐Present and Lifetime version (K‐SADS‐PL) is a widely used semi‐structured diagnostic interview in child and adolescent psychiatry. However, the psychometric properties of its updated version, the K‐SADS‐PL for DSM‐5, have scarcely been examined, especially for criterion validity. This study was designed to examine the inter‐rater reliability, criterion validity and construct validity of the K‐SADS‐PL for DSM‐5 in 137 Japanese outpatients. Methods: Two of 12 experienced clinicians independently performed the K‐SADS interview for each patient in a conjoint session, and the resulting consensus diagnosis was compared with a "best‐estimate" diagnosis made by two of eight experienced clinicians using all available information for the patient. Results: The inter‐rater reliability was excellent, as shown by κ > 0.75 for all disorders, with the exception of current separation anxiety disorder. The criterion validity was fair to good, as shown by κ > 0.40 for all disorders, with the exception of current and lifetime agoraphobia. The construct validity was also good, as shown by theoretically expected associations between the K‐SADS‐PL diagnoses and subscales of the child behavior checklist. Conclusion: The K‐SADS‐PL for DSM‐5, now available in Japanese, generates valid diagnoses in child and adolescent psychiatry. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Randomized Controlled Trial of Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke: ASSORT Trial (Administration of Statin on Acute Ischemic Stroke Patient)

Author

Yoshimura, Shinichi, Uchida, Kazutaka, Daimon, Takashi, Takashima, Ryuzo, Kimura, Kazuhiro, Morimoto, Takeshi, Tanada, Shuichi, Iida, Tomoko, Kuroda, Junko, Nose, Akinori, Tatebayashi, Kotaro, Shimizu, Fuminori, Tsudaka, Shun, Takeuchi, Masataka, Hiyama, Nagayasu, Oki, Yoshiharu, Hagii, Joji, Saito, Shin, Matsumoto, Tsuyoshi, Tanaka, Yasue, Kuramoto, Yoji, Mikami, Kazuyuki, Shinoda, Narihide, Shimo, Daisuke, Soneda, Junichi, Tokuda, Kou, Matsuda, Kenichi, Hiroto, Kakita, Yamaura, Ikuya, Okada, Takashi, Hirano, Teruyuki, Kuwayama, Naoya, and Teramukai, Satoshi

Published
2017
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17. Affinity regulates spatial range of EGF receptor autocrine ligand binding

Author

DeWitt, Ann, Iida, Tomoko, Lam, Ho-Yan, Hill, Virginia, Wiley, H. Steven, and Lauffenburger, Douglas A.

Subjects
Developmental biology, Genetic regulation -- Research, Ligand binding (Biochemistry) -- Physiological aspects, Embryology -- Research, Autocrine mechanisms -- Research, Biological sciences
Abstract

Proper spatial localization of EGFR signaling activated by autocrine ligands represents a critical factor in embryonic development as well as tissue organization and function, and ligand/receptor binding affinity is among the molecular and cellular properties suggested to play a role in governing this localization. We employ a computational model to predict how receptor-binding affinity affects local capture of autocrine ligand vis-a-vis escape to distal regions, and provide experimental test by constructing cell lines expressing EGFR along with either wild-type EGF or a low-affinity mutant, EG[F.sup.L47M]. The model predicts local capture of a lower affinity antocrine ligand to be less efficient when the ligand production rate is small relative to receptor appearance rate. Our experimental data confirm this prediction, demonstrating that cells can use ligand/receptor binding affinity to regulate ligand spatial distribution when autocrine ligand production is limiting for receptor signaling.

Published
2002

24. 遠位尿細管傷害のラットとヒトにおける尿中calbindin1蛋白質排泄の減少について

Author

Iida, Tomoko

Subjects
Anti-GBM glomerulonephritis, nervous system, urogenital system, digestive, oral, and skin physiology, IgA nephropathy, urologic and male genital diseases, Immunohistochemistry, nervous system diseases, Real-time PCR, Western blotting
Abstract

"Background: Several proteins have been proposed as new urinary biomarkers of kidney injuries, but they are not always capable of identifying the kidney nephron segment that has been injured. Since calbindin 1 protein is exclusively localized in the kidney distal nephron segment, it is presumed that its expression is altered during distal nephron segment injuries, resulting in changes in its urinary excretion. Methods Calbindin 1 expression in normal rat kidneys was compared with that in the kidneys of rats that had suffered distal nephron segment injuries (unilateral ureteral obstruction [UUO] or anti-glomerular basement membrane glomerulonephritis [anti-GBM GN]) using immunohistochemical examinations and real-time polymerase chain reaction. The urinary calbindin 1 protein concentration of normal rats was also compared with that of anti-GBM GN rats and of cisplatin nephropathy rats using Western blotting. We also compared the kidney and urinary calbindin 1 protein concentrations of normal human subjects with those of proteinuric patients [immunoglobulin (Ig)A nephropathy; IgAN] with distal nephron segment injuries. Results: Calbindin 1 mRNA expression in the renal cortices and calbindin 1 protein expression in the kidney distal nephron segments were decreased in the UUO and anti-GBM GN rat kidneys. The urinary calbindin 1 protein levels of the anti-GBM GN rats were also markedly decreased, whereas those of the cisplatin nephropathy rats were slightly decreased. The human IgAN patients displayed decreased renal calbindin 1 protein expression in\ntheir dilated distal tubules, and some patients displayed decreased urinary calbindin 1 levels. Conclusion: Since it has been demonstrated that decreased urinary calbindin 1 levels are indicative of decreased calbindin 1 kidney expression due to distal nephron segment injuries, calbindin 1 might be a useful urinary biomarker for identifying distal nephron segment injuries.", 学位の種類: 博士（医学）. 報告番号: 甲第3986号. 学位記番号: 新大院博（医）甲第632号. 学位授与年月日: 平成27年3月23日, Clinical and Experimental Nephrology. 2014, 18(3), 432-443., 新大院博（医）甲第632号

Published
2015

26. Complementary and alternative medicine use by visitors to rural Japanese family medicine clinics: results from the international complementary and alternative medicine survey

Author

Shumer, Gregory, primary, Warber, Sara, additional, Motohara, Satoko, additional, Yajima, Ayaka, additional, Plegue, Melissa, additional, Bialko, Matthew, additional, Iida, Tomoko, additional, Sano, Kiyoshi, additional, Amenomori, Masaki, additional, Tsuda, Tsukasa, additional, and Fetters, Michael D, additional

Published
2014
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27. Erratum to: Decreased urinary calbindin 1 levels in proteinuric rats and humans with distal nephron segment injuries

Author

Iida, Tomoko, primary, Fujinaka, Hidehiko, additional, Xu, Bo, additional, Zhang, Ying, additional, Magdeldin, Sameh, additional, Nameta, Masaaki, additional, Liu, Zan, additional, Yoshida, Yutaka, additional, Yaoita, Eishin, additional, Tomizawa, Shuichi, additional, Saito, Akihiko, additional, and Yamamoto, Tadashi, additional

Published
2013
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35. 3-Benzylamino-β-carboline derivatives induce apoptosis through G2/M arrest in human carcinoma cells HeLa S-3

Author

Ikeda, Reiko, Iwaki, Toshie, Iida, Tomoko, Okabayashi, Takasumi, Nishi, Eishiro, Kurosawa, Masaki, Sakai, Norio, and Konakahara, Takeo

Subjects
*CANCER cells, *CARBOLINES, *APOPTOSIS, *ANTINEOPLASTIC agents, *BROMIDES, *HYDROXYL group, *DNA, *CELL cycle, *BIOSYNTHESIS, *MOLECULAR structure
Abstract

Abstract: β-Carboline derivatives are known as the lead compounds for anti-tumor agents. To examine an optimal structure for anti-tumor activity, we synthesized a variety of β-carboline derivatives, possessing a variety of substituents on the nitrogen atom of the amino group of 3-amino-β-carboline, and evaluated their anti-tumor activity for HeLa S-3 cell line. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that an optimal structure for anti-tumor activity was 3-cyclohexylmethylamino (1e) or 3-benzylamino-β-carboline (1f). An optimal counter anion of 2-methyl-3-benzylamino- β-carbolinium salts was a triflate anion 2c. In addition, the introduction of a hydroxyl group on the meta-position of the benzyl group of 3-benzylamino-β-carboline (3e) enhanced its anti-tumor activity. Hoechst 33342 staining and DNA fragmentation assay suggested that 1f, 2c and 3e induced cell death by apoptosis unlike 1e. Flow cytometry analysis showed that 1f, 2c and 3e induced cell apoptosis through arrest of the cell cycle in the G2/M phase. [ABSTRACT FROM AUTHOR]

Published
2011
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