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16 results on '"Igwe, Franklin"'

9. One-Year Real-World Brolucizumab Outcomes in Neovascular Age-Related Macular Degeneration from a Large US Cohort in the IRIS® Registry

Author

MacCumber, Mathew W., primary, Wykoff, Charles C., additional, Karcher, Helene, additional, Adiguzel, Eser, additional, Buxy Sinha, Samriddhi, additional, Vishwakarma, Saloni, additional, LaPrise, Andrew, additional, Igwe, Franklin, additional, Freitas, Rita, additional, Ip, Michael S., additional, and Zarbin, Marco A., additional

Published
2023
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13. Atherosclerotic coronary artery disease in a tertiary health care facility: an autopsy study

Author

Igwe, Franklin Emenike, Soyemi, Sunday Sokunle, Nwosu, Simeon, Faduyile, Francis Adedayo, and Awa, Offiah

Subjects
Coronary artery, Atherosclerosis, Ischaemic heart disease
Abstract

Background: Atherosclerotic coronary artery disease (ACAD), which manifests as ischaemic heart disease (IHD), is the single largest killer worldwide with yearly global mortality of about seven million.Objective: onsidering the rising trends of ACAD worldwide and the report that by year 2020, IHD would be the most common cause of death globally; the need for this study has become imperative.Methods: This was a prospective study carried out on 135 autopsied bodies in a tertiary hospital in South Western, Nigeria. The heart was routinely removed using the standard dissecting method. The three arteries RCA), LAD, LCx were identified. The wall and the luminal patency of these arteries were then examined, anatomically graded by visual means using a 4-point grading system. Microscopic examination was used to support the visual grading. Data was analysed using the SPSS version 18.Results: The study revealed 84 males (62.2%) and 51 females (37.8%) representing M:F of 1.6. The ages ranged from 20-83 years. The prevalence of atherosclerosis was 26.7%. Atherosclerosis was most common in the 60-69 years group (40.9%), while it is least common in the 20-29 years (6.7%). Single- and triple-vessel involvement accounted for 17.0% each while double-vessel involvement was seen in 14.1% of the subjects. Evidence of old myocardial infarction was seen in 3 male subjects (2.2%).Conclusion: Coronary atherosclerosis usually reported rare in the past is now an emerging disease even among the young. This is evidenced by the prevalence in this study. The need has therefore arisen to increase public awareness of this health issue.Keywords: Coronary artery, Atherosclerosis, Ischaemic heart disease

Published
2018

14. Anatomical and functional outcomes following switching from aflibercept to ranibizumab in neovascular age-related macular degeneration in Europe: SAFARI study

Author

Gale, Richard P, primary, Pearce, Ian, additional, Eter, Nicole, additional, Ghanchi, Faruque, additional, Holz, Frank G, additional, Schmitz-Valckenberg, Steffen, additional, Balaskas, Konstantinos, additional, Burton, Ben J L, additional, Downes, Susan M, additional, Eleftheriadis, Haralabos, additional, George, Sheena, additional, Gilmour, David, additional, Hamilton, Robin, additional, Lotery, Andrew J, additional, Patel, Nishal, additional, Prakash, Priya, additional, Santiago, Cynthia, additional, Thomas, Saju, additional, Varma, Deepali, additional, Walters, Gavin, additional, Williams, Michael, additional, Wolf, Armin, additional, Zakri, Rosina H, additional, Igwe, Franklin, additional, and Ayan, Filis, additional

Published
2019
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15. Anatomical and functional outcomes following switching from aflibercept to ranibizumab in neovascular age-related macular degeneration in Europe: SAFARI study

Author

Gale, Richard P, Pearce, Ian, Eter, Nicole, Ghanchi, Faruque, Holz, Frank G, Schmitz-Valckenberg, Steffen, Balaskas, Konstantinos, Burton, Ben J L, Downes, Susan M, Eleftheriadis, Haralabos, George, Sheena, Gilmour, David, Hamilton, Robin, Lotery, Andrew J, Patel, Nishal, Prakash, Priya, Santiago, Cynthia, Thomas, Saju, Varma, Deepali, Walters, Gavin, Williams, Michael, Wolf, Armin, Zakri, Rosina H, Igwe, Franklin, and Ayan, Filis

Abstract

Background/AimsProspective data on switching anti-vascular endothelial growth factors in patients with neovascular age-related macular degeneration (nAMD) who have previously shown no/partial response are limited. This prospective study assessed the effect of switching from aflibercept to ranibizumab on anatomical and functional outcomes in patients with persistent/recurrent disease activity.MethodsSAFARI (NCT02161575) was a 6-month, prospective, single-arm study conducted in the UK and Germany. Patients, meeting strict eligibility criteria for one of two subgroups (primary treatment failure or suboptimal treatment response), received 3 monthly intravitreal ranibizumab injections (0.5 mg). Thereafter, ranibizumab was administered pro re nata at monthly visits. The primary endpoint was change from baseline (CfB) to day 90 in central subfield retinal thickness (CSRT). Best-corrected visual acuity (BCVA) and retinal morphology parameters were assessed.ResultsOne hundred patients were enrolled (primary treatment failure, 1; suboptimal treatment response, 99). In the overall population, there was a significant CfB in median CSRT of −30.75 µm (95% CI −59.50,–20.50; p<0.0001) to day 90. Improvements were also observed in other quantitative and qualitative optical coherence tomography parameters. In Early Treatment Diabetic Retinopathy Study letters assessed by category, 55% and 59% of patients gained 0–≥15 letters versus baseline at day 90 and day 180, respectively. However, mean improvements in BCVA (CfB) to each time point were small (≤2 letters). No new safety signals were identified.ConclusionSwitching from aflibercept to ranibizumab led to a significant improvement in CSRT, with ~60% experiencing stabilised/improved BCVA. Therefore, patients with nAMD who have shown a suboptimal response to aflibercept may benefit from switching to ranibizumab.

Published
2020
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