92 results on '"Igor Khatkov"'
Search Results
2. Myelodysplastic Syndrome: Clinical Characteristics and Significance of Preclinically Detecting Biallelic Mutations in the TET2 Gene
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Anastasiia Danishevich, Anzhelika Chegodar, Natalia Bodunova, Fedor Konovalov, Maria Nefedova, Natalya Kremneva, Nizhat Kurbanov, Airat Bilyalov, Sergey Nikolaev, Igor Khatkov, and Galina Dudina
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TET2 ,myelodysplastic syndrome ,NGS ,Science - Abstract
Myelodysplastic syndrome (MDS) is a clonal disease derived from hematopoietic stem cells, characterized by ineffective hematopoiesis (resulting in peripheral blood cytopenia) and an increased risk of transformation into acute myeloid leukemia. MDS is caused by a complex combination of genetic mutations resulting in a heterogeneous genotype. Genetic studies have identified a set of aberrations that play a central role in the pathogenesis of MDS. In this article, we present a clinical case of MDS transformation into acute myeloid leukemia in the context of two cell lines exhibiting morphological, immunophenotypic, and dysmyelopoiesis markers and the presence of two heterozygous mutations in the TET2 gene.
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- 2024
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3. Extreme Tolerance of Extraocular Muscles to Diseases and Aging: Why and How?
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Angelina Titova, Sergey Nikolaev, Airat Bilyalov, Nikita Filatov, Sergei Brovkin, Dmitrii Shestakov, Igor Khatkov, Ekaterina Pismennaya, Vyacheslav Bondarev, Margarita Antyuxina, Elena Shagimardanova, Natalia Bodunova, and Oleg Gusev
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extraocular muscles ,muscular dystrophies ,muscular aging ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The extraocular muscles (EOMs) possess unique characteristics that set them apart from other skeletal muscles. These muscles, responsible for eye movements, exhibit remarkable resistance to various muscular dystrophies and aging, presenting a significant contrast to the vulnerability of skeletal muscles to these conditions. In this review, we delve into the cellular and molecular underpinnings of the distinct properties of EOMs. We explore their structural complexity, highlighting differences in fiber types, innervation patterns, and developmental origins. Notably, EOM fibers express a diverse array of myosin heavy-chain isoforms, retaining embryonic forms into adulthood. Moreover, their motor innervation is characterized by a high ratio of nerve fibers to muscle fibers and the presence of unique neuromuscular junctions. These features contribute to the specialized functions of EOMs, including rapid and precise eye movements. Understanding the mechanisms behind the resilience of EOMs to disease and aging may offer insights into potential therapeutic strategies for treating muscular dystrophies and myopathies affecting other skeletal muscles.
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- 2024
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4. The Spectrum of Germline Nucleotide Variants in Gastric Cancer Patients in the Kyrgyz Republic
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Airat Bilyalov, Sergey Nikolaev, Anastasiia Danishevich, Igor Khatkov, Komron Makhmudov, Zhainagul Isakova, Nurbek Bakirov, Ernis Omurbaev, Alena Osipova, Ramaldan Ramaldanov, Elena Shagimardanova, Andrey Kiyasov, Oleg Gusev, and Natalia Bodunova
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gastric cancer ,NGS ,hereditary cancer ,Biology (General) ,QH301-705.5 - Abstract
Gastric cancer is a major challenge in modern oncology due to its high detection rate and prevalence. While sporadic cases make up the majority of gastric cancer, hereditary gastric cancer is caused by germline mutations in several genes linked to different syndromes. Thus, identifying hereditary forms of gastric cancer is considered crucial globally. A survey study using NGS-based analysis was conducted to determine the frequency of different types of hereditary gastric cancer in the yet-unstudied Kyrgyz population. The study cohort included 113 patients with diagnosed gastric cancer from Kyrgyzstan. The age of patients was 57.6 ± 8.9. Next-generation sequencing analysis of genomic DNA was performed using a custom Roche NimbleGen enrichment panel. The results showed that 6.2% (7/113) of the patients had pathogenic or likely pathogenic genetic variants. Additionally, 3.5% (4/113) of the patients carried heterozygous pathogenic/likely pathogenic variants in high penetrance genes, such as TP53, POLD1, RET, and BRCA2. Moreover, 2.7% (3/113) of the patients carried heterozygous mutations in genes linked to autosomal recessive conditions, specifically PALB2, FANCA, and FANCD2. We have not identified any genetic variants in hereditary GC-associated genes: CDH1, STK11, SMAD4, BMPRIA, APC, MLH1, and others. Our study included patients with sporadic features of GC. The use of recognized criteria (NCCN, Gastric Cancer, Version 2.2022) would increase the number of identified genetic variants in hereditary GC-associated genes. Further research is required to determine the clinical relevance of the genetic variants identified in the current study.
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- 2023
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5. Minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer (DIPLOMA): an international randomised non-inferiority trialResearch in context
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Maarten Korrel, Leia R. Jones, Jony van Hilst, Gianpaolo Balzano, Bergthor Björnsson, Ugo Boggi, Svein Olav Bratlie, Olivier R. Busch, Giovanni Butturini, Giovanni Capretti, Riccardo Casadei, Bjørn Edwin, Anouk M.L.H. Emmen, Alessandro Esposito, Massimo Falconi, Bas Groot Koerkamp, Tobias Keck, Ruben H.J. de Kleine, Dyre B. Kleive, Arto Kokkola, Daan J. Lips, Sanne Lof, Misha D.P. Luyer, Alberto Manzoni, Ravi Marudanayagam, Matteo de Pastena, Nicolò Pecorelli, John N. Primrose, Claudio Ricci, Roberto Salvia, Per Sandström, Frederique L.I.M. Vissers, Ulrich F. Wellner, Alessandro Zerbi, Marcel G.W. Dijkgraaf, Marc G. Besselink, Mohammad Abu Hilal, Adnan Alseidi, Constanza Aquilano, Johanna Arola, Denise Bianchi, Rachel Brown, Daniela Campani, Joanne ChinAleong, Jerome Cros, Lyubomira Dimitrova, Claudio Doglioni, Safi Dokmak, Russell Dorer, Michael Doukas, Jean Michel Fabre, Giovanni Ferrari, Viacheslay Grinevich, Stefano Gobbo, Thilo Hackert, Marius van den Heuvel, Clement Huijsentruijt, Mar Iglesias, Casper Jansen, Igor Khatkov, David Kooby, Marco Lena, Claudio Luchini, Krishna Menon, Patrick Michenet, Quintus Molenaar, Anna Nedkova, Andrea Pietrabissa, Mihaela Raicu, Rushda Rajak, Branislava Rankovic, Aniko Rendek, Benjamin Riviere, Antonio Sa Cunha, Olivier Saint Marc, Patricia Sanchez Velazquez, Donatella Santini, Aldo Scarpa, Mylene Sebagh, Donald Sears, Mihir Shah, Zahir Soonawalla, Paola Spaggiari, Lars Tharun, Tore Tholfsen, Ales Tomazic, Alessandro Vanoli, Caroline Verbeke, Joanne Verheij, Moritz Von Winterfeld, Roeland de Wilde, Vincent Yip, and Yoh Zen
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Distal pancreatectomy ,Pancreatic ductal adenocarcinoma ,Minimally invasive surgery ,Public aspects of medicine ,RA1-1270 - Abstract
Summary: Background: The oncological safety of minimally invasive surgery has been questioned for several abdominal cancers. Concerns also exist regarding the use of minimally invasive distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer as randomised trials are lacking. Methods: In this international randomised non-inferiority trial, we recruited adults with resectable pancreatic cancer from 35 centres in 12 countries. Patients were randomly assigned to either MIDP (laparoscopic or robotic) or open distal pancreatectomy (ODP). Both patients and pathologists were blinded to the assigned approach. Primary endpoint was radical resection (R0, ≥1 mm free margin) in patients who had ultimately undergone resection. Analyses for the primary endpoint were by modified intention-to-treat, excluding patients with missing data on primary endpoint. The pre-defined non-inferiority margin of −7% was compared with the lower limit of the two-sided 90% confidence interval (CI) of absolute difference in the primary endpoint. This trial is registered with the ISRCTN registry (ISRCTN44897265). Findings: Between May 8, 2018 and May 7, 2021, 258 patients were randomly assigned to MIDP (131 patients) or ODP (127 patients). Modified intention-to-treat analysis included 114 patients in the MIDP group and 110 patients in the ODP group. An R0 resection occurred in 83 (73%) patients in the MIDP group and in 76 (69%) patients in the ODP group (difference 3.7%, 90% CI −6.2 to 13.6%; pnon-inferiority = 0.039). Median lymph node yield was comparable (22.0 [16.0–30.0] vs 23.0 [14.0–32.0] nodes, p = 0.86), as was the rate of intraperitoneal recurrence (41% vs 38%, p = 0.45). Median follow-up was 23.5 (interquartile range 17.0–30.0) months. Other postoperative outcomes were comparable, including median time to functional recovery (5 [95% CI 4.5–5.5] vs 5 [95% CI 4.7–5.3] days; p = 0.22) and overall survival (HR 0.99, 95% CI 0.67–1.46, p = 0.94). Serious adverse events were reported in 23 (18%) of 131 patients in the MIDP group vs 28 (22%) of 127 patients in the ODP group. Interpretation: This trial provides evidence on the non-inferiority of MIDP compared to ODP regarding radical resection rates in patients with resectable pancreatic cancer. The present findings support the applicability of minimally invasive surgery in patients with resectable left-sided pancreatic cancer. Funding: Medtronic Covidien AG, Johnson & Johnson Medical Limited, Dutch Gastroenterology Society.
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- 2023
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6. CDKN2A Gene Mutations: Implications for Hereditary Cancer Syndromes
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Anastasiia Danishevich, Airat Bilyalov, Sergey Nikolaev, Nodirbec Khalikov, Daria Isaeva, Yuliya Levina, Maria Makarova, Marina Nemtsova, Denis Chernevskiy, Olesya Sagaydak, Elena Baranova, Maria Vorontsova, Mariya Byakhova, Anna Semenova, Vsevolod Galkin, Igor Khatkov, Saida Gadzhieva, and Natalia Bodunova
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CDKN2A ,melanoma ,pancreatic cancer ,Biology (General) ,QH301-705.5 - Abstract
Malignant neoplasms, including pancreatic cancer and melanoma, are major global health challenges. This study investigates melanoma pancreatic syndrome, a rare hereditary tumor syndrome associated with CDKN2A gene mutations. CDKN2A mutations contribute to a lifetime risk of melanoma ranging from 28% to 67%. This study reports the clinical features of six individuals with CDKN2A mutations and identifies recurrent alterations such as c.307_308del, c.159G>C and c.71G>C. It highlights the need for CDKN2A mutation testing in suspected cases of familial atypical multiple mole melanoma. Clinically significant variants show associations with melanoma and pancreatic cancer. The challenges of treating individuals with CDKN2A mutations are discussed, and the lack of specific targeted therapies is highlighted. Preclinical studies suggest a potential benefit of CDK4/6 inhibitors, although clinical trials show mixed results. This study underscores the importance of continued research into improved diagnostic and therapeutic strategies to address the complexities of hereditary cancer syndromes.
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- 2023
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7. Minimally invasive versus open distal pancreatectomy for pancreatic ductal adenocarcinoma (DIPLOMA): study protocol for a randomized controlled trial
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Jony van Hilst, Maarten Korrel, Sanne Lof, Thijs de Rooij, Frederique Vissers, Bilal Al-Sarireh, Adnan Alseidi, Adrian C. Bateman, Bergthor Björnsson, Ugo Boggi, Svein Olav Bratlie, Olivier Busch, Giovanni Butturini, Riccardo Casadei, Frederike Dijk, Safi Dokmak, Bjorn Edwin, Casper van Eijck, Alessandro Esposito, Jean-Michel Fabre, Massimo Falconi, Giovanni Ferrari, David Fuks, Bas Groot Koerkamp, Thilo Hackert, Tobias Keck, Igor Khatkov, Ruben de Kleine, Arto Kokkola, David A. Kooby, Daan Lips, Misha Luyer, Ravi Marudanayagam, Krishna Menon, Quintus Molenaar, Matteo de Pastena, Andrea Pietrabissa, Rushda Rajak, Edoardo Rosso, Patricia Sanchez Velazquez, Olivier Saint Marc, Mihir Shah, Zahir Soonawalla, Ales Tomazic, Caroline Verbeke, Joanne Verheij, Steven White, Hanneke W. Wilmink, Alessandro Zerbi, Marcel G. Dijkgraaf, Marc G. Besselink, Mohammad Abu Hilal, and for the European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)
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Minimally invasive ,Laparoscopic ,Robot-assisted ,Distal pancreatectomy ,Left pancreatectomy ,Pancreatic tail resection ,Medicine (General) ,R5-920 - Abstract
Abstract Background Recently, the first randomized trials comparing minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) for non-malignant and malignant disease showed a 2-day reduction in time to functional recovery after MIDP. However, for pancreatic ductal adenocarcinoma (PDAC), concerns have been raised regarding the oncologic safety (i.e., radical resection, lymph node retrieval, and survival) of MIDP, as compared to ODP. Therefore, a randomized controlled trial comparing MIDP and ODP in PDAC regarding oncological safety is warranted. We hypothesize that the microscopically radical resection (R0) rate is non-inferior for MIDP, as compared to ODP. Methods/design DIPLOMA is an international randomized controlled, patient- and pathologist-blinded, non-inferiority trial performed in 38 pancreatic centers in Europe and the USA. A total of 258 patients with an indication for elective distal pancreatectomy with splenectomy because of proven or highly suspected PDAC of the pancreatic body or tail will be randomly allocated to MIDP (laparoscopic or robot-assisted) or ODP in a 1:1 ratio. The primary outcome is the microscopically radical resection margin (R0, distance tumor to pancreatic transection and posterior margin ≥ 1 mm), which is assessed using a standardized histopathology assessment protocol. The sample size is calculated with the following assumptions: 5% one-sided significance level (α), 80% power (1-β), expected R0 rate in the open group of 58%, expected R0 resection rate in the minimally invasive group of 67%, and a non-inferiority margin of 7%. Secondary outcomes include time to functional recovery, operative outcomes (e.g., blood loss, operative time, and conversion to open surgery), other histopathology findings (e.g., lymph node retrieval, perineural- and lymphovascular invasion), postoperative outcomes (e.g., clinically relevant complications, hospital stay, and administration of adjuvant treatment), time and site of disease recurrence, survival, quality of life, and costs. Follow-up will be performed at the outpatient clinic after 6, 12, 18, 24, and 36 months postoperatively. Discussion The DIPLOMA trial is designed to investigate the non-inferiority of MIDP versus ODP regarding the microscopically radical resection rate of PDAC in an international setting. Trial registration ISRCTN registry ISRCTN44897265 . Prospectively registered on 16 April 2018.
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- 2021
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8. Helicobacter pylori Antibiotic Resistance: Molecular Basis and Diagnostic Methods
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Irina Medakina, Larisa Tsapkova, Vera Polyakova, Sergey Nikolaev, Tatyana Yanova, Natalia Dekhnich, Igor Khatkov, Dmitry Bordin, and Natalia Bodunova
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Helicobacter pylori ,antibiotic resistance ,methods for determining H. pylori resistance ,molecular genetic diagnostics ,phenotypic methods for determining antibiotic resistance ,geographical distribution of H. pylori antibiotic resistance ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Helicobacter pylori is one of the most common cause of human infections. Infected patients develop chronic active gastritis in all cases, which can lead to peptic ulcer, atrophic gastritis, gastric cancer and gastric MALT-lymphoma. The prevalence of H. pylori infection in the population has regional characteristics and can reach 80%. Constantly increasing antibiotic resistance of H. pylori is a major cause of treatment failure and a major problem. According to the VI Maastricht Consensus, two main strategies for choosing eradication therapy are recommended: individualized based on evaluating sensitivity to antibacterial drugs (phenotypic or molecular genetic method) prior to their appointment, and empirical, which takes into account data on local H. pylori resistance to clarithromycin and monitoring effectiveness schemes in the region. Therefore, the determination of H. pylori resistance to antibiotics, especially clarithromycin, prior to choosing therapeutic strategy is extremely important for the implementation of these treatment regimens.
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- 2023
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9. The CFTR Gene Germline Heterozygous Pathogenic Variants in Russian Patients with Malignant Neoplasms and Healthy Carriers: 11,800 WGS Results
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Maria Makarova, Marina Nemtsova, Anastasiia Danishevich, Denis Chernevskiy, Maxim Belenikin, Anastasiia Krinitsina, Elena Baranova, Olesya Sagaydak, Maria Vorontsova, Igor Khatkov, Lyudmila Zhukova, Natalia Bodunova, Sergey Nikolaev, Mariya Byakhova, Anna Semenova, Vsevolod Galkin, and Saida Gadzhieva
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cystic fibrosis ,CFTR ,hereditary cancer predisposition syndrome ,the frequency of heterozygous carriage ,Russian cohort of patients ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
More than 275 million people in the world are carriers of a heterozygous mutation of the CFTR gene, associated with cystic fibrosis, the most common autosomal recessive disease among Caucasians. Some recent studies assessed the association between carriers of CFTR variants and some pathologies, including cancer risk. The aim of this study is to analyze the landscape of germline pathogenic heterozygous CFTR variants in patients with diagnosed malignant neoplasms. For the first time in Russia, we evaluated the frequency of CFTR pathogenic variants by whole-genome sequencing in 1800 patients with cancer and compared this with frequencies of CFTR variants in the control group (1825 people) adjusted for age and 10,000 healthy individuals. In the issue, 47 out of 1800 patients (2.6%) were carriers of CFTR pathogenic genetic variants: 0.028 (42/1525) (2.8%) among breast cancer patients, 0.017 (3/181) (1.7%) among colorectal cancer patients and 0.021 (2/94) (2.1%) among ovarian cancer patients. Pathogenic CFTR variants were found in 52/1825 cases (2.85%) in the control group and 221 (2.21%) in 10,000 healthy individuals. Based on the results of the comparison, there was no significant difference in the frequency and distribution of pathogenic variants of the CFTR gene, which is probably due to the study limitations. Obviously, additional studies are needed to assess the clinical significance of the heterozygous carriage of CFTR pathogenic variants in the development of various pathologies in the future, particularly cancer.
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- 2023
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10. Application of Multigene Panels Testing for Hereditary Cancer Syndromes
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Airat Bilyalov, Sergey Nikolaev, Leila Shigapova, Igor Khatkov, Anastasia Danishevich, Ludmila Zhukova, Sergei Smolin, Marina Titova, Tatyana Lisica, Natalia Bodunova, Elena Shagimardanova, and Oleg Gusev
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hereditary cancer ,multigene panels ,NGS ,Biology (General) ,QH301-705.5 - Abstract
Background: Approximately 5–10% of all cancers are associated with hereditary cancer predisposition syndromes (HCPS). Early identification of HCPS is facilitated by widespread use of next-generation sequencing (NGS) and brings significant benefits to both the patient and their relatives. This study aims to evaluate the landscape of genetic variants in patients with personal and/or family history of cancer using NGS-based multigene panel testing. Materials and Methods: The study cohort included 1117 probands from Russia: 1060 (94.9%) patients with clinical signs of HCPS and 57 (5.1%) healthy individuals with family history of cancer. NGS analysis of 76 HCPS genes was performed using a custom Roche NimbleGen enrichment panel. Results: Pathogenic/likely pathogenic variants were identified in 378 of 1117 individuals (33.8%). The predominant number (59.8%) of genetic variants was identified in BRCA1/BRCA2 genes. CHEK2 was the second most commonly altered gene with a total of 28 (7.4%) variants, and 124 (32.8%) genetic variants were found in other 35 cancer-associated genes with variable penetrance. Conclusions: Multigene panel testing allows for a differential diagnosis and identification of high-risk group for oncological diseases. Our results demonstrate that inclusion of non-coding gene regions into HCPS gene panels is highly important for the identification of rare spliceogenic variants with high penetrance.
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- 2022
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11. A Unique Observation of a Patient with Vulto-van Silfhout-de Vries Syndrome
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Natalia Bodunova, Maria Vorontsova, Igor Khatkov, Elena Baranova, Svetlana Bykova, Daniil Degterev, Maria Litvinova, Airat Bilyalov, Maria Makarova, Olesya Sagaydak, and Anastasia Danishevich
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VULTO-VAN syndrome ,DEAF1 ,VSVS ,Medicine (General) ,R5-920 - Abstract
Introduction: Vulto-van Silfhout-de Vries Syndrome (VSVS; OMIM#615828) is a rare hereditary disease associated with impaired intellectual development and speech, delayed psychomotor development, and behavioral anomalies, including autistic behavioral traits and poor eye contact. To date, 27 patients with VSVS have been reported in the literature. Materials and Methods: We describe a 23-year-old male patient with autism spectrum disorder (ASD) who was admitted to the gastroenterological hospital with signs of pseudomembranous colitis. ASD was first noted in the patient at the age of 2.5 years. Later, he developed epileptic seizures and important growth retardation. Prior to the hospitalization, chromosomal aberrations, Fragile X syndrome, and aminoacidopathies/aminoacidurias associated with ASD were excluded. Whole-genome sequencing (WGS) was prescribed to the patient at 23 years old. Results: The patient had a heterozygous carrier of “de novo” variant c.662C > T (p.S221L) in exon 4 of the DEAF1 gene. c.662C > T had not been previously described in genomic databases. According to the ACMG criteria, this missense variant was considered to be pathogenic. VSVS was diagnosed in the patient. Conclusions: The phenotype of the patient is very similar to the data presented in the world literature. However, growth retardation and cachexia, which have not been described previously in the articles, are of interest.
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- 2022
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12. Robotic rectal resection: preliminary Russian experience
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Igor Khatkov, Stepan Pozdnyakov, Andrey Atroshchenko, Mikhail Danilov, Sergey Chudnikh, Zaira Abdulatipova, Igor Dolgopyatov, Georgi Saakjan, Yuri Streltsov, and Vladimir Yegorov
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Purpose: To outline the preliminary experience of the da Vinci® robotic system used in a Moscow tertiary colorectal referral center for an unselected range of benign and malignant rectal conditions. Methods: Prospective non-randomized single-center study which analyzed results of 26 robotic rectal resections performed between january 2014 and december 2016. Results: The cohort included 10 females and 16 males (mean total age 61.6 years). Three patients underwent surgery for benign rectal villous adenomas. The median overall ASA score was 4 (ranged from 2 to 5). Of the surgeries, there were 19 total mesorectal excisions with 6 patients undergoing a multivisceral resection. The mean operating time was 358 minutes with a mean blood loss of 203 mL. All total mesorectal excision specimens were adjudged according Philip Quirke classification as mesorectal plane – Grade 3 with a mean of 18.5 lymph nodes identified (from 12 to 35). Of these there were 10 patients (38.5%) with lymph node metastases. After surgery the average pain score was 2.1 out of 10 on the “Visual-Analogue Pain Intensity Scale” and 1.5 score out of 10 on the “Brief Pain Inventory with Quality of Life”. Anal continency after rectal resection with total mesorectal excisions estimated according Wexner Scale: 10 days after surgery average score was −3.1 and a 6 month after surgery −1.6 score. The median length of hospital stay was 11 days (from 10 to 15). Conclusion: Our initial experience with a totally robotic rectal resection has shown the technique to be safe and feasible, particularly in patients where conventional laparoscopic rectal resection would be anticipated to be challenging. Resumo: Objetivo: Delinear a experiência preliminar do sistema robótico da Vinci® usado em um centro de referência colorretal terciário de Moscou para uma gama não selecionada de problemas retais benignos e malignos. Métodos: Estudo unicêntrico prospectivo não randomizado que analisou os resultados de 26 ressecções retais robóticas realizadas entre janeiro de 2014 e dezembro de 2016. Resultados: A coorte incluiu 10 mulheres e 16 homens (idade total média de 61,6 anos). Três pacientes foram submetidos à cirurgia para adenomas vilosos retais benignos. O escore global mediano da ASA foi de 4 (variou de 2 a 5). Das cirurgias, houve 19 excisões mesorretais totais com 6 pacientes submetidos à ressecção multivisceral. O tempo médio de cirurgia foi de 358 minutos, com perda sanguínea média de 203 mL. Todas as amostras de excisão total do mesorreto foram classificadas de acordo com a classificação de Philip Quirke como plano mesorretal - Grau 3 com uma média de 18,5 linfonodos identificados (de 12 a 35). Destes, havia 10 pacientes (38,5%) com metástases linfonodais. Após a cirurgia, o escore médio de dor foi de 2,1 de 10 na Escala de Intensidade da Dor Visual-Analógica e de 1,5 de 10 no “Inventário Breve de Dor com Qualidade de Vida”. Continência anal após ressecção retal com excisões totais mesorretais estimadas de acordo com a Escala de Wexner: 10 dias após a cirurgia o escore médio foi -3,1 e um escore de -1,6 após 6 meses da cirurgia. A mediana do tempo de internação foi de 11 dias (de 10 a 15). Conclusão: Nossa experiência inicial com uma ressecção retal totalmente robótica mostrou que a técnica é segura e viável, particularmente em pacientes nos quais a ressecção retal laparoscópica convencional seria prevista como um desafio. Keywords: Robotic surgery, Rectal cancer, Colorectal surgery, Palavras-chave: Cirurgia robótica, Câncer retal, Cirurgia colorretal
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- 2018
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13. Laparoscopic cytoreductive surgery for metastatic colon cancer – how to improve treatment strategy
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Andrey Atroshchenko, Igor Khatkov, Stepan Pozdnyakov, and Mikhail Danilov
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Colon cancer (CC) one of the most common oncological disease in World. Up to 30% patients in Russia have metastatic CC at first visiting to oncologist. The treatment results still controversial. Nowadays, minimally invasive laparoscopic precision technique allowed extending the indication for cytoreductive surgery even in patients with severe comorbidities. Materials and methods: 89 patients with colon cancer (T1-4a) and curable synchronous distant metastases include in study. All patients underwent cytoreductive surgery with primary tumor resection. In study group (44) we performed laparoscopic surgery, in main group (45) – open surgery procedure. The groups were similar by sex, age, tumor localization and histological structure, comorbidities. Results: R0 resection performed 27% patients. The average number of lymph node removal was similar 13 and 12 respectively. Average operation time was significantly longer in study group 210 vs 120 min. In study group blood loss was lower: 300 mL vs 1200 mL. Postoperative patient recovery shorter after laparoscopic surgery (p
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- 2017
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14. Pancreatic Hydatid Cyst Misdiagnosed as Mucinous Cystadenoma: CT and MRI Findings
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Milica Mitrovic, Boris Tadic, Jelena Kovac, Nikola Grubor, Vladimir Milosavljevic, Aleksandra Jankovic, Igor Khatkov, Dejan Radenkovic, and Slavko Matic
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hydatid cyst ,echinococcus granulosus ,pancreas ,laparoscopy ,pancreatic cyst ,imaging ,distal pancreatectomy ,Medicine (General) ,R5-920 - Abstract
Isolated hydatid cysts of the pancreas are rare lesions, even in endemic regions. In this report, we present the case of a 76-year-old patient who was admitted to our clinic with a diagnosis of a cystic lesion in the tail of the pancreas. On preoperative computed tomography (CT) and magnetic resonance (MR) examination, the cyst was characterized as a mucinous cystadenoma. A laparoscopic distal pancreatectomy followed. A histopathological examination revealed a large hydatid cyst in the tail of the pancreas.
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- 2020
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15. Genetic Determinants of Autoimmune Gastritis
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Vera Polyakova, Natalia Bodunova, Konstantin Rumyantsev, Igor Khatkov, Dmitry Bordin, Airat Bilyalov, Philipp Sviridov, and Tatiana Yanova
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Biomedical Engineering ,Bioengineering - Published
- 2023
16. Laparoscopic versus open Frey procedure: Comparative analysis of short and long-term outcomes
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Igor Khatkov, Roman Izrailov, Victor Tsvirkun, Ruslan Alikhanov, Oleg Vasnev, Tatiana Dyuzheva, Viacheslav Egorov, Kamil Dalgatov, Magomet Baychorov, Paul Agami, and Aleksey Andrianov
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Hepatology ,Endocrinology, Diabetes and Metabolism ,Gastroenterology - Published
- 2022
17. Figures do matter: A literature review of 4587 robotic pancreatic resections and their implications on training
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Giovanni B, Levi Sandri, Mohammed, Abu Hilal, Safi, Dokmak, Bjørn, Edwin, Thilo, Hackert, Tobias, Keck, Igor, Khatkov, Marc G, Besselink, Ugo, Boggi, and Emir, Hoti
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learning curve ,pancreatoduodenectomy ,Hepatology ,robotic surgery ,minimally invasive ,distal pancreatectomy ,total pancreatectomy ,Surgery ,pancreas ,central pancreatectomy ,enucleation - Abstract
Background: The use of robotic assistance in minimally invasive pancreatic resection is quickly growing. Methods: We present a systematic review of the literature regarding all types of robotic pancreatic resection (RPR). Our aim is to show for which procedures there is enough experience to permit safe training and provide an estimation of how many centers could serve as teaching institutions. Results: Sixty-four studies reporting on 4587 RPRs were analyzed. A total of 2598 pancreatoduodenectomies (PD) were reported by 28 centers from Europe (6/28; 21.4%), the Americas (11/28; 39.3%), and Asia (11/28; 39.3%). Six studies reported >100 robot PD (1694/2598; 65.2%). A total of 1618 distal pancreatectomies (DP) were reported by 29 centers from Europe (10/29; 34.5%), the Americas (10/29; 34.5%), and Asia (9/29; 31%). Five studies reported >100 robotic DP (748/1618; 46.2%). A total of 154 central pancreatectomies were reported by six centers from Europe (1/6; 16.7%), the Americas (2/6; 33.3%), and Asia (3/6; 50%). Only 49 total pancreatectomies were reported. Finally, 168 enucleations were reported in seven studies (with a mean of 15.4 cases per study). A single center reported on 60 enucleations (35.7%). Results of each type of robotic procedure are also presented. Conclusions: Experience with RPR is still quite limited. Despite high case volume not being sufficient to warrant optimal training opportunities, it is certainly a key component of every successful training program and is a major criterion for fellowship accreditation. From this review, it appears that only PD and DP can currently be taught at few institutions worldwide.
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- 2022
18. A core set of quality performance indicators for HPB procedures: a global consensus for hepatectomy, pancreatectomy, and complex biliary surgery
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Braden Woodhouse, Savio G. Barreto, Kjetil Soreide, Gregor A. Stavrou, Catherine Teh, Henry Pitt, Marcello Di Martino, Paulo Herman, Victor Lopez-Lopez, Frederik Berrevoet, Mark Talamonti, Mikhail Mikhnevich, Igor Khatkov, Laurence Webber, Ayrat Kaldarov, John Windsor, Omero P. Costa Filho, and Jonathan Koea
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Hepatology ,Gastroenterology - Published
- 2023
19. Outcomes After Minimally Invasive Versus Open Total Pancreatectomy: A Pan-European Propensity Score Matched Study
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Carlo Lombardo, Mohammed Abu Hilal, Tobias Keck, Igor Khatkov, P. Tyutyunnik, David Fuks, Lianne Scholten, Niccolò Napoli, Alberto Manzoni, Gianpaolo Balzano, Sjors Klompmaker, Jony van Hilst, Fernando Burdío, Edoardo Rosso, Giovanni Ferrari, Riccardo Casadei, Mario Annecchiarico, Mustafa Kerem, Massimo Falconi, Marc G. Besselink, Jean-Michel Fabre, Ulrich F. Wellner, Michele Mazzola, Ugo Boggi, Surgery, CCA - Cancer Treatment and Quality of Life, CCA - Imaging and biomarkers, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Scholten, Lianne, Klompmaker, Sjor, Van Hilst, Jony, Annecchiarico, Mario M, Balzano, Gianpaolo, Casadei, Riccardo, Fabre, Jean-Michel, Falconi, Massimo, Ferrari, Giovanni, Kerem, Mustafa, Khatkov, Igor E, Lombardo, Carlo, Manzoni, Alberto, Mazzola, Michele, Napoli, Niccolò, Rosso, Edoardo E, Tyutyunnik, Pavel, Wellner, Ulrich F, Fuks, David, Burdio, Fernando, Keck, Tobia, Hilal, Mohammed Abu, Besselink, Marc G, and Boggi, Ugo
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medicine.medical_specialty ,robot-assisted surgery ,Adult patients ,propensity score matching ,business.industry ,Total pancreatectomy ,laparoscopic surgery ,Pancreatic surgery ,Primary outcome ,Pan european ,Internal medicine ,Propensity score matching ,total pancreatectomy, minimally invasive surgery, laparoscopic surgery, robot-assisted surgery, pancreatic surgery, propensity score matching ,Overall survival ,Medicine ,Surgery ,total pancreatectomy ,pancreatic surgery ,business ,Hospital stay ,minimally invasive surgery - Abstract
© 2022 Wolters Kluwer Health, Inc. All rights reserved.Objective: To assess postoperative 90-day outcomes after minimally invasive (laparoscopic/robot-assisted) total pancreatectomy (MITP) in selected patients versus open total pancreatectomy (OTP) among European centers. Background: Minimally invasive pancreatic surgery is becoming increasingly popular but data on MITP are scarce and multicenter studies comparing outcomes versus OTP are lacking. It therefore remains unclear if MITP is a valid alternative. Methods: Multicenter retrospective propensity-score matched study including consecutive adult patients undergoing MITP or OTP for all indications at 16 European centers in 7 countries (2008-2017). Patients after MITP were matched (1:1, caliper 0.02) to OTP controls. Missing data were imputed. The primary outcome was 90-day major morbidity (Clavien-Dindo ≥3a). Secondary outcomes included 90-day mortality, length of hospital stay, and survival. Results: Of 361 patients (99MITP/262 OTP), 70 MITP procedures (50 laparoscopic, 15 robotic, 5 hybrid) could be matched to 70 OTP controls. After matching, MITP was associated with a lower rate of major morbidity (17% MITP vs. 31% OTP, P = 0.022). The 90-day mortality (1.4% MITP vs. 7.1% OTP, P = 0.209) and median hospital stay (17 [IQR 11-24] MITP vs. 12 [10-23] days OTP, P = 0.876) did not differ significantly. Among 81 patients with PDAC, overall survival was 3.7 (IQR 1.7-N/A) versus 0.9 (IQR 0.5-N/ A) years, for MITP versus OTP, which was nonsignificant after stratification by T-stage. Conclusion: This international propensity score matched study showed that MITP may be a valuable alternative to OTP in selected patients, given the associated lower rate of major morbidity.
- Published
- 2023
20. Learning curve of three European centers in laparoscopic, hybrid laparoscopic, and robotic pancreatoduodenectomy
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Tobias Keck, Magomet Baychorov, P. Tyutyunnik, Ugo Boggi, Hryhoriy Lapshyn, Francesca Menonna, Ulrich F. Wellner, Sjors Klompmaker, Mark G. Besselink, Abe Fingerhut, Igor Khatkov, Moh'd Abu Hilal, Carlo Lombardo, Roman Izrailov, Niccolò Napoli, Surgery, CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
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Laparoscopic surgery ,medicine.medical_specialty ,medicine.medical_treatment ,Operative Time ,CUSUM ,Laparoscopic-assisted surgery ,Learning curve ,Minimally invasive surgery ,Pancreatectomy ,Pancreatoduodenectomy ,Robot-assisted surgery ,Humans ,Learning Curve ,Pancreaticoduodenectomy ,Postoperative Complications ,Retrospective Studies ,Laparoscopy ,Robotic Surgical Procedures ,030230 surgery ,03 medical and health sciences ,0302 clinical medicine ,Blood loss ,medicine ,Gastric emptying ,business.industry ,Retrospective cohort study ,Surgery ,Cohort ,030211 gastroenterology & hepatology ,business ,Abdominal surgery - Abstract
Introduction: There are limited numbers of high-volume centers performing minimally invasive pancreatoduodenectomy (MIPD) routinely. Several approaches to MIPD have been described. Aim of this analysis was to show the learning curve of three different approaches to MIPD. Focus was on determining the number of cases necessary to obtain proficient level in MIPD. Patients and methods: Retrospective study wherein outcomes of 300 consecutive patients at three centers—at each center the initial 100 consecutive patients undergoing MIPD for malignant and benign tumors of the head of the pancreas and perimpullary area, performed by three experienced surgeons were collected and analyzed. Results: Overall, 300 patients after MIPD were included: the three different cohorts (laparoscopic n = 100, hybrid n = 100, robotic n = 100). CUSUM analysis of operating time in each center demonstrated that the plateau for laparoscopic PD was n = 61, for hybrid PDes was n = 32 and for robotic PD was n = 68. Median operative time for laparoscopic, hybrid, and robotic approaches was 395 min, 404 min, 510 min, respectively. Intraoperative blood loss for laparoscopic PD, hybrid PD, and robotic PD was 250 ml, 250 ml, and 413 ml, respectively. Delayed gastric emptying occurred 12% in laparoscopic cohort, 10% in hybrid, and 53% in robotic cohort. Major complications (Clavien-Dindo III/IV) rate for laparoscopic PD, hybrid PD, and robotic PD was 32%, 37%, and 22% with 5% death in each cohorts, respectively. Conclusion: This analysis of the learning curve of three European centers found a shorter learning curve with hybrid PD as compared to laparoscopic and robotic PD. In implementation of a MIPD program, a stepwise approach might be beneficial.
- Published
- 2022
21. Chronic intestinal pseudoobstruction: difficulties in diagnosis and treatment. Case report
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Viktor Tsvirkun, Igor Khatkov, A I Parfenov, Daniil A. Degterev, S V Bykova, Elena V. Novikova, Kirill Shishin, Zoia P. Lashchenkova, L M Krums, O V Akhmadullina, Sergei G. Khomeriki, Valerii V. Subbotin, and Tatiana N. Kuzmina
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Adult ,History ,Pediatrics ,medicine.medical_specialty ,Malabsorption ,malabsorption ,Colon ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Antibiotics ,parenteral nutrition ,law.invention ,Young Adult ,bacterial overgrowth syndrome ,law ,prokinetics ,chronic intestinal pseudoobstruction ,Humans ,Medicine ,business.industry ,Intestinal Pseudo-Obstruction ,intestinal decompression ,General Medicine ,colon malrotation ,medicine.disease ,Intensive care unit ,Intestinal decompression ,Anti-Bacterial Agents ,Chronic intestinal pseudoobstruction ,Transplantation ,Parenteral nutrition ,Chronic Disease ,neuromyopathy ,SMALL BOWEL BACTERIAL OVERGROWTH ,Blind Loop Syndrome ,Family Practice ,business - Abstract
The article presents a clinical case of a 23-year-old patient with an extremely severe congenital form of chronic intestinal pseudoobstruction coupled with a neuromyopathy,colon malrotation, malabsorption, bacterial overgrowth syndrome, cholelithiasis and gastrostasis, which excluded bowel transplantation. Long-term treatment in the intensive care unit with combined, mainly parenteral nutrition for 6 months, using antibiotics, prokinetics, intestinal decompression allowed to achieve partial stabilization of the patients condition and transfer to home treatment with the continuation of adequate complex therapy.Представлено клиническое наблюдение больной 23 лет с крайне тяжелой врожденной формой хронической интестинальной псевдообструкции с нейромиопатией. мальротацией толстой кишки, мальабсорбцией, синдромом избыточного бактериального роста, холелитиазом, гастростазом, исключавшим выполнение трансплантации кишечника. Длительное лечение в отделении интенсивной терапии с комбинированным, преимущественно парентеральным питанием в течение 6 мес, применением антибиотиков, прокинетиков, кишечной декомпрессии позволило добиться частичной стабилизации состояния и перевода пациентки на домашнее лечение с продолжением адекватной комплексной терапии.
- Published
- 2021
22. Designing the European registry on minimally invasive pancreatic surgery: a pan-European survey
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Nicky van der Heijde, Bjørn Edwin, Ugo Boggi, Thilo Hackert, F. Vissers, Safi Dokmak, Tobias Keck, Mohammed Abu Hilal, Marc G. Besselink, Igor Khatkov, Graduate School, Surgery, CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
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medicine.medical_specialty ,MEDLINE ,Computer-assisted web interviewing ,030230 surgery ,Pancreaticoduodenectomy ,Pancreatic surgery ,03 medical and health sciences ,Patient safety ,Pancreatectomy ,0302 clinical medicine ,Pan european ,Surveys and Questionnaires ,medicine ,Humans ,Minimally Invasive Surgical Procedures ,Registries ,Pancreas ,Hepatology ,business.industry ,General surgery ,Gastroenterology ,Design phase ,030220 oncology & carcinogenesis ,Laparoscopy ,National registry ,business ,Distal pancreatectomy - Abstract
Background The recent Miami international evidence-based guidelines on minimally invasive pancreatic surgery (MIPS) advise all centers that perform MIPS to participate in multicenter registries to safeguard optimal outcomes and patient safety. During the design phase of a pan-European registry on MIPS, the European consortium of Minimally Invasive Pancreatic Surgery (E-MIPS) sought input from European HPB surgeons. Methods An anonymous online questionnaire with 23 questions on MIPS practice was sent to all member centers of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA) and E-MIPS. Results Completed questionnaires were obtained from 98 centers in 23 countries, of which 75 (76.5%) were academic centers. Centers had a median annual pancreatoduodenectomy volume of 45. The most-performed MIPS procedure was laparoscopic distal pancreatectomy (93.9% of centers). Minimally invasive pancreatoduodenectomy was performed in 49% of all centers. Some 25 centers already participated in an ongoing national registry, and were willing to share their data with the European registry on MIPS. The most mentioned (45.4%) maximum time for processing one patient's data into the registry was 10–15 min. Conclusion This European survey showed considerable support for the European registry on MIPS.
- Published
- 2021
23. Standards for reporting on surgery for chronic pancreatitis: a report from the International Study Group for Pancreatic Surgery (ISGPS)
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Markus W. Büchler, Catherine Morgan, Kevin C. Conlon, Keith D. Lillemoe, John P. Neoptolemos, Massimo Falconi, Helmut Friess, Carlos Fernandez-del Castillo, Dejan Radenkovic, Nicholas J. Zyromski, Martin Smith, S. Burmeister, Claudio Bassi, Richard D. Schulick, Santhalingam Jegatheeswaran, Marc G. Besselink, Ajith K. Siriwardena, Hjalmar C. van Santvoort, Shailesh V. Shrikhande, John A. Windsor, Jakob R. Izbicki, Luca Gianotti, Christos Dervenis, Giovanni Marchegiani, Roland Andersson, Attila Oláh, Minas Baltatzis, J. Devar, Marco Del Chiaro, Mustapha Adham, Igor Khatkov, Olivier R. Busch, Thilo Hackert, David B. Adams, Giuseppe Garcea, Andrew Smith, Charles M. Vollmer, Ioannis Passas, Surgery, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, Siriwardena, A, Windsor, J, Zyromski, N, Marchegiani, G, Radenkovic, D, Morgan, C, Passas, I, Olah, A, Conlon, K, Smith, M, Busch, O, Baltatzis, M, Besselink, M, Vollmer, C, Castillo, C, Friess, H, Garcea, G, Burmeister, S, Hackert, T, Lillemoe, K, Schulick, R, Shrikhande, S, Smith, A, Gianotti, L, Falconi, M, Adams, D, Adham, M, Andersson, R, Del Chiaro, M, Devar, J, Jegatheeswaran, S, van Santvoort, H, Khatkov, I, Izbicki, J, Buchler, M, Neoptolemos, J, Bassi, C, and Dervenis, C
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medicine.medical_specialty ,Outcome Assessment ,medicine.medical_treatment ,education ,MEDLINE ,Disease ,030230 surgery ,Outcome assessment ,Pancreatic surgery ,Pancreaticoduodenectomy ,03 medical and health sciences ,0302 clinical medicine ,Pancreatitis, Chronic ,Pancreaticojejunostomy ,Outcome Assessment, Health Care ,medicine ,Humans ,Chronic ,Pancreas ,Project group ,business.industry ,medicine.disease ,3. Good health ,Surgery ,Health Care ,medicine.anatomical_structure ,Pancreatitis ,030220 oncology & carcinogenesis ,business - Abstract
Background: The International Study Group for Pancreatic Surgery provides globally accepted definitions for reporting of complications after pancreatic surgery. This International Study Group for Pancreatic Surgery project aims to provide a standardized framework for reporting of the results of operative treatment for chronic pancreatitis. Methods: An International Study Group for Pancreatic Surgery project circulation list was created with pre-existing and new members and including gastroenterologists in addition to surgeons. A computerized search of the literature was undertaken for articles reporting the operative treatment of chronic pancreatitis. The results of the literature search were presented at the first face-to-face meeting of this International Study Group for Pancreatic Surgery project group. A document outlining proposed reporting standards was produced by discussion during an initial meeting of the International Study Group for Pancreatic Surgery. An electronic questionnaire was then sent to all current members of the International Study Group for Pancreatic Surgery. Responses were collated and further discussed at international meetings in North America, Europe, and at the International Association of Pancreatology World Congress in 2019. A final consensus document was produced by integration of multiple iterations. Results: The International Study Group for Pancreatic Surgery consensus standards for reporting of surgery in chronic pancreatitis recommends 4 core domains and the necessary variables needed for reporting of results: clinical baseline before operation; the morphology of the diseased gland; a new, standardized, operative terminology; and a minimum outcome dataset. The 4 domains combine to give a comprehensive framework for reports. Conclusion: Adoption of the 4 domains of the International Study Group for Pancreatic Surgery reporting standards for surgery for chronic pancreatitis will facilitate comparison of results between centers and help to improve the care for patients with this debilitating disease.
- Published
- 2020
24. Perioperative omega-3 fatty acids fail to confer protection in liver surgery: Results of a multicentric, double-blind, randomized controlled trial
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Michail Efanov, Rolf Graf, Christian E. Oberkofler, Christoph Tschuor, Ruslan Alikhanov, Patryk Kambakamba, Diana Nicolaescu, Philipp Kron, Michael Linecker, Igor Khatkov, Perparim Limani, Marcel André Schneider, Irinel Popescu, Henrik Petrowsky, Andrea Wirsching, Pierre-Alain Clavien, Michelle L. de Oliveira, Dimitri Aristotele Raptis, John M. Bonvini, P. Kim, Florin Botea, University of Zurich, and Clavien, Pierre-Alain
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Male ,0301 basic medicine ,Clavien ,FAs ,law.invention ,Comprehensive complication index ,Postoperative Complications ,0302 clinical medicine ,Randomized controlled trial ,law ,Prospective Studies ,Treatment Failure ,Infusions, Intravenous ,chemistry.chemical_classification ,Omega ,Mortality rate ,Liver Neoplasms ,Middle Aged ,Omegaven ,Major liver surgery ,Editorial ,Anesthesia ,Female ,030211 gastroenterology & hepatology ,Polyunsaturated fatty acid ,Adult ,610 Medicine & health ,Protective Agents ,Placebo ,Perioperative Care ,03 medical and health sciences ,Fish Oils ,Double-Blind Method ,Fatty Acids, Omega-3 ,medicine ,Humans ,3 polyunsaturated fatty acids ,Triglycerides ,Aged ,10217 Clinic for Visceral and Transplantation Surgery ,Dindo classification ,Hepatology ,CCI ,business.industry ,Perioperative ,medicine.disease ,030104 developmental biology ,chemistry ,Ω3 ,2721 Hepatology ,Steatosis ,Complication ,business - Abstract
Background & Aims In a variety of animal models, omega-3 polyunsaturated fatty acids (Ω3-FAs) conferred strong protective effects, alleviating hepatic ischemia/reperfusion injury and steatosis, as well as enhancing regeneration after major tissue loss. Given these benefits along with its safety profile, we hypothesized that perioperative administration of Ω3-FAs in patients undergoing liver surgery may ameliorate the postoperative course. The aim of this study was to investigate the perioperative use of Ω3-FAs to reduce postoperative complications after liver surgery. Methods Between July 2013 and July 2018, we carried out a multicentric, double-blind, randomized, placebo-controlled trial designed to test whether 2 single intravenous infusions of Omegaven® (Ω3-FAs) vs. placebo may decrease morbidity. The primary endpoints were postoperative complications by severity (Clavien-Dindo classification) integrated within the comprehensive complication index (CCI). Results A total of 261 patients (132 in the Omegaven and 129 in the placebo groups) from 3 centers were included in the trial. Most cases (87%, n = 227) underwent open liver surgery and 56% (n = 105) were major resections (≥3 segments). In an intention-to-treat analysis including the dropout cases, the mortality rate was 4% and 2% in the Omegaven and placebo groups (odds ratio0.40;95% CI 0.04–2.51; p = 0.447), respectively. Any complications and major complications (Clavien-Dindo ≥ 3b) occurred in 46% vs. 43% (p = 0.709) and 12% vs. 10% (p = 0.69) in the Omegaven and placebo groups, respectively. The mean CCI was 17 (±23) vs.14 (±20) (p = 0.417). An analysis excluding the dropouts provided similar results. Conclusions The routine perioperative use of 2 single doses of intravenous Ω3-FAs (100 ml Omegaven) cannot be recommended in patients undergoing liver surgery (Grade A recommendation). Lay summary Despite strong evidence of omega-3 fatty acids having liver-directed, anti-inflammatory and pro-regenerative action in various rodent models, 2 single omega-3 fatty acid infusions given to patients before and during liver surgery failed to reduce complications. Because single omega-3 fatty acid infusions failed to confer liver protection in this trial, they cannot currently be recommended. Trial registration: ClinicalTrial.gov: ID: NCT01884948; Institution Ethical Board Approval: KEK-ZH-Nr. 2010-0038; Swissmedic Notification: 2012DR3215.
- Published
- 2020
25. Prognostic relevance of preoperative bilirubin-adjusted serum carbohydrate antigen 19-9 in a multicenter subset analysis of 179 patients with distal cholangiocarcinoma
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Tobias Keck, Frank Makowiec, Ulrich F. Wellner, Ekaterina Petrova, Felix Rückert, Igor Khatkov, Bettina Rau, Uwe A. Wittel, Dirk Bausch, Jürgen Weitz, Louisa Bolm, Peter Bronsert, Hryhoriy Lapshyn, and Marius Distler
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Adult ,Male ,Subset Analysis ,medicine.medical_specialty ,CA-19-9 Antigen ,Bilirubin ,Malignancy ,Gastroenterology ,Cholangiocarcinoma ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Text mining ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,Lymph node ,Survival rate ,Aged ,Aged, 80 and over ,Hepatology ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Survival Rate ,medicine.anatomical_structure ,chemistry ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,business ,Carbohydrate antigen ,Biomarkers - Abstract
Background Distal cholangiocarcinoma (DCC) is a rare malignancy and validated prognostic markers remain scarce. We aimed to evaluate the role of serum CA19-9 as a potential biomarker in DCC. Methods Patients operated for DCC at 6 high-volume surgical centers from 1994 to 2015 were identified from prospectively maintained databases. Patient baseline characteristics, surgical and histopathological parameters, as well as overall survival after resection were assessed for correlation with preoperative bilirubin-adjusted serum carbohydrate antigen 19-9 (CA19-9). Preoperative CA19-9 to bilirubin ratio (CA19-9/BR) was classified as elevated (≥ 25 U/ml/mg/dl) according to the upper serum normal values of CA19-9 (37 U/ml) and bilirubin (1.5 mg/dl) giving a cut-off at ≥ 25 U/ml/mg/dl. Results In total 179 patients underwent resection for DCC during the study period. High preoperative CA19-9/BR was associated with advanced age and regional lymph node metastases. Median overall survival after resection was 27 months. Elevated preoperative serum CA19-9/bilirubin ratio (HR 1.6, p = 0.025), T3/4 stage (HR 1.8, p = 0.022), distant metastasis (HR 2.5, p = 0.007), tumor grade (HR 1.9, p = 0.001) and R status (HR 1.7, p = 0.023) were identified as independent negative prognostic factors following multivariable analysis. Conclusion Elevated preoperative bilirubin-adjusted serum CA19-9 correlates with regional lymph node metastases and constitutes a negative independent prognostic factor after resection of DCC.
- Published
- 2019
26. Laparoscopic versus open extended radical left pancreatectomy for pancreatic ductal adenocarcinoma: an international propensity-score matched study
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D. Gomez, Safi Dokmak, Frederik Berrevoet, Andrea Pietrabissa, Riccardo Casadei, Maarten Korrel, Adnan Alseidi, C. Krautz, Tobias Keck, O.R.C. Busch, A. Sa Cunha, Antonello Forgione, J. van Hilst, Bergthor Björnsson, Thilo Hackert, Ugo Boggi, A. Balduzzi, Brice Gayet, Jean-Michel Fabre, B. Groot Koerkamp, P.B. van den Boezem, Massimo Falconi, Ignasi Poves, Santiago Sánchez-Cabús, Giovanni Butturini, Ravi Marudanayagam, Zahir Soonawalla, Roberto Salvia, R. Van Dam, Mushegh A. Sahakyan, Bilal Al-Sarireh, Bjørn Edwin, S. Lof, Giorgio Ercolani, Marc G. Besselink, M. Abu Hilal, Igor Khatkov, K. Menon, Graduate School, CCA - Cancer Treatment and Quality of Life, Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, Balduzzi A., van Hilst J., Korrel M., Lof S., Al-Sarireh B., Alseidi A., Berrevoet F., Bjornsson B., van den Boezem P., Boggi U., Busch O.R., Butturini G., Casadei R., van Dam R., Dokmak S., Edwin B., Sahakyan M.A., Ercolani G., Fabre J.M., Falconi M., Forgione A., Gayet B., Gomez D., Koerkamp B.G., Hackert T., Keck T., Khatkov I., Krautz C., Marudanayagam R., Menon K., Pietrabissa A., Poves I., Cunha A.S., Salvia R., Sanchez-Cabus S., Soonawalla Z., Hilal M.A., Besselink M.G., RS: NUTRIM - R2 - Liver and digestive health, and MUMC+: MA Heelkunde (9)
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medicine.medical_specialty ,Left pancreatectomy ,ERLP ,030230 surgery ,SURGICAL COMPLICATIONS ,PANCREATOSPLENECTOMY ,CLASSIFICATION ,03 medical and health sciences ,0302 clinical medicine ,Pancreatectomy ,Retrospective Studie ,Internal medicine ,medicine ,Humans ,Lymph node ,Retrospective Studies ,Gastric emptying ,business.industry ,Cancer ,PDAC ,cohort ,Hepatology ,medicine.disease ,CANCER ,DISTAL PANCREATECTOMY ,Surgery ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Pancreatic Neoplasms ,DEFINITION ,medicine.anatomical_structure ,Treatment Outcome ,Propensity score matching ,Cohort ,030211 gastroenterology & hepatology ,Laparoscopy ,business ,Abdominal surgery ,Human ,Carcinoma, Pancreatic Ductal ,Extended resection - Abstract
Item does not contain fulltext BACKGROUND: A radical left pancreatectomy in patients with pancreatic ductal adenocarcinoma (PDAC) may require extended, multivisceral resections. The role of a laparoscopic approach in extended radical left pancreatectomy (ERLP) is unclear since comparative studies are lacking. The aim of this study was to compare outcomes after laparoscopic vs open ERLP in patients with PDAC. METHODS: An international multicenter propensity-score matched study including patients who underwent either laparoscopic or open ERLP (L-ERLP; O-ERLP) for PDAC was performed (2007-2015). The ISGPS definition for extended resection was used. Primary outcomes were overall survival, margin negative rate (R0), and lymph node retrieval. RESULTS: Between 2007 and 2015, 320 patients underwent ERLP in 34 centers from 12 countries (65 L-ERLP vs. 255 O-ERLP). After propensity-score matching, 44 L-ERLP could be matched to 44 O-ERLP. In the matched cohort, the conversion rate in L-ERLP group was 35%. The L-ERLP R0 resection rate (matched cohort) was comparable to O-ERLP (67% vs 48%; P = 0.063) but the lymph node yield was lower for L-ERLP than O-ERLP (median 11 vs 19, P = 0.023). L-ERLP was associated with less delayed gastric emptying (0% vs 16%, P = 0.006) and shorter hospital stay (median 9 vs 13 days, P = 0.005), as compared to O-ERLP. Outcomes were comparable for additional organ resections, vascular resections (besides splenic vessels), Clavien-Dindo grade ≥ III complications, or 90-day mortality (2% vs 2%, P = 0.973). The median overall survival was comparable between both groups (19 vs 20 months, P = 0.571). Conversion did not worsen outcomes in L-ERLP. CONCLUSION: The laparoscopic approach may be used safely in selected patients requiring ERLP for PDAC, since morbidity, mortality, and overall survival seem comparable, as compared to O-ERLP. L-ERLP is associated with a high conversion rate and reduced lymph node yield but also with less delayed gastric emptying and a shorter hospital stay, as compared to O-ERLP.
- Published
- 2021
27. Mentorship in Training of Minimally Invasive Pancreatoduodenectomy
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Abe Fingerhut, Pavel Tyutyunnik, Roman Izrailov, Mikhail Efanov, Magomet Baychorov, and Igor Khatkov
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Surgery - Published
- 2022
28. Percutaneous radiofrequency‐assisted liver partition versus portal vein embolization before hepatectomy for perihilar cholangiocarcinoma
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Mikhail Efanov, O. V. Melekhina, I. Kazakov, Y. Kulezneva, Victor Tsvirkun, A. Vankovich, A. Koroleva, Ruslan Alikhanov, and Igor Khatkov
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Adult ,Male ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,lcsh:Surgery ,030230 surgery ,Muscle hypertrophy ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Hepatectomy ,Humans ,Stage (cooking) ,Perihilar Cholangiocarcinoma ,Aged ,business.industry ,Surrogate endpoint ,Portal Vein ,Liver failure ,General Medicine ,lcsh:RD1-811 ,Original Articles ,Middle Aged ,Embolization, Therapeutic ,Surgery ,Survival Rate ,Treatment Outcome ,Bile Duct Neoplasms ,Liver ,030220 oncology & carcinogenesis ,HPB ,Case-Control Studies ,Portal vein embolization ,Original Article ,Female ,business ,Klatskin Tumor - Abstract
Background Percutaneous radiofrequency‐assisted liver partition with portal vein embolization in staged liver resection (PRALPPS) represents an alternative to portal vein embolization (PVE) followed by major liver resection in patients with perihilar cholangiocarcinoma. Methods This was an observational case–control study. Both procedures were applied in patients with a future liver remnant (FLR) volume of less than 40 per cent. The main end points of the study were short‐term morbidity and mortality for the two procedures. The study also compared the efficacy of the preresection phases estimated by kinetic growth rate (KGR), time interval and degree of hypertrophy of the FLR. Results The first phase (preresection) was completed in 11 and 18 patients, and the second phase (resection) in nine and 14 patients, in the PRALPPS and PVE groups respectively. Major morbidity after the first stage did not differ between the groups. There were no differences in blood loss, severe morbidity or liver failure rate after the second stage, with no deaths. The mean KGR of the FLR after the preresection phase for PRALPPS was 3·8 (0·6–9·8) per cent/day, and that after PVE was 1·8 (0–6·7) per cent/day (P = 0·037). The mean time interval for FLR hypertrophy in the PRALPPS and PVE groups was 15 (6–29) and 20 (8–35) days respectively (P = 0·039). Conclusion Short‐term outcomes were similar for PRALPPS and PVE in terms of safety. Remnant hypertrophy was achieved more rapidly by PRALPPS., Percutaneous radiofrequency‐assisted liver partition with portal vein embolization in staged liver resection (PRALPPS), modIfied ALPPS with reduced surgical trauma on the first stage, was used in 11 patients with perihilar cholangiocarcinoma. PRALPPS did not differ from portal vein embolization (PVE) in terms of morbidity or mortality. The kinetic growth rate and mean time interval for future liver remnant hypertrophy in the PRALPPS group were significantly better than those in the PVE group. Similar complication rates and outcomes
- Published
- 2019
29. Prediction of postpancreatoduodenectomy pancreatic fistula with the use of computer tomography
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S. A. Domrachev, N. S. Starostina, Victor Tsvirkun, P. Tyutyunnik, Yu. V. Kulezneva, А. V. Andrianov, K. A. Les’ko, B. S. Nikitin, Roman Izrailov, V. V. Schadrova, M. Baychorov, O. S. Vasnev, M. Mikhnevich, and Igor Khatkov
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medicine.medical_specialty ,Radiological and Ultrasound Technology ,business.industry ,Fistula ,Early detection ,medicine.disease ,Asymptomatic ,Pancreatic surgery ,medicine.anatomical_structure ,Pancreatic fistula ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,medicine.symptom ,Surgical treatment ,Pancreas ,business ,Grading (tumors) - Abstract
Aim. To reveal and evaluate opportunities of preoperative computer tomography (CT) for pancreatic fistula (PF) prediction after pancreatoduodenectomy. Materials and methods . In 2005 International Study Group on Pancreatic Fistula (ISGPF) developed grading criteria for PF, including asymptomatic biochemical (Grade A), that could be treated conservatively, and clinically relevant (Grade B, Grade C), with consecutive active surgical treatment. For now ISGPF definition of PF is widely accepted. We review the literature since 2005 for original articles in English describing quantitive assessment of the pancreatic parenchyma using CT with histological validation. Low sample trials (
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- 2019
30. Risk of conversion to open surgery during robotic and laparoscopic pancreatoduodenectomy and effect on outcomes: international propensity score-matched comparison study
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A. Coratti, R. Fara, Mathieu D'Hondt, Sebastiaan Festen, F. Vissers, Ugo Boggi, Alberto Manzoni, M. Luyer, M.G. Besselink, S. Berti, O. Saint-Marc, Sjors Klompmaker, Safi Dokmak, Daan J. Lips, S. Lof, Edoardo Rosso, M. Abu Hilal, Igor Khatkov, Graduate School, Surgery, CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
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Age Factors ,Aged ,Conversion to Open Surgery ,Female ,Humans ,Laparoscopy ,Logistic Models ,Male ,Middle Aged ,Pancreatic Neoplasms ,Pancreaticoduodenectomy ,Propensity Score ,Retrospective Studies ,Risk Factors ,Treatment Outcome ,medicine.medical_specialty ,medicine.medical_treatment ,Logistic regression ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Post-hoc analysis ,medicine ,business.industry ,Mortality rate ,Retrospective cohort study ,Odds ratio ,Confidence interval ,030220 oncology & carcinogenesis ,Propensity score matching ,030211 gastroenterology & hepatology ,Surgery ,business - Abstract
Background Minimally invasive pancreatoduodenectomy (MIPD) is increasingly being performed because of perceived patient benefits. Whether conversion of MIPD to open pancreatoduodenectomy worsens outcome, and which risk factors are associated with conversion, is unclear. Methods This was a post hoc analysis of a European multicentre retrospective cohort study of patients undergoing MIPD (2012–2017) in ten medium-volume (10–19 MIPDs annually) and four high-volume (at least 20 MIPDs annually) centres. Propensity score matching (1 : 1) was used to compare outcomes of converted and non-converted MIPD procedures. Multivariable logistic regression analysis was performed to identify risk factors for conversion, with results presented as odds ratios (ORs) with 95 per cent confidence intervals (c.i). Results Overall, 65 of 709 MIPDs were converted (9.2 per cent) and the overall 30-day mortality rate was 3.8 per cent. Risk factors for conversion were tumour size larger than 40 mm (OR 2.7, 95 per cent c.i.1.0 to 6.8; P = 0.041), pancreatobiliary tumours (OR 2.2, 1.0 to 4.8; P = 0.039), age at least 75 years (OR 2.0, 1.0 to 4.1; P = 0.043), and laparoscopic pancreatoduodenectomy (OR 5.2, 2.5 to 10.7; P Conclusion Risk factors for conversion during MIPD include age, large tumour size, tumour location, laparoscopic approach, and surgery in medium-volume centres. Although conversion during MIPD itself was not associated with worse outcomes, the outcome in these patients was poor in general which should be taken into account during patient selection for MIPD.
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- 2021
31. Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
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Melania Macarie, Dániel Pécsi, Bálint Erőss, Emese Tóth, Alexandra Mikó, Viktória Venglovecz, Péter Mátrai, Zoltán Szepes, Alexandra Soós, Áron Vincze, Ferenc Izbéki, Attila Ébert, József Hamvas, György Kovács, Tanya Bideeva, Ville Sallinen, Balázs Németh, Péter Jenő Hegyi, Péter Hegyi, Márta Varga, László Czakó, Dmitry S. Bordin, Ali Tüzün Ince, Andrea Szentesi, Elena Ramirez-Maldonado, E.A. Dubtsova, Mária Papp, Adrienn Halász, Mariya A. Kiryukova, Judit Bajor, Patrícia Sarlós, Zsolt Dubravcsik, Artautas Mickevicius, Katalin Márta, Igor Khatkov, Andrea Párniczky, László Tiszlavicz, Clinicum, HUS Abdominal Center, Pertti Panula / Principal Investigator, Department of Anatomy, II kirurgian klinikka, University of Helsinki, Helsinki University Hospital Area, IV kirurgian klinikka, and İNCE, ALİ TÜZÜN
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Male ,medicine.medical_specialty ,Cross-sectional study ,Science ,Population ,Disease ,Gastroenterology ,Article ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Internal medicine ,Pancreatitis, Chronic ,medicine ,Animals ,Humans ,Registries ,Risk factor ,education ,Pancreatic disease ,Gastrointestinal diseases ,education.field_of_study ,Multidisciplinary ,business.industry ,Middle Aged ,medicine.disease ,a cross-sectional multicentre international study with experimental animal model.-, Scientific reports, cilt.11, ss.1367, 2021 [Hegyi P. J. , Soós A., Tóth E., Ébert A., Venglovecz V., Márta K., Mátrai P., Mikó A., Bajor J., Sarlós P., et al., -Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis] ,3. Good health ,Clinical trial ,Disease Models, Animal ,medicine.anatomical_structure ,Cross-Sectional Studies ,Early Diagnosis ,Pancreatitis ,030220 oncology & carcinogenesis ,3121 General medicine, internal medicine and other clinical medicine ,Acute pancreatitis ,Medicine ,030211 gastroenterology & hepatology ,Female ,Pancreas ,business - Abstract
Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.
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- 2021
32. First Year of the European Registry for Minimally Invasive Pancreatic Surgery (E-MIPS)
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Alberto Manzoni, M. D'Hondt, A. Kokkola, S. Gaujoux, Mario Serradilla-Martín, H.C. van Santvoort, M. Luyer, N. van der Heijde, Giuseppe Zimmitti, M. Maglione, Svein Olav Bratlie, S. Sanchez Cabús, B. Groot Koerkamp, G. van der Schelling, D.J. Lips, Patrick Pessaux, Frederik Berrevoet, Francois Regis Souche, A. Coratti, Geert Roeyen, Safi Dokmak, Fernando Burdío, Antonello Forgione, R. Fara, M.G. Besselink, T. Hackert, F. Vissers, Bergthor Björnsson, P.B. van den Boezem, J. Balsells, M. Vito Marino, C. Fristrup, D. Del Pozo, Sebastiaan Festen, Ugo Boggi, M.A. Suarez Muñoz, M. Fatih Can, M. Abu Hilal, Igor Khatkov, Tobias Keck, I.Q. Molenaar, Gabriella Pittau, and O. Saint-Marc
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medicine.medical_specialty ,Hepatology ,business.industry ,General surgery ,Gastroenterology ,medicine ,business ,Pancreatic surgery - Published
- 2021
33. Predictors for Survival in an International Cohort of Patients Undergoing Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma
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Bjørn Edwin, S. van Dieren, Thilo Hackert, J. van Hilst, Tobias Keck, O.R.C. Busch, Adnan Alseidi, Giuseppe Malleo, Marc G. Besselink, Claudio Bassi, Maarten Korrel, M. Abu Hilal, Ignasi Poves, Igor Khatkov, David Fuks, S. Lof, Mushegh A. Sahakyan, Ugo Boggi, Graduate School, Surgery, CCA - Cancer Treatment and Quality of Life, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Public Health, and APH - Methodology
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medicine.medical_specialty ,Pàncrees -- Tumors ,medicine.medical_treatment ,Pancreatic Ductal Adenocarcinoma ,survival, distal pancreatectomy, Pancreatic Ductal Adenocarcinoma ,Adenocarcinoma ,survival ,Pancreatectomy ,Pàncrees -- Cirurgia ,Surgical oncology ,Interquartile range ,medicine ,Humans ,distal pancreatectomy ,Lymph node ,Retrospective Studies ,business.industry ,Hazard ratio ,Retrospective cohort study ,Pancreatic Tumors ,Fascia ,Surgery ,Europe ,Pancreatic Neoplasms ,Survival Rate ,medicine.anatomical_structure ,Oncology ,Cohort ,Lymphadenectomy ,Female ,business ,Carcinoma, Pancreatic Ductal - Abstract
Background Surgical factors, including resection of Gerota’s fascia, R0-resection, and lymph node yield, may be associated with survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC), but evidence from large multicenter studies is lacking. This study aimed to identify predictors for overall survival after DP for PDAC, especially those related to surgical technique. Patients and Methods Data from an international retrospective cohort including patients from 11 European countries and the USA who underwent DP for PDAC (2007–2015) were analyzed. Cox proportional hazard analyses were performed and included Gerota’s fascia resection, R0 resection, lymph node ratio, extended resection, and a minimally invasive approach. Results Overall, 1200 patients from 34 centers with median follow-up of 15 months [interquartile range (IQR) 5–31 months] and median survival period of 30 months [95% confidence interval (CI), 27–33 months] were included. Gerota’s fascia resection [hazard ratio (HR) 0.74; p = 0.019], R0 resection (HR 0.70; p = 0.006), and decreased lymph node ratio (HR 0.28; p p p = 0.350). Adjuvant chemotherapy (HR 0.67; p = 0.003) was also associated with improved overall survival. Conclusions This international cohort identified Gerota’s fascia resection, R0 resection, and decreased lymph node ratio as factors associated with improved overall survival during DP for PDAC. Surgeons should strive for R0 resection and adequate lymphadenectomy and could also consider Gerota’s fascia resection in their routine surgical approach.
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- 2021
34. A randomized prospective study of the immediate outcomes of the use of a hydro-jet dissector and an ultrasonic surgical aspirator for laparoscopic liver resection
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Ruslan Alikhanov, A. Koroleva, Victor Tsvirkun, D. Salimgereeva, Dmitry Kovalenko, Mikhail Efanov, A. Vankovich, Igor Khatkov, and I. Kazakov
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medicine.medical_specialty ,Blood Loss, Surgical ,Aspirator ,Single Center ,law.invention ,Resection ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Parenchyma ,medicine ,Clinical endpoint ,Hepatectomy ,Humans ,Ultrasonics ,Prospective Studies ,Prospective cohort study ,Hepatology ,business.industry ,Dissection ,Liver Neoplasms ,Gastroenterology ,Surgery ,Liver ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Laparoscopy ,business - Abstract
Background No prospective randomized trials comparing transection techniques for the liver parenchyma transection during laparoscopic liver resection have been performed. The aim of the study was to compare the immediate outcomes of hydro-jet dissection with ultrasonic surgical aspirator in laparoscopic liver parenchyma transection in a prospective randomized single-center study. Methods Consecutive patients with liver benign and malignant tumors presenting to a single center from May 2017 to May 2020 were enrolled in the study. The primary endpoint was the intraoperative estimated blood loss. The secondary endpoints included duration of parenchymal transection, morbidity, and overall hospital stay. Results A total of 68 patients were enrolled in the study, with 34 patients in each group. There were no differences between groups in the difficulty of resection (according to IWATE criteria and IMM score) and other basic surgical parameters. No differences were found in all primary and secondary endpoints except the expenditure. The cost of equipment was significantly higher in the group of ultrasonic aspirator. Conclusion Despite the wider use of the ultrasonic aspirator in laparoscopic liver surgery, hydro-jet and ultrasonic surgical aspirators have shown similar efficacy and safety for transection of the liver parenchyma during laparoscopic resection.
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- 2020
35. Robotic and open resection of the liver and bile ducts for perihilar cholangiocarcinoma. Comparative analysis of the short-term outcomes
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Natalia Elizarova, Mikhail Efanov, Ruslan Alikhanov, Ivan Kazakov, Olga Melekhina, Yuliya Kulezneva, Anna Koroleva, Andrey Vankovich, and Igor Khatkov
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Surgery ,General Medicine - Published
- 2022
36. Pancreatic Hydatid Cyst Misdiagnosed as Mucinous Cystadenoma: CT and MRI Findings
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Jelena Djokić Kovač, Nikola Grubor, Slavko Matic, Igor Khatkov, Aleksandra Jankovic, Vladimir Milosavljevic, Boris Tadic, Milica Mitrovic, and Dejan Radenkovic
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medicine.medical_specialty ,Medicine (General) ,laparoscopy ,Case Report ,Hydatid cyst ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Echinococcosis ,Cystadenoma, Mucinous ,parasitic diseases ,medicine ,Animals ,Humans ,Cyst ,distal pancreatectomy ,pancreas ,Diagnostic Errors ,Laparoscopy ,Echinococcus granulosus ,Mucinous cystadenoma ,hydatid cyst ,Aged ,medicine.diagnostic_test ,biology ,business.industry ,pancreatic cyst ,imaging ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,biology.organism_classification ,echinococcus granulosus ,3. Good health ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cattle ,Female ,030211 gastroenterology & hepatology ,Radiology ,Tomography, X-Ray Computed ,Distal pancreatectomy ,Pancreas ,business - Abstract
Isolated hydatid cysts of the pancreas are rare lesions, even in endemic regions. In this report, we present the case of a 76-year-old patient who was admitted to our clinic with a diagnosis of a cystic lesion in the tail of the pancreas. On preoperative computed tomography (CT) and magnetic resonance (MR) examination, the cyst was characterized as a mucinous cystadenoma. A laparoscopic distal pancreatectomy followed. A histopathological examination revealed a large hydatid cyst in the tail of the pancreas.
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- 2020
37. Robotic rectal resection: preliminary Russian experience
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Yuri Streltsov, Igor Dolgopyatov, Georgi Saakjan, Andrey Atroshchenko, Vladimir Yegorov, Mikhail Danilov, Sergey Chudnikh, Stepan Pozdnyakov, Igor Khatkov, and Zaira Abdulatipova
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medicine.medical_specialty ,Colorectal cancer ,business.industry ,Gastroenterology ,Robotic surgery ,RC799-869 ,Diseases of the digestive system. Gastroenterology ,medicine.disease ,Total mesorectal excision ,Colorectal surgery ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cohort ,medicine ,030211 gastroenterology & hepatology ,Brief Pain Inventory ,Rectal cancer ,business ,Lymph node ,Mesorectal - Abstract
Purpose: To outline the preliminary experience of the da Vinci® robotic system used in a Moscow tertiary colorectal referral center for an unselected range of benign and malignant rectal conditions. Methods: Prospective non-randomized single-center study which analyzed results of 26 robotic rectal resections performed between january 2014 and december 2016. Results: The cohort included 10 females and 16 males (mean total age 61.6 years). Three patients underwent surgery for benign rectal villous adenomas. The median overall ASA score was 4 (ranged from 2 to 5). Of the surgeries, there were 19 total mesorectal excisions with 6 patients undergoing a multivisceral resection. The mean operating time was 358 minutes with a mean blood loss of 203 mL. All total mesorectal excision specimens were adjudged according Philip Quirke classification as mesorectal plane – Grade 3 with a mean of 18.5 lymph nodes identified (from 12 to 35). Of these there were 10 patients (38.5%) with lymph node metastases. After surgery the average pain score was 2.1 out of 10 on the “Visual-Analogue Pain Intensity Scale” and 1.5 score out of 10 on the “Brief Pain Inventory with Quality of Life”. Anal continency after rectal resection with total mesorectal excisions estimated according Wexner Scale: 10 days after surgery average score was −3.1 and a 6 month after surgery −1.6 score. The median length of hospital stay was 11 days (from 10 to 15). Conclusion: Our initial experience with a totally robotic rectal resection has shown the technique to be safe and feasible, particularly in patients where conventional laparoscopic rectal resection would be anticipated to be challenging. Resumo: Objetivo: Delinear a experiência preliminar do sistema robótico da Vinci® usado em um centro de referência colorretal terciário de Moscou para uma gama não selecionada de problemas retais benignos e malignos. Métodos: Estudo unicêntrico prospectivo não randomizado que analisou os resultados de 26 ressecções retais robóticas realizadas entre janeiro de 2014 e dezembro de 2016. Resultados: A coorte incluiu 10 mulheres e 16 homens (idade total média de 61,6 anos). Três pacientes foram submetidos à cirurgia para adenomas vilosos retais benignos. O escore global mediano da ASA foi de 4 (variou de 2 a 5). Das cirurgias, houve 19 excisões mesorretais totais com 6 pacientes submetidos à ressecção multivisceral. O tempo médio de cirurgia foi de 358 minutos, com perda sanguínea média de 203 mL. Todas as amostras de excisão total do mesorreto foram classificadas de acordo com a classificação de Philip Quirke como plano mesorretal - Grau 3 com uma média de 18,5 linfonodos identificados (de 12 a 35). Destes, havia 10 pacientes (38,5%) com metástases linfonodais. Após a cirurgia, o escore médio de dor foi de 2,1 de 10 na Escala de Intensidade da Dor Visual-Analógica e de 1,5 de 10 no “Inventário Breve de Dor com Qualidade de Vida”. Continência anal após ressecção retal com excisões totais mesorretais estimadas de acordo com a Escala de Wexner: 10 dias após a cirurgia o escore médio foi -3,1 e um escore de -1,6 após 6 meses da cirurgia. A mediana do tempo de internação foi de 11 dias (de 10 a 15). Conclusão: Nossa experiência inicial com uma ressecção retal totalmente robótica mostrou que a técnica é segura e viável, particularmente em pacientes nos quais a ressecção retal laparoscópica convencional seria prevista como um desafio. Keywords: Robotic surgery, Rectal cancer, Colorectal surgery, Palavras-chave: Cirurgia robótica, Câncer retal, Cirurgia colorretal
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- 2018
38. The European Registry for Minimally Invasive Pancreatic Surgery (E-MIPS): First Year Experience
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F. Vissers, M.G. Besselink, O. Saint-Marc, T. Hackert, M. Abu Hilal, Igor Khatkov, N. van der Heijde, Giuseppe Zimmitti, and F. Can
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medicine.medical_specialty ,Hepatology ,business.industry ,General surgery ,Gastroenterology ,medicine ,business ,Pancreatic surgery - Published
- 2021
39. Long term oncological outcomes of laparoscopic pancreatoduodenectomy
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J. Normedova, R. Izrailov, M. Baychorov, and Igor Khatkov
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medicine.medical_specialty ,Hepatology ,business.industry ,General surgery ,Gastroenterology ,medicine ,business ,Term (time) - Published
- 2021
40. External validation of four different models of prediction the clinically relevant pancreatic fistula after laparoscopic pancreatoduodenectomy
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R. Izrailov, P. Agami, P. Tytyunnik, M. Baychorov, A. Andrianov, Igor Khatkov, O. Vasnev, and M. Mikhnevich
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medicine.medical_specialty ,Hepatology ,business.industry ,Pancreatic fistula ,Gastroenterology ,External validation ,Medicine ,Radiology ,business ,medicine.disease - Published
- 2021
41. Risk Factors of Serious Postoperative Complications after Laparoscopic Pancreatoduodenectomy: Single Center Retrospective Study
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O. Vasnev, A. Andrianov, M. Mikhnevich, M. Baychorov, P. Tytyunnik, P. Agami, Igor Khatkov, and R. Izrailov
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medicine.medical_specialty ,Hepatology ,business.industry ,General surgery ,Gastroenterology ,Medicine ,Retrospective cohort study ,business ,Single Center - Published
- 2021
42. 358 total laparoscopic pancreatoduodenectomy for patients with lesions of the head of the pancreas and periampullary area
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P. Tyutyunnik, P. Agami, O. Vasnev, M. Mikhnevich, A. Andrianov, D. Salimgereeva, R. Izrailov, Victor Tsvirkun, Igor Khatkov, and M. Baychorov
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medicine.medical_specialty ,medicine.anatomical_structure ,Hepatology ,business.industry ,Gastroenterology ,Medicine ,Head (vessel) ,Radiology ,business ,Pancreas - Published
- 2021
43. The European registry for Minimally Invasive Pancreatic Surgery (E-MIPS): First year experience
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N. van der Heijde, F. Vissers, O. Saint-Marc, F. Can, M.G. Besselink, T. Hackert, M. Abu Hilal, and Igor Khatkov
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medicine.medical_specialty ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,General surgery ,Gastroenterology ,Medicine ,business ,Pancreatic surgery - Published
- 2020
44. The Russian consensus on the diagnosis and treatment of chronic pancreatitis: Enzyme replacement therapy
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Dmitry S. Bordin, E A Kornienko, E. V. Bystrovskaya, N Yu Kokhanenko, N.I. Ursova, T G Dyuzheva, Igor Khatkov, V. D. Pasechnikov, Igor G. Bakulin, Maria A. Livzan, Emilia Galperin, N. V. Korochanskaya, E V Beloborodova, E.I. Alieva, A. V. Okhlobystin, S I Polyakova, V L Korobka, Sayar Abdulkhakov, S V Vertyankin, Oleg A. Sablin, M F Osipenko, I D Loranskaya, Yu A Kucheryavyi, E. A. Belousova, A Yu Baranovsky, V V Tsukanov, V E Zagainov, Mikhail Efanov, Roman Izrailov, A.V. Gorelov, E Yu Plotnikova, V I Egorov, E.A. Dubtsova, V I Simanenkov, Zakharova Nv, R B Alikhanov, K.A. Nikolskaya, Victor Tsvirkun, Vladimir Ivashkin, A V Shabunin, Grinevich Vb, S A Alekseenko, V V Darvin, M V Danilov, L V Vinokurova, I M Buriev, and Igor V. Maev
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History ,Pathology ,medicine.medical_specialty ,Consensus ,diagnosis ,Endocrinology, Diabetes and Metabolism ,lcsh:Medicine ,Moscow ,chronic pancreatitis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Pancreatitis, Chronic ,Diagnosis ,medicine ,Humans ,treatment ,business.industry ,lcsh:R ,virus diseases ,Disease Management ,General Medicine ,Enzyme replacement therapy ,medicine.disease ,Treatment ,030220 oncology & carcinogenesis ,Pancreatitis ,030211 gastroenterology & hepatology ,russian consensus ,Family Practice ,business ,Chronic pancreatitis ,geographic locations ,enzyme replacement therapy - Abstract
Pancreatology Club Professional Medical Community, 1A.S. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow; 2A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow; 3Kazan State Medical University, Ministry of Health of Russia, Kazan; 4Kazan (Volga) Federal University, Kazan; 5Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk; 6Morozov City Children's Clinical Hospital, Moscow Healthcare Department, Moscow; 7I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg; 8Siberian State Medical University, Ministry of Health of Russia, Tomsk; 9M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow; 10Maimonides State Classical Academy, Moscow; 11V.I. Razumovsky State Medical University, Ministry of Health of Russia, Saratov; 12I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow; 13S.M. Kirov Military Medical Academy, Ministry of Defense of Russia, Saint Petersburg; 14Surgut State Medical University, Ministry of Health of Russia, Surgut; 15City Clinical Hospital Five, Moscow Healthcare Department, Moscow; 16Nizhny Novgorod Medical Academy, Ministry of Health of Russia, Nizhny Novgorod; 17Territorial Clinical Hospital Two, Ministry of Health of the Krasnodar Territory, Krasnodar; 18Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg; 19Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don; 20Omsk Medical University, Ministry of Health of Russia, Omsk; 21Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow; 22Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk; 23Stavropol State Medical University, Ministry of Health of Russia, Stavropol; 24Kemerovo State Medical University, Ministry of Health of Russia, Kemerovo; 25N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 26A.M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Russian Ministry for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters, Saint Petersburg; 27Research Institute for Medical Problems of the North, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk; 28S.P. Botkin City Clinical Hospital, Moscow Healthcare Department, Moscow; 29Tver State Medical University, Ministry of Health of Russia, Tver The Russian consensus on the diagnosis and treatment of chronic pancreatitis has been prepared on the initiative of the Russian Pancreatology Club to clarify and consolidate the opinions of Russian specialists (gastroenterologists, surgeons, and pediatricians) on the most significant problems of diagnosis and treatment of chronic pancreatitis. This article continues a series of publications explaining the most significant interdisciplinary consensus statements and deals with enzyme replacement therapy.Российский консенсус по диагностике и лечению хронического панкреатита подготовлен по инициативе Российского 'Панкреатологического клуба' с целью выяснения и консолидации мнений отечественных специалистов (гастроэнтерологов, хирургов и педиатров) по наиболее важным проблемам диагностики и лечения хронического панкреатита. Настоящая статья продолжает серию публикаций, разъясняющих наиболее важные положения междисциплинарного консенсуса и посвящена вопросам заместительной ферментной терапии.
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- 2017
45. Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study
- Author
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Giovanni Butturini, Santiago Sánchez-Cabús, Igor Khatkov, Sophia Chikhladze, Susan van Dieren, John N. Primrose, Isacco Damoli, Olivier R. Busch, Marco Montorsi, Ugo Boggi, Irfan Kabir, Marco Del Chiaro, Per Sandström, Bas Groot Koerkamp, Guido A. M. Tiberio, Zahir Soonawalla, K. Menon, Andrea Pietrabissa, Robert P. Sutcliffe, Lauren Scovel, Steven A. White, Brice Gayet, Riccardo Casadei, Bergthor Björnsson, Safi Dokmak, Alessandro Zerbi, Zeeshan Ateeb, Leonardo Solaini, Ignaci Poves, Federica Cipriani, Roberto Troisi, Jean-Marie Fabre, Ales Tomazic, Massimo Falconi, Tobias Keck, Marc G. Besselink, Claudio Ricci, Claudio Bassi, Ryne Marshall, Bilal Al-Sarireh, Uwe A. Wittel, Sjors Klompmaker, Frederik Berrevoet, Marion Orville, Casper H.J. van Eijck, Matthias Hassenpflug, Antonello Forgione, Mushegh A. Sahakyan, Bjørn Edwin, Masa Kusar, Gianpaolo Balzano, F. Régis Souche, Francesca Aleotti, Bård I. Røsok, M. Rawashdeh, Francesca Gavazzi, Giovanni Marchegiani, Adnan Alseidi, Carlo Lombardo, Thijs de Rooij, David Fuks, Ulrich F. Wellner, Thilo Hackert, Olivier Farges, Mohammad Abu Hilal, Jony van Hilst, Laureano Fernández-Cruz, Ronald M. van Dam, Isabella Frigerio, Raffaele Pugliese, Keith J. Roberts, Matteo De Pastena, Alessandro Giardino, Service de chirurgie hepato-pancreato-biliaire, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), San Raffaele Scientific Institute, Vita-Salute San Raffaele University and Center for Translational Genomics and Bioinformatics, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Van Hilst, Jony, De Rooij, Thij, Klompmaker, Sjor, Rawashdeh, Majd, Aleotti, Francesca, Al sarireh, Bilal, Alseidi, Adnan, Ateeb, Zeeshan, Balzano, Gianpaolo, Berrevoet, Frederik, Björnsson, Bergthor, Boggi, Ugo, Busch, Olivier R, Butturini, Giovanni, Casadei, Riccardo, Del Chiaro, Marco, Chikhladze, Sophia, Cipriani, Federica, Van Dam, Ronald, Damoli, Isacco, Van Dieren, Susan, Dokmak, Safi, Edwin, Bjørn, Van Eijck, Casper, Fabre, Jean marie, Falconi, Massimo, Farges, Olivier, Fernández cruz, Laureano, Forgione, Antonello, Frigerio, Isabella, Fuks, David, Gavazzi, Francesca, Gayet, Brice, Giardino, Alessandro, Bas Groot, Koerkamp, Hackert, Thilo, Hassenpflug, Matthia, Kabir, Irfan, Keck, Tobia, Khatkov, Igor, Kusar, Masa, Lombardo, Carlo, Marchegiani, Giovanni, Marshall, Ryne, Menon, Krish V, Montorsi, Marco, Orville, Marion, De Pastena, Matteo, Pietrabissa, Andrea, Poves, Ignaci, Primrose, John, Pugliese, Raffaele, Ricci, Claudio, Roberts, Keith, Røsok, Bård, Sahakyan, Mushegh A, Sánchez cabús, Santiago, Sandström, Per, Scovel, Lauren, Solaini, Leonardo, Soonawalla, Zahir, Souche, F. Régi, Sutcliffe, Robert P, Tiberio, Guido A, Tomazic, Aleš, Troisi, Roberto, Wellner, Ulrich, White, Steven, Wittel, Uwe A, Zerbi, Alessandro, Bassi, Claudio, Besselink, Marc G, Abu Hilal, Mohammed, Van Hilst, J., De Rooij, T., Klompmaker, S., Rawashdeh, M., Aleotti, F., Al-Sarireh, B., Alseidi, A., Ateeb, Z., Balzano, G., Berrevoet, F., Bjornsson, B., Boggi, U., Busch, O. R., Butturini, G., Casadei, R., Del Chiaro, M., Chikhladze, S., Cipriani, F., Van Dam, R., Damoli, I., Van Dieren, S., Dokmak, S., Edwin, B., Van Eijck, C., Fabre, J. -M., Falconi, M., Farges, O., Fernandez-Cruz, L., Forgione, A., Frigerio, I., Fuks, D., Gavazzi, F., Gayet, B., Giardino, A., Groot Koerkamp, B., Hackert, T., Hassenpflug, M., Kabir, I., Keck, T., Khatkov, I., Kusar, M., Lombardo, C., Marchegiani, G., Marshall, R., Menon, K. V., Montorsi, M., Orville, M., De Pastena, M., Pietrabissa, A., Poves, I., Primrose, J., Pugliese, R., Ricci, C., Roberts, K., Rosok, B., Sahakyan, M. A., Sanchez-Cabus, S., Sandstrom, P., Scovel, L., Solaini, L., Soonawalla, Z., Souche, F. R., Sutcliffe, R. P., Tiberio, G. A., Tomazic, A., Troisi, R., Wellner, U., White, S., Wittel, U. A., Zerbi, A., Bassi, C., Besselink, M. G., Abu Hilal, M., Graduate School, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, Surgery, APH - Methodology, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon, and CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Male ,[SDV]Life Sciences [q-bio] ,030230 surgery ,robot-assisted ,laparoscopic ,distal pancreatectomy, laparoscopic, left pancreatectomy, minimally invasive, robot-assisted ,0302 clinical medicine ,Postoperative Complications ,Pan european ,Robotic Surgical Procedures ,Medicine ,distal pancreatectomy ,Incidence ,3. Good health ,Europe ,Survival Rate ,medicine.anatomical_structure ,left pancreatectomy ,Treatment Outcome ,030220 oncology & carcinogenesis ,Female ,Distal pancreatectomy ,Pancreas ,Cohort study ,Carcinoma, Pancreatic Ductal ,medicine.medical_specialty ,Adenocarcinoma ,Article ,03 medical and health sciences ,Pancreatectomy ,Carcinoma ,Humans ,Minimally Invasive Surgical Procedures ,Ductal adenocarcinoma ,Propensity Score ,Aged ,Neoplasm Staging ,Retrospective Studies ,business.industry ,Retrospective cohort study ,Length of Stay ,medicine.disease ,digestive system diseases ,Surgery ,Pancreatic Neoplasms ,Propensity score matching ,minimally invasive ,Pàncrees -- Càncer -- Tractament ,Laparoscopy ,business - Abstract
International audience; OBJECTIVE: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) in patients with pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: Cohort studies have suggested superior short-term outcomes of MIDP vs. ODP. Recent international surveys, however, revealed that surgeons have concerns about the oncological outcomes of MIDP for PDAC. METHODS: This is a pan-European propensity score matched study including patients who underwent MIDP (laparoscopic or robot-assisted) or ODP for PDAC between January 1, 2007 and July 1, 2015. MIDP patients were matched to ODP patients in a 1:1 ratio. Main outcomes were radical (R0) resection, lymph node retrieval, and survival. RESULTS: In total, 1212 patients were included from 34 centers in 11 countries. Of 356 (29%) MIDP patients, 340 could be matched. After matching, the MIDP conversion rate was 19% (n = 62). Median blood loss [200?mL (60-400) vs 300?mL (150-500), P = 0.001] and hospital stay [8 (6-12) vs 9 (7-14) days, P \textless 0.001] were lower after MIDP. Clavien-Dindo grade >=3 complications (18% vs 21%, P = 0.431) and 90-day mortality (2% vs 3%, P \textgreater 0.99) were comparable for MIDP and ODP, respectively. R0 resection rate was higher (67% vs 58%, P = 0.019), whereas Gerota's fascia resection (31% vs 60%, P \textless 0.001) and lymph node retrieval [14 (8-22) vs 22 (14-31), P \textless 0.001] were lower after MIDP. Median overall survival was 28 [95% confidence interval (CI), 22-34] versus 31 (95% CI, 26-36) months (P = 0.929). CONCLUSIONS: Comparable survival was seen after MIDP and ODP for PDAC, but the opposing differences in R0 resection rate, resection of Gerota's fascia, and lymph node retrieval strengthen the need for a randomized trial to confirm the oncological safety of MIDP.
- Published
- 2019
46. Laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein (Kimura's procedure)
- Author
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Igor Khatkov, P. Tyutyunnik, P. Agami, R. Izrailov, and M. Baychorov
- Subjects
S-procedure ,medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,Splenic artery ,Surgery ,medicine.anatomical_structure ,medicine.artery ,medicine ,Spleen preserving ,Vein ,Distal pancreatectomy ,business - Published
- 2021
47. Pancreatic Stump Reinforcement with Falciform Ligament during Laparoscopic Distal Pancreatectomy
- Author
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P. Tyutyunnik, M. Bayorov, P. Agami, Igor Khatkov, A. Andrianov, Victor Tsvirkun, R. Izrailov, D. Salimgereeva, O. Vasnev, and M. Mikhnevich
- Subjects
medicine.medical_specialty ,medicine.anatomical_structure ,Hepatology ,business.industry ,Gastroenterology ,medicine ,Falciform ligament ,Distal pancreatectomy ,business ,Pancreatic stump ,Surgery - Published
- 2021
48. Pancreatic fistula prediction scale for laparoscopic pancreatoduodenectomy
- Author
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A. Andrianov, P. Tyutyunnik, Igor Khatkov, R. Izrailov, O. Vasnev, M. Mikhnevich, P. Agami, M. Baychorov, and Victor Tsvirkun
- Subjects
medicine.medical_specialty ,Hepatology ,Scale (ratio) ,business.industry ,Pancreatic fistula ,Gastroenterology ,medicine ,Radiology ,business ,medicine.disease - Published
- 2021
49. Single center experience of thirty five consecutive total duodenopancreatectomies
- Author
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P. Tytyunnik, R. Izrailov, P. Agami, Igor Khatkov, M. Baychorov, Victor Tsvirkun, M. Mikhnevich, and A. Andrianov
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,General surgery ,Gastroenterology ,medicine ,Single Center ,business - Published
- 2021
50. Laparoscopic pancreatic enucleation of a clear cell renal cell carcinoma metastasis
- Author
-
P. Tyutyunnik, R. Izrailov, Igor Khatkov, M. Baychorov, P. Agami, and A. Andrianov
- Subjects
Pathology ,medicine.medical_specialty ,Clear cell renal cell carcinoma ,Hepatology ,business.industry ,Enucleation ,Gastroenterology ,medicine ,medicine.disease ,business ,Metastasis - Published
- 2021
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