Search

The long-term laboratory aspects of the effects of COVID-19 on liver function are still not well understood. Therefore, this study aimed to evaluate the hepatic clinical-laboratory profile of patients with up to 20 months of long-term COVID-19. A total of 243 patients of both sexes aged 18 years or older hospitalised in the acute phase of COVID-19 were included in this study. Liver function analysis was performed. Changes were identified in the mean levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), and ferritin. Inflammatory markers such as ferritin > 300 U/L were observed in the group that presented more changes in liver function markers (ALT, AST, and GGT). Age ≥ 60 years, male sex, AST > 25 U/L, and GGT ≥ 50 or 32 U/L were associated with ALT > 29 U/L. There was a correlation between ALT and AST, LDH, GGT, and ferritin. Our findings suggest that ALT and AST levels may be elevated in patients with long-term COVID, especially in those hospitalised in the acute phase. In addition, ALT > 29 U/L was associated with other markers of liver injury, such as LDH, GGT, and ferritin.

The long-term laboratory aspects of the effects of coronavirus disease 2019 (COVID-19) on liver function are still not well understood. Therefore, this study aimed to evaluate the hepatic clinical laboratory profile of patients with up to 20 months of long-term COVID-19. A total of 243 patients of both sexes aged 18 years or older admitted during the acute phase of COVID-19 were included in this study. Liver function analysis was performed. Changes were identified in the mean levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), and ferritin. A ferritin level of >300 U/L was observed in the group that presented more changes in liver function markers (ALT, AST, and GGT). Age ≥ 60 years, male sex, AST level > 25 U/L, and GGT level ≥ 50 or 32 U/L were associated with an ALT level > 29 U/L. A correlation was found between ALT and AST, LDH, GGT, and ferritin. Our findings suggest that ALT and AST levels may be elevated in patients with long-term COVID-19, especially in those hospitalised during the acute phase. In addition, an ALT level > 29 U/L was associated with changes in the levels of other markers of liver injury, such as LDH, GGT, and ferritin.

O Programa Institucional de Bolsas de Iniciação Científica para o Ensino Médio objetiva despertar a vocação científica e descobrir novos talentos. Este programa vem sendo discutido por autores sobre diferentes pontos de vista, e este estudo transversal busca analisar quali-quantitativamente o impacto do programa, sobre a escolha profissional dos participantes, relacionando a participação no mesmo e a escolha pela formação na área de Ciências Biológicas e da Saúde, identificando o nível e as características atuais de formação desses ex-alunos e a relação da experiência com o ensino superior, desenvolvido no laboratório de Morfofisiologia aplicado à saúde da Universidade do Estado do Pará (UEPA) no ano de 2011. Foi realizada uma pesquisa de campo exploratória, em seguida foram entrevistados 15 ex-alunos através de um questionário do Formulário Google, com perguntas abertas e fechadas. A análise da estatística descritiva obtida a partir dos dados organizados no Excel revelou que a maioria dos indivíduos possuía baixa renda, alcançaram o ensino superior em instituições de ensino públicas e seguiram carreira na área de Ciências Biológicas e da Saúde. Em relação à análise qualitativa, a maioria dos participantes alega a relevante importância do programa para suas escolhas profissionais e para o crescimento pessoal. Nesse sentido, o trabalho confirma o mérito de Programas como o PIBIC-EM. e reforça a necessidade de haver mais investimentos para a continuidade desse importante Programa.