6 results on '"Ignacio Tobía González"'
Search Results
2. Pyelocaliceal Distribution of Kidney Stones Used as an Outcome Predictor in Percutaneous Nephrolithotomy After Being Evaluated with Preoperative and Postoperative CT Scan
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Mariano Sebastian González, Ignacio Tobía González, Francisco Pedro Juan Daels, and Federico Tirapegui
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Adult ,Male ,Reoperation ,medicine.medical_specialty ,Multivariate analysis ,Urology ,medicine.medical_treatment ,Logistic regression ,Severity of Illness Index ,Kidney Calculi ,Young Adult ,Predictive Value of Tests ,Odds Ratio ,medicine ,Humans ,Multislice ,Postoperative Period ,Percutaneous nephrolithotomy ,Aged ,Nephrostomy, Percutaneous ,Aged, 80 and over ,business.industry ,Univariate ,Middle Aged ,Prognosis ,medicine.disease ,Surgery ,Treatment Outcome ,ROC Curve ,Predictive value of tests ,Multivariate Analysis ,Preoperative Period ,Nephrostomy ,Female ,Kidney stones ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
To identify kidney stone characteristics that will determine either success or failure of a percutaneous nephrolithotomy (PCNL) and design a classification system to predict results according to these characteristics.One hundred thirty-eight patients were assessed with multislice abdominal and pelvic CT before and after PCNL. With regard to pyelocaliceal stone distribution, we classified our patients in two groups that we called "no extra stone in middle calix" (NESMC) and "extra stone in middle calix" (ESMC), according to the difficulty in reaching the stones. We did a univariate and a multivariate analysis, as well as a receiving operating curve (ROC) of the proposed classification, based on the foreseen probabilities, to determine the diagnostic yield.Global residual lithiasis (RL) was 26.08%. The proportion of patients with RL according to classification was NESMC 11.5% and ESMC 59.5%. In the univariate logistic regression analysis of the distribution, number, total volumetry, side, type, radio-opacity of stones, and the presence or not of preoperatory urinary tract infection, the variables related to RL were the distribution (11.3; 95% confidence interval [95% CI] 4.7, 27.4), volumetry (odds ratio [OR] 1.01; 95% CI 1.004, 1.014), and the presence of staghorn stones (OR 6.64; 95% CI 2.463, 17.905). In the multivariate analysis, distribution was statistically significant (OR 8.687; 95% CI 2.69, 28.06), whereas total volumetry and the presence of staghorn stones were not (OR 1; 95% CI 1.000, 1.000 and OR 2.7; 95% CI 0.35, 20.57, respectively). The ROC showed an area under the curve of 0.77.In our experience, the distribution of kidney stones is the most important predictor of RL after PCNL. The results also suggest that the presence of stones in the middle calix has a direct impact on the stone-free rate. We put forward a simple and reproducible classification, easy to apply, and useful to estimate the chances of success of the procedure using preoperatory CT scans.
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- 2015
3. Reference penile size measurement and correlation with other anthropometric dimensions: a prospective study in 800 men
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Martina Solé, Ignacio Tobia González, Martín Compagnucci, Guadalupe Colucci, Marcos Dalvit, Bernardo Chiconi, Omar A Layús, Guillermo Gueglio, and Gastón Rey-Valzacchi
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anthropometric measurements ,micropenis ,penile ,percentile ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Virility and sexual pleasure have long been associated with penile size and this, in turn, has typically been linked to some anthropometric measurements, such as foot size or height, leading to various misconceptions from both men and women. Our intention is to estimate penile size parameters in Argentina and evaluate the correlation between penile size and certain anthropometric measurements. This is a cross-sectional, descriptive, multicenter, and observational study. Male patients who underwent a urological procedure were included in four hospitals located in different regions of the country. Different anthropometric measurements were obtained: height, weight, penile circumference, flaccid and stretched length, and foot length. A total of 800 patients were evaluated. Mean left foot was 26.4 cm. Mean flaccid penile length was 11.4 (95% confidence interval [CI]: 8–14) cm, and mean penile circumference was 10.1 (95% CI: 8–12) cm. Finally, mean stretched penis was 15.2 (95% CI: 11–18.5) cm. We can confirm that estimates of the average penile measurements in Argentina are flaccid penis length of 11.4 cm, penile circumference of 10.1 cm, and stretching the penis to the maximum in flaccidity of 15.2 cm. Correlations between flaccid penis length, stretched out, penile circumference, height, weight, and length of the left foot were evaluated, finding low or no correlation between those mentioned, except for flaccid and stretched length.
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- 2022
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4. High-sensitivity C-reactive protein as a predictor of locally advanced renal cell carcinoma
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Patricio, García-Marchiñena, Nicolas, Billordo-Perés, Ignacio, Tobía-González, Alberto, Jurado, Oscar, Damia, and Guillermo, Gueglio
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Adult ,Aged, 80 and over ,Male ,Smoking ,Middle Aged ,Kidney Neoplasms ,Young Adult ,C-Reactive Protein ,Cross-Sectional Studies ,Logistic Models ,Biomarkers, Tumor ,Disease Progression ,Humans ,Female ,Tomography, X-Ray Computed ,Carcinoma, Renal Cell ,Aged ,Neoplasm Staging ,Retrospective Studies - Abstract
To determine if elevated levels of high-sensitivity C-reactive protein (CRP) in plasma are associated with locally advanced renal cell carcinoma (LARCC) after surgery.Retrospective cross-sectional study conducted from May 2009 to January 2011. Altogether, 192 patients with non-disseminated disease and with preoperative quantitative determination of the CRP were evaluated. We evaluated the relation between age, gender, history of smoking, symptoms and CRP higher than 10 mg/L, with LARCC. The chi-square and Fisher's tests were used to compare categorical variables. For the multivariate analysis, we used logistic regression methods.The median age was 62 years (r=23-85), 72.4% were males. The median CRP was 2.40 mg/L (r=0.1-173). Of all the patients, 43.2% had a history of smoking and 81.8% were asymptomatic. As for the tumors, 77.1%were clear cell carcinoma, 14.6% chromophobe, 4.7% papillary, 2.6% oncocytomas, and 1% other varieties of renal cell carcinoma. As for the TNM classification, 45.8% corresponded to stage pT1a, 27.6% pT1b, 13% pT2, and 13.5% pT3, pT4 was not found. In the multivariate analysis, the presence of symptoms (p=0.002, OR=3.1) and the presence of CRP higher than 10 mg/L (p=0.006, OR=4) remained as the only prognostic variables of LARCC.Values of CRP higher than 10 mg/L increase 4 times the possibilities of finding LARCC in the pathological study of the surgical specimen. This variable should be taken into account when deciding what is the best surgical option.
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- 2012
5. Positive surgical margins are predictors of local recurrence in conservative kidney surgery for pT1 tumors
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Ignacio Tobía González, Alberto Jurado, Sebastián Tirapegui, Guillermo Gueglio, and Patricio García Marchiñena
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Urology ,030232 urology & nephrology ,Kidney ,lcsh:RC870-923 ,Nephrectomy ,Risk Assessment ,Disease-Free Survival ,Surgical Procedures, Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,medicine ,Humans ,Clinical significance ,Kidney surgery ,Stage (cooking) ,Survival rate ,Pathological ,Carcinoma, Renal Cell ,Aged ,Neoplasm Staging ,Retrospective Studies ,business.industry ,Proportional hazards model ,Margins of Excision ,Reproducibility of Results ,Retrospective cohort study ,Middle Aged ,Prognosis ,lcsh:Diseases of the genitourinary system. Urology ,Kidney Neoplasms ,Tumor Burden ,Treatment Outcome ,030220 oncology & carcinogenesis ,Female ,Original Article ,Positive Surgical Margin ,Neoplasm Grading ,Neoplasm Recurrence, Local ,business ,Organ Sparing Treatments - Abstract
Objectives: The clinical significance of positive surgical margin (PSM) after a Nephron Sparing Surgery (NSS) is controversial. The aim of this study is to evaluate the association between PSM and the risk of disease recurrence in patients with pT1 kidney tumors who underwent NSS. Materials and Methods: Retrospective cohort study. A total of 314 patients submitted to a NSS due to stage pT1 renal tumor between January 2010 and June 2015 were included. Recurrence-free survival was estimated. The Cox model was used to adjust the tumor size, histological grade, pathological stage, age, surgical margins and type of approach. Results: Overall PSM was 6.3% (n=22). Recurrence was evidenced in 9.1% (n=2) of patients with PSM and 3.5% (n=10) for the group of negative surgical margin (NSM). The estimated local recurrence-free survival rate at 3 years was 96.4% (95% CI 91.9 to 100) for the NSM group and 87.8% (95% CI 71.9 to 100) for PSM group (p=0.02) with no difference in metastasis-free survival. The PSM and pathological high grade (Fuhrman grade III or IV) were independent predictors of local recurrence in the multivariate analysis (HR 12.9, 95%CI 1.8-94, p=0.011 / HR 38.3, 95%CI 3.1-467, p=0.004 respectively). Fuhrman grade proved to be predictor of distant recurrence (HR 8.1, 95%CI 1.6-39.7, p=0.011). Conclusions: The PSM in pT1 renal tumors showed to have higher risk of local recurrence and thus, worse oncological prognosis.
6. Positive surgical margins are predictors of local recurrence in conservative kidney surgery for pT1 tumors
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Patricio Garcia Marchiñena, Sebastián Tirapegui, Ignacio Tobia Gonzalez, Alberto Jurado, and Guillermo Gueglio
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Kidney ,Surgical Procedures, Neoplasms ,Prognosis ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
ABSTRACT Objectives: The clinical significance of positive surgical margin (PSM) after a Nephron Sparing Surgery (NSS) is controversial. The aim of this study is to evaluate the association between PSM and the risk of disease recurrence in patients with pT1 kidney tumors who underwent NSS. Materials and Methods: Retrospective cohort study. A total of 314 patients submitted to a NSS due to stage pT1 renal tumor between January 2010 and June 2015 were included. Recurrence-free survival was estimated. The Cox model was used to adjust the tumor size, histological grade, pathological stage, age, surgical margins and type of approach. Results: Overall PSM was 6.3% (n=22). Recurrence was evidenced in 9.1% (n=2) of patients with PSM and 3.5% (n=10) for the group of negative surgical margin (NSM). The estimated local recurrence-free survival rate at 3 years was 96.4% (95% CI 91.9 to 100) for the NSM group and 87.8% (95% CI 71.9 to 100) for PSM group (p=0.02) with no difference in metastasis-free survival. The PSM and pathological high grade (Fuhrman grade III or IV) were independent predictors of local recurrence in the multivariate analysis (HR 12.9, 95%CI 1.8-94, p=0.011 / HR 38.3, 95%CI 3.1-467, p=0.004 respectively). Fuhrman grade proved to be predictor of distant recurrence (HR 8.1, 95%CI 1.6-39.7, p=0.011). Conclusions: The PSM in pT1 renal tumors showed to have higher risk of local recurrence and thus, worse oncological prognosis.
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