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1. Mollicutes antibiotic resistance profile and presence of genital abnormalities in couples attending an infertility clinic

Author

Brenda Maldonado-Arriaga, Noé Escobar-Escamilla, Juan Carlos Pérez-Razo, Sofia Lizeth Alcaráz-Estrada, Ignacio Flores-Sánchez, Daniel Moreno-García, Rebeca Pérez-Cabeza de Vaca, Paul Mondragón-Terán, Jonathan Shaw, Cecilia Hernandez-Cortez, Graciela Castro-Escarpulli, and Juan Antonio Suárez-Cuenca

Subjects
Medicine (General), R5-920
Abstract

Objective The present study aimed to identify Mollicutes infection in the reproductive system. We also examined the microbiological, biochemical, and antimicrobial profiles of Mollicutes infection, which are potentially associated with clinical reproductive abnormalities causing infertility in couples. Methods Thirty-seven couples who were attending an infertility clinic were enrolled. Detection of genital mycoplasmas was performed in cervicovaginal samples or male urethral swabs. Microbiological culture and biochemical and antimicrobial profiles were characterized using a Mycoplasma kit. The results were associated with reproductive abnormalities, as assessed by medical specialists from the infertility clinic. Results Up to 28.3% of all biological samples (n = 74) showed positive cultures. Bacterial isolates were Ureaplasma urealyticum (71.4%), Mycoplasma hominis (9.5%), or coinfections (19%). Most Mollicutes showed significant resistance to fluoroquinolones, macrolides, and tetracycline; and showed susceptibility to doxycycline, josamycin, and pristinamycin. The presence of resistant strains to any antibiotic was significantly associated with genital abnormalities (χ 2 test, relative risk = 11.38 [95% confidence interval: 5.8–22.9]), particularly in women. The highest statistical association was found for macrolide-resistant strains. Conclusion The microbiological antibiotic resistance profile is epidemiologically associated with abnormalities of the reproductive system in couples attending an infertility clinic.

Published
2020
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2. [Detection of human papillomavirus types 16 and 18 in semen samples from patients in an assisted reproduction program]

Author

Ignacio, Flores-Sánchez, José, Gutiérrez-Salinas, Evangelina, Enriquez-Alvarado, Sergio, Hernández-Rodríguez, Claudia, Ramos-Barragán, Alejandra, Salamanca-Ceciliano, Leticia, Cruz-Tovar, and Sigrit, Suástegui-Domínguez

Subjects
Adult, Male, Human papillomavirus 16, Human papillomavirus 18, Reproductive Techniques, Assisted, Papillomavirus Infections, Awards and Prizes, Oligospermia, Middle Aged, Polymerase Chain Reaction, Spermatozoa, Obstetrics, Leukocyte Count, Young Adult, Sexual Partners, Gynecology, Semen, DNA, Viral, Humans, Mexico
Abstract

The infection with human papillomavirus (HPV) represents a serious health problem in the world. This is because are associated with cervical cancer development in when HPV of high-risk type 16 and 18 are involved. A genital infection by these virus types are normally asymptomatic in the male and an infection to sexual partner is possible.The objective of the present is the detection of HPV-16 and HPV-18 in semen samples from patients included in an assisted reproduction protocol.Semen samples were obtained from 149 patients that are included in an assisted reproduction protocol in our institution. Semen was examined according with WHO criteria and detection of HPV-16 and HPV-18 was realized with real time PCR protocol with commercial kits. Also, conventional histology techniques were used to assess spermatozoo morphology and leukocyte count.149 semen samples were analyzed from patients with an age average 37.27 (22-56 age). The 56.18% present oligozoospermic and take into account all patients, 59.73% was positive for HPV-16 (29.56%), HPV-18 (16.11%) or both (14.09%). The infection with HPV-16 was more frequent in both oligozoospermic and normozoospermic patients. In this latter, a minus abnormal spermatic cells and leukocytes were found in regard to oligozoospermic patients.There is an important percentage off human asymptomatic male subjects that present in your semen a positive result for high risk papillomavirus. This is very important for the sexual partner because this represent a problem for public health that most be in attention.

Published
2011

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