24 results on '"Iglesias Vázquez JA"'
Search Results
2. Incidence, treatment, and factors associated with survival of out-of-hospital cardiac arrest attended by Spanish emergency services: report from the Out-of-Hospital Spanish Cardiac Arrest Registry for 2022.
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Ruiz Azpiazu JI, Fernández Del Valle P, Carmen Escriche M, Royo Embid S, Fernández Barreras C, Azeli Y, Juanes García M, Batres Gómez S, Valenciano Rodríguez J, Luque Hernández MJ, Navalpotro Pascual JMª, Iglesias Vázquez JA, Echarri Sucunza A, García-Ochoa Blanco MªJ, Del Pozo Pérez C, Cortés Ramas JA, Ceniceros Rozalén MªI, López Pérez C, Guerra García CM, Sola Muñoz S, Redondo Revilla F, Mateo-Rodríguez I, Rosell Ortiz F, and Daponte Codina A
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- Humans, United States, Incidence, Pandemics, Registries, Hospitals, Cardiopulmonary Resuscitation, Out-of-Hospital Cardiac Arrest epidemiology, Out-of-Hospital Cardiac Arrest therapy
- Abstract
Summary: Out-of-hospital cardiac arrest is a serious public health problem worldwide. The annual incidence is estimated at around 400 000 cases in Europe and the United States, and survival rates scarcely reach 10%. However, there is considerable variation between countries and even between regions that share a similar health care system within a single country. Information recorded by the Out-of-Hospital Spanish Cardiac Arrest Registry (OHSCAR) provides information on care provided by emergency ambulance services, final health outcomes after cardiac arrest cases (including variations), the possibility of organ donation, and the impact of the COVID-19 pandemic. This paper presents the OHSCAR report for Spanish emergency services for the year 2022.
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- 2024
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3. Out-of-Hospital Cardiac Arrest Following the COVID-19 Pandemic.
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Ruiz Azpiazu JI, Fernández Del Valle P, Echarri Sucunza A, Iglesias Vázquez JA, Del Pozo C, Knox ECL, Azeli Y, Sánchez García FJ, Fernández Barreras C, Escriche MC, Martín Hernández PJ, Juanes García M, Ramos García N, Royo Embid S, Cortés Ramas JA, Mateo-Rodríguez I, Sola Muñoz S, Alcalá-Zamora Marcó E, Fornér Canos AB, Mainar Gómez B, Dacal Pérez P, Camacho Leis C, García Cortés JJ, Hernández Royano JM, Escalada Roig X, Daponte Codina A, and Rosell Ortiz F
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- Female, Humans, Male, Middle Aged, Cohort Studies, Pandemics, SARS-CoV-2, Aged, Aged, 80 and over, COVID-19 epidemiology, Out-of-Hospital Cardiac Arrest epidemiology, Out-of-Hospital Cardiac Arrest therapy
- Abstract
Importance: Out-of-hospital cardiac arrest (OHCA) health care provision may be a good indicator of the recovery of the health care system involved in OHCA care following the COVID-19 pandemic. There is a lack of data regarding outcomes capable of verifying this recovery., Objective: To determine whether return to spontaneous circulation, overall survival, and survival with good neurological outcome increased in patients with OHCA since the COVID-19 pandemic was brought under control in 2022 compared with prepandemic and pandemic levels., Design, Setting, and Participants: This observational cohort study was conducted to examine health care response and survival with good neurological outcome at hospital discharge in patients treated following OHCA. A 3-month period, including the first wave of the pandemic (February 1 to April 30, 2020), was compared with 2 periods before (April 1, 2017, to March 31, 2018) and after (January 1 to December 31, 2022) the pandemic. Data analysis was performed in July 2023. Emergency medical services (EMS) serving a population of more than 28 million inhabitants across 10 Spanish regions participated. Patients with OHCA were included if participating EMS initiated resuscitation or continued resuscitation initiated by a first responder., Exposure: The pandemic was considered to be under control following the official declaration that infection with SARS-CoV-2 was to be considered another acute respiratory infection., Main Outcome and Measures: The main outcomes were return of spontaneous circulation, overall survival, and survival at hospital discharge with good neurological outcome, expressed as unimpaired or minimally impaired cerebral performance., Results: A total of 14 732 patients (mean [SD] age, 64.2 [17.2] years; 10 451 [71.2%] male) were included, with 6372 OHCAs occurring during the prepandemic period, 1409 OHCAs during the pandemic period, and 6951 OHCAs during the postpandemic period. There was a higher incidence of OHCAs with a resuscitation attempt in the postpandemic period compared with the pandemic period (rate ratio, 4.93; 95% CI, 4.66-5.22; P < .001), with lower incidence of futile resuscitation for OHCAs (2.1 per 100 000 person-years vs 1.3 per 100 000 person-years; rate ratio, 0.81; 95% CI, 0.71-0.92; P < .001). Recovery of spontaneous circulation at hospital admission increased from 20.5% in the pandemic period to 30.5% in the postpandemic period (relative risk [RR], 1.08; 95% CI, 1.06-1.10; P < .001). In the same way, overall survival at discharge increased from 7.6% to 11.2% (RR, 1.45; 95% CI, 1.21-1.75; P < .001), with 6.6% of patients being discharged with good neurological status (Cerebral Performance Category Scale categories 1-2) in the pandemic period compared with 9.6% of patients in the postpandemic period (RR, 1.07; 95% CI, 1.04-1.10; P < .001)., Conclusions and Relevance: In this cohort study, survival with good neurological outcome at hospital discharge following OHCA increased significantly after the COVID-19 pandemic.
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- 2024
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4. Effect of the COVID-19 pandemic on advanced life support units' prehospital management of the stroke code in four Spanish regions: an observational study.
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Riera-López N, Aranda-Aguilar F, Gorchs-Molist M, and Iglesias-Vázquez JA
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- Humans, Pandemics, Ambulances, Retrospective Studies, Emergency Medical Services, COVID-19, Stroke therapy, Stroke diagnosis
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Introduction: Stroke is the most common time-dependent pathology that pre-hospital emergency medical services (EMS) are confronted with. Prioritisation of ambulance dispatch, initial actions and early pre-notification have a major impact on mortality and disability. The COVID-19 pandemic has led to disruptions in the operation of EMS due to the implementation of self-protection measures and increased demand for care. It is crucial to evaluate what has happened to draw the necessary conclusions and propose changes to improve the system's strength for the future. The study aims to compare prehospital time and neuroprotective care metrics for acute stroke patients during the first wave of COVID-19 and the same periods in the years before and after., Methods: Analytical, observational, multicentre study conducted in the autonomous communities of Andalusia, Catalonia, Galicia, and Madrid in the pre-COVID-19 (2019), "first wave" of COVID-19 (2020) and post-COVID-19 (2021) periods. Consecutive non-randomized sampling. Descriptive statistical analysis and hypothesis testing to compare the three time periods, with two by two post-hoc comparisons, and multivariate analysis., Results: A total of 1,709 patients were analysed. During 2020 there was a significant increase in attendance time of 1.8 min compared to 2019, which was not recovered in 2021. The time of symptom onset was recorded in 82.8% of cases, and 83.3% of patients were referred to specialized stroke centres. Neuroprotective measures (airway, blood glucose, temperature, and blood pressure) were performed in 43.6% of patients., Conclusion: During the first wave of COVID-19, the on-scene times of pre-hospital emergency teams increased while keeping the same levels of neuroprotection measures as in the previous and subsequent years. It shows the resilience of EMS under challenging circumstances such as those experienced during the pandemic., (© 2023. BioMed Central Ltd., part of Springer Nature.)
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- 2023
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5. A proposal to incorporate two indicators to the Utsein description of population served by emergency medical service.
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Freire-Tellado M, Navarro-Patón R, Mateos-Lorenzo J, and Iglesias-Vázquez JA
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- Humans, Emergency Service, Hospital, Emergency Medical Services
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Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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- 2023
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6. Persistent gender gaps in out-of-hospital cardiac arrest in Spain from 2013 through 2018.
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Mateo-Rodríguez I, Knox EC, Ruiz-Azpiazu JI, Fernández Del Valle P, Daponte-Codina A, Jiménez-Fàbrega X, Navalpotro-Pascual JMª, Iglesias-Vázquez JA, Echarri-Sucunza A, Alonso-Moreno D, Forner-Canos AB, García-Ochoa Blanco MªJ, Del Pozo-Pérez C, Mainar-Gómez B, Batres-Gómez S, Cortés-Ramas JA, Ceniceros-Rozalén MªI, Guirao-Salinas FÁ, Fernández-Martínez B, Mora MÁ, Carriedo-Scher C, Bragado-Blas MªL, Mellado-Vergel FJ, and Rosell-Ortiz F
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- Female, Humans, Male, Prospective Studies, Sex Factors, Spain epidemiology, Cardiopulmonary Resuscitation, Emergency Medical Services, Out-of-Hospital Cardiac Arrest therapy
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Objectives: To examine gender-related differences in the management and survival of out-of-hospital cardiac arrest (OHCA) in Spain during 2 time series., Material and Methods: Analysis of data recorded in the prospective Spanish OHCA registry (OHSCAR in its Spanish acronym) for 2 time series (2013-2014 and 2017-2018). We included all 11 036 consecutive cases in which an emergency team intervened. The dependent variables were arrival at the hospital after return of spontaneous circulation, overall survival to discharge, and overall survival with good neurological outcomes. Sex was the independent variable. We report descriptive statistics, patient group comparisons, and changes over time., Results: Women were significantly older and less likely to experience an OHCA in a public place, receive automatic external defibrillation, have a shockable heart rhythm, and be attended by an ambulance team within 15 minutes. In addition, fewer women underwent percutaneous coronary interventions or received treatment for hypothermia on admission to the hospital. In 2013-2014 and 2017-2018, respectively, the likelihood of survival was lower for women than men on admission (odds ratio [OR], 0.52 vs OR, 0.61; P .001 and P = .009 in the 2 time series) and at discharge (OR, 0.69 vs 0.72 for men; P = .001 in both time series). Survival with good neurological outcomes was also less likely in women (OR, 0.50 vs 0.63; P .001 in both series)., Conclusion: The odds for survival and survival with good neurological outcomes were lower for women in nearly all patient groups in both time series. These findings suggest the need to adopt new approaches to address gender differences in OHCA.
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- 2022
7. Regional variation in the incidence, general characteristics, and outcomes of prehospital cardiac arrest in Spain: the Out-of-Hospital Spanish Cardiac Arrest Registry.
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Ruiz-Azpiazu JI, Daponte-Codina A, Fernández Del Valle P, López-Cabeza N, Jiménez-Fàbrega FX, Iglesias-Vázquez JA, Guirao-Salinas FÁ, González-León MJ, Fernández-Martínez B, Echarri-Sucunza A, Cortés-Ramas JA, Chueca-García M, Ceniceros-Rozalén MI, Carriedo-Scher C, Caballero-García MA, Bravo-Castello J, Alonso-Moreno D, Adsuar-Quesada JM, Pastor-González E, Muñoz-Castellano J, Mellado-Vergel FJ, Martínez Del Valle M, Martín-Sánchez E, and Rosell-Ortiz F
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- Hospitals, Humans, Incidence, Registries, Retrospective Studies, Spain epidemiology, Cardiopulmonary Resuscitation, Emergency Medical Services, Out-of-Hospital Cardiac Arrest epidemiology, Out-of-Hospital Cardiac Arrest therapy
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Objectives: The incidence and outcomes of care for out-of-hospital cardiac arrest (OHCA) vary greatly from country to country. We aimed to study variation in the incidence, characteristics, and outcomes of care for OHCAs given by Spanish prehospital emergency services., Material and Methods: Descriptive retrospective analysis of data from the Out-of-Hospital Spanish Cardiac Arrest Registry (OHSCAR) from October 2013 to October 2014. Attempts by 19 Spanish emergency services to resuscitate patients were studied. All OHCA cases were reviewed to obtain the following data: incidence, patient and event characteristics, prior emergencies, resuscitation attempts, and the main treatments provided in the hospital. If a patient was admitted, we compared the neurologic status on hospital discharge., Results: Statistically significant differences were detected between emergency services (P .0001) in the incidence of attempted resuscitation and all general characteristics except sex. Hospital treatments and outcomes also differed significantly: pulse had been restored on arrival of 30.5% of patients (range 21.3% to 56.1%, P .001), and 31.8% of admitted patients were discharged in cerebral performance categories 1 or 2 (range 17.2% to 58.3%, P .001)., Conclusion: Differences in the incidence of resuscitation attempts, key variables, and survival at discharge from the hospital are present in OHCA cases attended by prehospital emergency services in different regions of Spain.
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- 2021
8. On the organization of and preparation for the response to the COVID-19 pandemic by Spanish out-of-hospital emergency medical services.
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Iglesias-Vázquez JA, Echarri-Sucunza A, Ruiz-Azpiazu JI, Pastrana Blanco JL, Guirao-Salinas FÁ, Escriche-López C, and Jiménez-Fábrega X
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- Cross-Sectional Studies, Health Care Surveys, Humans, Pandemics, Spain epidemiology, COVID-19 epidemiology, COVID-19 prevention & control, Emergency Medical Services organization & administration
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- 2021
9. Influence of the Covid-19 pandemic on out-of-hospital cardiac arrest. A Spanish nationwide prospective cohort study.
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Rosell Ortiz F, Fernández Del Valle P, Knox EC, Jiménez Fábrega X, Navalpotro Pascual JM, Mateo Rodríguez I, Ruiz Azpiazu JI, Iglesias Vázquez JA, Echarri Sucunza A, Alonso Moreno DF, Forner Canos AB, García-Ochoa Blanco MJ, López Cabeza N, Mainar Gómez B, Batres Gómez S, Cortés Ramas JA, Ceniceros Rozalén MI, Guirao Salas FA, Fernández Martínez B, and Daponte Codina A
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- Aftercare, Aged, COVID-19 epidemiology, Female, Humans, Incidence, Male, Middle Aged, Out-of-Hospital Cardiac Arrest epidemiology, Prospective Studies, SARS-CoV-2, Spain epidemiology, COVID-19 complications, Cardiopulmonary Resuscitation methods, Emergency Medical Services, Out-of-Hospital Cardiac Arrest etiology, Pandemics, Registries
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Aims: The influence of the COVID-19 pandemic on attendance to out-of-hospital cardiac arrest (OHCA) has only been described in city or regional settings. The impact of COVID-19 across an entire country with a high infection rate is yet to be explored., Methods: The study uses data from 8629 cases recorded in two time-series (2017/2018 and 2020) of the Spanish national registry. Data from a non-COVID-19 period and the COVID-19 period (February 1st-April 30th 2020) were compared. During the COVID-19 period, data a further analysis comparing non-pandemic and pandemic weeks (defined according to the WHO declaration on March 11th, 2020) was conducted. The chi-squared analysis examined differences in OHCA attendance and other patient and resuscitation characteristics. Multivariate logistic regression examined survival likelihood to hospital admission and discharge. The multilevel analysis examined the differential effects of regional COVID-19 incidence on these same outcomes., Results: During the COVID-19 period, the incidence of resuscitation attempts declined and survival to hospital admission (OR = 1.72; 95%CI = 1.46-2.04; p < 0.001) and discharge (OR = 1.38; 95%CI = 1.07-1.78; p = 0.013) fell compared to the non-COVID period. This pattern was also observed when comparing non-pandemic weeks and pandemic weeks. COVID-19 incidence impinged significantly upon outcomes regardless of regional variation, with low, medium, and high incidence regions equally affected., Conclusions: The pandemic, irrespective of its incidence, seems to have particularly impeded the pre-hospital phase of OHCA care. Present findings call for the need to adapt out-of-hospital care for periods of serious infection risk., Study Registration Number: ISRCTN10437835., (Copyright © 2020 Elsevier B.V. All rights reserved.)
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- 2020
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10. [Efficacy of nurse consultants in a health emergency coordination center].
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Pedreira Pernas M, Duarte Novo S, Bernárdez Otero M, Pérez López G, Sánchez Santos L, and Iglesias Vázquez JA
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- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Emergency Nursing methods, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Outcome and Process Assessment, Health Care, Remote Consultation methods, Retrospective Studies, Spain, Telephone, Triage methods, Young Adult, Emergency Medical Services organization & administration, Emergency Nursing organization & administration, Remote Consultation organization & administration, Triage organization & administration
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Objectives: To describe nurse consultants' work at the Health Emergency Coordination Center of Galicia (CCUSG-061) in terms of their ability to resolve problems and the appropriateness of their decisions., Material and Methods: Retrospective, observational, descriptive study that included all telephone calls attended by nurses between July 2013 and 2014. The results of a consultation were considered successful if a request for help was resolved without mobilization of resources and did not lead to a new call to the emergency service, a hospital admission, or a death in the next 24 hours., Results: The nurses attended 37 553 calls, resolving 92% without mobilizing resources or patients. Ninety-seven percent of the calls resolved did not generate new calls or complications in the next 24 hours., Conclusion: Nurses resolve most patients' emergency care requirements safely without moving patients or mobilizing health resources.
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- 2016
11. QRS distortion in pre-reperfusion electrocardiogram is a bedside predictor of large myocardium at risk and infarct size (a METOCARD-CNIC trial substudy).
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Valle-Caballero MJ, Fernández-Jiménez R, Díaz-Munoz R, Mateos A, Rodríguez-Álvarez M, Iglesias-Vázquez JA, Saborido C, Navarro C, Dominguez ML, Gorjón L, Fontoira JC, Fuster V, García-Rubira JC, and Ibanez B
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- Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Severity of Illness Index, Electrocardiography, Magnetic Resonance Imaging, Cine methods, Myocardial Infarction diagnosis, Myocardium pathology, Point-of-Care Testing
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Background: QRS distortion is an electrocardiographic (ECG) sign of severe ongoing ischemia in the setting of ST-segment elevation acute myocardial infarction (STEMI). We sought to evaluate the association between the degree of QRS distortion and myocardium at risk and final infarct size, measured by cardiac magnetic resonance (CMR)., Methods: A total of 174 patients with a first anterior STEMI reperfused by primary angioplasty were prospectively recruited. Pre-reperfusion ECG was used to divide the study population into three groups according to the absence of QRS distortion (D0) or its presence in a single lead (D1) or in 2 or more contiguous leads (D2+). Myocardium at risk and infarct size were determined by CMR one week after STEMI. Multiple regression analysis was used to study the association of QRS distortion with myocardium at risk and infarct size, with adjustment for relevant clinical and ECG variables., Results: 101 patients (58%) were in group D0, 30 (17%) in group D1, and 43 (25%) in group D2+. Compared with group D0, presence of QRS distortion (groups D2+ and D1) was associated with a significantly adjusted larger extent of myocardium at risk (group D2+: absolute increase 10.4%, 95% CI 6.1-14.8%, p<0.001; group D1: absolute increase 3.3%, 95% CI 1.3-7.9%, p=0.157) and larger infarct size (group D2+: absolute increase 10.1%, 95% CI 5.5-14.7%, p<0.001; group D1: absolute increase 4.9%, 95% CI 0.08-9.8%, p=0.046)., Conclusions: Distortion in the terminal portion of the QRS complex on pre-reperfusion ECG in two or more leads is independently associated with larger myocardium at risk and infarct size in the setting of primary angioplasty-reperfused anterior STEMI. QRS distortion in only one lead is independently associated with larger infarct size in this setting. Our findings suggest that QRS distortion analysis could be included in risk-stratification of patients presenting with anterior STEMI., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
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- 2016
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12. [Factors predicting survival of out-of-hospital cardiac arrest managed with semiautomatic external defibrillators in Galicia].
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Soto-Araujo L, Costa-Parcero M, González-González MD, Sánchez-Santos L, Iglesias-Vázquez JA, and Rodríguez-Núñez A
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Objectives: To determine prognostic factors in out-of-hospital cardiac arrests managed with semiautomatic external defibrillators (SAEDs) by emergency health service responders in Galicia, Spain., Material and Methods: Retrospective descriptive study of out-of-hospital cardiac arrests treated with SAEDs over a period of 5 years. We collected Utstein outcome data from the database and analyzed the following variables: sex, age, date and time of cardiac event, rural vs urban setting, type of location, witnessed or not, bystander resuscitation attempts or not, time first heart rhythm was detected, use of orotracheal intubation or not, time of call for help, and time to arrival of emergency responders., Results: We analyzed 2005 cases (0.14/1000 person-years; 68.2% male, 70.8% in rural locations, 61% at home). Return of spontaneous circulation (ROSC) was achieved in situ in 10.9% (in 29.9% of patients with shockable rhythms and in 3.3% of those in asystole). Intubation was necessary in 15.7%; ROSC was achieved in 24.8% of the intubated patients. ROSC was achieved in significantly more patients when responders arrived soon after the call for help (mean: 12 minutes, 26 seconds) than when arrival was delayed (mean: 16 minutes, 16 seconds when ROSC was not achieved; P<.001). The presence of a shockable rhythm was also significantly more frequent when response time was faster (P<.001). Asystole, on the other hand, reduced the likelihood of survival (P<.005)., Conclusion: Prognostic factors related to survival of SAED-managed out-of-hospital cardiac arrest in Galicia were the presence of a shockable rhythm, shorter response time, continuation of basic life support measures including advanced airway management, bystander life-support maneuvers, an urban location, and night timing of the arrest.
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- 2015
13. [Chronobiology of out-of-hospital cardiac arrest in Galicia with semi-automatic external defibrillators].
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Soto-Araujo L, Costa-Parcero M, López-Campos M, Sánchez-Santos L, Iglesias-Vázquez JA, and Rodríguez-Núñez A
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- Aged, Aged, 80 and over, Emergency Medical Services, Female, Humans, Male, Middle Aged, Out-of-Hospital Cardiac Arrest therapy, Retrospective Studies, Spain epidemiology, Time Factors, Chronobiology Phenomena, Circadian Rhythm, Defibrillators, Out-of-Hospital Cardiac Arrest epidemiology
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Objective: To analyze the chronobiological variations of out-hospital cardiac arrest in which an automated external defibrillator was used in Galicia., Method: Descriptive retrospective study of the cardiac arrest attended by the Emergency Medical Service in which an automated external defibrillator was in use during a period of 5 years (2007-2011). An Utstein style database was used. The sex, age, date and hour of the event, location, cardiac arrest attended, beginning of resuscitation by the professional, first monitored rhythm, emergency team activation time and care, endotracheal intubation, and recovery of spontaneous circulation were studied as independent variables., Results: A total of 2,005 cases (0.14/1,000 population-year) was recorded. Time slot with more frequency of cardiac arrest: between 09-11 hrs (18.4%). Months with more cases: January (10.4%) and December (9.8%). It was significantly more probable that the cardiac arrest occurred in the home between 00-08 hrs, and in the street between 08-16 hrs. Asystole was more frequent in the night period (00-08 hrs), whereas the shockable rhythm was in the evening (16-00 hrs). There is more probability of death after cardiac arrest between 00-08 hrs, with recovery of spontaneous circulation being more probable between 16-00 hrs. The time between the emergency team activation and time care was longer in night schedule., Conclusions: In Galicia, cardiac arrest is more frequent in the winter months and in morning schedule. There is a circadian distribution of the cardiac arrest and the rhythm detected at the time of the first assistance, with asystole being more common in night schedule and the shockable rhythm in the evening. The chronobiology of the cardiac arrest should be taken into account in order to organize the distribution and the schedule of the healthcare resources., (Copyright © 2013 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.)
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- 2015
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14. Response to letter regarding article, "effect of early metoprolol on infarct size in ST-segment-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: the Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) trial".
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Ibanez B, Macaya C, Sánchez-Brunete V, Pizarro G, Fernández-Friera L, Mateos A, Fernández-Ortiz A, García-Ruiz JM, García-Álvarez A, Iñiguez A, Jiménez-Borreguero J, López-Romero P, Fernández-Jiménez R, Goicolea J, Ruiz-Mateos B, Bastante T, Arias M, Iglesias-Vázquez JA, Rodriguez MD, Escalera N, Acebal C, Cabrera JA, Valenciano J, de Prado AP, Fernández-Campos MJ, Casado I, García-Rubira JC, García-Prieto J, Sanz-Rosa D, Cuellas C, Hernández-Antolín R, Albarrán A, Fernández-Vázquez F, de la Torre-Hernández JM, Pocock S, Sanz G, and Fuster V
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- Female, Humans, Male, Adrenergic beta-Antagonists therapeutic use, Cardiotonic Agents therapeutic use, Metoprolol therapeutic use, Myocardial Infarction drug therapy, Percutaneous Coronary Intervention, Premedication
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- 2014
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15. Effect of early metoprolol on infarct size in ST-segment-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: the Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) trial.
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Ibanez B, Macaya C, Sánchez-Brunete V, Pizarro G, Fernández-Friera L, Mateos A, Fernández-Ortiz A, García-Ruiz JM, García-Álvarez A, Iñiguez A, Jiménez-Borreguero J, López-Romero P, Fernández-Jiménez R, Goicolea J, Ruiz-Mateos B, Bastante T, Arias M, Iglesias-Vázquez JA, Rodriguez MD, Escalera N, Acebal C, Cabrera JA, Valenciano J, Pérez de Prado A, Fernández-Campos MJ, Casado I, García-Rubira JC, García-Prieto J, Sanz-Rosa D, Cuellas C, Hernández-Antolín R, Albarrán A, Fernández-Vázquez F, de la Torre-Hernández JM, Pocock S, Sanz G, and Fuster V
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- Adrenergic beta-Antagonists administration & dosage, Biomarkers, Cardiotonic Agents administration & dosage, Combined Modality Therapy, Creatine Kinase, MB Form blood, Female, Fibrinolytic Agents administration & dosage, Fibrinolytic Agents therapeutic use, Heart Failure prevention & control, Humans, Magnetic Resonance Imaging, Male, Metoprolol administration & dosage, Middle Aged, Myocardial Infarction pathology, Myocardial Infarction physiopathology, Myocardial Infarction surgery, Myocardium pathology, Necrosis, Single-Blind Method, Stroke Volume drug effects, Thrombolytic Therapy, Adrenergic beta-Antagonists therapeutic use, Cardiotonic Agents therapeutic use, Metoprolol therapeutic use, Myocardial Infarction drug therapy, Percutaneous Coronary Intervention, Premedication
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Background: The effect of β-blockers on infarct size when used in conjunction with primary percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces infarct size when administered early (intravenously before reperfusion)., Methods and Results: Patients with Killip class II or less anterior ST-segment-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention within 6 hours of symptoms onset were randomized to receive intravenous metoprolol (n=131) or not (control, n=139) before reperfusion. All patients without contraindications received oral metoprolol within 24 hours. The predefined primary end point was infarct size on magnetic resonance imaging performed 5 to 7 days after STEMI. Magnetic resonance imaging was performed in 220 patients (81%). Mean ± SD infarct size by magnetic resonance imaging was smaller after intravenous metoprolol compared with control (25.6 ± 15.3 versus 32.0 ± 22.2 g; adjusted difference, -6.52; 95% confidence interval, -11.39 to -1.78; P=0.012). In patients with pre-percutaneous coronary intervention Thrombolysis in Myocardial Infarction grade 0 to 1 flow, the adjusted treatment difference in infarct size was -8.13 (95% confidence interval, -13.10 to -3.16; P=0.0024). Infarct size estimated by peak and area under the curve creatine kinase release was measured in all study populations and was significantly reduced by intravenous metoprolol. Left ventricular ejection fraction was higher in the intravenous metoprolol group (adjusted difference, 2.67%; 95% confidence interval, 0.09-5.21; P=0.045). The composite of death, malignant ventricular arrhythmia, cardiogenic shock, atrioventricular block, and reinfarction at 24 hours in the intravenous metoprolol and control groups was 7.1% and 12.3%, respectively (P=0.21)., Conclusions: In patients with anterior Killip class II or less ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention, early intravenous metoprolol before reperfusion reduced infarct size and increased left ventricular ejection fraction with no excess of adverse events during the first 24 hours after STEMI., Clinical Trial Registration Url: http://www.clinicaltrials.gov. Unique identifier: NCT01311700. EUDRACT number: 2010-019939-35.
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- 2013
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16. Study design for the "effect of METOprolol in CARDioproteCtioN during an acute myocardial InfarCtion" (METOCARD-CNIC): a randomized, controlled parallel-group, observer-blinded clinical trial of early pre-reperfusion metoprolol administration in ST-segment elevation myocardial infarction.
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Ibanez B, Fuster V, Macaya C, Sánchez-Brunete V, Pizarro G, López-Romero P, Mateos A, Jiménez-Borreguero J, Fernández-Ortiz A, Sanz G, Fernández-Friera L, Corral E, Barreiro MV, Ruiz-Mateos B, Goicolea J, Hernández-Antolín R, Acebal C, García-Rubira JC, Albarrán A, Zamorano JL, Casado I, Valenciano J, Fernández-Vázquez F, de la Torre JM, Pérez de Prado A, Iglesias-Vázquez JA, Martínez-Tenorio P, and Iñiguez A
- Subjects
- Administration, Oral, Anterior Wall Myocardial Infarction pathology, Drug Administration Schedule, Humans, Infusions, Intravenous methods, Magnetic Resonance Imaging, Single-Blind Method, Stroke Volume, Adrenergic beta-1 Receptor Antagonists administration & dosage, Anterior Wall Myocardial Infarction drug therapy, Metoprolol administration & dosage, Myocardial Reperfusion
- Abstract
Background: Infarct size predicts post-infarction mortality. Oral β-blockade within 24 hours of a ST-segment elevation acute myocardial infarction (STEMI) is a class-IA indication, however early intravenous (IV) β-blockers initiation is not encouraged. In recent magnetic resonance imaging (MRI)-based experimental studies, the β(1)-blocker metoprolol has been shown to reduce infarct size only when administered before coronary reperfusion. To date, there is not a single trial comparing the pre- vs. post-reperfusion β-blocker initiation in STEMI., Objective: The METOCARD-CNIC trial is testing whether the early initiation of IV metoprolol before primary percutaneous coronary intervention (pPCI) could reduce infarct size and improve outcomes when compared to oral post-pPCI metoprolol initiation., Design: The METOCARD-CNIC trial is a randomized parallel-group single-blind (to outcome evaluators) clinical effectiveness trial conducted in 5 Counties across Spain that will enroll 220 participants. Eligible are 18- to 80-year-old patients with anterior STEMI revascularized by pPCI ≤6 hours from symptom onset. Exclusion criteria are Killip-class ≥III, atrioventricular block or active treatment with β-blockers/bronchodilators. Primary end point is infarct size evaluated by MRI 5 to 7 days post-STEMI. Prespecified major secondary end points are salvage-index, left ventricular ejection fraction recovery (day 5-7 to 6 months), the composite of (death/malignant ventricular arrhythmias/reinfarction/admission due to heart failure), and myocardial perfusion., Conclusions: The METOCARD-CNIC trial is testing the hypothesis that the early initiation of IV metoprolol pre-reperfusion reduces infarct size in comparison to initiation of oral metoprolol post-reperfusion. Given the implications of infarct size reduction in STEMI, if positive, this trial might evidence that a refined use of an approved inexpensive drug can improve outcomes of patients with STEMI., (Copyright © 2012 Mosby, Inc. All rights reserved.)
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- 2012
- Full Text
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17. [Assessment of primary care paediatricians performance in a paediatric trauma simulation].
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Civantos Fuentes E, Rodríguez Núñez A, Iglesias Vázquez JA, and Sánchez Santos L
- Subjects
- Models, Anatomic, Retrospective Studies, Clinical Competence, Emergency Treatment, Pediatrics education, Pediatrics standards, Primary Health Care, Wounds and Injuries therapy
- Abstract
Introduction: Training by means of advanced simulation can improve the paediatrician's abilities in the management of paediatric trauma patients, as well as decreasing errors and increasing patient safety. The initial management is an essential factor in the outcome of an injured child., Material and Methods: A trauma patient scenario was included in a national simulation training program. The performances of 156 paediatric primary care providers, divided into 39 teams, who participated in the courses carried out from May 2008 until February 2010 were retrospectively analysed. The evaluation of the scenario was based both on the primary survey suggested by the Working Group on Trauma of the SECIP, and in the 8 main targets of a simulation evaluation tool from the Cincinnati Children's Hospital trauma care program., Results: A pulse oximeter was placed, the intravenous/intraosseous access was indicated, the blood pressure was checked, and the oxygen was applied In 100% of the scenarios. An intravenous fluid bolus was indicated in 87% of the scenarios. The Glasgow scale was performed in 5.1%, and the appropriate warming measures in 25.6%. The bilateral cervical immobilisation was incorrect in 35% of the scenarios (89.7%). The primary survey (ABCDE) was checked correctly in only one scenario. With a top score of 16, based on Cincinnati Hospital, the teams mean score was 5.3 ±1.8., Conclusions: Primary care paediatricians have problems applying the primary ABCDE trauma care sequence and the cervical spine precautions in a trauma simulation scenario. Educational programs for paediatricians must improve the practical check points of the initial approach to trauma management., (Copyright © 2011 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.)
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- 2012
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18. [Out-of-hospital cardiorespiratory arrest. What has changed since the 2005 recommendations?].
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Suárez Saavedra S, Rodríguez Núñez A, Iglesias Vázquez JA, and Rey Galán C
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- Adolescent, Child, Child, Preschool, Humans, Infant, Emergency Treatment, Heart Arrest therapy, Practice Guidelines as Topic
- Published
- 2010
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19. [Advanced simulation for primary care paediatricians. Development of an itinerant program and opinions of participants].
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Sánchez Santos L, Rodríguez Núñez A, Iglesias Vázquez JA, Civantos Fuentes E, Couceiro Gianzo J, Rodríguez Suárez J, and Fernández Sanmartín M
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- Curriculum, Education, Medical, Continuing methods, Spain, Computer Simulation, Pediatrics education, Primary Health Care
- Abstract
Introduction and Objectives: Advanced simulation (AS) is a teaching methodology that has shown to be useful for training health staff at hospital level; however, its application in primary care paediatrics is very limited. Our objective was the development of an AS project focused on the learning needs of the primary care paediatricians, as well as to know the participants' opinions as one of the elements to assess its appropriateness., Material and Methods: Phase 1: A multidisciplinary working group was organized and sponsored by the SEPEAP to design and put the course into practice. Phase 2: Itinerant courses were carried out in several cities in Spain. At the end of each course, a survey was carried out that was focused on motivation aspects, pertinence of contents and methodology. Each item was scored on a numerical scale from 0 (very bad) to 10 (very good)., Study Period: May 2008 to May 2009., Results: After analysing the potential learning needs of target population, available time, teaching material available and methodology of simulation and debriefing, a course model was designed and the cases were programmed. Twelve courses were carried out in 12 cities. The total number of participants was 186; of them, 177 (95.2%) answered the survey. Mean+/-SD scores for main items were: organization (9.23+/-0.50), objectives related to prior expectation (9.29+/-0.43), usefulness of course program to work activity (9.42+/-0.43), cases that resemble reality (9.18+/-0.42) and good instructors-participants relationship (9.68+/-0.20)., Conclusions: The AS course for primary care paediatrics, with the proposed format, is feasible and well adapted to the needs of the target population. Primary care paediatricians consider this type of teaching and learning activity as a useful tool for their continuing education and for improving their professional abilities., (Copyright (c) 2009 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.)
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- 2010
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20. Cost-efficiency assessment of Advanced Life Support (ALS) courses based on the comparison of advanced simulators with conventional manikins.
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Iglesias-Vázquez JA, Rodríguez-Núñez A, Penas-Penas M, Sánchez-Santos L, Cegarra-García M, and Barreiro-Díaz MV
- Abstract
Background: Simulation is an essential tool in modern medical education. The object of this study was to assess, in cost-effective measures, the introduction of new generation simulators in an adult life support (ALS) education program., Methods: Two hundred fifty primary care physicians and nurses were admitted to ten ALS courses (25 students per course). Students were distributed at random in two groups (125 each). Group A candidates were trained and tested with standard ALS manikins and Group B ones with new generation emergency and life support integrated simulator systems., Results: In group A, 98 (78%) candidates passed the course, compared with 110 (88%) in group B (p < 0.01). The total cost of conventional courses was euro 7689 per course and the cost of the advanced simulator courses was euro 29034 per course (p < 0.001). Cost per passed student was euro 392 in group A and euro 1320 in group B (p < 0.001)., Conclusion: Although ALS advanced simulator systems may slightly increase the rate of students who pass the course, the cost-effectiveness of ALS courses with standard manikins is clearly superior.
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- 2007
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21. Paediatric out-of-hospital resuscitation in an area with scattered population (Galicia-Spain).
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Blanco-Ons Fernández P, Sánchez-Santos L, Rodríguez-Núñez A, Iglesias-Vázquez JA, Cegarra-García M, and Barreiro-Díaz MV
- Abstract
Background: Cardiorespiratory arrest (CRA) is a rare event in childhood. Our objective was to determine the characteristics of paediatric CRA and the immediate results of cardiopulmonary resuscitation (CPR) in Galicia, a community with a very scattered population., Methods: All children (aged from newborn to 16 years old) who suffered an out-of-hospital CRA in Galicia and were assisted by the Public Foundation Medical Emergencies of Galicia-061 staff, from June 2002 to February 2005, were included in the study. Data were prospectively recorded following the Utstein's style guidelines., Results: Thirty-one cases were analyzed (3.4 CRA annual cases per 100,000 paediatric population). The arrest was respiratory in 16.1% and cardiac in 83.9% of cases. CRA occurred at home in 58.1% of instances. Time CRA to initiation of CPR was shorter than 10 minutes in 32.2% and longer than 20 minutes in 29.0% of cases. 22.6% of children received bystander CPR. The first recorded rhythm was asystole in 67.7% of cases. Bag-mask ventilation was used in 67.7% and in 83.8% oro-tracheal intubation was done. A peripheral venous access was achieved in 67.7% and intraosseous access was used in 16.1% of patients. 93.5% of children were treated with adrenaline. After initial CPR, sustained restoration of spontaneous circulation was achieved in 38.7% of cases. Six children (19.4%) survived until hospital discharge. Four of 5 children with respiratory arrest survived, whereas only 2 of 26 children with cardiac arrest survived until hospital discharge., Conclusion: Despite the handicap of a highly disseminated population, paediatric CRA characteristics and CPR results in Galicia are comparable to references from other communities. Programs to increase bystander CPR, equip laypeople with basic CPR skills and to update life support knowledge of health staff are needed to improve outcomes.
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- 2007
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22. [Automated external defibrillation in children].
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Rodríguez Núñez A and Iglesias Vázquez JA
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- Child, Child Health Services standards, Heart Arrest etiology, Heart Arrest prevention & control, Humans, Practice Guidelines as Topic, Spain, Ventricular Fibrillation complications, Defibrillators, Electric Countershock instrumentation, Ventricular Fibrillation therapy
- Abstract
Ventricular fibrillation is an infrequent arrhythmia in cardiac arrest occurring in the out-of-hospital setting in infants and small children. However, outcome is good provided early defibrillation is performed; consequently, this procedure is one of the main links in the chain of survival in children with a shockable rhythm. Automated external defibrillators are small devices that can analyze heart rhythm and deliver a dose of electric energy when considered timely by the operator. Automated external defibrillators are easy to use and can be operated, if necessary, by anyone. Therefore, all pediatricians should be aware of how these devices work and be able to use them safely and effectively, following the current defibrillation protocol.
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- 2006
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23. [Semiautomatic defibrillation in children].
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Rodríguez Núñez A and Iglesias Vázquez JA
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- Adolescent, Child, Child, Preschool, Humans, Infant, Defibrillators standards, Heart Arrest therapy, Ventricular Fibrillation therapy
- Abstract
The main survival factor in cardiac arrest secondary to ventricular fibrillation (VF) is the interval between collapse and defibrillation; consequently, this treatment constitutes one of the most important links in the survival chain in adults. Although VF is a rare cause of out-of-hospital cardiac arrest in children, its detection and treatment is essential because in the pediatric cardiac arrest scenario, VF is the dysrhythmia with the best prognosis. Automated external defibrillators (AED) are simple devices that allow cardiac rhythm to be analyzed; they can also determine whether it is shockable or not with high sensitivity and specificity in adults and children. Currently available evidence has prompted the recommendation of AED use in children older than 1 year without signs of circulation, mainly in the pre-hospital setting and ideally with a dose-limiting device.
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- 2004
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24. Results of the introduction of an automated external defibrillation programme for non-medical personnel in Galicia.
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Lobatón CR, Varela-Portas Mariño J, Iglesias Vázquez JA, and Rodríguez MD
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- Adult, Aged, Aged, 80 and over, Emergency Medical Services, Heart Arrest etiology, Heart Arrest mortality, Humans, Middle Aged, Spain, Ventricular Fibrillation complications, Ventricular Fibrillation mortality, Ventricular Fibrillation therapy, Electric Countershock statistics & numerical data, Heart Arrest therapy
- Abstract
Objectives: To describe the plan and development of a programme for the introduction of automated external defibrillation for non medical personnel and to report the results of the first 10 months of activity in a community which is predominently rural, such as Galicia., Methods: The plan for introduction of the project included aspects of logistics, training and control. We studied cardiac arrests, that were treated in basic life support ambulances (BLS-A) equipped with automated external defibrillators (AEDs), from 1st March to 31st December 2001., Results: Our community benefits from pioneering legislation in Spain. During the 10 months of study, 28 AEDs were in service, mostly in urban areas. In all cases, a thorough control of the quality of the service in which AEDs was used was carried out. 12% of the patients, who were victims of sudden cardiac death (SCD) and were found in ventricular fibrillation (VF), survived and were discharged from hospital. However, the percentage of patients found in VF is only around 26%. This is due to long assistance intervals (from the call to the arrival on site), and an important delay from the moment when circulatory collapse takes place until the emergency service 061 is called, more than 5 min in half the cases., Conclusions: The programme followed for the introduction of AEDs in Galicia was adapted to the socio-demographic characteristics of the population. The prehospital emergency assistance model was developed, executed and controlled by the Public Emergency Health Foundation of Galicia 061 (PEHF-061). The overall results of our first 10 months experience with the automated external defibrillation programme were as to be expected. In general, they are comparable to other published reports; however, ways of shortening the times from the point of collapse to defibrillation must be found, mainly by training the population and through the extension of automated external defibrillation provision to other first responders.
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- 2003
- Full Text
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